locus-tag class description BF32_1 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF32_1000 ENOG4105C6Z Gluconate BF32_1001 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF32_1004 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF32_1008 ENOG4105C44 Serine transporter BF32_101 ENOG4105C1J atp-dependent rna helicase BF32_1014 ENOG4108TZY GntR Family Transcriptional Regulator BF32_1015 ENOG4105D9R oxidoreductase BF32_1022 ENOG4105JAB phenazine biosynthesis protein, phzf family BF32_1024 ENOG4105CHR reductase BF32_1026 ENOG4105KNA -acetyltransferase BF32_1029 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF32_103 ENOG4108RZE Tetr family transcriptional regulator BF32_1030 ENOG4105KVH Transcriptional regulator BF32_1034 ENOG4108ZJ4 polysaccharide deacetylase BF32_1042 ENOG4105KAF membrAne BF32_1051 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF32_1055 ENOG4107YXZ hydrolase, family 25 BF32_1062 ENOG4105H3G oxidoreductase BF32_1071 ENOG4105K7K Transcriptional regulator BF32_1072 ENOG4105CIS alcohol dehydrogenase BF32_1078 ENOG4105CHR reductase BF32_1079 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BF32_1080 ENOG4108TN2 lmbE family BF32_1082 ENOG4107R3E Citrate transporter BF32_1085 ENOG4108MES Periplasmic binding protein BF32_1086 ENOG4105EHG Permease protein BF32_1087 ENOG4105DQ5 transport system permease protein BF32_1088 ENOG4105NX3 Membrane BF32_1089 ENOG4107ZY0 Phenazine biosynthesis-like protein BF32_1093 ENOG4107V2S Transcriptional regulator BF32_1097 ENOG4105C98 muts2 protein BF32_1100 ENOG4105E5K Alpha-amylase BF32_1101 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF32_1102 ENOG4105DPN Oligoendopeptidase f BF32_1103 ENOG4108A04 Beta-lactamase BF32_1109 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF32_1114 ENOG41082BM Transcriptional regulator, arsr family BF32_1115 ENOG4105CIS alcohol dehydrogenase BF32_1123 ENOG4105C09 Bile acid BF32_1124 ENOG4105CQB FAD linked oxidase domain protein BF32_1129 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF32_1131 ENOG4105K64 Glycosyl transferase, family 2 BF32_1132 ENOG4105E39 Enoyl-CoA hydratase BF32_1134 ENOG4105KT7 mgtC SapB transporter BF32_1136 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF32_1137 ENOG41073R8 VanW family BF32_1139 ENOG4108R1P BF32_1142 ENOG4105VEQ Cold shock protein BF32_115 ENOG4107WNA Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF32_1151 ENOG410904N short-chain dehydrogenase reductase BF32_1153 ENOG4106IQC argininosuccinate lyase BF32_1156 ENOG4108IA2 Sodium pantothenate symporter BF32_1158 ENOG4105C26 Dehydrogenase BF32_1159 ENOG4105CHR reductase BF32_1161 ENOG4105EWU Squalene--hopene cyclase BF32_1163 ENOG4105FR1 rard protein BF32_1164 ENOG410696E Membrane BF32_1167 ENOG4105D1F ATP-binding protein BF32_1169 ENOG4108ZAF Molybdopterin BF32_1170 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF32_1171 ENOG4105D06 uba thif-type nad fad binding protein BF32_1172 ENOG4105TMB Formate nitrite transporter BF32_1174 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF32_1175 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF32_1177 ENOG4108JB9 formate dehydrogenase BF32_1179 ENOG4105E1K spore germination protein BF32_1193 ENOG4107QJT sodium dicarboxylate symporter BF32_1194 ENOG4108KGH TRANSCRIPTIONal BF32_1196 ENOG4105EMN RNA polymerase sigma factor BF32_12 ENOG4105BZG amino acid carrier protein BF32_120 ENOG41088CC tellurite resistance protein tehB BF32_1200 ENOG4105CIG ABC transporter BF32_1202 ENOG4105D9R oxidoreductase BF32_1205 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF32_1206 ENOG4105K4P CoA-binding domain protein BF32_1207 ENOG4105C0H protease BF32_1208 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_1210 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF32_1211 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF32_1212 ENOG4105W8X HesB YadR YfhF-family protein BF32_1218 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF32_1219 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF32_122 ENOG4107RA9 decarboxylase BF32_1221 ENOG4108JJA ABC, transporter BF32_1222 ENOG4108I0Z Aconitate hydratase BF32_1228 ENOG4105E5W Transporter BF32_123 ENOG4105VTR Integrase BF32_1230 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF32_1234 ENOG4107F3J Amp-dependent synthetase and ligase BF32_1235 ENOG4107ZYJ bioY protein BF32_1236 ENOG4105CEY Amp-dependent synthetase and ligase BF32_1246 ENOG4107AYK membrAne BF32_1248 ENOG4105BZU Histidine kinase BF32_1249 ENOG4105FBA Phospholipase Carboxylesterase BF32_1250 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF32_1251 ENOG4105CK7 Sodium proline symporter BF32_1252 ENOG4105CBC glutamate synthase BF32_1253 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF32_1254 ENOG4108VJ1 Transcriptional regulator (CarD family BF32_1255 ENOG4108903 Formimidoylglutamase BF32_1260 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF32_1269 ENOG4107QIV Cytochrome c biogenesis protein BF32_1271 ENOG4105CH2 amidohydrolase BF32_1273 ENOG4105CJ1 ABC, transporter BF32_1275 ENOG4107RSM transcriptional regulator BF32_1277 ENOG41067MG lrgb family BF32_1282 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF32_1285 ENOG4105BZ1 (ABC) transporter BF32_1286 ENOG4105BZ1 (ABC) transporter BF32_1294 ENOG4105CGH 5'-nucleotidase BF32_1296 ENOG4108SVB resolvase BF32_1300 ENOG4105K7K Transcriptional regulator BF32_1301 ENOG4105C5F glutamine synthetase BF32_1302 ENOG4105KV4 Transcriptional regulator BF32_1303 ENOG4105CXI aluminum resistance protein BF32_1304 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF32_1305 ENOG4105EN6 Membrane BF32_1307 ENOG4106F1P AAA ATPase, central domain protein BF32_1313 ENOG41069ER domain protein BF32_1314 ENOG4105DM4 PTS System BF32_1315 ENOG4105DE4 1-phosphofructokinase BF32_1316 ENOG4105E98 transcriptional regulator DeoR family BF32_1317 ENOG4107QW4 alcohol dehydrogenase BF32_1318 ENOG4108SJC Membrane BF32_1321 ENOG4105C85 amino acid BF32_1325 ENOG4105TMB Formate nitrite transporter BF32_1326 ENOG4105K70 DNA-binding protein BF32_1327 ENOG4105C59 p-type ATPase BF32_1328 ENOG410681U heavy metal transport detoxification protein BF32_1329 ENOG4105VPX protein, conserved in bacteria BF32_1332 ENOG4105NIV Esterase BF32_1333 ENOG4105E0A ABC, transporter BF32_1337 ENOG4105CGK Exodeoxyribonuclease III BF32_1339 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF32_1340 ENOG4105D03 DNA-3-methyladenine glycosylase II BF32_1346 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF32_1347 ENOG4105BZU Histidine kinase BF32_1361 ENOG4105F0V Cell wall hydrolase BF32_1363 ENOG4105E0M Sulfatase BF32_1364 ENOG410890F Dynamin family BF32_1366 ENOG4107QHE Choloylglycine hydrolase BF32_137 ENOG4107RA9 decarboxylase BF32_1372 ENOG4105DQU oxidoreductase, subunit beta BF32_1373 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF32_1374 ENOG4108IGT Dipeptidase BF32_1375 ENOG4105MCT stage V sporulation protein S BF32_1376 ENOG4105D48 metallophosphoesterase BF32_1380 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF32_1383 ENOG4105XZV Protein of unknown function (DUF3243) BF32_1384 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF32_1388 ENOG4105UIB (ABC) transporter BF32_1389 ENOG4108JQ9 ABC transporter BF32_139 ENOG41090HR transcriptional regulator BF32_1390 ENOG4105DIH basic membrane BF32_1391 ENOG4105FDP GntR family transcriptional regulator BF32_1392 ENOG4107QZI cell division protein FtsK BF32_1394 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF32_1396 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF32_1398 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF32_1399 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF32_1400 ENOG4105E35 Dipicolinate synthase subunit A BF32_1402 ENOG4105C1V Peptidase, M16 BF32_1406 ENOG4105DTN riboflavin biosynthesis protein ribF BF32_1409 ENOG4105W7A Protein of unknown function (DUF503) BF32_1411 ENOG4105VHM ribosomal protein BF32_1412 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF32_1413 ENOG4105CHV Transcription elongation factor NusA BF32_1415 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF32_1416 ENOG4105EKQ RNA-directed DNA polymerase BF32_1418 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF32_1420 ENOG4105DZP Membrane-associated zinc metalloprotease BF32_1421 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF32_1422 ENOG4105KNE Phosphatidate cytidylyltransferase BF32_1431 ENOG4108HE4 integrase family BF32_1433 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF32_1434 ENOG4105C79 DNA protecting protein DprA BF32_1435 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF32_1438 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF32_1443 ENOG4105VB6 UPF0109 protein BF32_1447 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF32_1448 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF32_1451 ENOG4105CHR reductase BF32_1452 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF32_1455 ENOG4105CB5 ATP-dependent DNA helicase recG BF32_1456 ENOG4105DP4 dak2 domain fusion protein ylov BF32_1457 ENOG4108ZAA Alkaline-shock protein BF32_1459 ENOG4105FJ0 thiamine BF32_146 ENOG4105CIN aminoacyl-histidine dipeptidase BF32_1460 ENOG4105DJV ribulose-phosphate 3-epimerase BF32_1461 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF32_1462 ENOG4105D9P serine threonine protein kinase BF32_1463 ENOG4108ZF3 Phosphatase BF32_1465 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF32_1467 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF32_1468 ENOG4105C25 Primosomal protein n' BF32_1469 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF32_1473 ENOG4105DSJ YicC domain protein BF32_1475 ENOG4105F23 Fibronectin-binding protein BF32_1476 ENOG4105DC7 peptidase M24 BF32_1489 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF32_149 ENOG4105EQK -acetyltransferase BF32_1494 ENOG4105C34 Pseudouridine synthase BF32_1499 ENOG4105DBK s4 domain protein BF32_1500 ENOG41067XK integral membrane protein BF32_1502 ENOG4105DFA alanine racemase domain protein BF32_1503 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF32_1504 ENOG4105WR5 sporulation protein, YlmC YmxH family BF32_1506 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF32_1508 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF32_1509 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF32_1510 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF32_1511 ENOG4105D4A Cell wall formation (By similarity) BF32_1512 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF32_1513 ENOG4105CNI cell division protein FtsW BF32_1516 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF32_1517 ENOG4105CJN penicillin-binding protein BF32_1518 ENOG4105CJN penicillin-binding protein BF32_1519 ENOG41068DC Essential cell division protein (By similarity) BF32_152 ENOG4107RVG penicillin-binding protein BF32_1526 ENOG4105KNH Nucleic acid-binding protein BF32_1528 ENOG41063PX domain protein BF32_1529 ENOG4105D78 K07001 NTE family protein BF32_1531 ENOG4105H20 Sporulation integral membrane protein YlbJ BF32_1532 ENOG4106H78 methyltransferase BF32_1536 ENOG4107TB6 phosphoglycerate mutase BF32_1539 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF32_1549 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF32_155 ENOG4107RF6 penicillin-binding protein BF32_1550 ENOG4105CNI cell division protein FtsW BF32_1553 ENOG4108IAB Phoh family BF32_1557 ENOG4105QA2 BF32_1558 ENOG4105CI3 gtp-binding protein typa BF32_156 ENOG4107RF6 penicillin-binding protein BF32_1560 ENOG4105ECY inositol monophosphatase BF32_1564 ENOG4105CXN decarboxylase BF32_1573 ENOG4105CPP Dehydrogenase, E1 component BF32_1576 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF32_1577 ENOG4108X4Q Hydrolase BF32_1579 ENOG4105CN5 Metallo-Beta-Lactamase BF32_1580 ENOG4107ZYR domain protein BF32_1587 ENOG4108XRC Protein of unknown function (DUF458) BF32_1589 ENOG4107IN1 Protein of unknown function (DUF1797) BF32_159 ENOG4105ETE Transcriptional regulator (LacI family BF32_1592 ENOG4105EPM Diguanylate phosphodiesterase BF32_1593 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF32_1596 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF32_1598 ENOG4105UIN BF32_16 ENOG4105FE9 pseudouridine synthase BF32_160 ENOG4105IE8 Alpha-ketoglutarate permease BF32_1609 ENOG4108HGU Histidine kinase BF32_161 ENOG4105CK5 oxidoreductase BF32_1611 ENOG4105CHM Aminotransferase BF32_1612 ENOG4105FKQ transcriptional regulator BF32_1613 ENOG4105EG2 ABC transporter, permease BF32_1615 ENOG4107FKK extracellular solute-binding protein family 1 BF32_1617 ENOG4105CG3 alpha amylase, catalytic region BF32_1626 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BF32_1627 ENOG4105CHU acetyl-coa acetyltransferase BF32_1633 ENOG4105K7K Transcriptional regulator BF32_1634 ENOG4105DTD Dehydrogenase BF32_1638 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF32_1646 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF32_1647 ENOG4106TD9 Diguanylate cyclase BF32_1651 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF32_1654 ENOG4105CID antiterminator BF32_1656 ENOG4105FDP GntR family transcriptional regulator BF32_1658 ENOG4105CE4 GlcNAc 6-P deacetylase BF32_166 ENOG4105D2N Aldolase BF32_1665 ENOG4107ZE5 PPIases accelerate the folding of proteins BF32_1666 ENOG4105PTM secreted protein BF32_1667 ENOG4105J7I hydrolase BF32_1669 ENOG4105G6R Stage v sporulation protein ae BF32_167 ENOG4105DH8 myo-inositol catabolism BF32_1671 ENOG4105CZ3 stage V sporulation protein ad BF32_1672 ENOG41090VF Stage v sporulation protein ac BF32_1676 ENOG4105C8J )-transporter BF32_1677 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF32_1679 ENOG41082AN stage II sporulation protein BF32_1680 ENOG4105DZ1 carboxypeptidase BF32_1681 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF32_1682 ENOG4105DVE abc transporter atp-binding protein BF32_1688 ENOG4105D7N magnesium and cobalt transport protein CorA BF32_1693 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF32_1695 ENOG4105I3K Ferric uptake regulator, Fur family BF32_1696 ENOG4105MZ9 stage II sporulation protein m BF32_17 ENOG4105C22 threonyL-tRNA synthetase BF32_1700 ENOG4105CPC Aldo Keto reductase BF32_1702 ENOG4105RHY Pfam:UPF0157 BF32_1706 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF32_1708 ENOG4105ETE Transcriptional regulator (LacI family BF32_1709 ENOG4108YM7 Gcn5-related n-acetyltransferase BF32_1713 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF32_1714 ENOG4108R6K riboflavin synthase, subunit alpha BF32_1719 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF32_172 ENOG4105CGH 5'-nucleotidase BF32_1720 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF32_1723 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF32_1725 ENOG4105DFD Na H antiporter BF32_1726 ENOG4105CGH 5'-nucleotidase BF32_1734 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF32_1737 ENOG4108IXY short-chain dehydrogenase reductase BF32_1738 ENOG41069FQ Metallo-beta-lactamase superfamily BF32_1739 ENOG4105II7 pyrroline-5-carboxylate reductase BF32_174 ENOG4107JM4 Tetratricopeptide repeat BF32_1740 ENOG4105EJQ L-serine dehydratase BF32_1744 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF32_1745 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF32_1746 ENOG4105D9U N-acetyltransferase BF32_1748 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF32_1749 ENOG4108QEG Membrane BF32_175 ENOG4105VZ8 Transcriptional regulator BF32_1750 ENOG4105CDA abc transporter atp-binding protein BF32_1751 ENOG4105E5Q amino acid AbC transporter BF32_1752 ENOG4108HW3 (ABC) transporter BF32_1754 ENOG4105G7B Protein of unknown function (DUF2992) BF32_1755 ENOG4105E09 nadh pyrophosphatase BF32_1757 ENOG4105C7S Dehydrogenase BF32_1758 ENOG4105CPP Dehydrogenase, E1 component BF32_1762 ENOG4107RDP Dehydrogenase BF32_1764 ENOG4108JUB Transcriptional regulator BF32_1766 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF32_1769 ENOG4107QQR Sporulation BF32_1770 ENOG4105S1Z Stage IV sporulation protein B BF32_1771 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF32_1773 ENOG4105DX0 Hemolysin A BF32_1775 ENOG4105CTB Polyprenyl synthetase BF32_178 ENOG4108VXD carboxy-peptidase BF32_1780 ENOG4108ZSR alkaline shock protein BF32_1781 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF32_1786 ENOG410644B Stage III sporulation protein af BF32_1788 ENOG4105KQ4 Stage iii sporulation protein ad BF32_1789 ENOG4108CQH stage III sporulation protein AC BF32_1790 ENOG4105KR5 Stage iii sporulation protein BF32_1791 ENOG4105CD2 stage iii sporulation protein aa BF32_1796 ENOG4105DC7 peptidase M24 BF32_1799 ENOG4105CBJ Metal-dependent enzyme BF32_1800 ENOG4107YBY Hydrolase BF32_1804 ENOG4105K7K Transcriptional regulator BF32_1807 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF32_1808 ENOG4105WZW rhodanese family BF32_181 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BF32_1812 ENOG41080TC multidrug resistance protein BF32_1819 ENOG4105CJ1 ABC, transporter BF32_182 ENOG41067SE Tetr family transcriptional regulator BF32_1820 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF32_1826 ENOG4105C0D helicase BF32_183 ENOG4105C5H ABC transporter BF32_185 ENOG4105BZU Histidine kinase BF32_1850 ENOG4105C3R Methionine synthase BF32_1852 ENOG4105C28 cystathionine BF32_1853 ENOG4105C28 cystathionine BF32_1856 ENOG4105C5X domain protein BF32_1858 ENOG4105DKQ ROK family BF32_1860 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF32_1863 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF32_1864 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF32_1865 ENOG4105E2Z phosphate ABC transporter (Permease BF32_1866 ENOG4105C8U phosphate abc transporter BF32_1867 ENOG4105PWN phosphate abc transporter BF32_1868 ENOG4107RF6 penicillin-binding protein BF32_1870 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF32_1875 ENOG4105N80 Ferric uptake regulator, Fur family BF32_1877 ENOG4105FDK ABC transporter BF32_1878 ENOG4108JYZ YitT family BF32_1879 ENOG41069ZM Protein of unknown function (DUF2624) BF32_188 ENOG4105CEP NADH dehydrogenase BF32_1884 ENOG4105EGD dinuclear metal center protein, YbgI family BF32_1887 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF32_1888 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF32_189 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF32_1893 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF32_1894 ENOG4105KG3 cytidine deaminase BF32_1895 ENOG4107YR5 Diacylglycerol kinase BF32_1897 ENOG4105CTJ Metal Dependent Phosphohydrolase BF32_1898 ENOG4105C9A Phoh family BF32_19 ENOG4105C19 ABC transporter BF32_1900 ENOG41068P3 sporulation protein YqfC BF32_1901 ENOG4105KTH gatB Yqey BF32_1903 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF32_1904 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF32_1908 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF32_1910 ENOG4105CSA Coproporphyrinogen iii oxidase BF32_1911 ENOG4105KVH Transcriptional regulator BF32_1916 ENOG4105TQK DNA polymerase iii, delta' subunit BF32_1918 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF32_1919 ENOG4108UK2 deaminase BF32_1920 ENOG4105KQC Competence protein BF32_1922 ENOG4105DXX methyltransferase BF32_1924 ENOG4108WF2 Metal Dependent Phosphohydrolase BF32_1926 ENOG410812S Rna-binding protein BF32_1928 ENOG4105CQW ribosome biogenesis GTPase YqeH BF32_1929 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF32_193 ENOG4105C1G acyl-Coa dehydrogenase BF32_1932 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF32_1939 ENOG4108TVJ Nitroreductase BF32_194 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF32_1942 ENOG4105G6Z alkaline phosphatase BF32_1944 ENOG4108MUZ hydrolase BF32_195 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF32_1950 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF32_1951 ENOG4105MIR Phenylalanine 4-monooxygenase BF32_1953 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF32_196 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF32_1961 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF32_1962 ENOG4108V5C ABC transporter BF32_1964 ENOG4108EKI Dehydrogenase BF32_1965 ENOG4105C28 cystathionine BF32_197 ENOG4105E39 Enoyl-CoA hydratase BF32_1971 ENOG4107XRG penicillin-binding protein BF32_1974 ENOG4105CFP Peptidase U32 BF32_1975 ENOG4105XYU peptidase (U32 family) BF32_1976 ENOG4108VQJ O-methyltransferase BF32_1977 ENOG4105HHA aminodeoxychorismate lyase BF32_198 ENOG4107QX3 carboxylase BF32_1983 ENOG4105C02 permease BF32_1986 ENOG41060CR BF32_1987 ENOG4105C7H Helicase, RecD TraA family BF32_199 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF32_1990 ENOG4105C3J Cysteine desulfurase BF32_1992 ENOG4105D1H recombination factor protein RarA BF32_1993 ENOG4108VCI transcription factor, rsfa family BF32_1994 ENOG4105CUZ uba thif-type nad fad binding protein BF32_1996 ENOG4105CUT histidyl-tRNA synthetase BF32_1999 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF32_2 ENOG4105WQI isochorismatase BF32_2001 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF32_2002 ENOG41076HS cation diffusion facilitator family transporter BF32_2003 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF32_2005 ENOG4105CKP Polysaccharide Biosynthesis Protein BF32_2006 ENOG4108QG2 Membrane BF32_2008 ENOG4105VIE preprotein translocase, subunit YajC BF32_201 ENOG4105WCN acetyltransferase BF32_2011 ENOG41061AI Protein of unknown function (DUF2905) BF32_2014 ENOG4108HUF Transporter BF32_2016 ENOG4108IPJ Membrane BF32_2017 ENOG41082BM Transcriptional regulator, arsr family BF32_202 ENOG4105DBI uridine monophosphokinase BF32_2022 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF32_2023 ENOG4108IYU L-aspartate oxidase BF32_2026 ENOG4108RPX mosc domain containing protein BF32_2027 ENOG4105CQC Prephenate dehydratase BF32_2031 ENOG4105EWM Histidine kinase BF32_2036 ENOG4105X36 (ribosomal) protein BF32_2038 ENOG4105C03 ribonuclease BF32_2041 ENOG4107QMS site-determining protein BF32_2044 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF32_2045 ENOG4105DFF Rod shape-determining protein mreb BF32_2062 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF32_2063 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF32_2065 ENOG41068KH stage VI sporulation protein D BF32_2067 ENOG4105D52 delta-aminolevulinic acid dehydratase BF32_2072 ENOG4105K56 Transcriptional regulator BF32_2076 ENOG4108IUQ atp-dependent protease BF32_208 ENOG4105T9C HD domain BF32_2083 ENOG4108QCI YvbH-like oligomerisation region BF32_2086 ENOG4105M59 Phosphodiesterase, mj0936 family BF32_2087 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF32_2089 ENOG4108XJQ germination protein BF32_2091 ENOG4108PCX Major Facilitator BF32_2093 ENOG4105KBX Transcriptional regulator, TetR family BF32_2096 ENOG4105PFC Transcriptional regulator BF32_2098 ENOG4105DZC cytosine deaminase BF32_2099 ENOG41067S9 phage shock protein C, PspC BF32_21 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF32_210 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF32_2100 ENOG4108JCI Transcriptional regulator BF32_2102 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF32_2103 ENOG4108Z40 Transcriptional regulator BF32_2104 ENOG4105RHA ABC transporter, permease BF32_2105 ENOG4108IUX (ABC) transporter BF32_2106 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF32_2107 ENOG4105ER2 Ompa motb domain protein BF32_2108 ENOG4105E14 MotA TolQ exbB proton channel BF32_2109 ENOG4108VXD carboxy-peptidase BF32_2111 ENOG4105E33 succinate dehydrogenase BF32_2113 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF32_2116 ENOG4105K63 Thioredoxin BF32_2117 ENOG4105C10 Electron transfer flavoprotein BF32_2118 ENOG4105BZJ Electron transfer flavoprotein BF32_2119 ENOG41060WC Enoyl-CoA hydratase BF32_2120 ENOG4107Z3H Transcriptional regulator, TetR family BF32_2121 ENOG4105CEY Amp-dependent synthetase and ligase BF32_2123 ENOG4105J76 Periplasmic binding protein BF32_2124 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF32_2132 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_2135 ENOG4105DR4 Methyltransferase BF32_2138 ENOG4105KFN sortase, SrtB family BF32_2139 ENOG4105E0A ABC, transporter BF32_2142 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF32_2143 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF32_2145 ENOG4105FE9 pseudouridine synthase BF32_2148 ENOG4105DCG PHP domain protein BF32_2156 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF32_2158 ENOG4108RWN rrna methyltransferase BF32_2167 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF32_2168 ENOG4105CW7 secretion protein, HlyD family BF32_2169 ENOG4108JGH Tetr family transcriptional regulator BF32_2170 ENOG4105CN9 Peptidase m42 family protein BF32_2174 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF32_2175 ENOG4105C22 threonyL-tRNA synthetase BF32_2176 ENOG4108TDW sporulation protein YtxC BF32_218 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF32_218 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF32_2180 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF32_2181 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF32_2182 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF32_2184 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF32_2185 ENOG4105C2M dna polymerase I BF32_2186 ENOG4105BZU Histidine kinase BF32_2187 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_2192 ENOG4108HMX isocitrate dehydrogenase (NADP) BF32_2193 ENOG4105BZN citrate synthase BF32_2195 ENOG4108REF Sporulation integral membrane protein ytvi BF32_2196 ENOG4105FS0 cytoplasmic membrane protein BF32_2201 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF32_2202 ENOG4105C6K Malic enzyme BF32_2203 ENOG4105C0B DNA polymerase III (alpha subunit) BF32_2204 ENOG4105VV2 BF32_2206 ENOG4105SFS phosphoesterase RecJ domain protein BF32_2214 ENOG4105DC7 peptidase M24 BF32_2223 ENOG41082W1 Cupin 2, conserved barrel domain protein BF32_2225 ENOG4105VZ8 Transcriptional regulator BF32_2229 ENOG4107YZX Universal stress protein BF32_2238 ENOG4108JYZ YitT family BF32_2241 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BF32_2243 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF32_2244 ENOG4105KBJ sporulation protein ytfj BF32_2247 ENOG4105EFZ amidohydrolase BF32_2249 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF32_2254 ENOG4106KR7 LysR family Transcriptional regulator BF32_2256 ENOG4105U5Y Transcriptional regulator BF32_2258 ENOG4105C28 cystathionine BF32_2266 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF32_2268 ENOG4105EMN RNA polymerase sigma factor BF32_227 ENOG4105CUV Homoserine Kinase BF32_2272 ENOG4105F1V Acetoin utilization protein BF32_2273 ENOG4105W87 Cbs domain BF32_2274 ENOG4105DGU Histone deacetylase BF32_2277 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_2279 ENOG4107SNB ankyrin repeat protein YahD BF32_2280 ENOG4105EP9 oxidoreductase BF32_2286 ENOG4105ETE Transcriptional regulator (LacI family BF32_2290 ENOG4105C88 aminopeptidase BF32_2299 ENOG4108VDD TRNA binding domain protein BF32_2305 ENOG4105C8F Beta-lactamase domain protein BF32_2308 ENOG4108V15 phosphotransferase enzyme family BF32_2309 ENOG4108IUM Glycogen debranching enzyme BF32_2311 ENOG4107QSE Dipeptidase BF32_2312 ENOG4105YW5 deoR family transcriptional regulator BF32_2315 ENOG4105CBX hi0933 family BF32_2322 ENOG4108VJ1 Transcriptional regulator (CarD family BF32_2323 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF32_2327 ENOG4108ZAF Molybdopterin BF32_2328 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF32_2329 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF32_2331 ENOG4105D06 uba thif-type nad fad binding protein BF32_2332 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF32_2336 ENOG41085GJ domain protein BF32_2338 ENOG4105DWV Homoserine O-trans-acetylase BF32_2340 ENOG4108B31 Spore germination protein BF32_2346 ENOG410605W Major Facilitator BF32_2347 ENOG4107S91 Sodium hydrogen exchanger BF32_2348 ENOG4105NCW Trka-c domain protein BF32_2352 ENOG4105C19 ABC transporter BF32_2356 ENOG4105N5T Radical SAM Protein BF32_2358 ENOG4105CIG ABC transporter BF32_2367 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF32_2368 ENOG4108Z0R Transferase BF32_2369 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF32_2370 ENOG4105BZF Glycosyl transferase (Group 1 BF32_2372 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF32_2384 ENOG4107XGZ Hydrolase BF32_2385 ENOG4105E98 transcriptional regulator DeoR family BF32_2387 ENOG4105BZU Histidine kinase BF32_2388 ENOG4105BZU Histidine kinase BF32_2389 ENOG4107S9D Alpha beta hydrolase BF32_239 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BF32_2390 ENOG4107T7U Sulfatase BF32_2393 ENOG4105D2X ABC transporter substrate-binding protein BF32_2395 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF32_2398 ENOG4107XGZ Hydrolase BF32_2406 ENOG4108V2W Carbonate dehydratase BF32_2408 ENOG4105C4M (Ubiquinol oxidase) subunit I BF32_2409 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF32_241 ENOG4105DK7 lysyl-tRNA synthetase BF32_2418 ENOG41087YS Phage shock protein A BF32_2424 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BF32_2432 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BF32_2433 ENOG4105BZU Histidine kinase BF32_2434 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_2439 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF32_2440 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF32_2441 ENOG4105D7V transposase BF32_2445 ENOG4107ZTW SNARE associated Golgi BF32_2450 ENOG4105C19 ABC transporter BF32_2451 ENOG41086D8 Transcriptional regulator BF32_2459 ENOG4105C6Z Gluconate BF32_2460 ENOG4105FDP GntR family transcriptional regulator BF32_2464 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF32_2468 ENOG4105DTQ mandelate racemase muconate lactonizing BF32_2470 ENOG4108IPT Naphthoate synthase BF32_2471 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF32_2473 ENOG4105E4F Isochorismate synthase BF32_2474 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF32_2476 ENOG4105VEQ Cold shock protein BF32_2486 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF32_2487 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF32_2506 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF32_2514 ENOG4105KT7 mgtC SapB transporter BF32_2516 ENOG4107PBV potassium channel BF32_2518 ENOG4105WG9 Conserved Protein BF32_2520 ENOG4105CHM Aminotransferase BF32_2521 ENOG4108ZB6 transcriptional regulator AsnC family BF32_2522 ENOG4105C5I Dehydrogenase BF32_2523 ENOG4108MUZ hydrolase BF32_2525 ENOG4105C87 Aminotransferase class I and II BF32_2528 ENOG4105Y38 Kinase-associated protein B BF32_2530 ENOG4107R3E Citrate transporter BF32_2533 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF32_2534 ENOG4105KA0 thioesterase Superfamily protein BF32_2537 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF32_2541 ENOG41069ER domain protein BF32_2544 ENOG4105CEP NADH dehydrogenase BF32_2550 ENOG4105EWC Purine nucleoside phosphorylase BF32_2552 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF32_2556 ENOG4108JJA ABC, transporter BF32_2557 ENOG4105C4B ABC transporter, permease BF32_2558 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF32_2563 ENOG41083MR nifu domain-containing protein BF32_2566 ENOG4108W5N phosphatidylglycerophosphatase a BF32_2569 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF32_2570 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF32_2571 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF32_2574 ENOG4105CBT Fructose-1,6-bisphosphatase BF32_2577 ENOG4105MMD transcriptional regulator BF32_2578 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF32_2579 ENOG4107TXC Transcriptional regulator BF32_258 ENOG4105ETU transcriptional activator (TenA BF32_2580 ENOG41090T1 Membrane BF32_2585 ENOG4105FAA peptidase M23 BF32_2587 ENOG4105KZD Domain of unknown function (DUF1805) BF32_2588 ENOG4107R8B 5'-nucleotidase BF32_2591 ENOG4105DIW FeS assembly protein SUFB BF32_2592 ENOG4108UNV SUF system FeS assembly protein, NifU family BF32_2593 ENOG4105C9B Cysteine desulfurase BF32_2594 ENOG4105JRK feS assembly protein SufD BF32_2595 ENOG4105C3K feS assembly ATPase SufC BF32_2596 ENOG4105D01 (LipO)protein BF32_2597 ENOG4105D01 (LipO)protein BF32_2598 ENOG4108UMI ABC transporter, permease BF32_26 ENOG4108D32 Methyltransferase BF32_2604 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF32_2613 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF32_2620 ENOG4108W8B Beta-lactamase domain protein BF32_2623 ENOG4108IUW ABC transporter BF32_2628 ENOG4105C1G acyl-Coa dehydrogenase BF32_2629 ENOG4105CHU acetyl-coa acetyltransferase BF32_2632 ENOG4105DZ1 carboxypeptidase BF32_2636 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF32_2640 ENOG4108SUT Major Facilitator Superfamily BF32_2641 ENOG4107R7I amino acid BF32_2644 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF32_2646 ENOG4107AYK membrAne BF32_2654 ENOG4107ZTW SNARE associated Golgi BF32_2656 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF32_2657 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_2658 ENOG4105BZU Histidine kinase BF32_2662 ENOG4105C8Q Methyl-accepting chemotaxis BF32_2663 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF32_2664 ENOG4105VG1 fes assembly suf system protein BF32_2665 ENOG4105D4Y metalloprotease BF32_2669 ENOG4107S91 Sodium hydrogen exchanger BF32_2670 ENOG4105NCW Trka-c domain protein BF32_2672 ENOG4108RMU ferritin dps family protein BF32_2675 ENOG4108URH decarboxylase BF32_2679 ENOG4105D9N nucleoside BF32_2680 ENOG4105D9N nucleoside BF32_2683 ENOG4108RYK Nad-dependent epimerase dehydratase BF32_2686 ENOG4105CV8 reductase BF32_2687 ENOG4105F27 Major Facilitator BF32_2688 ENOG4105KVH Transcriptional regulator BF32_2691 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF32_2692 ENOG4105D4A Cell wall formation (By similarity) BF32_2696 ENOG4105WMR Protein CrcB homolog BF32_2701 ENOG4105C5H ABC transporter BF32_2702 ENOG4108MK9 spermidine N(1)-acetyltransferase BF32_2703 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF32_2706 ENOG4108IPW abc transporter atp-binding protein BF32_2707 ENOG4105CM4 permease protein BF32_2712 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF32_2714 ENOG4105XZU Preprotein translocase, subunit SecG BF32_2715 ENOG41067MG lrgb family BF32_2725 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF32_2729 ENOG41090VF Stage v sporulation protein ac BF32_2730 ENOG4105CZ3 stage V sporulation protein ad BF32_2733 ENOG4105H67 Protein of unknown function (DUF421) BF32_2734 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF32_2735 ENOG4105KRI phosphocarrier protein (HPr BF32_2737 ENOG4105CHW UPF0052 protein BF32_2739 ENOG4108Z4K mutator MutT protein BF32_2741 ENOG4105C3M thioredoxin reductase BF32_2743 ENOG4108S4C acetyltransferase BF32_2747 ENOG41086DT Membrane protein of unknown function BF32_2757 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF32_2758 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BF32_2761 ENOG4107TXC Transcriptional regulator BF32_2766 ENOG4105HMI Membrane BF32_2767 ENOG4105DUM transcriptional regulator, lysR family BF32_2769 ENOG4108WS4 fmn reductase BF32_2770 ENOG4105C5H ABC transporter BF32_2772 ENOG4105BZ1 (ABC) transporter BF32_2774 ENOG4105CN1 protease BF32_2775 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF32_2776 ENOG4105CAK Cell division ATP-binding protein ftsE BF32_2778 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF32_2780 ENOG4105MS2 ribosomal subunit Interface protein BF32_2781 ENOG4105VEQ Cold shock protein BF32_2782 ENOG41081UC Inherit from COG: Competence protein BF32_2785 ENOG4105KVH Transcriptional regulator BF32_2787 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF32_2788 ENOG4108KGH TRANSCRIPTIONal BF32_2789 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF32_2790 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF32_2791 ENOG4105ESV Glycosyl transferase, family 4 BF32_2793 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF32_2797 ENOG4105F8D glycoside hydrolase family 4 BF32_2798 ENOG4105VCP PTS System BF32_2799 ENOG4105CK1 PTS System BF32_2801 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF32_2805 ENOG4105VCP PTS System BF32_2807 ENOG4105VZJ PTS System BF32_2810 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BF32_2814 ENOG4105ECB domain protein BF32_2815 ENOG4107RSM transcriptional regulator BF32_282 ENOG410667J hydrolase BF32_2822 ENOG4105DAA L-lactate BF32_2823 ENOG4105D7V transposase BF32_2825 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF32_2827 ENOG4105E0M Sulfatase BF32_283 ENOG4105BZU Histidine kinase BF32_2832 ENOG4107R8N Glycosyl transferase, family 2 BF32_2834 ENOG4105C94 Transporter BF32_2835 ENOG41069ER domain protein BF32_284 ENOG4107RF6 penicillin-binding protein BF32_2840 ENOG4105KBK Zinc finger, swim domain protein BF32_2841 ENOG4105C0D helicase BF32_2847 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF32_2850 ENOG4107RBB ABC transporter, permease BF32_2851 ENOG4105C19 ABC transporter BF32_2855 ENOG4105CXY transporter BF32_2859 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_2860 ENOG4105DG6 mannose-6-phosphate isomerase BF32_2861 ENOG4105DM4 PTS System BF32_2863 ENOG4105CMR udp-glucose 4-epimerase BF32_2865 ENOG4108KGH TRANSCRIPTIONal BF32_2866 ENOG4105DG6 mannose-6-phosphate isomerase BF32_2867 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BF32_2868 ENOG4105CPK Glycosyl transferase (Group 1 BF32_2869 ENOG4108TJN glycosyl transferase group 1 BF32_2870 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF32_2874 ENOG4105D3Q Sugar transferase BF32_2875 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF32_2876 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BF32_2877 ENOG4107YJ4 chain length determinant protein BF32_2878 ENOG4105HTX biosynthesis protein BF32_2879 ENOG4107YJ4 chain length determinant protein BF32_2882 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF32_2883 ENOG4105FRN stage II sporulation protein BF32_2886 ENOG4105DY9 regulatoR BF32_2890 ENOG4106778 Protein of unknown function (DUF1146) BF32_2891 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF32_2892 ENOG4105C8S subunit m BF32_2893 ENOG4105D65 subunit l BF32_2899 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF32_2901 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF32_2902 ENOG4105BZU Histidine kinase BF32_291 ENOG4108HGU Histidine kinase BF32_2912 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF32_2913 ENOG41062M3 atp synthase BF32_2918 ENOG4108YZG isomerase BF32_2921 ENOG4108VGI doxx family BF32_2922 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF32_2926 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF32_2928 ENOG4108ZXQ stage ii sporulation protein r BF32_2929 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF32_293 ENOG4105RHY Pfam:UPF0157 BF32_2930 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF32_2933 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF32_2934 ENOG4105CBT Fructose-1,6-bisphosphatase BF32_2935 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF32_294 ENOG4105CB2 alcohol dehydrogenase BF32_2942 ENOG4105C1G acyl-Coa dehydrogenase BF32_2943 ENOG4105C1G acyl-Coa dehydrogenase BF32_2944 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF32_2946 ENOG4105DF6 Fe-S oxidoreductase BF32_2949 ENOG4105BZU Histidine kinase BF32_295 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF32_2954 ENOG4105BZU Histidine kinase BF32_2955 ENOG4105KCT ABC transporter BF32_2956 ENOG4108M15 ABC transporter BF32_2957 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF32_2959 ENOG4105IIU Aminopeptidase BF32_296 ENOG4105CJN penicillin-binding protein BF32_2963 ENOG4105EMN RNA polymerase sigma factor BF32_2965 ENOG410684U Domain of unknown function (DUF1934) BF32_2969 ENOG4105CYW agmatinase BF32_297 ENOG4108IG5 Transcriptional regulator BF32_2971 ENOG4105DXB Major Facilitator superfamily BF32_2972 ENOG4107SWG transcriptional regulator MERR family BF32_2973 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF32_2974 ENOG4105BZ4 penicillin-binding protein BF32_2975 ENOG4108XFG YwhD family BF32_2976 ENOG4108Z4T Peptidase M50 BF32_2977 ENOG41069HH 4-oxalocrotonate tautomerase BF32_2978 ENOG4105DCI Phosphohydrolase BF32_2979 ENOG4108MES Periplasmic binding protein BF32_298 ENOG4107GJV short-chain dehydrogenase reductase BF32_2980 ENOG4105E0A ABC, transporter BF32_2981 ENOG4105EHG Permease protein BF32_2982 ENOG4105DQ5 transport system permease protein BF32_2984 ENOG4108VCI transcription factor, rsfa family BF32_2987 ENOG4108IJ2 phosphate acetyltransferase BF32_2990 ENOG4108VKI Cell wall hydrolase BF32_2994 ENOG4107SVH Potassium channel protein BF32_2996 ENOG410667J hydrolase BF32_2997 ENOG4105VCH membrane BF32_2999 ENOG4108TU7 Inherit from COG: (ABC) transporter BF32_3 ENOG4105CEY Amp-dependent synthetase and ligase BF32_300 ENOG4105FQP Beta-lactamase BF32_3000 ENOG4105CJ1 ABC, transporter BF32_3001 ENOG41090WU lipolytic protein G-D-S-L family BF32_3004 ENOG4105D6E homoserine dehydrogenase BF32_3008 ENOG4108Y4K DNA-binding transcriptional activator BF32_3010 ENOG4105WH1 Two component transcriptional regulator luxr family BF32_3011 ENOG4105BZU Histidine kinase BF32_3012 ENOG4105DWF phosphomethylpyrimidine kinase BF32_3013 ENOG4105BZU Histidine kinase BF32_3014 ENOG4105VCD cytoplasmic protein BF32_3015 ENOG4105D22 carbon starvation protein BF32_3016 ENOG4105DY9 regulatoR BF32_3017 ENOG41079KZ Major Facilitator Superfamily BF32_3021 ENOG4105EN6 Membrane BF32_3022 ENOG4106YBV Methyl-accepting chemotaxis BF32_3024 ENOG4108S4H thioesterase Superfamily protein BF32_3026 ENOG4105JEU Glycosyl transferase, family 2 BF32_3027 ENOG4105C5H ABC transporter BF32_3031 ENOG4105CKK Glycosyl transferase, family 2 BF32_3032 ENOG41067SE Tetr family transcriptional regulator BF32_3034 ENOG4105E0X reductase BF32_3035 ENOG4106F5Q Membrane BF32_3038 ENOG4105DY9 regulatoR BF32_3039 ENOG4108HRK Histidine kinase BF32_3040 ENOG4107RGD Major Facilitator superfamily BF32_3043 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF32_3045 ENOG4105IW1 AmiS UreI transporter BF32_3047 ENOG4105CMR udp-glucose 4-epimerase BF32_3048 ENOG4108UT2 hemolysin iii BF32_3050 ENOG4105C1J atp-dependent rna helicase BF32_3053 ENOG4105DPN Oligoendopeptidase f BF32_3057 ENOG4105C0H protease BF32_3058 ENOG4105Q2H domain protein BF32_3061 ENOG4105BZU Histidine kinase BF32_3062 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_3068 ENOG4105CDU Replicative dna helicase BF32_307 ENOG4108V4B ThiJ pfpI BF32_3070 ENOG4105BZR domain protein BF32_3071 ENOG4108XMW Membrane BF32_3073 ENOG4108UUM single-stranded DNA-binding protein BF32_3075 ENOG4105C3G gtp-binding protein BF32_3076 ENOG4105VDK protein, conserved in bacteria BF32_3077 ENOG4105D8X mechanosensitive ion channel BF32_3078 ENOG4108ZDA Sporulation protein YyaC BF32_3079 ENOG4105FA0 parb-like partition protein BF32_3080 ENOG4107QJE Chromosome Partitioning Protein BF32_3086 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF32_3090 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF32_3091 ENOG410848D S4 domain protein YaaA BF32_3094 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF32_3102 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF32_3109 ENOG4105ZMH deoxynucleoside kinase BF32_3111 ENOG4105GTG Isochorismatase BF32_3112 ENOG4108Z6B deaminase BF32_3113 ENOG4105C6E dna polymerase iii BF32_3117 ENOG41067KS pro-sigma K processing BF32_312 ENOG4107Y80 Major Facilitator superfamily BF32_3125 ENOG4105CXN decarboxylase BF32_3127 ENOG4105FA2 dna polymerase iii BF32_3128 ENOG4105MA4 psp1 domain protein BF32_3130 ENOG41060K3 Methyltransferase BF32_3132 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF32_3133 ENOG4105KRN Transcriptional regulator, abrb family BF32_3135 ENOG4105F8V Hydrolase, tatD family BF32_3136 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF32_3138 ENOG4105XFA sporulation peptidase YabG BF32_3139 ENOG4105W42 Veg protein BF32_3142 ENOG4105DFT pur operon repressor BF32_3143 ENOG4105KME endoribonuclease L-psp BF32_3146 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF32_3147 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BF32_3149 ENOG4108JA2 transcriptioN-repair coupling factor BF32_3150 ENOG4108M14 stage v sporulation protein t BF32_3152 ENOG4108IY2 MazG family BF32_3153 ENOG41082I2 s4 domain protein BF32_3154 ENOG4105VYY sporulation protein yabp BF32_3157 ENOG41060GV RNA binding s1 domain protein BF32_316 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF32_3162 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF32_3163 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF32_3166 ENOG4105C6T cysteine synthase BF32_3167 ENOG4105CRQ synthase (Component I) BF32_3168 ENOG4105DDQ anthranilate synthase BF32_3169 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF32_3170 ENOG4105EEI dihydropteroate synthase BF32_3171 ENOG4105KRF dihydroneopterin aldolase BF32_3172 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF32_3174 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF32_3194 ENOG4108Z0C Uvrb UvrC protein BF32_3197 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF32_3199 ENOG4105CTP PilT protein domain protein BF32_3203 ENOG4105D7W serine acetyltransferase BF32_3206 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF32_3207 ENOG4105M0M Tetracycline resistance protein BF32_3208 ENOG4105QIV RNA polymerase BF32_321 ENOG4107Y9U Membrane BF32_3210 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF32_3215 ENOG4107Y49 methyltransferase BF32_3218 ENOG4105XPM ribosomal protein BF32_3239 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF32_3244 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF32_3246 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF32_3248 ENOG41067V7 50S ribosomal protein L36 BF32_3255 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF32_3256 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF32_3261 ENOG4105D1F ATP-binding protein BF32_3264 ENOG4108NMV polysaccharide deacetylase BF32_328 ENOG4105FCD Major Facilitator BF32_3281 ENOG4105C8B TIGR00159 family BF32_3282 ENOG4107U5W ybbr family BF32_3288 ENOG4105CMG Carbohydrate kinase BF32_329 ENOG4105E09 nadh pyrophosphatase BF32_3290 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF32_3291 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BF32_3299 ENOG4108PSK reductase BF32_33 ENOG41081I9 integral membrane protein BF32_330 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF32_3300 ENOG4108UMI ABC transporter, permease BF32_3301 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF32_3302 ENOG4105D01 (LipO)protein BF32_3303 ENOG4105EE1 crotonyl-CoA reductase BF32_3305 ENOG4105IQ5 FAD linked oxidase domain protein BF32_3308 ENOG4105C2C drug resistance transporter, Bcr CflA BF32_331 ENOG4108Z4K mutator MutT protein BF32_3310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF32_3311 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF32_3312 ENOG4105C3U ABC transporter BF32_3313 ENOG4108JQ7 (ABC) transporter BF32_3318 ENOG4105U5Y Transcriptional regulator BF32_3320 ENOG4108J59 Extracellular solute-binding protein, family 5 BF32_3321 ENOG4108J59 Extracellular solute-binding protein, family 5 BF32_3323 ENOG4105II7 pyrroline-5-carboxylate reductase BF32_3324 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF32_3326 ENOG4105E0C molybdate abc transporter BF32_3327 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF32_3328 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF32_3335 ENOG4105F6E Acyl-transferase BF32_3339 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF32_3342 ENOG4108RE7 deoxyribonuclease BF32_3344 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF32_3348 ENOG4105C5H ABC transporter BF32_335 ENOG4107TB6 phosphoglycerate mutase BF32_3351 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BF32_3353 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF32_3354 ENOG4105C3U ABC transporter BF32_3355 ENOG4108JQ7 (ABC) transporter BF32_3356 ENOG410667J hydrolase BF32_3362 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF32_3363 ENOG4105ERH Fumarylacetoacetate hydrolase BF32_3365 ENOG4105CUB amino acid BF32_3366 ENOG4108SC4 )-transporter BF32_3367 ENOG4105CPF Cell wall formation (By similarity) BF32_3368 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF32_337 ENOG4108XI2 Domain of unknown function (DUF1963) BF32_3370 ENOG4107ZXI Rhomboid family BF32_3373 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF32_3374 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF32_3376 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF32_3396 ENOG4105K8N protein family UPF0079, ATPase BF32_3397 ENOG41072GX Peptidase M22 Glycoprotease BF32_3398 ENOG410801F ribosomal-protein-alanine acetyltransferase BF32_3400 ENOG4105C5H ABC transporter BF32_3403 ENOG4108TYN CAAX amino terminal protease family protein BF32_3406 ENOG4107EV6 Inherit from COG: YD repeat protein BF32_3410 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BF32_3418 ENOG4105C7N Xanthine uracil vitamin C permease BF32_342 ENOG4108NRW Phospholipase, patatin family BF32_3420 ENOG4105BZU Histidine kinase BF32_3426 ENOG4107ZXU DSBA oxidoreductase BF32_343 ENOG4105KWG Pfam:DUF1696 BF32_3440 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_3444 ENOG4105SX7 Transporter BF32_3450 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF32_3451 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF32_3452 ENOG4105C83 adenylosuccinate lyase BF32_3454 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF32_3459 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF32_3461 ENOG4105C12 Phosphoribosylglycinamide synthetase BF32_3466 ENOG4105C4R Atp-dependent dna helicase BF32_3472 ENOG4108W2Y isochorismatase BF32_3473 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF32_3474 ENOG4108UMI ABC transporter, permease BF32_3475 ENOG4105D01 (LipO)protein BF32_3481 ENOG410834F Transcriptional regulator BF32_3482 ENOG4107I77 yiaA/B two helix domain BF32_3486 ENOG4105CBD Diacylglycerol kinase BF32_3487 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF32_3488 ENOG4108JPW Aminotransferase BF32_3490 ENOG4105C26 Dehydrogenase BF32_3491 ENOG4105KPY Small multidrug resistance protein BF32_3495 ENOG4105D9N nucleoside BF32_3496 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF32_3498 ENOG4105BZU Histidine kinase BF32_3499 ENOG4108W15 Protein of unknown function (DUF1456) BF32_350 ENOG4105PKS Excinuclease abc c subunit domain protein BF32_3502 ENOG4105DTQ mandelate racemase muconate lactonizing BF32_3503 ENOG4105DFD Na H antiporter BF32_3508 ENOG4105D3R alkyl hydroperoxide reductase BF32_3509 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF32_3511 ENOG4107W7X Aldolase BF32_3512 ENOG4105EHG Permease protein BF32_3513 ENOG4105DQ5 transport system permease protein BF32_3514 ENOG4108V5C ABC transporter BF32_3518 ENOG4106UIA BF32_3519 ENOG4106UIA BF32_3523 ENOG4105BZU Histidine kinase BF32_3527 ENOG410756H nucleotidyltransferase BF32_3528 ENOG4105D2S major facilitator superfamily BF32_3532 ENOG4105EAB amino acid AbC transporter BF32_3534 ENOG4105C8Q Methyl-accepting chemotaxis BF32_3537 ENOG4105DBV ornithine carbamoyltransferase BF32_3539 ENOG4105C5B carbamate kinase BF32_3543 ENOG4105CI1 PTS System BF32_3549 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF32_3552 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF32_3556 ENOG4105C5H ABC transporter BF32_3557 ENOG4105C5H ABC transporter BF32_3562 ENOG41062JF Transcriptional regulator BF32_3566 ENOG4105DEU major facilitator superfamily BF32_357 ENOG4107VFR oxidoreductase BF32_3572 ENOG4108N0M stress protein BF32_3573 ENOG4106FN3 tellurium resistance protein BF32_3574 ENOG4106FN3 tellurium resistance protein BF32_3575 ENOG4107TS3 membrane protein, TerC BF32_3576 ENOG4108TTB tellurium resistance protein BF32_3580 ENOG4105KJF protein tyrosine phosphatase BF32_3582 ENOG4107U9T Pfam:Ribonuclease_BN BF32_3583 ENOG4105C59 p-type ATPase BF32_3584 ENOG4108IPJ Membrane BF32_3588 ENOG4107ZTW SNARE associated Golgi BF32_3591 ENOG410606W general stress protein BF32_3592 ENOG4105UPD Calcium Proton BF32_36 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF32_3600 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF32_3602 ENOG4108JUB Transcriptional regulator BF32_3604 ENOG4108IQI permease BF32_3610 ENOG4105CSV Glutaminase BF32_3612 ENOG4108A04 Beta-lactamase BF32_3615 ENOG4105CKK Glycosyl transferase, family 2 BF32_3616 ENOG4107QQG Dehydrogenase BF32_3617 ENOG4105C3I Nad-dependent epimerase dehydratase BF32_362 ENOG4105PAD Hydrolase BF32_3620 ENOG4105F1A Pyruvate formate-lyase BF32_3624 ENOG4105CI2 imidazolone-5-propionate hydrolase BF32_3625 ENOG4105ECP epimerase BF32_3631 ENOG41067AE Membrane-bound metal-dependent hydrolase BF32_3632 ENOG4105CEN a g-specific adenine glycosylase BF32_3633 ENOG4106BXE BF32_3638 ENOG4105BZ1 (ABC) transporter BF32_3639 ENOG4107NBY Membrane BF32_3640 ENOG4105CBC glutamate synthase BF32_3642 ENOG4108IUW ABC transporter BF32_3646 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF32_3647 ENOG4105G5W regulator Fur family BF32_366 ENOG4108IUM Glycogen debranching enzyme BF32_3676 ENOG4105BZ1 (ABC) transporter BF32_3679 ENOG4108JQC penicillin-binding protein 1A BF32_3680 ENOG4107ZQN disulfide bond BF32_3683 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF32_3685 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF32_3688 ENOG4105CYN Serine protein kinase BF32_3692 ENOG4105C94 Transporter BF32_3695 ENOG4105DZ6 Band 7 protein BF32_3697 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF32_3698 ENOG4108V9W transcriptional regulatory protein BF32_3699 ENOG4105D4T Citrate transporter BF32_3703 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF32_3704 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF32_3705 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF32_3706 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF32_3707 ENOG4105BZ7 extracellular solute-binding protein family 1 BF32_3708 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF32_3709 ENOG4108STX response regulator BF32_3710 ENOG4105US7 Histidine kinase BF32_3715 ENOG4108MRH transcriptional regulatory protein BF32_3717 ENOG4105C6K Malic enzyme BF32_3719 ENOG4108UZ3 Transporter BF32_372 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BF32_3720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF32_3722 ENOG4105BZU Histidine kinase BF32_3723 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_3725 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF32_3726 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF32_3727 ENOG4108JB9 formate dehydrogenase BF32_373 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF32_3731 ENOG4105CUB amino acid BF32_3733 ENOG4105C59 p-type ATPase BF32_3734 ENOG4105DAP Nicotinate phosphoribosyltransferase BF32_3741 ENOG41073R8 VanW family BF32_3742 ENOG4108KGH TRANSCRIPTIONal BF32_3743 ENOG4105D9N nucleoside BF32_3744 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF32_3745 ENOG4105C37 (CBS) domain BF32_3746 ENOG4108IJ0 Aspartate ammonia-lyase BF32_3747 ENOG4105DAA L-lactate BF32_375 ENOG4105FDR Membrane BF32_3750 ENOG4105DUX Transporter BF32_3751 ENOG4108MES Periplasmic binding protein BF32_3752 ENOG4105DQ5 transport system permease protein BF32_3753 ENOG4108IHU transport system permease protein BF32_3754 ENOG4105E0A ABC, transporter BF32_3755 ENOG4105DMQ Methyltransferase BF32_3757 ENOG4105EXW epimerase dehydratase BF32_3759 ENOG4107T89 von Willebrand factor, type A BF32_3760 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF32_3761 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF32_3763 ENOG4105BZU Histidine kinase BF32_3764 ENOG4105D5Q Arginine ornithine antiporter BF32_3765 ENOG4107414 GntR family transcriptional regulator BF32_3766 ENOG4105C5Y PTS System BF32_3767 ENOG4105CG3 alpha amylase, catalytic region BF32_3770 ENOG4105E1K spore germination protein BF32_3771 ENOG4108XG2 Histidine kinase BF32_3772 ENOG4105WH1 Two component transcriptional regulator luxr family BF32_3773 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF32_3776 ENOG4105CRN Aminoglycoside phosphotransferase BF32_3777 ENOG4105BZG amino acid carrier protein BF32_3778 ENOG4105CDA abc transporter atp-binding protein BF32_3779 ENOG4105CT1 (ABC) transporter BF32_3780 ENOG4105EAD ABC transporter BF32_3781 ENOG4105DRP amino acid AbC transporter BF32_3782 ENOG4108IQI permease BF32_3787 ENOG4105D29 Helix-turn-helix type 11 domain protein BF32_3788 ENOG4105NAE bifunctional deaminase-reductase domain protein BF32_3789 ENOG4105BZU Histidine kinase BF32_3792 ENOG4105CHH sulfate transporter BF32_3793 ENOG41068KF Universal stress protein BF32_3795 ENOG4105DEF Extracellular solute-binding protein, family 5 BF32_3797 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF32_3798 ENOG4108JQ7 (ABC) transporter BF32_38 ENOG4105EYF MMPL domain protein BF32_3800 ENOG4105CXY transporter BF32_3801 ENOG41067TZ transcriptional regulator, MarR family BF32_3802 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF32_3803 ENOG4105ETE Transcriptional regulator (LacI family BF32_3804 ENOG4108RVA ribokinase BF32_3806 ENOG4105C2J ABC transporter BF32_3807 ENOG4105CNN ABC, transporter BF32_3808 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF32_3809 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF32_3821 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF32_3822 ENOG41069ER domain protein BF32_3823 ENOG4105VZ8 Transcriptional regulator BF32_3824 ENOG4107D63 BF32_3826 ENOG4105DUX Transporter BF32_3831 ENOG4105C85 amino acid BF32_3832 ENOG4105C7N Xanthine uracil vitamin C permease BF32_3835 ENOG4105MA6 gCN5-related N-acetyltransferase BF32_3840 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF32_3841 ENOG4105E2S oxidase) subunit II BF32_3844 ENOG4106CAD Protein of unknown function (DUF3311) BF32_3845 ENOG4105E1V na solute symporter BF32_3848 ENOG4108NHD germination protein BF32_3849 ENOG4105CE1 Ferrous iron transport protein b BF32_3850 ENOG4105CE1 Ferrous iron transport protein b BF32_3851 ENOG4105CE1 Ferrous iron transport protein b BF32_3852 ENOG4105CVA phosphate BF32_3853 ENOG4105C8U phosphate abc transporter BF32_3854 ENOG4105E2Z phosphate ABC transporter (Permease BF32_386 ENOG4105MSI germination protein ypeb BF32_3881 ENOG41080XQ Signal transduction protein with cbs domains BF32_3885 ENOG4105ETU transcriptional activator (TenA BF32_3887 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF32_3889 ENOG4108VEU Thiamine monophosphate synthase BF32_3890 ENOG41080HI glycine oxidase BF32_3893 ENOG4105D06 uba thif-type nad fad binding protein BF32_3894 ENOG4105DWF phosphomethylpyrimidine kinase BF32_3903 ENOG4108INS Transcriptional regulator BF32_3908 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF32_3910 ENOG4105C7N Xanthine uracil vitamin C permease BF32_3912 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF32_3916 ENOG4105C5Y PTS System BF32_3923 ENOG4108B31 Spore germination protein BF32_3927 ENOG4107Y03 Nitroreductase BF32_3928 ENOG4105ED1 spovr family BF32_3929 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF32_393 ENOG4107Z3H Transcriptional regulator, TetR family BF32_3930 ENOG4105XTG Pfam:DUF156 BF32_3931 ENOG4105VFE sira family BF32_3932 ENOG4107TPS domain protein BF32_3933 ENOG4105VFE sira family BF32_3934 ENOG41085GJ domain protein BF32_3936 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF32_3937 ENOG41087NI Sulfite exporter TauE/SafE BF32_3939 ENOG4108KGH TRANSCRIPTIONal BF32_3944 ENOG4105EMD TRANSCRIPTIONal BF32_3945 ENOG4105VCP PTS System BF32_3946 ENOG4105VZJ PTS System BF32_3950 ENOG41069ER domain protein BF32_3951 ENOG4107RBB ABC transporter, permease BF32_3952 ENOG4105C19 ABC transporter BF32_3959 ENOG4105WEF catalase BF32_3966 ENOG4107T5V SNARE associated Golgi BF32_3973 ENOG4105CUB amino acid BF32_3974 ENOG4107RWR Sodium hydrogen exchanger BF32_3976 ENOG4106KNT transcriptional regulator BF32_398 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF32_3985 ENOG4108YXU transcriptional regulator AsnC family BF32_3987 ENOG4105KPY Small multidrug resistance protein BF32_3988 ENOG4105KPY Small multidrug resistance protein BF32_3991 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF32_3992 ENOG4105E5W Transporter BF32_3994 ENOG4107RKG DJ-1/PfpI family BF32_3995 ENOG4105CH6 catalase BF32_3997 ENOG4105D5Q Arginine ornithine antiporter BF32_3998 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF32_4 ENOG4105WQT MbtH domain protein BF32_4000 ENOG4105C26 Dehydrogenase BF32_4001 ENOG4105BZ1 (ABC) transporter BF32_4002 ENOG4105BZ1 (ABC) transporter BF32_4004 ENOG4105DRP amino acid AbC transporter BF32_4005 ENOG4105CDA abc transporter atp-binding protein BF32_4008 ENOG410839P BF32_401 ENOG4108MK9 spermidine N(1)-acetyltransferase BF32_4015 ENOG4107FQX Alpha-acetolactate decarboxylase BF32_4018 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF32_4019 ENOG4105D4P Coproporphyrinogen iii oxidase BF32_402 ENOG4105E98 transcriptional regulator DeoR family BF32_4022 ENOG4105CHH sulfate transporter BF32_4030 ENOG4106AKK s-layer domain-containing protein BF32_4031 ENOG4106AKK s-layer domain-containing protein BF32_4033 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF32_4035 ENOG4105CGU Enoyl-CoA hydratase BF32_4039 ENOG4105DER m42 family BF32_4043 ENOG4105CTU Proline racemase BF32_4048 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF32_4050 ENOG4108JQ7 (ABC) transporter BF32_4059 ENOG4105CSH Transporter BF32_406 ENOG41062ES Transcriptional regulator BF32_4061 ENOG4108MRH transcriptional regulatory protein BF32_4074 ENOG4105CDU Replicative dna helicase BF32_4079 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF32_4092 ENOG4107P5I polyketide synthase BF32_4093 ENOG4108IG5 Transcriptional regulator BF32_4096 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF32_410 ENOG4107QKR Dehydrogenase BF32_4102 ENOG4105CMT Dihydroxyacetone kinase BF32_4104 ENOG4105CMT Dihydroxyacetone kinase BF32_4105 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BF32_4106 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF32_4109 ENOG410780I phosphoprotein phosphatase activity BF32_4111 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF32_412 ENOG4107RUY (E1 component), alpha subunit BF32_4123 ENOG4105WN5 stage II sporulation protein BF32_4125 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF32_4127 ENOG4108MJI response regulator BF32_4128 ENOG4105BZU Histidine kinase BF32_4129 ENOG4105BZU Histidine kinase BF32_4134 ENOG4105K8R UPF0145 protein BF32_4137 ENOG4105ENE Histidine kinase BF32_4138 ENOG4108VB1 regulatoR BF32_414 ENOG4105E1F short-chain dehydrogenase reductase BF32_4144 ENOG4107VRP DNA repair exonuclease BF32_4145 ENOG4106D4I domain protein BF32_415 ENOG4105RHY Pfam:UPF0157 BF32_4155 ENOG4108MUZ hydrolase BF32_4159 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF32_416 ENOG4105DBI uridine monophosphokinase BF32_4162 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF32_4167 ENOG4105EMN RNA polymerase sigma factor BF32_4172 ENOG4105C57 major facilitator superfamily BF32_4173 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF32_4175 ENOG4105EEM helicase BF32_4176 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF32_418 ENOG4105M6F mutator MutT protein BF32_4181 ENOG4105K59 histidine triad (HIT) protein BF32_4188 ENOG410905X membrane-flanked domain protein BF32_4189 ENOG4105CKV Membrane BF32_4193 ENOG41060BG Tetr family transcriptional regulator BF32_4197 ENOG410905X membrane-flanked domain protein BF32_4198 ENOG4105CKV Membrane BF32_4199 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF32_4200 ENOG4105BZ4 penicillin-binding protein BF32_4203 ENOG4105C1Q protoporphyrinogen oxidase BF32_4209 ENOG4105NA0 Transcriptional regulator BF32_4212 ENOG4105ECB domain protein BF32_4213 ENOG4105ECB domain protein BF32_4219 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BF32_4221 ENOG4105D29 Helix-turn-helix type 11 domain protein BF32_4223 ENOG4106AXD BF32_4224 ENOG4108RQ5 Beta-lactamase domain-containing protein BF32_4225 ENOG4105DF9 Lipoate-protein, ligase BF32_4227 ENOG4105CEY Amp-dependent synthetase and ligase BF32_4239 ENOG4105ENX hydrolase BF32_424 ENOG4108IJ7 Glycine betaine BF32_4240 ENOG4107RN3 metallophosphoesterase BF32_4242 ENOG4107TVP HD domain protein BF32_4244 ENOG4108AEY RNA polymerase sigma factor BF32_4245 ENOG41086D8 Transcriptional regulator BF32_4247 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_4251 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF32_4255 ENOG4105ZU5 s-layer protein BF32_4256 ENOG4107QP3 malate synthase g BF32_4259 ENOG4105VEQ Cold shock protein BF32_4262 ENOG4105XVF Competence transcription factor BF32_4276 ENOG4105ERH Fumarylacetoacetate hydrolase BF32_4281 ENOG4105CAQ asparagine synthetase BF32_4282 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF32_4283 ENOG4105CH6 catalase BF32_4284 ENOG4105BZU Histidine kinase BF32_4288 ENOG4105QNR S1 RNA binding domain protein BF32_429 ENOG4105E66 phosphoriboisomerase A BF32_4290 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF32_4292 ENOG4107AYK membrAne BF32_4293 ENOG41073B9 BF32_4295 ENOG4108KP7 hydrolase BF32_4297 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF32_43 ENOG4105WCN acetyltransferase BF32_430 ENOG41082BV acetyltransferase BF32_4302 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF32_4303 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF32_4306 ENOG4105C31 Tryptophanyl-tRNA synthetase BF32_4309 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF32_431 ENOG4108M1A Chitin-binding protein BF32_4310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF32_4312 ENOG4108JQ7 (ABC) transporter BF32_4313 ENOG4105UQX Mate efflux family protein BF32_4317 ENOG4108ZCF integral membrane protein BF32_4319 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF32_4321 ENOG4105DPN Oligoendopeptidase f BF32_4324 ENOG4108Z18 K06886 hemoglobin BF32_4325 ENOG4105MIX Adenylate cyclase BF32_4328 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF32_4329 ENOG4105EMS pseudouridine synthase BF32_4333 ENOG4105K64 Glycosyl transferase, family 2 BF32_4337 ENOG4107TVC Glycosyl transferase, family 2 BF32_434 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF32_4341 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF32_4342 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF32_4344 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF32_435 ENOG4105MSB protein, conserved in bacteria BF32_4358 ENOG4105CK7 Sodium proline symporter BF32_4359 ENOG4105CRQ synthase (Component I) BF32_436 ENOG4107YB6 acetyltransferase, (GNAT) family BF32_4360 ENOG4105DDQ anthranilate synthase BF32_437 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF32_4377 ENOG4105C7S Dehydrogenase BF32_4379 ENOG4105VZ8 Transcriptional regulator BF32_4403 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF32_4406 ENOG4108IUX (ABC) transporter BF32_4407 ENOG4105RHA ABC transporter, permease BF32_4416 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF32_4419 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF32_4421 ENOG4105DZ1 carboxypeptidase BF32_4422 ENOG4105VFR signal peptidase BF32_4428 ENOG4105C26 Dehydrogenase BF32_443 ENOG4108Z7F N-acetyltransferase BF32_4430 ENOG4105F38 ABC transporter, permease BF32_4431 ENOG4105D38 putrescine abc transporter BF32_4432 ENOG4107RUE extracellular solute-binding protein family 1 BF32_4434 ENOG4105EYF MMPL domain protein BF32_4436 ENOG4108YBP pseudouridine synthase BF32_4438 ENOG4105K4I Scp-like extracellular BF32_4439 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF32_4440 ENOG4105CQB FAD linked oxidase domain protein BF32_4443 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_4444 ENOG4105BZU Histidine kinase BF32_4445 ENOG4105JXH GntR family transcriptional regulator BF32_4449 ENOG4106A3R peptidase BF32_4451 ENOG4108QTI )-transporter BF32_4452 ENOG4107TS3 membrane protein, TerC BF32_4453 ENOG4105CZN Potassium uptake protein BF32_4454 ENOG410681C small acid-soluble spore protein BF32_4455 ENOG4108Z7G MaoC domain protein dehydratase BF32_4459 ENOG4105CHR reductase BF32_4461 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF32_4465 ENOG4105C4Y ABC transporter BF32_4466 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF32_4467 ENOG4107RCV ABC transporter, permease BF32_447 ENOG4105EEM helicase BF32_4471 ENOG4105E98 transcriptional regulator DeoR family BF32_4474 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF32_4476 ENOG4105PXI polysaccharide deacetylase BF32_4478 ENOG4105BZU Histidine kinase BF32_4479 ENOG41090MY MarR family Transcriptional regulator BF32_4481 ENOG4106DF1 BF32_4483 ENOG4105BZU Histidine kinase BF32_4485 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF32_4486 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF32_4494 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF32_4495 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF32_4496 ENOG41079K6 HNH endonuclease BF32_4497 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF32_4498 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF32_4499 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF32_4500 ENOG4105CZV ABC transporter BF32_4502 ENOG4105CJ1 ABC, transporter BF32_451 ENOG4105C9U ATP-dependent DNA helicase RecQ BF32_4510 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF32_4511 ENOG4105EA8 2-Nitropropane dioxygenase BF32_4512 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF32_4514 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF32_4519 ENOG4105NQC Flavodoxin BF32_4526 ENOG4107QMU Mate efflux family protein BF32_4527 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF32_4533 ENOG4105CZN Potassium uptake protein BF32_4534 ENOG41063Y9 BF32_4535 ENOG4105KBJ sporulation protein ytfj BF32_4540 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF32_4541 ENOG4105C7K acetolactate synthase BF32_4542 ENOG4108ZP8 Acetolactate synthase small subunit BF32_4557 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF32_4559 ENOG4105C5I Dehydrogenase BF32_4560 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF32_4561 ENOG4105E0M Sulfatase BF32_4563 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF32_4567 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF32_4568 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF32_4570 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF32_4571 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF32_4572 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF32_4573 ENOG4105C8J )-transporter BF32_4577 ENOG4105DFD Na H antiporter BF32_4581 ENOG4105ENE Histidine kinase BF32_4582 ENOG4105WH1 Two component transcriptional regulator luxr family BF32_4586 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF32_4595 ENOG4105CJ3 phosphate transporter BF32_4596 ENOG4107GRR phosphate transport regulator BF32_4597 ENOG4105BZ4 penicillin-binding protein BF32_460 ENOG4108M1A Chitin-binding protein BF32_4600 ENOG4105BZU Histidine kinase BF32_4601 ENOG4105I3N Conserved Protein BF32_4604 ENOG4105BZU Histidine kinase BF32_4610 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF32_4611 ENOG4105DZ1 carboxypeptidase BF32_4612 ENOG4108JIC nucleoside recognition domain protein BF32_4614 ENOG4105FE9 pseudouridine synthase BF32_4616 ENOG4107TWT Cytochrome c biogenesis protein BF32_4617 ENOG4105CRE cytochrome C BF32_4618 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_4619 ENOG4105BZU Histidine kinase BF32_4620 ENOG4108WBT adenosyltransferase BF32_4621 ENOG41063SB peptidase BF32_4623 ENOG4108SAX Membrane BF32_4626 ENOG4105C9U ATP-dependent DNA helicase RecQ BF32_4627 ENOG4105I7S Abortive infection protein BF32_4629 ENOG4107RGJ metallophosphoesterase BF32_463 ENOG4105BZG amino acid carrier protein BF32_4630 ENOG4107X2D transcriptional regulator, merr family BF32_4631 ENOG4108S6Z Negative regulator of genetic competence BF32_4636 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF32_4637 ENOG4107RB3 L-asparaginase BF32_464 ENOG4105C26 Dehydrogenase BF32_4644 ENOG4105S2F BF32_4645 ENOG41065D1 BF32_465 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF32_4651 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF32_4654 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF32_4656 ENOG4105EAH synthase BF32_466 ENOG4105CTU Proline racemase BF32_4660 ENOG4105CIH Imidazole acetol-phosphate transaminase BF32_4661 ENOG41068YB TPR repeat-containing protein BF32_4664 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF32_4665 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF32_4666 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF32_467 ENOG4105CTU Proline racemase BF32_4672 ENOG4108JYZ YitT family BF32_4673 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF32_4676 ENOG4105FJR Lmbe family BF32_4677 ENOG4105CPK Glycosyl transferase (Group 1 BF32_468 ENOG41080HI glycine oxidase BF32_4684 ENOG4105DVT helicase BF32_4685 ENOG4105YAC BF32_4689 ENOG4105CSM endonuclease III BF32_4691 ENOG4105BZ4 penicillin-binding protein BF32_470 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BF32_4702 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF32_4704 ENOG4105DVT helicase BF32_4705 ENOG4105CTD carboxy-peptidase BF32_4708 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF32_4710 ENOG4105C2W permease BF32_4711 ENOG4105DHF Membrane BF32_4713 ENOG410890F Dynamin family BF32_4715 ENOG4108W0I acetyltransferase BF32_4717 ENOG4105KHC sulfurtransferase BF32_4720 ENOG4106032 Glutathionylspermidine synthase BF32_4726 ENOG4108SZE gCN5-related N-acetyltransferase BF32_4730 ENOG41081VK Ribonuclease BF32_4743 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF32_4745 ENOG4107RWR Sodium hydrogen exchanger BF32_4746 ENOG4105CN5 Metallo-Beta-Lactamase BF32_4747 ENOG4108Z5V transcriptional regulator, merr family BF32_4749 ENOG4105H67 Protein of unknown function (DUF421) BF32_4750 ENOG41080C8 DUF218 domain BF32_476 ENOG4107T5V SNARE associated Golgi BF32_4761 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF32_4763 ENOG4107R0U MotA TolQ exbB proton channel BF32_4764 ENOG4105ER2 Ompa motb domain protein BF32_4765 ENOG4107YTP response regulator receiver protein BF32_4766 ENOG4105CBS Chea signal transduction histidine kinase BF32_4767 ENOG4105DD5 Flagellar motor switch protein BF32_4770 ENOG4105BZU Histidine kinase BF32_4774 ENOG4105E1Q flagellar hook-associated protein BF32_4775 ENOG4105DTJ flagellar hook-associated protein BF32_4776 ENOG4107TPX flagellar hook-associated BF32_4779 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF32_4780 ENOG4108ZC9 flagellar basal-body rod protein flgc BF32_4781 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF32_4782 ENOG4107U2N Flagellar M-ring protein BF32_4783 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF32_4789 ENOG4105BZE flagellar hook protein, FlgE BF32_479 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF32_4792 ENOG4107R88 Chemotaxis protein (CheV) BF32_4794 ENOG4105I03 Flagellin BF32_4795 ENOG4105I03 Flagellin BF32_4796 ENOG4105E4C Lytic transglycosylase catalytic BF32_4798 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF32_4799 ENOG4105DD5 Flagellar motor switch protein BF32_480 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF32_4801 ENOG4105CN7 Flagellar biosynthetic protein FliP BF32_4802 ENOG4105VS8 Flagellar biosynthetic protein fliq BF32_4804 ENOG4105D00 flagellar biosynthetic protein flhB BF32_4805 ENOG4105D7B Flagellar biosynthesis protein flha BF32_4806 ENOG4105FZW flagellar biosynthesis regulator FlhF BF32_4807 ENOG4105KTQ flagellar basal-body rod protein BF32_4808 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF32_4813 ENOG41062JF Transcriptional regulator BF32_4819 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF32_4824 ENOG4105DUM transcriptional regulator, lysR family BF32_4825 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF32_4827 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF32_4828 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF32_483 ENOG4105DTQ mandelate racemase muconate lactonizing BF32_4836 ENOG4105CVJ phosphoglycerate mutase BF32_4840 ENOG4105K56 Transcriptional regulator BF32_4842 ENOG4105CAQ asparagine synthetase BF32_4846 ENOG4105PGM cation diffusion facilitator family transporter BF32_4848 ENOG4105DRR Transcriptional regulator, GntR family BF32_4849 ENOG4108UZ3 Transporter BF32_4850 ENOG4105CKI cobalamin synthesis protein BF32_4851 ENOG4108PJD permease BF32_4854 ENOG4105DFD Na H antiporter BF32_4855 ENOG4105C9Q fumarate hydratase class II BF32_4858 ENOG4107QJQ Mate efflux family protein BF32_4859 ENOG4105EC3 peptidase S51, dipeptidase E BF32_4863 ENOG4107QIV Cytochrome c biogenesis protein BF32_4869 ENOG4106BRA Membrane BF32_4876 ENOG4105CJ1 ABC, transporter BF32_4880 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF32_4882 ENOG4108IJ0 Aspartate ammonia-lyase BF32_4883 ENOG4105C6K Malic enzyme BF32_4889 ENOG41067QW Transcriptional regulator BF32_4893 ENOG4105FVX BF32_49 ENOG4105C1Q protoporphyrinogen oxidase BF32_4900 ENOG4105CSR polyphosphate kinase 2 BF32_4901 ENOG4105DXI Major Facilitator superfamily BF32_4904 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF32_4906 ENOG4105EU0 Major facilitator Superfamily BF32_4907 ENOG4105C6T cysteine synthase BF32_4911 ENOG4105C8J )-transporter BF32_4913 ENOG4105X5K response regulator receiver protein BF32_4914 ENOG4105H67 Protein of unknown function (DUF421) BF32_4916 ENOG4106KE4 Dehydrogenase BF32_492 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF32_4920 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF32_4921 ENOG4105CHR reductase BF32_4922 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF32_4923 ENOG4105C7K acetolactate synthase BF32_4925 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF32_4927 ENOG4105C7B Threonine dehydratase BF32_493 ENOG4105BZU Histidine kinase BF32_4932 ENOG4105C6X Major Facilitator BF32_4933 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF32_4937 ENOG4105DY9 regulatoR BF32_4938 ENOG4105CYC Transferase BF32_494 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_4942 ENOG4108IBT Inherit from COG: transposase BF32_4950 ENOG41068WN BF32_4951 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_4955 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF32_4958 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF32_4960 ENOG4105C0X amino acid BF32_4969 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_4971 ENOG4107RHR regulatoR BF32_4973 ENOG4105D9N nucleoside BF32_4974 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF32_4980 ENOG4107RAQ aminopeptidase BF32_4981 ENOG4107R16 Multicopper oxidase BF32_4990 ENOG4108T5E Copper resistance protein BF32_4991 ENOG4105KTB nuclear export factor GLE1 BF32_4992 ENOG4107RT3 EamA-like transporter family BF32_4993 ENOG4105GZI Transcriptional regulator BF32_4994 ENOG4108Z40 Transcriptional regulator BF32_4995 ENOG4107ZXU DSBA oxidoreductase BF32_4996 ENOG4108TVJ Nitroreductase BF32_4998 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF32_4999 ENOG4106F5Q Membrane BF32_5 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF32_500 ENOG4105DPN Oligoendopeptidase f BF32_5000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF32_5002 ENOG4105CKI cobalamin synthesis protein BF32_5006 ENOG4108Z7G MaoC domain protein dehydratase BF32_5007 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF32_5009 ENOG4105C0Z ABC transporter BF32_501 ENOG4105DVH amino acid BF32_5010 ENOG4108IV0 ABC, transporter BF32_5011 ENOG4105C32 Amino acid ABC transporter (Permease) BF32_5013 ENOG4105EGI Transcriptional regulator BF32_5019 ENOG4105C4M (Ubiquinol oxidase) subunit I BF32_5020 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF32_5021 ENOG4108JJ9 ABC, transporter BF32_5022 ENOG4108JJ8 (ABC) transporter BF32_5029 ENOG4105BZ1 (ABC) transporter BF32_503 ENOG4105EPR degv family BF32_5030 ENOG4105EFI regulatoR BF32_5031 ENOG4105EB3 Histidine kinase BF32_5034 ENOG4108VQJ O-methyltransferase BF32_5035 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF32_5036 ENOG4108ZJ4 polysaccharide deacetylase BF32_5040 ENOG4105D6E homoserine dehydrogenase BF32_5045 ENOG4108KGH TRANSCRIPTIONal BF32_5047 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF32_5048 ENOG4105BZU Histidine kinase BF32_5049 ENOG4107VMI polysaccharide deacetylase BF32_5051 ENOG4105KT7 mgtC SapB transporter BF32_5052 ENOG4105VRR gCN5-related N-acetyltransferase BF32_5054 ENOG4105DUU IucA IucC family protein BF32_5055 ENOG4105CEY Amp-dependent synthetase and ligase BF32_5058 ENOG4108WBH protein TIM barrel BF32_5059 ENOG4105YWU small acid-soluble spore protein BF32_5061 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF32_5062 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF32_5072 ENOG4105KRN Transcriptional regulator, abrb family BF32_5074 ENOG4105YVS arsR family transcriptional regulator BF32_5075 ENOG4107SET aldo keto reductase BF32_5076 ENOG4107XZQ multidrug resistance protein BF32_5081 ENOG4105C8Q Methyl-accepting chemotaxis BF32_5084 ENOG4108K88 Membrane BF32_5085 ENOG4108WPJ Ferritin-like domain BF32_5088 ENOG4105DEN Luciferase family BF32_5092 ENOG4107QM2 Aldo Keto reductase BF32_5093 ENOG4105CKI cobalamin synthesis protein BF32_5097 ENOG4108IBT Inherit from COG: transposase BF32_5098 ENOG4105DSE periplasmic solute binding protein BF32_51 ENOG41089UC methyltransferase, type 11 BF32_5100 ENOG4105K4T epimerase BF32_5102 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF32_5107 ENOG4105CVJ phosphoglycerate mutase BF32_5111 ENOG4107T5V SNARE associated Golgi BF32_5114 ENOG4108PJD permease BF32_5116 ENOG4108S4H thioesterase Superfamily protein BF32_5117 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF32_5121 ENOG4105SXS Protein of unknown function (DUF456) BF32_5122 ENOG4105C37 (CBS) domain BF32_5126 ENOG4108Z7R Chaperone CsaA BF32_5129 ENOG4108ZRV stage ii sporulation protein p BF32_5131 ENOG4108VXD carboxy-peptidase BF32_5137 ENOG4105EFA 4-hydroxyphenylacetate BF32_5139 ENOG4105U1N riboflavin BF32_514 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF32_5142 ENOG4105KME endoribonuclease L-psp BF32_5148 ENOG41069HH 4-oxalocrotonate tautomerase BF32_515 ENOG4106K7D Major facilitator family transporter BF32_5150 ENOG4108X4Q Hydrolase BF32_5152 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF32_5153 ENOG4107RBS Methyltransferase BF32_5156 ENOG41087PP glycosyltransferase MGT family BF32_5157 ENOG4108JYZ YitT family BF32_5158 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF32_5163 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF32_5179 ENOG4105KBJ sporulation protein ytfj BF32_5184 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF32_5188 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF32_5189 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BF32_5191 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF32_5192 ENOG4105EMN RNA polymerase sigma factor BF32_5195 ENOG4105CNW domain protein BF32_5197 ENOG4108V06 Glutathione peroxidase BF32_52 ENOG41068WN BF32_520 ENOG4107BMA Transglycosylase associated protein BF32_5200 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF32_5204 ENOG4108IUE nitrate reductase beta subunit BF32_5205 ENOG4105R3A Nitrate reductase BF32_5207 ENOG4107V6Q Cyclic nucleotide-binding domain BF32_5208 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF32_5209 ENOG4105D06 uba thif-type nad fad binding protein BF32_5210 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF32_5211 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF32_5212 ENOG4108ZAF Molybdopterin BF32_5216 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF32_5217 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF32_5218 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF32_5219 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF32_5220 ENOG4108IFG nitrite reductase, (NAD(P)H) BF32_5221 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF32_5226 ENOG4105MCT stage V sporulation protein S BF32_523 ENOG41089UC methyltransferase, type 11 BF32_5235 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF32_5241 ENOG4105C5H ABC transporter BF32_5244 ENOG4108UUM single-stranded DNA-binding protein BF32_5250 ENOG4107YX5 Pfam:DUF548 BF32_5258 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF32_5259 ENOG4105C5S asparaginyl-tRNA synthetase BF32_5263 ENOG4105EC2 ftsk spoIIIe BF32_5286 ENOG4105BZW Glycerate kinase BF32_5287 ENOG4107QPK )-transporter BF32_5288 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_5289 ENOG41062D9 Histidine kinase BF32_529 ENOG4105CHM Aminotransferase BF32_5292 ENOG4105C8J )-transporter BF32_5296 ENOG4107XGZ Hydrolase BF32_5297 ENOG4105CY2 Citrate transporter BF32_5298 ENOG4105C0A alcohol dehydrogenase BF32_5300 ENOG4108R96 Methyltransferase, YaeB family BF32_5301 ENOG4105KD7 acetyltransferase BF32_5302 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF32_5307 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF32_5311 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF32_5315 ENOG4107RVG penicillin-binding protein BF32_5317 ENOG4105E9Q Acyl-transferase BF32_5318 ENOG4108UT2 hemolysin iii BF32_532 ENOG4108ZMI UPF0477 protein BF32_5320 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF32_5322 ENOG4108RCR degv family BF32_5323 ENOG4105E8R UPF0173 metal-dependent hydrolase BF32_5324 ENOG4108KF3 Electron transport protein SCO1 SenC BF32_5325 ENOG4107Y70 Heat shock protein BF32_5326 ENOG4105CAQ asparagine synthetase BF32_5330 ENOG4108MES Periplasmic binding protein BF32_5331 ENOG4105F0I Aminotransferase BF32_5338 ENOG4105D8X mechanosensitive ion channel BF32_5339 ENOG4105BZU Histidine kinase BF32_5340 ENOG4105WH1 Two component transcriptional regulator luxr family BF32_5341 ENOG4106KNT transcriptional regulator BF32_5347 ENOG4105CMG Carbohydrate kinase BF32_535 ENOG4105DVE abc transporter atp-binding protein BF32_5353 ENOG4108IJ8 ABC transporter BF32_5354 ENOG4105E90 ABC transporter BF32_5361 ENOG4105C37 (CBS) domain BF32_5366 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF32_5369 ENOG4107S4Y M20 DapE family protein YgeY BF32_5370 ENOG4108TSC N-acetyltransferase BF32_5371 ENOG4108JUB Transcriptional regulator BF32_5372 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF32_5380 ENOG4108N23 SpoOM-related protein BF32_5382 ENOG410841Q phosphoesterase PA-phosphatase related protein BF32_5383 ENOG4105SZ6 Thioredoxin BF32_5394 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF32_54 ENOG4105VEQ Cold shock protein BF32_5405 ENOG4105BZ4 penicillin-binding protein BF32_5406 ENOG4105CZM Major Facilitator BF32_5408 ENOG4105W8X HesB YadR YfhF-family protein BF32_5410 ENOG4105DXD 2-methylcitrate dehydratase BF32_5411 ENOG4105CR4 methylisocitrate lyase BF32_5412 ENOG4105C1G acyl-Coa dehydrogenase BF32_5413 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF32_5415 ENOG4105N14 lysine exporter protein LysE YggA BF32_5416 ENOG4105E39 Enoyl-CoA hydratase BF32_5419 ENOG4107RFY SbcCD D subunit BF32_5420 ENOG4105EYH Exonuclease BF32_5424 ENOG4105FCD Major Facilitator BF32_5425 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF32_5426 ENOG4105E4F Isochorismate synthase BF32_543 ENOG4105C02 permease BF32_5431 ENOG41060SN BF32_5448 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF32_545 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF32_5456 ENOG4107QJE Chromosome Partitioning Protein BF32_546 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF32_547 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF32_5470 ENOG4105WXW Antirepressor BF32_5480 ENOG4106CVF DNA replication protein BF32_5496 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BF32_550 ENOG4105E09 nadh pyrophosphatase BF32_5501 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF32_5503 ENOG4108TFU terminase (Small subunit) BF32_5505 ENOG4108MDF Phage Portal Protein BF32_5506 ENOG4106CGH Phage Mu protein F like protein BF32_554 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF32_568 ENOG4108ZCF integral membrane protein BF32_569 ENOG4105E0M Sulfatase BF32_570 ENOG4105C5H ABC transporter BF32_572 ENOG4105EYF MMPL domain protein BF32_573 ENOG41082JN Transcriptional regulator BF32_577 ENOG4105CIH Imidazole acetol-phosphate transaminase BF32_579 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF32_587 ENOG41069ER domain protein BF32_589 ENOG4105CY2 Citrate transporter BF32_59 ENOG4107V2S Transcriptional regulator BF32_590 ENOG4105E39 Enoyl-CoA hydratase BF32_591 ENOG4105J5T Amp-dependent synthetase and ligase BF32_592 ENOG4108JUB Transcriptional regulator BF32_596 ENOG4105D4B ABC, transporter BF32_597 ENOG4105F5R ABC transporter BF32_598 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF32_60 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF32_600 ENOG4105DKT Transcriptional regulator BF32_601 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF32_603 ENOG41061GT Aldolase BF32_608 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF32_615 ENOG4105II7 pyrroline-5-carboxylate reductase BF32_617 ENOG4107258 Transcriptional regulator BF32_619 ENOG4105E0Y RtcB Protein BF32_620 ENOG4105ECK Fatty Acid Desaturase BF32_621 ENOG4105G6Z alkaline phosphatase BF32_623 ENOG4105VMP Transcriptional regulator BF32_626 ENOG41090T1 Membrane BF32_628 ENOG4108WCX response regulator BF32_63 ENOG4105DND Transcriptional regulator BF32_630 ENOG41068WN BF32_635 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF32_64 ENOG4108RPX mosc domain containing protein BF32_644 ENOG4105CKK Glycosyl transferase, family 2 BF32_646 ENOG4105C8Y Acetylornithine aminotransferase BF32_647 ENOG4105CH6 catalase BF32_656 ENOG4108TVJ Nitroreductase BF32_657 ENOG4105FS7 Transcriptional regulator BF32_664 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF32_667 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BF32_67 ENOG4105BZ1 (ABC) transporter BF32_673 ENOG4108XET gCN5-related N-acetyltransferase BF32_68 ENOG4105BZ1 (ABC) transporter BF32_685 ENOG410635A Membrane BF32_686 ENOG4105KNA -acetyltransferase BF32_687 ENOG4108IQI permease BF32_689 ENOG4105F1N DNA alkylation repair BF32_696 ENOG4107RF6 penicillin-binding protein BF32_704 ENOG4105P4J Allophanate hydrolase, subunit 1 BF32_705 ENOG4107258 Transcriptional regulator BF32_707 ENOG4106N3A copper homeostasis protein cutc BF32_708 ENOG4108ZRV stage ii sporulation protein p BF32_709 ENOG4108ZHR arsR family transcriptional regulator BF32_711 ENOG4105FDT acyl-CoA dehydrogenase BF32_715 ENOG4105DWD nucleoside recognition domain protein BF32_72 ENOG4108JCI Transcriptional regulator BF32_721 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF32_722 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF32_736 ENOG4105E2A Dehydrogenase BF32_738 ENOG4108IJ0 Aspartate ammonia-lyase BF32_739 ENOG4105HDK L-asparaginase BF32_740 ENOG4108IMY Transcriptional regulator BF32_743 ENOG4108B31 Spore germination protein BF32_745 ENOG4105BZU Histidine kinase BF32_750 ENOG41075H3 AraC family transcriptional regulator BF32_751 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF32_752 ENOG4105CUB amino acid BF32_753 ENOG4105II7 pyrroline-5-carboxylate reductase BF32_756 ENOG4105CSV Glutaminase BF32_764 ENOG4105CGH 5'-nucleotidase BF32_765 ENOG41061CK Antibiotic biosynthesis monooxygenase BF32_773 ENOG4108606 TspO/MBR family BF32_774 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF32_777 ENOG4108TWJ NADH dehydrogenase subunit 5 BF32_778 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF32_78 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF32_781 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF32_782 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF32_783 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF32_786 ENOG4105C19 ABC transporter BF32_789 ENOG4108NEV two component transcriptional regulator, LytTR family BF32_790 ENOG4105DSE periplasmic solute binding protein BF32_791 ENOG4105CC5 ABC transporter BF32_792 ENOG4105DIK (ABC) transporter BF32_797 ENOG4105D6J arsenicaL-resistance protein BF32_798 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF32_799 ENOG41085FC arsR family transcriptional regulator BF32_8 ENOG4105K70 DNA-binding protein BF32_803 ENOG4105F7F Chaperone BF32_81 ENOG4108KPJ rna polymerase sigma factor BF32_811 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF32_812 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF32_814 ENOG4105IIP Membrane BF32_817 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF32_818 ENOG41062D9 Histidine kinase BF32_823 ENOG4105K6H D-cysteine desulfhydrase BF32_828 ENOG4108NNI Beta-lactamase domain-containing protein BF32_829 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF32_831 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF32_834 ENOG4105C88 aminopeptidase BF32_836 ENOG4105W1Y Transcriptional regulator BF32_837 ENOG4105JQZ Methyltransferase BF32_841 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF32_844 ENOG4105BZU Histidine kinase BF32_847 ENOG4108U05 Transcriptional regulator BF32_848 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BF32_850 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF32_853 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF32_856 ENOG4105CEP NADH dehydrogenase BF32_857 ENOG4105D4Y metalloprotease BF32_858 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF32_86 ENOG4105F32 YngK protein BF32_867 ENOG4105TRI Hydrolase BF32_875 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF32_879 ENOG4105C44 Serine transporter BF32_880 ENOG4105EJQ L-serine dehydratase BF32_882 ENOG4105MZU cell filamentation protein BF32_883 ENOG4108JPW Aminotransferase BF32_886 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF32_888 ENOG4105DVH amino acid BF32_892 ENOG4108JQ1 Dehydrogenase BF32_896 ENOG41082W1 Cupin 2, conserved barrel domain protein BF32_897 ENOG410874W AraC family transcriptional regulator BF32_900 ENOG4108IBT Inherit from COG: transposase BF32_903 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF32_91 ENOG4105RD7 BadF BadG BcrA BcrD BF32_911 ENOG4108ISG Major Facilitator BF32_913 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF32_914 ENOG4105CZM Major Facilitator BF32_918 ENOG4105DA5 (ABC) transporter BF32_919 ENOG41069JR BF32_921 ENOG4105RXJ BF32_922 ENOG4105KPY Small multidrug resistance protein BF32_923 ENOG4105KBX Transcriptional regulator, TetR family BF32_924 ENOG4107AUC BF32_926 ENOG4105CRW Short chain fatty acid transporter BF32_928 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF32_93 ENOG4107STF Involved in phosphonate degradation (By similarity) BF32_935 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF32_940 ENOG4108K8S endonuclease I BF32_941 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF32_942 ENOG4105D7V transposase BF32_946 ENOG4105DSE periplasmic solute binding protein BF32_947 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF32_950 ENOG4108Z66 YbaK ebsC protein BF32_952 ENOG4105WH1 Two component transcriptional regulator luxr family BF32_956 ENOG4105KVH Transcriptional regulator BF32_957 ENOG4108RCM Nitroreductase BF32_961 ENOG4108PSK reductase BF32_963 ENOG4105CJ1 ABC, transporter BF32_969 ENOG4105D7V transposase BF32_977 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF32_978 ENOG4105DKQ ROK family BF32_979 ENOG4106UW1 Major Facilitator superfamily BF32_98 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF32_980 ENOG4108UW5 maltose o-acetyltransferase BF32_985 ENOG4105DMQ Methyltransferase BF32_987 ENOG4105EV4 Multidrug resistance protein mdtH BF32_993 ENOG4105C37 (CBS) domain BF32_996 ENOG4105DDN Pentapeptide repeat-containing protein BF32_997 ENOG4105XDF Protein of unknown function (DUF1272) BF32_998 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF32_999 ENOG4105CMG Carbohydrate kinase