locus-tag class description FHE73_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FHE73_00015 ENOG410848D S4 domain protein YaaA FHE73_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHE73_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FHE73_00080 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FHE73_00100 ENOG4105ZMH deoxynucleoside kinase FHE73_00110 ENOG4105GTG Isochorismatase FHE73_00120 ENOG4108Z6B deaminase FHE73_00130 ENOG4105C6E dna polymerase iii FHE73_00150 ENOG41067KS pro-sigma K processing FHE73_00185 ENOG4105CXN decarboxylase FHE73_00195 ENOG4105FA2 dna polymerase iii FHE73_00200 ENOG4105MA4 psp1 domain protein FHE73_00210 ENOG41060K3 Methyltransferase FHE73_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FHE73_00225 ENOG4105KRN Transcriptional regulator, abrb family FHE73_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FHE73_00235 ENOG4105F8V Hydrolase, tatD family FHE73_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FHE73_00250 ENOG4105XFA sporulation peptidase YabG FHE73_00255 ENOG4105W42 Veg protein FHE73_00270 ENOG4105DFT pur operon repressor FHE73_00275 ENOG4105KME endoribonuclease L-psp FHE73_00290 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FHE73_00295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FHE73_00305 ENOG4108JA2 transcriptioN-repair coupling factor FHE73_00310 ENOG4108M14 stage v sporulation protein t FHE73_00320 ENOG4108IY2 MazG family FHE73_00325 ENOG41082I2 s4 domain protein FHE73_00330 ENOG4105VYY sporulation protein yabp FHE73_00345 ENOG41060GV RNA binding s1 domain protein FHE73_00365 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FHE73_00370 ENOG4108UGV hypoxanthine phosphoribosyltransferase FHE73_00375 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FHE73_00390 ENOG4105C6T cysteine synthase FHE73_00395 ENOG4105CRQ synthase (Component I) FHE73_00400 ENOG4105DDQ anthranilate synthase FHE73_00405 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FHE73_00410 ENOG4105EEI dihydropteroate synthase FHE73_00415 ENOG4105KRF dihydroneopterin aldolase FHE73_00420 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FHE73_00430 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FHE73_00580 ENOG4108Z0C Uvrb UvrC protein FHE73_00595 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FHE73_00605 ENOG4105CTP PilT protein domain protein FHE73_00610 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FHE73_00625 ENOG4105D7W serine acetyltransferase FHE73_00640 ENOG4105C2N RNA methyltransferase TrmH family group 3 FHE73_00645 ENOG4105M0M Tetracycline resistance protein FHE73_00650 ENOG4105QIV RNA polymerase FHE73_00665 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FHE73_00690 ENOG4107Y49 methyltransferase FHE73_00705 ENOG4105XPM ribosomal protein FHE73_00815 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FHE73_00840 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FHE73_00850 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FHE73_00860 ENOG41067V7 50S ribosomal protein L36 FHE73_00890 ENOG4108JJB ABC transporter FHE73_00895 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FHE73_00900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FHE73_00925 ENOG4105D1F ATP-binding protein FHE73_00940 ENOG4108NMV polysaccharide deacetylase FHE73_01020 ENOG4105C8B TIGR00159 family FHE73_01025 ENOG4107U5W ybbr family FHE73_01040 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FHE73_01065 ENOG4108PSK reductase FHE73_01070 ENOG4108UMI ABC transporter, permease FHE73_01075 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FHE73_01080 ENOG4105D01 (LipO)protein FHE73_01085 ENOG4105CB2 alcohol dehydrogenase FHE73_01095 ENOG4105IQ5 FAD linked oxidase domain protein FHE73_01110 ENOG4105C2C drug resistance transporter, Bcr CflA FHE73_01135 ENOG4105U5Y Transcriptional regulator FHE73_01145 ENOG4108J59 Extracellular solute-binding protein, family 5 FHE73_01150 ENOG4108J59 Extracellular solute-binding protein, family 5 FHE73_01170 ENOG4105E0C molybdate abc transporter FHE73_01175 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FHE73_01180 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FHE73_01190 ENOG4105EGI Transcriptional regulator FHE73_01210 ENOG4105F6E Acyl-transferase FHE73_01230 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FHE73_01250 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FHE73_01270 ENOG4105C5H ABC transporter FHE73_01275 ENOG4105BZU Histidine kinase FHE73_01280 ENOG4105WH1 Two component transcriptional regulator luxr family FHE73_01285 ENOG4105CJ1 ABC, transporter FHE73_01290 ENOG41090VJ ABC-2 type transporter FHE73_01295 ENOG4108KYE ABC-2 type transporter FHE73_01305 ENOG4105DEF Extracellular solute-binding protein, family 5 FHE73_01315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHE73_01320 ENOG4105C3U ABC transporter FHE73_01325 ENOG4108JQ7 (ABC) transporter FHE73_01330 ENOG410667J hydrolase FHE73_01360 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FHE73_01365 ENOG4105ERH Fumarylacetoacetate hydrolase FHE73_01380 ENOG4105CUB amino acid FHE73_01385 ENOG4108SC4 )-transporter FHE73_01390 ENOG4105CPF Cell wall formation (By similarity) FHE73_01395 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FHE73_01420 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FHE73_01425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FHE73_01435 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FHE73_01540 ENOG4105K8N protein family UPF0079, ATPase FHE73_01545 ENOG41072GX Peptidase M22 Glycoprotease FHE73_01550 ENOG410801F ribosomal-protein-alanine acetyltransferase FHE73_01555 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FHE73_01560 ENOG4105C5H ABC transporter FHE73_01575 ENOG4108TYN CAAX amino terminal protease family protein FHE73_01595 ENOG4105C7N Xanthine uracil vitamin C permease FHE73_01605 ENOG4105BZU Histidine kinase FHE73_01630 ENOG4107ZXU DSBA oxidoreductase FHE73_01660 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FHE73_01680 ENOG4108SHN Glycosyl transferase, family 2 FHE73_01725 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHE73_01745 ENOG4105SX7 Transporter FHE73_01775 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FHE73_01780 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FHE73_01785 ENOG4105C83 adenylosuccinate lyase FHE73_01795 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FHE73_01820 ENOG4108V3E phosphoribosylglycinamide formyltransferase FHE73_01825 ENOG4105DC1 bifunctional purine biosynthesis protein purh FHE73_01830 ENOG4105C12 Phosphoribosylglycinamide synthetase FHE73_01860 ENOG4105C4R Atp-dependent dna helicase FHE73_01865 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FHE73_01885 ENOG4108W2Y isochorismatase FHE73_01895 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FHE73_01900 ENOG4108UMI ABC transporter, permease FHE73_01905 ENOG4105D01 (LipO)protein FHE73_01925 ENOG410834F Transcriptional regulator FHE73_01930 ENOG4107I77 yiaA/B two helix domain FHE73_01940 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FHE73_01950 ENOG4105CBD Diacylglycerol kinase FHE73_01960 ENOG4108JPW Aminotransferase FHE73_01970 ENOG4105C26 Dehydrogenase FHE73_01975 ENOG4105KPY Small multidrug resistance protein FHE73_02000 ENOG4105D9N nucleoside FHE73_02005 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FHE73_02015 ENOG4108W15 Protein of unknown function (DUF1456) FHE73_02035 ENOG4105DTQ mandelate racemase muconate lactonizing FHE73_02045 ENOG4105DFD Na H antiporter FHE73_02070 ENOG4105D3R alkyl hydroperoxide reductase FHE73_02075 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FHE73_02080 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FHE73_02085 ENOG4107W7X Aldolase FHE73_02090 ENOG4105EHG Permease protein FHE73_02095 ENOG4105DQ5 transport system permease protein FHE73_02100 ENOG4108V5C ABC transporter FHE73_02110 ENOG4105CAY ferredoxin--nadp reductase FHE73_02130 ENOG4106UIA FHE73_02135 ENOG4106UIA FHE73_02150 ENOG4105BZU Histidine kinase FHE73_02170 ENOG410756H nucleotidyltransferase FHE73_02175 ENOG4105D2S major facilitator superfamily FHE73_02190 ENOG4105E5Q amino acid AbC transporter FHE73_02195 ENOG4105EAB amino acid AbC transporter FHE73_02205 ENOG4105C8Q Methyl-accepting chemotaxis FHE73_02220 ENOG4105DBV ornithine carbamoyltransferase FHE73_02230 ENOG4105C5B carbamate kinase FHE73_02235 ENOG4108W63 CRP FNR family transcriptional regulator FHE73_02250 ENOG4105CI1 PTS System FHE73_02265 ENOG4105C9U ATP-dependent DNA helicase RecQ FHE73_02280 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FHE73_02300 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FHE73_02305 ENOG4105D2X ABC transporter substrate-binding protein FHE73_02350 ENOG41062JF Transcriptional regulator FHE73_02365 ENOG4105DEU major facilitator superfamily FHE73_02380 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FHE73_02395 ENOG4108N0M stress protein FHE73_02400 ENOG4106FN3 tellurium resistance protein FHE73_02405 ENOG4106FN3 tellurium resistance protein FHE73_02410 ENOG4107TS3 membrane protein, TerC FHE73_02415 ENOG4108TTB tellurium resistance protein FHE73_02430 ENOG41068PA UPF0435 protein FHE73_02435 ENOG4105KJF protein tyrosine phosphatase FHE73_02445 ENOG4107U9T Pfam:Ribonuclease_BN FHE73_02450 ENOG4105C59 p-type ATPase FHE73_02455 ENOG4108IPJ Membrane FHE73_02475 ENOG4107ZTW SNARE associated Golgi FHE73_02490 ENOG410606W general stress protein FHE73_02495 ENOG4105UPD Calcium Proton FHE73_02535 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FHE73_02545 ENOG4108JUB Transcriptional regulator FHE73_02555 ENOG4108IQI permease FHE73_02595 ENOG4108A04 Beta-lactamase FHE73_02610 ENOG4105CKK Glycosyl transferase, family 2 FHE73_02615 ENOG4107QQG Dehydrogenase FHE73_02620 ENOG4105C3I Nad-dependent epimerase dehydratase FHE73_02635 ENOG4105F1A Pyruvate formate-lyase FHE73_02650 ENOG4108QBV Monogalactosyldiacylglycerol synthase FHE73_02665 ENOG4105CI2 imidazolone-5-propionate hydrolase FHE73_02670 ENOG4105ECP epimerase FHE73_02700 ENOG41067AE Membrane-bound metal-dependent hydrolase FHE73_02705 ENOG4105CEN a g-specific adenine glycosylase FHE73_02710 ENOG4106BXE FHE73_02730 ENOG4105BZ1 (ABC) transporter FHE73_02735 ENOG4107NBY Membrane FHE73_02740 ENOG4105CBC glutamate synthase FHE73_02750 ENOG4108IUW ABC transporter FHE73_02770 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHE73_02775 ENOG4105G5W regulator Fur family FHE73_02885 ENOG4105CDY transcriptional regulatory protein FHE73_02895 ENOG4108JQC penicillin-binding protein 1A FHE73_02900 ENOG4108R9S DSBA oxidoreductase FHE73_02910 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FHE73_02920 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FHE73_02930 ENOG4105CYN Serine protein kinase FHE73_02950 ENOG4105C94 Transporter FHE73_02965 ENOG4105DZ6 Band 7 protein FHE73_02975 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FHE73_02980 ENOG4108V9W transcriptional regulatory protein FHE73_02985 ENOG4105D4T Citrate transporter FHE73_03010 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FHE73_03015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FHE73_03020 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FHE73_03025 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FHE73_03030 ENOG4105BZ7 extracellular solute-binding protein family 1 FHE73_03035 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FHE73_03040 ENOG4108STX response regulator FHE73_03045 ENOG4105US7 Histidine kinase FHE73_03070 ENOG4108MRH transcriptional regulatory protein FHE73_03080 ENOG4105C6K Malic enzyme FHE73_03090 ENOG4108UZ3 Transporter FHE73_03095 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FHE73_03105 ENOG4105BZU Histidine kinase FHE73_03120 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FHE73_03125 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FHE73_03130 ENOG4108JB9 formate dehydrogenase FHE73_03150 ENOG4105CUB amino acid FHE73_03160 ENOG4105C59 p-type ATPase FHE73_03165 ENOG4105DAP Nicotinate phosphoribosyltransferase FHE73_03200 ENOG41073R8 VanW family FHE73_03205 ENOG4108KGH TRANSCRIPTIONal FHE73_03210 ENOG4105D9N nucleoside FHE73_03215 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FHE73_03220 ENOG4105C37 (CBS) domain FHE73_03225 ENOG4108IJ0 Aspartate ammonia-lyase FHE73_03230 ENOG4105DAA L-lactate FHE73_03245 ENOG4105DUX Transporter FHE73_03250 ENOG4108MES Periplasmic binding protein FHE73_03255 ENOG4105DQ5 transport system permease protein FHE73_03260 ENOG4108IHU transport system permease protein FHE73_03265 ENOG4105E0A ABC, transporter FHE73_03280 ENOG4105EXW epimerase dehydratase FHE73_03290 ENOG4107T89 von Willebrand factor, type A FHE73_03295 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FHE73_03300 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FHE73_03310 ENOG4105BZU Histidine kinase FHE73_03315 ENOG4105D5Q Arginine ornithine antiporter FHE73_03320 ENOG4107414 GntR family transcriptional regulator FHE73_03325 ENOG4105C5Y PTS System FHE73_03330 ENOG4105CG3 alpha amylase, catalytic region FHE73_03345 ENOG4105E1K spore germination protein FHE73_03350 ENOG4105CRN Aminoglycoside phosphotransferase FHE73_03355 ENOG4105BZG amino acid carrier protein FHE73_03365 ENOG4105CDA abc transporter atp-binding protein FHE73_03370 ENOG4105CT1 (ABC) transporter FHE73_03375 ENOG4105EAD ABC transporter FHE73_03380 ENOG4105DRP amino acid AbC transporter FHE73_03385 ENOG4108IQI permease FHE73_03400 ENOG4105GFR rna polymerase sigma factor FHE73_03410 ENOG4105D29 Helix-turn-helix type 11 domain protein FHE73_03415 ENOG4105NAE bifunctional deaminase-reductase domain protein FHE73_03420 ENOG4105BZU Histidine kinase FHE73_03435 ENOG4105CHH sulfate transporter FHE73_03440 ENOG41068KF Universal stress protein FHE73_03450 ENOG4105CXY transporter FHE73_03455 ENOG41067TZ transcriptional regulator, MarR family FHE73_03460 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHE73_03465 ENOG4105ETE Transcriptional regulator (LacI family FHE73_03470 ENOG4108RVA ribokinase FHE73_03480 ENOG4105C2J ABC transporter FHE73_03485 ENOG4105CNN ABC, transporter FHE73_03490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FHE73_03495 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FHE73_03530 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) FHE73_03560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FHE73_03565 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FHE73_03570 ENOG41069ER domain protein FHE73_03575 ENOG4105VZ8 Transcriptional regulator FHE73_03580 ENOG4107D63 FHE73_03595 ENOG4105DUX Transporter FHE73_03615 ENOG4105C85 amino acid FHE73_03620 ENOG4105C7N Xanthine uracil vitamin C permease FHE73_03635 ENOG4105MA6 gCN5-related N-acetyltransferase FHE73_03660 ENOG4105BZ9 Cytochrome C oxidase, subunit I FHE73_03665 ENOG4105E2S oxidase) subunit II FHE73_03685 ENOG4106CAD Protein of unknown function (DUF3311) FHE73_03690 ENOG4105E1V na solute symporter FHE73_03705 ENOG4108NHD germination protein FHE73_03710 ENOG4105CE1 Ferrous iron transport protein b FHE73_03715 ENOG4105CE1 Ferrous iron transport protein b FHE73_03720 ENOG4105CE1 Ferrous iron transport protein b FHE73_03725 ENOG4105CVA phosphate FHE73_03730 ENOG4105C8U phosphate abc transporter FHE73_03735 ENOG4105E2Z phosphate ABC transporter (Permease FHE73_03865 ENOG41080XQ Signal transduction protein with cbs domains FHE73_03885 ENOG4105ETU transcriptional activator (TenA FHE73_03895 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FHE73_03905 ENOG4108VEU Thiamine monophosphate synthase FHE73_03910 ENOG41080HI glycine oxidase FHE73_03925 ENOG4105D06 uba thif-type nad fad binding protein FHE73_03930 ENOG4105DWF phosphomethylpyrimidine kinase FHE73_03980 ENOG4108INS Transcriptional regulator FHE73_03995 ENOG4105C7N Xanthine uracil vitamin C permease FHE73_04005 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FHE73_04025 ENOG4105C5Y PTS System FHE73_04040 ENOG4105K63 Thioredoxin FHE73_04060 ENOG4108B31 Spore germination protein FHE73_04080 ENOG4107Y03 Nitroreductase FHE73_04085 ENOG4105ED1 spovr family FHE73_04095 ENOG4108TCS Glutamyl endopeptidase FHE73_04105 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FHE73_04110 ENOG4105XTG Pfam:DUF156 FHE73_04115 ENOG4105VFE sira family FHE73_04120 ENOG4107TPS domain protein FHE73_04125 ENOG4105VFE sira family FHE73_04130 ENOG4105VFE sira family FHE73_04135 ENOG41085GJ domain protein FHE73_04140 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FHE73_04145 ENOG41087NI Sulfite exporter TauE/SafE FHE73_04155 ENOG4108KGH TRANSCRIPTIONal FHE73_04185 ENOG4105EMD TRANSCRIPTIONal FHE73_04190 ENOG4105VCP PTS System FHE73_04195 ENOG4105VZJ PTS System FHE73_04220 ENOG41069ER domain protein FHE73_04225 ENOG4107RBB ABC transporter, permease FHE73_04230 ENOG4105C19 ABC transporter FHE73_04265 ENOG4105WEF catalase FHE73_04300 ENOG4107T5V SNARE associated Golgi FHE73_04330 ENOG4105CUB amino acid FHE73_04335 ENOG4107RWR Sodium hydrogen exchanger FHE73_04345 ENOG4106KNT transcriptional regulator FHE73_04385 ENOG4108YXU transcriptional regulator AsnC family FHE73_04395 ENOG4105KPY Small multidrug resistance protein FHE73_04415 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FHE73_04420 ENOG410605W Major Facilitator FHE73_04430 ENOG4107RKG DJ-1/PfpI family FHE73_04435 ENOG4105CH6 catalase FHE73_04445 ENOG4105D5Q Arginine ornithine antiporter FHE73_04450 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FHE73_04460 ENOG4105C26 Dehydrogenase FHE73_04475 ENOG4105BZ1 (ABC) transporter FHE73_04480 ENOG4105BZ1 (ABC) transporter FHE73_04495 ENOG4105DRP amino acid AbC transporter FHE73_04500 ENOG4105CDA abc transporter atp-binding protein FHE73_04515 ENOG410839P FHE73_04550 ENOG4107FQX Alpha-acetolactate decarboxylase FHE73_04575 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FHE73_04580 ENOG4105D4P Coproporphyrinogen iii oxidase FHE73_04585 ENOG4105CEY Amp-dependent synthetase and ligase FHE73_04600 ENOG4105CHH sulfate transporter FHE73_04625 ENOG4105CGU Enoyl-CoA hydratase FHE73_04645 ENOG4105DER m42 family FHE73_04670 ENOG4105CIF Ornithine Cyclodeaminase FHE73_04690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHE73_04695 ENOG4105C3U ABC transporter FHE73_04700 ENOG4108JQ7 (ABC) transporter FHE73_04755 ENOG4108IBT Inherit from COG: transposase FHE73_04790 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) FHE73_04850 ENOG4105CSH Transporter FHE73_04860 ENOG4108MRH transcriptional regulatory protein FHE73_04910 ENOG4105CDU Replicative dna helicase FHE73_04930 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHE73_05060 ENOG4107P5I polyketide synthase FHE73_05065 ENOG4108IG5 Transcriptional regulator FHE73_05080 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FHE73_05100 ENOG4105CMT Dihydroxyacetone kinase FHE73_05115 ENOG4105CMT Dihydroxyacetone kinase FHE73_05130 ENOG410780I phosphoprotein phosphatase activity FHE73_05160 ENOG41069ER domain protein FHE73_05195 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FHE73_05280 ENOG4105WN5 stage II sporulation protein FHE73_05290 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHE73_05300 ENOG4108MJI response regulator FHE73_05305 ENOG4105BZU Histidine kinase FHE73_05310 ENOG4105BZU Histidine kinase FHE73_05330 ENOG4105K8R UPF0145 protein FHE73_05340 ENOG4105D7V transposase FHE73_05350 ENOG4105ENE Histidine kinase FHE73_05355 ENOG4108VB1 regulatoR FHE73_05380 ENOG4107VRP DNA repair exonuclease FHE73_05385 ENOG4106D4I domain protein FHE73_05395 ENOG4105ED2 Beta-lactamase FHE73_05420 ENOG4108MUZ hydrolase FHE73_05440 ENOG4105F0F Oxalate decarboxylase FHE73_05445 ENOG41067QW Transcriptional regulator FHE73_05450 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FHE73_05465 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FHE73_05475 ENOG4105EMN RNA polymerase sigma factor FHE73_05490 ENOG4105EEM helicase FHE73_05500 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FHE73_05530 ENOG4105K59 histidine triad (HIT) protein FHE73_05560 ENOG410905X membrane-flanked domain protein FHE73_05565 ENOG4105CKV Membrane FHE73_05605 ENOG410905X membrane-flanked domain protein FHE73_05615 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FHE73_05620 ENOG4105BZ4 penicillin-binding protein FHE73_05630 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FHE73_05635 ENOG4105C1Q protoporphyrinogen oxidase FHE73_05660 ENOG4105NA0 Transcriptional regulator FHE73_05675 ENOG4105ECB domain protein FHE73_05695 ENOG4108MK9 spermidine N(1)-acetyltransferase FHE73_05705 ENOG4106AXD FHE73_05710 ENOG4108RQ5 Beta-lactamase domain-containing protein FHE73_05715 ENOG4105DF9 Lipoate-protein, ligase FHE73_05730 ENOG4105CEY Amp-dependent synthetase and ligase FHE73_05750 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FHE73_05760 ENOG4107RN3 metallophosphoesterase FHE73_05765 ENOG4107TVP HD domain protein FHE73_05775 ENOG4108AEY RNA polymerase sigma factor FHE73_05785 ENOG41086D8 Transcriptional regulator FHE73_05795 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHE73_05815 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FHE73_05820 ENOG4105C8Q Methyl-accepting chemotaxis FHE73_05825 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) FHE73_05835 ENOG4107QP3 malate synthase g FHE73_05855 ENOG4105VEQ Cold shock protein FHE73_05895 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FHE73_05900 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FHE73_05940 ENOG4105ERH Fumarylacetoacetate hydrolase FHE73_05950 ENOG4105C8Y Acetylornithine aminotransferase FHE73_05965 ENOG4105CAQ asparagine synthetase FHE73_05970 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FHE73_05975 ENOG4105CH6 catalase FHE73_05980 ENOG4105BZU Histidine kinase FHE73_06000 ENOG4108VPT UPF0234 protein FHE73_06005 ENOG4105QNR S1 RNA binding domain protein FHE73_06010 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FHE73_06020 ENOG4107AYK membrAne FHE73_06025 ENOG41073B9 FHE73_06035 ENOG4108KP7 hydrolase FHE73_06045 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FHE73_06070 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FHE73_06075 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FHE73_06090 ENOG4105C31 Tryptophanyl-tRNA synthetase FHE73_06110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FHE73_06115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHE73_06125 ENOG4108JQ7 (ABC) transporter FHE73_06135 ENOG4105UQX Mate efflux family protein FHE73_06160 ENOG4108ZCF integral membrane protein FHE73_06170 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FHE73_06180 ENOG4105DPN Oligoendopeptidase f FHE73_06190 ENOG4108Z18 K06886 hemoglobin FHE73_06195 ENOG4105MIX Adenylate cyclase FHE73_06200 ENOG4106EFP UPF0738 protein FHE73_06210 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FHE73_06215 ENOG4105EMS pseudouridine synthase FHE73_06235 ENOG4105K64 Glycosyl transferase, family 2 FHE73_06255 ENOG4107TVC Glycosyl transferase, family 2 FHE73_06275 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FHE73_06280 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FHE73_06290 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FHE73_06345 ENOG4108ZMI UPF0477 protein FHE73_06370 ENOG4105CK7 Sodium proline symporter FHE73_06380 ENOG4105CRQ synthase (Component I) FHE73_06385 ENOG4105DDQ anthranilate synthase FHE73_06410 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FHE73_06480 ENOG4105C7S Dehydrogenase FHE73_06490 ENOG4105VZ8 Transcriptional regulator FHE73_06590 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHE73_06620 ENOG4105DZR Type I site-specific deoxyribonuclease FHE73_06650 ENOG4105VTR Integrase FHE73_06675 ENOG4105DZ1 carboxypeptidase FHE73_06680 ENOG4105VFR signal peptidase FHE73_06715 ENOG4105C26 Dehydrogenase FHE73_06720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FHE73_06725 ENOG4105F38 ABC transporter, permease FHE73_06730 ENOG4105D38 putrescine abc transporter FHE73_06735 ENOG4107RUE extracellular solute-binding protein family 1 FHE73_06745 ENOG4105EYF MMPL domain protein FHE73_06755 ENOG4108YBP pseudouridine synthase FHE73_06765 ENOG4105K4I Scp-like extracellular FHE73_06770 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FHE73_06775 ENOG4105CQB FAD linked oxidase domain protein FHE73_06790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_06795 ENOG4105BZU Histidine kinase FHE73_06800 ENOG4105JXH GntR family transcriptional regulator FHE73_06820 ENOG4106A3R peptidase FHE73_06830 ENOG4108QTI )-transporter FHE73_06835 ENOG4107TS3 membrane protein, TerC FHE73_06840 ENOG4105CZN Potassium uptake protein FHE73_06845 ENOG410681C small acid-soluble spore protein FHE73_06850 ENOG4108Z7G MaoC domain protein dehydratase FHE73_06870 ENOG4105CHR reductase FHE73_06875 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class FHE73_06900 ENOG4105C4Y ABC transporter FHE73_06905 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FHE73_06910 ENOG4107RCV ABC transporter, permease FHE73_06930 ENOG4105E98 transcriptional regulator DeoR family FHE73_06940 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FHE73_06950 ENOG4105PXI polysaccharide deacetylase FHE73_06960 ENOG4105BZU Histidine kinase FHE73_06965 ENOG41090MY MarR family Transcriptional regulator FHE73_06975 ENOG4106DF1 FHE73_06980 ENOG4105BZU Histidine kinase FHE73_06985 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FHE73_06990 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FHE73_06995 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FHE73_07035 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FHE73_07040 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FHE73_07045 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FHE73_07050 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FHE73_07055 ENOG4105CZV ABC transporter FHE73_07065 ENOG4105CJ1 ABC, transporter FHE73_07105 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FHE73_07110 ENOG4105EA8 2-Nitropropane dioxygenase FHE73_07115 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FHE73_07125 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FHE73_07145 ENOG4105NQC Flavodoxin FHE73_07175 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FHE73_07210 ENOG4105CZN Potassium uptake protein FHE73_07215 ENOG41063Y9 FHE73_07220 ENOG4105KBJ sporulation protein ytfj FHE73_07240 ENOG4105CM2 brancheD-chain amino acid aminotransferase FHE73_07245 ENOG4105C7K acetolactate synthase FHE73_07250 ENOG4108ZP8 Acetolactate synthase small subunit FHE73_07255 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FHE73_07270 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FHE73_07285 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FHE73_07290 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FHE73_07295 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FHE73_07300 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FHE73_07305 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FHE73_07310 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FHE73_07325 ENOG4107RVV histidinol phosphate phosphatase, hisj family FHE73_07340 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FHE73_07345 ENOG4105E0M Sulfatase FHE73_07355 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FHE73_07370 ENOG4107S4M Sulfate adenylate transferase FHE73_07375 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FHE73_07380 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FHE73_07390 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FHE73_07395 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FHE73_07400 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FHE73_07405 ENOG4105C8J )-transporter FHE73_07425 ENOG4105DFD Na H antiporter FHE73_07445 ENOG4105ENE Histidine kinase FHE73_07450 ENOG4105WH1 Two component transcriptional regulator luxr family FHE73_07470 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FHE73_07495 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FHE73_07515 ENOG4105CJ3 phosphate transporter FHE73_07520 ENOG4107GRR phosphate transport regulator FHE73_07525 ENOG4105BZ4 penicillin-binding protein FHE73_07540 ENOG4105BZU Histidine kinase FHE73_07545 ENOG4105I3N Conserved Protein FHE73_07560 ENOG4105BZU Histidine kinase FHE73_07590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FHE73_07595 ENOG4105DZ1 carboxypeptidase FHE73_07600 ENOG4108JIC nucleoside recognition domain protein FHE73_07610 ENOG4105FE9 pseudouridine synthase FHE73_07615 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHE73_07620 ENOG4107TWT Cytochrome c biogenesis protein FHE73_07625 ENOG4105CRE cytochrome C FHE73_07630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_07635 ENOG4105BZU Histidine kinase FHE73_07640 ENOG4108WBT adenosyltransferase FHE73_07655 ENOG4108SAX Membrane FHE73_07670 ENOG4105C9U ATP-dependent DNA helicase RecQ FHE73_07675 ENOG4105I7S Abortive infection protein FHE73_07685 ENOG4107RGJ metallophosphoesterase FHE73_07690 ENOG4108XDN Transcriptional regulator FHE73_07695 ENOG4108S6Z Negative regulator of genetic competence FHE73_07720 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FHE73_07725 ENOG4107RB3 L-asparaginase FHE73_07740 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FHE73_07755 ENOG4105S2F FHE73_07760 ENOG41065D1 FHE73_07790 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FHE73_07805 ENOG4105XXQ heptaprenyl diphosphate synthase component I FHE73_07815 ENOG4105EAH synthase FHE73_07820 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FHE73_07825 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FHE73_07845 ENOG41068YB TPR repeat-containing protein FHE73_07860 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FHE73_07865 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FHE73_07900 ENOG4108JYZ YitT family FHE73_07910 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FHE73_07925 ENOG4105FJR Lmbe family FHE73_07930 ENOG4105CPK Glycosyl transferase (Group 1 FHE73_07945 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FHE73_07960 ENOG4105DVT helicase FHE73_07965 ENOG4105YAC FHE73_07985 ENOG4105CSM endonuclease III FHE73_07995 ENOG4105BZ4 penicillin-binding protein FHE73_08050 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FHE73_08060 ENOG4105DVT helicase FHE73_08065 ENOG4105CTD carboxy-peptidase FHE73_08075 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FHE73_08080 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FHE73_08085 ENOG4105C2W permease FHE73_08090 ENOG4105DHF Membrane FHE73_08095 ENOG410890F Dynamin family FHE73_08105 ENOG4108W0I acetyltransferase FHE73_08115 ENOG4105KHC sulfurtransferase FHE73_08140 ENOG4106032 Glutathionylspermidine synthase FHE73_08185 ENOG4105HTX biosynthesis protein FHE73_08215 ENOG4105CPK Glycosyl transferase (Group 1 FHE73_08250 ENOG41081VK Ribonuclease FHE73_08315 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FHE73_08325 ENOG4107RWR Sodium hydrogen exchanger FHE73_08330 ENOG4108Z5V transcriptional regulator, merr family FHE73_08340 ENOG4105H67 Protein of unknown function (DUF421) FHE73_08345 ENOG41080C8 DUF218 domain FHE73_08385 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FHE73_08395 ENOG4107R0U MotA TolQ exbB proton channel FHE73_08400 ENOG4105ER2 Ompa motb domain protein FHE73_08405 ENOG4107YTP response regulator receiver protein FHE73_08410 ENOG4105CBS Chea signal transduction histidine kinase FHE73_08415 ENOG4105DD5 Flagellar motor switch protein FHE73_08430 ENOG4105BZU Histidine kinase FHE73_08450 ENOG4105E1Q flagellar hook-associated protein FHE73_08455 ENOG4105DTJ flagellar hook-associated protein FHE73_08460 ENOG4107TPX flagellar hook-associated FHE73_08475 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FHE73_08480 ENOG4108ZC9 flagellar basal-body rod protein flgc FHE73_08485 ENOG41075Z6 flagellar hook-basal body complex protein fliE FHE73_08490 ENOG4107U2N Flagellar M-ring protein FHE73_08495 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FHE73_08525 ENOG4105BZE flagellar hook protein, FlgE FHE73_08540 ENOG4107R88 Chemotaxis protein (CheV) FHE73_08550 ENOG4105I03 Flagellin FHE73_08555 ENOG4105I03 Flagellin FHE73_08560 ENOG4105I03 Flagellin FHE73_08565 ENOG4105I03 Flagellin FHE73_08570 ENOG4105E4C Lytic transglycosylase catalytic FHE73_08580 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FHE73_08585 ENOG4105DD5 Flagellar motor switch protein FHE73_08595 ENOG4105CN7 Flagellar biosynthetic protein FliP FHE73_08600 ENOG4105VS8 Flagellar biosynthetic protein fliq FHE73_08610 ENOG4105D00 flagellar biosynthetic protein flhB FHE73_08615 ENOG4105D7B Flagellar biosynthesis protein flha FHE73_08620 ENOG4105FZW flagellar biosynthesis regulator FlhF FHE73_08625 ENOG4105KTQ flagellar basal-body rod protein FHE73_08630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FHE73_08665 ENOG4105KAC Antibiotic biosynthesis monooxygenase FHE73_08690 ENOG4105DUM transcriptional regulator, lysR family FHE73_08705 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FHE73_08740 ENOG4105CVJ phosphoglycerate mutase FHE73_08750 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FHE73_08770 ENOG4105CAQ asparagine synthetase FHE73_08790 ENOG4105PGM cation diffusion facilitator family transporter FHE73_08800 ENOG4105DRR Transcriptional regulator, GntR family FHE73_08805 ENOG4108UZ3 Transporter FHE73_08810 ENOG4105CKI cobalamin synthesis protein FHE73_08820 ENOG4108PJD permease FHE73_08835 ENOG4105DFD Na H antiporter FHE73_08840 ENOG4105VUF Transcriptional regulator FHE73_08850 ENOG4105C9Q fumarate hydratase class II FHE73_08865 ENOG4107QJQ Mate efflux family protein FHE73_08870 ENOG4105EC3 peptidase S51, dipeptidase E FHE73_08890 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHE73_08920 ENOG4106BRA Membrane FHE73_08960 ENOG4105CJ1 ABC, transporter FHE73_08980 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FHE73_08990 ENOG4108IJ0 Aspartate ammonia-lyase FHE73_08995 ENOG4105C6K Malic enzyme FHE73_09055 ENOG4105FVX FHE73_09060 ENOG4105E09 nadh pyrophosphatase FHE73_09080 ENOG4105CSR polyphosphate kinase 2 FHE73_09085 ENOG4105U3E Transcriptional regulator FHE73_09095 ENOG4105DXI Major Facilitator superfamily FHE73_09105 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FHE73_09110 ENOG4105EU0 Major facilitator Superfamily FHE73_09115 ENOG4105C6T cysteine synthase FHE73_09135 ENOG4105C8J )-transporter FHE73_09145 ENOG4105X5K response regulator receiver protein FHE73_09150 ENOG4105H67 Protein of unknown function (DUF421) FHE73_09165 ENOG4106KE4 Dehydrogenase FHE73_09180 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FHE73_09185 ENOG4105CHR reductase FHE73_09190 ENOG4105CM2 brancheD-chain amino acid aminotransferase FHE73_09195 ENOG4105C7K acetolactate synthase FHE73_09205 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FHE73_09215 ENOG4105C7B Threonine dehydratase FHE73_09240 ENOG4105C6X Major Facilitator FHE73_09245 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FHE73_09255 ENOG4105DY9 regulatoR FHE73_09260 ENOG4105CYC Transferase FHE73_09265 ENOG4105K5X acetyltransferase FHE73_09285 ENOG41068WN FHE73_09305 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FHE73_09320 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FHE73_09325 ENOG4105C0X amino acid FHE73_09350 ENOG4105K8R UPF0145 protein FHE73_09355 ENOG4108TYN CAAX amino terminal protease family protein FHE73_09370 ENOG4107RHR regulatoR FHE73_09380 ENOG4105D9N nucleoside FHE73_09385 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FHE73_09405 ENOG4108IBT Inherit from COG: transposase FHE73_09435 ENOG4107RAQ aminopeptidase FHE73_09445 ENOG4107R16 Multicopper oxidase FHE73_09495 ENOG4108T5E Copper resistance protein FHE73_09505 ENOG4107RT3 EamA-like transporter family FHE73_09510 ENOG4105GZI Transcriptional regulator FHE73_09515 ENOG4108Z40 Transcriptional regulator FHE73_09520 ENOG4107ZXU DSBA oxidoreductase FHE73_09525 ENOG4108TVJ Nitroreductase FHE73_09530 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FHE73_09535 ENOG4106F5Q Membrane FHE73_09540 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FHE73_09555 ENOG4105CKI cobalamin synthesis protein FHE73_09565 ENOG4105C0Z ABC transporter FHE73_09570 ENOG4108IV0 ABC, transporter FHE73_09575 ENOG4105C32 Amino acid ABC transporter (Permease) FHE73_09585 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family FHE73_09595 ENOG4105MDS 4-oxalocrotonate tautomerase FHE73_09615 ENOG4105C4M (Ubiquinol oxidase) subunit I FHE73_09620 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FHE73_09625 ENOG4108JJ9 ABC, transporter FHE73_09630 ENOG4108JJ8 (ABC) transporter FHE73_09640 ENOG4105K64 Glycosyl transferase, family 2 FHE73_09650 ENOG4108UT6 Transferase hexapeptide repeat containing protein FHE73_09705 ENOG4105BZ1 (ABC) transporter FHE73_09710 ENOG4105EFI regulatoR FHE73_09715 ENOG4105BZU Histidine kinase FHE73_09725 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FHE73_09730 ENOG4108ZJ4 polysaccharide deacetylase FHE73_09740 ENOG41081VB Hydrolase FHE73_09750 ENOG4105D6E homoserine dehydrogenase FHE73_09760 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FHE73_09775 ENOG4108KGH TRANSCRIPTIONal FHE73_09785 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHE73_09790 ENOG4105BZU Histidine kinase FHE73_09795 ENOG4107VMI polysaccharide deacetylase FHE73_09805 ENOG4105KT7 mgtC SapB transporter FHE73_09810 ENOG4105VRR gCN5-related N-acetyltransferase FHE73_09820 ENOG4105DUU IucA IucC family protein FHE73_09825 ENOG4105CEY Amp-dependent synthetase and ligase FHE73_09840 ENOG4108WBH protein TIM barrel FHE73_09845 ENOG4105YWU small acid-soluble spore protein FHE73_09855 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FHE73_09860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FHE73_09910 ENOG4105KRN Transcriptional regulator, abrb family FHE73_09920 ENOG4105YVS arsR family transcriptional regulator FHE73_09925 ENOG4105CPC Aldo Keto reductase FHE73_09930 ENOG4107XZQ multidrug resistance protein FHE73_09940 ENOG4105KAF membrAne FHE73_09965 ENOG4105C8Q Methyl-accepting chemotaxis FHE73_09980 ENOG4108K88 Membrane FHE73_09985 ENOG4108WPJ Ferritin-like domain FHE73_10000 ENOG4105DEN Luciferase family FHE73_10015 ENOG4105VMI -acetyltransferase FHE73_10020 ENOG4107QM2 Aldo Keto reductase FHE73_10025 ENOG4105CKI cobalamin synthesis protein FHE73_10035 ENOG4105DSE periplasmic solute binding protein FHE73_10040 ENOG4105K4T epimerase FHE73_10050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FHE73_10095 ENOG4107T5V SNARE associated Golgi FHE73_10110 ENOG4108PJD permease FHE73_10120 ENOG4108S4H thioesterase Superfamily protein FHE73_10130 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FHE73_10150 ENOG4105SXS Protein of unknown function (DUF456) FHE73_10155 ENOG4105C37 (CBS) domain FHE73_10180 ENOG4108Z7R Chaperone CsaA FHE73_10200 ENOG4108ZRV stage ii sporulation protein p FHE73_10210 ENOG4108VXD carboxy-peptidase FHE73_10240 ENOG4108ZRV stage ii sporulation protein p FHE73_10250 ENOG4108X4Q Hydrolase FHE73_10265 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FHE73_10280 ENOG41087PP glycosyltransferase MGT family FHE73_10285 ENOG4108JYZ YitT family FHE73_10320 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FHE73_10355 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) FHE73_10360 ENOG4108MGT Required for secretion of EsxA and EsxB FHE73_10420 ENOG4105KBJ sporulation protein ytfj FHE73_10445 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FHE73_10465 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FHE73_10470 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FHE73_10480 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FHE73_10485 ENOG4105EMN RNA polymerase sigma factor FHE73_10500 ENOG4105CNW domain protein FHE73_10510 ENOG4108V06 Glutathione peroxidase FHE73_10525 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FHE73_10535 ENOG4108IUE nitrate reductase beta subunit FHE73_10540 ENOG4105R3A Nitrate reductase FHE73_10550 ENOG4107V6Q Cyclic nucleotide-binding domain FHE73_10555 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FHE73_10560 ENOG4105D06 uba thif-type nad fad binding protein FHE73_10565 ENOG4105CVM Molybdenum cofactor synthesis domain protein FHE73_10570 ENOG4108ZAF Molybdopterin FHE73_10595 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FHE73_10600 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FHE73_10605 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FHE73_10610 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FHE73_10615 ENOG4108IFG nitrite reductase, (NAD(P)H) FHE73_10620 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FHE73_10640 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FHE73_10655 ENOG4105MCT stage V sporulation protein S FHE73_10720 ENOG4105C5H ABC transporter FHE73_10735 ENOG4108UUM single-stranded DNA-binding protein FHE73_10760 ENOG4107YX5 Pfam:DUF548 FHE73_10765 ENOG4105C75 arginyL-tRNA synthetase FHE73_10790 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FHE73_10810 ENOG4105C5S asparaginyl-tRNA synthetase FHE73_10815 ENOG4105C8J )-transporter FHE73_10820 ENOG4108EF6 Proline imino-peptidase FHE73_10835 ENOG4107XGZ Hydrolase FHE73_10840 ENOG4105CY2 Citrate transporter FHE73_10860 ENOG4105KD7 acetyltransferase FHE73_10865 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FHE73_10885 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FHE73_10900 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FHE73_10905 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FHE73_10915 ENOG4107RVG penicillin-binding protein FHE73_10920 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FHE73_10925 ENOG4105E9Q Acyl-transferase FHE73_10930 ENOG4108UT2 hemolysin iii FHE73_10940 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FHE73_10950 ENOG4108RCR degv family FHE73_10960 ENOG4108KF3 Electron transport protein SCO1 SenC FHE73_10965 ENOG4107Y70 Heat shock protein FHE73_10970 ENOG4105CAQ asparagine synthetase FHE73_10985 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FHE73_10990 ENOG4108MES Periplasmic binding protein FHE73_10995 ENOG4105F0I Aminotransferase FHE73_11025 ENOG4105D8X mechanosensitive ion channel FHE73_11030 ENOG4105BZU Histidine kinase FHE73_11035 ENOG4105WH1 Two component transcriptional regulator luxr family FHE73_11040 ENOG4106KNT transcriptional regulator FHE73_11045 ENOG4107ZY0 Phenazine biosynthesis-like protein FHE73_11065 ENOG4105CMG Carbohydrate kinase FHE73_11070 ENOG4105C6Z Gluconate FHE73_11080 ENOG4108YV3 Protein of unknown function (DUF2711) FHE73_11110 ENOG4108IJ8 ABC transporter FHE73_11115 ENOG4105E90 ABC transporter FHE73_11150 ENOG4105C37 (CBS) domain FHE73_11175 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FHE73_11190 ENOG4107S4Y M20 DapE family protein YgeY FHE73_11195 ENOG4108TSC N-acetyltransferase FHE73_11200 ENOG4108JUB Transcriptional regulator FHE73_11205 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FHE73_11250 ENOG410841Q phosphoesterase PA-phosphatase related protein FHE73_11260 ENOG4105SZ6 Thioredoxin FHE73_11265 ENOG4105KNA -acetyltransferase FHE73_11325 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FHE73_11380 ENOG4105BZ4 penicillin-binding protein FHE73_11390 ENOG4105CZM Major Facilitator FHE73_11395 ENOG4105W8X HesB YadR YfhF-family protein FHE73_11405 ENOG4105DXD 2-methylcitrate dehydratase FHE73_11410 ENOG4105CR4 methylisocitrate lyase FHE73_11415 ENOG4105C1G acyl-Coa dehydrogenase FHE73_11420 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FHE73_11430 ENOG4105N14 lysine exporter protein LysE YggA FHE73_11435 ENOG4105E39 Enoyl-CoA hydratase FHE73_11450 ENOG4107RFY SbcCD D subunit FHE73_11455 ENOG4105EYH Exonuclease FHE73_11460 ENOG4105VTR Integrase FHE73_11530 ENOG4105VTR Integrase FHE73_11655 ENOG4105FCD Major Facilitator FHE73_11660 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FHE73_11665 ENOG4105E4F Isochorismate synthase FHE73_11670 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FHE73_11675 ENOG4105WQI isochorismatase FHE73_11680 ENOG4105CEY Amp-dependent synthetase and ligase FHE73_11685 ENOG4105WQT MbtH domain protein FHE73_11690 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHE73_11705 ENOG4105K70 DNA-binding protein FHE73_11725 ENOG4105BZG amino acid carrier protein FHE73_11745 ENOG4105FE9 pseudouridine synthase FHE73_11750 ENOG4105C22 threonyL-tRNA synthetase FHE73_11755 ENOG4105C19 ABC transporter FHE73_11785 ENOG41081I9 integral membrane protein FHE73_11795 ENOG4108Y4K DNA-binding transcriptional activator FHE73_11825 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FHE73_11835 ENOG4105EYF MMPL domain protein FHE73_11890 ENOG4105C1Q protoporphyrinogen oxidase FHE73_11900 ENOG41068WN FHE73_11930 ENOG4107V2S Transcriptional regulator FHE73_11935 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FHE73_11960 ENOG4108RPX mosc domain containing protein FHE73_11975 ENOG4105BZ1 (ABC) transporter FHE73_11980 ENOG4105BZ1 (ABC) transporter FHE73_12000 ENOG4105VTR Integrase FHE73_12015 ENOG4108IMY Transcriptional regulator FHE73_12040 ENOG4106CVF DNA replication protein FHE73_12050 ENOG4105KRN Transcriptional regulator, abrb family FHE73_12165 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FHE73_12245 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FHE73_12265 ENOG4107TSN permease FHE73_12295 ENOG4108JCI Transcriptional regulator FHE73_12325 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FHE73_12330 ENOG4108KPJ rna polymerase sigma factor FHE73_12355 ENOG4105F32 YngK protein FHE73_12375 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) FHE73_12380 ENOG4105RD7 BadF BadG BcrA BcrD FHE73_12385 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FHE73_12390 ENOG4107STF Involved in phosphonate degradation (By similarity) FHE73_12395 ENOG4105C7B Threonine dehydratase FHE73_12400 ENOG4108INS Transcriptional regulator FHE73_12415 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FHE73_12420 ENOG4105C1J atp-dependent rna helicase FHE73_12430 ENOG4108RZE Tetr family transcriptional regulator FHE73_12450 ENOG41088CC tellurite resistance protein tehB FHE73_12460 ENOG4108I0C methyltransferase FHE73_12465 ENOG4107RA9 decarboxylase FHE73_12475 ENOG4105K56 Transcriptional regulator FHE73_12480 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FHE73_12505 ENOG4105CIN aminoacyl-histidine dipeptidase FHE73_12530 ENOG4105KRN Transcriptional regulator, abrb family FHE73_12540 ENOG4105EJ9 Membrane FHE73_12545 ENOG4105EQK -acetyltransferase FHE73_12585 ENOG4105W8Z 4'-phosphopantetheinyl transferase FHE73_12610 ENOG4105CSV Glutaminase FHE73_12630 ENOG4108Q8B Spore germination protein FHE73_12635 ENOG4108NHD germination protein FHE73_12645 ENOG4105II7 pyrroline-5-carboxylate reductase FHE73_12655 ENOG4105CUB amino acid FHE73_12660 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FHE73_12665 ENOG4105YWU small acid-soluble spore protein FHE73_12680 ENOG41075H3 AraC family transcriptional regulator FHE73_12705 ENOG4105BZU Histidine kinase FHE73_12715 ENOG4108B31 Spore germination protein FHE73_12775 ENOG4108IMY Transcriptional regulator FHE73_12780 ENOG4105BZC d-serine deaminase FHE73_12790 ENOG4107VMI polysaccharide deacetylase FHE73_12805 ENOG4107RVG penicillin-binding protein FHE73_12820 ENOG4107RF6 penicillin-binding protein FHE73_12825 ENOG4107RF6 penicillin-binding protein FHE73_12835 ENOG4105DIN metallophosphoesterase FHE73_12845 ENOG4105CJ1 ABC, transporter FHE73_12855 ENOG4107Z3H Transcriptional regulator, TetR family FHE73_12870 ENOG4105C1G acyl-Coa dehydrogenase FHE73_12875 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FHE73_12880 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FHE73_12885 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FHE73_12890 ENOG4105E39 Enoyl-CoA hydratase FHE73_12895 ENOG4107QX3 carboxylase FHE73_12900 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FHE73_12920 ENOG4105DBI uridine monophosphokinase FHE73_12940 ENOG4105DZ1 carboxypeptidase FHE73_12965 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FHE73_12985 ENOG41075H3 AraC family transcriptional regulator FHE73_13020 ENOG4107Y80 Major Facilitator superfamily FHE73_13030 ENOG4105KVH Transcriptional regulator FHE73_13035 ENOG41089UC methyltransferase, type 11 FHE73_13050 ENOG4105MDS 4-oxalocrotonate tautomerase FHE73_13055 ENOG4107V2S Transcriptional regulator FHE73_13080 ENOG4105SX7 Transporter FHE73_13105 ENOG4108V4B ThiJ pfpI FHE73_13120 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FHE73_13130 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FHE73_13200 ENOG4105D6E homoserine dehydrogenase FHE73_13210 ENOG4105CPF Cell wall formation (By similarity) FHE73_13215 ENOG4105ETU transcriptional activator (TenA FHE73_13245 ENOG4105VTR Integrase FHE73_13275 ENOG4105KRN Transcriptional regulator, abrb family FHE73_13390 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FHE73_13460 ENOG4105XSJ toxin secretion phage lysis holin FHE73_13545 ENOG410667J hydrolase FHE73_13550 ENOG4105BZU Histidine kinase FHE73_13555 ENOG4107RF6 penicillin-binding protein FHE73_13575 ENOG4108FPN Integrase FHE73_13620 ENOG4105VZ8 Transcriptional regulator FHE73_13640 ENOG4108BSC Methyltransferase FHE73_13645 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FHE73_13650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FHE73_13655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FHE73_13660 ENOG4105C3U ABC transporter FHE73_13665 ENOG4108JQ7 (ABC) transporter FHE73_13750 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding FHE73_13765 ENOG4105XRQ Xanthine dehydrogenase accessory factor FHE73_13795 ENOG4108R5S membrane FHE73_13805 ENOG4107RIQ Sulfate adenylate transferase FHE73_13810 ENOG4107S4M Sulfate adenylate transferase FHE73_13815 ENOG4108MEK Metal-binding protein YodA FHE73_13855 ENOG4108HGU Histidine kinase FHE73_13905 ENOG4105CB2 alcohol dehydrogenase FHE73_13910 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FHE73_13915 ENOG4105CJN penicillin-binding protein FHE73_13920 ENOG4108IG5 Transcriptional regulator FHE73_13925 ENOG4105CHR reductase FHE73_13965 ENOG4107Y80 Major Facilitator superfamily FHE73_13980 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FHE73_14005 ENOG4107Y9U Membrane FHE73_14025 ENOG4105EGD dinuclear metal center protein, YbgI family FHE73_14045 ENOG4105FCD Major Facilitator FHE73_14060 ENOG4105E09 nadh pyrophosphatase FHE73_14065 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FHE73_14085 ENOG4108XI2 Domain of unknown function (DUF1963) FHE73_14110 ENOG4108NRW Phospholipase, patatin family FHE73_14115 ENOG4105KWG Pfam:DUF1696 FHE73_14125 ENOG4108YYS metal-dependent hydrolase (By similarity) FHE73_14140 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FHE73_14150 ENOG4105PKS Excinuclease abc c subunit domain protein FHE73_14190 ENOG4107VFR oxidoreductase FHE73_14215 ENOG4105U0R haloacid dehalogenase-like hydrolase FHE73_14220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_14225 ENOG4105BZU Histidine kinase FHE73_14245 ENOG4107WD8 ABC transporter, permease FHE73_14260 ENOG4105DY8 decarboxylase FHE73_14275 ENOG4108IUM Glycogen debranching enzyme FHE73_14285 ENOG4105CGH 5'-nucleotidase FHE73_14300 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FHE73_14305 ENOG4105FDR Membrane FHE73_14310 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FHE73_14360 ENOG4105MSI germination protein ypeb FHE73_14395 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) FHE73_14400 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) FHE73_14405 ENOG4107Z3H Transcriptional regulator, TetR family FHE73_14440 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FHE73_14455 ENOG4105E98 transcriptional regulator DeoR family FHE73_14470 ENOG41062ES Transcriptional regulator FHE73_14495 ENOG4107QKR Dehydrogenase FHE73_14505 ENOG4107RUY (E1 component), alpha subunit FHE73_14515 ENOG4105E1F short-chain dehydrogenase reductase FHE73_14545 ENOG4107SQ8 Glycine betaine FHE73_14550 ENOG4108IJ7 Glycine betaine FHE73_14575 ENOG4105E66 phosphoriboisomerase A FHE73_14580 ENOG41082BV acetyltransferase FHE73_14585 ENOG4108M1A Chitin-binding protein FHE73_14610 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FHE73_14615 ENOG4105MSB protein, conserved in bacteria FHE73_14640 ENOG4108Z7F N-acetyltransferase FHE73_14665 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FHE73_14670 ENOG4105EEM helicase FHE73_14685 ENOG4105C9U ATP-dependent DNA helicase RecQ FHE73_14730 ENOG4108M1A Chitin-binding protein FHE73_14745 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FHE73_14755 ENOG4105BZG amino acid carrier protein FHE73_14760 ENOG4105C26 Dehydrogenase FHE73_14765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FHE73_14770 ENOG4105CTU Proline racemase FHE73_14775 ENOG4105CTU Proline racemase FHE73_14780 ENOG41080HI glycine oxidase FHE73_14790 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FHE73_14825 ENOG4105DCI Phosphohydrolase FHE73_14830 ENOG4107T5V SNARE associated Golgi FHE73_14840 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FHE73_14855 ENOG4105DTQ mandelate racemase muconate lactonizing FHE73_14870 ENOG4107SET aldo keto reductase FHE73_14905 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FHE73_14910 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FHE73_14915 ENOG4105BZU Histidine kinase FHE73_14920 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_14935 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FHE73_14955 ENOG4105EPR degv family FHE73_15015 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FHE73_15020 ENOG4106K7D Major facilitator family transporter FHE73_15040 ENOG4107BMA Transglycosylase associated protein FHE73_15055 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) FHE73_15090 ENOG4105CHM Aminotransferase FHE73_15145 ENOG4105C02 permease FHE73_15160 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FHE73_15165 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FHE73_15170 ENOG4105D7T ABC transporter FHE73_15195 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FHE73_15240 ENOG4107VC0 DNA alkylation repair enzyme FHE73_15245 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FHE73_15255 ENOG4107VMI polysaccharide deacetylase FHE73_15260 ENOG4108ZCF integral membrane protein FHE73_15265 ENOG4105E0M Sulfatase FHE73_15270 ENOG4105C5H ABC transporter FHE73_15275 ENOG4105EYF MMPL domain protein FHE73_15280 ENOG41082JN Transcriptional regulator FHE73_15300 ENOG4105CIH Imidazole acetol-phosphate transaminase FHE73_15305 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FHE73_15310 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FHE73_15360 ENOG41069ER domain protein FHE73_15370 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FHE73_15385 ENOG4105EMN RNA polymerase sigma factor FHE73_15410 ENOG4105D4B ABC, transporter FHE73_15415 ENOG4105F5R ABC transporter FHE73_15420 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FHE73_15430 ENOG4105DKT Transcriptional regulator FHE73_15435 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FHE73_15445 ENOG41061GT Aldolase FHE73_15465 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FHE73_15500 ENOG4105II7 pyrroline-5-carboxylate reductase FHE73_15510 ENOG4107258 Transcriptional regulator FHE73_15530 ENOG4105ECK Fatty Acid Desaturase FHE73_15540 ENOG4107RBI VanW family FHE73_15545 ENOG4105G6Z alkaline phosphatase FHE73_15555 ENOG4105VMP Transcriptional regulator FHE73_15575 ENOG41068WN FHE73_15605 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FHE73_15630 ENOG4105CKK Glycosyl transferase, family 2 FHE73_15650 ENOG4105CKK Glycosyl transferase, family 2 FHE73_15660 ENOG4105C8Y Acetylornithine aminotransferase FHE73_15700 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FHE73_15725 ENOG4108IBT Inherit from COG: transposase FHE73_15745 ENOG4108TVJ Nitroreductase FHE73_15750 ENOG4105FS7 Transcriptional regulator FHE73_15775 ENOG4105WEC Molybdate metabolism regulator FHE73_15800 ENOG4108XET gCN5-related N-acetyltransferase FHE73_15815 ENOG4108PCN EamA-like transporter family FHE73_15865 ENOG410635A Membrane FHE73_15875 ENOG4108IQI permease FHE73_15890 ENOG4105F1N DNA alkylation repair FHE73_15900 ENOG4105BZU Histidine kinase FHE73_15905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_15915 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FHE73_15950 ENOG4107RF6 penicillin-binding protein FHE73_15955 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FHE73_15975 ENOG4105E7W lamb ycsf family protein FHE73_15985 ENOG4105P4J Allophanate hydrolase, subunit 1 FHE73_15990 ENOG4107258 Transcriptional regulator FHE73_16000 ENOG4106N3A copper homeostasis protein cutc FHE73_16005 ENOG4108ZHR arsR family transcriptional regulator FHE73_16015 ENOG4105FDT acyl-CoA dehydrogenase FHE73_16030 ENOG4105DWD nucleoside recognition domain protein FHE73_16065 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FHE73_16130 ENOG4105E2A Dehydrogenase FHE73_16140 ENOG4105CN5 Metallo-Beta-Lactamase FHE73_16165 ENOG4105CGH 5'-nucleotidase FHE73_16175 ENOG4105CHJ isochorismatase hydrolase FHE73_16280 ENOG4105F6J Alpha beta hydrolase fold FHE73_16295 ENOG4108606 TspO/MBR family FHE73_16300 ENOG4105CVP deoxyribo-dipyrimidine photolyase FHE73_16335 ENOG4108TWJ NADH dehydrogenase subunit 5 FHE73_16340 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FHE73_16355 ENOG4105E1K spore germination protein FHE73_16370 ENOG4108U7W acetyltransferase FHE73_16375 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FHE73_16380 ENOG4105DSE periplasmic solute binding protein FHE73_16385 ENOG4105CC5 ABC transporter FHE73_16390 ENOG4105DIK (ABC) transporter FHE73_16415 ENOG4105D6J arsenicaL-resistance protein FHE73_16420 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FHE73_16425 ENOG41085FC arsR family transcriptional regulator FHE73_16475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_16480 ENOG41062D9 Histidine kinase FHE73_16510 ENOG4105WH1 Two component transcriptional regulator luxr family FHE73_16540 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FHE73_16545 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHE73_16560 ENOG4105K6H D-cysteine desulfhydrase FHE73_16575 ENOG4105E0Y RtcB Protein FHE73_16585 ENOG4105JQZ Methyltransferase FHE73_16600 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FHE73_16605 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FHE73_16630 ENOG4105BZU Histidine kinase FHE73_16640 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FHE73_16665 ENOG4108JQ1 Dehydrogenase FHE73_16685 ENOG41082W1 Cupin 2, conserved barrel domain protein FHE73_16695 ENOG410874W AraC family transcriptional regulator FHE73_16715 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FHE73_16725 ENOG4108IG5 Transcriptional regulator FHE73_16810 ENOG4108VXD carboxy-peptidase FHE73_16815 ENOG4105PNM synthesis protein FHE73_16825 ENOG4108ISG Major Facilitator FHE73_16840 ENOG4107MII Sugar-specific transcriptional regulator TrmB FHE73_16845 ENOG4105CZM Major Facilitator FHE73_16855 ENOG4105CRW Short chain fatty acid transporter FHE73_16870 ENOG4105DYS nad(p)h dehydrogenase (quinone) FHE73_16930 ENOG4108K8S endonuclease I FHE73_16935 ENOG4108Z66 YbaK ebsC protein FHE73_16955 ENOG4105KVH Transcriptional regulator FHE73_16960 ENOG4108RCM Nitroreductase FHE73_16990 ENOG4108PSK reductase FHE73_17000 ENOG4105CJ1 ABC, transporter FHE73_17060 ENOG4105C31 Tryptophanyl-tRNA synthetase FHE73_17120 ENOG4105C37 (CBS) domain FHE73_17135 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FHE73_17140 ENOG4105FAW cDP-glucose 4,6-dehydratase FHE73_17165 ENOG4105DDN Pentapeptide repeat-containing protein FHE73_17175 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FHE73_17180 ENOG4105CMG Carbohydrate kinase FHE73_17185 ENOG4105C6Z Gluconate FHE73_17190 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FHE73_17200 ENOG4105CV1 Transketolase (EC 2.2.1.1) FHE73_17205 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FHE73_17230 ENOG4108UX3 '-nucleotidase FHE73_17235 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FHE73_17240 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) FHE73_17245 ENOG4105KVH Transcriptional regulator FHE73_17255 ENOG41090KN UPF0303 protein FHE73_17275 ENOG4105C44 Serine transporter FHE73_17305 ENOG4108TZY GntR Family Transcriptional Regulator FHE73_17310 ENOG4105D9R oxidoreductase FHE73_17350 ENOG4105JAB phenazine biosynthesis protein, phzf family FHE73_17360 ENOG4108RU0 short-chain dehydrogenase reductase FHE73_17375 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FHE73_17380 ENOG4105KVH Transcriptional regulator FHE73_17385 ENOG4107SCK Monooxygenase FHE73_17405 ENOG4108ZJ4 polysaccharide deacetylase FHE73_17470 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FHE73_17505 ENOG4105H3G oxidoreductase FHE73_17540 ENOG4105CIS alcohol dehydrogenase FHE73_17580 ENOG4108TN2 lmbE family FHE73_17590 ENOG4107R3E Citrate transporter FHE73_17605 ENOG4108MES Periplasmic binding protein FHE73_17610 ENOG4105EHG Permease protein FHE73_17615 ENOG4105DQ5 transport system permease protein FHE73_17620 ENOG4105NX3 Membrane FHE73_17640 ENOG4107CUJ Protein of unknown function (DUF2690) FHE73_17650 ENOG4107V2S Transcriptional regulator FHE73_17670 ENOG4105C98 muts2 protein FHE73_17680 ENOG4105E5K Alpha-amylase FHE73_17685 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FHE73_17690 ENOG4105DPN Oligoendopeptidase f FHE73_17695 ENOG4108A04 Beta-lactamase FHE73_17720 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FHE73_17730 ENOG41082BM Transcriptional regulator, arsr family FHE73_17735 ENOG4105CIS alcohol dehydrogenase FHE73_17770 ENOG4105C09 Bile acid FHE73_17775 ENOG4105CQB FAD linked oxidase domain protein FHE73_17835 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHE73_17905 ENOG4105BZU Histidine kinase FHE73_17910 ENOG4105C5H ABC transporter FHE73_17920 ENOG4107DUR UPF0457 protein FHE73_17940 ENOG4105BZU Histidine kinase FHE73_17950 ENOG4105KT7 mgtC SapB transporter FHE73_17960 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FHE73_17965 ENOG41073R8 VanW family FHE73_17975 ENOG4108R1P FHE73_17990 ENOG4105VEQ Cold shock protein FHE73_18010 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FHE73_18030 ENOG410904N short-chain dehydrogenase reductase FHE73_18040 ENOG4106IQC argininosuccinate lyase FHE73_18055 ENOG4108IA2 Sodium pantothenate symporter FHE73_18065 ENOG4105C26 Dehydrogenase FHE73_18070 ENOG4105CHR reductase FHE73_18080 ENOG4105EWU Squalene--hopene cyclase FHE73_18090 ENOG4105FR1 rard protein FHE73_18095 ENOG410696E Membrane FHE73_18110 ENOG4105D1F ATP-binding protein FHE73_18120 ENOG4108ZAF Molybdopterin FHE73_18125 ENOG4105CVM Molybdenum cofactor synthesis domain protein FHE73_18130 ENOG4105D06 uba thif-type nad fad binding protein FHE73_18135 ENOG4105TMB Formate nitrite transporter FHE73_18145 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FHE73_18150 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FHE73_18160 ENOG4108JB9 formate dehydrogenase FHE73_18165 ENOG4105E1K spore germination protein FHE73_18230 ENOG4107QJT sodium dicarboxylate symporter FHE73_18235 ENOG4108KGH TRANSCRIPTIONal FHE73_18245 ENOG4105EMN RNA polymerase sigma factor FHE73_18255 ENOG4105CIG ABC transporter FHE73_18265 ENOG4105D9R oxidoreductase FHE73_18275 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FHE73_18280 ENOG4105K4P CoA-binding domain protein FHE73_18285 ENOG4105C0H protease FHE73_18290 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_18300 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FHE73_18305 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FHE73_18310 ENOG4105W8X HesB YadR YfhF-family protein FHE73_18340 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FHE73_18345 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FHE73_18360 ENOG4105BZ1 (ABC) transporter FHE73_18365 ENOG4108I0Z Aconitate hydratase FHE73_18395 ENOG4105E5W Transporter FHE73_18405 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FHE73_18425 ENOG4107F3J Amp-dependent synthetase and ligase FHE73_18430 ENOG4107ZYJ bioY protein FHE73_18435 ENOG4105CEY Amp-dependent synthetase and ligase FHE73_18450 ENOG4108IMY Transcriptional regulator FHE73_18495 ENOG4107AYK membrAne FHE73_18510 ENOG4105BZU Histidine kinase FHE73_18515 ENOG4105FBA Phospholipase Carboxylesterase FHE73_18520 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FHE73_18525 ENOG4105CK7 Sodium proline symporter FHE73_18535 ENOG4105CBC glutamate synthase FHE73_18540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FHE73_18545 ENOG4108VJ1 Transcriptional regulator (CarD family FHE73_18550 ENOG4108903 Formimidoylglutamase FHE73_18560 ENOG4105CGP Urocanate hydratase FHE73_18575 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FHE73_18610 ENOG4107QIV Cytochrome c biogenesis protein FHE73_18625 ENOG4105CH2 amidohydrolase FHE73_18640 ENOG4105CJ1 ABC, transporter FHE73_18655 ENOG4107RSM transcriptional regulator FHE73_18660 ENOG4105VAW lrga family FHE73_18665 ENOG41067MG lrgb family FHE73_18670 ENOG4107VIJ nudix hydrolase FHE73_18705 ENOG4105BZ1 (ABC) transporter FHE73_18710 ENOG4105BZ1 (ABC) transporter FHE73_18750 ENOG4105CGH 5'-nucleotidase FHE73_18760 ENOG4108SVB resolvase FHE73_18780 ENOG4105K7K Transcriptional regulator FHE73_18790 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FHE73_18795 ENOG4105DR5 peptidase FHE73_18800 ENOG41065S2 pneumococcal vaccine antigen FHE73_18830 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FHE73_18835 ENOG4105C5F glutamine synthetase FHE73_18840 ENOG4105KV4 Transcriptional regulator FHE73_18845 ENOG4105CXI aluminum resistance protein FHE73_18850 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FHE73_18855 ENOG4105EN6 Membrane FHE73_18860 ENOG4106F1P AAA ATPase, central domain protein FHE73_18890 ENOG41069ER domain protein FHE73_18895 ENOG4105DM4 PTS System FHE73_18900 ENOG4105DE4 1-phosphofructokinase FHE73_18905 ENOG4105E98 transcriptional regulator DeoR family FHE73_18910 ENOG4107QW4 alcohol dehydrogenase FHE73_18915 ENOG4108SJC Membrane FHE73_18925 ENOG4105C85 amino acid FHE73_18950 ENOG4105TMB Formate nitrite transporter FHE73_18955 ENOG4105K70 DNA-binding protein FHE73_18965 ENOG4105C59 p-type ATPase FHE73_18970 ENOG410681U heavy metal transport detoxification protein FHE73_18975 ENOG4105VPX protein, conserved in bacteria FHE73_18985 ENOG4105NIV Esterase FHE73_18990 ENOG4105E0A ABC, transporter FHE73_19010 ENOG4105CGK Exodeoxyribonuclease III FHE73_19020 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FHE73_19025 ENOG4105D03 DNA-3-methyladenine glycosylase II FHE73_19055 ENOG4105BZU Histidine kinase FHE73_19075 ENOG4105C5E polysaccharide biosynthesis protein FHE73_19110 ENOG4105C8Q Methyl-accepting chemotaxis FHE73_19125 ENOG4105F0V Cell wall hydrolase FHE73_19140 ENOG4105E0M Sulfatase FHE73_19145 ENOG410890F Dynamin family FHE73_19185 ENOG4105DQU oxidoreductase, subunit beta FHE73_19190 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FHE73_19195 ENOG4108IGT Dipeptidase FHE73_19200 ENOG4105MCT stage V sporulation protein S FHE73_19205 ENOG4105D48 metallophosphoesterase FHE73_19225 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FHE73_19240 ENOG4105XZV Protein of unknown function (DUF3243) FHE73_19245 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FHE73_19265 ENOG4105UIB (ABC) transporter FHE73_19270 ENOG4108JQ9 ABC transporter FHE73_19275 ENOG4105DIH basic membrane FHE73_19280 ENOG4105FDP GntR family transcriptional regulator FHE73_19295 ENOG4105CNU cell division protein FtsK FHE73_19305 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FHE73_19315 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FHE73_19325 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FHE73_19330 ENOG4108S0H Dipicolinic acid synthetase, b subunit FHE73_19335 ENOG4108IBT Inherit from COG: transposase FHE73_19350 ENOG4105XSJ toxin secretion phage lysis holin FHE73_19520 ENOG4105CDU Replicative dna helicase FHE73_19555 ENOG4108IMY Transcriptional regulator FHE73_19585 ENOG4105E35 Dipicolinate synthase subunit A FHE73_19595 ENOG4105C1V Peptidase, M16 FHE73_19615 ENOG4105DTN riboflavin biosynthesis protein ribF FHE73_19630 ENOG4105W7A Protein of unknown function (DUF503) FHE73_19640 ENOG4105VHM ribosomal protein FHE73_19645 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FHE73_19650 ENOG4105CHV Transcription elongation factor NusA FHE73_19660 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FHE73_19670 ENOG4105DZP Membrane-associated zinc metalloprotease FHE73_19675 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FHE73_19680 ENOG4105KNE Phosphatidate cytidylyltransferase FHE73_19685 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FHE73_19695 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FHE73_19725 ENOG4108HE4 integrase family FHE73_19735 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FHE73_19740 ENOG4105C79 DNA protecting protein DprA FHE73_19745 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FHE73_19760 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FHE73_19785 ENOG4105VB6 UPF0109 protein FHE73_19805 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FHE73_19810 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FHE73_19825 ENOG4105CHR reductase FHE73_19830 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FHE73_19845 ENOG4105CB5 ATP-dependent DNA helicase recG FHE73_19850 ENOG4105DP4 dak2 domain fusion protein ylov FHE73_19855 ENOG4108ZAA Alkaline-shock protein FHE73_19870 ENOG4105FJ0 thiamine FHE73_19875 ENOG4105DJV ribulose-phosphate 3-epimerase FHE73_19880 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FHE73_19885 ENOG4105D9P serine threonine protein kinase FHE73_19890 ENOG4108ZF3 Phosphatase FHE73_19900 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FHE73_19915 ENOG4105C25 Primosomal protein n' FHE73_19920 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FHE73_19940 ENOG4105DSJ YicC domain protein FHE73_19950 ENOG4105F23 Fibronectin-binding protein FHE73_19960 ENOG4105DC7 peptidase M24 FHE73_20005 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FHE73_20010 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FHE73_20020 ENOG4105CD3 dihydroorotase FHE73_20040 ENOG4105C34 Pseudouridine synthase FHE73_20055 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FHE73_20065 ENOG4105DBK s4 domain protein FHE73_20070 ENOG41067XK integral membrane protein FHE73_20080 ENOG4105DFA alanine racemase domain protein FHE73_20085 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FHE73_20090 ENOG4105WR5 sporulation protein, YlmC YmxH family FHE73_20100 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHE73_20110 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FHE73_20115 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FHE73_20125 ENOG4105D4A Cell wall formation (By similarity) FHE73_20130 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FHE73_20135 ENOG4105CNI cell division protein FtsW FHE73_20150 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FHE73_20155 ENOG4105CJN penicillin-binding protein FHE73_20160 ENOG4105CJN penicillin-binding protein FHE73_20175 ENOG41074B2 UPF0747 protein FHE73_20200 ENOG4105KNH Nucleic acid-binding protein FHE73_20470 ENOG4108IMY Transcriptional regulator FHE73_20490 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FHE73_20500 ENOG41063PX domain protein FHE73_20505 ENOG4105D78 K07001 NTE family protein FHE73_20510 ENOG4105H20 Sporulation integral membrane protein YlbJ FHE73_20520 ENOG4106H78 methyltransferase FHE73_20540 ENOG4107TB6 phosphoglycerate mutase FHE73_20555 ENOG4106UY4 Inherit from COG: Scp-like extracellular FHE73_20605 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FHE73_20615 ENOG4105CNI cell division protein FtsW FHE73_20630 ENOG4108IAB Phoh family FHE73_20650 ENOG4105QA2 FHE73_20655 ENOG4105CI3 gtp-binding protein typa FHE73_20665 ENOG4105ECY inositol monophosphatase FHE73_20685 ENOG4105CXN decarboxylase FHE73_20735 ENOG4105CPP Dehydrogenase, E1 component FHE73_20750 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FHE73_20755 ENOG4108X4Q Hydrolase FHE73_20770 ENOG4105CN5 Metallo-Beta-Lactamase FHE73_20775 ENOG4107ZYR domain protein FHE73_20810 ENOG4108XRC Protein of unknown function (DUF458) FHE73_20815 ENOG4107IN1 Protein of unknown function (DUF1797) FHE73_20830 ENOG4105EPM Diguanylate phosphodiesterase FHE73_20835 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FHE73_20850 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FHE73_20860 ENOG4105UIN FHE73_20895 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FHE73_20915 ENOG4108HGU Histidine kinase FHE73_20925 ENOG4105CHM Aminotransferase FHE73_20930 ENOG4105FKQ transcriptional regulator FHE73_20935 ENOG4105EG2 ABC transporter, permease FHE73_20945 ENOG4107FKK extracellular solute-binding protein family 1 FHE73_20955 ENOG4105CG3 alpha amylase, catalytic region FHE73_21000 ENOG4105CHU acetyl-coa acetyltransferase FHE73_21035 ENOG4105K7K Transcriptional regulator FHE73_21040 ENOG4105DTD Dehydrogenase FHE73_21060 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FHE73_21100 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FHE73_21110 ENOG4105BZU Histidine kinase FHE73_21130 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FHE73_21145 ENOG4105CID antiterminator FHE73_21155 ENOG4105FDP GntR family transcriptional regulator FHE73_21165 ENOG4105CE4 GlcNAc 6-P deacetylase FHE73_21205 ENOG4107ZE5 PPIases accelerate the folding of proteins FHE73_21210 ENOG4105PTM secreted protein FHE73_21215 ENOG4105J7I hydrolase FHE73_21235 ENOG4105CZ3 stage V sporulation protein ad FHE73_21240 ENOG41090VF Stage v sporulation protein ac FHE73_21260 ENOG4105C8J )-transporter FHE73_21265 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHE73_21275 ENOG41082AN stage II sporulation protein FHE73_21280 ENOG4105DZ1 carboxypeptidase FHE73_21290 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FHE73_21295 ENOG4105DVE abc transporter atp-binding protein FHE73_21325 ENOG4105D7N magnesium and cobalt transport protein CorA FHE73_21350 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHE73_21360 ENOG4105I3K Ferric uptake regulator, Fur family FHE73_21365 ENOG4105MZ9 stage II sporulation protein m FHE73_21385 ENOG4105CPC Aldo Keto reductase FHE73_21395 ENOG4105RHY Pfam:UPF0157 FHE73_21415 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FHE73_21425 ENOG4105ETE Transcriptional regulator (LacI family FHE73_21430 ENOG4108YM7 Gcn5-related n-acetyltransferase FHE73_21455 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FHE73_21460 ENOG4108R6K riboflavin synthase, subunit alpha FHE73_21485 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FHE73_21490 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FHE73_21505 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FHE73_21515 ENOG4105DFD Na H antiporter FHE73_21520 ENOG4105CGH 5'-nucleotidase FHE73_21545 ENOG4105DBV ornithine carbamoyltransferase FHE73_21560 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FHE73_21575 ENOG4108IXY short-chain dehydrogenase reductase FHE73_21580 ENOG41069FQ Metallo-beta-lactamase superfamily FHE73_21585 ENOG4105II7 pyrroline-5-carboxylate reductase FHE73_21590 ENOG4105EJQ L-serine dehydratase FHE73_21605 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FHE73_21630 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FHE73_21635 ENOG4105D9U N-acetyltransferase FHE73_21645 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FHE73_21650 ENOG4108QEG Membrane FHE73_21655 ENOG4105CDA abc transporter atp-binding protein FHE73_21660 ENOG4105E5Q amino acid AbC transporter FHE73_21665 ENOG4108HW3 (ABC) transporter FHE73_21675 ENOG4105G7B Protein of unknown function (DUF2992) FHE73_21685 ENOG4108QY0 Membrane FHE73_21695 ENOG4105C7S Dehydrogenase FHE73_21700 ENOG4105CPP Dehydrogenase, E1 component FHE73_21720 ENOG4107RDP Dehydrogenase FHE73_21735 ENOG4108JUB Transcriptional regulator FHE73_21745 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FHE73_21760 ENOG4107QQR Sporulation FHE73_21770 ENOG4105S1Z Stage IV sporulation protein B FHE73_21775 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FHE73_21785 ENOG4105DX0 Hemolysin A FHE73_21795 ENOG4105CTB Polyprenyl synthetase FHE73_21810 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FHE73_21820 ENOG4108ZSR alkaline shock protein FHE73_21825 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FHE73_21850 ENOG410644B Stage III sporulation protein af FHE73_21860 ENOG4105KQ4 Stage iii sporulation protein ad FHE73_21865 ENOG4108CQH stage III sporulation protein AC FHE73_21870 ENOG4105KR5 Stage iii sporulation protein FHE73_21875 ENOG4105CD2 stage iii sporulation protein aa FHE73_21900 ENOG4105DC7 peptidase M24 FHE73_21915 ENOG4105CBJ Metal-dependent enzyme FHE73_21925 ENOG4107YBY Hydrolase FHE73_21955 ENOG41082GG biotin lipoate A B protein ligase FHE73_21960 ENOG4105WZW rhodanese family FHE73_21985 ENOG41080TC multidrug resistance protein FHE73_22020 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FHE73_22055 ENOG4105C0D helicase FHE73_22140 ENOG4107R6U sodium dicarboxylate symporter FHE73_22175 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FHE73_22180 ENOG4105C3R Methionine synthase FHE73_22190 ENOG4105C28 cystathionine FHE73_22195 ENOG4105C28 cystathionine FHE73_22215 ENOG4105C5X domain protein FHE73_22225 ENOG4105DKQ ROK family FHE73_22235 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FHE73_22250 ENOG4108UTW Plays a role in the regulation of phosphate uptake FHE73_22255 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FHE73_22260 ENOG4105C8U phosphate abc transporter FHE73_22265 ENOG4105C8U phosphate abc transporter FHE73_22270 ENOG4105EXS phosphate abc transporter FHE73_22275 ENOG4107RF6 penicillin-binding protein FHE73_22285 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FHE73_22310 ENOG4105N80 Ferric uptake regulator, Fur family FHE73_22320 ENOG4105FDK ABC transporter FHE73_22325 ENOG4108JYZ YitT family FHE73_22330 ENOG41069ZM Protein of unknown function (DUF2624) FHE73_22355 ENOG4105EGD dinuclear metal center protein, YbgI family FHE73_22370 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHE73_22375 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FHE73_22400 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FHE73_22405 ENOG4105KG3 cytidine deaminase FHE73_22410 ENOG4107YR5 Diacylglycerol kinase FHE73_22420 ENOG4105CTJ Metal Dependent Phosphohydrolase FHE73_22425 ENOG4105C9A Phoh family FHE73_22435 ENOG41068P3 sporulation protein YqfC FHE73_22445 ENOG4105KTH gatB Yqey FHE73_22455 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FHE73_22460 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FHE73_22480 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FHE73_22490 ENOG4105CSA Coproporphyrinogen iii oxidase FHE73_22495 ENOG4105KVH Transcriptional regulator FHE73_22520 ENOG4105TQK DNA polymerase iii, delta' subunit FHE73_22535 ENOG4108UK2 deaminase FHE73_22540 ENOG4105KQC Competence protein FHE73_22550 ENOG4105DXX methyltransferase FHE73_22560 ENOG4108WF2 Metal Dependent Phosphohydrolase FHE73_22570 ENOG410812S Rna-binding protein FHE73_22580 ENOG4105CQW ribosome biogenesis GTPase YqeH FHE73_22585 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FHE73_22600 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHE73_22620 ENOG4108TVJ Nitroreductase FHE73_22635 ENOG4105G6Z alkaline phosphatase FHE73_22640 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FHE73_22645 ENOG4108MUZ hydrolase FHE73_22680 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FHE73_22685 ENOG4105MIR Phenylalanine 4-monooxygenase FHE73_22695 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FHE73_22735 ENOG4105S6R Iron-hydroxamate transporter permease subunit FHE73_22740 ENOG4108V5C ABC transporter FHE73_22755 ENOG4108EKI Dehydrogenase FHE73_22760 ENOG4105C28 cystathionine FHE73_22790 ENOG4107XRG penicillin-binding protein FHE73_22800 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FHE73_22810 ENOG4105CFP Peptidase U32 FHE73_22815 ENOG4105XYU peptidase (U32 family) FHE73_22820 ENOG4108VQJ O-methyltransferase FHE73_22825 ENOG4105HHA aminodeoxychorismate lyase FHE73_22855 ENOG4105C02 permease FHE73_22870 ENOG41060CR FHE73_22875 ENOG4105C7H Helicase, RecD TraA family FHE73_22885 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FHE73_22890 ENOG4105C3J Cysteine desulfurase FHE73_22900 ENOG4105D1H recombination factor protein RarA FHE73_22905 ENOG4108VCI transcription factor, rsfa family FHE73_22915 ENOG4105CUZ uba thif-type nad fad binding protein FHE73_22930 ENOG4105CUT histidyl-tRNA synthetase FHE73_22940 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FHE73_22945 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FHE73_22955 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FHE73_22960 ENOG41076HS cation diffusion facilitator family transporter FHE73_22965 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FHE73_22975 ENOG4105CKP Polysaccharide Biosynthesis Protein FHE73_22980 ENOG4108QG2 Membrane FHE73_22990 ENOG4105VIE preprotein translocase, subunit YajC FHE73_23005 ENOG41061AI Protein of unknown function (DUF2905) FHE73_23020 ENOG4108HUF Transporter FHE73_23050 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FHE73_23055 ENOG4108IYU L-aspartate oxidase FHE73_23070 ENOG4108RPX mosc domain containing protein FHE73_23080 ENOG4105CQC Prephenate dehydratase FHE73_23100 ENOG4105EWM Histidine kinase FHE73_23110 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FHE73_23130 ENOG4105C03 ribonuclease FHE73_23145 ENOG4107QMS site-determining protein FHE73_23160 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FHE73_23165 ENOG4105DFF Rod shape-determining protein mreb FHE73_23185 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FHE73_23190 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FHE73_23200 ENOG41068KH stage VI sporulation protein D FHE73_23210 ENOG4105D52 delta-aminolevulinic acid dehydratase FHE73_23235 ENOG4105K56 Transcriptional regulator FHE73_23255 ENOG4108IUQ atp-dependent protease FHE73_23285 ENOG4108QCI YvbH-like oligomerisation region FHE73_23335 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHE73_23350 ENOG4105M59 Phosphodiesterase, mj0936 family FHE73_23365 ENOG4108XJQ germination protein FHE73_23375 ENOG4108PCX Major Facilitator FHE73_23385 ENOG4105KBX Transcriptional regulator, TetR family FHE73_23400 ENOG4105PFC Transcriptional regulator FHE73_23410 ENOG4105DZC cytosine deaminase FHE73_23415 ENOG41067S9 phage shock protein C, PspC FHE73_23420 ENOG4108JCI Transcriptional regulator FHE73_23430 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FHE73_23435 ENOG4108Z40 Transcriptional regulator FHE73_23440 ENOG4105RHA ABC transporter, permease FHE73_23445 ENOG4108IUX (ABC) transporter FHE73_23450 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FHE73_23455 ENOG4105ER2 Ompa motb domain protein FHE73_23460 ENOG4105E14 MotA TolQ exbB proton channel FHE73_23465 ENOG4108VXD carboxy-peptidase FHE73_23475 ENOG4105E33 succinate dehydrogenase FHE73_23485 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FHE73_23495 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FHE73_23500 ENOG4105K63 Thioredoxin FHE73_23505 ENOG4105C10 Electron transfer flavoprotein FHE73_23510 ENOG4105BZJ Electron transfer flavoprotein FHE73_23515 ENOG41060WC Enoyl-CoA hydratase FHE73_23520 ENOG4107Z3H Transcriptional regulator, TetR family FHE73_23525 ENOG4105CEY Amp-dependent synthetase and ligase FHE73_23535 ENOG4105J76 Periplasmic binding protein FHE73_23540 ENOG4105S6R Iron-hydroxamate transporter permease subunit FHE73_23580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHE73_23590 ENOG4105DR4 Methyltransferase FHE73_23605 ENOG4105KFN sortase, SrtB family FHE73_23610 ENOG4105E0A ABC, transporter FHE73_23625 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FHE73_23635 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FHE73_23645 ENOG4105FE9 pseudouridine synthase FHE73_23655 ENOG4105DCG PHP domain protein FHE73_23670 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FHE73_23690 ENOG4105C5S asparaginyl-tRNA synthetase FHE73_23695 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FHE73_23705 ENOG4108RWN rrna methyltransferase FHE73_23735 ENOG4105C0R drug resistance transporter emrb qaca subfamily FHE73_23740 ENOG4105CW7 secretion protein, HlyD family FHE73_23745 ENOG4108JGH Tetr family transcriptional regulator FHE73_23750 ENOG4105CN9 Peptidase m42 family protein FHE73_23770 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FHE73_23775 ENOG4105C22 threonyL-tRNA synthetase FHE73_23780 ENOG4108TDW sporulation protein YtxC FHE73_23805 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FHE73_23810 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FHE73_23815 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FHE73_23825 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FHE73_23830 ENOG4105C2M dna polymerase I FHE73_23835 ENOG4105BZU Histidine kinase FHE73_23840 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHE73_23860 ENOG4108HMX isocitrate dehydrogenase (NADP) FHE73_23865 ENOG4105BZN citrate synthase FHE73_23880 ENOG4108REF Sporulation integral membrane protein ytvi FHE73_23885 ENOG4105FS0 cytoplasmic membrane protein FHE73_23910 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FHE73_23915 ENOG4105C6K Malic enzyme FHE73_23920 ENOG4105C0B DNA polymerase III (alpha subunit) FHE73_23925 ENOG4105VV2 FHE73_23935 ENOG4105SFS phosphoesterase RecJ domain protein FHE73_23960 ENOG4105E8R UPF0173 metal-dependent hydrolase FHE73_23965 ENOG4105DC7 peptidase M24 FHE73_24010 ENOG41082W1 Cupin 2, conserved barrel domain protein FHE73_24030 ENOG4107YZX Universal stress protein FHE73_24075 ENOG4108JYZ YitT family FHE73_24095 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FHE73_24105 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FHE73_24110 ENOG4105KBJ sporulation protein ytfj FHE73_24135 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FHE73_24160 ENOG4105RQF LysR family Transcriptional regulator FHE73_24170 ENOG4105U5Y Transcriptional regulator FHE73_24180 ENOG4105C28 cystathionine FHE73_24210 ENOG4108UW5 maltose o-acetyltransferase FHE73_24225 ENOG4105F1V Acetoin utilization protein FHE73_24230 ENOG4105W87 Cbs domain FHE73_24235 ENOG4105DGU Histone deacetylase FHE73_24240 ENOG4106HB6 Alpha beta hydrolase FHE73_24250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FHE73_24260 ENOG4107SNB ankyrin repeat protein YahD FHE73_24265 ENOG4105EP9 oxidoreductase FHE73_24290 ENOG4105ETE Transcriptional regulator (LacI family FHE73_24295 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FHE73_24315 ENOG4105C88 aminopeptidase FHE73_24350 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FHE73_24360 ENOG4108VDD TRNA binding domain protein FHE73_24390 ENOG4105C8F Beta-lactamase domain protein FHE73_24405 ENOG4108V15 phosphotransferase enzyme family FHE73_24410 ENOG4108IUM Glycogen debranching enzyme FHE73_24420 ENOG4107QSE Dipeptidase FHE73_24425 ENOG4105YW5 deoR family transcriptional regulator FHE73_24440 ENOG4105CBX hi0933 family FHE73_24480 ENOG4108VJ1 Transcriptional regulator (CarD family FHE73_24485 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FHE73_24490 ENOG4105CSC Glucose uptake protein FHE73_24505 ENOG4108ZAF Molybdopterin FHE73_24510 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FHE73_24515 ENOG4105CVM Molybdenum cofactor synthesis domain protein FHE73_24525 ENOG4105D06 uba thif-type nad fad binding protein FHE73_24530 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FHE73_24555 ENOG41085GJ domain protein FHE73_24565 ENOG4105DWV Homoserine O-trans-acetylase FHE73_24575 ENOG4108B31 Spore germination protein FHE73_24600 ENOG4105C8T Leucyl-tRNA synthetase FHE73_24605 ENOG410605W Major Facilitator FHE73_24610 ENOG4107S91 Sodium hydrogen exchanger FHE73_24615 ENOG4105NCW Trka-c domain protein FHE73_24635 ENOG4105C19 ABC transporter FHE73_24655 ENOG4105N5T Radical SAM Protein FHE73_24690 ENOG4105E8V Alpha Beta Hydrolase Fold protein FHE73_24695 ENOG4108Z0R Transferase FHE73_24700 ENOG4105YVM Phosphoesterase, PA-phosphatase related FHE73_24705 ENOG4105BZF Glycosyl transferase (Group 1 FHE73_24715 ENOG4105EPU Molybdenum cofactor synthesis domain protein FHE73_24770 ENOG4105BZU Histidine kinase FHE73_24775 ENOG4105BZU Histidine kinase FHE73_24780 ENOG4107S9D Alpha beta hydrolase FHE73_24785 ENOG4107T7U Sulfatase FHE73_24810 ENOG4105D2X ABC transporter substrate-binding protein FHE73_24820 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FHE73_24880 ENOG41080TC multidrug resistance protein FHE73_24885 ENOG410839T multidrug resistance protein FHE73_24905 ENOG4108V2W Carbonate dehydratase FHE73_24910 ENOG4105D7V transposase FHE73_24915 ENOG4105C4M (Ubiquinol oxidase) subunit I FHE73_24920 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FHE73_24955 ENOG41087YS Phage shock protein A FHE73_24985 ENOG4105BZU Histidine kinase FHE73_24990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_25015 ENOG4108UGV hypoxanthine phosphoribosyltransferase FHE73_25020 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FHE73_25045 ENOG4107ZTW SNARE associated Golgi FHE73_25060 ENOG4105C19 ABC transporter FHE73_25065 ENOG41086D8 Transcriptional regulator FHE73_25075 ENOG4105CJ1 ABC, transporter FHE73_25085 ENOG41082BM Transcriptional regulator, arsr family FHE73_25130 ENOG4105C6Z Gluconate FHE73_25135 ENOG4105FDP GntR family transcriptional regulator FHE73_25155 ENOG41069H0 dihydroorotase EC 3.5.2.3 FHE73_25180 ENOG4105DTQ mandelate racemase muconate lactonizing FHE73_25190 ENOG4108IPT Naphthoate synthase FHE73_25195 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FHE73_25200 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FHE73_25205 ENOG4105E4F Isochorismate synthase FHE73_25210 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FHE73_25220 ENOG4105VEQ Cold shock protein FHE73_25275 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FHE73_25375 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FHE73_25410 ENOG4105KT7 mgtC SapB transporter FHE73_25415 ENOG4107PBV potassium channel FHE73_25435 ENOG4105WG9 Conserved Protein FHE73_25445 ENOG4105CHM Aminotransferase FHE73_25450 ENOG4108ZB6 transcriptional regulator AsnC family FHE73_25455 ENOG4105C5I Dehydrogenase FHE73_25460 ENOG4108MUZ hydrolase FHE73_25470 ENOG4105C87 Aminotransferase class I and II FHE73_25480 ENOG4105Y38 Kinase-associated protein B FHE73_25490 ENOG4107R3E Citrate transporter FHE73_25505 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FHE73_25510 ENOG4105KA0 thioesterase Superfamily protein FHE73_25525 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FHE73_25540 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FHE73_25545 ENOG41069ER domain protein FHE73_25560 ENOG4105CEP NADH dehydrogenase FHE73_25590 ENOG4105EWC Purine nucleoside phosphorylase FHE73_25615 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FHE73_25640 ENOG4108JJA ABC, transporter FHE73_25645 ENOG4105C4B ABC transporter, permease FHE73_25650 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FHE73_25680 ENOG41083MR nifu domain-containing protein FHE73_25695 ENOG4108W5N phosphatidylglycerophosphatase a FHE73_25710 ENOG4105DYS nad(p)h dehydrogenase (quinone) FHE73_25715 ENOG4105D4U had-superfamily hydrolase, subfamily iia FHE73_25730 ENOG4105CBT Fructose-1,6-bisphosphatase FHE73_25750 ENOG4105MMD transcriptional regulator FHE73_25755 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FHE73_25760 ENOG4107TXC Transcriptional regulator FHE73_25765 ENOG41090T1 Membrane FHE73_25790 ENOG4105FAA peptidase M23 FHE73_25795 ENOG4108YTE sporulation protein YunB FHE73_25800 ENOG4105KZD Domain of unknown function (DUF1805) FHE73_25805 ENOG4107R8B 5'-nucleotidase FHE73_25815 ENOG4105DIW FeS assembly protein SUFB FHE73_25820 ENOG4108UNV SUF system FeS assembly protein, NifU family FHE73_25825 ENOG4105C9B Cysteine desulfurase FHE73_25830 ENOG4105JRK feS assembly protein SufD FHE73_25835 ENOG4105C3K feS assembly ATPase SufC FHE73_25840 ENOG4105D01 (LipO)protein FHE73_25845 ENOG4105D01 (LipO)protein FHE73_25850 ENOG4108UMI ABC transporter, permease FHE73_25855 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FHE73_25880 ENOG41080E8 Transcriptional regulator, Spx MgsR family FHE73_25900 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FHE73_25930 ENOG4108W8B Beta-lactamase domain protein FHE73_25935 ENOG4105C1G acyl-Coa dehydrogenase FHE73_25940 ENOG4105CHU acetyl-coa acetyltransferase FHE73_25955 ENOG4105DZ1 carboxypeptidase FHE73_25975 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FHE73_25990 ENOG4108SUT Major Facilitator Superfamily FHE73_25995 ENOG4107R7I amino acid FHE73_26010 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FHE73_26020 ENOG4107AYK membrAne FHE73_26065 ENOG4107ZTW SNARE associated Golgi FHE73_26075 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FHE73_26080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_26085 ENOG4105BZU Histidine kinase FHE73_26100 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FHE73_26110 ENOG4105C8Q Methyl-accepting chemotaxis FHE73_26115 ENOG4105C8Q Methyl-accepting chemotaxis FHE73_26120 ENOG4105VG1 fes assembly suf system protein FHE73_26125 ENOG4105D4Y metalloprotease FHE73_26130 ENOG4105C2I pirin domain protein FHE73_26145 ENOG4107S91 Sodium hydrogen exchanger FHE73_26150 ENOG4105NCW Trka-c domain protein FHE73_26165 ENOG4108RMU ferritin dps family protein FHE73_26180 ENOG4108URH decarboxylase FHE73_26190 ENOG41090A1 ferritin FHE73_26200 ENOG4105D9N nucleoside FHE73_26205 ENOG4105D9N nucleoside FHE73_26220 ENOG4108RYK Nad-dependent epimerase dehydratase FHE73_26235 ENOG4105CV8 reductase FHE73_26240 ENOG4105F27 Major Facilitator FHE73_26245 ENOG4105KVH Transcriptional regulator FHE73_26260 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FHE73_26265 ENOG4105D4A Cell wall formation (By similarity) FHE73_26285 ENOG4105WMR Protein CrcB homolog FHE73_26290 ENOG4105WMR Protein CrcB homolog FHE73_26310 ENOG4105C5H ABC transporter FHE73_26315 ENOG4108MK9 spermidine N(1)-acetyltransferase FHE73_26325 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FHE73_26335 ENOG4108W2Y isochorismatase FHE73_26355 ENOG4108IPW abc transporter atp-binding protein FHE73_26360 ENOG4105CM4 permease protein FHE73_26395 ENOG4106A3M Cytochrome p-450 FHE73_26405 ENOG4106A3M Cytochrome p-450 FHE73_26410 ENOG4105YA8 Transcriptional regulator FHE73_26455 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FHE73_26465 ENOG4105XZU Preprotein translocase, subunit SecG FHE73_26470 ENOG41067MG lrgb family FHE73_26490 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FHE73_26520 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHE73_26540 ENOG41090VF Stage v sporulation protein ac FHE73_26545 ENOG4105CZ3 stage V sporulation protein ad FHE73_26560 ENOG4108QY0 Membrane FHE73_26565 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FHE73_26580 ENOG4105KRI phosphocarrier protein (HPr FHE73_26590 ENOG4105CHW UPF0052 protein FHE73_26595 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FHE73_26600 ENOG4108Z4K mutator MutT protein FHE73_26610 ENOG4105C3M thioredoxin reductase FHE73_26620 ENOG4108S4C acetyltransferase FHE73_26640 ENOG41086DT Membrane protein of unknown function FHE73_26650 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FHE73_26670 ENOG4107TXC Transcriptional regulator FHE73_26690 ENOG4105DUM transcriptional regulator, lysR family FHE73_26700 ENOG4108WS4 fmn reductase FHE73_26715 ENOG4105BZ1 (ABC) transporter FHE73_26725 ENOG4105CN1 protease FHE73_26730 ENOG4105CRP Part of the ABC transporter FtsEX involved in FHE73_26735 ENOG4105CAK Cell division ATP-binding protein ftsE FHE73_26760 ENOG4105MS2 ribosomal subunit Interface protein FHE73_26765 ENOG4105VEQ Cold shock protein FHE73_26770 ENOG41081UC Inherit from COG: Competence protein FHE73_26800 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase FHE73_26805 ENOG4105XSJ toxin secretion phage lysis holin FHE73_27010 ENOG4108C33 Resolvase FHE73_27025 ENOG4105KVH Transcriptional regulator FHE73_27035 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FHE73_27040 ENOG4108KGH TRANSCRIPTIONal FHE73_27045 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FHE73_27050 ENOG4105C6Y Udp-glucose 6-dehydrogenase FHE73_27055 ENOG4105ESV Glycosyl transferase, family 4 FHE73_27065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FHE73_27085 ENOG4105F8D glycoside hydrolase family 4 FHE73_27090 ENOG4105VCP PTS System FHE73_27095 ENOG4105CK1 PTS System FHE73_27105 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FHE73_27115 ENOG4105VCP PTS System FHE73_27125 ENOG4105VZJ PTS System FHE73_27145 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase FHE73_27150 ENOG4105ECB domain protein FHE73_27155 ENOG4107RSM transcriptional regulator FHE73_27185 ENOG4105DAA L-lactate FHE73_27195 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FHE73_27210 ENOG4105E0M Sulfatase FHE73_27240 ENOG4107R8N Glycosyl transferase, family 2 FHE73_27245 ENOG4105C94 Transporter FHE73_27255 ENOG41069ER domain protein FHE73_27280 ENOG4105KBK Zinc finger, swim domain protein FHE73_27285 ENOG4105C0D helicase FHE73_27315 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FHE73_27325 ENOG4107RBB ABC transporter, permease FHE73_27330 ENOG4105C19 ABC transporter FHE73_27340 ENOG4105CXY transporter FHE73_27355 ENOG4105BZU Histidine kinase FHE73_27360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_27365 ENOG4105CMR udp-glucose 4-epimerase FHE73_27375 ENOG4108KGH TRANSCRIPTIONal FHE73_27390 ENOG4107QRS glycosyltransferase group 2 family protein FHE73_27395 ENOG4107T8Q Glycosyl transferase (Group 1 FHE73_27405 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) FHE73_27415 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FHE73_27425 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FHE73_27430 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FHE73_27435 ENOG4107YJ4 chain length determinant protein FHE73_27440 ENOG4105HTX biosynthesis protein FHE73_27445 ENOG4107YJ4 chain length determinant protein FHE73_27460 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FHE73_27470 ENOG4105FRN stage II sporulation protein FHE73_27485 ENOG4105DY9 regulatoR FHE73_27505 ENOG4106778 Protein of unknown function (DUF1146) FHE73_27510 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FHE73_27515 ENOG4105C8S subunit m FHE73_27520 ENOG4105D65 subunit l FHE73_27545 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FHE73_27550 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FHE73_27560 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FHE73_27565 ENOG4105BZU Histidine kinase FHE73_27620 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FHE73_27625 ENOG41062M3 atp synthase FHE73_27645 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FHE73_27650 ENOG4108UIC UPF0340 protein FHE73_27655 ENOG4108YZG isomerase FHE73_27670 ENOG4108VGI doxx family FHE73_27675 ENOG4107XC4 flavin reductase domain protein, FMN-binding FHE73_27690 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FHE73_27700 ENOG4108ZXQ stage ii sporulation protein r FHE73_27705 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FHE73_27710 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FHE73_27715 ENOG4107104 thymidine kinase FHE73_27725 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FHE73_27730 ENOG4105CBT Fructose-1,6-bisphosphatase FHE73_27735 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FHE73_27755 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FHE73_27770 ENOG4105C1G acyl-Coa dehydrogenase FHE73_27775 ENOG4105C1G acyl-Coa dehydrogenase FHE73_27780 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FHE73_27790 ENOG4105DF6 Fe-S oxidoreductase FHE73_27805 ENOG4105BZU Histidine kinase FHE73_27820 ENOG4105D4Y metalloprotease FHE73_27830 ENOG4105BZU Histidine kinase FHE73_27835 ENOG4105KCT ABC transporter FHE73_27840 ENOG4108M15 ABC transporter FHE73_27845 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FHE73_27855 ENOG4105IIU Aminopeptidase FHE73_27875 ENOG4105JVQ RNA Polymerase FHE73_27885 ENOG410684U Domain of unknown function (DUF1934) FHE73_27910 ENOG4105CYW agmatinase FHE73_27920 ENOG4105DXB Major Facilitator superfamily FHE73_27925 ENOG4107SWG transcriptional regulator MERR family FHE73_27930 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FHE73_27935 ENOG4105BZ4 penicillin-binding protein FHE73_27940 ENOG4108XFG YwhD family FHE73_27945 ENOG4108Z4T Peptidase M50 FHE73_27950 ENOG41069HH 4-oxalocrotonate tautomerase FHE73_27955 ENOG4105DCI Phosphohydrolase FHE73_27960 ENOG4108MES Periplasmic binding protein FHE73_27965 ENOG4105E0A ABC, transporter FHE73_27970 ENOG4105EHG Permease protein FHE73_27975 ENOG4105DQ5 transport system permease protein FHE73_27985 ENOG4108VCI transcription factor, rsfa family FHE73_27990 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FHE73_27995 ENOG4108IJ2 phosphate acetyltransferase FHE73_28000 ENOG4107UEZ chlorite dismutase FHE73_28010 ENOG4108VKI Cell wall hydrolase FHE73_28030 ENOG4107SVH Potassium channel protein FHE73_28040 ENOG410667J hydrolase FHE73_28045 ENOG4105VCH membrane FHE73_28055 ENOG4108TU7 Inherit from COG: (ABC) transporter FHE73_28060 ENOG4105CJ1 ABC, transporter FHE73_28065 ENOG41090WU lipolytic protein G-D-S-L family FHE73_28080 ENOG4105D6E homoserine dehydrogenase FHE73_28085 ENOG4105CVG Homoserine O-transsuccinylase FHE73_28100 ENOG4108Y4K DNA-binding transcriptional activator FHE73_28110 ENOG4105WH1 Two component transcriptional regulator luxr family FHE73_28115 ENOG4105BZU Histidine kinase FHE73_28120 ENOG4105DWF phosphomethylpyrimidine kinase FHE73_28125 ENOG4105BZU Histidine kinase FHE73_28130 ENOG4105VCD cytoplasmic protein FHE73_28135 ENOG4105D22 carbon starvation protein FHE73_28140 ENOG4105DY9 regulatoR FHE73_28145 ENOG41079KZ Major Facilitator Superfamily FHE73_28160 ENOG4105CG5 Glycosyl transferase (Group 1 FHE73_28170 ENOG4105EN6 Membrane FHE73_28175 ENOG4106YBV Methyl-accepting chemotaxis FHE73_28185 ENOG4108S4H thioesterase Superfamily protein FHE73_28190 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FHE73_28205 ENOG4105K64 Glycosyl transferase, family 2 FHE73_28215 ENOG4105EJV Membrane FHE73_28220 ENOG4105CKK Glycosyl transferase, family 2 FHE73_28225 ENOG4105C5H ABC transporter FHE73_28230 ENOG41067SE Tetr family transcriptional regulator FHE73_28240 ENOG4105E0X reductase FHE73_28245 ENOG4106F5Q Membrane FHE73_28260 ENOG4108NEV two component transcriptional regulator, LytTR family FHE73_28265 ENOG4108HRK Histidine kinase FHE73_28270 ENOG4107RGD Major Facilitator superfamily FHE73_28290 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FHE73_28300 ENOG4105IW1 AmiS UreI transporter FHE73_28310 ENOG4105CMR udp-glucose 4-epimerase FHE73_28315 ENOG4108UT2 hemolysin iii FHE73_28325 ENOG4105C1J atp-dependent rna helicase FHE73_28330 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FHE73_28350 ENOG4105BZU Histidine kinase FHE73_28365 ENOG4105C0H protease FHE73_28370 ENOG4105Q2H domain protein FHE73_28385 ENOG4105BZU Histidine kinase FHE73_28390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FHE73_28415 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FHE73_28420 ENOG4105CDU Replicative dna helicase FHE73_28430 ENOG4105BZR domain protein FHE73_28435 ENOG4108XMW Membrane FHE73_28445 ENOG4108UUM single-stranded DNA-binding protein FHE73_28455 ENOG4105C3G gtp-binding protein FHE73_28460 ENOG4105VDK protein, conserved in bacteria FHE73_28465 ENOG4105D8X mechanosensitive ion channel FHE73_28470 ENOG4108ZDA Sporulation protein YyaC FHE73_28475 ENOG4105FA0 parb-like partition protein FHE73_28480 ENOG4107QJE Chromosome Partitioning Protein FHE73_28495 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FHE73_28500 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FHE73_28510 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FHE73_28540 ENOG4108R5S membrane FHE73_28545 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FHE73_28550 ENOG41069DP small acid-soluble spore protein FHE73_28560 ENOG4108QY0 Membrane FHE73_28590 ENOG4105CFF transcriptional regulator FHE73_28685 ENOG4105K70 DNA-binding protein FHE73_28765 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FHE73_28775 ENOG4108XG2 Histidine kinase FHE73_28780 ENOG4105CAQ asparagine synthetase FHE73_28785 ENOG4108RZE Tetr family transcriptional regulator FHE73_28815 ENOG4108IBT Inherit from COG: transposase FHE73_28845 ENOG4107U9B transcriptional regulator FHE73_28850 ENOG4108UMN azlc family FHE73_28855 ENOG4105KMT branched-chain amino acid FHE73_28875 ENOG4105E4C Lytic transglycosylase catalytic FHE73_28890 ENOG4107JM4 Tetratricopeptide repeat FHE73_29055 ENOG4105CNU cell division protein FtsK FHE73_29185 ENOG4105D7V transposase FHE73_29225 ENOG41080UQ Transcriptional regulator FHE73_29230 ENOG4108RWP Major Facilitator Superfamily protein FHE73_29310 ENOG4105DHF Membrane FHE73_29405 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FHE73_29425 ENOG4105K70 DNA-binding protein FHE73_29435 ENOG4105D7V transposase FHE73_29440 ENOG4105KRN Transcriptional regulator, abrb family FHE73_29450 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FHE73_29520 ENOG4105NA0 Transcriptional regulator FHE73_29540 ENOG4105C8Q Methyl-accepting chemotaxis FHE73_29560 ENOG41075H3 AraC family transcriptional regulator FHE73_29615 ENOG4105KNA -acetyltransferase FHE73_29625 ENOG4107QJQ Mate efflux family protein FHE73_29635 ENOG4108MES Periplasmic binding protein FHE73_29640 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) FHE73_29645 ENOG4108VXD carboxy-peptidase FHE73_29705 ENOG4106AKJ FHE73_29760 ENOG4108M1A Chitin-binding protein FHE73_29835 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FHE73_29845 ENOG4108JJA ABC, transporter FHE73_29850 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FHE73_29860 ENOG4105CZV ABC transporter FHE73_29925 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FHE73_29965 ENOG4105CJ1 ABC, transporter FHE73_29970 ENOG4105BZ1 (ABC) transporter FHE73_29990 ENOG41067FT ParB-like nuclease domain FHE73_30020 ENOG4105TRI Hydrolase FHE73_30060 ENOG4105IBP Cyclic peptide transporter FHE73_30065 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FHE73_30085 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FHE73_30090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FHE73_30105 ENOG4105C1G acyl-Coa dehydrogenase FHE73_30115 ENOG4105CEY Amp-dependent synthetase and ligase FHE73_30125 ENOG4105C0W non-ribosomal peptide synthetase FHE73_30125 ENOG4105C0W non-ribosomal peptide synthetase FHE73_30135 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FHE73_30150 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FHE73_30165 ENOG4105CKK Glycosyl transferase, family 2 FHE73_30175 ENOG4105D7V transposase FHE73_30185 ENOG41087PP glycosyltransferase MGT family FHE73_30190 ENOG4105KNA -acetyltransferase FHE73_30205 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FHE73_30255 ENOG4107SET aldo keto reductase FHE73_30290 ENOG4105D2T synthase FHE73_30305 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) FHE73_30310 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FHE73_30315 ENOG4105C1B dTDP-glucose 4-6-dehydratase FHE73_30320 ENOG4105C5E polysaccharide biosynthesis protein FHE73_30340 ENOG4105CHR reductase FHE73_30350 ENOG4105D2T synthase FHE73_30355 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FHE73_30395 ENOG4108IMY Transcriptional regulator FHE73_30420 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FHE73_30425 ENOG4108UT6 Transferase hexapeptide repeat containing protein FHE73_30435 ENOG4105K64 Glycosyl transferase, family 2 FHE73_30440 ENOG4105E39 Enoyl-CoA hydratase FHE73_30585 ENOG4105PKS Excinuclease abc c subunit domain protein FHE73_30685 ENOG4105CAT Cytidine monophosphate kinase FHE73_30690 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) FHE73_30700 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)