locus-tag class description BF36_1 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF36_1009 ENOG4105CG3 alpha amylase, catalytic region BF36_101 ENOG4105KA0 thioesterase Superfamily protein BF36_1011 ENOG4107FKK extracellular solute-binding protein family 1 BF36_1013 ENOG4105EG2 ABC transporter, permease BF36_1014 ENOG4105FKQ transcriptional regulator BF36_1015 ENOG4105CHM Aminotransferase BF36_1017 ENOG4108HGU Histidine kinase BF36_102 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BF36_1028 ENOG4105UIN BF36_1030 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BF36_1033 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BF36_1034 ENOG4105EPM Diguanylate phosphodiesterase BF36_1037 ENOG4107IN1 Protein of unknown function (DUF1797) BF36_1039 ENOG4108XRC Protein of unknown function (DUF458) BF36_1046 ENOG4107ZYR domain protein BF36_1047 ENOG4105CN5 Metallo-Beta-Lactamase BF36_1049 ENOG4108X4Q Hydrolase BF36_105 ENOG4107R3E Citrate transporter BF36_1050 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF36_1053 ENOG4105CPP Dehydrogenase, E1 component BF36_1063 ENOG4105CXN decarboxylase BF36_1067 ENOG4105ECY inositol monophosphatase BF36_1069 ENOG4105CI3 gtp-binding protein typa BF36_107 ENOG4105Y38 Kinase-associated protein B BF36_1070 ENOG4105QA2 BF36_1074 ENOG4108IAB Phoh family BF36_1077 ENOG4105CNI cell division protein FtsW BF36_1078 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BF36_1088 ENOG4106UY4 Inherit from COG: Scp-like extracellular BF36_1091 ENOG4107TB6 phosphoglycerate mutase BF36_1095 ENOG4106H78 methyltransferase BF36_1096 ENOG4105H20 Sporulation integral membrane protein YlbJ BF36_1098 ENOG4105D78 K07001 NTE family protein BF36_1099 ENOG41063PX domain protein BF36_110 ENOG4105C87 Aminotransferase class I and II BF36_1101 ENOG4105KNH Nucleic acid-binding protein BF36_1108 ENOG41068DC Essential cell division protein (By similarity) BF36_1109 ENOG4105CJN penicillin-binding protein BF36_1110 ENOG4105CJN penicillin-binding protein BF36_1111 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF36_1114 ENOG4105CNI cell division protein FtsW BF36_1115 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF36_1116 ENOG4105D4A Cell wall formation (By similarity) BF36_1117 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BF36_1118 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BF36_1119 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BF36_112 ENOG4108MUZ hydrolase BF36_1121 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF36_1123 ENOG4105WR5 sporulation protein, YlmC YmxH family BF36_1124 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BF36_1125 ENOG4105DFA alanine racemase domain protein BF36_1127 ENOG41067XK integral membrane protein BF36_1128 ENOG4105DBK s4 domain protein BF36_113 ENOG4105C5I Dehydrogenase BF36_1133 ENOG4105C34 Pseudouridine synthase BF36_1138 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BF36_114 ENOG4108ZB6 transcriptional regulator AsnC family BF36_1149 ENOG4105DC7 peptidase M24 BF36_115 ENOG4105CHM Aminotransferase BF36_1150 ENOG4105F23 Fibronectin-binding protein BF36_1152 ENOG4105DSJ YicC domain protein BF36_1156 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BF36_1157 ENOG4105C25 Primosomal protein n' BF36_1158 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BF36_1160 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BF36_1162 ENOG4108ZF3 Phosphatase BF36_1163 ENOG4105D9P serine threonine protein kinase BF36_1164 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BF36_1165 ENOG4105DJV ribulose-phosphate 3-epimerase BF36_1166 ENOG4105FJ0 thiamine BF36_1168 ENOG4108ZAA Alkaline-shock protein BF36_1169 ENOG4105DP4 dak2 domain fusion protein ylov BF36_117 ENOG4105WG9 Conserved Protein BF36_1170 ENOG4105CB5 ATP-dependent DNA helicase recG BF36_1173 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BF36_1174 ENOG4105CHR reductase BF36_1177 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BF36_1178 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BF36_1182 ENOG4105VB6 UPF0109 protein BF36_1187 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BF36_119 ENOG4107PBV potassium channel BF36_1190 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BF36_1191 ENOG4105C79 DNA protecting protein DprA BF36_1192 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BF36_1194 ENOG4108HE4 integrase family BF36_12 ENOG4105DZ1 carboxypeptidase BF36_1203 ENOG4105KNE Phosphatidate cytidylyltransferase BF36_1204 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BF36_1205 ENOG4105DZP Membrane-associated zinc metalloprotease BF36_1207 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF36_1209 ENOG4105CHV Transcription elongation factor NusA BF36_121 ENOG4105KT7 mgtC SapB transporter BF36_1210 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BF36_1211 ENOG4105VHM ribosomal protein BF36_1213 ENOG4105W7A Protein of unknown function (DUF503) BF36_1215 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BF36_1216 ENOG4105DTN riboflavin biosynthesis protein ribF BF36_1220 ENOG4105C1V Peptidase, M16 BF36_1222 ENOG4105E35 Dipicolinate synthase subunit A BF36_1223 ENOG4108S0H Dipicolinic acid synthetase, b subunit BF36_1224 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF36_1226 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF36_1228 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BF36_1230 ENOG4107QZI cell division protein FtsK BF36_1231 ENOG4105FDP GntR family transcriptional regulator BF36_1232 ENOG4105DIH basic membrane BF36_1233 ENOG4108JQ9 ABC transporter BF36_1234 ENOG4105UIB (ABC) transporter BF36_1238 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BF36_1239 ENOG4105XZV Protein of unknown function (DUF3243) BF36_1242 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BF36_1247 ENOG4105D48 metallophosphoesterase BF36_1248 ENOG4105MCT stage V sporulation protein S BF36_1249 ENOG4108IGT Dipeptidase BF36_1250 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BF36_1251 ENOG4105DQU oxidoreductase, subunit beta BF36_1257 ENOG4107QHE Choloylglycine hydrolase BF36_1259 ENOG410890F Dynamin family BF36_1260 ENOG4105E0M Sulfatase BF36_1261 ENOG4107R6R udp-galactopyranose mutase BF36_1262 ENOG4105F0V Cell wall hydrolase BF36_1266 ENOG4107YEI lmbE family BF36_1267 ENOG4107TTQ Alpha beta hydrolase fold BF36_1270 ENOG41067MG lrgb family BF36_1273 ENOG4105BZU Histidine kinase BF36_1274 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BF36_1280 ENOG4105D03 DNA-3-methyladenine glycosylase II BF36_1281 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF36_1283 ENOG4105CGK Exodeoxyribonuclease III BF36_1287 ENOG4105E0A ABC, transporter BF36_1288 ENOG4105NIV Esterase BF36_129 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BF36_1290 ENOG4105VPX protein, conserved in bacteria BF36_1291 ENOG410681U heavy metal transport detoxification protein BF36_1292 ENOG4105C59 p-type ATPase BF36_1293 ENOG4105K70 DNA-binding protein BF36_1294 ENOG4105TMB Formate nitrite transporter BF36_1298 ENOG4105C85 amino acid BF36_1301 ENOG4108SJC Membrane BF36_1302 ENOG4107QW4 alcohol dehydrogenase BF36_1303 ENOG4105E98 transcriptional regulator DeoR family BF36_1304 ENOG4105DE4 1-phosphofructokinase BF36_1305 ENOG4105DM4 PTS System BF36_1306 ENOG41069ER domain protein BF36_1312 ENOG4106F1P AAA ATPase, central domain protein BF36_1314 ENOG4105EN6 Membrane BF36_1315 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF36_1316 ENOG4105CXI aluminum resistance protein BF36_1317 ENOG4105KV4 Transcriptional regulator BF36_1318 ENOG4105C5F glutamine synthetase BF36_1339 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BF36_1377 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF36_1385 ENOG4105K7K Transcriptional regulator BF36_1389 ENOG4108SVB resolvase BF36_1391 ENOG4105CGH 5'-nucleotidase BF36_1393 ENOG4105D5T phosphonate abc transporter BF36_1396 ENOG4105D7V transposase BF36_1400 ENOG4105BZ1 (ABC) transporter BF36_1401 ENOG4105BZ1 (ABC) transporter BF36_1404 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF36_1409 ENOG41067MG lrgb family BF36_1411 ENOG4107RSM transcriptional regulator BF36_1413 ENOG4105CJ1 ABC, transporter BF36_1415 ENOG4105CH2 amidohydrolase BF36_1417 ENOG4107QIV Cytochrome c biogenesis protein BF36_1424 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BF36_1430 ENOG4108903 Formimidoylglutamase BF36_1431 ENOG4108VJ1 Transcriptional regulator (CarD family BF36_1432 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BF36_1433 ENOG4105CBC glutamate synthase BF36_1434 ENOG4105CK7 Sodium proline symporter BF36_1435 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BF36_1436 ENOG4105FBA Phospholipase Carboxylesterase BF36_1437 ENOG4105BZU Histidine kinase BF36_1439 ENOG4107AYK membrAne BF36_1448 ENOG4105CEY Amp-dependent synthetase and ligase BF36_1449 ENOG4107ZYJ bioY protein BF36_1450 ENOG4107F3J Amp-dependent synthetase and ligase BF36_1454 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF36_1456 ENOG4105E5W Transporter BF36_1462 ENOG4108I0Z Aconitate hydratase BF36_1463 ENOG4108JJA ABC, transporter BF36_1465 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF36_1466 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BF36_1472 ENOG4105W8X HesB YadR YfhF-family protein BF36_1473 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BF36_1474 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BF36_1476 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_1477 ENOG4105C0H protease BF36_1478 ENOG4105K4P CoA-binding domain protein BF36_1479 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF36_148 ENOG4105JVQ RNA Polymerase BF36_1481 ENOG4105D9R oxidoreductase BF36_1483 ENOG4105CIG ABC transporter BF36_1487 ENOG4105EMN RNA polymerase sigma factor BF36_1489 ENOG4108KGH TRANSCRIPTIONal BF36_1490 ENOG4107QJT sodium dicarboxylate symporter BF36_1493 ENOG4105DQ6 Transposase BF36_15 ENOG4105CHU acetyl-coa acetyltransferase BF36_150 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF36_1505 ENOG4105E1K spore germination protein BF36_1507 ENOG4108JB9 formate dehydrogenase BF36_1509 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BF36_1510 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF36_1512 ENOG4105TMB Formate nitrite transporter BF36_1513 ENOG4105D06 uba thif-type nad fad binding protein BF36_1514 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF36_1515 ENOG4108ZAF Molybdopterin BF36_1517 ENOG4105D1F ATP-binding protein BF36_1520 ENOG410696E Membrane BF36_1521 ENOG4105FR1 rard protein BF36_1523 ENOG4105EWU Squalene--hopene cyclase BF36_1525 ENOG4105CHR reductase BF36_1526 ENOG4105C26 Dehydrogenase BF36_1528 ENOG4108IA2 Sodium pantothenate symporter BF36_153 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BF36_1531 ENOG4106IQC argininosuccinate lyase BF36_1533 ENOG410904N short-chain dehydrogenase reductase BF36_1537 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BF36_1541 ENOG4105VEQ Cold shock protein BF36_1545 ENOG4108R1P BF36_1547 ENOG41073R8 VanW family BF36_1548 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF36_1550 ENOG4105KT7 mgtC SapB transporter BF36_1552 ENOG4105E39 Enoyl-CoA hydratase BF36_1553 ENOG4105K64 Glycosyl transferase, family 2 BF36_1555 ENOG4108UT6 Transferase hexapeptide repeat containing protein BF36_1559 ENOG4105CQB FAD linked oxidase domain protein BF36_1560 ENOG4105C09 Bile acid BF36_1567 ENOG4105CIS alcohol dehydrogenase BF36_1568 ENOG41082BM Transcriptional regulator, arsr family BF36_1572 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF36_1578 ENOG4108A04 Beta-lactamase BF36_1579 ENOG4105DPN Oligoendopeptidase f BF36_1580 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BF36_1581 ENOG4105E5K Alpha-amylase BF36_1583 ENOG4105C98 muts2 protein BF36_1587 ENOG4107V2S Transcriptional regulator BF36_1589 ENOG4107CUJ Protein of unknown function (DUF2690) BF36_1594 ENOG4107ZY0 Phenazine biosynthesis-like protein BF36_1595 ENOG4105NX3 Membrane BF36_1596 ENOG4105DQ5 transport system permease protein BF36_1597 ENOG4105EHG Permease protein BF36_1598 ENOG4108MES Periplasmic binding protein BF36_16 ENOG4105C1G acyl-Coa dehydrogenase BF36_160 ENOG4105VEQ Cold shock protein BF36_1601 ENOG4107R3E Citrate transporter BF36_1603 ENOG4108TN2 lmbE family BF36_1611 ENOG4105CIS alcohol dehydrogenase BF36_1618 ENOG4105H3G oxidoreductase BF36_162 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF36_1629 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BF36_163 ENOG4105E4F Isochorismate synthase BF36_1634 ENOG4105KAF membrAne BF36_164 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BF36_1643 ENOG4108ZJ4 polysaccharide deacetylase BF36_1645 ENOG4105KVH Transcriptional regulator BF36_1646 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BF36_1649 ENOG4105CHR reductase BF36_165 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BF36_1651 ENOG4105JAB phenazine biosynthesis protein, phzf family BF36_1659 ENOG4105KVH Transcriptional regulator BF36_166 ENOG4108IPT Naphthoate synthase BF36_1660 ENOG4105KVH Transcriptional regulator BF36_1661 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BF36_1662 ENOG4105D9R oxidoreductase BF36_1663 ENOG4108TZY GntR Family Transcriptional Regulator BF36_1670 ENOG4105C44 Serine transporter BF36_1677 ENOG4105D4Y metalloprotease BF36_1678 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BF36_168 ENOG4105DTQ mandelate racemase muconate lactonizing BF36_1681 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BF36_1683 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BF36_1686 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF36_1687 ENOG4105C6Z Gluconate BF36_1688 ENOG4105CMG Carbohydrate kinase BF36_1689 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BF36_1690 ENOG4105XDF Protein of unknown function (DUF1272) BF36_1691 ENOG4105DDN Pentapeptide repeat-containing protein BF36_1694 ENOG4105C37 (CBS) domain BF36_17 ENOG4108W8B Beta-lactamase domain protein BF36_1700 ENOG4105EV4 Multidrug resistance protein mdtH BF36_1702 ENOG4105DMQ Methyltransferase BF36_1708 ENOG4105C31 Tryptophanyl-tRNA synthetase BF36_1710 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF36_1712 ENOG4108UW5 maltose o-acetyltransferase BF36_1713 ENOG4106UW1 Major Facilitator superfamily BF36_1714 ENOG4105DKQ ROK family BF36_1715 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BF36_1727 ENOG4105CJ1 ABC, transporter BF36_1729 ENOG4108PSK reductase BF36_1733 ENOG4108RCM Nitroreductase BF36_1734 ENOG4105KVH Transcriptional regulator BF36_1737 ENOG4105CUT histidyl-tRNA synthetase BF36_1738 ENOG4108Z66 YbaK ebsC protein BF36_174 ENOG41069H0 dihydroorotase EC 3.5.2.3 BF36_1740 ENOG41067QW Transcriptional regulator BF36_1742 ENOG4108IND Tetr family transcriptional regulator BF36_1743 ENOG4105EQ0 Major Facilitator superfamily BF36_1750 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF36_1757 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF36_1759 ENOG4105CRW Short chain fatty acid transporter BF36_1761 ENOG4105KBX Transcriptional regulator, TetR family BF36_1762 ENOG4105KPY Small multidrug resistance protein BF36_1763 ENOG4105RXJ BF36_1765 ENOG41069JR BF36_1766 ENOG4105DA5 (ABC) transporter BF36_1770 ENOG4105CZM Major Facilitator BF36_1771 ENOG4107MII Sugar-specific transcriptional regulator TrmB BF36_1773 ENOG4108ISG Major Facilitator BF36_178 ENOG4105FDP GntR family transcriptional regulator BF36_1781 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF36_1785 ENOG410874W AraC family transcriptional regulator BF36_1786 ENOG41082W1 Cupin 2, conserved barrel domain protein BF36_179 ENOG4105C6Z Gluconate BF36_1790 ENOG4108JQ1 Dehydrogenase BF36_1793 ENOG4105DVH amino acid BF36_1795 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BF36_1798 ENOG4108JPW Aminotransferase BF36_1800 ENOG4105EJQ L-serine dehydratase BF36_1801 ENOG4105C44 Serine transporter BF36_1807 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF36_1814 ENOG4105TRI Hydrolase BF36_1820 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF36_1822 ENOG4106P55 Transcriptional regulator BF36_1824 ENOG4107QR9 Iron-sulfur cluster binding protein BF36_1825 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) BF36_1826 ENOG4105DJB Major Facilitator Superfamily BF36_1827 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF36_1829 ENOG4105BZU Histidine kinase BF36_1832 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BF36_1833 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BF36_1836 ENOG4105JQZ Methyltransferase BF36_1837 ENOG4105W1Y Transcriptional regulator BF36_1839 ENOG4105C88 aminopeptidase BF36_1842 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF36_1844 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BF36_1845 ENOG4108NNI Beta-lactamase domain-containing protein BF36_1850 ENOG4105K6H D-cysteine desulfhydrase BF36_1855 ENOG41062D9 Histidine kinase BF36_1856 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_1859 ENOG4105IIP Membrane BF36_1861 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF36_1862 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BF36_187 ENOG41086D8 Transcriptional regulator BF36_1875 ENOG4108YXU transcriptional regulator AsnC family BF36_1876 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BF36_1877 ENOG4108IG5 Transcriptional regulator BF36_1878 ENOG4107P5I polyketide synthase BF36_188 ENOG4105C19 ABC transporter BF36_1880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_1881 ENOG4105BZU Histidine kinase BF36_1885 ENOG41085FC arsR family transcriptional regulator BF36_1886 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BF36_1887 ENOG4105D6J arsenicaL-resistance protein BF36_1889 ENOG4105DBI uridine monophosphokinase BF36_1893 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BF36_1894 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BF36_1896 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BF36_1897 ENOG4108TWJ NADH dehydrogenase subunit 5 BF36_1900 ENOG4105CVP deoxyribo-dipyrimidine photolyase BF36_1901 ENOG4108606 TspO/MBR family BF36_1907 ENOG41090MY MarR family Transcriptional regulator BF36_191 ENOG4107ZTW SNARE associated Golgi BF36_1912 ENOG4105CHJ isochorismatase hydrolase BF36_1914 ENOG4105CH6 catalase BF36_1915 ENOG4105CGH 5'-nucleotidase BF36_1922 ENOG4105CSV Glutaminase BF36_1926 ENOG4108Q8B Spore germination protein BF36_1927 ENOG4108NHD germination protein BF36_1929 ENOG4105C6K Malic enzyme BF36_1931 ENOG4105II7 pyrroline-5-carboxylate reductase BF36_1933 ENOG4105CUB amino acid BF36_1934 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BF36_1935 ENOG4105YWU small acid-soluble spore protein BF36_1936 ENOG41075H3 AraC family transcriptional regulator BF36_1941 ENOG4105BZU Histidine kinase BF36_1943 ENOG4108B31 Spore germination protein BF36_1945 ENOG4108IMY Transcriptional regulator BF36_1946 ENOG4105HDK L-asparaginase BF36_1947 ENOG4108IJ0 Aspartate ammonia-lyase BF36_1949 ENOG4105E2A Dehydrogenase BF36_196 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BF36_1963 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BF36_1969 ENOG4105DWD nucleoside recognition domain protein BF36_197 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF36_1973 ENOG4105FDT acyl-CoA dehydrogenase BF36_1975 ENOG4108ZHR arsR family transcriptional regulator BF36_1976 ENOG4108ZRV stage ii sporulation protein p BF36_1977 ENOG4106N3A copper homeostasis protein cutc BF36_1979 ENOG4107258 Transcriptional regulator BF36_1980 ENOG4105P4J Allophanate hydrolase, subunit 1 BF36_1988 ENOG4107RF6 penicillin-binding protein BF36_1996 ENOG4105F1N DNA alkylation repair BF36_1998 ENOG4108IQI permease BF36_1999 ENOG4105KNA -acetyltransferase BF36_2000 ENOG410635A Membrane BF36_2013 ENOG4108XET gCN5-related N-acetyltransferase BF36_2019 ENOG4105C19 ABC transporter BF36_202 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_2021 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF36_2027 ENOG4105EFZ amidohydrolase BF36_2028 ENOG4105D2S major facilitator superfamily BF36_2029 ENOG4105G9B Transcriptional regulator BF36_203 ENOG4105BZU Histidine kinase BF36_2031 ENOG4105VZJ PTS System BF36_2034 ENOG4108QVC Component IIC BF36_2035 ENOG4105VCP PTS System BF36_2036 ENOG4105CS2 ec 3.2.1.21 BF36_2037 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF36_2038 ENOG4105E39 Enoyl-CoA hydratase BF36_2039 ENOG4105CHU acetyl-coa acetyltransferase BF36_2040 ENOG4105CEY Amp-dependent synthetase and ligase BF36_2044 ENOG4105ERH Fumarylacetoacetate hydrolase BF36_2048 ENOG4105FS7 Transcriptional regulator BF36_2049 ENOG4108TVJ Nitroreductase BF36_2058 ENOG4105C8Y Acetylornithine aminotransferase BF36_2060 ENOG4105CKK Glycosyl transferase, family 2 BF36_2064 ENOG4105CKK Glycosyl transferase, family 2 BF36_2069 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF36_2074 ENOG41068WN BF36_2076 ENOG4108WCX response regulator BF36_2078 ENOG41090T1 Membrane BF36_2081 ENOG4105VMP Transcriptional regulator BF36_2083 ENOG4105G6Z alkaline phosphatase BF36_2084 ENOG4105ECK Fatty Acid Desaturase BF36_2085 ENOG4105E0Y RtcB Protein BF36_2087 ENOG4107258 Transcriptional regulator BF36_2089 ENOG4105II7 pyrroline-5-carboxylate reductase BF36_2096 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BF36_210 ENOG41087YS Phage shock protein A BF36_2100 ENOG41061GT Aldolase BF36_2102 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BF36_2103 ENOG4105DKT Transcriptional regulator BF36_2105 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BF36_2106 ENOG4105F5R ABC transporter BF36_2107 ENOG4105D4B ABC, transporter BF36_2111 ENOG4108JUB Transcriptional regulator BF36_2112 ENOG4105J5T Amp-dependent synthetase and ligase BF36_2113 ENOG4105E39 Enoyl-CoA hydratase BF36_2114 ENOG4105CY2 Citrate transporter BF36_2116 ENOG41069ER domain protein BF36_2123 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BF36_2125 ENOG4105CIH Imidazole acetol-phosphate transaminase BF36_2129 ENOG41082JN Transcriptional regulator BF36_2130 ENOG4105EYF MMPL domain protein BF36_2132 ENOG4105C5H ABC transporter BF36_2133 ENOG4105E0M Sulfatase BF36_2134 ENOG4108ZCF integral membrane protein BF36_2136 ENOG4107VMI polysaccharide deacetylase BF36_2138 ENOG4107VC0 DNA alkylation repair enzyme BF36_2148 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BF36_2152 ENOG4105E09 nadh pyrophosphatase BF36_2157 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BF36_2158 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BF36_2159 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BF36_2161 ENOG4105C02 permease BF36_2168 ENOG4108ZMI UPF0477 protein BF36_2171 ENOG4105CHM Aminotransferase BF36_2178 ENOG41089UC methyltransferase, type 11 BF36_2181 ENOG4107BMA Transglycosylase associated protein BF36_2185 ENOG4106K7D Major facilitator family transporter BF36_2186 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF36_219 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF36_2194 ENOG4105EPR degv family BF36_2196 ENOG4105DPN Oligoendopeptidase f BF36_220 ENOG4105C4M (Ubiquinol oxidase) subunit I BF36_2202 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_2203 ENOG4105BZU Histidine kinase BF36_2204 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BF36_2213 ENOG4105DTQ mandelate racemase muconate lactonizing BF36_2216 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BF36_2217 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF36_222 ENOG4108V2W Carbonate dehydratase BF36_2220 ENOG4107T5V SNARE associated Golgi BF36_2226 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BF36_2228 ENOG41080HI glycine oxidase BF36_2229 ENOG4105CTU Proline racemase BF36_2230 ENOG4105CTU Proline racemase BF36_2231 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BF36_2232 ENOG4105C26 Dehydrogenase BF36_2233 ENOG4105BZG amino acid carrier protein BF36_2236 ENOG4108M1A Chitin-binding protein BF36_2245 ENOG4105C9U ATP-dependent DNA helicase RecQ BF36_2249 ENOG4105EEM helicase BF36_2253 ENOG4108Z7F N-acetyltransferase BF36_2259 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF36_2263 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF36_2267 ENOG41087PP glycosyltransferase MGT family BF36_2268 ENOG4108M1A Chitin-binding protein BF36_2269 ENOG41082BV acetyltransferase BF36_2270 ENOG4105E66 phosphoriboisomerase A BF36_2275 ENOG4108IJ7 Glycine betaine BF36_2276 ENOG4107SQ8 Glycine betaine BF36_2282 ENOG4105DBI uridine monophosphokinase BF36_2283 ENOG4105RHY Pfam:UPF0157 BF36_2284 ENOG4105E1F short-chain dehydrogenase reductase BF36_2286 ENOG4107RUY (E1 component), alpha subunit BF36_2288 ENOG4107QKR Dehydrogenase BF36_2293 ENOG4105E98 transcriptional regulator DeoR family BF36_2297 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BF36_2301 ENOG4107Z3H Transcriptional regulator, TetR family BF36_2308 ENOG4105MSI germination protein ypeb BF36_2321 ENOG4105FDR Membrane BF36_2323 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF36_2328 ENOG4108IUM Glycogen debranching enzyme BF36_233 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BF36_2331 ENOG4105DY8 decarboxylase BF36_2337 ENOG4107VFR oxidoreductase BF36_2345 ENOG4105PKS Excinuclease abc c subunit domain protein BF36_235 ENOG4105D2X ABC transporter substrate-binding protein BF36_2352 ENOG4105KWG Pfam:DUF1696 BF36_2353 ENOG4108NRW Phospholipase, patatin family BF36_2358 ENOG4108XI2 Domain of unknown function (DUF1963) BF36_2363 ENOG4108Z4K mutator MutT protein BF36_2364 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF36_2365 ENOG4105E09 nadh pyrophosphatase BF36_2367 ENOG4105FCD Major Facilitator BF36_2374 ENOG4107Y9U Membrane BF36_2378 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BF36_238 ENOG4107T7U Sulfatase BF36_2382 ENOG4107Y80 Major Facilitator superfamily BF36_239 ENOG4107S9D Alpha beta hydrolase BF36_2391 ENOG4105FQP Beta-lactamase BF36_2393 ENOG4105CJN penicillin-binding protein BF36_2394 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BF36_2395 ENOG4105CB2 alcohol dehydrogenase BF36_2398 ENOG4108HGU Histidine kinase BF36_240 ENOG4105BZU Histidine kinase BF36_2401 ENOG4108JJB ABC transporter BF36_2405 ENOG4107RF6 penicillin-binding protein BF36_2406 ENOG4105BZU Histidine kinase BF36_2407 ENOG410667J hydrolase BF36_241 ENOG4105BZU Histidine kinase BF36_242 ENOG4105EGD dinuclear metal center protein, YbgI family BF36_2423 ENOG4105ETU transcriptional activator (TenA BF36_2442 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BF36_2445 ENOG4105CPQ Dehydrogenase BF36_2455 ENOG4105CUV Homoserine Kinase BF36_2458 ENOG41089UC methyltransferase, type 11 BF36_2461 ENOG4108V4B ThiJ pfpI BF36_2465 ENOG4105FQP Beta-lactamase BF36_2468 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF36_2474 ENOG41075H3 AraC family transcriptional regulator BF36_2479 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BF36_2481 ENOG4105T9C HD domain BF36_2487 ENOG4105DBI uridine monophosphokinase BF36_2488 ENOG4105WCN acetyltransferase BF36_2490 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF36_2491 ENOG4107QX3 carboxylase BF36_2492 ENOG4105E39 Enoyl-CoA hydratase BF36_2493 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BF36_2494 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BF36_2495 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF36_2496 ENOG4105C1G acyl-Coa dehydrogenase BF36_2499 ENOG4107Z3H Transcriptional regulator, TetR family BF36_25 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF36_2501 ENOG4105CJ1 ABC, transporter BF36_2504 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BF36_2507 ENOG4105BZU Histidine kinase BF36_2508 ENOG4105C5H ABC transporter BF36_2509 ENOG41067SE Tetr family transcriptional regulator BF36_2512 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BF36_2515 ENOG4108VXD carboxy-peptidase BF36_2518 ENOG4105VZ8 Transcriptional regulator BF36_2521 ENOG4105CGH 5'-nucleotidase BF36_2524 ENOG4105DH8 myo-inositol catabolism BF36_2525 ENOG4105D2N Aldolase BF36_2530 ENOG4105CK5 oxidoreductase BF36_2531 ENOG4105IE8 Alpha-ketoglutarate permease BF36_2532 ENOG4105ETE Transcriptional regulator (LacI family BF36_2535 ENOG4107RF6 penicillin-binding protein BF36_2536 ENOG4107RF6 penicillin-binding protein BF36_254 ENOG4108RIR Molybdenum cofactor biosynthesis protein BF36_2542 ENOG4105CIN aminoacyl-histidine dipeptidase BF36_2550 ENOG41090HR transcriptional regulator BF36_2551 ENOG4107RA9 decarboxylase BF36_2552 ENOG4108I0C methyltransferase BF36_2554 ENOG41088CC tellurite resistance protein tehB BF36_2558 ENOG4108RZE Tetr family transcriptional regulator BF36_256 ENOG4105BZF Glycosyl transferase (Group 1 BF36_2560 ENOG4105C1J atp-dependent rna helicase BF36_2563 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF36_2568 ENOG4107STF Involved in phosphonate degradation (By similarity) BF36_257 ENOG4105YVM Phosphoesterase, PA-phosphatase related BF36_2570 ENOG4105RD7 BadF BadG BcrA BcrD BF36_2575 ENOG4105F32 YngK protein BF36_258 ENOG4108Z0R Transferase BF36_2580 ENOG4108KPJ rna polymerase sigma factor BF36_2583 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF36_259 ENOG4105E8V Alpha Beta Hydrolase Fold protein BF36_2590 ENOG4108JCI Transcriptional regulator BF36_2594 ENOG4105BZ1 (ABC) transporter BF36_2595 ENOG4105BZ1 (ABC) transporter BF36_2598 ENOG4108RPX mosc domain containing protein BF36_2599 ENOG4105DND Transcriptional regulator BF36_2602 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BF36_2603 ENOG4107V2S Transcriptional regulator BF36_2610 ENOG410667J hydrolase BF36_2614 ENOG4105VEQ Cold shock protein BF36_2616 ENOG41068WN BF36_2617 ENOG41089UC methyltransferase, type 11 BF36_2619 ENOG4105C1Q protoporphyrinogen oxidase BF36_2625 ENOG4105WCN acetyltransferase BF36_2629 ENOG4105EYF MMPL domain protein BF36_2631 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BF36_2634 ENOG4108Y4K DNA-binding transcriptional activator BF36_2636 ENOG41081I9 integral membrane protein BF36_2641 ENOG4108D32 Methyltransferase BF36_2646 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF36_2648 ENOG4105C19 ABC transporter BF36_2649 ENOG4105C22 threonyL-tRNA synthetase BF36_265 ENOG4105CIG ABC transporter BF36_2650 ENOG4105FE9 pseudouridine synthase BF36_2654 ENOG4105BZG amino acid carrier protein BF36_2658 ENOG4105K70 DNA-binding protein BF36_2661 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF36_2662 ENOG4105WQT MbtH domain protein BF36_2663 ENOG4105CEY Amp-dependent synthetase and ligase BF36_2664 ENOG4105WQI isochorismatase BF36_2665 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BF36_2666 ENOG4105E4F Isochorismate synthase BF36_2667 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BF36_2668 ENOG4105FCD Major Facilitator BF36_267 ENOG4105N5T Radical SAM Protein BF36_2695 ENOG4105VTR Integrase BF36_2696 ENOG4105EYH Exonuclease BF36_2697 ENOG4107RFY SbcCD D subunit BF36_2700 ENOG4105E39 Enoyl-CoA hydratase BF36_2701 ENOG4105N14 lysine exporter protein LysE YggA BF36_2703 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF36_2704 ENOG4105C1G acyl-Coa dehydrogenase BF36_2705 ENOG4105CR4 methylisocitrate lyase BF36_2706 ENOG4105DXD 2-methylcitrate dehydratase BF36_2708 ENOG4105W8X HesB YadR YfhF-family protein BF36_2709 ENOG4105CZM Major Facilitator BF36_2710 ENOG4105BZ4 penicillin-binding protein BF36_2718 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF36_2729 ENOG4105SZ6 Thioredoxin BF36_2730 ENOG410841Q phosphoesterase PA-phosphatase related protein BF36_2732 ENOG4108N23 SpoOM-related protein BF36_2740 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BF36_2741 ENOG4108JUB Transcriptional regulator BF36_2742 ENOG4108TSC N-acetyltransferase BF36_2743 ENOG4107S4Y M20 DapE family protein YgeY BF36_2746 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF36_2751 ENOG4105C37 (CBS) domain BF36_2758 ENOG4105E90 ABC transporter BF36_2759 ENOG4108IJ8 ABC transporter BF36_276 ENOG4105NCW Trka-c domain protein BF36_277 ENOG4107S91 Sodium hydrogen exchanger BF36_2771 ENOG4106KNT transcriptional regulator BF36_2773 ENOG4105WH1 Two component transcriptional regulator luxr family BF36_2774 ENOG4105BZU Histidine kinase BF36_2775 ENOG4105D8X mechanosensitive ion channel BF36_2776 ENOG4107Y70 Heat shock protein BF36_278 ENOG410605W Major Facilitator BF36_2782 ENOG4105F0I Aminotransferase BF36_2783 ENOG4108MES Periplasmic binding protein BF36_2787 ENOG4105CAQ asparagine synthetase BF36_2788 ENOG4107Y70 Heat shock protein BF36_2789 ENOG4108KF3 Electron transport protein SCO1 SenC BF36_2790 ENOG4105E8R UPF0173 metal-dependent hydrolase BF36_2791 ENOG4108RCR degv family BF36_2793 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BF36_2795 ENOG4108UT2 hemolysin iii BF36_2796 ENOG4105E9Q Acyl-transferase BF36_2798 ENOG4107RVG penicillin-binding protein BF36_2802 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BF36_2806 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BF36_2811 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BF36_2812 ENOG4105KD7 acetyltransferase BF36_2815 ENOG4105C0A alcohol dehydrogenase BF36_2816 ENOG4105CY2 Citrate transporter BF36_2817 ENOG4107XGZ Hydrolase BF36_2821 ENOG4105C8J )-transporter BF36_2824 ENOG41062D9 Histidine kinase BF36_2825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_2826 ENOG4107QPK )-transporter BF36_2827 ENOG4105BZW Glycerate kinase BF36_284 ENOG4108B31 Spore germination protein BF36_2843 ENOG4106ANW SMI1_KNR4 BF36_2844 ENOG4106BHF BF36_2849 ENOG4105EC2 ftsk spoIIIe BF36_2853 ENOG4105C5S asparaginyl-tRNA synthetase BF36_2854 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF36_2863 ENOG4107YX5 Pfam:DUF548 BF36_2867 ENOG4108UUM single-stranded DNA-binding protein BF36_287 ENOG4105DWV Homoserine O-trans-acetylase BF36_2870 ENOG4105C5H ABC transporter BF36_2874 ENOG4105MCT stage V sporulation protein S BF36_2881 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BF36_2882 ENOG4108IFG nitrite reductase, (NAD(P)H) BF36_2883 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BF36_2884 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF36_2885 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF36_2886 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF36_289 ENOG41085GJ domain protein BF36_2890 ENOG4108ZAF Molybdopterin BF36_2891 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF36_2892 ENOG4105D06 uba thif-type nad fad binding protein BF36_2893 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF36_2894 ENOG4107V6Q Cyclic nucleotide-binding domain BF36_2896 ENOG4105CZV ABC transporter BF36_2899 ENOG4105R3A Nitrate reductase BF36_2900 ENOG4108IUE nitrate reductase beta subunit BF36_2902 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BF36_2905 ENOG4108V06 Glutathione peroxidase BF36_2909 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BF36_2911 ENOG4105EMN RNA polymerase sigma factor BF36_2912 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BF36_2914 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BF36_2915 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BF36_2919 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BF36_2924 ENOG4105KBJ sporulation protein ytfj BF36_2929 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF36_293 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BF36_2935 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF36_2936 ENOG4108JYZ YitT family BF36_2939 ENOG4107RBS Methyltransferase BF36_294 ENOG4105D06 uba thif-type nad fad binding protein BF36_2940 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF36_2942 ENOG4108X4Q Hydrolase BF36_2947 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF36_2949 ENOG4108VXD carboxy-peptidase BF36_2951 ENOG4108ZRV stage ii sporulation protein p BF36_2955 ENOG4108Z7R Chaperone CsaA BF36_2959 ENOG4105C37 (CBS) domain BF36_296 ENOG4105CVM Molybdenum cofactor synthesis domain protein BF36_2960 ENOG4105SXS Protein of unknown function (DUF456) BF36_2964 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF36_2965 ENOG4108S4H thioesterase Superfamily protein BF36_2967 ENOG4108PJD permease BF36_297 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BF36_2970 ENOG4107T5V SNARE associated Golgi BF36_2974 ENOG4105CVJ phosphoglycerate mutase BF36_2979 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BF36_298 ENOG4108ZAF Molybdopterin BF36_2981 ENOG4105K4T epimerase BF36_2983 ENOG4105DSE periplasmic solute binding protein BF36_2995 ENOG4105CKI cobalamin synthesis protein BF36_2996 ENOG4107QM2 Aldo Keto reductase BF36_3 ENOG4107R7I amino acid BF36_3000 ENOG4105DEN Luciferase family BF36_3003 ENOG4108WPJ Ferritin-like domain BF36_3004 ENOG4108K88 Membrane BF36_3007 ENOG4105C8Q Methyl-accepting chemotaxis BF36_3012 ENOG4107XZQ multidrug resistance protein BF36_3013 ENOG4107SET aldo keto reductase BF36_3014 ENOG4105YVS arsR family transcriptional regulator BF36_3018 ENOG4105KRN Transcriptional regulator, abrb family BF36_302 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BF36_3028 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BF36_303 ENOG4108VJ1 Transcriptional regulator (CarD family BF36_3030 ENOG4105YWU small acid-soluble spore protein BF36_3031 ENOG4108WBH protein TIM barrel BF36_3034 ENOG4105CEY Amp-dependent synthetase and ligase BF36_3035 ENOG4105DUU IucA IucC family protein BF36_3037 ENOG4105VRR gCN5-related N-acetyltransferase BF36_3038 ENOG4105KT7 mgtC SapB transporter BF36_3040 ENOG4107VMI polysaccharide deacetylase BF36_3041 ENOG4105BZU Histidine kinase BF36_3042 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF36_3044 ENOG4108KGH TRANSCRIPTIONal BF36_3049 ENOG4105D6E homoserine dehydrogenase BF36_3052 ENOG4106AKJ BF36_3053 ENOG4108ZJ4 polysaccharide deacetylase BF36_3054 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BF36_3057 ENOG4105BZU Histidine kinase BF36_3058 ENOG4105EFI regulatoR BF36_3059 ENOG4105BZ1 (ABC) transporter BF36_3064 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF36_3067 ENOG4108JJ8 (ABC) transporter BF36_3068 ENOG4108JJ9 ABC, transporter BF36_3069 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BF36_3070 ENOG4105C4M (Ubiquinol oxidase) subunit I BF36_3074 ENOG4105MDS 4-oxalocrotonate tautomerase BF36_3076 ENOG4105SKE transcriptional Regulator LysR family BF36_3078 ENOG4105C32 Amino acid ABC transporter (Permease) BF36_3079 ENOG4108IV0 ABC, transporter BF36_3080 ENOG4105C0Z ABC transporter BF36_3082 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF36_3083 ENOG4108Z7G MaoC domain protein dehydratase BF36_3087 ENOG4105CKI cobalamin synthesis protein BF36_3089 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BF36_3090 ENOG4106F5Q Membrane BF36_3091 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BF36_3094 ENOG4108TVJ Nitroreductase BF36_3095 ENOG4107ZXU DSBA oxidoreductase BF36_3096 ENOG4108Z40 Transcriptional regulator BF36_3097 ENOG4105GZI Transcriptional regulator BF36_3098 ENOG4107RT3 EamA-like transporter family BF36_3099 ENOG4105KTB nuclear export factor GLE1 BF36_310 ENOG4105CBX hi0933 family BF36_3100 ENOG4108T5E Copper resistance protein BF36_3109 ENOG4107R16 Multicopper oxidase BF36_3110 ENOG4107RAQ aminopeptidase BF36_3116 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BF36_3117 ENOG4105D9N nucleoside BF36_3119 ENOG4107RHR regulatoR BF36_3124 ENOG4105C0X amino acid BF36_3126 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BF36_3128 ENOG4105C72 UPF0176 protein BF36_3129 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BF36_313 ENOG4105YW5 deoR family transcriptional regulator BF36_3133 ENOG41068WN BF36_314 ENOG4107QSE Dipeptidase BF36_3143 ENOG4105CYC Transferase BF36_3144 ENOG4105DY9 regulatoR BF36_3146 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BF36_3147 ENOG4105C6X Major Facilitator BF36_3152 ENOG4105C7B Threonine dehydratase BF36_3154 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BF36_3155 ENOG4108ZP8 Acetolactate synthase small subunit BF36_3156 ENOG4105C7K acetolactate synthase BF36_3157 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF36_3158 ENOG4105CHR reductase BF36_3159 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BF36_316 ENOG4108IUM Glycogen debranching enzyme BF36_3162 ENOG4105H67 Protein of unknown function (DUF421) BF36_3163 ENOG4105X5K response regulator receiver protein BF36_3165 ENOG4105C8J )-transporter BF36_3169 ENOG4105C6T cysteine synthase BF36_317 ENOG4108V15 phosphotransferase enzyme family BF36_3170 ENOG4105EU0 Major facilitator Superfamily BF36_3172 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BF36_3175 ENOG4105DXI Major Facilitator superfamily BF36_3177 ENOG4105U3E Transcriptional regulator BF36_3178 ENOG4105CSR polyphosphate kinase 2 BF36_3186 ENOG4105FVX BF36_3198 ENOG4105C6K Malic enzyme BF36_3199 ENOG4108IJ0 Aspartate ammonia-lyase BF36_320 ENOG4105C8F Beta-lactamase domain protein BF36_3201 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BF36_3205 ENOG4105CJ1 ABC, transporter BF36_3212 ENOG4106BRA Membrane BF36_3218 ENOG4107QIV Cytochrome c biogenesis protein BF36_3222 ENOG4105EC3 peptidase S51, dipeptidase E BF36_3223 ENOG4107QJQ Mate efflux family protein BF36_3227 ENOG4105C9Q fumarate hydratase class II BF36_3229 ENOG4105VUF Transcriptional regulator BF36_3230 ENOG4105DFD Na H antiporter BF36_3233 ENOG4108PJD permease BF36_3234 ENOG4105CKI cobalamin synthesis protein BF36_3235 ENOG4108UZ3 Transporter BF36_3236 ENOG4105DRR Transcriptional regulator, GntR family BF36_3238 ENOG4105PGM cation diffusion facilitator family transporter BF36_3242 ENOG4105CAQ asparagine synthetase BF36_3244 ENOG4105K56 Transcriptional regulator BF36_3248 ENOG4105CVJ phosphoglycerate mutase BF36_3255 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BF36_3256 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BF36_3258 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF36_3259 ENOG4105DUM transcriptional regulator, lysR family BF36_326 ENOG4108VDD TRNA binding domain protein BF36_3264 ENOG4105KAC Antibiotic biosynthesis monooxygenase BF36_3271 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BF36_3272 ENOG4105KTQ flagellar basal-body rod protein BF36_3273 ENOG4105FZW flagellar biosynthesis regulator FlhF BF36_3274 ENOG4105D7B Flagellar biosynthesis protein flha BF36_3275 ENOG4105D00 flagellar biosynthetic protein flhB BF36_3277 ENOG4105VS8 Flagellar biosynthetic protein fliq BF36_3278 ENOG4105CN7 Flagellar biosynthetic protein FliP BF36_3280 ENOG4105DD5 Flagellar motor switch protein BF36_3281 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF36_3283 ENOG4105E4C Lytic transglycosylase catalytic BF36_3284 ENOG4105I03 Flagellin BF36_3290 ENOG4107R88 Chemotaxis protein (CheV) BF36_3293 ENOG4105BZE flagellar hook protein, FlgE BF36_3299 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BF36_33 ENOG41080E8 Transcriptional regulator, Spx MgsR family BF36_3302 ENOG41075Z6 flagellar hook-basal body complex protein fliE BF36_3303 ENOG4108ZC9 flagellar basal-body rod protein flgc BF36_3304 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BF36_3307 ENOG4107TPX flagellar hook-associated BF36_3308 ENOG4105DTJ flagellar hook-associated protein BF36_3309 ENOG4105E1Q flagellar hook-associated protein BF36_3313 ENOG4105BZU Histidine kinase BF36_3316 ENOG4105DD5 Flagellar motor switch protein BF36_3317 ENOG4105CBS Chea signal transduction histidine kinase BF36_3318 ENOG4107YTP response regulator receiver protein BF36_3319 ENOG4105ER2 Ompa motb domain protein BF36_332 ENOG4105K7K Transcriptional regulator BF36_3320 ENOG4107R0U MotA TolQ exbB proton channel BF36_3322 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BF36_3334 ENOG41080C8 DUF218 domain BF36_3335 ENOG4105H67 Protein of unknown function (DUF421) BF36_3337 ENOG4108Z5V transcriptional regulator, merr family BF36_3338 ENOG4105CN5 Metallo-Beta-Lactamase BF36_3339 ENOG4107RWR Sodium hydrogen exchanger BF36_3341 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF36_3354 ENOG41081VK Ribonuclease BF36_3358 ENOG4108SZE gCN5-related N-acetyltransferase BF36_3361 ENOG4105CPK Glycosyl transferase (Group 1 BF36_3373 ENOG4106032 Glutathionylspermidine synthase BF36_3376 ENOG4105KHC sulfurtransferase BF36_3378 ENOG4108W0I acetyltransferase BF36_338 ENOG4105C88 aminopeptidase BF36_3380 ENOG410890F Dynamin family BF36_3382 ENOG4105DHF Membrane BF36_3383 ENOG4105C2W permease BF36_3385 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF36_3388 ENOG4105CTD carboxy-peptidase BF36_3389 ENOG4105DVT helicase BF36_3391 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BF36_3402 ENOG4105BZ4 penicillin-binding protein BF36_3404 ENOG4105CSM endonuclease III BF36_3408 ENOG4105YAC BF36_3409 ENOG4105DVT helicase BF36_3416 ENOG4105CPK Glycosyl transferase (Group 1 BF36_3417 ENOG4105FJR Lmbe family BF36_342 ENOG4105ETE Transcriptional regulator (LacI family BF36_3420 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BF36_3421 ENOG4108JYZ YitT family BF36_3427 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit BF36_3428 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BF36_3429 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BF36_3432 ENOG41068YB TPR repeat-containing protein BF36_3433 ENOG4105CIH Imidazole acetol-phosphate transaminase BF36_3437 ENOG4105EAH synthase BF36_3439 ENOG4105XXQ heptaprenyl diphosphate synthase component I BF36_3442 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BF36_3448 ENOG41065D1 BF36_3449 ENOG4105S2F BF36_3456 ENOG4107RB3 L-asparaginase BF36_3457 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BF36_3462 ENOG4108S6Z Negative regulator of genetic competence BF36_3463 ENOG4107X2D transcriptional regulator, merr family BF36_3464 ENOG4107RGJ metallophosphoesterase BF36_3466 ENOG4105I7S Abortive infection protein BF36_3467 ENOG4105C9U ATP-dependent DNA helicase RecQ BF36_3470 ENOG4108SAX Membrane BF36_3472 ENOG41063SB peptidase BF36_3473 ENOG4108WBT adenosyltransferase BF36_3474 ENOG4105BZU Histidine kinase BF36_3475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_3476 ENOG4105CRE cytochrome C BF36_3477 ENOG4107TWT Cytochrome c biogenesis protein BF36_3479 ENOG4105FE9 pseudouridine synthase BF36_348 ENOG4105EP9 oxidoreductase BF36_3481 ENOG4108JIC nucleoside recognition domain protein BF36_3482 ENOG4105DZ1 carboxypeptidase BF36_3483 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF36_349 ENOG4107SNB ankyrin repeat protein YahD BF36_3490 ENOG4105BZU Histidine kinase BF36_3493 ENOG4105I3N Conserved Protein BF36_3494 ENOG4105BZU Histidine kinase BF36_3497 ENOG4105BZ4 penicillin-binding protein BF36_3498 ENOG4107GRR phosphate transport regulator BF36_3499 ENOG4105CJ3 phosphate transporter BF36_3508 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BF36_351 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF36_3512 ENOG4105WH1 Two component transcriptional regulator luxr family BF36_3513 ENOG4105ENE Histidine kinase BF36_3517 ENOG4105DFD Na H antiporter BF36_3521 ENOG4105C8J )-transporter BF36_3522 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BF36_3523 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BF36_3524 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BF36_3526 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BF36_3527 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BF36_353 ENOG4106HB6 Alpha beta hydrolase BF36_3531 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BF36_3533 ENOG4105E0M Sulfatase BF36_3534 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF36_3537 ENOG4107RVV histidinol phosphate phosphatase, hisj family BF36_354 ENOG4105DGU Histone deacetylase BF36_355 ENOG4105W87 Cbs domain BF36_3552 ENOG4108ZP8 Acetolactate synthase small subunit BF36_3553 ENOG4105C7K acetolactate synthase BF36_3554 ENOG4105CM2 brancheD-chain amino acid aminotransferase BF36_3558 ENOG4105KBJ sporulation protein ytfj BF36_3559 ENOG41063Y9 BF36_356 ENOG4105F1V Acetoin utilization protein BF36_3560 ENOG4105CZN Potassium uptake protein BF36_3566 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BF36_3575 ENOG4105NQC Flavodoxin BF36_3580 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF36_3582 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BF36_3583 ENOG4105EA8 2-Nitropropane dioxygenase BF36_3584 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BF36_359 ENOG4105EMN RNA polymerase sigma factor BF36_3592 ENOG4105CJ1 ABC, transporter BF36_3594 ENOG4105CZV ABC transporter BF36_3595 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF36_3596 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF36_3597 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF36_3599 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BF36_3600 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BF36_3608 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BF36_3609 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BF36_361 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF36_3611 ENOG4105BZU Histidine kinase BF36_3613 ENOG4106DF1 BF36_3615 ENOG41090MY MarR family Transcriptional regulator BF36_3616 ENOG4105BZU Histidine kinase BF36_3618 ENOG4105PXI polysaccharide deacetylase BF36_3620 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BF36_3623 ENOG4105E98 transcriptional regulator DeoR family BF36_3628 ENOG4107RCV ABC transporter, permease BF36_3629 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF36_3630 ENOG4105C4Y ABC transporter BF36_3634 ENOG4105MWK D-amino acid dehydrogenase, small subunit BF36_3636 ENOG4105CHR reductase BF36_3640 ENOG4108Z7G MaoC domain protein dehydratase BF36_3641 ENOG410681C small acid-soluble spore protein BF36_3642 ENOG4105CZN Potassium uptake protein BF36_3643 ENOG4107TS3 membrane protein, TerC BF36_3644 ENOG4108QTI )-transporter BF36_3646 ENOG4106A3R peptidase BF36_365 ENOG4105C28 cystathionine BF36_3650 ENOG4105JXH GntR family transcriptional regulator BF36_3651 ENOG4105BZU Histidine kinase BF36_3652 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_3655 ENOG4105CQB FAD linked oxidase domain protein BF36_3656 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BF36_3657 ENOG4105K4I Scp-like extracellular BF36_3659 ENOG4108YBP pseudouridine synthase BF36_3661 ENOG4105EYF MMPL domain protein BF36_3663 ENOG4107RUE extracellular solute-binding protein family 1 BF36_3664 ENOG4105D38 putrescine abc transporter BF36_3665 ENOG4105F38 ABC transporter, permease BF36_3667 ENOG4105C26 Dehydrogenase BF36_367 ENOG4105U5Y Transcriptional regulator BF36_3673 ENOG4105VFR signal peptidase BF36_3674 ENOG4105DZ1 carboxypeptidase BF36_3676 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BF36_3689 ENOG4105VZ8 Transcriptional regulator BF36_369 ENOG4106KR7 LysR family Transcriptional regulator BF36_3691 ENOG4105C7S Dehydrogenase BF36_3709 ENOG4105DDQ anthranilate synthase BF36_3710 ENOG4105CRQ synthase (Component I) BF36_3711 ENOG4105CK7 Sodium proline symporter BF36_3725 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BF36_3727 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BF36_3728 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BF36_3733 ENOG4107TVC Glycosyl transferase, family 2 BF36_3737 ENOG4105K64 Glycosyl transferase, family 2 BF36_374 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BF36_3741 ENOG4105EMS pseudouridine synthase BF36_3742 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BF36_3745 ENOG4105MIX Adenylate cyclase BF36_3746 ENOG4108Z18 K06886 hemoglobin BF36_3749 ENOG4105DPN Oligoendopeptidase f BF36_3751 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF36_3753 ENOG4108ZCF integral membrane protein BF36_3757 ENOG4105UQX Mate efflux family protein BF36_3758 ENOG4108JQ7 (ABC) transporter BF36_376 ENOG4105EFZ amidohydrolase BF36_3760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF36_3761 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF36_3764 ENOG4105C31 Tryptophanyl-tRNA synthetase BF36_3767 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BF36_3768 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BF36_3773 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BF36_3775 ENOG4108KP7 hydrolase BF36_3777 ENOG41073B9 BF36_3778 ENOG4107AYK membrAne BF36_3780 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF36_3782 ENOG4105QNR S1 RNA binding domain protein BF36_3786 ENOG4105BZU Histidine kinase BF36_3787 ENOG4105CH6 catalase BF36_3788 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BF36_3789 ENOG4105CAQ asparagine synthetase BF36_379 ENOG4105KBJ sporulation protein ytfj BF36_3794 ENOG4105ERH Fumarylacetoacetate hydrolase BF36_380 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BF36_3808 ENOG4105XVF Competence transcription factor BF36_3812 ENOG4105VEQ Cold shock protein BF36_3815 ENOG4107QP3 malate synthase g BF36_3816 ENOG4105ZU5 s-layer protein BF36_3820 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BF36_3825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF36_3828 ENOG41086D8 Transcriptional regulator BF36_3829 ENOG4108AEY RNA polymerase sigma factor BF36_3831 ENOG4107TVP HD domain protein BF36_3832 ENOG4107RN3 metallophosphoesterase BF36_3833 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BF36_3837 ENOG4105CEY Amp-dependent synthetase and ligase BF36_3839 ENOG4105DF9 Lipoate-protein, ligase BF36_3840 ENOG4108RQ5 Beta-lactamase domain-containing protein BF36_3841 ENOG4106AXD BF36_3843 ENOG4108MK9 spermidine N(1)-acetyltransferase BF36_3847 ENOG4105ECB domain protein BF36_3855 ENOG4105C1Q protoporphyrinogen oxidase BF36_3858 ENOG4105BZ4 penicillin-binding protein BF36_3859 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BF36_386 ENOG4108JYZ YitT family BF36_3860 ENOG4105CKV Membrane BF36_3861 ENOG410905X membrane-flanked domain protein BF36_3869 ENOG4105CKV Membrane BF36_3870 ENOG410905X membrane-flanked domain protein BF36_3877 ENOG4105K59 histidine triad (HIT) protein BF36_3882 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BF36_3883 ENOG4105EEM helicase BF36_3885 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF36_3886 ENOG4105C57 major facilitator superfamily BF36_3889 ENOG4105CNI cell division protein FtsW BF36_3891 ENOG4105EMN RNA polymerase sigma factor BF36_3894 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BF36_3897 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF36_39 ENOG4108UMI ABC transporter, permease BF36_3901 ENOG4108MUZ hydrolase BF36_3912 ENOG4106D4I domain protein BF36_3913 ENOG4107VRP DNA repair exonuclease BF36_3920 ENOG4105K8R UPF0145 protein BF36_3925 ENOG4105BZU Histidine kinase BF36_3926 ENOG4105BZU Histidine kinase BF36_3927 ENOG4108MJI response regulator BF36_3929 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF36_3931 ENOG4105WN5 stage II sporulation protein BF36_3944 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BF36_3946 ENOG410847I Transcriptional regulator, BadM Rrf2 family BF36_3948 ENOG4105CMT Dihydroxyacetone kinase BF36_395 ENOG4107YZX Universal stress protein BF36_3950 ENOG4105CMT Dihydroxyacetone kinase BF36_3954 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BF36_3957 ENOG4108IG5 Transcriptional regulator BF36_3958 ENOG4107P5I polyketide synthase BF36_3968 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF36_3976 ENOG4105CDU Replicative dna helicase BF36_399 ENOG4105VZ8 Transcriptional regulator BF36_3993 ENOG4108MRH transcriptional regulatory protein BF36_3995 ENOG4105CSH Transporter BF36_3998 ENOG4108JQ7 (ABC) transporter BF36_4 ENOG4108SUT Major Facilitator Superfamily BF36_40 ENOG4105D01 (LipO)protein BF36_4000 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF36_401 ENOG41082W1 Cupin 2, conserved barrel domain protein BF36_4014 ENOG4105DER m42 family BF36_4021 ENOG4105CGU Enoyl-CoA hydratase BF36_4023 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BF36_4025 ENOG4106AKK s-layer domain-containing protein BF36_4033 ENOG4105CHH sulfate transporter BF36_4036 ENOG4105D4P Coproporphyrinogen iii oxidase BF36_4037 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BF36_4041 ENOG4107FQX Alpha-acetolactate decarboxylase BF36_4048 ENOG410839P BF36_4051 ENOG4105CDA abc transporter atp-binding protein BF36_4052 ENOG4105DRP amino acid AbC transporter BF36_4054 ENOG4105BZ1 (ABC) transporter BF36_4055 ENOG4105BZ1 (ABC) transporter BF36_4056 ENOG4105C26 Dehydrogenase BF36_4058 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BF36_4059 ENOG4105D5Q Arginine ornithine antiporter BF36_4061 ENOG4105CH6 catalase BF36_4062 ENOG4107RKG DJ-1/PfpI family BF36_4064 ENOG4105E5W Transporter BF36_4065 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BF36_4067 ENOG4105NF4 modulator of drug activity BF36_4072 ENOG4105KPY Small multidrug resistance protein BF36_4073 ENOG4105KPY Small multidrug resistance protein BF36_4075 ENOG4108YXU transcriptional regulator AsnC family BF36_4083 ENOG4106KNT transcriptional regulator BF36_4085 ENOG4107RWR Sodium hydrogen exchanger BF36_4086 ENOG4105CUB amino acid BF36_4093 ENOG4107T5V SNARE associated Golgi BF36_41 ENOG4105D01 (LipO)protein BF36_410 ENOG4105DC7 peptidase M24 BF36_4100 ENOG4105WEF catalase BF36_4106 ENOG4105C19 ABC transporter BF36_4107 ENOG4107RBB ABC transporter, permease BF36_4108 ENOG41069ER domain protein BF36_4112 ENOG4105VZJ PTS System BF36_4113 ENOG4105VCP PTS System BF36_4114 ENOG4105EMD TRANSCRIPTIONal BF36_4119 ENOG4108KGH TRANSCRIPTIONal BF36_4121 ENOG41087NI Sulfite exporter TauE/SafE BF36_4122 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BF36_4124 ENOG4105VFE sira family BF36_4126 ENOG4105VFE sira family BF36_4127 ENOG4107TPS domain protein BF36_4128 ENOG4105VFE sira family BF36_4129 ENOG4105XTG Pfam:DUF156 BF36_4130 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BF36_4132 ENOG4108TCS Glutamyl endopeptidase BF36_4133 ENOG4105ED1 spovr family BF36_4134 ENOG4107Y03 Nitroreductase BF36_4138 ENOG4108B31 Spore germination protein BF36_4145 ENOG4105C5Y PTS System BF36_4149 ENOG4108PXI ErfK YbiS YcfS YnhG BF36_4151 ENOG4105C7N Xanthine uracil vitamin C permease BF36_4156 ENOG4108INS Transcriptional regulator BF36_4165 ENOG4105DWF phosphomethylpyrimidine kinase BF36_4166 ENOG4105D06 uba thif-type nad fad binding protein BF36_4169 ENOG41080HI glycine oxidase BF36_4170 ENOG4108VEU Thiamine monophosphate synthase BF36_4172 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF36_4174 ENOG4105ETU transcriptional activator (TenA BF36_4178 ENOG41080XQ Signal transduction protein with cbs domains BF36_418 ENOG4105SFS phosphoesterase RecJ domain protein BF36_42 ENOG4105C3K feS assembly ATPase SufC BF36_420 ENOG4105VV2 BF36_4203 ENOG4105E2Z phosphate ABC transporter (Permease BF36_4204 ENOG4105C8U phosphate abc transporter BF36_4205 ENOG4105CVA phosphate BF36_4206 ENOG4105CE1 Ferrous iron transport protein b BF36_4207 ENOG4105CE1 Ferrous iron transport protein b BF36_4208 ENOG4105CE1 Ferrous iron transport protein b BF36_4209 ENOG4108NHD germination protein BF36_421 ENOG4105C0B DNA polymerase III (alpha subunit) BF36_4212 ENOG4105E1V na solute symporter BF36_4213 ENOG4106CAD Protein of unknown function (DUF3311) BF36_4216 ENOG4105E2S oxidase) subunit II BF36_4217 ENOG4105BZ9 Cytochrome C oxidase, subunit I BF36_422 ENOG4105C6K Malic enzyme BF36_4222 ENOG4105MA6 gCN5-related N-acetyltransferase BF36_4225 ENOG4105C7N Xanthine uracil vitamin C permease BF36_4226 ENOG4105C85 amino acid BF36_423 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BF36_4230 ENOG4105DUX Transporter BF36_4232 ENOG4107D63 BF36_4233 ENOG4105VZ8 Transcriptional regulator BF36_4234 ENOG41069ER domain protein BF36_4235 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF36_4248 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BF36_4249 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BF36_4250 ENOG4105CNN ABC, transporter BF36_4251 ENOG4105C2J ABC transporter BF36_4253 ENOG4108RVA ribokinase BF36_4254 ENOG4105ETE Transcriptional regulator (LacI family BF36_4255 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF36_4256 ENOG41067TZ transcriptional regulator, MarR family BF36_4257 ENOG4105CXY transporter BF36_4259 ENOG4108JQ7 (ABC) transporter BF36_4260 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF36_4264 ENOG41068KF Universal stress protein BF36_4265 ENOG4105CHH sulfate transporter BF36_4268 ENOG4105BZU Histidine kinase BF36_4269 ENOG4105NAE bifunctional deaminase-reductase domain protein BF36_4270 ENOG4105D29 Helix-turn-helix type 11 domain protein BF36_4274 ENOG4105GFR rna polymerase sigma factor BF36_4277 ENOG4108IQI permease BF36_4278 ENOG4105DRP amino acid AbC transporter BF36_4279 ENOG4105EAD ABC transporter BF36_428 ENOG4105FS0 cytoplasmic membrane protein BF36_4280 ENOG4105CT1 (ABC) transporter BF36_4281 ENOG4105CDA abc transporter atp-binding protein BF36_4282 ENOG4105BZG amino acid carrier protein BF36_4283 ENOG4105CRN Aminoglycoside phosphotransferase BF36_4285 ENOG4105E1K spore germination protein BF36_4288 ENOG4105CG3 alpha amylase, catalytic region BF36_4289 ENOG4105C5Y PTS System BF36_429 ENOG4108REF Sporulation integral membrane protein ytvi BF36_4290 ENOG4107414 GntR family transcriptional regulator BF36_4291 ENOG4105D5Q Arginine ornithine antiporter BF36_4292 ENOG4105BZU Histidine kinase BF36_4295 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BF36_4296 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BF36_4297 ENOG4107T89 von Willebrand factor, type A BF36_4299 ENOG4105EXW epimerase dehydratase BF36_43 ENOG4105JRK feS assembly protein SufD BF36_4301 ENOG4105DMQ Methyltransferase BF36_4302 ENOG4105E0A ABC, transporter BF36_4303 ENOG4108IHU transport system permease protein BF36_4304 ENOG4105DQ5 transport system permease protein BF36_4305 ENOG4108MES Periplasmic binding protein BF36_4306 ENOG4105DUX Transporter BF36_4309 ENOG4105DAA L-lactate BF36_431 ENOG4105BZN citrate synthase BF36_4310 ENOG4108IJ0 Aspartate ammonia-lyase BF36_4311 ENOG4105C37 (CBS) domain BF36_4312 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BF36_4313 ENOG4105D9N nucleoside BF36_4314 ENOG4108KGH TRANSCRIPTIONal BF36_4315 ENOG41073R8 VanW family BF36_432 ENOG4108HMX isocitrate dehydrogenase (NADP) BF36_4322 ENOG4105DAP Nicotinate phosphoribosyltransferase BF36_4323 ENOG4105C59 p-type ATPase BF36_4325 ENOG4105CUB amino acid BF36_4329 ENOG4108JB9 formate dehydrogenase BF36_4330 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BF36_4331 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BF36_4333 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_4334 ENOG4105BZU Histidine kinase BF36_4336 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BF36_4337 ENOG4108UZ3 Transporter BF36_4339 ENOG4105C6K Malic enzyme BF36_4341 ENOG4108MRH transcriptional regulatory protein BF36_4346 ENOG4105US7 Histidine kinase BF36_4347 ENOG4108STX response regulator BF36_4348 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BF36_4349 ENOG4105BZ7 extracellular solute-binding protein family 1 BF36_4350 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BF36_4351 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BF36_4352 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BF36_4353 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BF36_4357 ENOG4105D4T Citrate transporter BF36_4358 ENOG4108V9W transcriptional regulatory protein BF36_4359 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BF36_4361 ENOG4105DZ6 Band 7 protein BF36_4364 ENOG4105C94 Transporter BF36_4369 ENOG4105CYN Serine protein kinase BF36_437 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF36_4371 ENOG4105BZU Histidine kinase BF36_4372 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BF36_4374 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BF36_4376 ENOG4107ZQN disulfide bond BF36_4377 ENOG4108JQC penicillin-binding protein 1A BF36_438 ENOG4105BZU Histidine kinase BF36_439 ENOG4105C2M dna polymerase I BF36_44 ENOG4105C9B Cysteine desulfurase BF36_440 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BF36_4401 ENOG4105G5W regulator Fur family BF36_4402 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BF36_4406 ENOG4108IUW ABC transporter BF36_4408 ENOG4105CBC glutamate synthase BF36_4409 ENOG4107NBY Membrane BF36_4410 ENOG4105BZ1 (ABC) transporter BF36_4414 ENOG4106BXE BF36_4415 ENOG4105CEN a g-specific adenine glycosylase BF36_4416 ENOG41067AE Membrane-bound metal-dependent hydrolase BF36_442 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BF36_4422 ENOG4105ECP epimerase BF36_4423 ENOG4105CI2 imidazolone-5-propionate hydrolase BF36_4427 ENOG4105F1A Pyruvate formate-lyase BF36_443 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BF36_4430 ENOG4105C3I Nad-dependent epimerase dehydratase BF36_4431 ENOG4107QQG Dehydrogenase BF36_4432 ENOG4105CKK Glycosyl transferase, family 2 BF36_4435 ENOG4108A04 Beta-lactamase BF36_4437 ENOG4105CSV Glutaminase BF36_444 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF36_4444 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF36_4445 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF36_4452 ENOG4105UPD Calcium Proton BF36_4453 ENOG410606W general stress protein BF36_4456 ENOG4107ZTW SNARE associated Golgi BF36_4458 ENOG4105C3F Signal peptidase i BF36_4461 ENOG4108IPJ Membrane BF36_4462 ENOG4105C59 p-type ATPase BF36_4463 ENOG4107U9T Pfam:Ribonuclease_BN BF36_4465 ENOG4105KJF protein tyrosine phosphatase BF36_4469 ENOG4108TTB tellurium resistance protein BF36_4470 ENOG4107TS3 membrane protein, TerC BF36_4471 ENOG4106FN3 tellurium resistance protein BF36_4472 ENOG4106FN3 tellurium resistance protein BF36_4473 ENOG4108N0M stress protein BF36_4479 ENOG4105DEU major facilitator superfamily BF36_448 ENOG4108TDW sporulation protein YtxC BF36_4483 ENOG41062JF Transcriptional regulator BF36_4489 ENOG4105C5H ABC transporter BF36_449 ENOG4105C22 threonyL-tRNA synthetase BF36_4492 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BF36_4495 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BF36_45 ENOG4108UNV SUF system FeS assembly protein, NifU family BF36_450 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BF36_4501 ENOG4105CI1 PTS System BF36_4505 ENOG4105C5B carbamate kinase BF36_4510 ENOG4105C8Q Methyl-accepting chemotaxis BF36_4512 ENOG4105EAB amino acid AbC transporter BF36_4513 ENOG4105E5Q amino acid AbC transporter BF36_4516 ENOG4105D2S major facilitator superfamily BF36_4517 ENOG410756H nucleotidyltransferase BF36_4525 ENOG4106UIA BF36_4526 ENOG4106UIA BF36_4530 ENOG4108V5C ABC transporter BF36_4531 ENOG4105DQ5 transport system permease protein BF36_4532 ENOG4105EHG Permease protein BF36_4533 ENOG4107W7X Aldolase BF36_4535 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BF36_4536 ENOG4105D3R alkyl hydroperoxide reductase BF36_454 ENOG4105CN9 Peptidase m42 family protein BF36_4541 ENOG4105DFD Na H antiporter BF36_4542 ENOG4105DTQ mandelate racemase muconate lactonizing BF36_4545 ENOG4108W15 Protein of unknown function (DUF1456) BF36_4548 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BF36_4549 ENOG4105D9N nucleoside BF36_455 ENOG4108JGH Tetr family transcriptional regulator BF36_4553 ENOG4105KPY Small multidrug resistance protein BF36_4554 ENOG4105C26 Dehydrogenase BF36_4556 ENOG4108JPW Aminotransferase BF36_4557 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BF36_4558 ENOG4105CBD Diacylglycerol kinase BF36_456 ENOG4105CW7 secretion protein, HlyD family BF36_4562 ENOG4107I77 yiaA/B two helix domain BF36_4563 ENOG410834F Transcriptional regulator BF36_4567 ENOG4105D01 (LipO)protein BF36_4568 ENOG4108UMI ABC transporter, permease BF36_4569 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF36_457 ENOG4105C0R drug resistance transporter emrb qaca subfamily BF36_4570 ENOG4108W2Y isochorismatase BF36_4576 ENOG4105C4R Atp-dependent dna helicase BF36_4581 ENOG4105C12 Phosphoribosylglycinamide synthetase BF36_4583 ENOG4108V3E phosphoribosylglycinamide formyltransferase BF36_4588 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BF36_4590 ENOG4105C83 adenylosuccinate lyase BF36_4591 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BF36_4592 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BF36_4598 ENOG4105SX7 Transporter BF36_46 ENOG4105DIW FeS assembly protein SUFB BF36_4603 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF36_4612 ENOG4108SHN Glycosyl transferase, family 2 BF36_4616 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF36_4624 ENOG4107ZXU DSBA oxidoreductase BF36_4630 ENOG4105BZU Histidine kinase BF36_4632 ENOG4105C7N Xanthine uracil vitamin C permease BF36_4636 ENOG4108TYN CAAX amino terminal protease family protein BF36_4639 ENOG4105C5H ABC transporter BF36_464 ENOG4108RWN rrna methyltransferase BF36_4640 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF36_4641 ENOG410801F ribosomal-protein-alanine acetyltransferase BF36_4642 ENOG41072GX Peptidase M22 Glycoprotease BF36_4643 ENOG4105K8N protein family UPF0079, ATPase BF36_466 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BF36_4663 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BF36_4665 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BF36_4666 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BF36_4669 ENOG4107ZXI Rhomboid family BF36_467 ENOG4105C5S asparaginyl-tRNA synthetase BF36_4671 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BF36_4672 ENOG4105CPF Cell wall formation (By similarity) BF36_4673 ENOG4108SC4 )-transporter BF36_4675 ENOG4105ERH Fumarylacetoacetate hydrolase BF36_4676 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BF36_4682 ENOG410667J hydrolase BF36_4683 ENOG4108JQ7 (ABC) transporter BF36_4684 ENOG4105C3U ABC transporter BF36_4685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF36_4687 ENOG4105DEF Extracellular solute-binding protein, family 5 BF36_4690 ENOG4108KYE ABC-2 type transporter BF36_4691 ENOG41090VJ ABC-2 type transporter BF36_4692 ENOG4105CJ1 ABC, transporter BF36_4693 ENOG4105WH1 Two component transcriptional regulator luxr family BF36_4694 ENOG4105BZU Histidine kinase BF36_4695 ENOG4105C5H ABC transporter BF36_4699 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BF36_47 ENOG4107R8B 5'-nucleotidase BF36_4700 ENOG4108RE7 deoxyribonuclease BF36_4703 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BF36_4707 ENOG4105F6E Acyl-transferase BF36_4714 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BF36_4715 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BF36_4716 ENOG4105E0C molybdate abc transporter BF36_4718 ENOG4107XDY Nicotinamide Mononucleotide Transporter BF36_4719 ENOG4105II7 pyrroline-5-carboxylate reductase BF36_4721 ENOG4108J59 Extracellular solute-binding protein, family 5 BF36_4722 ENOG4108J59 Extracellular solute-binding protein, family 5 BF36_4728 ENOG4108JQ7 (ABC) transporter BF36_4729 ENOG4105C3U ABC transporter BF36_4730 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF36_4731 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BF36_4734 ENOG4105C2C drug resistance transporter, Bcr CflA BF36_4737 ENOG4105IQ5 FAD linked oxidase domain protein BF36_4739 ENOG4105EE1 crotonyl-CoA reductase BF36_474 ENOG4105DCG PHP domain protein BF36_4740 ENOG4105D01 (LipO)protein BF36_4741 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BF36_4742 ENOG4108UMI ABC transporter, permease BF36_4743 ENOG4108PSK reductase BF36_4751 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BF36_4753 ENOG4105CMG Carbohydrate kinase BF36_4755 ENOG4108VQT Alpha beta hydrolase fold protein BF36_4758 ENOG4107U5W ybbr family BF36_4759 ENOG4105C8B TIGR00159 family BF36_477 ENOG4105FE9 pseudouridine synthase BF36_4776 ENOG4108NMV polysaccharide deacetylase BF36_4779 ENOG4105D1F ATP-binding protein BF36_4784 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BF36_4785 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BF36_4786 ENOG4108JJB ABC transporter BF36_479 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BF36_4792 ENOG41067V7 50S ribosomal protein L36 BF36_4794 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BF36_4796 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BF36_48 ENOG4105KZD Domain of unknown function (DUF1805) BF36_480 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BF36_4801 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BF36_4822 ENOG4105XPM ribosomal protein BF36_4825 ENOG4107Y49 methyltransferase BF36_483 ENOG4105E0A ABC, transporter BF36_4830 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BF36_4832 ENOG4105QIV RNA polymerase BF36_4833 ENOG4105M0M Tetracycline resistance protein BF36_4834 ENOG4105C2N RNA methyltransferase TrmH family group 3 BF36_4837 ENOG4105D7W serine acetyltransferase BF36_484 ENOG4105KFN sortase, SrtB family BF36_4841 ENOG4105CTP PilT protein domain protein BF36_4843 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BF36_4846 ENOG4108Z0C Uvrb UvrC protein BF36_4866 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BF36_4868 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BF36_4869 ENOG4105KRF dihydroneopterin aldolase BF36_487 ENOG4105DR4 Methyltransferase BF36_4870 ENOG4105EEI dihydropteroate synthase BF36_4871 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BF36_4872 ENOG4105DDQ anthranilate synthase BF36_4873 ENOG4105CRQ synthase (Component I) BF36_4874 ENOG4105C6T cysteine synthase BF36_4877 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BF36_4878 ENOG4108UGV hypoxanthine phosphoribosyltransferase BF36_4883 ENOG41060GV RNA binding s1 domain protein BF36_4886 ENOG4105VYY sporulation protein yabp BF36_4887 ENOG41082I2 s4 domain protein BF36_4888 ENOG4108IY2 MazG family BF36_4890 ENOG4108M14 stage v sporulation protein t BF36_4891 ENOG4108JA2 transcriptioN-repair coupling factor BF36_4894 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BF36_4897 ENOG4105KME endoribonuclease L-psp BF36_4898 ENOG4105DFT pur operon repressor BF36_490 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BF36_4901 ENOG4105W42 Veg protein BF36_4902 ENOG4105XFA sporulation peptidase YabG BF36_4904 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BF36_4905 ENOG4105F8V Hydrolase, tatD family BF36_4907 ENOG4105KRN Transcriptional regulator, abrb family BF36_4908 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BF36_4910 ENOG41060K3 Methyltransferase BF36_4912 ENOG4105MA4 psp1 domain protein BF36_4913 ENOG4105FA2 dna polymerase iii BF36_4915 ENOG4105CXN decarboxylase BF36_4923 ENOG41067KS pro-sigma K processing BF36_4927 ENOG4105C6E dna polymerase iii BF36_4928 ENOG4108Z6B deaminase BF36_4929 ENOG4105GTG Isochorismatase BF36_4931 ENOG4105ZMH deoxynucleoside kinase BF36_4938 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BF36_4946 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BF36_4949 ENOG410848D S4 domain protein YaaA BF36_4950 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BF36_4954 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BF36_4956 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BF36_4960 ENOG4107QJE Chromosome Partitioning Protein BF36_4961 ENOG4105FA0 parb-like partition protein BF36_4962 ENOG4108ZDA Sporulation protein YyaC BF36_4963 ENOG4105D8X mechanosensitive ion channel BF36_4964 ENOG4105VDK protein, conserved in bacteria BF36_4965 ENOG4105C3G gtp-binding protein BF36_4967 ENOG4108UUM single-stranded DNA-binding protein BF36_4969 ENOG4108XMW Membrane BF36_4970 ENOG4105BZR domain protein BF36_4972 ENOG4105CDU Replicative dna helicase BF36_4978 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_4979 ENOG4105BZU Histidine kinase BF36_498 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF36_4982 ENOG4105Q2H domain protein BF36_4983 ENOG4105C0H protease BF36_4987 ENOG4105DPN Oligoendopeptidase f BF36_499 ENOG4105J76 Periplasmic binding protein BF36_4990 ENOG4105C1J atp-dependent rna helicase BF36_4992 ENOG4108UT2 hemolysin iii BF36_4993 ENOG4105CMR udp-glucose 4-epimerase BF36_4995 ENOG4105IW1 AmiS UreI transporter BF36_4997 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF36_50 ENOG4105FAA peptidase M23 BF36_5000 ENOG4107RGD Major Facilitator superfamily BF36_5001 ENOG4108HRK Histidine kinase BF36_5002 ENOG4105DY9 regulatoR BF36_5005 ENOG4106F5Q Membrane BF36_5006 ENOG4105E0X reductase BF36_5008 ENOG41067SE Tetr family transcriptional regulator BF36_5009 ENOG4105CKK Glycosyl transferase, family 2 BF36_501 ENOG4105CEY Amp-dependent synthetase and ligase BF36_5013 ENOG4105C5H ABC transporter BF36_5014 ENOG4105JEU Glycosyl transferase, family 2 BF36_5016 ENOG4108S4H thioesterase Superfamily protein BF36_5018 ENOG4106YBV Methyl-accepting chemotaxis BF36_5019 ENOG4105EN6 Membrane BF36_502 ENOG4107Z3H Transcriptional regulator, TetR family BF36_5023 ENOG41079KZ Major Facilitator Superfamily BF36_5024 ENOG4105DY9 regulatoR BF36_5025 ENOG4105D22 carbon starvation protein BF36_5026 ENOG4105VCD cytoplasmic protein BF36_5027 ENOG4105BZU Histidine kinase BF36_5028 ENOG4105DWF phosphomethylpyrimidine kinase BF36_5029 ENOG4105BZU Histidine kinase BF36_503 ENOG41060WC Enoyl-CoA hydratase BF36_5030 ENOG4105WH1 Two component transcriptional regulator luxr family BF36_5032 ENOG4108Y4K DNA-binding transcriptional activator BF36_5037 ENOG4105D6E homoserine dehydrogenase BF36_504 ENOG4105BZJ Electron transfer flavoprotein BF36_5040 ENOG41090WU lipolytic protein G-D-S-L family BF36_5041 ENOG4105CJ1 ABC, transporter BF36_5042 ENOG4108TU7 Inherit from COG: (ABC) transporter BF36_5044 ENOG4105VCH membrane BF36_5045 ENOG410667J hydrolase BF36_5047 ENOG4107SVH Potassium channel protein BF36_505 ENOG4105C10 Electron transfer flavoprotein BF36_5051 ENOG4108VKI Cell wall hydrolase BF36_5054 ENOG4108IJ2 phosphate acetyltransferase BF36_5057 ENOG4108VCI transcription factor, rsfa family BF36_5059 ENOG4105DQ5 transport system permease protein BF36_506 ENOG4105K63 Thioredoxin BF36_5060 ENOG4105EHG Permease protein BF36_5061 ENOG4105E0A ABC, transporter BF36_5062 ENOG4108MES Periplasmic binding protein BF36_5063 ENOG4105DCI Phosphohydrolase BF36_5064 ENOG41069HH 4-oxalocrotonate tautomerase BF36_5065 ENOG4108Z4T Peptidase M50 BF36_5066 ENOG4108XFG YwhD family BF36_5067 ENOG4105BZ4 penicillin-binding protein BF36_5068 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF36_5069 ENOG4107SWG transcriptional regulator MERR family BF36_5070 ENOG4105DXB Major Facilitator superfamily BF36_5072 ENOG4105CYW agmatinase BF36_5076 ENOG410684U Domain of unknown function (DUF1934) BF36_5078 ENOG4105EMN RNA polymerase sigma factor BF36_5082 ENOG4105IIU Aminopeptidase BF36_5085 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BF36_5086 ENOG4108M15 ABC transporter BF36_5087 ENOG4105KCT ABC transporter BF36_5088 ENOG4105BZU Histidine kinase BF36_509 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BF36_5093 ENOG4105BZU Histidine kinase BF36_5096 ENOG4105DF6 Fe-S oxidoreductase BF36_5098 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BF36_5099 ENOG4105C1G acyl-Coa dehydrogenase BF36_5100 ENOG4105C1G acyl-Coa dehydrogenase BF36_5107 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BF36_5108 ENOG4105CBT Fructose-1,6-bisphosphatase BF36_5109 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BF36_511 ENOG4105E33 succinate dehydrogenase BF36_5112 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BF36_5113 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BF36_5114 ENOG4108ZXQ stage ii sporulation protein r BF36_5116 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BF36_5120 ENOG4107XC4 flavin reductase domain protein, FMN-binding BF36_5121 ENOG4108VGI doxx family BF36_5124 ENOG4108YZG isomerase BF36_5129 ENOG41062M3 atp synthase BF36_513 ENOG4108VXD carboxy-peptidase BF36_5130 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BF36_514 ENOG4105E14 MotA TolQ exbB proton channel BF36_5140 ENOG4105BZU Histidine kinase BF36_5141 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF36_5143 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BF36_5144 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF36_5149 ENOG4105D65 subunit l BF36_515 ENOG4105ER2 Ompa motb domain protein BF36_5150 ENOG4105C8S subunit m BF36_5151 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BF36_5152 ENOG4106778 Protein of unknown function (DUF1146) BF36_5156 ENOG4105DY9 regulatoR BF36_5159 ENOG4105FRN stage II sporulation protein BF36_516 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BF36_5161 ENOG4107BJW polysaccharide deacetylase BF36_5162 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BF36_5168 ENOG4107VDP teichoic acid biosynthesis BF36_517 ENOG4108IUX (ABC) transporter BF36_5172 ENOG4105EY8 ABC transporter BF36_5173 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF36_5177 ENOG4105CMR udp-glucose 4-epimerase BF36_5178 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_5179 ENOG4105BZU Histidine kinase BF36_518 ENOG4105RHA ABC transporter, permease BF36_5182 ENOG4105CXY transporter BF36_5184 ENOG4105C19 ABC transporter BF36_5185 ENOG4107RBB ABC transporter, permease BF36_5187 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF36_519 ENOG4108Z40 Transcriptional regulator BF36_5193 ENOG4105C0D helicase BF36_5194 ENOG4105KBK Zinc finger, swim domain protein BF36_5199 ENOG41069ER domain protein BF36_520 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BF36_5200 ENOG4105C94 Transporter BF36_5202 ENOG4107R8N Glycosyl transferase, family 2 BF36_5207 ENOG4105E0M Sulfatase BF36_5209 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BF36_5211 ENOG4105DAA L-lactate BF36_5218 ENOG4107RSM transcriptional regulator BF36_5219 ENOG4105ECB domain protein BF36_522 ENOG4108JCI Transcriptional regulator BF36_5220 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BF36_5223 ENOG4105VZJ PTS System BF36_5225 ENOG4105VCP PTS System BF36_5226 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BF36_5227 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BF36_5229 ENOG4105CK1 PTS System BF36_523 ENOG41067S9 phage shock protein C, PspC BF36_5230 ENOG4105VCP PTS System BF36_5231 ENOG4105F8D glycoside hydrolase family 4 BF36_5235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BF36_5237 ENOG4105ESV Glycosyl transferase, family 4 BF36_5238 ENOG4105C6Y Udp-glucose 6-dehydrogenase BF36_5239 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BF36_5240 ENOG4108KGH TRANSCRIPTIONal BF36_5241 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BF36_5243 ENOG4105KVH Transcriptional regulator BF36_5246 ENOG41081UC Inherit from COG: Competence protein BF36_5247 ENOG4105VEQ Cold shock protein BF36_5248 ENOG4105MS2 ribosomal subunit Interface protein BF36_5250 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BF36_5252 ENOG4105CAK Cell division ATP-binding protein ftsE BF36_5253 ENOG4105CRP Part of the ABC transporter FtsEX involved in BF36_5254 ENOG4105CN1 protease BF36_5256 ENOG4105BZ1 (ABC) transporter BF36_5259 ENOG4108WS4 fmn reductase BF36_5261 ENOG4105DUM transcriptional regulator, lysR family BF36_5262 ENOG4105HMI Membrane BF36_5268 ENOG4107TXC Transcriptional regulator BF36_527 ENOG4105DY9 regulatoR BF36_5272 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BF36_5274 ENOG41086DT Membrane protein of unknown function BF36_5278 ENOG4108S4C acetyltransferase BF36_528 ENOG4108HRK Histidine kinase BF36_5280 ENOG4105C3M thioredoxin reductase BF36_5282 ENOG4108Z4K mutator MutT protein BF36_5284 ENOG4105CHW UPF0052 protein BF36_5286 ENOG4105KRI phosphocarrier protein (HPr BF36_5287 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BF36_5288 ENOG4105H67 Protein of unknown function (DUF421) BF36_529 ENOG4108JQ7 (ABC) transporter BF36_5291 ENOG4105CZ3 stage V sporulation protein ad BF36_5292 ENOG41090VF Stage v sporulation protein ac BF36_5296 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF36_5302 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BF36_5306 ENOG41067MG lrgb family BF36_5307 ENOG4105XZU Preprotein translocase, subunit SecG BF36_5309 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BF36_5315 ENOG4105CM4 permease protein BF36_5316 ENOG4108IPW abc transporter atp-binding protein BF36_5319 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BF36_532 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BF36_5320 ENOG4108MK9 spermidine N(1)-acetyltransferase BF36_5326 ENOG4105C8Q Methyl-accepting chemotaxis BF36_533 ENOG4105DEF Extracellular solute-binding protein, family 5 BF36_5330 ENOG4105D4A Cell wall formation (By similarity) BF36_5331 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BF36_5334 ENOG4105KVH Transcriptional regulator BF36_5335 ENOG4105F27 Major Facilitator BF36_5336 ENOG4105CV8 reductase BF36_534 ENOG4105DZC cytosine deaminase BF36_5340 ENOG4108RYK Nad-dependent epimerase dehydratase BF36_5342 ENOG4105D9N nucleoside BF36_5343 ENOG4105D9N nucleoside BF36_5347 ENOG4108URH decarboxylase BF36_535 ENOG4105DZC cytosine deaminase BF36_5350 ENOG4108RMU ferritin dps family protein BF36_5352 ENOG4105NCW Trka-c domain protein BF36_5353 ENOG4107S91 Sodium hydrogen exchanger BF36_5357 ENOG4105D4Y metalloprotease BF36_5358 ENOG4105VG1 fes assembly suf system protein BF36_5359 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF36_5360 ENOG4105C8Q Methyl-accepting chemotaxis BF36_5364 ENOG4105BZU Histidine kinase BF36_5365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BF36_5366 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BF36_5368 ENOG4107ZTW SNARE associated Golgi BF36_5376 ENOG4107AYK membrAne BF36_538 ENOG4105PFC Transcriptional regulator BF36_5380 ENOG41061CK Antibiotic biosynthesis monooxygenase BF36_5384 ENOG4107QJE Chromosome Partitioning Protein BF36_5403 ENOG4108IMY Transcriptional regulator BF36_541 ENOG4105KBX Transcriptional regulator, TetR family BF36_5415 ENOG4106CVF DNA replication protein BF36_5422 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BF36_543 ENOG4108PCX Major Facilitator BF36_5434 ENOG4108MDF Phage Portal Protein BF36_5435 ENOG4106CGH Phage Mu protein F like protein BF36_5441 ENOG41060SN BF36_545 ENOG4108XJQ germination protein BF36_5457 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF36_547 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BF36_548 ENOG4105M59 Phosphodiesterase, mj0936 family BF36_55 ENOG41090T1 Membrane BF36_552 ENOG4108QCI YvbH-like oligomerisation region BF36_559 ENOG4108IUQ atp-dependent protease BF36_56 ENOG4107TXC Transcriptional regulator BF36_563 ENOG4105K56 Transcriptional regulator BF36_568 ENOG4105D52 delta-aminolevulinic acid dehydratase BF36_57 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BF36_570 ENOG41068KH stage VI sporulation protein D BF36_572 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BF36_573 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BF36_577 ENOG4105DFF Rod shape-determining protein mreb BF36_578 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BF36_58 ENOG4105MMD transcriptional regulator BF36_581 ENOG4107QMS site-determining protein BF36_584 ENOG4105C03 ribonuclease BF36_586 ENOG4105X36 (ribosomal) protein BF36_591 ENOG4105EWM Histidine kinase BF36_595 ENOG4105CQC Prephenate dehydratase BF36_596 ENOG4108RPX mosc domain containing protein BF36_599 ENOG4108IYU L-aspartate oxidase BF36_600 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BF36_605 ENOG41082BM Transcriptional regulator, arsr family BF36_606 ENOG4108IPJ Membrane BF36_608 ENOG4108HUF Transporter BF36_61 ENOG4105CBT Fructose-1,6-bisphosphatase BF36_611 ENOG41061AI Protein of unknown function (DUF2905) BF36_614 ENOG4105VIE preprotein translocase, subunit YajC BF36_616 ENOG4108QG2 Membrane BF36_617 ENOG4105CKP Polysaccharide Biosynthesis Protein BF36_619 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BF36_620 ENOG41076HS cation diffusion facilitator family transporter BF36_621 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BF36_623 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BF36_626 ENOG4105CUT histidyl-tRNA synthetase BF36_628 ENOG4105CUZ uba thif-type nad fad binding protein BF36_629 ENOG4108VCI transcription factor, rsfa family BF36_630 ENOG4105D1H recombination factor protein RarA BF36_632 ENOG4105C3J Cysteine desulfurase BF36_635 ENOG4105C7H Helicase, RecD TraA family BF36_636 ENOG41060CR BF36_639 ENOG4105C02 permease BF36_64 ENOG4105D4U had-superfamily hydrolase, subfamily iia BF36_645 ENOG4105HHA aminodeoxychorismate lyase BF36_646 ENOG4108VQJ O-methyltransferase BF36_647 ENOG4105XYU peptidase (U32 family) BF36_648 ENOG4105CFP Peptidase U32 BF36_651 ENOG4107XRG penicillin-binding protein BF36_657 ENOG4105C28 cystathionine BF36_658 ENOG4108EKI Dehydrogenase BF36_66 ENOG4105DYS nad(p)h dehydrogenase (quinone) BF36_660 ENOG4108V5C ABC transporter BF36_661 ENOG4105S6R Iron-hydroxamate transporter permease subunit BF36_669 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BF36_671 ENOG4105MIR Phenylalanine 4-monooxygenase BF36_672 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BF36_679 ENOG4108MUZ hydrolase BF36_68 ENOG4108W5N phosphatidylglycerophosphatase a BF36_681 ENOG4105G6Z alkaline phosphatase BF36_684 ENOG4108TVJ Nitroreductase BF36_688 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF36_691 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BF36_692 ENOG4105CQW ribosome biogenesis GTPase YqeH BF36_694 ENOG410812S Rna-binding protein BF36_696 ENOG4108WF2 Metal Dependent Phosphohydrolase BF36_698 ENOG4105DXX methyltransferase BF36_700 ENOG4105KQC Competence protein BF36_701 ENOG4108UK2 deaminase BF36_702 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BF36_704 ENOG4105TQK DNA polymerase iii, delta' subunit BF36_709 ENOG4105KVH Transcriptional regulator BF36_71 ENOG41083MR nifu domain-containing protein BF36_710 ENOG4105CSA Coproporphyrinogen iii oxidase BF36_712 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BF36_716 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BF36_717 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BF36_719 ENOG4105KTH gatB Yqey BF36_720 ENOG41068P3 sporulation protein YqfC BF36_722 ENOG4105C9A Phoh family BF36_723 ENOG4105CTJ Metal Dependent Phosphohydrolase BF36_725 ENOG4107YR5 Diacylglycerol kinase BF36_726 ENOG4105KG3 cytidine deaminase BF36_727 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BF36_732 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BF36_733 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF36_736 ENOG4105EGD dinuclear metal center protein, YbgI family BF36_741 ENOG41069ZM Protein of unknown function (DUF2624) BF36_742 ENOG4108JYZ YitT family BF36_743 ENOG4105FDK ABC transporter BF36_745 ENOG4105N80 Ferric uptake regulator, Fur family BF36_750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BF36_752 ENOG4107RF6 penicillin-binding protein BF36_753 ENOG4105PWN phosphate abc transporter BF36_754 ENOG4105C8U phosphate abc transporter BF36_755 ENOG4105E2Z phosphate ABC transporter (Permease BF36_756 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BF36_757 ENOG4108UTW Plays a role in the regulation of phosphate uptake BF36_76 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BF36_760 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BF36_762 ENOG4105DKQ ROK family BF36_764 ENOG4105C5X domain protein BF36_768 ENOG4105C28 cystathionine BF36_769 ENOG4105C28 cystathionine BF36_77 ENOG4105C4B ABC transporter, permease BF36_771 ENOG4105C3R Methionine synthase BF36_772 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BF36_78 ENOG4108JJA ABC, transporter BF36_795 ENOG4105C0D helicase BF36_8 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BF36_801 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF36_809 ENOG41080TC multidrug resistance protein BF36_813 ENOG4105WZW rhodanese family BF36_814 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BF36_82 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BF36_822 ENOG4107YBY Hydrolase BF36_823 ENOG4105CBJ Metal-dependent enzyme BF36_826 ENOG4105DC7 peptidase M24 BF36_831 ENOG4105CD2 stage iii sporulation protein aa BF36_832 ENOG4105KR5 Stage iii sporulation protein BF36_833 ENOG4108CQH stage III sporulation protein AC BF36_834 ENOG4105KQ4 Stage iii sporulation protein ad BF36_836 ENOG410644B Stage III sporulation protein af BF36_84 ENOG4105EWC Purine nucleoside phosphorylase BF36_841 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BF36_842 ENOG4108ZSR alkaline shock protein BF36_847 ENOG4105CTB Polyprenyl synthetase BF36_849 ENOG4105DX0 Hemolysin A BF36_851 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BF36_852 ENOG4105S1Z Stage IV sporulation protein B BF36_853 ENOG4107QQR Sporulation BF36_856 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BF36_858 ENOG4108JUB Transcriptional regulator BF36_860 ENOG4107RDP Dehydrogenase BF36_864 ENOG4105CPP Dehydrogenase, E1 component BF36_865 ENOG4105C7S Dehydrogenase BF36_867 ENOG4105E09 nadh pyrophosphatase BF36_868 ENOG4105G7B Protein of unknown function (DUF2992) BF36_870 ENOG4108HW3 (ABC) transporter BF36_871 ENOG4105E5Q amino acid AbC transporter BF36_872 ENOG4105CDA abc transporter atp-binding protein BF36_873 ENOG4108QEG Membrane BF36_874 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BF36_876 ENOG4105D9U N-acetyltransferase BF36_877 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BF36_879 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BF36_883 ENOG4105EJQ L-serine dehydratase BF36_884 ENOG4105II7 pyrroline-5-carboxylate reductase BF36_885 ENOG41069FQ Metallo-beta-lactamase superfamily BF36_886 ENOG4108IXY short-chain dehydrogenase reductase BF36_889 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BF36_897 ENOG4105CGH 5'-nucleotidase BF36_898 ENOG4105DFD Na H antiporter BF36_90 ENOG4105CEP NADH dehydrogenase BF36_900 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BF36_902 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BF36_903 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF36_904 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BF36_905 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BF36_909 ENOG4108R6K riboflavin synthase, subunit alpha BF36_910 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BF36_914 ENOG4108YM7 Gcn5-related n-acetyltransferase BF36_915 ENOG4105ETE Transcriptional regulator (LacI family BF36_917 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BF36_921 ENOG4105RHY Pfam:UPF0157 BF36_923 ENOG4105CPC Aldo Keto reductase BF36_927 ENOG4105MZ9 stage II sporulation protein m BF36_928 ENOG4105I3K Ferric uptake regulator, Fur family BF36_93 ENOG41069ER domain protein BF36_930 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BF36_935 ENOG4105D7N magnesium and cobalt transport protein CorA BF36_942 ENOG4105DVE abc transporter atp-binding protein BF36_943 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BF36_944 ENOG4105DZ1 carboxypeptidase BF36_945 ENOG4105DZ1 carboxypeptidase BF36_946 ENOG41082AN stage II sporulation protein BF36_948 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BF36_949 ENOG4105C8J )-transporter BF36_953 ENOG41090VF Stage v sporulation protein ac BF36_954 ENOG4105CZ3 stage V sporulation protein ad BF36_956 ENOG4105G6R Stage v sporulation protein ae BF36_958 ENOG4105J7I hydrolase BF36_959 ENOG4105PTM secreted protein BF36_960 ENOG4107ZE5 PPIases accelerate the folding of proteins BF36_967 ENOG4105CE4 GlcNAc 6-P deacetylase BF36_969 ENOG4105FDP GntR family transcriptional regulator BF36_97 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BF36_971 ENOG4105CID antiterminator BF36_974 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BF36_978 ENOG4106TD9 Diguanylate cyclase BF36_979 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BF36_987 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BF36_989 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BF36_991 ENOG4105DTD Dehydrogenase BF36_992 ENOG4105K7K Transcriptional regulator BF36_999 ENOG4105CHU acetyl-coa acetyltransferase