locus-tag class description AC241_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AC241_00015 ENOG410848D S4 domain protein YaaA AC241_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AC241_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AC241_00100 ENOG4105ZMH deoxynucleoside kinase AC241_00110 ENOG4105GTG Isochorismatase AC241_00120 ENOG4108Z6B deaminase AC241_00125 ENOG4105C6E dna polymerase iii AC241_00145 ENOG41067KS pro-sigma K processing AC241_00180 ENOG4105CXN decarboxylase AC241_00190 ENOG4105FA2 dna polymerase iii AC241_00195 ENOG4105MA4 psp1 domain protein AC241_00205 ENOG41060K3 Methyltransferase AC241_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AC241_00220 ENOG4105KRN Transcriptional regulator, abrb family AC241_00225 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AC241_00230 ENOG4105F8V Hydrolase, tatD family AC241_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AC241_00245 ENOG4105XFA sporulation peptidase YabG AC241_00250 ENOG4105W42 Veg protein AC241_00265 ENOG4105DFT pur operon repressor AC241_00270 ENOG4105KME endoribonuclease L-psp AC241_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AC241_00290 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AC241_00300 ENOG4108JA2 transcriptioN-repair coupling factor AC241_00305 ENOG4108M14 stage v sporulation protein t AC241_00315 ENOG4108IY2 MazG family AC241_00320 ENOG41082I2 s4 domain protein AC241_00325 ENOG4105VYY sporulation protein yabp AC241_00340 ENOG41060GV RNA binding s1 domain protein AC241_00360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AC241_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase AC241_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AC241_00385 ENOG4105C6T cysteine synthase AC241_00390 ENOG4105CRQ synthase (Component I) AC241_00395 ENOG4105DDQ anthranilate synthase AC241_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AC241_00405 ENOG4105EEI dihydropteroate synthase AC241_00410 ENOG4105KRF dihydroneopterin aldolase AC241_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AC241_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AC241_00515 ENOG4108Z0C Uvrb UvrC protein AC241_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AC241_00540 ENOG4105CTP PilT protein domain protein AC241_00560 ENOG4105D7W serine acetyltransferase AC241_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 AC241_00580 ENOG4105M0M Tetracycline resistance protein AC241_00585 ENOG4105QIV RNA polymerase AC241_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AC241_00620 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AC241_00625 ENOG4107Y49 methyltransferase AC241_00635 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AC241_00640 ENOG4105XPM ribosomal protein AC241_00745 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AC241_00770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AC241_00780 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AC241_00790 ENOG41067V7 50S ribosomal protein L36 AC241_00815 ENOG4108JJB ABC transporter AC241_00820 ENOG4108JJB ABC transporter AC241_00825 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AC241_00830 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AC241_00855 ENOG4105D1F ATP-binding protein AC241_00870 ENOG4108NMV polysaccharide deacetylase AC241_00950 ENOG4105C8B TIGR00159 family AC241_00955 ENOG4107U5W ybbr family AC241_00970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AC241_00990 ENOG4108PSK reductase AC241_00995 ENOG4108UMI ABC transporter, permease AC241_01000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AC241_01005 ENOG4105D01 (LipO)protein AC241_01010 ENOG4105CB2 alcohol dehydrogenase AC241_01020 ENOG4105IQ5 FAD linked oxidase domain protein AC241_01035 ENOG4105C2C drug resistance transporter, Bcr CflA AC241_01055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AC241_01060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AC241_01065 ENOG4105C3U ABC transporter AC241_01070 ENOG4108JQ7 (ABC) transporter AC241_01100 ENOG4108J59 Extracellular solute-binding protein, family 5 AC241_01105 ENOG4108J59 Extracellular solute-binding protein, family 5 AC241_01125 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AC241_01135 ENOG4105E0C molybdate abc transporter AC241_01140 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AC241_01145 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AC241_01180 ENOG4105F6E Acyl-transferase AC241_01200 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AC241_01220 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AC241_01245 ENOG4105C5H ABC transporter AC241_01255 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AC241_01265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AC241_01270 ENOG4105C3U ABC transporter AC241_01275 ENOG4108JQ7 (ABC) transporter AC241_01280 ENOG410667J hydrolase AC241_01310 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AC241_01315 ENOG4105ERH Fumarylacetoacetate hydrolase AC241_01330 ENOG4105CUB amino acid AC241_01335 ENOG4108SC4 )-transporter AC241_01340 ENOG4105CPF Cell wall formation (By similarity) AC241_01345 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AC241_01370 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AC241_01375 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AC241_01385 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AC241_01490 ENOG4105K8N protein family UPF0079, ATPase AC241_01495 ENOG41072GX Peptidase M22 Glycoprotease AC241_01500 ENOG410801F ribosomal-protein-alanine acetyltransferase AC241_01505 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AC241_01510 ENOG4105C5H ABC transporter AC241_01525 ENOG4108TYN CAAX amino terminal protease family protein AC241_01545 ENOG4105C7N Xanthine uracil vitamin C permease AC241_01555 ENOG4105BZU Histidine kinase AC241_01580 ENOG4107ZXU DSBA oxidoreductase AC241_01600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC241_01645 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AC241_01655 ENOG4108SHN Glycosyl transferase, family 2 AC241_01675 ENOG4105SX7 Transporter AC241_01700 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AC241_01705 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AC241_01710 ENOG4105C83 adenylosuccinate lyase AC241_01720 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AC241_01745 ENOG4108V3E phosphoribosylglycinamide formyltransferase AC241_01750 ENOG4105DC1 bifunctional purine biosynthesis protein purh AC241_01755 ENOG4105C12 Phosphoribosylglycinamide synthetase AC241_01765 ENOG4105EGI Transcriptional regulator AC241_01790 ENOG4105C4R Atp-dependent dna helicase AC241_01815 ENOG4108W2Y isochorismatase AC241_01820 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AC241_01825 ENOG4108UMI ABC transporter, permease AC241_01830 ENOG4105D01 (LipO)protein AC241_01850 ENOG410834F Transcriptional regulator AC241_01855 ENOG4107I77 yiaA/B two helix domain AC241_01875 ENOG4105CBD Diacylglycerol kinase AC241_01885 ENOG4108JPW Aminotransferase AC241_01895 ENOG4105C26 Dehydrogenase AC241_01900 ENOG4105KPY Small multidrug resistance protein AC241_01920 ENOG4105D9N nucleoside AC241_01925 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AC241_01935 ENOG4108W15 Protein of unknown function (DUF1456) AC241_01950 ENOG4105DTQ mandelate racemase muconate lactonizing AC241_01960 ENOG4105DFD Na H antiporter AC241_01985 ENOG4105D3R alkyl hydroperoxide reductase AC241_01990 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AC241_01995 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AC241_02000 ENOG4107W7X Aldolase AC241_02005 ENOG4105EHG Permease protein AC241_02010 ENOG4105DQ5 transport system permease protein AC241_02015 ENOG4108V5C ABC transporter AC241_02025 ENOG4105CAY ferredoxin--nadp reductase AC241_02045 ENOG4106UIA AC241_02050 ENOG4106UIA AC241_02065 ENOG4105BZU Histidine kinase AC241_02085 ENOG410756H nucleotidyltransferase AC241_02095 ENOG4105DQ6 Transposase AC241_02100 ENOG4105D2S major facilitator superfamily AC241_02115 ENOG4105E5Q amino acid AbC transporter AC241_02120 ENOG4105EAB amino acid AbC transporter AC241_02130 ENOG4105C8Q Methyl-accepting chemotaxis AC241_02145 ENOG4105DBV ornithine carbamoyltransferase AC241_02155 ENOG4105C5B carbamate kinase AC241_02160 ENOG4108W63 CRP FNR family transcriptional regulator AC241_02170 ENOG4105DNP FAD linked oxidase domain protein AC241_02180 ENOG4105CI1 PTS System AC241_02195 ENOG4105C9U ATP-dependent DNA helicase RecQ AC241_02210 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AC241_02230 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AC241_02245 ENOG4105C5H ABC transporter AC241_02275 ENOG41062JF Transcriptional regulator AC241_02290 ENOG4105DEU major facilitator superfamily AC241_02305 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AC241_02320 ENOG4108N0M stress protein AC241_02325 ENOG4106FN3 tellurium resistance protein AC241_02330 ENOG4106FN3 tellurium resistance protein AC241_02335 ENOG4107TS3 membrane protein, TerC AC241_02340 ENOG4108TTB tellurium resistance protein AC241_02355 ENOG41068PA UPF0435 protein AC241_02360 ENOG4105KJF protein tyrosine phosphatase AC241_02370 ENOG4107U9T Pfam:Ribonuclease_BN AC241_02375 ENOG4105C59 p-type ATPase AC241_02380 ENOG4108IPJ Membrane AC241_02400 ENOG4107ZTW SNARE associated Golgi AC241_02415 ENOG410606W general stress protein AC241_02420 ENOG4105UPD Calcium Proton AC241_02455 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AC241_02465 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AC241_02475 ENOG4108JUB Transcriptional regulator AC241_02485 ENOG4108IQI permease AC241_02525 ENOG4108A04 Beta-lactamase AC241_02540 ENOG4107R51 Glycosyl transferase, family 2 AC241_02545 ENOG4107QQG Dehydrogenase AC241_02550 ENOG4105C3I Nad-dependent epimerase dehydratase AC241_02555 ENOG4105CKK Glycosyl transferase, family 2 AC241_02570 ENOG4105F1A Pyruvate formate-lyase AC241_02590 ENOG4105CI2 imidazolone-5-propionate hydrolase AC241_02595 ENOG4105ECP epimerase AC241_02625 ENOG41067AE Membrane-bound metal-dependent hydrolase AC241_02630 ENOG4105CEN a g-specific adenine glycosylase AC241_02635 ENOG4106BXE AC241_02655 ENOG4105BZ1 (ABC) transporter AC241_02660 ENOG4107NBY Membrane AC241_02665 ENOG4105CBC glutamate synthase AC241_02675 ENOG4108IUW ABC transporter AC241_02695 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AC241_02700 ENOG4105G5W regulator Fur family AC241_02820 ENOG4108JQC penicillin-binding protein 1A AC241_02825 ENOG4108R9S DSBA oxidoreductase AC241_02835 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AC241_02845 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AC241_02860 ENOG4105CYN Serine protein kinase AC241_02880 ENOG4108MK9 spermidine N(1)-acetyltransferase AC241_02885 ENOG4105C94 Transporter AC241_02900 ENOG4105DZ6 Band 7 protein AC241_02910 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AC241_02915 ENOG4108V9W transcriptional regulatory protein AC241_02920 ENOG4105D4T Citrate transporter AC241_02945 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AC241_02950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AC241_02955 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component AC241_02960 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AC241_02965 ENOG4105BZ7 extracellular solute-binding protein family 1 AC241_02970 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AC241_02975 ENOG4108STX response regulator AC241_02980 ENOG4105US7 Histidine kinase AC241_03005 ENOG4108MRH transcriptional regulatory protein AC241_03015 ENOG4105C6K Malic enzyme AC241_03025 ENOG4108UZ3 Transporter AC241_03030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC241_03040 ENOG4105BZU Histidine kinase AC241_03045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_03060 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AC241_03065 ENOG4108JB9 formate dehydrogenase AC241_03085 ENOG4105CUB amino acid AC241_03100 ENOG4105C59 p-type ATPase AC241_03105 ENOG4105DAP Nicotinate phosphoribosyltransferase AC241_03135 ENOG41073R8 VanW family AC241_03140 ENOG4108KGH TRANSCRIPTIONal AC241_03145 ENOG4105D9N nucleoside AC241_03150 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AC241_03155 ENOG4105C37 (CBS) domain AC241_03160 ENOG4108IJ0 Aspartate ammonia-lyase AC241_03165 ENOG4105DQ6 Transposase AC241_03175 ENOG4105DAA L-lactate AC241_03190 ENOG4105DUX Transporter AC241_03195 ENOG4108MES Periplasmic binding protein AC241_03200 ENOG4105DQ5 transport system permease protein AC241_03205 ENOG4108IHU transport system permease protein AC241_03210 ENOG4105E0A ABC, transporter AC241_03225 ENOG4105EXW epimerase dehydratase AC241_03230 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AC241_03240 ENOG4107T89 von Willebrand factor, type A AC241_03245 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AC241_03250 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AC241_03260 ENOG4105BZU Histidine kinase AC241_03270 ENOG4105DQ6 Transposase AC241_03275 ENOG4105D5Q Arginine ornithine antiporter AC241_03280 ENOG4107414 GntR family transcriptional regulator AC241_03285 ENOG4105C5Y PTS System AC241_03290 ENOG4105CG3 alpha amylase, catalytic region AC241_03305 ENOG4105E1K spore germination protein AC241_03310 ENOG4105CRN Aminoglycoside phosphotransferase AC241_03315 ENOG4105BZG amino acid carrier protein AC241_03325 ENOG4105CDA abc transporter atp-binding protein AC241_03330 ENOG4105CT1 (ABC) transporter AC241_03335 ENOG4105EAD ABC transporter AC241_03340 ENOG4105DRP amino acid AbC transporter AC241_03345 ENOG4108IQI permease AC241_03370 ENOG4105D29 Helix-turn-helix type 11 domain protein AC241_03375 ENOG4105NAE bifunctional deaminase-reductase domain protein AC241_03380 ENOG4105BZU Histidine kinase AC241_03395 ENOG4105CHH sulfate transporter AC241_03400 ENOG41068KF Universal stress protein AC241_03410 ENOG4108J59 Extracellular solute-binding protein, family 5 AC241_03420 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AC241_03425 ENOG4108JQ7 (ABC) transporter AC241_03435 ENOG4105CXY transporter AC241_03440 ENOG41067TZ transcriptional regulator, MarR family AC241_03445 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC241_03450 ENOG4105ETE Transcriptional regulator (LacI family AC241_03455 ENOG4108RVA ribokinase AC241_03465 ENOG4105C2J ABC transporter AC241_03470 ENOG4105CNN ABC, transporter AC241_03475 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AC241_03480 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AC241_03520 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) AC241_03550 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AC241_03555 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AC241_03560 ENOG41069ER domain protein AC241_03565 ENOG4105VZ8 Transcriptional regulator AC241_03570 ENOG4107D63 AC241_03585 ENOG4105DUX Transporter AC241_03605 ENOG4105C85 amino acid AC241_03610 ENOG4105C7N Xanthine uracil vitamin C permease AC241_03625 ENOG4105MA6 gCN5-related N-acetyltransferase AC241_03645 ENOG4105CCU oxidase (Subunit III) AC241_03650 ENOG4105BZ9 Cytochrome C oxidase, subunit I AC241_03655 ENOG4105E2S oxidase) subunit II AC241_03675 ENOG4106CAD Protein of unknown function (DUF3311) AC241_03680 ENOG4105E1V na solute symporter AC241_03695 ENOG4108NHD germination protein AC241_03705 ENOG4105CE1 Ferrous iron transport protein b AC241_03710 ENOG4105CE1 Ferrous iron transport protein b AC241_03715 ENOG4105CE1 Ferrous iron transport protein b AC241_03720 ENOG4105CVA phosphate AC241_03725 ENOG4105C8U phosphate abc transporter AC241_03730 ENOG4105E2Z phosphate ABC transporter (Permease AC241_03860 ENOG41080XQ Signal transduction protein with cbs domains AC241_03885 ENOG4105ETU transcriptional activator (TenA AC241_03895 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AC241_03905 ENOG4108VEU Thiamine monophosphate synthase AC241_03910 ENOG41080HI glycine oxidase AC241_03925 ENOG4105D06 uba thif-type nad fad binding protein AC241_03930 ENOG4105DWF phosphomethylpyrimidine kinase AC241_03980 ENOG4108INS Transcriptional regulator AC241_04005 ENOG4105C19 ABC transporter AC241_04015 ENOG4105DQ6 Transposase AC241_04025 ENOG4105CNN ABC, transporter AC241_04030 ENOG4105C2J ABC transporter AC241_04040 ENOG4105C7N Xanthine uracil vitamin C permease AC241_04050 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AC241_04065 ENOG4105K63 Thioredoxin AC241_04085 ENOG4108B31 Spore germination protein AC241_04105 ENOG4107Y03 Nitroreductase AC241_04110 ENOG4105ED1 spovr family AC241_04125 ENOG4105XTG Pfam:DUF156 AC241_04130 ENOG4105VFE sira family AC241_04135 ENOG4107TPS domain protein AC241_04140 ENOG4105VFE sira family AC241_04145 ENOG41085GJ domain protein AC241_04155 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AC241_04160 ENOG41087NI Sulfite exporter TauE/SafE AC241_04170 ENOG4108KGH TRANSCRIPTIONal AC241_04195 ENOG4105EMD TRANSCRIPTIONal AC241_04200 ENOG4105VCP PTS System AC241_04205 ENOG4105VZJ PTS System AC241_04225 ENOG41069ER domain protein AC241_04230 ENOG4107RBB ABC transporter, permease AC241_04235 ENOG4105C19 ABC transporter AC241_04270 ENOG4105WEF catalase AC241_04295 ENOG4107T5V SNARE associated Golgi AC241_04330 ENOG4105CUB amino acid AC241_04335 ENOG4107RWR Sodium hydrogen exchanger AC241_04345 ENOG4106KNT transcriptional regulator AC241_04385 ENOG4108YXU transcriptional regulator AsnC family AC241_04390 ENOG4105CH7 arginosuccinase AC241_04400 ENOG4105VUF Transcriptional regulator AC241_04405 ENOG4105KPY Small multidrug resistance protein AC241_04450 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AC241_04455 ENOG4105E5W Transporter AC241_04465 ENOG4107RKG DJ-1/PfpI family AC241_04475 ENOG4105D5Q Arginine ornithine antiporter AC241_04480 ENOG4105C26 Dehydrogenase AC241_04490 ENOG4105BZ1 (ABC) transporter AC241_04495 ENOG4105BZ1 (ABC) transporter AC241_04505 ENOG4105DRP amino acid AbC transporter AC241_04510 ENOG4105CDA abc transporter atp-binding protein AC241_04525 ENOG410839P AC241_04560 ENOG4107FQX Alpha-acetolactate decarboxylase AC241_04580 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AC241_04585 ENOG4105D4P Coproporphyrinogen iii oxidase AC241_04600 ENOG4105CHH sulfate transporter AC241_04625 ENOG4105CGU Enoyl-CoA hydratase AC241_04645 ENOG4105DER m42 family AC241_04665 ENOG4105CTU Proline racemase AC241_04670 ENOG4105CIF Ornithine Cyclodeaminase AC241_04690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AC241_04700 ENOG4108JQ7 (ABC) transporter AC241_04735 ENOG4105CSH Transporter AC241_04745 ENOG4108MRH transcriptional regulatory protein AC241_04755 ENOG4105M6F mutator MutT protein AC241_04770 ENOG4105CDU Replicative dna helicase AC241_04795 ENOG4105ST3 Transcriptional regulator AC241_04800 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC241_04805 ENOG4105ENX hydrolase AC241_04830 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC241_04845 ENOG4105C19 ABC transporter AC241_04850 ENOG4105CJZ response regulator AC241_04860 ENOG4105F6J Alpha beta hydrolase fold AC241_04910 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AC241_04920 ENOG4105F27 Major Facilitator AC241_04925 ENOG4105WAB arsR family transcriptional regulator AC241_04935 ENOG4105CMT Dihydroxyacetone kinase AC241_04945 ENOG4105CMT Dihydroxyacetone kinase AC241_04950 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AC241_04955 ENOG410847I Transcriptional regulator, BadM Rrf2 family AC241_05025 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AC241_05065 ENOG4105WN5 stage II sporulation protein AC241_05075 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_05085 ENOG4108MJI response regulator AC241_05090 ENOG4105BZU Histidine kinase AC241_05095 ENOG4105BZU Histidine kinase AC241_05120 ENOG4105K8R UPF0145 protein AC241_05130 ENOG4105DJ2 Major Facilitator Superfamily AC241_05135 ENOG4105C6F GntR Family Transcriptional Regulator AC241_05145 ENOG4107QHE Choloylglycine hydrolase AC241_05165 ENOG4107VRP DNA repair exonuclease AC241_05170 ENOG4106D4I domain protein AC241_05185 ENOG410829K Lysine exporter protein (Lyse ygga) AC241_05205 ENOG4108MUZ hydrolase AC241_05220 ENOG4105F0F Oxalate decarboxylase AC241_05225 ENOG41067QW Transcriptional regulator AC241_05230 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AC241_05245 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AC241_05265 ENOG4105EMN RNA polymerase sigma factor AC241_05280 ENOG4105DQ6 Transposase AC241_05290 ENOG4105EEM helicase AC241_05300 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AC241_05330 ENOG4105K59 histidine triad (HIT) protein AC241_05360 ENOG410905X membrane-flanked domain protein AC241_05365 ENOG4105CKV Membrane AC241_05400 ENOG410905X membrane-flanked domain protein AC241_05405 ENOG4105CKV Membrane AC241_05410 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AC241_05415 ENOG4105BZ4 penicillin-binding protein AC241_05425 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AC241_05430 ENOG4105C1Q protoporphyrinogen oxidase AC241_05450 ENOG4105NA0 Transcriptional regulator AC241_05465 ENOG4105ECB domain protein AC241_05495 ENOG4105D29 Helix-turn-helix type 11 domain protein AC241_05505 ENOG4106AXD AC241_05510 ENOG4108RQ5 Beta-lactamase domain-containing protein AC241_05515 ENOG4105DF9 Lipoate-protein, ligase AC241_05525 ENOG4105CEY Amp-dependent synthetase and ligase AC241_05535 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AC241_05540 ENOG4108I5D sulfate abc transporter AC241_05545 ENOG4105ECW sulfate abc transporter AC241_05550 ENOG4108IJ6 ABC transporter AC241_05635 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) AC241_05645 ENOG4107RN3 metallophosphoesterase AC241_05655 ENOG4107TVP HD domain protein AC241_05670 ENOG4108AEY RNA polymerase sigma factor AC241_05675 ENOG41086D8 Transcriptional regulator AC241_05690 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC241_05710 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AC241_05715 ENOG4105C8Q Methyl-accepting chemotaxis AC241_05720 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AC241_05730 ENOG4107QP3 malate synthase g AC241_05750 ENOG4105VEQ Cold shock protein AC241_05760 ENOG4105XVF Competence transcription factor AC241_05785 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AC241_05830 ENOG4105ERH Fumarylacetoacetate hydrolase AC241_05840 ENOG4105C8Y Acetylornithine aminotransferase AC241_05855 ENOG4105CAQ asparagine synthetase AC241_05860 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AC241_05865 ENOG4105CH6 catalase AC241_05870 ENOG4105BZU Histidine kinase AC241_05890 ENOG4105QNR S1 RNA binding domain protein AC241_05905 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AC241_05915 ENOG4107AYK membrAne AC241_05920 ENOG41073B9 AC241_05930 ENOG4108KP7 hydrolase AC241_05945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AC241_05970 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AC241_05975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AC241_05990 ENOG4105C31 Tryptophanyl-tRNA synthetase AC241_06005 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AC241_06010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AC241_06020 ENOG4108JQ7 (ABC) transporter AC241_06025 ENOG4105UQX Mate efflux family protein AC241_06035 ENOG4105DQ6 Transposase AC241_06060 ENOG4108ZCF integral membrane protein AC241_06070 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AC241_06080 ENOG4105DPN Oligoendopeptidase f AC241_06095 ENOG4108Z18 K06886 hemoglobin AC241_06100 ENOG4105MIX Adenylate cyclase AC241_06105 ENOG4106EFP UPF0738 protein AC241_06115 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AC241_06120 ENOG4105EMS pseudouridine synthase AC241_06140 ENOG4105K64 Glycosyl transferase, family 2 AC241_06160 ENOG4107TVC Glycosyl transferase, family 2 AC241_06180 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AC241_06185 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AC241_06195 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AC241_06280 ENOG4105CK7 Sodium proline symporter AC241_06290 ENOG4105CRQ synthase (Component I) AC241_06295 ENOG4105DDQ anthranilate synthase AC241_06320 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AC241_06335 ENOG4105D7V transposase AC241_06380 ENOG41089UC methyltransferase, type 11 AC241_06400 ENOG4105C7S Dehydrogenase AC241_06405 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AC241_06410 ENOG4105VZ8 Transcriptional regulator AC241_06445 ENOG4108IUX (ABC) transporter AC241_06450 ENOG4105RHA ABC transporter, permease AC241_06470 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AC241_06480 ENOG4105DZ1 carboxypeptidase AC241_06485 ENOG4105VFR signal peptidase AC241_06520 ENOG4105C26 Dehydrogenase AC241_06525 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AC241_06530 ENOG4105F38 ABC transporter, permease AC241_06535 ENOG4105D38 putrescine abc transporter AC241_06540 ENOG4107RUE extracellular solute-binding protein family 1 AC241_06550 ENOG4105EYF MMPL domain protein AC241_06560 ENOG4108YBP pseudouridine synthase AC241_06570 ENOG4105K4I Scp-like extracellular AC241_06575 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AC241_06580 ENOG4105CQB FAD linked oxidase domain protein AC241_06595 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_06600 ENOG4105BZU Histidine kinase AC241_06605 ENOG4105JXH GntR family transcriptional regulator AC241_06625 ENOG4106A3R peptidase AC241_06635 ENOG4108QTI )-transporter AC241_06640 ENOG4107TS3 membrane protein, TerC AC241_06645 ENOG4105CZN Potassium uptake protein AC241_06650 ENOG410681C small acid-soluble spore protein AC241_06655 ENOG4108Z7G MaoC domain protein dehydratase AC241_06675 ENOG4105CHR reductase AC241_06705 ENOG4105C4Y ABC transporter AC241_06710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AC241_06715 ENOG4107RCV ABC transporter, permease AC241_06735 ENOG4105E98 transcriptional regulator DeoR family AC241_06750 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AC241_06760 ENOG4105PXI polysaccharide deacetylase AC241_06770 ENOG4105BZU Histidine kinase AC241_06775 ENOG41090MY MarR family Transcriptional regulator AC241_06785 ENOG4106DF1 AC241_06795 ENOG4105BZU Histidine kinase AC241_06800 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AC241_06805 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AC241_06810 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AC241_06860 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AC241_06865 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AC241_06870 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AC241_06875 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AC241_06880 ENOG4105CZV ABC transporter AC241_06890 ENOG4105CJ1 ABC, transporter AC241_06930 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AC241_06935 ENOG4105EA8 2-Nitropropane dioxygenase AC241_06940 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AC241_06950 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AC241_06975 ENOG4105NQC Flavodoxin AC241_07045 ENOG4105CZN Potassium uptake protein AC241_07050 ENOG41063Y9 AC241_07055 ENOG4105KBJ sporulation protein ytfj AC241_07085 ENOG4105CM2 brancheD-chain amino acid aminotransferase AC241_07090 ENOG4105C7K acetolactate synthase AC241_07095 ENOG4108ZP8 Acetolactate synthase small subunit AC241_07100 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AC241_07115 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AC241_07130 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AC241_07135 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AC241_07170 ENOG4107RVV histidinol phosphate phosphatase, hisj family AC241_07185 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AC241_07190 ENOG4105E0M Sulfatase AC241_07195 ENOG4105VTR Integrase AC241_07210 ENOG4108IMY Transcriptional regulator AC241_07220 ENOG4108ZUE Phage regulatory protein rha AC241_07245 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AC241_07255 ENOG4105KRN Transcriptional regulator, abrb family AC241_07465 ENOG4105XSJ toxin secretion phage lysis holin AC241_07470 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AC241_07500 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AC241_07520 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AC241_07525 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AC241_07535 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AC241_07540 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AC241_07545 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AC241_07555 ENOG4105C8J )-transporter AC241_07575 ENOG4105DFD Na H antiporter AC241_07595 ENOG4105ENE Histidine kinase AC241_07600 ENOG4105WH1 Two component transcriptional regulator luxr family AC241_07620 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AC241_07645 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AC241_07670 ENOG4105CJ3 phosphate transporter AC241_07675 ENOG4107GRR phosphate transport regulator AC241_07680 ENOG4105BZ4 penicillin-binding protein AC241_07695 ENOG4105BZU Histidine kinase AC241_07700 ENOG4105I3N Conserved Protein AC241_07715 ENOG4105BZU Histidine kinase AC241_07750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AC241_07755 ENOG4105DZ1 carboxypeptidase AC241_07760 ENOG4108JIC nucleoside recognition domain protein AC241_07770 ENOG4105FE9 pseudouridine synthase AC241_07775 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AC241_07780 ENOG4107TWT Cytochrome c biogenesis protein AC241_07785 ENOG4105CRE cytochrome C AC241_07790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_07795 ENOG4105BZU Histidine kinase AC241_07800 ENOG4108WBT adenosyltransferase AC241_07815 ENOG4108SAX Membrane AC241_07830 ENOG4105C9U ATP-dependent DNA helicase RecQ AC241_07835 ENOG4105I7S Abortive infection protein AC241_07845 ENOG4107RGJ metallophosphoesterase AC241_07850 ENOG4108XDN Transcriptional regulator AC241_07855 ENOG4108S6Z Negative regulator of genetic competence AC241_07880 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AC241_07885 ENOG4107RB3 L-asparaginase AC241_07905 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AC241_07920 ENOG4105S2F AC241_07925 ENOG41065D1 AC241_07955 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AC241_07970 ENOG4105XXQ heptaprenyl diphosphate synthase component I AC241_07980 ENOG4105EAH synthase AC241_07985 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AC241_07990 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AC241_08005 ENOG41068YB TPR repeat-containing protein AC241_08020 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AC241_08025 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AC241_08035 ENOG4105DQ6 Transposase AC241_08070 ENOG4108JYZ YitT family AC241_08075 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AC241_08090 ENOG4105FJR Lmbe family AC241_08095 ENOG4105CPK Glycosyl transferase (Group 1 AC241_08120 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AC241_08135 ENOG4105DVT helicase AC241_08140 ENOG4105YAC AC241_08160 ENOG4105CSM endonuclease III AC241_08170 ENOG4105BZ4 penicillin-binding protein AC241_08210 ENOG4106F55 Protein of unknown function (DUF1273) AC241_08220 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AC241_08230 ENOG4105DVT helicase AC241_08235 ENOG4105CTD carboxy-peptidase AC241_08245 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AC241_08250 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AC241_08255 ENOG4105C2W permease AC241_08260 ENOG4105DHF Membrane AC241_08265 ENOG410890F Dynamin family AC241_08275 ENOG4108W0I acetyltransferase AC241_08285 ENOG4105KHC sulfurtransferase AC241_08300 ENOG4106032 Glutathionylspermidine synthase AC241_08360 ENOG4105CPK Glycosyl transferase (Group 1 AC241_08395 ENOG41081VK Ribonuclease AC241_08460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AC241_08470 ENOG4107RWR Sodium hydrogen exchanger AC241_08475 ENOG4108Z5V transcriptional regulator, merr family AC241_08485 ENOG4105H67 Protein of unknown function (DUF421) AC241_08490 ENOG41080C8 DUF218 domain AC241_08550 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AC241_08560 ENOG4107R0U MotA TolQ exbB proton channel AC241_08565 ENOG4105ER2 Ompa motb domain protein AC241_08570 ENOG4107YTP response regulator receiver protein AC241_08575 ENOG4105CBS Chea signal transduction histidine kinase AC241_08580 ENOG4105DD5 Flagellar motor switch protein AC241_08595 ENOG4105BZU Histidine kinase AC241_08615 ENOG4105E1Q flagellar hook-associated protein AC241_08620 ENOG4105DTJ flagellar hook-associated protein AC241_08625 ENOG4107TPX flagellar hook-associated AC241_08640 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AC241_08645 ENOG4108ZC9 flagellar basal-body rod protein flgc AC241_08650 ENOG41075Z6 flagellar hook-basal body complex protein fliE AC241_08655 ENOG4107U2N Flagellar M-ring protein AC241_08660 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AC241_08690 ENOG4105BZE flagellar hook protein, FlgE AC241_08705 ENOG4107R88 Chemotaxis protein (CheV) AC241_08720 ENOG4105I03 Flagellin AC241_08725 ENOG4105I03 Flagellin AC241_08730 ENOG4105I03 Flagellin AC241_08735 ENOG4105I03 Flagellin AC241_08740 ENOG4105E4C Lytic transglycosylase catalytic AC241_08750 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AC241_08755 ENOG4105DD5 Flagellar motor switch protein AC241_08765 ENOG4105CN7 Flagellar biosynthetic protein FliP AC241_08770 ENOG4105VS8 Flagellar biosynthetic protein fliq AC241_08780 ENOG4105D00 flagellar biosynthetic protein flhB AC241_08785 ENOG4105D7B Flagellar biosynthesis protein flha AC241_08790 ENOG4105FZW flagellar biosynthesis regulator FlhF AC241_08795 ENOG4105KTQ flagellar basal-body rod protein AC241_08800 ENOG4105CPU Monooxygenase AC241_08840 ENOG4105KAC Antibiotic biosynthesis monooxygenase AC241_08845 ENOG4107QZ7 Cellulose synthase catalytic subunit AC241_08870 ENOG4105DUM transcriptional regulator, lysR family AC241_08875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AC241_08885 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AC241_08920 ENOG4105DQ6 Transposase AC241_08930 ENOG4105CVJ phosphoglycerate mutase AC241_08940 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AC241_08960 ENOG4105CAQ asparagine synthetase AC241_08980 ENOG4105PGM cation diffusion facilitator family transporter AC241_08990 ENOG4105DRR Transcriptional regulator, GntR family AC241_08995 ENOG4108UZ3 Transporter AC241_09005 ENOG4105CKI cobalamin synthesis protein AC241_09010 ENOG4108PJD permease AC241_09025 ENOG4105DFD Na H antiporter AC241_09030 ENOG4105VUF Transcriptional regulator AC241_09040 ENOG4105C9Q fumarate hydratase class II AC241_09060 ENOG4107QJQ Mate efflux family protein AC241_09065 ENOG4105EC3 peptidase S51, dipeptidase E AC241_09085 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AC241_09095 ENOG4107JM4 Tetratricopeptide repeat AC241_09110 ENOG4106BRA Membrane AC241_09145 ENOG4105CJ1 ABC, transporter AC241_09170 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AC241_09180 ENOG4108IJ0 Aspartate ammonia-lyase AC241_09185 ENOG4105C6K Malic enzyme AC241_09250 ENOG4105FVX AC241_09265 ENOG4105CSR polyphosphate kinase 2 AC241_09270 ENOG4105U3E Transcriptional regulator AC241_09285 ENOG4105DXI Major Facilitator superfamily AC241_09300 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AC241_09305 ENOG4105EU0 Major facilitator Superfamily AC241_09310 ENOG4105C6T cysteine synthase AC241_09330 ENOG4105C8J )-transporter AC241_09340 ENOG4105X5K response regulator receiver protein AC241_09345 ENOG4105H67 Protein of unknown function (DUF421) AC241_09365 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AC241_09370 ENOG4105CHR reductase AC241_09375 ENOG4105CM2 brancheD-chain amino acid aminotransferase AC241_09380 ENOG4105C7K acetolactate synthase AC241_09390 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AC241_09395 ENOG4105C01 Dihydroxy-acid dehydratase AC241_09400 ENOG4105C7B Threonine dehydratase AC241_09425 ENOG4105C6X Major Facilitator AC241_09430 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AC241_09440 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AC241_09445 ENOG4105DY9 regulatoR AC241_09450 ENOG4105CYC Transferase AC241_09455 ENOG4105K5X acetyltransferase AC241_09465 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) AC241_09470 ENOG4105EQ0 Major Facilitator superfamily AC241_09475 ENOG4108IND Tetr family transcriptional regulator AC241_09485 ENOG41068WN AC241_09510 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AC241_09525 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AC241_09535 ENOG4105C0X amino acid AC241_09570 ENOG410849A acetyltransferase, (GNAT) family AC241_09575 ENOG4105K8R UPF0145 protein AC241_09580 ENOG4108TYN CAAX amino terminal protease family protein AC241_09590 ENOG4107RHR regulatoR AC241_09600 ENOG4105D9N nucleoside AC241_09605 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AC241_09625 ENOG4107RAQ aminopeptidase AC241_09635 ENOG4107R16 Multicopper oxidase AC241_09675 ENOG4108T5E Copper resistance protein AC241_09680 ENOG4105KTB nuclear export factor GLE1 AC241_09685 ENOG4107RT3 EamA-like transporter family AC241_09690 ENOG4105GZI Transcriptional regulator AC241_09695 ENOG4108Z40 Transcriptional regulator AC241_09700 ENOG4107ZXU DSBA oxidoreductase AC241_09705 ENOG4108TVJ Nitroreductase AC241_09715 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AC241_09720 ENOG4106F5Q Membrane AC241_09725 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AC241_09735 ENOG4105CKI cobalamin synthesis protein AC241_09745 ENOG4105C0Z ABC transporter AC241_09750 ENOG4108IV0 ABC, transporter AC241_09755 ENOG4105C32 Amino acid ABC transporter (Permease) AC241_09765 ENOG4105SKE transcriptional Regulator LysR family AC241_09775 ENOG4105MDS 4-oxalocrotonate tautomerase AC241_09795 ENOG4105C4M (Ubiquinol oxidase) subunit I AC241_09800 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AC241_09805 ENOG4108JJ9 ABC, transporter AC241_09810 ENOG4108JJ8 (ABC) transporter AC241_09820 ENOG4105K64 Glycosyl transferase, family 2 AC241_09830 ENOG4108UT6 Transferase hexapeptide repeat containing protein AC241_09885 ENOG4105BZ1 (ABC) transporter AC241_09890 ENOG4105EFI regulatoR AC241_09895 ENOG4105BZU Histidine kinase AC241_09920 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AC241_09925 ENOG4108ZJ4 polysaccharide deacetylase AC241_09945 ENOG4105D6E homoserine dehydrogenase AC241_09970 ENOG4108KGH TRANSCRIPTIONal AC241_09975 ENOG4107VMI polysaccharide deacetylase AC241_09985 ENOG4105KT7 mgtC SapB transporter AC241_09995 ENOG4105DQ6 Transposase AC241_10000 ENOG4105VRR gCN5-related N-acetyltransferase AC241_10010 ENOG4105DUU IucA IucC family protein AC241_10015 ENOG4105CEY Amp-dependent synthetase and ligase AC241_10030 ENOG4108WBH protein TIM barrel AC241_10035 ENOG4105YWU small acid-soluble spore protein AC241_10045 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AC241_10050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC241_10100 ENOG4105KRN Transcriptional regulator, abrb family AC241_10110 ENOG4105YVS arsR family transcriptional regulator AC241_10115 ENOG4105CPC Aldo Keto reductase AC241_10120 ENOG4107XZQ multidrug resistance protein AC241_10145 ENOG4105C8Q Methyl-accepting chemotaxis AC241_10165 ENOG4108K88 Membrane AC241_10170 ENOG4108WPJ Ferritin-like domain AC241_10185 ENOG4105DEN Luciferase family AC241_10200 ENOG4105VMI -acetyltransferase AC241_10210 ENOG4105DQ6 Transposase AC241_10215 ENOG4107QM2 Aldo Keto reductase AC241_10225 ENOG4105CKI cobalamin synthesis protein AC241_10235 ENOG4105DSE periplasmic solute binding protein AC241_10245 ENOG4105K4T epimerase AC241_10255 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AC241_10280 ENOG4105CVJ phosphoglycerate mutase AC241_10300 ENOG4107T5V SNARE associated Golgi AC241_10315 ENOG4108PJD permease AC241_10325 ENOG4108S4H thioesterase Superfamily protein AC241_10330 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AC241_10350 ENOG4105SXS Protein of unknown function (DUF456) AC241_10355 ENOG4105C37 (CBS) domain AC241_10365 ENOG4108SGK Tetr family transcriptional regulator AC241_10385 ENOG4108Z7R Chaperone CsaA AC241_10405 ENOG4108ZRV stage ii sporulation protein p AC241_10415 ENOG4108VXD carboxy-peptidase AC241_10445 ENOG4108ZRV stage ii sporulation protein p AC241_10455 ENOG4108X4Q Hydrolase AC241_10460 ENOG41082F9 transcriptional regulator AC241_10465 ENOG4105D94 Major Facilitator Superfamily AC241_10475 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AC241_10480 ENOG4107RBS Methyltransferase AC241_10495 ENOG41087PP glycosyltransferase MGT family AC241_10500 ENOG4108JYZ YitT family AC241_10505 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AC241_10535 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AC241_10560 ENOG4105KBJ sporulation protein ytfj AC241_10585 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AC241_10605 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AC241_10610 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AC241_10620 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AC241_10625 ENOG4105EMN RNA polymerase sigma factor AC241_10640 ENOG4105CNW domain protein AC241_10650 ENOG4108V06 Glutathione peroxidase AC241_10665 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AC241_10675 ENOG4108IUE nitrate reductase beta subunit AC241_10680 ENOG4105R3A Nitrate reductase AC241_10690 ENOG4107V6Q Cyclic nucleotide-binding domain AC241_10695 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AC241_10700 ENOG4105D06 uba thif-type nad fad binding protein AC241_10705 ENOG4105CVM Molybdenum cofactor synthesis domain protein AC241_10710 ENOG4108ZAF Molybdopterin AC241_10735 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AC241_10740 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AC241_10745 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AC241_10750 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AC241_10755 ENOG4108IFG nitrite reductase, (NAD(P)H) AC241_10760 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AC241_10795 ENOG4105MCT stage V sporulation protein S AC241_10810 ENOG4105C5H ABC transporter AC241_10825 ENOG4108UUM single-stranded DNA-binding protein AC241_10855 ENOG4107YX5 Pfam:DUF548 AC241_10860 ENOG4105C75 arginyL-tRNA synthetase AC241_10875 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AC241_10900 ENOG4105C5S asparaginyl-tRNA synthetase AC241_10905 ENOG4105C8J )-transporter AC241_10925 ENOG4107XGZ Hydrolase AC241_10930 ENOG4105CY2 Citrate transporter AC241_10950 ENOG4105KD7 acetyltransferase AC241_10960 ENOG4105VMP Transcriptional regulator AC241_10965 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AC241_11010 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AC241_11025 ENOG4107RVG penicillin-binding protein AC241_11035 ENOG4105E9Q Acyl-transferase AC241_11040 ENOG4108UT2 hemolysin iii AC241_11050 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AC241_11060 ENOG4108RCR degv family AC241_11065 ENOG4107T8T UPF0173 metal-dependent hydrolase AC241_11070 ENOG4108KF3 Electron transport protein SCO1 SenC AC241_11080 ENOG4105CAQ asparagine synthetase AC241_11095 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AC241_11100 ENOG4108MES Periplasmic binding protein AC241_11105 ENOG4105F0I Aminotransferase AC241_11130 ENOG4105E09 nadh pyrophosphatase AC241_11135 ENOG4105D8X mechanosensitive ion channel AC241_11140 ENOG4105BZU Histidine kinase AC241_11145 ENOG4105WH1 Two component transcriptional regulator luxr family AC241_11150 ENOG4106KNT transcriptional regulator AC241_11155 ENOG4107ZY0 Phenazine biosynthesis-like protein AC241_11175 ENOG4105CMG Carbohydrate kinase AC241_11180 ENOG4105C6Z Gluconate AC241_11190 ENOG4108YV3 Protein of unknown function (DUF2711) AC241_11220 ENOG4108IJ8 ABC transporter AC241_11225 ENOG4105E90 ABC transporter AC241_11260 ENOG4105C37 (CBS) domain AC241_11285 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AC241_11300 ENOG4107S4Y M20 DapE family protein YgeY AC241_11305 ENOG4108TSC N-acetyltransferase AC241_11310 ENOG4108JUB Transcriptional regulator AC241_11315 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AC241_11355 ENOG4108N23 SpoOM-related protein AC241_11360 ENOG410841Q phosphoesterase PA-phosphatase related protein AC241_11370 ENOG4105SZ6 Thioredoxin AC241_11415 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AC241_11465 ENOG4105BZ4 penicillin-binding protein AC241_11475 ENOG4105CZM Major Facilitator AC241_11490 ENOG4105DXD 2-methylcitrate dehydratase AC241_11495 ENOG4105CR4 methylisocitrate lyase AC241_11500 ENOG4105C1G acyl-Coa dehydrogenase AC241_11505 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AC241_11515 ENOG4105N14 lysine exporter protein LysE YggA AC241_11520 ENOG4105E39 Enoyl-CoA hydratase AC241_11535 ENOG4107RFY SbcCD D subunit AC241_11540 ENOG4105EYH Exonuclease AC241_11565 ENOG4105FCD Major Facilitator AC241_11570 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AC241_11575 ENOG4105E4F Isochorismate synthase AC241_11580 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AC241_11585 ENOG4105WQI isochorismatase AC241_11590 ENOG4105CEY Amp-dependent synthetase and ligase AC241_11595 ENOG4105WQT MbtH domain protein AC241_11600 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC241_11615 ENOG4105K70 DNA-binding protein AC241_11635 ENOG4105BZG amino acid carrier protein AC241_11655 ENOG4105FE9 pseudouridine synthase AC241_11660 ENOG4105C22 threonyL-tRNA synthetase AC241_11665 ENOG4105C19 ABC transporter AC241_11720 ENOG41081I9 integral membrane protein AC241_11730 ENOG4108Y4K DNA-binding transcriptional activator AC241_11745 ENOG4107MII Sugar-specific transcriptional regulator TrmB AC241_11765 ENOG4105EYF MMPL domain protein AC241_11790 ENOG4105WCN acetyltransferase AC241_11815 ENOG4105C1Q protoporphyrinogen oxidase AC241_11825 ENOG41068WN AC241_11855 ENOG4107V2S Transcriptional regulator AC241_11860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AC241_11880 ENOG4105DND Transcriptional regulator AC241_11885 ENOG4108RPX mosc domain containing protein AC241_11900 ENOG4105BZ1 (ABC) transporter AC241_11905 ENOG4105BZ1 (ABC) transporter AC241_11930 ENOG4108JCI Transcriptional regulator AC241_11970 ENOG4108KPJ rna polymerase sigma factor AC241_11995 ENOG4105F32 YngK protein AC241_12015 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) AC241_12020 ENOG4105RD7 BadF BadG BcrA BcrD AC241_12025 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AC241_12030 ENOG4107STF Involved in phosphonate degradation (By similarity) AC241_12035 ENOG4105C7B Threonine dehydratase AC241_12040 ENOG4108INS Transcriptional regulator AC241_12055 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AC241_12070 ENOG4105C1J atp-dependent rna helicase AC241_12075 ENOG4108RZE Tetr family transcriptional regulator AC241_12110 ENOG4107RA9 decarboxylase AC241_12115 ENOG41090HR transcriptional regulator AC241_12120 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AC241_12145 ENOG4105CIN aminoacyl-histidine dipeptidase AC241_12180 ENOG4105KRN Transcriptional regulator, abrb family AC241_12190 ENOG4105EJ9 Membrane AC241_12195 ENOG4105EQK -acetyltransferase AC241_12235 ENOG4105W8Z 4'-phosphopantetheinyl transferase AC241_12245 ENOG4105CHR reductase AC241_12270 ENOG4107S9D Alpha beta hydrolase AC241_12310 ENOG4107RVG penicillin-binding protein AC241_12325 ENOG4107RF6 penicillin-binding protein AC241_12330 ENOG4107RF6 penicillin-binding protein AC241_12350 ENOG4105DIN metallophosphoesterase AC241_12360 ENOG4105CJ1 ABC, transporter AC241_12370 ENOG4107Z3H Transcriptional regulator, TetR family AC241_12380 ENOG4105C1G acyl-Coa dehydrogenase AC241_12385 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AC241_12390 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AC241_12395 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AC241_12400 ENOG4105E39 Enoyl-CoA hydratase AC241_12405 ENOG4107QX3 carboxylase AC241_12410 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AC241_12420 ENOG4105DQ6 Transposase AC241_12450 ENOG4105DBI uridine monophosphokinase AC241_12465 ENOG4105DZ1 carboxypeptidase AC241_12480 ENOG4105T9C HD domain AC241_12495 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AC241_12520 ENOG41075H3 AraC family transcriptional regulator AC241_12550 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AC241_12575 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AC241_12580 ENOG4105KVH Transcriptional regulator AC241_12585 ENOG41089UC methyltransferase, type 11 AC241_12595 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AC241_12610 ENOG4105CJ1 ABC, transporter AC241_12655 ENOG4105CPQ Dehydrogenase AC241_12665 ENOG410900G Protein of unknown function (DUF421) AC241_12675 ENOG4108V4B ThiJ pfpI AC241_12685 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AC241_12695 ENOG4105DK7 lysyl-tRNA synthetase AC241_12720 ENOG4106NZI LysR family Transcriptional regulator AC241_12725 ENOG4105CPC Aldo Keto reductase AC241_12775 ENOG4105D6E homoserine dehydrogenase AC241_12785 ENOG4105CPF Cell wall formation (By similarity) AC241_12790 ENOG4105ETU transcriptional activator (TenA AC241_12815 ENOG4105VTR Integrase AC241_12865 ENOG4105KRN Transcriptional regulator, abrb family AC241_12990 ENOG4105CAR Terminase, large subunit AC241_13000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AC241_13070 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis AC241_13165 ENOG410667J hydrolase AC241_13170 ENOG4105BZU Histidine kinase AC241_13175 ENOG4107RF6 penicillin-binding protein AC241_13200 ENOG4108JJB ABC transporter AC241_13210 ENOG4108HGU Histidine kinase AC241_13270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_13275 ENOG4105GR3 Histidine kinase AC241_13280 ENOG4105CB2 alcohol dehydrogenase AC241_13285 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AC241_13290 ENOG4105CJN penicillin-binding protein AC241_13335 ENOG4107Y80 Major Facilitator superfamily AC241_13340 ENOG4108Z5V transcriptional regulator, merr family AC241_13360 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AC241_13385 ENOG4107Y9U Membrane AC241_13425 ENOG4105FCD Major Facilitator AC241_13440 ENOG4105E09 nadh pyrophosphatase AC241_13445 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AC241_13470 ENOG4105KME endoribonuclease L-psp AC241_13475 ENOG4108XI2 Domain of unknown function (DUF1963) AC241_13505 ENOG4105KWG Pfam:DUF1696 AC241_13540 ENOG4105PKS Excinuclease abc c subunit domain protein AC241_13580 ENOG4107VFR oxidoreductase AC241_13610 ENOG4105U0R haloacid dehalogenase-like hydrolase AC241_13615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_13620 ENOG4105BZU Histidine kinase AC241_13640 ENOG4107WD8 ABC transporter, permease AC241_13655 ENOG4108IUM Glycogen debranching enzyme AC241_13665 ENOG4105CGH 5'-nucleotidase AC241_13680 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AC241_13690 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) AC241_13695 ENOG4105FDR Membrane AC241_13705 ENOG4105CIS alcohol dehydrogenase AC241_13710 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AC241_13755 ENOG4105MSI germination protein ypeb AC241_13785 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AC241_13790 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AC241_13795 ENOG4107Z3H Transcriptional regulator, TetR family AC241_13825 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AC241_13845 ENOG4105E98 transcriptional regulator DeoR family AC241_13860 ENOG41062ES Transcriptional regulator AC241_13880 ENOG4107QKR Dehydrogenase AC241_13890 ENOG4107RUY (E1 component), alpha subunit AC241_13910 ENOG4105E1F short-chain dehydrogenase reductase AC241_13915 ENOG4105RHY Pfam:UPF0157 AC241_13925 ENOG4105E09 nadh pyrophosphatase AC241_13950 ENOG4107SQ8 Glycine betaine AC241_13955 ENOG4108IJ7 Glycine betaine AC241_13980 ENOG4105E66 phosphoriboisomerase A AC241_13985 ENOG41082BV acetyltransferase AC241_13990 ENOG4108M1A Chitin-binding protein AC241_14015 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AC241_14020 ENOG4105MSB protein, conserved in bacteria AC241_14070 ENOG4105EEM helicase AC241_14090 ENOG4105C9U ATP-dependent DNA helicase RecQ AC241_14120 ENOG4105DQ6 Transposase AC241_14155 ENOG4108M1A Chitin-binding protein AC241_14180 ENOG4105BZG amino acid carrier protein AC241_14185 ENOG4105C26 Dehydrogenase AC241_14190 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AC241_14195 ENOG4105CTU Proline racemase AC241_14200 ENOG4105CTU Proline racemase AC241_14205 ENOG41080HI glycine oxidase AC241_14215 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AC241_14250 ENOG4105DCI Phosphohydrolase AC241_14255 ENOG4107T5V SNARE associated Golgi AC241_14265 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AC241_14280 ENOG4105DTQ mandelate racemase muconate lactonizing AC241_14295 ENOG4107SET aldo keto reductase AC241_14325 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AC241_14330 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AC241_14335 ENOG4105BZU Histidine kinase AC241_14340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_14360 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 AC241_14380 ENOG4105DPN Oligoendopeptidase f AC241_14385 ENOG4105EPR degv family AC241_14400 ENOG4105CHJ isochorismatase hydrolase AC241_14440 ENOG4106K7D Major facilitator family transporter AC241_14465 ENOG4107BMA Transglycosylase associated protein AC241_14480 ENOG41089UC methyltransferase, type 11 AC241_14515 ENOG4105CHM Aminotransferase AC241_14530 ENOG4108ZMI UPF0477 protein AC241_14545 ENOG4105DVE abc transporter atp-binding protein AC241_14600 ENOG4105C02 permease AC241_14615 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AC241_14620 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AC241_14625 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AC241_14630 ENOG4105D7T ABC transporter AC241_14665 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AC241_14700 ENOG4107VC0 DNA alkylation repair enzyme AC241_14705 ENOG4105C6T cysteine synthase AC241_14710 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AC241_14725 ENOG4107VMI polysaccharide deacetylase AC241_14730 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC AC241_14740 ENOG4106ETB IIa component AC241_14745 ENOG4108ZCF integral membrane protein AC241_14750 ENOG4105E0M Sulfatase AC241_14755 ENOG4105C5H ABC transporter AC241_14760 ENOG4105EYF MMPL domain protein AC241_14765 ENOG41082JN Transcriptional regulator AC241_14790 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AC241_14795 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AC241_14840 ENOG41069ER domain protein AC241_14850 ENOG4105DNP FAD linked oxidase domain protein AC241_14860 ENOG41082JN Transcriptional regulator AC241_14870 ENOG4105JVQ RNA Polymerase AC241_14895 ENOG4105D4B ABC, transporter AC241_14900 ENOG4105F5R ABC transporter AC241_14905 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AC241_14915 ENOG4105DKT Transcriptional regulator AC241_14920 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AC241_14930 ENOG41061GT Aldolase AC241_14945 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AC241_14975 ENOG4105II7 pyrroline-5-carboxylate reductase AC241_14985 ENOG4107258 Transcriptional regulator AC241_15010 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AC241_15020 ENOG4105ECK Fatty Acid Desaturase AC241_15030 ENOG4107RBI VanW family AC241_15035 ENOG4105G6Z alkaline phosphatase AC241_15045 ENOG4105VMP Transcriptional regulator AC241_15070 ENOG41068WN AC241_15095 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AC241_15115 ENOG4105C8Y Acetylornithine aminotransferase AC241_15135 ENOG4106P55 Transcriptional regulator AC241_15160 ENOG4108TVJ Nitroreductase AC241_15165 ENOG4105FS7 Transcriptional regulator AC241_15180 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AC241_15185 ENOG4105WEC Molybdate metabolism regulator AC241_15190 ENOG4105CMR udp-glucose 4-epimerase AC241_15195 ENOG4105C19 ABC transporter AC241_15220 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF AC241_15225 ENOG4108XET gCN5-related N-acetyltransferase AC241_15240 ENOG4108PCN EamA-like transporter family AC241_15265 ENOG4105RHY Pfam:UPF0157 AC241_15285 ENOG410635A Membrane AC241_15295 ENOG4108IQI permease AC241_15305 ENOG4105F1N DNA alkylation repair AC241_15340 ENOG4107RF6 penicillin-binding protein AC241_15345 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AC241_15375 ENOG4105P4J Allophanate hydrolase, subunit 1 AC241_15380 ENOG4107258 Transcriptional regulator AC241_15395 ENOG4106N3A copper homeostasis protein cutc AC241_15400 ENOG4108ZHR arsR family transcriptional regulator AC241_15410 ENOG4105FDT acyl-CoA dehydrogenase AC241_15425 ENOG4105DWD nucleoside recognition domain protein AC241_15470 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AC241_15480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AC241_15490 ENOG4105CGH 5'-nucleotidase AC241_15500 ENOG4105CHJ isochorismatase hydrolase AC241_15530 ENOG4105F6J Alpha beta hydrolase fold AC241_15545 ENOG4107VMI polysaccharide deacetylase AC241_15550 ENOG4105KY5 gCN5-related N-acetyltransferase AC241_15555 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AC241_15560 ENOG4105DSE periplasmic solute binding protein AC241_15565 ENOG4105CC5 ABC transporter AC241_15570 ENOG4105DIK (ABC) transporter AC241_15595 ENOG4105D6J arsenicaL-resistance protein AC241_15600 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AC241_15605 ENOG41085FC arsR family transcriptional regulator AC241_15610 ENOG4105CHR reductase AC241_15615 ENOG4108YXU transcriptional regulator AsnC family AC241_15670 ENOG4105C44 Serine transporter AC241_15675 ENOG4105DUM transcriptional regulator, lysR family AC241_15680 ENOG4105DWP Membrane AC241_15685 ENOG4105N0V mono-oxygenase ydhR AC241_15730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_15735 ENOG41062D9 Histidine kinase AC241_15775 ENOG4105C19 ABC transporter AC241_15820 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AC241_15825 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC241_15850 ENOG4105K6H D-cysteine desulfhydrase AC241_15860 ENOG4105E0Y RtcB Protein AC241_15885 ENOG4105DNP FAD linked oxidase domain protein AC241_15895 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AC241_15915 ENOG4105BZU Histidine kinase AC241_15920 ENOG4105EFI regulatoR AC241_15925 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AC241_15945 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AC241_15965 ENOG4108JQ1 Dehydrogenase AC241_15970 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AC241_15985 ENOG41082W1 Cupin 2, conserved barrel domain protein AC241_15990 ENOG410874W AraC family transcriptional regulator AC241_16005 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AC241_16025 ENOG4108VXD carboxy-peptidase AC241_16030 ENOG4105PNM synthesis protein AC241_16040 ENOG4108ISG Major Facilitator AC241_16055 ENOG4107MII Sugar-specific transcriptional regulator TrmB AC241_16060 ENOG4105CZM Major Facilitator AC241_16075 ENOG4105CRW Short chain fatty acid transporter AC241_16085 ENOG4105DYS nad(p)h dehydrogenase (quinone) AC241_16145 ENOG4108K8S endonuclease I AC241_16155 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AC241_16165 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC241_16175 ENOG4108Z66 YbaK ebsC protein AC241_16185 ENOG4105KVH Transcriptional regulator AC241_16190 ENOG4108RCM Nitroreductase AC241_16200 ENOG4105CA9 Pyruvate kinase AC241_16220 ENOG4108PSK reductase AC241_16285 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AC241_16290 ENOG4105DKQ ROK family AC241_16295 ENOG4106UW1 Major Facilitator superfamily AC241_16300 ENOG4108UW5 maltose o-acetyltransferase AC241_16305 ENOG4105C31 Tryptophanyl-tRNA synthetase AC241_16310 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AC241_16340 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AC241_16350 ENOG4105EV4 Multidrug resistance protein mdtH AC241_16375 ENOG4105C37 (CBS) domain AC241_16390 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AC241_16395 ENOG4105FAW cDP-glucose 4,6-dehydratase AC241_16425 ENOG4105DDN Pentapeptide repeat-containing protein AC241_16430 ENOG4105XDF Protein of unknown function (DUF1272) AC241_16435 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AC241_16440 ENOG4105CMG Carbohydrate kinase AC241_16445 ENOG4105C6Z Gluconate AC241_16460 ENOG4105CV1 Transketolase (EC 2.2.1.1) AC241_16465 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AC241_16470 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AC241_16480 ENOG4105CIS alcohol dehydrogenase AC241_16485 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone AC241_16500 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AC241_16515 ENOG4105C8Q Methyl-accepting chemotaxis AC241_16520 ENOG4108UX3 '-nucleotidase AC241_16525 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AC241_16530 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AC241_16535 ENOG4105KVH Transcriptional regulator AC241_16555 ENOG41090KN UPF0303 protein AC241_16565 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AC241_16570 ENOG4105CHH sulfate transporter AC241_16585 ENOG4105C44 Serine transporter AC241_16615 ENOG4105KVH Transcriptional regulator AC241_16620 ENOG4108TZY GntR Family Transcriptional Regulator AC241_16625 ENOG4105D9R oxidoreductase AC241_16630 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AC241_16635 ENOG4105KVH Transcriptional regulator AC241_16640 ENOG4105KVH Transcriptional regulator AC241_16690 ENOG4105JAB phenazine biosynthesis protein, phzf family AC241_16715 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AC241_16720 ENOG4105KVH Transcriptional regulator AC241_16735 ENOG4108ZJ4 polysaccharide deacetylase AC241_16810 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AC241_16820 ENOG4107YXZ hydrolase, family 25 AC241_16855 ENOG4105H3G oxidoreductase AC241_16895 ENOG4105CBK multidrug resistance protein AC241_16920 ENOG4108TN2 lmbE family AC241_16930 ENOG4107R3E Citrate transporter AC241_16945 ENOG4108MES Periplasmic binding protein AC241_16950 ENOG4105EHG Permease protein AC241_16955 ENOG4105DQ5 transport system permease protein AC241_16960 ENOG4105NX3 Membrane AC241_16980 ENOG4107CUJ Protein of unknown function (DUF2690) AC241_16990 ENOG4107V2S Transcriptional regulator AC241_17010 ENOG4105C98 muts2 protein AC241_17015 ENOG4105E5K Alpha-amylase AC241_17020 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AC241_17025 ENOG4105DPN Oligoendopeptidase f AC241_17050 ENOG4105FFC UPF0187 protein AC241_17065 ENOG4108A04 Beta-lactamase AC241_17090 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AC241_17100 ENOG4105EEM helicase AC241_17120 ENOG4105DQ6 Transposase AC241_17135 ENOG41082BM Transcriptional regulator, arsr family AC241_17140 ENOG4105CIS alcohol dehydrogenase AC241_17145 ENOG4105CNG UPF0061 protein AC241_17165 ENOG4105RHY Pfam:UPF0157 AC241_17175 ENOG4105C09 Bile acid AC241_17180 ENOG4105CQB FAD linked oxidase domain protein AC241_17205 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AC241_17220 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AC241_17225 ENOG4108M1A Chitin-binding protein AC241_17235 ENOG4105E1K spore germination protein AC241_17275 ENOG4105BZU Histidine kinase AC241_17280 ENOG4105C5H ABC transporter AC241_17285 ENOG41067SE Tetr family transcriptional regulator AC241_17290 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity AC241_17300 ENOG4108VXD carboxy-peptidase AC241_17305 ENOG4107DUR UPF0457 protein AC241_17325 ENOG4105BZU Histidine kinase AC241_17335 ENOG4105KT7 mgtC SapB transporter AC241_17350 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AC241_17355 ENOG4105EAB amino acid AbC transporter AC241_17365 ENOG4108HW4 amino acid AbC transporter AC241_17370 ENOG41073R8 VanW family AC241_17380 ENOG4108R1P AC241_17400 ENOG4105VEQ Cold shock protein AC241_17425 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AC241_17445 ENOG410904N short-chain dehydrogenase reductase AC241_17455 ENOG4106IQC argininosuccinate lyase AC241_17470 ENOG4108IA2 Sodium pantothenate symporter AC241_17480 ENOG4105C26 Dehydrogenase AC241_17485 ENOG4105CHR reductase AC241_17495 ENOG4105EWU Squalene--hopene cyclase AC241_17505 ENOG4105FR1 rard protein AC241_17510 ENOG410696E Membrane AC241_17525 ENOG4105D1F ATP-binding protein AC241_17535 ENOG4108ZAF Molybdopterin AC241_17540 ENOG4105CVM Molybdenum cofactor synthesis domain protein AC241_17545 ENOG4105D06 uba thif-type nad fad binding protein AC241_17550 ENOG4105TMB Formate nitrite transporter AC241_17560 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AC241_17565 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AC241_17575 ENOG4108JB9 formate dehydrogenase AC241_17585 ENOG4105E1K spore germination protein AC241_17600 ENOG4105CUB amino acid AC241_17655 ENOG4108KGH TRANSCRIPTIONal AC241_17665 ENOG4105EMN RNA polymerase sigma factor AC241_17675 ENOG4105CIG ABC transporter AC241_17685 ENOG4105D9R oxidoreductase AC241_17695 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AC241_17705 ENOG4105K4P CoA-binding domain protein AC241_17710 ENOG4105C0H protease AC241_17715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_17725 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AC241_17730 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AC241_17735 ENOG4105W8X HesB YadR YfhF-family protein AC241_17760 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AC241_17765 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AC241_17775 ENOG4108JJA ABC, transporter AC241_17780 ENOG4108I0Z Aconitate hydratase AC241_17810 ENOG4105E5W Transporter AC241_17820 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AC241_17850 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AC241_17855 ENOG4108FPN Integrase AC241_17865 ENOG4107F3J Amp-dependent synthetase and ligase AC241_17870 ENOG4107ZYJ bioY protein AC241_17875 ENOG4105CEY Amp-dependent synthetase and ligase AC241_17880 ENOG4108IMY Transcriptional regulator AC241_17900 ENOG4105D9G High-affinity AC241_17905 ENOG4105IW1 AmiS UreI transporter AC241_17920 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AC241_17960 ENOG4107AYK membrAne AC241_17970 ENOG4105BZU Histidine kinase AC241_17975 ENOG4105FBA Phospholipase Carboxylesterase AC241_17980 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AC241_17985 ENOG4105CK7 Sodium proline symporter AC241_17995 ENOG4105CBC glutamate synthase AC241_18000 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC241_18005 ENOG4108VJ1 Transcriptional regulator (CarD family AC241_18010 ENOG4108903 Formimidoylglutamase AC241_18035 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AC241_18070 ENOG4107QIV Cytochrome c biogenesis protein AC241_18080 ENOG4105CH2 amidohydrolase AC241_18090 ENOG4105CJ1 ABC, transporter AC241_18105 ENOG4107RSM transcriptional regulator AC241_18110 ENOG4105VAW lrga family AC241_18115 ENOG41067MG lrgb family AC241_18155 ENOG4105BZ1 (ABC) transporter AC241_18160 ENOG4105BZ1 (ABC) transporter AC241_18195 ENOG4108HW3 (ABC) transporter AC241_18200 ENOG4105CGH 5'-nucleotidase AC241_18210 ENOG4108SVB resolvase AC241_18230 ENOG4105K7K Transcriptional regulator AC241_18250 ENOG4105C5F glutamine synthetase AC241_18255 ENOG4105KV4 Transcriptional regulator AC241_18260 ENOG4105CXI aluminum resistance protein AC241_18265 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AC241_18270 ENOG4105EN6 Membrane AC241_18280 ENOG4106F1P AAA ATPase, central domain protein AC241_18295 ENOG4105DQ6 Transposase AC241_18320 ENOG41069ER domain protein AC241_18325 ENOG4105DM4 PTS System AC241_18330 ENOG4105DE4 1-phosphofructokinase AC241_18335 ENOG4105E98 transcriptional regulator DeoR family AC241_18340 ENOG4107QW4 alcohol dehydrogenase AC241_18345 ENOG4108SJC Membrane AC241_18360 ENOG4105C85 amino acid AC241_18380 ENOG4105TMB Formate nitrite transporter AC241_18385 ENOG4105K70 DNA-binding protein AC241_18395 ENOG4105C59 p-type ATPase AC241_18400 ENOG410681U heavy metal transport detoxification protein AC241_18405 ENOG4105VPX protein, conserved in bacteria AC241_18425 ENOG4105NIV Esterase AC241_18430 ENOG4105E0A ABC, transporter AC241_18450 ENOG4105CGK Exodeoxyribonuclease III AC241_18460 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AC241_18465 ENOG4105D03 DNA-3-methyladenine glycosylase II AC241_18495 ENOG4105BZU Histidine kinase AC241_18515 ENOG4105C5E polysaccharide biosynthesis protein AC241_18535 ENOG41067MG lrgb family AC241_18555 ENOG4108S3Y transcriptional regulator AC241_18560 ENOG4105CS2 ec 3.2.1.21 AC241_18575 ENOG4105F0V Cell wall hydrolase AC241_18585 ENOG4105E0M Sulfatase AC241_18590 ENOG410890F Dynamin family AC241_18625 ENOG4105DQU oxidoreductase, subunit beta AC241_18630 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AC241_18635 ENOG4108IGT Dipeptidase AC241_18640 ENOG4105MCT stage V sporulation protein S AC241_18645 ENOG4105D48 metallophosphoesterase AC241_18670 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AC241_18685 ENOG4105XZV Protein of unknown function (DUF3243) AC241_18690 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AC241_18710 ENOG4105UIB (ABC) transporter AC241_18715 ENOG4108JQ9 ABC transporter AC241_18720 ENOG4105DIH basic membrane AC241_18725 ENOG4105FDP GntR family transcriptional regulator AC241_18730 ENOG4105CNU cell division protein FtsK AC241_18740 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AC241_18750 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AC241_18760 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AC241_18765 ENOG4108S0H Dipicolinic acid synthetase, b subunit AC241_18770 ENOG4105E35 Dipicolinate synthase subunit A AC241_18780 ENOG4105C1V Peptidase, M16 AC241_18800 ENOG4105DTN riboflavin biosynthesis protein ribF AC241_18815 ENOG4105W7A Protein of unknown function (DUF503) AC241_18825 ENOG4105VHM ribosomal protein AC241_18830 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AC241_18835 ENOG4105CHV Transcription elongation factor NusA AC241_18845 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AC241_18855 ENOG4105DZP Membrane-associated zinc metalloprotease AC241_18860 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AC241_18865 ENOG4105KNE Phosphatidate cytidylyltransferase AC241_18870 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AC241_18880 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AC241_18910 ENOG4108HE4 integrase family AC241_18920 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AC241_18925 ENOG4105C79 DNA protecting protein DprA AC241_18930 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AC241_18945 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AC241_18970 ENOG4105VB6 UPF0109 protein AC241_18990 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AC241_18995 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AC241_19010 ENOG4105CHR reductase AC241_19015 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AC241_19030 ENOG4105CB5 ATP-dependent DNA helicase recG AC241_19035 ENOG4105DP4 dak2 domain fusion protein ylov AC241_19040 ENOG4108ZAA Alkaline-shock protein AC241_19055 ENOG4105FJ0 thiamine AC241_19060 ENOG4105DJV ribulose-phosphate 3-epimerase AC241_19065 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AC241_19070 ENOG4105D9P serine threonine protein kinase AC241_19075 ENOG4108ZF3 Phosphatase AC241_19085 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AC241_19100 ENOG4105C25 Primosomal protein n' AC241_19105 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AC241_19125 ENOG4105DSJ YicC domain protein AC241_19135 ENOG4105F23 Fibronectin-binding protein AC241_19145 ENOG4105DC7 peptidase M24 AC241_19195 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AC241_19230 ENOG4105C34 Pseudouridine synthase AC241_19245 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AC241_19255 ENOG4105DBK s4 domain protein AC241_19260 ENOG41067XK integral membrane protein AC241_19270 ENOG4105DFA alanine racemase domain protein AC241_19275 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AC241_19280 ENOG4105WR5 sporulation protein, YlmC YmxH family AC241_19290 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_19300 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AC241_19305 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AC241_19315 ENOG4105D4A Cell wall formation (By similarity) AC241_19320 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AC241_19325 ENOG4105CNI cell division protein FtsW AC241_19340 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AC241_19345 ENOG4105CJN penicillin-binding protein AC241_19350 ENOG4105CJN penicillin-binding protein AC241_19365 ENOG41074B2 UPF0747 protein AC241_19390 ENOG4105KNH Nucleic acid-binding protein AC241_19400 ENOG4105DQ6 Transposase AC241_19410 ENOG41063PX domain protein AC241_19415 ENOG4105D78 K07001 NTE family protein AC241_19420 ENOG4105H20 Sporulation integral membrane protein YlbJ AC241_19430 ENOG4106H78 methyltransferase AC241_19450 ENOG4107TB6 phosphoglycerate mutase AC241_19465 ENOG4106UY4 Inherit from COG: Scp-like extracellular AC241_19515 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AC241_19520 ENOG4105CNI cell division protein FtsW AC241_19535 ENOG4108IAB Phoh family AC241_19555 ENOG4105QA2 AC241_19560 ENOG4105CI3 gtp-binding protein typa AC241_19570 ENOG4105ECY inositol monophosphatase AC241_19590 ENOG4105CXN decarboxylase AC241_19640 ENOG4105CPP Dehydrogenase, E1 component AC241_19655 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AC241_19660 ENOG4108X4Q Hydrolase AC241_19670 ENOG4105CN5 Metallo-Beta-Lactamase AC241_19675 ENOG4107ZYR domain protein AC241_19710 ENOG4108XRC Protein of unknown function (DUF458) AC241_19720 ENOG4107IN1 Protein of unknown function (DUF1797) AC241_19735 ENOG4105EPM Diguanylate phosphodiesterase AC241_19740 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AC241_19755 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AC241_19765 ENOG4105UIN AC241_19805 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AC241_19825 ENOG4108HGU Histidine kinase AC241_19835 ENOG4105CHM Aminotransferase AC241_19840 ENOG4105FKQ transcriptional regulator AC241_19845 ENOG4105EG2 ABC transporter, permease AC241_19855 ENOG4107FKK extracellular solute-binding protein family 1 AC241_19865 ENOG4105CG3 alpha amylase, catalytic region AC241_19910 ENOG4105CHU acetyl-coa acetyltransferase AC241_19945 ENOG4105K7K Transcriptional regulator AC241_19950 ENOG4105DTD Dehydrogenase AC241_19970 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AC241_19995 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AC241_20010 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AC241_20020 ENOG4105BZU Histidine kinase AC241_20040 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AC241_20055 ENOG4105CID antiterminator AC241_20065 ENOG4105FDP GntR family transcriptional regulator AC241_20075 ENOG4105CE4 GlcNAc 6-P deacetylase AC241_20115 ENOG4107ZE5 PPIases accelerate the folding of proteins AC241_20120 ENOG4105PTM secreted protein AC241_20125 ENOG4105J7I hydrolase AC241_20135 ENOG4105G6R Stage v sporulation protein ae AC241_20145 ENOG4105CZ3 stage V sporulation protein ad AC241_20150 ENOG41090VF Stage v sporulation protein ac AC241_20170 ENOG4105C8J )-transporter AC241_20175 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_20185 ENOG41082AN stage II sporulation protein AC241_20190 ENOG4105DZ1 carboxypeptidase AC241_20195 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AC241_20200 ENOG4105DVE abc transporter atp-binding protein AC241_20235 ENOG4105D7N magnesium and cobalt transport protein CorA AC241_20260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AC241_20270 ENOG4105I3K Ferric uptake regulator, Fur family AC241_20275 ENOG4105MZ9 stage II sporulation protein m AC241_20295 ENOG4105CPC Aldo Keto reductase AC241_20305 ENOG4105RHY Pfam:UPF0157 AC241_20325 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AC241_20335 ENOG4105ETE Transcriptional regulator (LacI family AC241_20340 ENOG4108YM7 Gcn5-related n-acetyltransferase AC241_20360 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AC241_20365 ENOG4108R6K riboflavin synthase, subunit alpha AC241_20390 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AC241_20395 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AC241_20410 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AC241_20420 ENOG4105DFD Na H antiporter AC241_20425 ENOG4105CGH 5'-nucleotidase AC241_20450 ENOG4105DBV ornithine carbamoyltransferase AC241_20465 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AC241_20480 ENOG4108IXY short-chain dehydrogenase reductase AC241_20485 ENOG41069FQ Metallo-beta-lactamase superfamily AC241_20490 ENOG4105II7 pyrroline-5-carboxylate reductase AC241_20495 ENOG4105EJQ L-serine dehydratase AC241_20525 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AC241_20545 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AC241_20550 ENOG4105D9U N-acetyltransferase AC241_20565 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AC241_20570 ENOG4108QEG Membrane AC241_20575 ENOG4105CDA abc transporter atp-binding protein AC241_20580 ENOG4105E5Q amino acid AbC transporter AC241_20585 ENOG4108HW3 (ABC) transporter AC241_20600 ENOG4105G7B Protein of unknown function (DUF2992) AC241_20605 ENOG4105E09 nadh pyrophosphatase AC241_20610 ENOG4108QY0 Membrane AC241_20625 ENOG4105C7S Dehydrogenase AC241_20630 ENOG4105CPP Dehydrogenase, E1 component AC241_20645 ENOG4105CKM Branched-chain carboxylic acid kinase AC241_20650 ENOG4107RDP Dehydrogenase AC241_20665 ENOG4108JUB Transcriptional regulator AC241_20675 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AC241_20690 ENOG4107QQR Sporulation AC241_20700 ENOG4105S1Z Stage IV sporulation protein B AC241_20705 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AC241_20710 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AC241_20715 ENOG4105DX0 Hemolysin A AC241_20725 ENOG4105CTB Polyprenyl synthetase AC241_20740 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AC241_20750 ENOG4108ZSR alkaline shock protein AC241_20755 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AC241_20780 ENOG410644B Stage III sporulation protein af AC241_20790 ENOG4105KQ4 Stage iii sporulation protein ad AC241_20795 ENOG4108CQH stage III sporulation protein AC AC241_20800 ENOG4105KR5 Stage iii sporulation protein AC241_20805 ENOG4105CD2 stage iii sporulation protein aa AC241_20830 ENOG4105DC7 peptidase M24 AC241_20835 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AC241_20845 ENOG4105CBJ Metal-dependent enzyme AC241_20855 ENOG4107YBY Hydrolase AC241_20885 ENOG41082GG biotin lipoate A B protein ligase AC241_20890 ENOG4105WZW rhodanese family AC241_20915 ENOG41080TC multidrug resistance protein AC241_20955 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AC241_20970 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AC241_20985 ENOG4105C0D helicase AC241_21070 ENOG4107R6U sodium dicarboxylate symporter AC241_21110 ENOG4105D7V transposase AC241_21115 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AC241_21120 ENOG4105C3R Methionine synthase AC241_21130 ENOG4105C28 cystathionine AC241_21135 ENOG4105C28 cystathionine AC241_21155 ENOG4105C5X domain protein AC241_21165 ENOG4105DKQ ROK family AC241_21175 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AC241_21190 ENOG4108UTW Plays a role in the regulation of phosphate uptake AC241_21195 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AC241_21200 ENOG4105C8U phosphate abc transporter AC241_21205 ENOG4105C8U phosphate abc transporter AC241_21210 ENOG4105EXS phosphate abc transporter AC241_21215 ENOG4107RF6 penicillin-binding protein AC241_21225 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AC241_21250 ENOG4105N80 Ferric uptake regulator, Fur family AC241_21260 ENOG4105FDK ABC transporter AC241_21265 ENOG4108JYZ YitT family AC241_21270 ENOG41069ZM Protein of unknown function (DUF2624) AC241_21295 ENOG4105EGD dinuclear metal center protein, YbgI family AC241_21310 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_21315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AC241_21345 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AC241_21350 ENOG4105KG3 cytidine deaminase AC241_21355 ENOG4107YR5 Diacylglycerol kinase AC241_21360 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AC241_21365 ENOG4105CTJ Metal Dependent Phosphohydrolase AC241_21370 ENOG4105C9A Phoh family AC241_21380 ENOG41068P3 sporulation protein YqfC AC241_21390 ENOG4105KTH gatB Yqey AC241_21400 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AC241_21405 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AC241_21435 ENOG4105CSA Coproporphyrinogen iii oxidase AC241_21440 ENOG4105KVH Transcriptional regulator AC241_21465 ENOG4105TQK DNA polymerase iii, delta' subunit AC241_21475 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AC241_21480 ENOG4108UK2 deaminase AC241_21485 ENOG4105KQC Competence protein AC241_21495 ENOG4105DXX methyltransferase AC241_21505 ENOG4108WF2 Metal Dependent Phosphohydrolase AC241_21515 ENOG410812S Rna-binding protein AC241_21525 ENOG4105CQW ribosome biogenesis GTPase YqeH AC241_21530 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AC241_21545 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_21565 ENOG4108TVJ Nitroreductase AC241_21580 ENOG4105G6Z alkaline phosphatase AC241_21585 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AC241_21590 ENOG4108MUZ hydrolase AC241_21625 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AC241_21630 ENOG4105MIR Phenylalanine 4-monooxygenase AC241_21640 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AC241_21680 ENOG4105S6R Iron-hydroxamate transporter permease subunit AC241_21685 ENOG4108V5C ABC transporter AC241_21695 ENOG4105DQ6 Transposase AC241_21705 ENOG4108EKI Dehydrogenase AC241_21710 ENOG4105C28 cystathionine AC241_21740 ENOG4107XRG penicillin-binding protein AC241_21745 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AC241_21755 ENOG4105CFP Peptidase U32 AC241_21760 ENOG4105XYU peptidase (U32 family) AC241_21765 ENOG4108VQJ O-methyltransferase AC241_21770 ENOG4105HHA aminodeoxychorismate lyase AC241_21790 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AC241_21800 ENOG4105C02 permease AC241_21815 ENOG41060CR AC241_21820 ENOG4105C7H Helicase, RecD TraA family AC241_21830 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AC241_21835 ENOG4105C3J Cysteine desulfurase AC241_21845 ENOG4105D1H recombination factor protein RarA AC241_21850 ENOG4108VCI transcription factor, rsfa family AC241_21860 ENOG4105CUZ uba thif-type nad fad binding protein AC241_21870 ENOG4105CUT histidyl-tRNA synthetase AC241_21890 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AC241_21900 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AC241_21905 ENOG41076HS cation diffusion facilitator family transporter AC241_21910 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AC241_21920 ENOG4105CKP Polysaccharide Biosynthesis Protein AC241_21925 ENOG4108QG2 Membrane AC241_21935 ENOG4105VIE preprotein translocase, subunit YajC AC241_21950 ENOG41061AI Protein of unknown function (DUF2905) AC241_21965 ENOG4108HUF Transporter AC241_21995 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AC241_22000 ENOG4108IYU L-aspartate oxidase AC241_22015 ENOG4108RPX mosc domain containing protein AC241_22020 ENOG4105CQC Prephenate dehydratase AC241_22035 ENOG4105C19 ABC transporter AC241_22040 ENOG4105EWM Histidine kinase AC241_22065 ENOG4105X36 (ribosomal) protein AC241_22075 ENOG4105C03 ribonuclease AC241_22090 ENOG4107QMS site-determining protein AC241_22105 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AC241_22110 ENOG4105DFF Rod shape-determining protein mreb AC241_22130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AC241_22135 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AC241_22145 ENOG41068KH stage VI sporulation protein D AC241_22155 ENOG4105D52 delta-aminolevulinic acid dehydratase AC241_22180 ENOG4105K56 Transcriptional regulator AC241_22200 ENOG4108IUQ atp-dependent protease AC241_22230 ENOG4108QCI YvbH-like oligomerisation region AC241_22250 ENOG4105M59 Phosphodiesterase, mj0936 family AC241_22265 ENOG4108XJQ germination protein AC241_22275 ENOG4108PCX Major Facilitator AC241_22285 ENOG4105KBX Transcriptional regulator, TetR family AC241_22295 ENOG4105PFC Transcriptional regulator AC241_22305 ENOG4105DZC cytosine deaminase AC241_22310 ENOG41067S9 phage shock protein C, PspC AC241_22315 ENOG4108JCI Transcriptional regulator AC241_22325 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AC241_22330 ENOG4108Z40 Transcriptional regulator AC241_22335 ENOG4105RHA ABC transporter, permease AC241_22340 ENOG4108IUX (ABC) transporter AC241_22345 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AC241_22350 ENOG4105ER2 Ompa motb domain protein AC241_22355 ENOG4105E14 MotA TolQ exbB proton channel AC241_22360 ENOG4108VXD carboxy-peptidase AC241_22370 ENOG4105E33 succinate dehydrogenase AC241_22380 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AC241_22390 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AC241_22395 ENOG4105K63 Thioredoxin AC241_22400 ENOG4105C10 Electron transfer flavoprotein AC241_22405 ENOG4105BZJ Electron transfer flavoprotein AC241_22410 ENOG41060WC Enoyl-CoA hydratase AC241_22415 ENOG4107Z3H Transcriptional regulator, TetR family AC241_22420 ENOG4105CEY Amp-dependent synthetase and ligase AC241_22430 ENOG4105J76 Periplasmic binding protein AC241_22435 ENOG4105S6R Iron-hydroxamate transporter permease subunit AC241_22485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC241_22500 ENOG4105DR4 Methyltransferase AC241_22510 ENOG4105KFN sortase, SrtB family AC241_22515 ENOG4105E0A ABC, transporter AC241_22530 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AC241_22540 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AC241_22550 ENOG4105FE9 pseudouridine synthase AC241_22565 ENOG4105DCG PHP domain protein AC241_22580 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AC241_22600 ENOG4105C5S asparaginyl-tRNA synthetase AC241_22605 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AC241_22615 ENOG4108RWN rrna methyltransferase AC241_22640 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC241_22645 ENOG4105CW7 secretion protein, HlyD family AC241_22650 ENOG4108JGH Tetr family transcriptional regulator AC241_22655 ENOG4105CN9 Peptidase m42 family protein AC241_22675 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AC241_22680 ENOG4105C22 threonyL-tRNA synthetase AC241_22685 ENOG4108TDW sporulation protein YtxC AC241_22710 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AC241_22715 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AC241_22720 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AC241_22730 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AC241_22735 ENOG4105C2M dna polymerase I AC241_22740 ENOG4105BZU Histidine kinase AC241_22745 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC241_22765 ENOG4108HMX isocitrate dehydrogenase (NADP) AC241_22770 ENOG4105BZN citrate synthase AC241_22785 ENOG4108REF Sporulation integral membrane protein ytvi AC241_22790 ENOG4105FS0 cytoplasmic membrane protein AC241_22815 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AC241_22820 ENOG4105C6K Malic enzyme AC241_22825 ENOG4105C0B DNA polymerase III (alpha subunit) AC241_22830 ENOG4105VV2 AC241_22840 ENOG4105SFS phosphoesterase RecJ domain protein AC241_22870 ENOG4105DC7 peptidase M24 AC241_22900 ENOG4105Z7P Acetyltransferase (GNAT) family AC241_22905 ENOG41082W1 Cupin 2, conserved barrel domain protein AC241_22925 ENOG4107YZX Universal stress protein AC241_22965 ENOG4108JYZ YitT family AC241_22985 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AC241_22995 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AC241_23000 ENOG4105KBJ sporulation protein ytfj AC241_23015 ENOG4105EFZ amidohydrolase AC241_23025 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AC241_23050 ENOG4106KR7 LysR family Transcriptional regulator AC241_23060 ENOG4105U5Y Transcriptional regulator AC241_23070 ENOG4105C28 cystathionine AC241_23100 ENOG4105EMN RNA polymerase sigma factor AC241_23110 ENOG4108UW5 maltose o-acetyltransferase AC241_23120 ENOG4105F1V Acetoin utilization protein AC241_23125 ENOG4105W87 Cbs domain AC241_23130 ENOG4105DGU Histone deacetylase AC241_23145 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AC241_23155 ENOG4107SNB ankyrin repeat protein YahD AC241_23160 ENOG4105EP9 oxidoreductase AC241_23190 ENOG4105ETE Transcriptional regulator (LacI family AC241_23200 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AC241_23205 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AC241_23210 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AC241_23230 ENOG4105C88 aminopeptidase AC241_23255 ENOG4108IPJ Membrane AC241_23280 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AC241_23290 ENOG4108VDD TRNA binding domain protein AC241_23320 ENOG4105C8F Beta-lactamase domain protein AC241_23335 ENOG4108V15 phosphotransferase enzyme family AC241_23340 ENOG4108IUM Glycogen debranching enzyme AC241_23355 ENOG4107QSE Dipeptidase AC241_23360 ENOG4105YW5 deoR family transcriptional regulator AC241_23375 ENOG4105CBX hi0933 family AC241_23410 ENOG4108VJ1 Transcriptional regulator (CarD family AC241_23415 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AC241_23420 ENOG4105CSC Glucose uptake protein AC241_23435 ENOG4108ZAF Molybdopterin AC241_23440 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AC241_23445 ENOG4105CVM Molybdenum cofactor synthesis domain protein AC241_23455 ENOG4105D06 uba thif-type nad fad binding protein AC241_23460 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AC241_23480 ENOG41085GJ domain protein AC241_23490 ENOG4105DWV Homoserine O-trans-acetylase AC241_23500 ENOG4108B31 Spore germination protein AC241_23525 ENOG4105C8T Leucyl-tRNA synthetase AC241_23530 ENOG410605W Major Facilitator AC241_23535 ENOG4107S91 Sodium hydrogen exchanger AC241_23540 ENOG4105NCW Trka-c domain protein AC241_23555 ENOG4105C19 ABC transporter AC241_23575 ENOG4105N5T Radical SAM Protein AC241_23600 ENOG4105E8V Alpha Beta Hydrolase Fold protein AC241_23605 ENOG4108Z0R Transferase AC241_23610 ENOG4105YVM Phosphoesterase, PA-phosphatase related AC241_23615 ENOG4105BZF Glycosyl transferase (Group 1 AC241_23625 ENOG4108RIR Molybdenum cofactor biosynthesis protein AC241_23705 ENOG4105BZU Histidine kinase AC241_23710 ENOG4105BZU Histidine kinase AC241_23715 ENOG4105CH6 catalase AC241_23720 ENOG4107S9D Alpha beta hydrolase AC241_23725 ENOG4107T7U Sulfatase AC241_23740 ENOG4105D2X ABC transporter substrate-binding protein AC241_23750 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AC241_23815 ENOG4108V2W Carbonate dehydratase AC241_23820 ENOG4105C4M (Ubiquinol oxidase) subunit I AC241_23825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AC241_23865 ENOG41087YS Phage shock protein A AC241_23890 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AC241_23895 ENOG4105BZU Histidine kinase AC241_23900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_23925 ENOG4108UGV hypoxanthine phosphoribosyltransferase AC241_23930 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AC241_23955 ENOG4105DQ6 Transposase AC241_24005 ENOG4107ZTW SNARE associated Golgi AC241_24020 ENOG4105C19 ABC transporter AC241_24025 ENOG41086D8 Transcriptional regulator AC241_24040 ENOG41082BM Transcriptional regulator, arsr family AC241_24050 ENOG4105EMN RNA polymerase sigma factor AC241_24090 ENOG4105C6Z Gluconate AC241_24095 ENOG4105FDP GntR family transcriptional regulator AC241_24115 ENOG41069H0 dihydroorotase EC 3.5.2.3 AC241_24135 ENOG4105DTQ mandelate racemase muconate lactonizing AC241_24145 ENOG4108IPT Naphthoate synthase AC241_24150 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AC241_24155 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AC241_24160 ENOG4105E4F Isochorismate synthase AC241_24165 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AC241_24175 ENOG4105VEQ Cold shock protein AC241_24215 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AC241_24220 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AC241_24230 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AC241_24240 ENOG4108Q5F Tetr family transcriptional regulator AC241_24375 ENOG4105KT7 mgtC SapB transporter AC241_24380 ENOG4107PBV potassium channel AC241_24400 ENOG4105WG9 Conserved Protein AC241_24410 ENOG4105CHM Aminotransferase AC241_24415 ENOG4108ZB6 transcriptional regulator AsnC family AC241_24420 ENOG4105C5I Dehydrogenase AC241_24425 ENOG4108MUZ hydrolase AC241_24435 ENOG4105C87 Aminotransferase class I and II AC241_24450 ENOG4105Y38 Kinase-associated protein B AC241_24460 ENOG4107R3E Citrate transporter AC241_24475 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AC241_24480 ENOG4105KA0 thioesterase Superfamily protein AC241_24495 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AC241_24515 ENOG41069ER domain protein AC241_24530 ENOG4105CEP NADH dehydrogenase AC241_24560 ENOG4105EWC Purine nucleoside phosphorylase AC241_24570 ENOG4108VQJ O-methyltransferase AC241_24585 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AC241_24610 ENOG4108JJA ABC, transporter AC241_24615 ENOG4105C4B ABC transporter, permease AC241_24620 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AC241_24685 ENOG41083MR nifu domain-containing protein AC241_24700 ENOG4108W5N phosphatidylglycerophosphatase a AC241_24720 ENOG4105DAX Pfam:DUF2983 AC241_24730 ENOG4105DYS nad(p)h dehydrogenase (quinone) AC241_24735 ENOG4105D4U had-superfamily hydrolase, subfamily iia AC241_24750 ENOG4105CBT Fructose-1,6-bisphosphatase AC241_24770 ENOG4105MMD transcriptional regulator AC241_24775 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AC241_24780 ENOG4107TXC Transcriptional regulator AC241_24785 ENOG41090T1 Membrane AC241_24810 ENOG4105FAA peptidase M23 AC241_24815 ENOG4108YTE sporulation protein YunB AC241_24820 ENOG4105KZD Domain of unknown function (DUF1805) AC241_24825 ENOG4107R8B 5'-nucleotidase AC241_24830 ENOG4105DIW FeS assembly protein SUFB AC241_24835 ENOG4108UNV SUF system FeS assembly protein, NifU family AC241_24840 ENOG4105C9B Cysteine desulfurase AC241_24845 ENOG4105JRK feS assembly protein SufD AC241_24850 ENOG4105C3K feS assembly ATPase SufC AC241_24855 ENOG4105D01 (LipO)protein AC241_24860 ENOG4105D01 (LipO)protein AC241_24865 ENOG4108UMI ABC transporter, permease AC241_24870 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AC241_24895 ENOG41080E8 Transcriptional regulator, Spx MgsR family AC241_24915 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AC241_24930 ENOG4108W8B Beta-lactamase domain protein AC241_24935 ENOG4105C1G acyl-Coa dehydrogenase AC241_24945 ENOG4105CHU acetyl-coa acetyltransferase AC241_24960 ENOG4105DZ1 carboxypeptidase AC241_24980 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AC241_24995 ENOG4108SUT Major Facilitator Superfamily AC241_25000 ENOG4107R7I amino acid AC241_25015 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AC241_25025 ENOG4107AYK membrAne AC241_25060 ENOG4107ZTW SNARE associated Golgi AC241_25070 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AC241_25075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_25080 ENOG4105BZU Histidine kinase AC241_25110 ENOG4105C8Q Methyl-accepting chemotaxis AC241_25115 ENOG4105VG1 fes assembly suf system protein AC241_25120 ENOG4105D4Y metalloprotease AC241_25140 ENOG4107T5V SNARE associated Golgi AC241_25145 ENOG4107S91 Sodium hydrogen exchanger AC241_25150 ENOG4105NCW Trka-c domain protein AC241_25165 ENOG4108RMU ferritin dps family protein AC241_25185 ENOG4108URH decarboxylase AC241_25195 ENOG41090A1 ferritin AC241_25205 ENOG4105D9N nucleoside AC241_25210 ENOG4105D9N nucleoside AC241_25225 ENOG4108RYK Nad-dependent epimerase dehydratase AC241_25240 ENOG4105CV8 reductase AC241_25245 ENOG4105F27 Major Facilitator AC241_25250 ENOG4105KVH Transcriptional regulator AC241_25265 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AC241_25270 ENOG4105D4A Cell wall formation (By similarity) AC241_25290 ENOG4105WMR Protein CrcB homolog AC241_25295 ENOG4105WMR Protein CrcB homolog AC241_25315 ENOG4105C5H ABC transporter AC241_25320 ENOG4108MK9 spermidine N(1)-acetyltransferase AC241_25325 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AC241_25335 ENOG4105KVH Transcriptional regulator AC241_25345 ENOG4105VPS UPF0291 protein AC241_25350 ENOG4108W2Y isochorismatase AC241_25385 ENOG4108IPW abc transporter atp-binding protein AC241_25390 ENOG4105CM4 permease protein AC241_25415 ENOG4105EYF MMPL domain protein AC241_25425 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AC241_25435 ENOG4105XZU Preprotein translocase, subunit SecG AC241_25440 ENOG41067MG lrgb family AC241_25490 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_25495 ENOG4105RHA ABC transporter, permease AC241_25500 ENOG4108IUX (ABC) transporter AC241_25505 ENOG4105BZU Histidine kinase AC241_25535 ENOG41090VF Stage v sporulation protein ac AC241_25540 ENOG4105CZ3 stage V sporulation protein ad AC241_25555 ENOG4108QY0 Membrane AC241_25560 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AC241_25565 ENOG4105KRI phosphocarrier protein (HPr AC241_25575 ENOG4105CHW UPF0052 protein AC241_25580 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AC241_25585 ENOG4108Z4K mutator MutT protein AC241_25595 ENOG4105C3M thioredoxin reductase AC241_25605 ENOG4108S4C acetyltransferase AC241_25625 ENOG41086DT Membrane protein of unknown function AC241_25635 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AC241_25655 ENOG4107TXC Transcriptional regulator AC241_25685 ENOG4105HMI Membrane AC241_25690 ENOG4105DUM transcriptional regulator, lysR family AC241_25700 ENOG4108WS4 fmn reductase AC241_25715 ENOG4105BZ1 (ABC) transporter AC241_25725 ENOG4105CN1 protease AC241_25730 ENOG4105CRP Part of the ABC transporter FtsEX involved in AC241_25735 ENOG4105CAK Cell division ATP-binding protein ftsE AC241_25750 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AC241_25760 ENOG4105MS2 ribosomal subunit Interface protein AC241_25765 ENOG4105VEQ Cold shock protein AC241_25770 ENOG41081UC Inherit from COG: Competence protein AC241_25785 ENOG4105KVH Transcriptional regulator AC241_25795 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AC241_25800 ENOG4108KGH TRANSCRIPTIONal AC241_25805 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AC241_25810 ENOG4105C6Y Udp-glucose 6-dehydrogenase AC241_25815 ENOG4105ESV Glycosyl transferase, family 4 AC241_25825 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AC241_25845 ENOG4105F8D glycoside hydrolase family 4 AC241_25850 ENOG4105VCP PTS System AC241_25855 ENOG4105CK1 PTS System AC241_25865 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AC241_25870 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AC241_25875 ENOG4105VCP PTS System AC241_25885 ENOG4105VZJ PTS System AC241_25905 ENOG4105ECB domain protein AC241_25910 ENOG4107RSM transcriptional regulator AC241_25960 ENOG4105DAA L-lactate AC241_25970 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AC241_25980 ENOG4105E0M Sulfatase AC241_26005 ENOG4107R8N Glycosyl transferase, family 2 AC241_26015 ENOG4105C94 Transporter AC241_26020 ENOG41069ER domain protein AC241_26045 ENOG4105KBK Zinc finger, swim domain protein AC241_26050 ENOG4105C0D helicase AC241_26055 ENOG4105DQ6 Transposase AC241_26090 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_26100 ENOG4107RBB ABC transporter, permease AC241_26105 ENOG4105C19 ABC transporter AC241_26115 ENOG4105CXY transporter AC241_26130 ENOG4105BZU Histidine kinase AC241_26135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_26140 ENOG4105CMR udp-glucose 4-epimerase AC241_26150 ENOG4108KGH TRANSCRIPTIONal AC241_26160 ENOG4107TAE Glycosyl transferase (Group 1 AC241_26165 ENOG4105K64 Glycosyl transferase, family 2 AC241_26190 ENOG4105D3Q Sugar transferase AC241_26195 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AC241_26200 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AC241_26205 ENOG4107YJ4 chain length determinant protein AC241_26210 ENOG4105HTX biosynthesis protein AC241_26215 ENOG4107YJ4 chain length determinant protein AC241_26230 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AC241_26240 ENOG4105FRN stage II sporulation protein AC241_26255 ENOG4105DY9 regulatoR AC241_26275 ENOG4106778 Protein of unknown function (DUF1146) AC241_26280 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AC241_26285 ENOG4105C8S subunit m AC241_26290 ENOG4105D65 subunit l AC241_26315 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AC241_26320 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AC241_26330 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AC241_26335 ENOG4105BZU Histidine kinase AC241_26355 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AC241_26385 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AC241_26390 ENOG41062M3 atp synthase AC241_26410 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AC241_26415 ENOG4108UIC UPF0340 protein AC241_26420 ENOG4108YZG isomerase AC241_26435 ENOG4108VGI doxx family AC241_26450 ENOG4107XC4 flavin reductase domain protein, FMN-binding AC241_26465 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AC241_26475 ENOG4108ZXQ stage ii sporulation protein r AC241_26480 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AC241_26485 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AC241_26500 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AC241_26505 ENOG4105CBT Fructose-1,6-bisphosphatase AC241_26510 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AC241_26545 ENOG4105C1G acyl-Coa dehydrogenase AC241_26550 ENOG4105C1G acyl-Coa dehydrogenase AC241_26555 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AC241_26565 ENOG4105DF6 Fe-S oxidoreductase AC241_26580 ENOG4105BZU Histidine kinase AC241_26595 ENOG4105D4Y metalloprotease AC241_26605 ENOG4105BZU Histidine kinase AC241_26610 ENOG4105KCT ABC transporter AC241_26615 ENOG4108M15 ABC transporter AC241_26620 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AC241_26630 ENOG4105IIU Aminopeptidase AC241_26650 ENOG4105EMN RNA polymerase sigma factor AC241_26660 ENOG410684U Domain of unknown function (DUF1934) AC241_26685 ENOG4105CYW agmatinase AC241_26695 ENOG4105DXB Major Facilitator superfamily AC241_26700 ENOG4107SWG transcriptional regulator MERR family AC241_26705 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AC241_26710 ENOG4105BZ4 penicillin-binding protein AC241_26715 ENOG4108XFG YwhD family AC241_26720 ENOG4108Z4T Peptidase M50 AC241_26725 ENOG41069HH 4-oxalocrotonate tautomerase AC241_26730 ENOG4105DCI Phosphohydrolase AC241_26735 ENOG4108MES Periplasmic binding protein AC241_26740 ENOG4105E0A ABC, transporter AC241_26745 ENOG4105EHG Permease protein AC241_26750 ENOG4105DQ5 transport system permease protein AC241_26760 ENOG4108VCI transcription factor, rsfa family AC241_26765 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AC241_26770 ENOG4108IJ2 phosphate acetyltransferase AC241_26775 ENOG4107UEZ chlorite dismutase AC241_26785 ENOG4108VKI Cell wall hydrolase AC241_26805 ENOG4107SVH Potassium channel protein AC241_26815 ENOG410667J hydrolase AC241_26820 ENOG4105VCH membrane AC241_26830 ENOG4108TU7 Inherit from COG: (ABC) transporter AC241_26835 ENOG4105CJ1 ABC, transporter AC241_26840 ENOG41090WU lipolytic protein G-D-S-L family AC241_26855 ENOG4105D6E homoserine dehydrogenase AC241_26860 ENOG4105CVG Homoserine O-transsuccinylase AC241_26880 ENOG4108Y4K DNA-binding transcriptional activator AC241_26890 ENOG4105WH1 Two component transcriptional regulator luxr family AC241_26895 ENOG4105BZU Histidine kinase AC241_26900 ENOG4105DWF phosphomethylpyrimidine kinase AC241_26905 ENOG4105BZU Histidine kinase AC241_26910 ENOG4105VCD cytoplasmic protein AC241_26915 ENOG4105D22 carbon starvation protein AC241_26920 ENOG4105DY9 regulatoR AC241_26925 ENOG41079KZ Major Facilitator Superfamily AC241_26935 ENOG4105CG5 Glycosyl transferase (Group 1 AC241_26945 ENOG4105EN6 Membrane AC241_26950 ENOG4106YBV Methyl-accepting chemotaxis AC241_26960 ENOG4108S4H thioesterase Superfamily protein AC241_26965 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AC241_26980 ENOG4105K64 Glycosyl transferase, family 2 AC241_26995 ENOG4105CKK Glycosyl transferase, family 2 AC241_27005 ENOG4108IG5 Transcriptional regulator AC241_27010 ENOG4105C5H ABC transporter AC241_27015 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AC241_27025 ENOG41067SE Tetr family transcriptional regulator AC241_27035 ENOG4105E0X reductase AC241_27040 ENOG4106F5Q Membrane AC241_27055 ENOG4108NEV two component transcriptional regulator, LytTR family AC241_27060 ENOG4108HRK Histidine kinase AC241_27065 ENOG4107RGD Major Facilitator superfamily AC241_27080 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AC241_27090 ENOG4105IW1 AmiS UreI transporter AC241_27100 ENOG4105CMR udp-glucose 4-epimerase AC241_27105 ENOG4108UT2 hemolysin iii AC241_27115 ENOG4105C1J atp-dependent rna helicase AC241_27120 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) AC241_27125 ENOG4105DPN Oligoendopeptidase f AC241_27135 ENOG4105BZU Histidine kinase AC241_27150 ENOG4105C0H protease AC241_27155 ENOG4105Q2H domain protein AC241_27170 ENOG4105BZU Histidine kinase AC241_27175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_27200 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AC241_27205 ENOG4105CDU Replicative dna helicase AC241_27215 ENOG4105BZR domain protein AC241_27220 ENOG4108XMW Membrane AC241_27230 ENOG4108UUM single-stranded DNA-binding protein AC241_27240 ENOG4105C3G gtp-binding protein AC241_27245 ENOG4105VDK protein, conserved in bacteria AC241_27250 ENOG4105D8X mechanosensitive ion channel AC241_27255 ENOG4108ZDA Sporulation protein YyaC AC241_27260 ENOG4105FA0 parb-like partition protein AC241_27265 ENOG4107QJE Chromosome Partitioning Protein AC241_27280 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AC241_27285 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AC241_27295 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AC241_27320 ENOG4107XZC Restriction modification system DNA (Specificity AC241_27350 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AC241_27350 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 AC241_27370 ENOG4105EKQ RNA-directed DNA polymerase AC241_27445 ENOG4105D7V transposase AC241_27450 ENOG4105ETE Transcriptional regulator (LacI family AC241_27455 ENOG4105IE8 Alpha-ketoglutarate permease AC241_27460 ENOG4105CK5 oxidoreductase AC241_27485 ENOG4105D2N Aldolase AC241_27490 ENOG4105DH8 myo-inositol catabolism AC241_27530 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AC241_27535 ENOG4105C37 (CBS) domain AC241_27545 ENOG4105D7V transposase AC241_27615 ENOG4105FAW cDP-glucose 4,6-dehydratase AC241_27630 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AC241_27665 ENOG4105C5E polysaccharide biosynthesis protein AC241_27670 ENOG4105C1B dTDP-glucose 4-6-dehydratase AC241_27675 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AC241_27680 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AC241_27725 ENOG41085GJ domain protein AC241_27745 ENOG4105CJZ response regulator AC241_27755 ENOG4105BZU Histidine kinase AC241_27760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_27770 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AC241_27800 ENOG4105DUX Transporter AC241_27805 ENOG4105F6J Alpha beta hydrolase fold AC241_27855 ENOG4108VXD carboxy-peptidase AC241_27860 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AC241_27865 ENOG4105D9M gamma-glutamylcysteine synthetase AC241_27875 ENOG4105C4W S-formylglutathione hydrolase AC241_27885 ENOG4105KVH Transcriptional regulator AC241_27890 ENOG4107RBB ABC transporter, permease AC241_27895 ENOG4105C19 ABC transporter AC241_27915 ENOG4105CKK Glycosyl transferase, family 2 AC241_27920 ENOG4105EDW glycosyl transferase, family 39 AC241_27925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_27930 ENOG4105BZU Histidine kinase AC241_27955 ENOG4105EFA 4-hydroxyphenylacetate AC241_27985 ENOG4105NA0 Transcriptional regulator AC241_27995 ENOG4105C19 ABC transporter AC241_28005 ENOG4105DJB Major Facilitator Superfamily AC241_28010 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AC241_28025 ENOG4108J5H Homocysteine s-methyltransferase AC241_28030 ENOG4108IQI permease AC241_28040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AC241_28045 ENOG4105YVS arsR family transcriptional regulator AC241_28055 ENOG4105CJW magnesium transporter AC241_28060 ENOG4105CNI cell division protein FtsW AC241_28085 ENOG4105BZU Histidine kinase AC241_28090 ENOG4105C44 Serine transporter AC241_28095 ENOG4105EJQ L-serine dehydratase AC241_28105 ENOG4105MZU cell filamentation protein AC241_28120 ENOG4105DVH amino acid AC241_28140 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AC241_28150 ENOG4105BZ4 penicillin-binding protein AC241_28170 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AC241_28175 ENOG4108V2W Carbonate dehydratase AC241_28190 ENOG4107WD8 ABC transporter, permease AC241_28195 ENOG4105E98 transcriptional regulator DeoR family AC241_28200 ENOG4107XGZ Hydrolase AC241_28230 ENOG4105CJN penicillin-binding protein AC241_28335 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AC241_28390 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AC241_28405 ENOG4105C19 ABC transporter AC241_28420 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AC241_28425 ENOG4105W1Y Transcriptional regulator AC241_28435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_28440 ENOG4105BZU Histidine kinase AC241_28445 ENOG4107VMI polysaccharide deacetylase AC241_28460 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AC241_28475 ENOG4105BZ1 (ABC) transporter AC241_28485 ENOG4108WUH Transcriptional regulator, TetR family AC241_28495 ENOG4105ST3 Transcriptional regulator AC241_28500 ENOG4105C0R drug resistance transporter emrb qaca subfamily AC241_28625 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AC241_28685 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AC241_28740 ENOG4105CMG Carbohydrate kinase AC241_28750 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AC241_28795 ENOG4105EKQ RNA-directed DNA polymerase AC241_28800 ENOG4105K4H Nlp p60 protein AC241_28935 ENOG4105K4H Nlp p60 protein AC241_28970 ENOG4105BZU Histidine kinase AC241_28975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AC241_28980 ENOG4105C0H protease AC241_28985 ENOG4107WD8 ABC transporter, permease AC241_29005 ENOG4105D7V transposase AC241_29020 ENOG4108W0I acetyltransferase AC241_29025 ENOG4107QQG Dehydrogenase AC241_29030 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AC241_29035 ENOG4108IAJ Nad-dependent epimerase dehydratase AC241_29040 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AC241_29055 ENOG4105FJR Lmbe family AC241_29065 ENOG4105IIU Aminopeptidase AC241_29070 ENOG4108SC4 )-transporter AC241_29110 ENOG4108IND Tetr family transcriptional regulator AC241_29150 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AC241_29400 ENOG4108IMY Transcriptional regulator AC241_29415 ENOG4107VMI polysaccharide deacetylase AC241_29425 ENOG4105CAQ asparagine synthetase AC241_29445 ENOG41082BM Transcriptional regulator, arsr family AC241_29475 ENOG4105K70 DNA-binding protein AC241_29595 ENOG4105DQ6 Transposase AC241_29625 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AC241_29630 ENOG4105C6Y Udp-glucose 6-dehydrogenase AC241_29640 ENOG4107T8Q Glycosyl transferase (Group 1 AC241_29805 ENOG4105CJW magnesium transporter AC241_29895 ENOG4105DG6 mannose-6-phosphate isomerase AC241_29900 ENOG4105DM4 PTS System AC241_29920 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AC241_29965 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AC241_30010 ENOG4105C19 ABC transporter AC241_30025 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AC241_30210 ENOG4105CSV Glutaminase AC241_30225 ENOG4105E1K spore germination protein AC241_30250 ENOG4105DKT Transcriptional regulator AC241_30260 ENOG4105E09 nadh pyrophosphatase AC241_30275 ENOG4105K70 DNA-binding protein AC241_30305 ENOG4108FPN Integrase AC241_30390 ENOG4105KRN Transcriptional regulator, abrb family AC241_30430 ENOG4105WQG acetyltransferase AC241_30525 ENOG4105EKQ RNA-directed DNA polymerase AC241_30700 ENOG4105DQ6 Transposase AC241_30715 ENOG4105DQ6 Transposase AC241_30770 ENOG4105DQ6 Transposase AC241_30795 ENOG4107RF6 penicillin-binding protein AC241_30880 ENOG4105US7 Histidine kinase AC241_30900 ENOG4108VXD carboxy-peptidase AC241_30960 ENOG4105DQ6 Transposase AC241_31150 ENOG4105BZU Histidine kinase AC241_31200 ENOG4105K4H Nlp p60 protein AC241_31290 ENOG4107QJE Chromosome Partitioning Protein AC241_31350 ENOG4108JJA ABC, transporter AC241_31395 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AC241_31400 ENOG4105RHA ABC transporter, permease AC241_31405 ENOG4108IUX (ABC) transporter AC241_31435 ENOG4105BZ1 (ABC) transporter AC241_31440 ENOG4105VZ8 Transcriptional regulator AC241_31475 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AC241_31515 ENOG4105VZ8 Transcriptional regulator AC241_31530 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AC241_31615 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) AC241_31700 ENOG4108IMY Transcriptional regulator AC241_31910 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AC241_31915 ENOG410880H cysteine synthase AC241_31920 ENOG4105C87 Aminotransferase class I and II AC241_31925 ENOG4107Y9U Membrane AC241_31930 ENOG4105KRN Transcriptional regulator, abrb family AC241_31935 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AC241_31940 ENOG4105K70 DNA-binding protein AC241_31990 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AC241_32155 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AC241_32190 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AC241_32325 ENOG41067QW Transcriptional regulator