locus-tag class description HBA75_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HBA75_00015 ENOG410848D S4 domain protein YaaA HBA75_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBA75_00145 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HBA75_00180 ENOG4105ZMH deoxynucleoside kinase HBA75_00190 ENOG4105GTG Isochorismatase HBA75_00195 ENOG4108Z6B deaminase HBA75_00205 ENOG4105C6E dna polymerase iii HBA75_00225 ENOG41067KS pro-sigma K processing HBA75_00260 ENOG4105CXN decarboxylase HBA75_00270 ENOG4105FA2 dna polymerase iii HBA75_00275 ENOG4105MA4 psp1 domain protein HBA75_00285 ENOG41060K3 Methyltransferase HBA75_00305 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HBA75_00310 ENOG4105KRN Transcriptional regulator, abrb family HBA75_00315 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HBA75_00320 ENOG4105F8V Hydrolase, tatD family HBA75_00325 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) HBA75_00335 ENOG4105XFA sporulation peptidase YabG HBA75_00340 ENOG4105W42 Veg protein HBA75_00355 ENOG4105DFT pur operon repressor HBA75_00360 ENOG4105KME endoribonuclease L-psp HBA75_00380 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HBA75_00390 ENOG4108JA2 transcriptioN-repair coupling factor HBA75_00395 ENOG4108M14 stage v sporulation protein t HBA75_00405 ENOG4108IY2 MazG family HBA75_00410 ENOG41082I2 s4 domain protein HBA75_00415 ENOG4105VYY sporulation protein yabp HBA75_00430 ENOG41060GV RNA binding s1 domain protein HBA75_00450 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HBA75_00455 ENOG4108UGV hypoxanthine phosphoribosyltransferase HBA75_00460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HBA75_00475 ENOG4105C6T cysteine synthase HBA75_00480 ENOG4105CRQ synthase (Component I) HBA75_00485 ENOG4105DDQ anthranilate synthase HBA75_00490 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HBA75_00495 ENOG4105EEI dihydropteroate synthase HBA75_00500 ENOG4105KRF dihydroneopterin aldolase HBA75_00505 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HBA75_00515 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HBA75_00605 ENOG4108Z0C Uvrb UvrC protein HBA75_00620 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HBA75_00630 ENOG4105CTP PilT protein domain protein HBA75_00635 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HBA75_00650 ENOG4105D7W serine acetyltransferase HBA75_00665 ENOG4105C2N RNA methyltransferase TrmH family group 3 HBA75_00670 ENOG4105M0M Tetracycline resistance protein HBA75_00675 ENOG4105QIV RNA polymerase HBA75_00690 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HBA75_00715 ENOG4107Y49 methyltransferase HBA75_00730 ENOG4105XPM ribosomal protein HBA75_00860 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HBA75_00870 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HBA75_00905 ENOG4108JJB ABC transporter HBA75_00910 ENOG4108JJB ABC transporter HBA75_00915 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HBA75_00920 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HBA75_00945 ENOG4105D1F ATP-binding protein HBA75_00960 ENOG4108NMV polysaccharide deacetylase HBA75_01030 ENOG4105C8B TIGR00159 family HBA75_01035 ENOG4107U5W ybbr family HBA75_01050 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HBA75_01075 ENOG4108PSK reductase HBA75_01080 ENOG4108UMI ABC transporter, permease HBA75_01085 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBA75_01090 ENOG4105D01 (LipO)protein HBA75_01095 ENOG4105CB2 alcohol dehydrogenase HBA75_01105 ENOG4105IQ5 FAD linked oxidase domain protein HBA75_01120 ENOG4105C2C drug resistance transporter, Bcr CflA HBA75_01135 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HBA75_01145 ENOG4105C3U ABC transporter HBA75_01150 ENOG4108JQ7 (ABC) transporter HBA75_01185 ENOG4108J59 Extracellular solute-binding protein, family 5 HBA75_01190 ENOG4108J59 Extracellular solute-binding protein, family 5 HBA75_01200 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_01210 ENOG4105E0C molybdate abc transporter HBA75_01215 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HBA75_01225 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HBA75_01235 ENOG4105EGI Transcriptional regulator HBA75_01255 ENOG4105F6E Acyl-transferase HBA75_01275 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HBA75_01290 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HBA75_01315 ENOG4105C5H ABC transporter HBA75_01325 ENOG4105DEF Extracellular solute-binding protein, family 5 HBA75_01355 ENOG4105C3U ABC transporter HBA75_01360 ENOG4108JQ7 (ABC) transporter HBA75_01365 ENOG410667J hydrolase HBA75_01395 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HBA75_01400 ENOG4105ERH Fumarylacetoacetate hydrolase HBA75_01410 ENOG4105CUB amino acid HBA75_01415 ENOG4108SC4 )-transporter HBA75_01420 ENOG4105CPF Cell wall formation (By similarity) HBA75_01425 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HBA75_01450 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HBA75_01455 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HBA75_01465 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HBA75_01580 ENOG4105K8N protein family UPF0079, ATPase HBA75_01585 ENOG41072GX Peptidase M22 Glycoprotease HBA75_01590 ENOG410801F ribosomal-protein-alanine acetyltransferase HBA75_01595 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HBA75_01600 ENOG4105C5H ABC transporter HBA75_01615 ENOG4108TYN CAAX amino terminal protease family protein HBA75_01630 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HBA75_01635 ENOG4105C7N Xanthine uracil vitamin C permease HBA75_01645 ENOG4105BZU Histidine kinase HBA75_01670 ENOG4107ZXU DSBA oxidoreductase HBA75_01715 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_01745 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_01790 ENOG4108SHN Glycosyl transferase, family 2 HBA75_01810 ENOG4105SX7 Transporter HBA75_01840 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HBA75_01845 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HBA75_01850 ENOG4105C83 adenylosuccinate lyase HBA75_01860 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HBA75_01885 ENOG4108V3E phosphoribosylglycinamide formyltransferase HBA75_01895 ENOG4105C12 Phosphoribosylglycinamide synthetase HBA75_01920 ENOG4105C4R Atp-dependent dna helicase HBA75_01925 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HBA75_01945 ENOG4108W2Y isochorismatase HBA75_01950 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBA75_01955 ENOG4108UMI ABC transporter, permease HBA75_01960 ENOG4105D01 (LipO)protein HBA75_01980 ENOG410834F Transcriptional regulator HBA75_01985 ENOG4107I77 yiaA/B two helix domain HBA75_02005 ENOG4105CBD Diacylglycerol kinase HBA75_02015 ENOG4108JPW Aminotransferase HBA75_02025 ENOG4105C26 Dehydrogenase HBA75_02030 ENOG4105KPY Small multidrug resistance protein HBA75_02065 ENOG4105D9N nucleoside HBA75_02070 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HBA75_02075 ENOG4105VTR Integrase HBA75_02090 ENOG41067QW Transcriptional regulator HBA75_02235 ENOG4108A04 Beta-lactamase HBA75_02250 ENOG4105CKK Glycosyl transferase, family 2 HBA75_02255 ENOG4107QQG Dehydrogenase HBA75_02260 ENOG4105C3I Nad-dependent epimerase dehydratase HBA75_02280 ENOG4105F1A Pyruvate formate-lyase HBA75_02300 ENOG4105CI2 imidazolone-5-propionate hydrolase HBA75_02305 ENOG4105ECP epimerase HBA75_02335 ENOG41067AE Membrane-bound metal-dependent hydrolase HBA75_02340 ENOG4105CEN a g-specific adenine glycosylase HBA75_02345 ENOG4106BXE HBA75_02365 ENOG4105BZ1 (ABC) transporter HBA75_02370 ENOG4107NBY Membrane HBA75_02375 ENOG4105CBC glutamate synthase HBA75_02385 ENOG4108IUW ABC transporter HBA75_02405 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_02410 ENOG4105G5W regulator Fur family HBA75_02530 ENOG4108JQC penicillin-binding protein 1A HBA75_02535 ENOG4108R9S DSBA oxidoreductase HBA75_02545 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HBA75_02555 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HBA75_02560 ENOG4105BZU Histidine kinase HBA75_02565 ENOG4105CYN Serine protein kinase HBA75_02585 ENOG4105C94 Transporter HBA75_02600 ENOG4105DZ6 Band 7 protein HBA75_02610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HBA75_02615 ENOG4108V9W transcriptional regulatory protein HBA75_02620 ENOG4105D4T Citrate transporter HBA75_02640 ENOG410836F Transposase HBA75_02650 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HBA75_02655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HBA75_02660 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HBA75_02665 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HBA75_02670 ENOG4105BZ7 extracellular solute-binding protein family 1 HBA75_02680 ENOG4105DQ6 Transposase HBA75_02685 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HBA75_02690 ENOG4108STX response regulator HBA75_02695 ENOG41062D9 Histidine kinase HBA75_02720 ENOG4108MRH transcriptional regulatory protein HBA75_02730 ENOG4105C6K Malic enzyme HBA75_02740 ENOG4108UZ3 Transporter HBA75_02745 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_02755 ENOG4105BZU Histidine kinase HBA75_02760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_02765 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HBA75_02770 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HBA75_02780 ENOG4108JB9 formate dehydrogenase HBA75_02800 ENOG4105CUB amino acid HBA75_02815 ENOG4105C59 p-type ATPase HBA75_02820 ENOG4105DAP Nicotinate phosphoribosyltransferase HBA75_02855 ENOG41073R8 VanW family HBA75_02860 ENOG4108KGH TRANSCRIPTIONal HBA75_02865 ENOG4105D9N nucleoside HBA75_02875 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HBA75_02880 ENOG41085W3 Transposase HBA75_02885 ENOG4105C37 (CBS) domain HBA75_02890 ENOG4108IJ0 Aspartate ammonia-lyase HBA75_02895 ENOG4105DAA L-lactate HBA75_02910 ENOG4105DUX Transporter HBA75_02915 ENOG4108MES Periplasmic binding protein HBA75_02920 ENOG4105DQ5 transport system permease protein HBA75_02925 ENOG4108IHU transport system permease protein HBA75_02930 ENOG4105E0A ABC, transporter HBA75_02935 ENOG4105DMQ Methyltransferase HBA75_02945 ENOG4105EKQ RNA-directed DNA polymerase HBA75_02955 ENOG4105EXW epimerase dehydratase HBA75_02960 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HBA75_02970 ENOG4107T89 von Willebrand factor, type A HBA75_02975 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HBA75_02980 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HBA75_02990 ENOG4105BZU Histidine kinase HBA75_02995 ENOG4105D5Q Arginine ornithine antiporter HBA75_03000 ENOG4107414 GntR family transcriptional regulator HBA75_03005 ENOG4105C5Y PTS System HBA75_03010 ENOG4105CG3 alpha amylase, catalytic region HBA75_03025 ENOG4105E1K spore germination protein HBA75_03030 ENOG4105CRN Aminoglycoside phosphotransferase HBA75_03035 ENOG4105BZG amino acid carrier protein HBA75_03040 ENOG4105CDA abc transporter atp-binding protein HBA75_03045 ENOG4105CT1 (ABC) transporter HBA75_03050 ENOG4105EAD ABC transporter HBA75_03055 ENOG4105DRP amino acid AbC transporter HBA75_03060 ENOG4108IQI permease HBA75_03085 ENOG4105D29 Helix-turn-helix type 11 domain protein HBA75_03090 ENOG4105NAE bifunctional deaminase-reductase domain protein HBA75_03095 ENOG4105BZU Histidine kinase HBA75_03100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_03110 ENOG4105CHH sulfate transporter HBA75_03115 ENOG41068KF Universal stress protein HBA75_03125 ENOG4105CXY transporter HBA75_03130 ENOG41067TZ transcriptional regulator, MarR family HBA75_03135 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_03140 ENOG4105ETE Transcriptional regulator (LacI family HBA75_03145 ENOG4108RVA ribokinase HBA75_03155 ENOG4105C2J ABC transporter HBA75_03160 ENOG4105CNN ABC, transporter HBA75_03165 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HBA75_03220 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) HBA75_03250 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HBA75_03255 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HBA75_03260 ENOG41069ER domain protein HBA75_03265 ENOG4105VZ8 Transcriptional regulator HBA75_03270 ENOG4107D63 HBA75_03285 ENOG4105DUX Transporter HBA75_03305 ENOG4105C85 amino acid HBA75_03310 ENOG4105C7N Xanthine uracil vitamin C permease HBA75_03325 ENOG4105MA6 gCN5-related N-acetyltransferase HBA75_03345 ENOG4105CCU oxidase (Subunit III) HBA75_03350 ENOG4105BZ9 Cytochrome C oxidase, subunit I HBA75_03355 ENOG4105E2S oxidase) subunit II HBA75_03375 ENOG4106CAD Protein of unknown function (DUF3311) HBA75_03380 ENOG4105E1V na solute symporter HBA75_03395 ENOG4108NHD germination protein HBA75_03405 ENOG4105CE1 Ferrous iron transport protein b HBA75_03410 ENOG4105CE1 Ferrous iron transport protein b HBA75_03415 ENOG4105CE1 Ferrous iron transport protein b HBA75_03420 ENOG4105CVA phosphate HBA75_03425 ENOG4105C8U phosphate abc transporter HBA75_03430 ENOG4105E2Z phosphate ABC transporter (Permease HBA75_03560 ENOG41080XQ Signal transduction protein with cbs domains HBA75_03580 ENOG4105ETU transcriptional activator (TenA HBA75_03590 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HBA75_03600 ENOG4108VEU Thiamine monophosphate synthase HBA75_03605 ENOG41080HI glycine oxidase HBA75_03620 ENOG4105D06 uba thif-type nad fad binding protein HBA75_03625 ENOG4105DWF phosphomethylpyrimidine kinase HBA75_03675 ENOG4108INS Transcriptional regulator HBA75_03685 ENOG4105C7N Xanthine uracil vitamin C permease HBA75_03695 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HBA75_03715 ENOG4105C5Y PTS System HBA75_03730 ENOG4105K63 Thioredoxin HBA75_03750 ENOG4108B31 Spore germination protein HBA75_03775 ENOG4107Y03 Nitroreductase HBA75_03780 ENOG4105ED1 spovr family HBA75_03805 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HBA75_03810 ENOG4105XTG Pfam:DUF156 HBA75_03815 ENOG4105VFE sira family HBA75_03820 ENOG4107TPS domain protein HBA75_03825 ENOG4105VFE sira family HBA75_03830 ENOG4105VFE sira family HBA75_03835 ENOG41085GJ domain protein HBA75_03840 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HBA75_03845 ENOG41087NI Sulfite exporter TauE/SafE HBA75_03855 ENOG4108KGH TRANSCRIPTIONal HBA75_03880 ENOG4105EMD TRANSCRIPTIONal HBA75_03885 ENOG4105VCP PTS System HBA75_03890 ENOG4105VZJ PTS System HBA75_03910 ENOG41069ER domain protein HBA75_03915 ENOG4107RBB ABC transporter, permease HBA75_03920 ENOG4105C19 ABC transporter HBA75_03950 ENOG4105WEF catalase HBA75_03985 ENOG4107T5V SNARE associated Golgi HBA75_04020 ENOG4105CUB amino acid HBA75_04025 ENOG4107RWR Sodium hydrogen exchanger HBA75_04035 ENOG4106KNT transcriptional regulator HBA75_04075 ENOG4108YXU transcriptional regulator AsnC family HBA75_04080 ENOG4105CH7 arginosuccinase HBA75_04130 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HBA75_04135 ENOG4105E5W Transporter HBA75_04150 ENOG4107RKG DJ-1/PfpI family HBA75_04155 ENOG4105CH6 catalase HBA75_04165 ENOG4105D5Q Arginine ornithine antiporter HBA75_04170 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HBA75_04180 ENOG4105C26 Dehydrogenase HBA75_04185 ENOG4105BZ1 (ABC) transporter HBA75_04190 ENOG4105BZ1 (ABC) transporter HBA75_04200 ENOG4105DRP amino acid AbC transporter HBA75_04205 ENOG4105CDA abc transporter atp-binding protein HBA75_04220 ENOG410839P HBA75_04260 ENOG4107FQX Alpha-acetolactate decarboxylase HBA75_04280 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_04285 ENOG4105D4P Coproporphyrinogen iii oxidase HBA75_04290 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_04305 ENOG4105CHH sulfate transporter HBA75_04335 ENOG4105CGU Enoyl-CoA hydratase HBA75_04355 ENOG4105DER m42 family HBA75_04375 ENOG4105CTU Proline racemase HBA75_04380 ENOG4105CIF Ornithine Cyclodeaminase HBA75_04395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HBA75_04405 ENOG4108JQ7 (ABC) transporter HBA75_04495 ENOG4108IBT Inherit from COG: transposase HBA75_04545 ENOG4105CSH Transporter HBA75_04555 ENOG4108MRH transcriptional regulatory protein HBA75_04650 ENOG4105CDU Replicative dna helicase HBA75_04675 ENOG41085W3 Transposase HBA75_04690 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_04720 ENOG4105F6J Alpha beta hydrolase fold HBA75_04765 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_04780 ENOG4105CMT Dihydroxyacetone kinase HBA75_04790 ENOG4105CMT Dihydroxyacetone kinase HBA75_04825 ENOG41069ER domain protein HBA75_04860 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HBA75_04900 ENOG4105WN5 stage II sporulation protein HBA75_04910 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_04920 ENOG4108MJI response regulator HBA75_04925 ENOG4105BZU Histidine kinase HBA75_04930 ENOG4105BZU Histidine kinase HBA75_04970 ENOG4107QHE Choloylglycine hydrolase HBA75_04990 ENOG4107VRP DNA repair exonuclease HBA75_04995 ENOG4106D4I domain protein HBA75_05010 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBA75_05065 ENOG4108MUZ hydrolase HBA75_05095 ENOG4105F0F Oxalate decarboxylase HBA75_05105 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HBA75_05125 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HBA75_05155 ENOG4105EEM helicase HBA75_05165 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_05190 ENOG4105K59 histidine triad (HIT) protein HBA75_05225 ENOG410905X membrane-flanked domain protein HBA75_05230 ENOG4105CKV Membrane HBA75_05275 ENOG410905X membrane-flanked domain protein HBA75_05280 ENOG4105CKV Membrane HBA75_05285 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HBA75_05290 ENOG4105BZ4 penicillin-binding protein HBA75_05300 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HBA75_05305 ENOG4105C1Q protoporphyrinogen oxidase HBA75_05330 ENOG4105NA0 Transcriptional regulator HBA75_05345 ENOG4105ECB domain protein HBA75_05390 ENOG4106AXD HBA75_05395 ENOG4108RQ5 Beta-lactamase domain-containing protein HBA75_05400 ENOG4105DF9 Lipoate-protein, ligase HBA75_05410 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_05420 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HBA75_05425 ENOG4108I5D sulfate abc transporter HBA75_05430 ENOG4105ECW sulfate abc transporter HBA75_05435 ENOG4108IJ6 ABC transporter HBA75_05440 ENOG4105CNA YD repeat protein HBA75_05475 ENOG4107RN3 metallophosphoesterase HBA75_05480 ENOG4107TVP HD domain protein HBA75_05490 ENOG4108AEY RNA polymerase sigma factor HBA75_05495 ENOG41086D8 Transcriptional regulator HBA75_05500 ENOG41085W3 Transposase HBA75_05515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_05535 ENOG410836F Transposase HBA75_05540 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HBA75_05545 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_05550 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HBA75_05560 ENOG4107QP3 malate synthase g HBA75_05625 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HBA75_05670 ENOG4105ERH Fumarylacetoacetate hydrolase HBA75_05680 ENOG4105C8Y Acetylornithine aminotransferase HBA75_05695 ENOG4105CAQ asparagine synthetase HBA75_05700 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HBA75_05705 ENOG4105CH6 catalase HBA75_05710 ENOG4105BZU Histidine kinase HBA75_05730 ENOG4105QNR S1 RNA binding domain protein HBA75_05735 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_05745 ENOG4107AYK membrAne HBA75_05755 ENOG41073B9 HBA75_05765 ENOG4108KP7 hydrolase HBA75_05775 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HBA75_05800 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HBA75_05805 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HBA75_05825 ENOG4105C31 Tryptophanyl-tRNA synthetase HBA75_05850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HBA75_05855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HBA75_05865 ENOG4108JQ7 (ABC) transporter HBA75_05870 ENOG4105UQX Mate efflux family protein HBA75_05890 ENOG4108ZCF integral membrane protein HBA75_05900 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HBA75_05910 ENOG4105DPN Oligoendopeptidase f HBA75_05925 ENOG4108Z18 K06886 hemoglobin HBA75_05930 ENOG4105MIX Adenylate cyclase HBA75_05945 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HBA75_05950 ENOG4105EMS pseudouridine synthase HBA75_05970 ENOG4105K64 Glycosyl transferase, family 2 HBA75_05990 ENOG4107TVC Glycosyl transferase, family 2 HBA75_06010 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HBA75_06015 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HBA75_06025 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HBA75_06105 ENOG4105CK7 Sodium proline symporter HBA75_06115 ENOG4105DDQ anthranilate synthase HBA75_06205 ENOG4105C7S Dehydrogenase HBA75_06210 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HBA75_06215 ENOG4105VZ8 Transcriptional regulator HBA75_06275 ENOG4105DZ1 carboxypeptidase HBA75_06280 ENOG4105VFR signal peptidase HBA75_06315 ENOG4105C26 Dehydrogenase HBA75_06320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HBA75_06325 ENOG4105F38 ABC transporter, permease HBA75_06330 ENOG4105D38 putrescine abc transporter HBA75_06335 ENOG4108HM4 ABC transporter HBA75_06345 ENOG4105EYF MMPL domain protein HBA75_06355 ENOG4108YBP pseudouridine synthase HBA75_06365 ENOG4105K4I Scp-like extracellular HBA75_06370 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HBA75_06375 ENOG4105CQB FAD linked oxidase domain protein HBA75_06390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_06395 ENOG4105BZU Histidine kinase HBA75_06400 ENOG4105JXH GntR family transcriptional regulator HBA75_06420 ENOG4106A3R peptidase HBA75_06425 ENOG4108QTI )-transporter HBA75_06430 ENOG4107TS3 membrane protein, TerC HBA75_06435 ENOG4105CZN Potassium uptake protein HBA75_06440 ENOG410681C small acid-soluble spore protein HBA75_06445 ENOG4108Z7G MaoC domain protein dehydratase HBA75_06465 ENOG4105CHR reductase HBA75_06495 ENOG4105C4Y ABC transporter HBA75_06500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HBA75_06505 ENOG4107RCV ABC transporter, permease HBA75_06525 ENOG4105E98 transcriptional regulator DeoR family HBA75_06535 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HBA75_06545 ENOG4105PXI polysaccharide deacetylase HBA75_06555 ENOG4105BZU Histidine kinase HBA75_06560 ENOG41090MY MarR family Transcriptional regulator HBA75_06570 ENOG4106DF1 HBA75_06575 ENOG4105BZU Histidine kinase HBA75_06580 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HBA75_06585 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HBA75_06590 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HBA75_06630 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HBA75_06635 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HBA75_06640 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HBA75_06645 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HBA75_06650 ENOG4105CZV ABC transporter HBA75_06660 ENOG4105CJ1 ABC, transporter HBA75_06700 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HBA75_06705 ENOG4105EA8 2-Nitropropane dioxygenase HBA75_06710 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HBA75_06720 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HBA75_06745 ENOG4105NQC Flavodoxin HBA75_06785 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HBA75_06815 ENOG4105CZN Potassium uptake protein HBA75_06820 ENOG41063Y9 HBA75_06825 ENOG4105KBJ sporulation protein ytfj HBA75_06845 ENOG4105CM2 brancheD-chain amino acid aminotransferase HBA75_06850 ENOG4105C7K acetolactate synthase HBA75_06855 ENOG4108ZP8 Acetolactate synthase small subunit HBA75_06860 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HBA75_06875 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HBA75_06895 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HBA75_06900 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HBA75_06925 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase HBA75_06930 ENOG4107RVV histidinol phosphate phosphatase, hisj family HBA75_06945 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_06950 ENOG4105E0M Sulfatase HBA75_06960 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HBA75_06975 ENOG4107S4M Sulfate adenylate transferase HBA75_06980 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HBA75_06985 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HBA75_06995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HBA75_07000 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HBA75_07005 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HBA75_07010 ENOG4105C8J )-transporter HBA75_07035 ENOG4105DFD Na H antiporter HBA75_07055 ENOG4105ENE Histidine kinase HBA75_07060 ENOG4105WH1 Two component transcriptional regulator luxr family HBA75_07080 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HBA75_07120 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HBA75_07145 ENOG4105CJ3 phosphate transporter HBA75_07150 ENOG4107GRR phosphate transport regulator HBA75_07155 ENOG4105BZ4 penicillin-binding protein HBA75_07170 ENOG4105BZU Histidine kinase HBA75_07175 ENOG4105I3N Conserved Protein HBA75_07190 ENOG4105BZU Histidine kinase HBA75_07220 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBA75_07225 ENOG4105DZ1 carboxypeptidase HBA75_07230 ENOG4108JIC nucleoside recognition domain protein HBA75_07240 ENOG4105FE9 pseudouridine synthase HBA75_07245 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_07250 ENOG4107TWT Cytochrome c biogenesis protein HBA75_07255 ENOG4105CRE cytochrome C HBA75_07260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_07265 ENOG4105BZU Histidine kinase HBA75_07270 ENOG4108WBT adenosyltransferase HBA75_07290 ENOG4108SAX Membrane HBA75_07305 ENOG4105C9U ATP-dependent DNA helicase RecQ HBA75_07310 ENOG4105I7S Abortive infection protein HBA75_07325 ENOG4108XDN Transcriptional regulator HBA75_07330 ENOG4108S6Z Negative regulator of genetic competence HBA75_07355 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HBA75_07360 ENOG4107RB3 L-asparaginase HBA75_07380 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HBA75_07395 ENOG4105S2F HBA75_07400 ENOG41065D1 HBA75_07430 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HBA75_07445 ENOG4105XXQ heptaprenyl diphosphate synthase component I HBA75_07455 ENOG4105EAH synthase HBA75_07460 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HBA75_07470 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HBA75_07485 ENOG41068YB TPR repeat-containing protein HBA75_07500 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) HBA75_07505 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HBA75_07540 ENOG4108JYZ YitT family HBA75_07545 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HBA75_07560 ENOG4105FJR Lmbe family HBA75_07565 ENOG4105CPK Glycosyl transferase (Group 1 HBA75_07585 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HBA75_07600 ENOG4105DVT helicase HBA75_07605 ENOG4105YAC HBA75_07625 ENOG4105CSM endonuclease III HBA75_07635 ENOG4105BZ4 penicillin-binding protein HBA75_07690 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HBA75_07730 ENOG4105DVT helicase HBA75_07735 ENOG4105CTD carboxy-peptidase HBA75_07745 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HBA75_07755 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HBA75_07760 ENOG4105C2W permease HBA75_07765 ENOG4105DHF Membrane HBA75_07775 ENOG410890F Dynamin family HBA75_07785 ENOG4108W0I acetyltransferase HBA75_07795 ENOG4105KHC sulfurtransferase HBA75_07820 ENOG4106032 Glutathionylspermidine synthase HBA75_07850 ENOG4105HTX biosynthesis protein HBA75_07880 ENOG4105CPK Glycosyl transferase (Group 1 HBA75_07895 ENOG4108SZE gCN5-related N-acetyltransferase HBA75_07915 ENOG41081VK Ribonuclease HBA75_07990 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HBA75_08000 ENOG4107RWR Sodium hydrogen exchanger HBA75_08005 ENOG4105CN5 Metallo-Beta-Lactamase HBA75_08010 ENOG4108Z5V transcriptional regulator, merr family HBA75_08020 ENOG4105H67 Protein of unknown function (DUF421) HBA75_08025 ENOG41080C8 DUF218 domain HBA75_08065 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HBA75_08075 ENOG4107R0U MotA TolQ exbB proton channel HBA75_08080 ENOG4105ER2 Ompa motb domain protein HBA75_08085 ENOG4107YTP response regulator receiver protein HBA75_08090 ENOG4105CBS Chea signal transduction histidine kinase HBA75_08095 ENOG4105DD5 Flagellar motor switch protein HBA75_08110 ENOG4105BZU Histidine kinase HBA75_08130 ENOG4105E1Q flagellar hook-associated protein HBA75_08135 ENOG4105DTJ flagellar hook-associated protein HBA75_08140 ENOG4107TPX flagellar hook-associated HBA75_08155 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HBA75_08160 ENOG4108ZC9 flagellar basal-body rod protein flgc HBA75_08170 ENOG4107U2N Flagellar M-ring protein HBA75_08175 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HBA75_08205 ENOG4105BZE flagellar hook protein, FlgE HBA75_08220 ENOG4107R88 Chemotaxis protein (CheV) HBA75_08230 ENOG4105I03 Flagellin HBA75_08235 ENOG4105I03 Flagellin HBA75_08240 ENOG4105I03 Flagellin HBA75_08245 ENOG4105I03 Flagellin HBA75_08250 ENOG4105E4C Lytic transglycosylase catalytic HBA75_08260 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HBA75_08265 ENOG4105DD5 Flagellar motor switch protein HBA75_08275 ENOG4105CN7 Flagellar biosynthetic protein FliP HBA75_08280 ENOG4105VS8 Flagellar biosynthetic protein fliq HBA75_08290 ENOG4105D00 flagellar biosynthetic protein flhB HBA75_08295 ENOG4105D7B Flagellar biosynthesis protein flha HBA75_08300 ENOG4105FZW flagellar biosynthesis regulator FlhF HBA75_08305 ENOG4105KTQ flagellar basal-body rod protein HBA75_08310 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HBA75_08355 ENOG4105KAC Antibiotic biosynthesis monooxygenase HBA75_08395 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component HBA75_08400 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HBA75_08435 ENOG4105CVJ phosphoglycerate mutase HBA75_08445 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HBA75_08465 ENOG4105CAQ asparagine synthetase HBA75_08485 ENOG4105PGM cation diffusion facilitator family transporter HBA75_08495 ENOG4105DRR Transcriptional regulator, GntR family HBA75_08500 ENOG4108UZ3 Transporter HBA75_08510 ENOG4105CKI cobalamin synthesis protein HBA75_08515 ENOG4108PJD permease HBA75_08530 ENOG4105DFD Na H antiporter HBA75_08535 ENOG4105VUF Transcriptional regulator HBA75_08545 ENOG4105C9Q fumarate hydratase class II HBA75_08565 ENOG4107QJQ Mate efflux family protein HBA75_08570 ENOG4105EC3 peptidase S51, dipeptidase E HBA75_08590 ENOG4107QIV Cytochrome c biogenesis protein HBA75_08595 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_08615 ENOG4106BRA Membrane HBA75_08650 ENOG4105CJ1 ABC, transporter HBA75_08675 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HBA75_08685 ENOG4108IJ0 Aspartate ammonia-lyase HBA75_08690 ENOG4105DQ6 Transposase HBA75_08705 ENOG4105C6K Malic enzyme HBA75_08760 ENOG4105FVX HBA75_08765 ENOG4105E09 nadh pyrophosphatase HBA75_08780 ENOG4105CSR polyphosphate kinase 2 HBA75_08785 ENOG4105U3E Transcriptional regulator HBA75_08800 ENOG4105DXI Major Facilitator superfamily HBA75_08815 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HBA75_08835 ENOG4105C6T cysteine synthase HBA75_08855 ENOG4105C8J )-transporter HBA75_08865 ENOG4105X5K response regulator receiver protein HBA75_08870 ENOG4105H67 Protein of unknown function (DUF421) HBA75_08890 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HBA75_08895 ENOG4105CHR reductase HBA75_08900 ENOG4105CM2 brancheD-chain amino acid aminotransferase HBA75_08905 ENOG4105C7K acetolactate synthase HBA75_08915 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HBA75_08925 ENOG4105C7B Threonine dehydratase HBA75_08945 ENOG4105C6X Major Facilitator HBA75_08950 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HBA75_08960 ENOG4105DY9 regulatoR HBA75_08965 ENOG4105CYC Transferase HBA75_08970 ENOG4105K5X acetyltransferase HBA75_08990 ENOG41068WN HBA75_09010 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HBA75_09025 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HBA75_09030 ENOG4105C0X amino acid HBA75_09075 ENOG410849A acetyltransferase, (GNAT) family HBA75_09135 ENOG4107RHR regulatoR HBA75_09145 ENOG4105D9N nucleoside HBA75_09150 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HBA75_09180 ENOG410811B TRANSCRIPTIONal HBA75_09195 ENOG4107RAQ aminopeptidase HBA75_09205 ENOG4107R16 Multicopper oxidase HBA75_09220 ENOG4105MKU Transcriptional regulator HBA75_09280 ENOG4105W8Z 4'-phosphopantetheinyl transferase HBA75_09320 ENOG4108T5E Copper resistance protein HBA75_09325 ENOG4105KTB nuclear export factor GLE1 HBA75_09345 ENOG4105GZI Transcriptional regulator HBA75_09350 ENOG4108Z40 Transcriptional regulator HBA75_09360 ENOG4108TVJ Nitroreductase HBA75_09370 ENOG4106F5Q Membrane HBA75_09375 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HBA75_09385 ENOG4105CKI cobalamin synthesis protein HBA75_09395 ENOG4105C0Z ABC transporter HBA75_09400 ENOG4108IV0 ABC, transporter HBA75_09405 ENOG4105C32 Amino acid ABC transporter (Permease) HBA75_09415 ENOG4105SKE transcriptional Regulator LysR family HBA75_09445 ENOG4105C4M (Ubiquinol oxidase) subunit I HBA75_09450 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HBA75_09460 ENOG4108JJ8 (ABC) transporter HBA75_09470 ENOG4105K64 Glycosyl transferase, family 2 HBA75_09480 ENOG4108UT6 Transferase hexapeptide repeat containing protein HBA75_09535 ENOG4105BZ1 (ABC) transporter HBA75_09540 ENOG4105EFI regulatoR HBA75_09545 ENOG4105BZU Histidine kinase HBA75_09560 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HBA75_09585 ENOG41085W3 Transposase HBA75_09590 ENOG4105D6E homoserine dehydrogenase HBA75_09615 ENOG4108KGH TRANSCRIPTIONal HBA75_09625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_09630 ENOG4105BZU Histidine kinase HBA75_09645 ENOG4105KT7 mgtC SapB transporter HBA75_09650 ENOG4105VRR gCN5-related N-acetyltransferase HBA75_09660 ENOG4105DUU IucA IucC family protein HBA75_09665 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_09680 ENOG4108WBH protein TIM barrel HBA75_09685 ENOG4105YWU small acid-soluble spore protein HBA75_09695 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HBA75_09700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_09755 ENOG4105KRN Transcriptional regulator, abrb family HBA75_09765 ENOG4105YVS arsR family transcriptional regulator HBA75_09770 ENOG4105CPC Aldo Keto reductase HBA75_09775 ENOG4107XZQ multidrug resistance protein HBA75_09800 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_09815 ENOG4108K88 Membrane HBA75_09820 ENOG4108WPJ Ferritin-like domain HBA75_09835 ENOG4105DEN Luciferase family HBA75_09850 ENOG4105VMI -acetyltransferase HBA75_09855 ENOG4107QM2 Aldo Keto reductase HBA75_09865 ENOG4105CKI cobalamin synthesis protein HBA75_09875 ENOG4105DSE periplasmic solute binding protein HBA75_09890 ENOG4105K4T epimerase HBA75_09900 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HBA75_09945 ENOG4107T5V SNARE associated Golgi HBA75_09960 ENOG4108PJD permease HBA75_09970 ENOG4108S4H thioesterase Superfamily protein HBA75_09980 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HBA75_10000 ENOG4105SXS Protein of unknown function (DUF456) HBA75_10005 ENOG4105C37 (CBS) domain HBA75_10025 ENOG4108Z7R Chaperone CsaA HBA75_10045 ENOG4108ZRV stage ii sporulation protein p HBA75_10055 ENOG4108VXD carboxy-peptidase HBA75_10080 ENOG4108ZRV stage ii sporulation protein p HBA75_10090 ENOG4108X4Q Hydrolase HBA75_10105 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HBA75_10120 ENOG41087PP glycosyltransferase MGT family HBA75_10125 ENOG4108JYZ YitT family HBA75_10130 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_10160 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HBA75_10195 ENOG4108MGT Required for secretion of EsxA and EsxB HBA75_10275 ENOG4105KBJ sporulation protein ytfj HBA75_10280 ENOG4105DQ6 Transposase HBA75_10310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HBA75_10330 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HBA75_10335 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HBA75_10345 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HBA75_10365 ENOG4105CNW domain protein HBA75_10375 ENOG4108V06 Glutathione peroxidase HBA75_10390 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HBA75_10400 ENOG4108IUE nitrate reductase beta subunit HBA75_10405 ENOG4105R3A Nitrate reductase HBA75_10415 ENOG4107V6Q Cyclic nucleotide-binding domain HBA75_10420 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBA75_10425 ENOG4105D06 uba thif-type nad fad binding protein HBA75_10430 ENOG4105CVM Molybdenum cofactor synthesis domain protein HBA75_10435 ENOG4108ZAF Molybdopterin HBA75_10465 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HBA75_10470 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HBA75_10475 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HBA75_10480 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HBA75_10485 ENOG4108IFG nitrite reductase, (NAD(P)H) HBA75_10540 ENOG4105MCT stage V sporulation protein S HBA75_10585 ENOG4105C5H ABC transporter HBA75_10600 ENOG4108UUM single-stranded DNA-binding protein HBA75_10635 ENOG4107YX5 Pfam:DUF548 HBA75_10640 ENOG4105C75 arginyL-tRNA synthetase HBA75_10665 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HBA75_10675 ENOG410836F Transposase HBA75_10700 ENOG4105C5S asparaginyl-tRNA synthetase HBA75_10705 ENOG4105C8J )-transporter HBA75_10725 ENOG4107XGZ Hydrolase HBA75_10730 ENOG4105CY2 Citrate transporter HBA75_10750 ENOG4105KD7 acetyltransferase HBA75_10760 ENOG4105VMP Transcriptional regulator HBA75_10765 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HBA75_10790 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 HBA75_10805 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) HBA75_10810 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HBA75_10820 ENOG4107RVG penicillin-binding protein HBA75_10825 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HBA75_10830 ENOG4105E9Q Acyl-transferase HBA75_10835 ENOG4108UT2 hemolysin iii HBA75_10845 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HBA75_10855 ENOG4108RCR degv family HBA75_10865 ENOG4108KF3 Electron transport protein SCO1 SenC HBA75_10870 ENOG4107Y70 Heat shock protein HBA75_10875 ENOG4105CAQ asparagine synthetase HBA75_10895 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HBA75_10900 ENOG4108MES Periplasmic binding protein HBA75_10905 ENOG4105F0I Aminotransferase HBA75_10950 ENOG4105D8X mechanosensitive ion channel HBA75_10955 ENOG4105BZU Histidine kinase HBA75_10960 ENOG4105WH1 Two component transcriptional regulator luxr family HBA75_10965 ENOG4106KNT transcriptional regulator HBA75_11000 ENOG4105CMG Carbohydrate kinase HBA75_11005 ENOG4105C6Z Gluconate HBA75_11015 ENOG4108YV3 Protein of unknown function (DUF2711) HBA75_11045 ENOG4108IJ8 ABC transporter HBA75_11050 ENOG4105E90 ABC transporter HBA75_11085 ENOG4105C37 (CBS) domain HBA75_11110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HBA75_11125 ENOG4107S4Y M20 DapE family protein YgeY HBA75_11130 ENOG4108TSC N-acetyltransferase HBA75_11135 ENOG4108JUB Transcriptional regulator HBA75_11145 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HBA75_11190 ENOG410841Q phosphoesterase PA-phosphatase related protein HBA75_11200 ENOG4105SZ6 Thioredoxin HBA75_11245 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_11300 ENOG4105BZ4 penicillin-binding protein HBA75_11310 ENOG4105CZM Major Facilitator HBA75_11315 ENOG4105W8X HesB YadR YfhF-family protein HBA75_11325 ENOG4105DXD 2-methylcitrate dehydratase HBA75_11330 ENOG4105CR4 methylisocitrate lyase HBA75_11335 ENOG4105C1G acyl-Coa dehydrogenase HBA75_11340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HBA75_11350 ENOG4105N14 lysine exporter protein LysE YggA HBA75_11355 ENOG4105E39 Enoyl-CoA hydratase HBA75_11370 ENOG4107RFY SbcCD D subunit HBA75_11375 ENOG4105EYH Exonuclease HBA75_11405 ENOG4105FCD Major Facilitator HBA75_11410 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HBA75_11415 ENOG4105E4F Isochorismate synthase HBA75_11420 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HBA75_11425 ENOG4105WQI isochorismatase HBA75_11430 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_11435 ENOG4105WQT MbtH domain protein HBA75_11440 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_11455 ENOG4105K70 DNA-binding protein HBA75_11475 ENOG4105BZG amino acid carrier protein HBA75_11495 ENOG4105FE9 pseudouridine synthase HBA75_11500 ENOG4105C22 threonyL-tRNA synthetase HBA75_11505 ENOG4105C19 ABC transporter HBA75_11565 ENOG41081I9 integral membrane protein HBA75_11575 ENOG4108Y4K DNA-binding transcriptional activator HBA75_11595 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HBA75_11605 ENOG4105EYF MMPL domain protein HBA75_11630 ENOG4105WCN acetyltransferase HBA75_11655 ENOG4105C1Q protoporphyrinogen oxidase HBA75_11665 ENOG41068WN HBA75_11695 ENOG4107V2S Transcriptional regulator HBA75_11700 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HBA75_11720 ENOG4105DND Transcriptional regulator HBA75_11725 ENOG4108RPX mosc domain containing protein HBA75_11740 ENOG4105BZ1 (ABC) transporter HBA75_11775 ENOG4108JCI Transcriptional regulator HBA75_11805 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HBA75_11810 ENOG4108KPJ rna polymerase sigma factor HBA75_11835 ENOG4105F32 YngK protein HBA75_11855 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HBA75_11860 ENOG4105RD7 BadF BadG BcrA BcrD HBA75_11865 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HBA75_11870 ENOG4107STF Involved in phosphonate degradation (By similarity) HBA75_11880 ENOG4108INS Transcriptional regulator HBA75_11895 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HBA75_11905 ENOG4105C1J atp-dependent rna helicase HBA75_11925 ENOG4105KRN Transcriptional regulator, abrb family HBA75_11995 ENOG41088CC tellurite resistance protein tehB HBA75_12005 ENOG4108I0C methyltransferase HBA75_12010 ENOG4107RA9 decarboxylase HBA75_12015 ENOG41090HR transcriptional regulator HBA75_12020 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HBA75_12045 ENOG4105CIN aminoacyl-histidine dipeptidase HBA75_12075 ENOG4105KRN Transcriptional regulator, abrb family HBA75_12090 ENOG4105EJ9 Membrane HBA75_12095 ENOG4105EQK -acetyltransferase HBA75_12135 ENOG41085W3 Transposase HBA75_12150 ENOG4105W8Z 4'-phosphopantetheinyl transferase HBA75_12195 ENOG4105EKQ RNA-directed DNA polymerase HBA75_12280 ENOG4105FQP Beta-lactamase HBA75_12285 ENOG4107RVG penicillin-binding protein HBA75_12300 ENOG4107RF6 penicillin-binding protein HBA75_12305 ENOG4107RF6 penicillin-binding protein HBA75_12315 ENOG4105DIN metallophosphoesterase HBA75_12325 ENOG4105CJ1 ABC, transporter HBA75_12335 ENOG4107Z3H Transcriptional regulator, TetR family HBA75_12350 ENOG4105C1G acyl-Coa dehydrogenase HBA75_12355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HBA75_12360 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HBA75_12365 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HBA75_12370 ENOG4105E39 Enoyl-CoA hydratase HBA75_12375 ENOG4107QX3 carboxylase HBA75_12380 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HBA75_12390 ENOG41085W3 Transposase HBA75_12405 ENOG4105DBI uridine monophosphokinase HBA75_12420 ENOG4105DZ1 carboxypeptidase HBA75_12445 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HBA75_12465 ENOG41075H3 AraC family transcriptional regulator HBA75_12510 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HBA75_12550 ENOG4107Y80 Major Facilitator superfamily HBA75_12555 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HBA75_12560 ENOG4105KVH Transcriptional regulator HBA75_12625 ENOG4105EFA 4-hydroxyphenylacetate HBA75_12640 ENOG4105CPQ Dehydrogenase HBA75_12650 ENOG410900G Protein of unknown function (DUF421) HBA75_12665 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HBA75_12675 ENOG4105DK7 lysyl-tRNA synthetase HBA75_12685 ENOG4108VQT Alpha beta hydrolase fold protein HBA75_12785 ENOG4105CPF Cell wall formation (By similarity) HBA75_12790 ENOG4105ETU transcriptional activator (TenA HBA75_12885 ENOG410667J hydrolase HBA75_12890 ENOG4105BZU Histidine kinase HBA75_12895 ENOG4107RF6 penicillin-binding protein HBA75_12920 ENOG4108JJB ABC transporter HBA75_12935 ENOG4108HGU Histidine kinase HBA75_12950 ENOG4105CB2 alcohol dehydrogenase HBA75_12955 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HBA75_12960 ENOG4105CJN penicillin-binding protein HBA75_13020 ENOG4107STQ Multicopper oxidase HBA75_13030 ENOG4107TXC Transcriptional regulator HBA75_13050 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HBA75_13070 ENOG4105DQ6 Transposase HBA75_13090 ENOG4107Y9U Membrane HBA75_13135 ENOG4105FCD Major Facilitator HBA75_13145 ENOG4105E09 nadh pyrophosphatase HBA75_13150 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HBA75_13170 ENOG4108XI2 Domain of unknown function (DUF1963) HBA75_13190 ENOG4108NRW Phospholipase, patatin family HBA75_13195 ENOG4105KWG Pfam:DUF1696 HBA75_13220 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HBA75_13230 ENOG4105PKS Excinuclease abc c subunit domain protein HBA75_13280 ENOG4107VFR oxidoreductase HBA75_13320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_13325 ENOG4105BZU Histidine kinase HBA75_13345 ENOG4107WD8 ABC transporter, permease HBA75_13360 ENOG4105DQ6 Transposase HBA75_13380 ENOG4105DY8 decarboxylase HBA75_13405 ENOG4105CGH 5'-nucleotidase HBA75_13420 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HBA75_13425 ENOG4105FDR Membrane HBA75_13485 ENOG4105MSI germination protein ypeb HBA75_13535 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) HBA75_13540 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) HBA75_13545 ENOG4107Z3H Transcriptional regulator, TetR family HBA75_13570 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HBA75_13590 ENOG4105E98 transcriptional regulator DeoR family HBA75_13605 ENOG41062ES Transcriptional regulator HBA75_13625 ENOG4107QKR Dehydrogenase HBA75_13635 ENOG4107RUY (E1 component), alpha subunit HBA75_13645 ENOG4105E1F short-chain dehydrogenase reductase HBA75_13650 ENOG4105RHY Pfam:UPF0157 HBA75_13690 ENOG4107SQ8 Glycine betaine HBA75_13695 ENOG4108IJ7 Glycine betaine HBA75_13705 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HBA75_13720 ENOG4105E66 phosphoriboisomerase A HBA75_13725 ENOG41082BV acetyltransferase HBA75_13730 ENOG4108M1A Chitin-binding protein HBA75_13760 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_13765 ENOG4105MSB protein, conserved in bacteria HBA75_13790 ENOG4108Z7F N-acetyltransferase HBA75_13810 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HBA75_13815 ENOG4105EEM helicase HBA75_13830 ENOG4105C9U ATP-dependent DNA helicase RecQ HBA75_13870 ENOG4105DQ6 Transposase HBA75_13900 ENOG4108M1A Chitin-binding protein HBA75_13915 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HBA75_13925 ENOG4105BZG amino acid carrier protein HBA75_13930 ENOG4105C26 Dehydrogenase HBA75_13935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBA75_13940 ENOG4105CTU Proline racemase HBA75_13945 ENOG4105CTU Proline racemase HBA75_13950 ENOG41080HI glycine oxidase HBA75_13960 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein HBA75_13995 ENOG4107T5V SNARE associated Golgi HBA75_14005 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HBA75_14030 ENOG4105DTQ mandelate racemase muconate lactonizing HBA75_14045 ENOG4107SET aldo keto reductase HBA75_14080 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) HBA75_14085 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HBA75_14090 ENOG4105BZU Histidine kinase HBA75_14095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_14115 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HBA75_14130 ENOG4105DPN Oligoendopeptidase f HBA75_14135 ENOG4105EPR degv family HBA75_14195 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HBA75_14200 ENOG4106K7D Major facilitator family transporter HBA75_14220 ENOG4107BMA Transglycosylase associated protein HBA75_14235 ENOG41089UC methyltransferase, type 11 HBA75_14270 ENOG4105CHM Aminotransferase HBA75_14285 ENOG4108ZMI UPF0477 protein HBA75_14325 ENOG4105C02 permease HBA75_14335 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HBA75_14340 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HBA75_14345 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HBA75_14350 ENOG4105D7T ABC transporter HBA75_14385 ENOG4108AQF aminoglycoside N(3)-acetyltransferase HBA75_14430 ENOG4107VC0 DNA alkylation repair enzyme HBA75_14435 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_14455 ENOG4108ZCF integral membrane protein HBA75_14460 ENOG4105E0M Sulfatase HBA75_14465 ENOG4105C5H ABC transporter HBA75_14470 ENOG4105EYF MMPL domain protein HBA75_14475 ENOG41082JN Transcriptional regulator HBA75_14485 ENOG410836F Transposase HBA75_14505 ENOG4105CIH Imidazole acetol-phosphate transaminase HBA75_14510 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HBA75_14515 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HBA75_14535 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HBA75_14560 ENOG41069ER domain protein HBA75_14570 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_14575 ENOG4105DNP FAD linked oxidase domain protein HBA75_14605 ENOG4105D4B ABC, transporter HBA75_14610 ENOG4105F5R ABC transporter HBA75_14615 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HBA75_14625 ENOG4105DKT Transcriptional regulator HBA75_14630 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HBA75_14640 ENOG41061GT Aldolase HBA75_14650 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HBA75_14685 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_14695 ENOG4107258 Transcriptional regulator HBA75_14750 ENOG4107RBI VanW family HBA75_14755 ENOG4105G6Z alkaline phosphatase HBA75_14765 ENOG4105VMP Transcriptional regulator HBA75_14790 ENOG41068WN HBA75_14820 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HBA75_14835 ENOG4105CSH Transporter HBA75_14845 ENOG4105CKK Glycosyl transferase, family 2 HBA75_14875 ENOG4105C8Y Acetylornithine aminotransferase HBA75_14925 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HBA75_14975 ENOG4108IBT Inherit from COG: transposase HBA75_14995 ENOG4108TVJ Nitroreductase HBA75_15000 ENOG4105FS7 Transcriptional regulator HBA75_15020 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HBA75_15025 ENOG4105WEC Molybdate metabolism regulator HBA75_15035 ENOG4105CMR udp-glucose 4-epimerase HBA75_15045 ENOG4108DMH HTH_ARAC HBA75_15050 ENOG4108XET gCN5-related N-acetyltransferase HBA75_15065 ENOG4108PCN EamA-like transporter family HBA75_15110 ENOG410635A Membrane HBA75_15125 ENOG4108IQI permease HBA75_15135 ENOG4105F1N DNA alkylation repair HBA75_15165 ENOG4107RF6 penicillin-binding protein HBA75_15170 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HBA75_15190 ENOG410836F Transposase HBA75_15195 ENOG4105E7W lamb ycsf family protein HBA75_15205 ENOG4105P4J Allophanate hydrolase, subunit 1 HBA75_15210 ENOG4107258 Transcriptional regulator HBA75_15220 ENOG4106N3A copper homeostasis protein cutc HBA75_15225 ENOG4108ZHR arsR family transcriptional regulator HBA75_15240 ENOG4105FDT acyl-CoA dehydrogenase HBA75_15260 ENOG4105DQ6 Transposase HBA75_15275 ENOG4105DQ6 Transposase HBA75_15280 ENOG4105DWD nucleoside recognition domain protein HBA75_15320 ENOG4105DQ6 Transposase HBA75_15340 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HBA75_15345 ENOG41087PP glycosyltransferase MGT family HBA75_15400 ENOG4105E2A Dehydrogenase HBA75_15410 ENOG4108IJ0 Aspartate ammonia-lyase HBA75_15415 ENOG4105HDK L-asparaginase HBA75_15420 ENOG4108IMY Transcriptional regulator HBA75_15455 ENOG4108B31 Spore germination protein HBA75_15465 ENOG4105BZU Histidine kinase HBA75_15490 ENOG41075H3 AraC family transcriptional regulator HBA75_15500 ENOG4105YWU small acid-soluble spore protein HBA75_15505 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HBA75_15510 ENOG4105CUB amino acid HBA75_15515 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_15525 ENOG4105C6K Malic enzyme HBA75_15550 ENOG4108NHD germination protein HBA75_15555 ENOG4108Q8B Spore germination protein HBA75_15575 ENOG4105CSV Glutaminase HBA75_15590 ENOG4106A3M Cytochrome p-450 HBA75_15605 ENOG4108IG5 Transcriptional regulator HBA75_15610 ENOG4105F27 Major Facilitator HBA75_15615 ENOG4105M4P Tetr family transcriptional regulator HBA75_15625 ENOG4108YXU transcriptional regulator AsnC family HBA75_15665 ENOG4105N0V mono-oxygenase ydhR HBA75_15690 ENOG41085W3 Transposase HBA75_15740 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HBA75_15745 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_15755 ENOG4105K6H D-cysteine desulfhydrase HBA75_15765 ENOG4105E0Y RtcB Protein HBA75_15775 ENOG4105JQZ Methyltransferase HBA75_15800 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) HBA75_15820 ENOG4105BZU Histidine kinase HBA75_15835 ENOG4108U05 Transcriptional regulator HBA75_15840 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HBA75_15850 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HBA75_15885 ENOG4108JQ1 Dehydrogenase HBA75_15890 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HBA75_15930 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_16040 ENOG4108VXD carboxy-peptidase HBA75_16045 ENOG4105PNM synthesis protein HBA75_16055 ENOG4108ISG Major Facilitator HBA75_16070 ENOG4107MII Sugar-specific transcriptional regulator TrmB HBA75_16075 ENOG4105CZM Major Facilitator HBA75_16090 ENOG4105DA5 (ABC) transporter HBA75_16095 ENOG41069JR HBA75_16110 ENOG4105CRW Short chain fatty acid transporter HBA75_16120 ENOG4105DYS nad(p)h dehydrogenase (quinone) HBA75_16180 ENOG4108K8S endonuclease I HBA75_16190 ENOG4105CUT histidyl-tRNA synthetase HBA75_16205 ENOG4105KVH Transcriptional regulator HBA75_16210 ENOG4108RCM Nitroreductase HBA75_16220 ENOG4105CA9 Pyruvate kinase HBA75_16240 ENOG4108PSK reductase HBA75_16310 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HBA75_16345 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HBA75_16385 ENOG4105C37 (CBS) domain HBA75_16400 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HBA75_16405 ENOG4105FAW cDP-glucose 4,6-dehydratase HBA75_16435 ENOG4105DDN Pentapeptide repeat-containing protein HBA75_16440 ENOG4105XDF Protein of unknown function (DUF1272) HBA75_16445 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HBA75_16450 ENOG4105CMG Carbohydrate kinase HBA75_16455 ENOG4105C6Z Gluconate HBA75_16465 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HBA75_16475 ENOG4105CV1 Transketolase (EC 2.2.1.1) HBA75_16480 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HBA75_16485 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HBA75_16490 ENOG4105CIS alcohol dehydrogenase HBA75_16495 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HBA75_16505 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HBA75_16520 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_16525 ENOG4108UX3 '-nucleotidase HBA75_16530 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HBA75_16535 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HBA75_16540 ENOG4105KVH Transcriptional regulator HBA75_16555 ENOG4105CV8 reductase HBA75_16560 ENOG4105F27 Major Facilitator HBA75_16570 ENOG41090KN UPF0303 protein HBA75_16585 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HBA75_16590 ENOG4105CHH sulfate transporter HBA75_16605 ENOG4105C44 Serine transporter HBA75_16630 ENOG41085W3 Transposase HBA75_16645 ENOG4105KVH Transcriptional regulator HBA75_16650 ENOG4108TZY GntR Family Transcriptional Regulator HBA75_16655 ENOG4105D9R oxidoreductase HBA75_16660 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HBA75_16665 ENOG4105KVH Transcriptional regulator HBA75_16670 ENOG4105KVH Transcriptional regulator HBA75_16730 ENOG4105JAB phenazine biosynthesis protein, phzf family HBA75_16740 ENOG4105CHR reductase HBA75_16750 ENOG4105KNA -acetyltransferase HBA75_16765 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HBA75_16770 ENOG4105KVH Transcriptional regulator HBA75_16785 ENOG41085W3 Transposase HBA75_16790 ENOG4105DQ6 Transposase HBA75_16895 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HBA75_16905 ENOG4107YXZ hydrolase, family 25 HBA75_16935 ENOG4105H3G oxidoreductase HBA75_17005 ENOG4108TN2 lmbE family HBA75_17015 ENOG4107R3E Citrate transporter HBA75_17025 ENOG4105WCN acetyltransferase HBA75_17030 ENOG4108MES Periplasmic binding protein HBA75_17035 ENOG4105EHG Permease protein HBA75_17040 ENOG4105DQ5 transport system permease protein HBA75_17045 ENOG4105NX3 Membrane HBA75_17065 ENOG4105D9U N-acetyltransferase HBA75_17070 ENOG4107CUJ Protein of unknown function (DUF2690) HBA75_17080 ENOG4107V2S Transcriptional regulator HBA75_17100 ENOG4105C98 muts2 protein HBA75_17105 ENOG4105E5K Alpha-amylase HBA75_17110 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HBA75_17115 ENOG4105DPN Oligoendopeptidase f HBA75_17140 ENOG4105FFC UPF0187 protein HBA75_17155 ENOG4108A04 Beta-lactamase HBA75_17180 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HBA75_17190 ENOG41082BM Transcriptional regulator, arsr family HBA75_17195 ENOG4105CIS alcohol dehydrogenase HBA75_17200 ENOG4105CNG UPF0061 protein HBA75_17220 ENOG4105CQB FAD linked oxidase domain protein HBA75_17245 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_17250 ENOG4107TPS domain protein HBA75_17255 ENOG4105CEP NADH dehydrogenase HBA75_17265 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HBA75_17275 ENOG4108IAJ Nad-dependent epimerase dehydratase HBA75_17280 ENOG4105FAW cDP-glucose 4,6-dehydratase HBA75_17315 ENOG41067SE Tetr family transcriptional regulator HBA75_17330 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity HBA75_17340 ENOG4107DUR UPF0457 protein HBA75_17360 ENOG4105BZU Histidine kinase HBA75_17370 ENOG4105KT7 mgtC SapB transporter HBA75_17380 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_17385 ENOG41073R8 VanW family HBA75_17395 ENOG4108R1P HBA75_17410 ENOG4105VEQ Cold shock protein HBA75_17430 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HBA75_17480 ENOG410904N short-chain dehydrogenase reductase HBA75_17490 ENOG4106IQC argininosuccinate lyase HBA75_17505 ENOG4108IA2 Sodium pantothenate symporter HBA75_17515 ENOG4105C26 Dehydrogenase HBA75_17520 ENOG4105CHR reductase HBA75_17530 ENOG4105EWU Squalene--hopene cyclase HBA75_17540 ENOG4105FR1 rard protein HBA75_17550 ENOG410696E Membrane HBA75_17565 ENOG4105D1F ATP-binding protein HBA75_17575 ENOG4108ZAF Molybdopterin HBA75_17580 ENOG4105CVM Molybdenum cofactor synthesis domain protein HBA75_17585 ENOG4105D06 uba thif-type nad fad binding protein HBA75_17590 ENOG4105TMB Formate nitrite transporter HBA75_17600 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HBA75_17605 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HBA75_17615 ENOG4108JB9 formate dehydrogenase HBA75_17620 ENOG4105E1K spore germination protein HBA75_17635 ENOG4105CUB amino acid HBA75_17690 ENOG4107QJT sodium dicarboxylate symporter HBA75_17695 ENOG4108KGH TRANSCRIPTIONal HBA75_17705 ENOG4105EMN RNA polymerase sigma factor HBA75_17720 ENOG4105CIG ABC transporter HBA75_17730 ENOG4105D9R oxidoreductase HBA75_17740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HBA75_17745 ENOG4105K4P CoA-binding domain protein HBA75_17750 ENOG4105C0H protease HBA75_17755 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_17765 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HBA75_17775 ENOG4105W8X HesB YadR YfhF-family protein HBA75_17810 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HBA75_17815 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HBA75_17825 ENOG4105BZ1 (ABC) transporter HBA75_17830 ENOG4108I0Z Aconitate hydratase HBA75_17860 ENOG4105E5W Transporter HBA75_17870 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HBA75_17890 ENOG4107F3J Amp-dependent synthetase and ligase HBA75_17895 ENOG4107ZYJ bioY protein HBA75_17900 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_17945 ENOG4107AYK membrAne HBA75_17955 ENOG4105BZU Histidine kinase HBA75_17960 ENOG4105FBA Phospholipase Carboxylesterase HBA75_17965 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HBA75_17970 ENOG4105CK7 Sodium proline symporter HBA75_17980 ENOG4105CBC glutamate synthase HBA75_17990 ENOG4105EKQ RNA-directed DNA polymerase HBA75_18000 ENOG4108VJ1 Transcriptional regulator (CarD family HBA75_18005 ENOG4108903 Formimidoylglutamase HBA75_18060 ENOG4107QIV Cytochrome c biogenesis protein HBA75_18095 ENOG4107RSM transcriptional regulator HBA75_18105 ENOG41067MG lrgb family HBA75_18145 ENOG4105BZ1 (ABC) transporter HBA75_18150 ENOG4105BZ1 (ABC) transporter HBA75_18200 ENOG4105CGH 5'-nucleotidase HBA75_18210 ENOG4108SVB resolvase HBA75_18230 ENOG4105K7K Transcriptional regulator HBA75_18240 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_18245 ENOG4105DR5 peptidase HBA75_18250 ENOG41065S2 pneumococcal vaccine antigen HBA75_18280 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HBA75_18285 ENOG4105C5F glutamine synthetase HBA75_18290 ENOG4105KV4 Transcriptional regulator HBA75_18295 ENOG4105CXI aluminum resistance protein HBA75_18300 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HBA75_18305 ENOG4105EN6 Membrane HBA75_18315 ENOG4106F1P AAA ATPase, central domain protein HBA75_18350 ENOG41069ER domain protein HBA75_18355 ENOG4105DM4 PTS System HBA75_18360 ENOG4105DE4 1-phosphofructokinase HBA75_18365 ENOG4105E98 transcriptional regulator DeoR family HBA75_18370 ENOG4107QW4 alcohol dehydrogenase HBA75_18375 ENOG4108SJC Membrane HBA75_18385 ENOG4105C85 amino acid HBA75_18400 ENOG4105TMB Formate nitrite transporter HBA75_18405 ENOG4105K70 DNA-binding protein HBA75_18415 ENOG4105C59 p-type ATPase HBA75_18420 ENOG410681U heavy metal transport detoxification protein HBA75_18425 ENOG4105VPX protein, conserved in bacteria HBA75_18435 ENOG4105NIV Esterase HBA75_18440 ENOG4105E0A ABC, transporter HBA75_18470 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HBA75_18475 ENOG4105D03 DNA-3-methyladenine glycosylase II HBA75_18500 ENOG4105BZU Histidine kinase HBA75_18540 ENOG41067MG lrgb family HBA75_18555 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HBA75_18560 ENOG4107YEI lmbE family HBA75_18580 ENOG4105F0V Cell wall hydrolase HBA75_18590 ENOG4105E0M Sulfatase HBA75_18595 ENOG410890F Dynamin family HBA75_18630 ENOG4105DQU oxidoreductase, subunit beta HBA75_18635 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HBA75_18640 ENOG4108IGT Dipeptidase HBA75_18645 ENOG4105MCT stage V sporulation protein S HBA75_18650 ENOG4105D48 metallophosphoesterase HBA75_18670 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HBA75_18685 ENOG4105XZV Protein of unknown function (DUF3243) HBA75_18690 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HBA75_18710 ENOG4105UIB (ABC) transporter HBA75_18715 ENOG4108JQ9 ABC transporter HBA75_18720 ENOG4105DIH basic membrane HBA75_18725 ENOG4105FDP GntR family transcriptional regulator HBA75_18735 ENOG4105CNU cell division protein FtsK HBA75_18745 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HBA75_18755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HBA75_18765 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HBA75_18770 ENOG4108S0H Dipicolinic acid synthetase, b subunit HBA75_18775 ENOG4105E35 Dipicolinate synthase subunit A HBA75_18785 ENOG4105C1V Peptidase, M16 HBA75_18805 ENOG4105DTN riboflavin biosynthesis protein ribF HBA75_18820 ENOG4105W7A Protein of unknown function (DUF503) HBA75_18830 ENOG4105VHM ribosomal protein HBA75_18835 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HBA75_18840 ENOG4105CHV Transcription elongation factor NusA HBA75_18850 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HBA75_18860 ENOG4105DZP Membrane-associated zinc metalloprotease HBA75_18865 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HBA75_18870 ENOG4105KNE Phosphatidate cytidylyltransferase HBA75_18875 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HBA75_18885 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HBA75_18915 ENOG4108HE4 integrase family HBA75_18925 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HBA75_18930 ENOG4105C79 DNA protecting protein DprA HBA75_18935 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HBA75_18950 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HBA75_18975 ENOG4105VB6 UPF0109 protein HBA75_18995 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HBA75_19000 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HBA75_19015 ENOG4105CHR reductase HBA75_19020 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HBA75_19035 ENOG4105CB5 ATP-dependent DNA helicase recG HBA75_19040 ENOG4105DP4 dak2 domain fusion protein ylov HBA75_19045 ENOG4108ZAA Alkaline-shock protein HBA75_19060 ENOG4105FJ0 thiamine HBA75_19065 ENOG4105DJV ribulose-phosphate 3-epimerase HBA75_19070 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HBA75_19075 ENOG4105D9P serine threonine protein kinase HBA75_19080 ENOG4108ZF3 Phosphatase HBA75_19090 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HBA75_19105 ENOG4105C25 Primosomal protein n' HBA75_19110 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HBA75_19130 ENOG4105DSJ YicC domain protein HBA75_19145 ENOG4105DC7 peptidase M24 HBA75_19170 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HBA75_19185 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HBA75_19190 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HBA75_19200 ENOG4105CD3 dihydroorotase HBA75_19220 ENOG4105C34 Pseudouridine synthase HBA75_19245 ENOG4105DBK s4 domain protein HBA75_19250 ENOG41067XK integral membrane protein HBA75_19260 ENOG4105DFA alanine racemase domain protein HBA75_19265 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HBA75_19270 ENOG4105WR5 sporulation protein, YlmC YmxH family HBA75_19280 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_19290 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HBA75_19295 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HBA75_19305 ENOG4105D4A Cell wall formation (By similarity) HBA75_19310 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HBA75_19315 ENOG4105CNI cell division protein FtsW HBA75_19330 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HBA75_19335 ENOG4105CJN penicillin-binding protein HBA75_19340 ENOG4105CJN penicillin-binding protein HBA75_19355 ENOG41074B2 UPF0747 protein HBA75_19380 ENOG4105KNH Nucleic acid-binding protein HBA75_19390 ENOG41063PX domain protein HBA75_19395 ENOG4105D78 K07001 NTE family protein HBA75_19400 ENOG4105H20 Sporulation integral membrane protein YlbJ HBA75_19410 ENOG4106H78 methyltransferase HBA75_19430 ENOG4107TB6 phosphoglycerate mutase HBA75_19445 ENOG4106UY4 Inherit from COG: Scp-like extracellular HBA75_19495 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HBA75_19500 ENOG4105CNI cell division protein FtsW HBA75_19515 ENOG4108IAB Phoh family HBA75_19535 ENOG4105QA2 HBA75_19540 ENOG4105CI3 gtp-binding protein typa HBA75_19550 ENOG4105ECY inositol monophosphatase HBA75_19570 ENOG4105CXN decarboxylase HBA75_19620 ENOG4105CPP Dehydrogenase, E1 component HBA75_19635 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HBA75_19640 ENOG4108X4Q Hydrolase HBA75_19650 ENOG4105CN5 Metallo-Beta-Lactamase HBA75_19655 ENOG4107ZYR domain protein HBA75_19690 ENOG4108XRC Protein of unknown function (DUF458) HBA75_19700 ENOG4107IN1 Protein of unknown function (DUF1797) HBA75_19715 ENOG4105EPM Diguanylate phosphodiesterase HBA75_19720 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HBA75_19735 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HBA75_19745 ENOG4105UIN HBA75_19780 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HBA75_19800 ENOG4108HGU Histidine kinase HBA75_19810 ENOG4105CHM Aminotransferase HBA75_19815 ENOG4105FKQ transcriptional regulator HBA75_19820 ENOG4105EG2 ABC transporter, permease HBA75_19830 ENOG4107FKK extracellular solute-binding protein family 1 HBA75_19840 ENOG4105CG3 alpha amylase, catalytic region HBA75_19890 ENOG4105CHU acetyl-coa acetyltransferase HBA75_19925 ENOG4105K7K Transcriptional regulator HBA75_19930 ENOG4105DTD Dehydrogenase HBA75_19960 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HBA75_19985 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HBA75_20000 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HBA75_20010 ENOG4105BZU Histidine kinase HBA75_20030 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HBA75_20045 ENOG4105CID antiterminator HBA75_20065 ENOG4105CE4 GlcNAc 6-P deacetylase HBA75_20100 ENOG4107ZE5 PPIases accelerate the folding of proteins HBA75_20105 ENOG4105PTM secreted protein HBA75_20110 ENOG4105DQ6 Transposase HBA75_20120 ENOG4105J7I hydrolase HBA75_20130 ENOG4105G6R Stage v sporulation protein ae HBA75_20155 ENOG41090VF Stage v sporulation protein ac HBA75_20175 ENOG4105C8J )-transporter HBA75_20180 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_20190 ENOG41082AN stage II sporulation protein HBA75_20195 ENOG4105DZ1 carboxypeptidase HBA75_20200 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HBA75_20205 ENOG4105DVE abc transporter atp-binding protein HBA75_20240 ENOG4105D7N magnesium and cobalt transport protein CorA HBA75_20265 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBA75_20275 ENOG4105I3K Ferric uptake regulator, Fur family HBA75_20280 ENOG4105MZ9 stage II sporulation protein m HBA75_20300 ENOG4105CPC Aldo Keto reductase HBA75_20310 ENOG4105RHY Pfam:UPF0157 HBA75_20330 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HBA75_20340 ENOG4105ETE Transcriptional regulator (LacI family HBA75_20345 ENOG4108YM7 Gcn5-related n-acetyltransferase HBA75_20365 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HBA75_20370 ENOG4108R6K riboflavin synthase, subunit alpha HBA75_20395 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_20400 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HBA75_20410 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HBA75_20415 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HBA75_20425 ENOG4105DFD Na H antiporter HBA75_20430 ENOG4105CGH 5'-nucleotidase HBA75_20455 ENOG4105DBV ornithine carbamoyltransferase HBA75_20470 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HBA75_20485 ENOG4108IXY short-chain dehydrogenase reductase HBA75_20490 ENOG41069FQ Metallo-beta-lactamase superfamily HBA75_20495 ENOG4105II7 pyrroline-5-carboxylate reductase HBA75_20500 ENOG4105EJQ L-serine dehydratase HBA75_20515 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HBA75_20535 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HBA75_20550 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HBA75_20555 ENOG4105D9U N-acetyltransferase HBA75_20570 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HBA75_20575 ENOG4108QEG Membrane HBA75_20580 ENOG4105CDA abc transporter atp-binding protein HBA75_20585 ENOG4105E5Q amino acid AbC transporter HBA75_20590 ENOG4108HW3 (ABC) transporter HBA75_20600 ENOG4105G7B Protein of unknown function (DUF2992) HBA75_20605 ENOG4105E09 nadh pyrophosphatase HBA75_20610 ENOG4108QY0 Membrane HBA75_20620 ENOG4105C7S Dehydrogenase HBA75_20625 ENOG4105CPP Dehydrogenase, E1 component HBA75_20640 ENOG4105CKM Branched-chain carboxylic acid kinase HBA75_20645 ENOG4107RDP Dehydrogenase HBA75_20655 ENOG4108JUB Transcriptional regulator HBA75_20665 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HBA75_20685 ENOG4107QQR Sporulation HBA75_20690 ENOG4105S1Z Stage IV sporulation protein B HBA75_20695 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HBA75_20710 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HBA75_20720 ENOG4105DX0 Hemolysin A HBA75_20730 ENOG4105CTB Polyprenyl synthetase HBA75_20745 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HBA75_20755 ENOG4108ZSR alkaline shock protein HBA75_20760 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HBA75_20785 ENOG410644B Stage III sporulation protein af HBA75_20795 ENOG4105KQ4 Stage iii sporulation protein ad HBA75_20800 ENOG4108CQH stage III sporulation protein AC HBA75_20805 ENOG4105KR5 Stage iii sporulation protein HBA75_20810 ENOG4105CD2 stage iii sporulation protein aa HBA75_20835 ENOG4105DC7 peptidase M24 HBA75_20840 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HBA75_20855 ENOG4105CBJ Metal-dependent enzyme HBA75_20865 ENOG4107YBY Hydrolase HBA75_20880 ENOG4105K7K Transcriptional regulator HBA75_20895 ENOG41082GG biotin lipoate A B protein ligase HBA75_20900 ENOG4105WZW rhodanese family HBA75_20925 ENOG41080TC multidrug resistance protein HBA75_20960 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HBA75_20990 ENOG4105C0D helicase HBA75_21110 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HBA75_21115 ENOG4105C3R Methionine synthase HBA75_21125 ENOG4105C28 cystathionine HBA75_21130 ENOG4105C28 cystathionine HBA75_21155 ENOG4105C5X domain protein HBA75_21165 ENOG4105DKQ ROK family HBA75_21175 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HBA75_21190 ENOG4108UTW Plays a role in the regulation of phosphate uptake HBA75_21195 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HBA75_21200 ENOG4105C8U phosphate abc transporter HBA75_21205 ENOG4105C8U phosphate abc transporter HBA75_21210 ENOG4105EXS phosphate abc transporter HBA75_21215 ENOG4107RF6 penicillin-binding protein HBA75_21225 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBA75_21250 ENOG4105N80 Ferric uptake regulator, Fur family HBA75_21260 ENOG4105FDK ABC transporter HBA75_21265 ENOG4108JYZ YitT family HBA75_21270 ENOG41069ZM Protein of unknown function (DUF2624) HBA75_21295 ENOG4105EGD dinuclear metal center protein, YbgI family HBA75_21310 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_21315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HBA75_21345 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HBA75_21350 ENOG4105KG3 cytidine deaminase HBA75_21355 ENOG4107YR5 Diacylglycerol kinase HBA75_21360 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HBA75_21365 ENOG4105CTJ Metal Dependent Phosphohydrolase HBA75_21370 ENOG4105C9A Phoh family HBA75_21380 ENOG41068P3 sporulation protein YqfC HBA75_21390 ENOG4105KTH gatB Yqey HBA75_21400 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HBA75_21405 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HBA75_21435 ENOG4105CSA Coproporphyrinogen iii oxidase HBA75_21440 ENOG4105KVH Transcriptional regulator HBA75_21450 ENOG4105DQ6 Transposase HBA75_21475 ENOG4105TQK DNA polymerase iii, delta' subunit HBA75_21490 ENOG4108UK2 deaminase HBA75_21495 ENOG4105KQC Competence protein HBA75_21505 ENOG4105DXX methyltransferase HBA75_21515 ENOG4108WF2 Metal Dependent Phosphohydrolase HBA75_21525 ENOG410812S Rna-binding protein HBA75_21535 ENOG4105CQW ribosome biogenesis GTPase YqeH HBA75_21540 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HBA75_21555 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_21575 ENOG4108TVJ Nitroreductase HBA75_21590 ENOG4105G6Z alkaline phosphatase HBA75_21595 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HBA75_21600 ENOG4108MUZ hydrolase HBA75_21635 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HBA75_21650 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HBA75_21690 ENOG4105S6R Iron-hydroxamate transporter permease subunit HBA75_21695 ENOG4108V5C ABC transporter HBA75_21705 ENOG4105C0A alcohol dehydrogenase HBA75_21710 ENOG4105C28 cystathionine HBA75_21750 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HBA75_21760 ENOG4105CFP Peptidase U32 HBA75_21765 ENOG4105XYU peptidase (U32 family) HBA75_21775 ENOG4105HHA aminodeoxychorismate lyase HBA75_21795 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HBA75_21805 ENOG4105C02 permease HBA75_21820 ENOG41060CR HBA75_21825 ENOG4105C7H Helicase, RecD TraA family HBA75_21835 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HBA75_21840 ENOG4105C3J Cysteine desulfurase HBA75_21850 ENOG4105D1H recombination factor protein RarA HBA75_21855 ENOG4108VCI transcription factor, rsfa family HBA75_21860 ENOG4105CUZ uba thif-type nad fad binding protein HBA75_21870 ENOG4105CUT histidyl-tRNA synthetase HBA75_21880 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HBA75_21885 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HBA75_21895 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HBA75_21900 ENOG41076HS cation diffusion facilitator family transporter HBA75_21905 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HBA75_21915 ENOG4105CKP Polysaccharide Biosynthesis Protein HBA75_21920 ENOG4108QG2 Membrane HBA75_21935 ENOG4105VIE preprotein translocase, subunit YajC HBA75_21950 ENOG41061AI Protein of unknown function (DUF2905) HBA75_21965 ENOG4108HUF Transporter HBA75_22000 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HBA75_22005 ENOG4108IYU L-aspartate oxidase HBA75_22020 ENOG4108RPX mosc domain containing protein HBA75_22025 ENOG4105CQC Prephenate dehydratase HBA75_22040 ENOG4105C19 ABC transporter HBA75_22045 ENOG4105EWM Histidine kinase HBA75_22055 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HBA75_22070 ENOG4105X36 (ribosomal) protein HBA75_22080 ENOG4105C03 ribonuclease HBA75_22095 ENOG4107QMS site-determining protein HBA75_22115 ENOG4105DFF Rod shape-determining protein mreb HBA75_22145 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_22150 ENOG4105XSJ toxin secretion phage lysis holin HBA75_22270 ENOG41085W3 Transposase HBA75_22295 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HBA75_22320 ENOG4105EKQ RNA-directed DNA polymerase HBA75_22390 ENOG4106050 phage regulatory protein, rha family HBA75_22410 ENOG4107Y5K Resolvase HBA75_22430 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HBA75_22435 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HBA75_22445 ENOG41068KH stage VI sporulation protein D HBA75_22455 ENOG4105D52 delta-aminolevulinic acid dehydratase HBA75_22480 ENOG4105K56 Transcriptional regulator HBA75_22505 ENOG4108IUQ atp-dependent protease HBA75_22530 ENOG4108QCI YvbH-like oligomerisation region HBA75_22550 ENOG4105M59 Phosphodiesterase, mj0936 family HBA75_22555 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HBA75_22565 ENOG4108XJQ germination protein HBA75_22575 ENOG4108PCX Major Facilitator HBA75_22585 ENOG4105KBX Transcriptional regulator, TetR family HBA75_22595 ENOG4105PFC Transcriptional regulator HBA75_22605 ENOG4105DZC cytosine deaminase HBA75_22610 ENOG41067S9 phage shock protein C, PspC HBA75_22615 ENOG4108JCI Transcriptional regulator HBA75_22625 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HBA75_22630 ENOG4108Z40 Transcriptional regulator HBA75_22635 ENOG4105RHA ABC transporter, permease HBA75_22640 ENOG4108IUX (ABC) transporter HBA75_22645 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HBA75_22650 ENOG4105ER2 Ompa motb domain protein HBA75_22655 ENOG4105E14 MotA TolQ exbB proton channel HBA75_22660 ENOG4108VXD carboxy-peptidase HBA75_22670 ENOG4105E33 succinate dehydrogenase HBA75_22680 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HBA75_22690 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HBA75_22695 ENOG4105K63 Thioredoxin HBA75_22700 ENOG4105C10 Electron transfer flavoprotein HBA75_22705 ENOG4105BZJ Electron transfer flavoprotein HBA75_22710 ENOG41060WC Enoyl-CoA hydratase HBA75_22715 ENOG4107Z3H Transcriptional regulator, TetR family HBA75_22720 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_22730 ENOG4105J76 Periplasmic binding protein HBA75_22735 ENOG4105S6R Iron-hydroxamate transporter permease subunit HBA75_22785 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_22800 ENOG4105DR4 Methyltransferase HBA75_22810 ENOG4105KFN sortase, SrtB family HBA75_22815 ENOG4105E0A ABC, transporter HBA75_22830 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) HBA75_22840 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) HBA75_22850 ENOG4105FE9 pseudouridine synthase HBA75_22860 ENOG4105DCG PHP domain protein HBA75_22875 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HBA75_22890 ENOG4105C5S asparaginyl-tRNA synthetase HBA75_22895 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HBA75_22905 ENOG4108RWN rrna methyltransferase HBA75_22930 ENOG4105C0R drug resistance transporter emrb qaca subfamily HBA75_22935 ENOG4105CW7 secretion protein, HlyD family HBA75_22940 ENOG4108JGH Tetr family transcriptional regulator HBA75_22945 ENOG4105CN9 Peptidase m42 family protein HBA75_22965 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HBA75_22970 ENOG4105DQ6 Transposase HBA75_22980 ENOG4105C22 threonyL-tRNA synthetase HBA75_22985 ENOG4108TDW sporulation protein YtxC HBA75_23015 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HBA75_23020 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HBA75_23030 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HBA75_23035 ENOG4105C2M dna polymerase I HBA75_23040 ENOG4105BZU Histidine kinase HBA75_23045 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_23055 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HBA75_23060 ENOG4108HMX isocitrate dehydrogenase (NADP) HBA75_23065 ENOG4105BZN citrate synthase HBA75_23075 ENOG4108REF Sporulation integral membrane protein ytvi HBA75_23080 ENOG4105FS0 cytoplasmic membrane protein HBA75_23105 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HBA75_23110 ENOG4105C6K Malic enzyme HBA75_23115 ENOG4105C0B DNA polymerase III (alpha subunit) HBA75_23120 ENOG4105VV2 HBA75_23130 ENOG4105SFS phosphoesterase RecJ domain protein HBA75_23160 ENOG4105DC7 peptidase M24 HBA75_23185 ENOG410836F Transposase HBA75_23195 ENOG4105Z7P Acetyltransferase (GNAT) family HBA75_23200 ENOG41082W1 Cupin 2, conserved barrel domain protein HBA75_23220 ENOG4107YZX Universal stress protein HBA75_23260 ENOG4108JYZ YitT family HBA75_23280 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HBA75_23290 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HBA75_23295 ENOG4105KBJ sporulation protein ytfj HBA75_23310 ENOG4105EFZ amidohydrolase HBA75_23320 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HBA75_23365 ENOG4105U5Y Transcriptional regulator HBA75_23375 ENOG4105C28 cystathionine HBA75_23405 ENOG4108UW5 maltose o-acetyltransferase HBA75_23415 ENOG4105F1V Acetoin utilization protein HBA75_23420 ENOG4105W87 Cbs domain HBA75_23425 ENOG4105DGU Histone deacetylase HBA75_23440 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HBA75_23450 ENOG4107SNB ankyrin repeat protein YahD HBA75_23455 ENOG4105EP9 oxidoreductase HBA75_23485 ENOG4105ETE Transcriptional regulator (LacI family HBA75_23490 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HBA75_23510 ENOG4105C88 aminopeptidase HBA75_23545 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HBA75_23555 ENOG4108VDD TRNA binding domain protein HBA75_23585 ENOG4105C8F Beta-lactamase domain protein HBA75_23605 ENOG4108V15 phosphotransferase enzyme family HBA75_23615 ENOG4108IUM Glycogen debranching enzyme HBA75_23625 ENOG4107QSE Dipeptidase HBA75_23630 ENOG4105YW5 deoR family transcriptional regulator HBA75_23645 ENOG4105CBX hi0933 family HBA75_23690 ENOG4108VJ1 Transcriptional regulator (CarD family HBA75_23695 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HBA75_23700 ENOG4105CSC Glucose uptake protein HBA75_23715 ENOG4108ZAF Molybdopterin HBA75_23720 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HBA75_23725 ENOG4105CVM Molybdenum cofactor synthesis domain protein HBA75_23735 ENOG4105D06 uba thif-type nad fad binding protein HBA75_23740 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBA75_23765 ENOG41085GJ domain protein HBA75_23775 ENOG4105DWV Homoserine O-trans-acetylase HBA75_23785 ENOG4108B31 Spore germination protein HBA75_23815 ENOG4105C8T Leucyl-tRNA synthetase HBA75_23825 ENOG4107S91 Sodium hydrogen exchanger HBA75_23830 ENOG4105NCW Trka-c domain protein HBA75_23845 ENOG4105C19 ABC transporter HBA75_23865 ENOG4105N5T Radical SAM Protein HBA75_23890 ENOG4105E8V Alpha Beta Hydrolase Fold protein HBA75_23895 ENOG4108Z0R Transferase HBA75_23900 ENOG4105YVM Phosphoesterase, PA-phosphatase related HBA75_23905 ENOG4105BZF Glycosyl transferase (Group 1 HBA75_23915 ENOG4105EPU Molybdenum cofactor synthesis domain protein HBA75_23925 ENOG4108MK9 spermidine N(1)-acetyltransferase HBA75_23970 ENOG4105BZU Histidine kinase HBA75_23975 ENOG4105BZU Histidine kinase HBA75_23980 ENOG4105CH6 catalase HBA75_23990 ENOG4107S9D Alpha beta hydrolase HBA75_23995 ENOG4107T7U Sulfatase HBA75_24020 ENOG4105D2X ABC transporter substrate-binding protein HBA75_24030 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HBA75_24055 ENOG4105DQ6 Transposase HBA75_24110 ENOG4108V2W Carbonate dehydratase HBA75_24115 ENOG4105C4M (Ubiquinol oxidase) subunit I HBA75_24120 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HBA75_24160 ENOG41087YS Phage shock protein A HBA75_24190 ENOG4105BZU Histidine kinase HBA75_24195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_24220 ENOG4108UGV hypoxanthine phosphoribosyltransferase HBA75_24225 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HBA75_24245 ENOG4105EKQ RNA-directed DNA polymerase HBA75_24290 ENOG4107ZTW SNARE associated Golgi HBA75_24305 ENOG4105C19 ABC transporter HBA75_24310 ENOG41086D8 Transcriptional regulator HBA75_24335 ENOG41082BM Transcriptional regulator, arsr family HBA75_24385 ENOG4105C6Z Gluconate HBA75_24410 ENOG41069H0 dihydroorotase EC 3.5.2.3 HBA75_24430 ENOG4105DTQ mandelate racemase muconate lactonizing HBA75_24435 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_24440 ENOG4108IPT Naphthoate synthase HBA75_24445 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HBA75_24450 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HBA75_24455 ENOG4105E4F Isochorismate synthase HBA75_24460 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HBA75_24470 ENOG4105VEQ Cold shock protein HBA75_24505 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HBA75_24520 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HBA75_24620 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HBA75_24655 ENOG4105KT7 mgtC SapB transporter HBA75_24660 ENOG4107PBV potassium channel HBA75_24675 ENOG4105WG9 Conserved Protein HBA75_24685 ENOG4105CHM Aminotransferase HBA75_24690 ENOG4108ZB6 transcriptional regulator AsnC family HBA75_24695 ENOG4105C5I Dehydrogenase HBA75_24700 ENOG4108MUZ hydrolase HBA75_24710 ENOG4105C87 Aminotransferase class I and II HBA75_24725 ENOG4105Y38 Kinase-associated protein B HBA75_24735 ENOG4107R3E Citrate transporter HBA75_24755 ENOG4105KA0 thioesterase Superfamily protein HBA75_24770 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HBA75_24795 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HBA75_24800 ENOG4106YN8 Prenyltransferase HBA75_24810 ENOG41069ER domain protein HBA75_24825 ENOG4105CEP NADH dehydrogenase HBA75_24855 ENOG4105EWC Purine nucleoside phosphorylase HBA75_24910 ENOG4105XSJ toxin secretion phage lysis holin HBA75_25050 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_25075 ENOG4108ZUE Phage regulatory protein rha HBA75_25095 ENOG4108IMY Transcriptional regulator HBA75_25135 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HBA75_25160 ENOG4108JJA ABC, transporter HBA75_25165 ENOG4105C4B ABC transporter, permease HBA75_25170 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HBA75_25215 ENOG4105EKQ RNA-directed DNA polymerase HBA75_25250 ENOG41083MR nifu domain-containing protein HBA75_25265 ENOG4108W5N phosphatidylglycerophosphatase a HBA75_25285 ENOG4105DAX Pfam:DUF2983 HBA75_25295 ENOG4105DYS nad(p)h dehydrogenase (quinone) HBA75_25305 ENOG4105D4U had-superfamily hydrolase, subfamily iia HBA75_25320 ENOG4105CBT Fructose-1,6-bisphosphatase HBA75_25340 ENOG4105MMD transcriptional regulator HBA75_25345 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HBA75_25350 ENOG4107TXC Transcriptional regulator HBA75_25355 ENOG41090T1 Membrane HBA75_25380 ENOG4105FAA peptidase M23 HBA75_25385 ENOG4108YTE sporulation protein YunB HBA75_25390 ENOG4105KZD Domain of unknown function (DUF1805) HBA75_25395 ENOG4107R8B 5'-nucleotidase HBA75_25400 ENOG4105DIW FeS assembly protein SUFB HBA75_25405 ENOG4108UNV SUF system FeS assembly protein, NifU family HBA75_25410 ENOG4105C9B Cysteine desulfurase HBA75_25415 ENOG4105JRK feS assembly protein SufD HBA75_25420 ENOG4105C3K feS assembly ATPase SufC HBA75_25425 ENOG4105D01 (LipO)protein HBA75_25430 ENOG4105D01 (LipO)protein HBA75_25435 ENOG4108UMI ABC transporter, permease HBA75_25440 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HBA75_25465 ENOG41080E8 Transcriptional regulator, Spx MgsR family HBA75_25485 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HBA75_25510 ENOG4108W8B Beta-lactamase domain protein HBA75_25515 ENOG4105C1G acyl-Coa dehydrogenase HBA75_25520 ENOG4105CHU acetyl-coa acetyltransferase HBA75_25535 ENOG4105DZ1 carboxypeptidase HBA75_25555 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HBA75_25570 ENOG4108SUT Major Facilitator Superfamily HBA75_25575 ENOG4107R7I amino acid HBA75_25590 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HBA75_25600 ENOG4107AYK membrAne HBA75_25635 ENOG4107ZTW SNARE associated Golgi HBA75_25645 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HBA75_25650 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_25655 ENOG4105BZU Histidine kinase HBA75_25670 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HBA75_25700 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_25705 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_25710 ENOG4105VG1 fes assembly suf system protein HBA75_25715 ENOG4105D4Y metalloprotease HBA75_25720 ENOG4105C2I pirin domain protein HBA75_25735 ENOG4107T5V SNARE associated Golgi HBA75_25740 ENOG4107S91 Sodium hydrogen exchanger HBA75_25745 ENOG4105NCW Trka-c domain protein HBA75_25760 ENOG4108RMU ferritin dps family protein HBA75_25775 ENOG4108URH decarboxylase HBA75_25785 ENOG41090A1 ferritin HBA75_25795 ENOG4105D9N nucleoside HBA75_25800 ENOG4105D9N nucleoside HBA75_25815 ENOG4108RYK Nad-dependent epimerase dehydratase HBA75_25830 ENOG4105CV8 reductase HBA75_25835 ENOG4105F27 Major Facilitator HBA75_25840 ENOG4105KVH Transcriptional regulator HBA75_25855 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HBA75_25860 ENOG4105D4A Cell wall formation (By similarity) HBA75_25880 ENOG4105WMR Protein CrcB homolog HBA75_25885 ENOG4105WMR Protein CrcB homolog HBA75_25900 ENOG4108MK9 spermidine N(1)-acetyltransferase HBA75_25915 ENOG4108W2Y isochorismatase HBA75_25945 ENOG4108IPW abc transporter atp-binding protein HBA75_25950 ENOG4105CM4 permease protein HBA75_25965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_25985 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HBA75_25990 ENOG410836F Transposase HBA75_26015 ENOG4105CNU cell division protein FtsK HBA75_26040 ENOG4105XSJ toxin secretion phage lysis holin HBA75_26050 ENOG410836F Transposase HBA75_26250 ENOG4106050 phage regulatory protein, rha family HBA75_26270 ENOG4108IMY Transcriptional regulator HBA75_26290 ENOG4105XZU Preprotein translocase, subunit SecG HBA75_26295 ENOG41067MG lrgb family HBA75_26345 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_26370 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_26375 ENOG4105XSJ toxin secretion phage lysis holin HBA75_26450 ENOG41085W3 Transposase HBA75_26520 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HBA75_26625 ENOG4106050 phage regulatory protein, rha family HBA75_26655 ENOG4105VTR Integrase HBA75_26710 ENOG4105KQC Competence protein HBA75_26720 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HBA75_26735 ENOG41090VF Stage v sporulation protein ac HBA75_26740 ENOG4105CZ3 stage V sporulation protein ad HBA75_26755 ENOG4108QY0 Membrane HBA75_26765 ENOG4105KRI phosphocarrier protein (HPr HBA75_26775 ENOG4105CHW UPF0052 protein HBA75_26785 ENOG4108Z4K mutator MutT protein HBA75_26795 ENOG4105C3M thioredoxin reductase HBA75_26805 ENOG4108S4C acetyltransferase HBA75_26825 ENOG41086DT Membrane protein of unknown function HBA75_26835 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HBA75_26840 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HBA75_26855 ENOG4107TXC Transcriptional regulator HBA75_26875 ENOG4105DUM transcriptional regulator, lysR family HBA75_26885 ENOG4108WS4 fmn reductase HBA75_26890 ENOG4105C5H ABC transporter HBA75_26900 ENOG4105BZ1 (ABC) transporter HBA75_26910 ENOG4105CN1 protease HBA75_26915 ENOG4105CRP Part of the ABC transporter FtsEX involved in HBA75_26920 ENOG4105CAK Cell division ATP-binding protein ftsE HBA75_26940 ENOG4105MS2 ribosomal subunit Interface protein HBA75_26945 ENOG4105VEQ Cold shock protein HBA75_26950 ENOG41081UC Inherit from COG: Competence protein HBA75_26960 ENOG4105K4H Nlp p60 protein HBA75_26965 ENOG4105KVH Transcriptional regulator HBA75_26975 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HBA75_26980 ENOG4108KGH TRANSCRIPTIONal HBA75_26985 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HBA75_26990 ENOG4105C6Y Udp-glucose 6-dehydrogenase HBA75_26995 ENOG4105ESV Glycosyl transferase, family 4 HBA75_27005 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HBA75_27025 ENOG4105F8D glycoside hydrolase family 4 HBA75_27030 ENOG4105VCP PTS System HBA75_27035 ENOG4105CK1 PTS System HBA75_27045 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HBA75_27050 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HBA75_27055 ENOG4105VCP PTS System HBA75_27065 ENOG4105VZJ PTS System HBA75_27085 ENOG4105ECB domain protein HBA75_27090 ENOG4107RSM transcriptional regulator HBA75_27125 ENOG4105DAA L-lactate HBA75_27135 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) HBA75_27145 ENOG4105E0M Sulfatase HBA75_27185 ENOG4105C94 Transporter HBA75_27190 ENOG41069ER domain protein HBA75_27225 ENOG4105KBK Zinc finger, swim domain protein HBA75_27230 ENOG4105C0D helicase HBA75_27240 ENOG41085W3 Transposase HBA75_27265 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HBA75_27275 ENOG4107RBB ABC transporter, permease HBA75_27280 ENOG4105C19 ABC transporter HBA75_27300 ENOG4105CXY transporter HBA75_27315 ENOG4105BZU Histidine kinase HBA75_27320 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_27325 ENOG4105DG6 mannose-6-phosphate isomerase HBA75_27330 ENOG4105DM4 PTS System HBA75_27350 ENOG4108KGH TRANSCRIPTIONal HBA75_27355 ENOG4105DG6 mannose-6-phosphate isomerase HBA75_27380 ENOG4108TJN glycosyl transferase group 1 HBA75_27385 ENOG4105C6Y Udp-glucose 6-dehydrogenase HBA75_27390 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HBA75_27400 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HBA75_27405 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HBA75_27430 ENOG4105D3Q Sugar transferase HBA75_27435 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HBA75_27440 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HBA75_27445 ENOG4107YJ4 chain length determinant protein HBA75_27450 ENOG4105HTX biosynthesis protein HBA75_27455 ENOG4107YJ4 chain length determinant protein HBA75_27470 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HBA75_27480 ENOG4105FRN stage II sporulation protein HBA75_27495 ENOG4105DY9 regulatoR HBA75_27515 ENOG4106778 Protein of unknown function (DUF1146) HBA75_27520 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HBA75_27525 ENOG4105C8S subunit m HBA75_27530 ENOG4105D65 subunit l HBA75_27555 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HBA75_27560 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HBA75_27570 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HBA75_27575 ENOG4105BZU Histidine kinase HBA75_27625 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) HBA75_27630 ENOG41062M3 atp synthase HBA75_27650 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HBA75_27655 ENOG4108UIC UPF0340 protein HBA75_27660 ENOG4108YZG isomerase HBA75_27675 ENOG4108VGI doxx family HBA75_27680 ENOG4107XC4 flavin reductase domain protein, FMN-binding HBA75_27695 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HBA75_27705 ENOG4108ZXQ stage ii sporulation protein r HBA75_27710 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HBA75_27715 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HBA75_27720 ENOG4107104 thymidine kinase HBA75_27730 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HBA75_27735 ENOG4105CBT Fructose-1,6-bisphosphatase HBA75_27740 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HBA75_27760 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HBA75_27775 ENOG4105C1G acyl-Coa dehydrogenase HBA75_27780 ENOG4105C1G acyl-Coa dehydrogenase HBA75_27785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HBA75_27795 ENOG4105DF6 Fe-S oxidoreductase HBA75_27815 ENOG4105BZU Histidine kinase HBA75_27830 ENOG4105D4Y metalloprotease HBA75_27840 ENOG4105BZU Histidine kinase HBA75_27845 ENOG4105KCT ABC transporter HBA75_27850 ENOG4108M15 ABC transporter HBA75_27855 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HBA75_27865 ENOG4105IIU Aminopeptidase HBA75_27880 ENOG4105DU6 RNA polymerase HBA75_27890 ENOG410684U Domain of unknown function (DUF1934) HBA75_27910 ENOG4105CYW agmatinase HBA75_27920 ENOG4105DXB Major Facilitator superfamily HBA75_27925 ENOG4107SWG transcriptional regulator MERR family HBA75_27930 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HBA75_27935 ENOG4105BZ4 penicillin-binding protein HBA75_27940 ENOG4108XFG YwhD family HBA75_27945 ENOG4108Z4T Peptidase M50 HBA75_27950 ENOG41069HH 4-oxalocrotonate tautomerase HBA75_27955 ENOG4105DCI Phosphohydrolase HBA75_27960 ENOG4108MES Periplasmic binding protein HBA75_27965 ENOG4105E0A ABC, transporter HBA75_27970 ENOG4105EHG Permease protein HBA75_27975 ENOG4105DQ5 transport system permease protein HBA75_27985 ENOG4108VCI transcription factor, rsfa family HBA75_27990 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HBA75_27995 ENOG4108IJ2 phosphate acetyltransferase HBA75_28010 ENOG4108VKI Cell wall hydrolase HBA75_28035 ENOG4107SVH Potassium channel protein HBA75_28045 ENOG410667J hydrolase HBA75_28050 ENOG4105VCH membrane HBA75_28060 ENOG4108TU7 Inherit from COG: (ABC) transporter HBA75_28065 ENOG4105CJ1 ABC, transporter HBA75_28070 ENOG41090WU lipolytic protein G-D-S-L family HBA75_28085 ENOG4105D6E homoserine dehydrogenase HBA75_28110 ENOG4108Y4K DNA-binding transcriptional activator HBA75_28120 ENOG4105WH1 Two component transcriptional regulator luxr family HBA75_28125 ENOG4105BZU Histidine kinase HBA75_28130 ENOG4105DWF phosphomethylpyrimidine kinase HBA75_28135 ENOG4105BZU Histidine kinase HBA75_28140 ENOG4105VCD cytoplasmic protein HBA75_28145 ENOG4105D22 carbon starvation protein HBA75_28150 ENOG4105DY9 regulatoR HBA75_28155 ENOG41079KZ Major Facilitator Superfamily HBA75_28165 ENOG4105CG5 Glycosyl transferase (Group 1 HBA75_28175 ENOG4105EN6 Membrane HBA75_28180 ENOG4106YBV Methyl-accepting chemotaxis HBA75_28190 ENOG4108S4H thioesterase Superfamily protein HBA75_28195 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HBA75_28205 ENOG4105K64 Glycosyl transferase, family 2 HBA75_28225 ENOG4105CKK Glycosyl transferase, family 2 HBA75_28230 ENOG4105C5H ABC transporter HBA75_28235 ENOG41067SE Tetr family transcriptional regulator HBA75_28245 ENOG4105E0X reductase HBA75_28250 ENOG4106F5Q Membrane HBA75_28265 ENOG4108NEV two component transcriptional regulator, LytTR family HBA75_28270 ENOG4108HRK Histidine kinase HBA75_28275 ENOG4107RGD Major Facilitator superfamily HBA75_28290 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HBA75_28300 ENOG4105IW1 AmiS UreI transporter HBA75_28305 ENOG4105CMR udp-glucose 4-epimerase HBA75_28310 ENOG4108UT2 hemolysin iii HBA75_28320 ENOG4105C1J atp-dependent rna helicase HBA75_28325 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) HBA75_28330 ENOG4105DPN Oligoendopeptidase f HBA75_28350 ENOG4105DQ6 Transposase HBA75_28365 ENOG4105BZU Histidine kinase HBA75_28370 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HBA75_28380 ENOG4105C0H protease HBA75_28385 ENOG4105Q2H domain protein HBA75_28400 ENOG4105BZU Histidine kinase HBA75_28405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_28430 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HBA75_28435 ENOG4105CDU Replicative dna helicase HBA75_28445 ENOG4105BZR domain protein HBA75_28450 ENOG4108XMW Membrane HBA75_28460 ENOG4108UUM single-stranded DNA-binding protein HBA75_28470 ENOG4105C3G gtp-binding protein HBA75_28475 ENOG4105VDK protein, conserved in bacteria HBA75_28480 ENOG4105D8X mechanosensitive ion channel HBA75_28485 ENOG4108ZDA Sporulation protein YyaC HBA75_28490 ENOG4105FA0 parb-like partition protein HBA75_28495 ENOG4107QJE Chromosome Partitioning Protein HBA75_28510 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HBA75_28515 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HBA75_28525 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HBA75_28540 ENOG4105C0W non-ribosomal peptide synthetase HBA75_28540 ENOG4105C0W non-ribosomal peptide synthetase HBA75_28560 ENOG4105C1G acyl-Coa dehydrogenase HBA75_28575 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HBA75_28580 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) HBA75_28585 ENOG4105C1G acyl-Coa dehydrogenase HBA75_28595 ENOG4105C0W non-ribosomal peptide synthetase HBA75_28600 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HBA75_28605 ENOG4105IBP Cyclic peptide transporter HBA75_28650 ENOG4105TRI Hydrolase HBA75_28675 ENOG41067FT ParB-like nuclease domain HBA75_28695 ENOG4105BZ1 (ABC) transporter HBA75_28700 ENOG4105CJ1 ABC, transporter HBA75_28735 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_28790 ENOG4105CZV ABC transporter HBA75_28800 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HBA75_28805 ENOG4105BZ1 (ABC) transporter HBA75_28815 ENOG4107EXU Short-chain dehydrogenase reductase Sdr HBA75_28855 ENOG4105DQ6 Transposase HBA75_28880 ENOG4108M1A Chitin-binding protein HBA75_28900 ENOG4105D7V transposase HBA75_28925 ENOG4105E1K spore germination protein HBA75_28935 ENOG4108M1A Chitin-binding protein HBA75_28940 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C HBA75_28950 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HBA75_28975 ENOG4105BZU Histidine kinase HBA75_28980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HBA75_28990 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HBA75_29015 ENOG4107Y80 Major Facilitator superfamily HBA75_29040 ENOG4105CEY Amp-dependent synthetase and ligase HBA75_29045 ENOG4108VGI doxx family HBA75_29065 ENOG4105DUX Transporter HBA75_29085 ENOG4105F6J Alpha beta hydrolase fold HBA75_29095 ENOG410836F Transposase HBA75_29140 ENOG4105CJ1 ABC, transporter HBA75_29175 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) HBA75_29240 ENOG4105C19 ABC transporter HBA75_29330 ENOG4105DRR Transcriptional regulator, GntR family HBA75_29355 ENOG4107QHE Choloylglycine hydrolase HBA75_29380 ENOG4105MZU cell filamentation protein HBA75_29395 ENOG4105DVH amino acid HBA75_29415 ENOG4108UIN ybak prolyl-trna synthetase associated region HBA75_29430 ENOG4105JAB phenazine biosynthesis protein, phzf family HBA75_29440 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HBA75_29465 ENOG4107XGZ Hydrolase HBA75_29470 ENOG4105E98 transcriptional regulator DeoR family HBA75_29475 ENOG4105D7V transposase HBA75_29645 ENOG4105EKQ RNA-directed DNA polymerase HBA75_29655 ENOG4105EKQ RNA-directed DNA polymerase HBA75_29670 ENOG4105EKQ RNA-directed DNA polymerase HBA75_29675 ENOG4105CNU cell division protein FtsK HBA75_29815 ENOG4107JM4 Tetratricopeptide repeat HBA75_29830 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HBA75_29835 ENOG4105M6F mutator MutT protein HBA75_29840 ENOG4108WZA zeta toxin HBA75_29880 ENOG4108V2W Carbonate dehydratase HBA75_29885 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HBA75_29915 ENOG4105KMT branched-chain amino acid HBA75_29920 ENOG4108UMN azlc family HBA75_29925 ENOG4107U9B transcriptional regulator HBA75_29960 ENOG41065S2 pneumococcal vaccine antigen HBA75_29965 ENOG4105DR5 peptidase HBA75_29970 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_29985 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HBA75_30065 ENOG4108TTB tellurium resistance protein HBA75_30070 ENOG4107TS3 membrane protein, TerC HBA75_30075 ENOG4106FN3 tellurium resistance protein HBA75_30080 ENOG4106FN3 tellurium resistance protein HBA75_30085 ENOG4108N0M stress protein HBA75_30090 ENOG41066F8 ROK family HBA75_30100 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HBA75_30115 ENOG4105DEU major facilitator superfamily HBA75_30130 ENOG41062JF Transcriptional regulator HBA75_30170 ENOG4105D2X ABC transporter substrate-binding protein HBA75_30175 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HBA75_30195 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HBA75_30210 ENOG4105C9U ATP-dependent DNA helicase RecQ HBA75_30225 ENOG4105CI1 PTS System HBA75_30235 ENOG4105DNP FAD linked oxidase domain protein HBA75_30250 ENOG4108W63 CRP FNR family transcriptional regulator HBA75_30255 ENOG4105C5B carbamate kinase HBA75_30265 ENOG4105DBV ornithine carbamoyltransferase HBA75_30285 ENOG4105C8Q Methyl-accepting chemotaxis HBA75_30295 ENOG4105EAB amino acid AbC transporter HBA75_30300 ENOG4105E5Q amino acid AbC transporter HBA75_30325 ENOG4105D2S major facilitator superfamily HBA75_30330 ENOG410756H nucleotidyltransferase HBA75_30350 ENOG4105BZU Histidine kinase HBA75_30365 ENOG4106UIA HBA75_30370 ENOG4106UIA HBA75_30390 ENOG4108V5C ABC transporter HBA75_30395 ENOG4105DQ5 transport system permease protein HBA75_30400 ENOG4105EHG Permease protein HBA75_30420 ENOG4105D3R alkyl hydroperoxide reductase HBA75_30440 ENOG4105DFD Na H antiporter HBA75_30450 ENOG4105DTQ mandelate racemase muconate lactonizing HBA75_30465 ENOG4108W15 Protein of unknown function (DUF1456) HBA75_30475 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HBA75_30485 ENOG41085W3 Transposase HBA75_30645 ENOG4108JUB Transcriptional regulator HBA75_30655 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HBA75_30660 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HBA75_30695 ENOG4105UPD Calcium Proton HBA75_30700 ENOG410606W general stress protein HBA75_30710 ENOG4105DQ6 Transposase HBA75_30730 ENOG4107ZTW SNARE associated Golgi HBA75_30740 ENOG4105C3F Signal peptidase i HBA75_30750 ENOG4108IPJ Membrane HBA75_30755 ENOG4105C59 p-type ATPase HBA75_30760 ENOG4107U9T Pfam:Ribonuclease_BN HBA75_30770 ENOG4105KJF protein tyrosine phosphatase HBA75_30785 ENOG4105DQ6 Transposase HBA75_30800 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HBA75_31040 ENOG4105DQ6 Transposase HBA75_31050 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)