locus-tag class description B4918_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B4918_00015 ENOG410848D S4 domain protein YaaA B4918_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B4918_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B4918_00100 ENOG4105ZMH deoxynucleoside kinase B4918_00110 ENOG4105GTG Isochorismatase B4918_00120 ENOG4108Z6B deaminase B4918_00130 ENOG4105C6E dna polymerase iii B4918_00150 ENOG41067KS pro-sigma K processing B4918_00185 ENOG4105CXN decarboxylase B4918_00195 ENOG4105FA2 dna polymerase iii B4918_00200 ENOG4105MA4 psp1 domain protein B4918_00210 ENOG41060K3 Methyltransferase B4918_00220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B4918_00225 ENOG4105KRN Transcriptional regulator, abrb family B4918_00230 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B4918_00235 ENOG4105F8V Hydrolase, tatD family B4918_00240 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) B4918_00250 ENOG4105XFA sporulation peptidase YabG B4918_00255 ENOG4105W42 Veg protein B4918_00270 ENOG4105DFT pur operon repressor B4918_00280 ENOG4105KME endoribonuclease L-psp B4918_00295 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B4918_00300 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) B4918_00310 ENOG4108JA2 transcriptioN-repair coupling factor B4918_00315 ENOG4108M14 stage v sporulation protein t B4918_00325 ENOG4108IY2 MazG family B4918_00330 ENOG41082I2 s4 domain protein B4918_00335 ENOG4105VYY sporulation protein yabp B4918_00350 ENOG41060GV RNA binding s1 domain protein B4918_00370 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) B4918_00375 ENOG4108UGV hypoxanthine phosphoribosyltransferase B4918_00380 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B4918_00395 ENOG4105C6T cysteine synthase B4918_00400 ENOG4105CRQ synthase (Component I) B4918_00405 ENOG4105DDQ anthranilate synthase B4918_00410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 B4918_00415 ENOG4105EEI dihydropteroate synthase B4918_00420 ENOG4105KRF dihydroneopterin aldolase B4918_00425 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B4918_00435 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B4918_00525 ENOG4108Z0C Uvrb UvrC protein B4918_00540 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B4918_00550 ENOG4105CTP PilT protein domain protein B4918_00570 ENOG4105D7W serine acetyltransferase B4918_00585 ENOG4105C2N RNA methyltransferase TrmH family group 3 B4918_00590 ENOG4105M0M Tetracycline resistance protein B4918_00595 ENOG4105QIV RNA polymerase B4918_00610 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B4918_00635 ENOG4107Y49 methyltransferase B4918_00645 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B4918_00650 ENOG4105XPM ribosomal protein B4918_00760 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B4918_00785 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B4918_00795 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B4918_00805 ENOG41067V7 50S ribosomal protein L36 B4918_00830 ENOG4108JJB ABC transporter B4918_00835 ENOG4108JJB ABC transporter B4918_00840 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B4918_00845 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B4918_00870 ENOG4105D1F ATP-binding protein B4918_00885 ENOG4108NMV polysaccharide deacetylase B4918_00965 ENOG41066UZ arginase EC 3.5.3.1 B4918_00975 ENOG4105C8B TIGR00159 family B4918_00980 ENOG4107U5W ybbr family B4918_00995 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B4918_01015 ENOG4108PSK reductase B4918_01020 ENOG4108UMI ABC transporter, permease B4918_01025 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B4918_01030 ENOG4105D01 (LipO)protein B4918_01035 ENOG4105CB2 alcohol dehydrogenase B4918_01045 ENOG4105IQ5 FAD linked oxidase domain protein B4918_01060 ENOG4105C2C drug resistance transporter, Bcr CflA B4918_01080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B4918_01085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_01090 ENOG4105C3U ABC transporter B4918_01095 ENOG4108JQ7 (ABC) transporter B4918_01120 ENOG4108J59 Extracellular solute-binding protein, family 5 B4918_01140 ENOG4105E0C molybdate abc transporter B4918_01145 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B4918_01150 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family B4918_01185 ENOG4105F6E Acyl-transferase B4918_01215 ENOG4105EKQ RNA-directed DNA polymerase B4918_01240 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) B4918_01265 ENOG4105C5H ABC transporter B4918_01280 ENOG4105DEF Extracellular solute-binding protein, family 5 B4918_01290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_01295 ENOG4105C3U ABC transporter B4918_01300 ENOG4108JQ7 (ABC) transporter B4918_01305 ENOG410667J hydrolase B4918_01335 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase B4918_01340 ENOG4105ERH Fumarylacetoacetate hydrolase B4918_01350 ENOG4105CUB amino acid B4918_01355 ENOG4108SC4 )-transporter B4918_01360 ENOG4105CPF Cell wall formation (By similarity) B4918_01365 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B4918_01390 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B4918_01395 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B4918_01405 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B4918_01510 ENOG4105K8N protein family UPF0079, ATPase B4918_01515 ENOG41072GX Peptidase M22 Glycoprotease B4918_01520 ENOG410801F ribosomal-protein-alanine acetyltransferase B4918_01525 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B4918_01535 ENOG4105C5H ABC transporter B4918_01550 ENOG4108TYN CAAX amino terminal protease family protein B4918_01570 ENOG4105C7N Xanthine uracil vitamin C permease B4918_01580 ENOG4105BZU Histidine kinase B4918_01610 ENOG4107ZXU DSBA oxidoreductase B4918_01630 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_01655 ENOG410631K Membrane B4918_01685 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B4918_01690 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B4918_01695 ENOG4105C83 adenylosuccinate lyase B4918_01705 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B4918_01730 ENOG4108V3E phosphoribosylglycinamide formyltransferase B4918_01740 ENOG4105C12 Phosphoribosylglycinamide synthetase B4918_01765 ENOG4105C4R Atp-dependent dna helicase B4918_01790 ENOG4108W2Y isochorismatase B4918_01795 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B4918_01800 ENOG4108UMI ABC transporter, permease B4918_01805 ENOG4105D01 (LipO)protein B4918_01810 ENOG4107I77 yiaA/B two helix domain B4918_01830 ENOG4105CBD Diacylglycerol kinase B4918_01840 ENOG4108JPW Aminotransferase B4918_01850 ENOG4105C26 Dehydrogenase B4918_01855 ENOG4105KPY Small multidrug resistance protein B4918_01880 ENOG4105D9N nucleoside B4918_01885 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B4918_01895 ENOG4108W15 Protein of unknown function (DUF1456) B4918_01915 ENOG4105DTQ mandelate racemase muconate lactonizing B4918_01925 ENOG4105DFD Na H antiporter B4918_01945 ENOG4105D3R alkyl hydroperoxide reductase B4918_01950 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) B4918_01955 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B4918_01960 ENOG4107W7X Aldolase B4918_01965 ENOG4105EHG Permease protein B4918_01970 ENOG4105DQ5 transport system permease protein B4918_01975 ENOG4108V5C ABC transporter B4918_02005 ENOG4106UIA B4918_02010 ENOG4106UIA B4918_02030 ENOG4105BZU Histidine kinase B4918_02050 ENOG410756H nucleotidyltransferase B4918_02055 ENOG4105D2S major facilitator superfamily B4918_02070 ENOG4105E5Q amino acid AbC transporter B4918_02075 ENOG4105EAB amino acid AbC transporter B4918_02080 ENOG4105CDA abc transporter atp-binding protein B4918_02085 ENOG4105C8Q Methyl-accepting chemotaxis B4918_02100 ENOG4105DBV ornithine carbamoyltransferase B4918_02110 ENOG4105C5B carbamate kinase B4918_02115 ENOG4108W63 CRP FNR family transcriptional regulator B4918_02125 ENOG4105DNP FAD linked oxidase domain protein B4918_02135 ENOG4105CI1 PTS System B4918_02150 ENOG4105C9U ATP-dependent DNA helicase RecQ B4918_02165 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter B4918_02185 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B4918_02190 ENOG4105D2X ABC transporter substrate-binding protein B4918_02200 ENOG4105C5H ABC transporter B4918_02235 ENOG41062JF Transcriptional regulator B4918_02250 ENOG4105DEU major facilitator superfamily B4918_02280 ENOG4108N0M stress protein B4918_02285 ENOG4106FN3 tellurium resistance protein B4918_02290 ENOG4106FN3 tellurium resistance protein B4918_02295 ENOG4107TS3 membrane protein, TerC B4918_02300 ENOG4108TTB tellurium resistance protein B4918_02315 ENOG41068PA UPF0435 protein B4918_02320 ENOG4105KJF protein tyrosine phosphatase B4918_02330 ENOG4107U9T Pfam:Ribonuclease_BN B4918_02340 ENOG4105C59 p-type ATPase B4918_02345 ENOG4108IPJ Membrane B4918_02365 ENOG4107ZTW SNARE associated Golgi B4918_02385 ENOG4105UPD Calcium Proton B4918_02420 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B4918_02435 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B4918_02445 ENOG4108JUB Transcriptional regulator B4918_02455 ENOG4108IQI permease B4918_02490 ENOG4105CSV Glutaminase B4918_02510 ENOG4108A04 Beta-lactamase B4918_02525 ENOG4107R51 Glycosyl transferase, family 2 B4918_02530 ENOG4107QQG Dehydrogenase B4918_02535 ENOG4105C3I Nad-dependent epimerase dehydratase B4918_02540 ENOG4105CKK Glycosyl transferase, family 2 B4918_02555 ENOG4105F1A Pyruvate formate-lyase B4918_02575 ENOG4105CI2 imidazolone-5-propionate hydrolase B4918_02580 ENOG4105ECP epimerase B4918_02610 ENOG41067AE Membrane-bound metal-dependent hydrolase B4918_02615 ENOG4105CEN a g-specific adenine glycosylase B4918_02620 ENOG4106BXE B4918_02640 ENOG4105BZ1 (ABC) transporter B4918_02645 ENOG4107NBY Membrane B4918_02650 ENOG4105CBC glutamate synthase B4918_02660 ENOG4108IUW ABC transporter B4918_02680 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_02685 ENOG4105G5W regulator Fur family B4918_02840 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_02875 ENOG4108JQC penicillin-binding protein 1A B4918_02880 ENOG4108R9S DSBA oxidoreductase B4918_02890 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B4918_02900 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B4918_02905 ENOG4105BZU Histidine kinase B4918_02915 ENOG4105CYN Serine protein kinase B4918_02935 ENOG4105C94 Transporter B4918_02950 ENOG4105DZ6 Band 7 protein B4918_02960 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B4918_02965 ENOG4108V9W transcriptional regulatory protein B4918_02970 ENOG4105D4T Citrate transporter B4918_02995 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B4918_03000 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_03005 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B4918_03010 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component B4918_03015 ENOG4105BZ7 extracellular solute-binding protein family 1 B4918_03020 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) B4918_03025 ENOG4108STX response regulator B4918_03030 ENOG4105US7 Histidine kinase B4918_03055 ENOG4108MRH transcriptional regulatory protein B4918_03065 ENOG4105C6K Malic enzyme B4918_03075 ENOG4108UZ3 Transporter B4918_03080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_03090 ENOG4105BZU Histidine kinase B4918_03120 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B4918_03125 ENOG4108JB9 formate dehydrogenase B4918_03145 ENOG4105CUB amino acid B4918_03155 ENOG4105C59 p-type ATPase B4918_03160 ENOG4105DAP Nicotinate phosphoribosyltransferase B4918_03195 ENOG41073R8 VanW family B4918_03200 ENOG4108KGH TRANSCRIPTIONal B4918_03205 ENOG4105D9N nucleoside B4918_03210 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B4918_03215 ENOG41085W3 Transposase B4918_03225 ENOG4105C37 (CBS) domain B4918_03230 ENOG4108IJ0 Aspartate ammonia-lyase B4918_03235 ENOG4105DAA L-lactate B4918_03250 ENOG4105DUX Transporter B4918_03255 ENOG4108MES Periplasmic binding protein B4918_03260 ENOG4105DQ5 transport system permease protein B4918_03265 ENOG4108IHU transport system permease protein B4918_03270 ENOG4105E0A ABC, transporter B4918_03285 ENOG4105EXW epimerase dehydratase B4918_03295 ENOG4107T89 von Willebrand factor, type A B4918_03300 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B4918_03305 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B4918_03315 ENOG4105BZU Histidine kinase B4918_03320 ENOG4105D5Q Arginine ornithine antiporter B4918_03325 ENOG4107414 GntR family transcriptional regulator B4918_03330 ENOG4105C5Y PTS System B4918_03335 ENOG4105CG3 alpha amylase, catalytic region B4918_03350 ENOG4105E1K spore germination protein B4918_03355 ENOG4105CRN Aminoglycoside phosphotransferase B4918_03360 ENOG4105BZG amino acid carrier protein B4918_03370 ENOG4105CDA abc transporter atp-binding protein B4918_03375 ENOG4105CT1 (ABC) transporter B4918_03380 ENOG4105EAD ABC transporter B4918_03385 ENOG4105DRP amino acid AbC transporter B4918_03390 ENOG4108IQI permease B4918_03405 ENOG4105GFR rna polymerase sigma factor B4918_03415 ENOG4105D29 Helix-turn-helix type 11 domain protein B4918_03420 ENOG4105NAE bifunctional deaminase-reductase domain protein B4918_03425 ENOG4105BZU Histidine kinase B4918_03440 ENOG4105CHH sulfate transporter B4918_03445 ENOG41068KF Universal stress protein B4918_03455 ENOG4105CXY transporter B4918_03460 ENOG41067TZ transcriptional regulator, MarR family B4918_03465 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_03470 ENOG4105ETE Transcriptional regulator (LacI family B4918_03475 ENOG4108RVA ribokinase B4918_03485 ENOG4105C2J ABC transporter B4918_03490 ENOG4105CNN ABC, transporter B4918_03495 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B4918_03500 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B4918_03540 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) B4918_03570 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B4918_03575 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B4918_03580 ENOG41069ER domain protein B4918_03585 ENOG4105VZ8 Transcriptional regulator B4918_03590 ENOG4107D63 B4918_03605 ENOG4105DUX Transporter B4918_03625 ENOG4105C85 amino acid B4918_03630 ENOG4105C7N Xanthine uracil vitamin C permease B4918_03645 ENOG4105MA6 gCN5-related N-acetyltransferase B4918_03670 ENOG4105BZ9 Cytochrome C oxidase, subunit I B4918_03675 ENOG4105E2S oxidase) subunit II B4918_03695 ENOG4106CAD Protein of unknown function (DUF3311) B4918_03700 ENOG4105E1V na solute symporter B4918_03715 ENOG4108NHD germination protein B4918_03725 ENOG4105CE1 Ferrous iron transport protein b B4918_03730 ENOG4105CE1 Ferrous iron transport protein b B4918_03735 ENOG4105CE1 Ferrous iron transport protein b B4918_03740 ENOG4105CVA phosphate B4918_03745 ENOG4105C8U phosphate abc transporter B4918_03750 ENOG4105E2Z phosphate ABC transporter (Permease B4918_03880 ENOG41080XQ Signal transduction protein with cbs domains B4918_03905 ENOG4105ETU transcriptional activator (TenA B4918_03915 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component B4918_03925 ENOG4108VEU Thiamine monophosphate synthase B4918_03930 ENOG41080HI glycine oxidase B4918_03945 ENOG4105D06 uba thif-type nad fad binding protein B4918_03950 ENOG4105DWF phosphomethylpyrimidine kinase B4918_03985 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) B4918_04000 ENOG4108INS Transcriptional regulator B4918_04025 ENOG4105C19 ABC transporter B4918_04035 ENOG4105C7N Xanthine uracil vitamin C permease B4918_04045 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein B4918_04060 ENOG4105K63 Thioredoxin B4918_04080 ENOG4108B31 Spore germination protein B4918_04100 ENOG4107Y03 Nitroreductase B4918_04105 ENOG4105ED1 spovr family B4918_04125 ENOG4105XTG Pfam:DUF156 B4918_04130 ENOG4105VFE sira family B4918_04135 ENOG4107TPS domain protein B4918_04140 ENOG4105VFE sira family B4918_04145 ENOG4105VFE sira family B4918_04150 ENOG41085GJ domain protein B4918_04155 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase B4918_04160 ENOG41087NI Sulfite exporter TauE/SafE B4918_04170 ENOG4108KGH TRANSCRIPTIONal B4918_04195 ENOG4105EMD TRANSCRIPTIONal B4918_04200 ENOG4105VCP PTS System B4918_04205 ENOG4105VZJ PTS System B4918_04230 ENOG41069ER domain protein B4918_04235 ENOG4107RBB ABC transporter, permease B4918_04240 ENOG4105C19 ABC transporter B4918_04270 ENOG4105WEF catalase B4918_04305 ENOG4107T5V SNARE associated Golgi B4918_04340 ENOG4105CUB amino acid B4918_04345 ENOG4107RWR Sodium hydrogen exchanger B4918_04355 ENOG4106KNT transcriptional regulator B4918_04395 ENOG4108YXU transcriptional regulator AsnC family B4918_04405 ENOG4105UBK short-chain dehydrogenase reductase B4918_04410 ENOG4105W1Y Transcriptional regulator B4918_04415 ENOG4105KPY Small multidrug resistance protein B4918_04445 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF B4918_04455 ENOG4107RKG DJ-1/PfpI family B4918_04460 ENOG4105CH6 catalase B4918_04470 ENOG4105D5Q Arginine ornithine antiporter B4918_04475 ENOG4105C26 Dehydrogenase B4918_04490 ENOG4105BZ1 (ABC) transporter B4918_04495 ENOG4105BZ1 (ABC) transporter B4918_04510 ENOG4105DRP amino acid AbC transporter B4918_04515 ENOG4105CDA abc transporter atp-binding protein B4918_04530 ENOG410839P B4918_04565 ENOG4107FQX Alpha-acetolactate decarboxylase B4918_04585 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_04590 ENOG4105D4P Coproporphyrinogen iii oxidase B4918_04595 ENOG4105CEY Amp-dependent synthetase and ligase B4918_04605 ENOG4105CHH sulfate transporter B4918_04630 ENOG4105CGU Enoyl-CoA hydratase B4918_04650 ENOG4105DER m42 family B4918_04670 ENOG4105CTU Proline racemase B4918_04675 ENOG4105CIF Ornithine Cyclodeaminase B4918_04690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_04700 ENOG4108JQ7 (ABC) transporter B4918_04750 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase B4918_04765 ENOG4105D06 uba thif-type nad fad binding protein B4918_04770 ENOG4107SFI Major Facilitator superfamily B4918_04805 ENOG4105DQ6 Transposase B4918_04810 ENOG4105CSH Transporter B4918_04820 ENOG4108MRH transcriptional regulatory protein B4918_04860 ENOG4105CVR type I restriction-modification system B4918_04865 ENOG4107XZC Restriction modification system DNA (Specificity B4918_04870 ENOG4105DZR Type I site-specific deoxyribonuclease B4918_04880 ENOG4105C4R Atp-dependent dna helicase B4918_04885 ENOG4105C4R Atp-dependent dna helicase B4918_04905 ENOG4105EB3 Histidine kinase B4918_04920 ENOG4105DVF Cytosine-specific methyltransferase B4918_04930 ENOG4105CDU Replicative dna helicase B4918_04960 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_04980 ENOG4105D9U N-acetyltransferase B4918_05000 ENOG4105DQ6 Transposase B4918_05030 ENOG4105F6J Alpha beta hydrolase fold B4918_05100 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B4918_05110 ENOG4105F27 Major Facilitator B4918_05115 ENOG4105WAB arsR family transcriptional regulator B4918_05130 ENOG4105CMT Dihydroxyacetone kinase B4918_05140 ENOG4105CMT Dihydroxyacetone kinase B4918_05245 ENOG4105WN5 stage II sporulation protein B4918_05255 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_05265 ENOG4108MJI response regulator B4918_05270 ENOG4105BZU Histidine kinase B4918_05275 ENOG4105BZU Histidine kinase B4918_05310 ENOG4105D7V transposase B4918_05320 ENOG4107QHE Choloylglycine hydrolase B4918_05340 ENOG4107VRP DNA repair exonuclease B4918_05345 ENOG4106D4I domain protein B4918_05365 ENOG410829K Lysine exporter protein (Lyse ygga) B4918_05390 ENOG4108MUZ hydrolase B4918_05405 ENOG4105F0F Oxalate decarboxylase B4918_05410 ENOG41067QW Transcriptional regulator B4918_05415 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B4918_05430 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B4918_05440 ENOG4105EMN RNA polymerase sigma factor B4918_05455 ENOG4105EEM helicase B4918_05460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_05490 ENOG4105K59 histidine triad (HIT) protein B4918_05525 ENOG410905X membrane-flanked domain protein B4918_05530 ENOG4105CKV Membrane B4918_05570 ENOG410905X membrane-flanked domain protein B4918_05575 ENOG4105CKV Membrane B4918_05580 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B4918_05585 ENOG4105BZ4 penicillin-binding protein B4918_05595 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B4918_05600 ENOG4105C1Q protoporphyrinogen oxidase B4918_05630 ENOG4105ECB domain protein B4918_05660 ENOG4106AXD B4918_05665 ENOG4108RQ5 Beta-lactamase domain-containing protein B4918_05670 ENOG4105DF9 Lipoate-protein, ligase B4918_05680 ENOG4105CEY Amp-dependent synthetase and ligase B4918_05710 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) B4918_05720 ENOG4105ENX hydrolase B4918_05725 ENOG4107RN3 metallophosphoesterase B4918_05730 ENOG4107TVP HD domain protein B4918_05745 ENOG4108AEY RNA polymerase sigma factor B4918_05750 ENOG41086D8 Transcriptional regulator B4918_05770 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_05790 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B4918_05795 ENOG4105C8Q Methyl-accepting chemotaxis B4918_05805 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) B4918_05815 ENOG4107QP3 malate synthase g B4918_05835 ENOG4105VEQ Cold shock protein B4918_05850 ENOG4105XVF Competence transcription factor B4918_05915 ENOG4105ERH Fumarylacetoacetate hydrolase B4918_05925 ENOG4105C8Y Acetylornithine aminotransferase B4918_05940 ENOG4105CAQ asparagine synthetase B4918_05955 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B4918_06160 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_06185 ENOG4105CAQ asparagine synthetase B4918_06190 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B4918_06195 ENOG4105CH6 catalase B4918_06200 ENOG4105BZU Histidine kinase B4918_06220 ENOG4105QNR S1 RNA binding domain protein B4918_06225 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_06235 ENOG4107AYK membrAne B4918_06240 ENOG41073B9 B4918_06250 ENOG4108KP7 hydrolase B4918_06265 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit B4918_06290 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B4918_06295 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B4918_06315 ENOG4105C31 Tryptophanyl-tRNA synthetase B4918_06335 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B4918_06340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_06350 ENOG4108JQ7 (ABC) transporter B4918_06355 ENOG4105UQX Mate efflux family protein B4918_06385 ENOG4108ZCF integral membrane protein B4918_06395 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B4918_06405 ENOG4105DPN Oligoendopeptidase f B4918_06420 ENOG4108Z18 K06886 hemoglobin B4918_06425 ENOG4105MIX Adenylate cyclase B4918_06440 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B4918_06445 ENOG4105EMS pseudouridine synthase B4918_06465 ENOG4105K64 Glycosyl transferase, family 2 B4918_06485 ENOG4107TVC Glycosyl transferase, family 2 B4918_06505 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) B4918_06510 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase B4918_06520 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase B4918_06595 ENOG4105CK7 Sodium proline symporter B4918_06605 ENOG4105CRQ synthase (Component I) B4918_06610 ENOG4105DDQ anthranilate synthase B4918_06715 ENOG4105C7S Dehydrogenase B4918_06720 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 B4918_06725 ENOG4105VZ8 Transcriptional regulator B4918_06770 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) B4918_06780 ENOG4105DZ1 carboxypeptidase B4918_06785 ENOG4105VFR signal peptidase B4918_06815 ENOG4105C26 Dehydrogenase B4918_06820 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_06825 ENOG4105F38 ABC transporter, permease B4918_06830 ENOG4105D38 putrescine abc transporter B4918_06835 ENOG4107RUE extracellular solute-binding protein family 1 B4918_06840 ENOG410841Q phosphoesterase PA-phosphatase related protein B4918_06845 ENOG4105EYF MMPL domain protein B4918_06855 ENOG4108YBP pseudouridine synthase B4918_06865 ENOG4105K4I Scp-like extracellular B4918_06870 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B4918_06875 ENOG4105CQB FAD linked oxidase domain protein B4918_06890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_06895 ENOG4105BZU Histidine kinase B4918_06900 ENOG4105JXH GntR family transcriptional regulator B4918_06920 ENOG4106A3R peptidase B4918_06930 ENOG4108QTI )-transporter B4918_06935 ENOG4107TS3 membrane protein, TerC B4918_06940 ENOG4105CZN Potassium uptake protein B4918_06945 ENOG410681C small acid-soluble spore protein B4918_06950 ENOG4108Z7G MaoC domain protein dehydratase B4918_06970 ENOG4105CHR reductase B4918_07005 ENOG4105C4Y ABC transporter B4918_07010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_07015 ENOG4107RCV ABC transporter, permease B4918_07035 ENOG4105E98 transcriptional regulator DeoR family B4918_07050 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) B4918_07060 ENOG4105PXI polysaccharide deacetylase B4918_07070 ENOG4105BZU Histidine kinase B4918_07075 ENOG41090MY MarR family Transcriptional regulator B4918_07085 ENOG4106DF1 B4918_07095 ENOG4105BZU Histidine kinase B4918_07105 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase B4918_07110 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B4918_07160 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B4918_07165 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B4918_07170 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B4918_07175 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B4918_07180 ENOG4105CZV ABC transporter B4918_07190 ENOG4105CJ1 ABC, transporter B4918_07230 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B4918_07235 ENOG4105EA8 2-Nitropropane dioxygenase B4918_07240 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B4918_07250 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B4918_07275 ENOG4105NQC Flavodoxin B4918_07320 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B4918_07350 ENOG4105CZN Potassium uptake protein B4918_07355 ENOG41063Y9 B4918_07360 ENOG4105KBJ sporulation protein ytfj B4918_07390 ENOG4105CM2 brancheD-chain amino acid aminotransferase B4918_07395 ENOG4105C7K acetolactate synthase B4918_07400 ENOG4108ZP8 Acetolactate synthase small subunit B4918_07405 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B4918_07440 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B4918_07475 ENOG4107RVV histidinol phosphate phosphatase, hisj family B4918_07490 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B4918_07495 ENOG4105E0M Sulfatase B4918_07500 ENOG4105VTR Integrase B4918_07515 ENOG4108IMY Transcriptional regulator B4918_07525 ENOG4108ZUE Phage regulatory protein rha B4918_07570 ENOG4105KRN Transcriptional regulator, abrb family B4918_07710 ENOG4105CAR Terminase, large subunit B4918_07720 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B4918_07790 ENOG4105XSJ toxin secretion phage lysis holin B4918_07795 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B4918_07815 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B4918_07835 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) B4918_07840 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B4918_07850 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B4918_07855 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B4918_07860 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B4918_07870 ENOG4105C8J )-transporter B4918_07890 ENOG4105DFD Na H antiporter B4918_07910 ENOG4105ENE Histidine kinase B4918_07915 ENOG4105WH1 Two component transcriptional regulator luxr family B4918_07935 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B4918_07960 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B4918_07985 ENOG4105CJ3 phosphate transporter B4918_07990 ENOG4107GRR phosphate transport regulator B4918_07995 ENOG4105BZ4 penicillin-binding protein B4918_08010 ENOG4105BZU Histidine kinase B4918_08015 ENOG4105I3N Conserved Protein B4918_08030 ENOG4105BZU Histidine kinase B4918_08060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B4918_08065 ENOG4105DZ1 carboxypeptidase B4918_08070 ENOG4108JIC nucleoside recognition domain protein B4918_08080 ENOG4105FE9 pseudouridine synthase B4918_08085 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_08090 ENOG4107TWT Cytochrome c biogenesis protein B4918_08095 ENOG4105CRE cytochrome C B4918_08100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_08105 ENOG4105BZU Histidine kinase B4918_08110 ENOG4108WBT adenosyltransferase B4918_08125 ENOG4108SAX Membrane B4918_08140 ENOG4105C9U ATP-dependent DNA helicase RecQ B4918_08145 ENOG4105I7S Abortive infection protein B4918_08155 ENOG4107RGJ metallophosphoesterase B4918_08160 ENOG4108XDN Transcriptional regulator B4918_08165 ENOG4108S6Z Negative regulator of genetic competence B4918_08190 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B4918_08195 ENOG4107RB3 L-asparaginase B4918_08230 ENOG4105S2F B4918_08235 ENOG41065D1 B4918_08265 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B4918_08280 ENOG4105XXQ heptaprenyl diphosphate synthase component I B4918_08290 ENOG4105EAH synthase B4918_08295 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B4918_08300 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B4918_08320 ENOG41068YB TPR repeat-containing protein B4918_08335 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) B4918_08340 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B4918_08375 ENOG4108JYZ YitT family B4918_08380 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B4918_08395 ENOG4105FJR Lmbe family B4918_08400 ENOG4105CPK Glycosyl transferase (Group 1 B4918_08440 ENOG4105DVT helicase B4918_08445 ENOG4105YAC B4918_08465 ENOG4105CSM endonuclease III B4918_08475 ENOG4105BZ4 penicillin-binding protein B4918_08535 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B4918_08545 ENOG4105DVT helicase B4918_08550 ENOG4105CTD carboxy-peptidase B4918_08565 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B4918_08575 ENOG4105C2W permease B4918_08580 ENOG4105DHF Membrane B4918_08590 ENOG410890F Dynamin family B4918_08600 ENOG4108W0I acetyltransferase B4918_08610 ENOG4105KHC sulfurtransferase B4918_08635 ENOG4106032 Glutathionylspermidine synthase B4918_08695 ENOG4105CPK Glycosyl transferase (Group 1 B4918_08710 ENOG4108SZE gCN5-related N-acetyltransferase B4918_08730 ENOG41081VK Ribonuclease B4918_08795 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B4918_08805 ENOG4107RWR Sodium hydrogen exchanger B4918_08810 ENOG4105CN5 Metallo-Beta-Lactamase B4918_08815 ENOG4108Z5V transcriptional regulator, merr family B4918_08825 ENOG4105H67 Protein of unknown function (DUF421) B4918_08830 ENOG41080C8 DUF218 domain B4918_08865 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B4918_08875 ENOG4107R0U MotA TolQ exbB proton channel B4918_08880 ENOG4105ER2 Ompa motb domain protein B4918_08885 ENOG4107YTP response regulator receiver protein B4918_08890 ENOG4105CBS Chea signal transduction histidine kinase B4918_08895 ENOG4105DD5 Flagellar motor switch protein B4918_08910 ENOG4105BZU Histidine kinase B4918_08930 ENOG4105E1Q flagellar hook-associated protein B4918_08935 ENOG4105DTJ flagellar hook-associated protein B4918_08940 ENOG4105DTS flagellar hook-associated B4918_08960 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B4918_08965 ENOG4108ZC9 flagellar basal-body rod protein flgc B4918_08970 ENOG41075Z6 flagellar hook-basal body complex protein fliE B4918_08975 ENOG4107U2N Flagellar M-ring protein B4918_08980 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B4918_09010 ENOG4105BZE flagellar hook protein, FlgE B4918_09025 ENOG4107R88 Chemotaxis protein (CheV) B4918_09035 ENOG4105I03 Flagellin B4918_09040 ENOG4105I03 Flagellin B4918_09045 ENOG4105E4C Lytic transglycosylase catalytic B4918_09055 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B4918_09060 ENOG4105DD5 Flagellar motor switch protein B4918_09070 ENOG4105CN7 Flagellar biosynthetic protein FliP B4918_09075 ENOG4105VS8 Flagellar biosynthetic protein fliq B4918_09085 ENOG4105D00 flagellar biosynthetic protein flhB B4918_09090 ENOG4105D7B Flagellar biosynthesis protein flha B4918_09095 ENOG4105FZW flagellar biosynthesis regulator FlhF B4918_09100 ENOG4105KTQ flagellar basal-body rod protein B4918_09105 ENOG4105CPU Monooxygenase B4918_09110 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B4918_09140 ENOG4105KAC Antibiotic biosynthesis monooxygenase B4918_09145 ENOG4107QZ7 Cellulose synthase catalytic subunit B4918_09170 ENOG4105DUM transcriptional regulator, lysR family B4918_09175 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) B4918_09185 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component B4918_09225 ENOG4105CVJ phosphoglycerate mutase B4918_09240 ENOG4105K56 Transcriptional regulator B4918_09250 ENOG4105CAQ asparagine synthetase B4918_09270 ENOG4105PGM cation diffusion facilitator family transporter B4918_09285 ENOG4105CKI cobalamin synthesis protein B4918_09295 ENOG4108PJD permease B4918_09310 ENOG4105DFD Na H antiporter B4918_09315 ENOG4105VUF Transcriptional regulator B4918_09325 ENOG4105C9Q fumarate hydratase class II B4918_09345 ENOG4107QJQ Mate efflux family protein B4918_09350 ENOG4105EC3 peptidase S51, dipeptidase E B4918_09370 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_09540 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_09575 ENOG4105K63 Thioredoxin B4918_09600 ENOG4105C2M dna polymerase I B4918_09660 ENOG4106BRA Membrane B4918_09700 ENOG4105CJ1 ABC, transporter B4918_09720 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) B4918_09730 ENOG4108IJ0 Aspartate ammonia-lyase B4918_09735 ENOG4105C6K Malic enzyme B4918_09800 ENOG4105FVX B4918_09805 ENOG4105E09 nadh pyrophosphatase B4918_09820 ENOG4105CSR polyphosphate kinase 2 B4918_09825 ENOG4105U3E Transcriptional regulator B4918_09835 ENOG4105DXI Major Facilitator superfamily B4918_09845 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B4918_09850 ENOG4105EU0 Major facilitator Superfamily B4918_09855 ENOG4105C6T cysteine synthase B4918_09875 ENOG4105C8J )-transporter B4918_09885 ENOG4105X5K response regulator receiver protein B4918_09890 ENOG4105H67 Protein of unknown function (DUF421) B4918_09920 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) B4918_09925 ENOG4105CHR reductase B4918_09930 ENOG4105CM2 brancheD-chain amino acid aminotransferase B4918_09935 ENOG4105C7K acetolactate synthase B4918_09945 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B4918_09955 ENOG4105C7B Threonine dehydratase B4918_09980 ENOG4105C6X Major Facilitator B4918_09985 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b B4918_10000 ENOG4105DY9 regulatoR B4918_10005 ENOG4105CYC Transferase B4918_10030 ENOG41068WN B4918_10050 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B4918_10065 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) B4918_10070 ENOG4105C0X amino acid B4918_10110 ENOG410849A acetyltransferase, (GNAT) family B4918_10120 ENOG4105K8R UPF0145 protein B4918_10135 ENOG4107RHR regulatoR B4918_10145 ENOG4105D9N nucleoside B4918_10150 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B4918_10155 ENOG4105KG3 cytidine deaminase B4918_10170 ENOG4105DQ6 Transposase B4918_10185 ENOG4108IBT Inherit from COG: transposase B4918_10210 ENOG4107RAQ aminopeptidase B4918_10255 ENOG4105JVQ RNA Polymerase B4918_10260 ENOG4107VMI polysaccharide deacetylase B4918_10285 ENOG4105CJW magnesium transporter B4918_10290 ENOG4105CNI cell division protein FtsW B4918_10335 ENOG4108IMY Transcriptional regulator B4918_10360 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_10385 ENOG4105E1K spore germination protein B4918_10390 ENOG4107TVC Glycosyl transferase, family 2 B4918_10440 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic B4918_10495 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_10500 ENOG410847I Transcriptional regulator, BadM Rrf2 family B4918_10510 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) B4918_10540 ENOG4105EKQ RNA-directed DNA polymerase B4918_10620 ENOG4108T5E Copper resistance protein B4918_10625 ENOG4105KTB nuclear export factor GLE1 B4918_10630 ENOG4107RT3 EamA-like transporter family B4918_10635 ENOG4105GZI Transcriptional regulator B4918_10640 ENOG4108Z40 Transcriptional regulator B4918_10645 ENOG4107ZXU DSBA oxidoreductase B4918_10650 ENOG4108TVJ Nitroreductase B4918_10695 ENOG41085W3 Transposase B4918_10770 ENOG4105C2M dna polymerase I B4918_10860 ENOG4105KRN Transcriptional regulator, abrb family B4918_11075 ENOG4106F5Q Membrane B4918_11080 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B4918_11095 ENOG4105CKI cobalamin synthesis protein B4918_11105 ENOG4105C0Z ABC transporter B4918_11110 ENOG4108IV0 ABC, transporter B4918_11115 ENOG4105C32 Amino acid ABC transporter (Permease) B4918_11125 ENOG4105EGI Transcriptional regulator B4918_11135 ENOG4105MDS 4-oxalocrotonate tautomerase B4918_11155 ENOG4105C4M (Ubiquinol oxidase) subunit I B4918_11160 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B4918_11165 ENOG4108JJ9 ABC, transporter B4918_11170 ENOG4108JJ8 (ABC) transporter B4918_11180 ENOG4105K64 Glycosyl transferase, family 2 B4918_11190 ENOG4108UT6 Transferase hexapeptide repeat containing protein B4918_11245 ENOG4105BZ1 (ABC) transporter B4918_11250 ENOG4105EFI regulatoR B4918_11255 ENOG4105BZU Histidine kinase B4918_11265 ENOG4108VQJ O-methyltransferase B4918_11275 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B4918_11280 ENOG4108ZJ4 polysaccharide deacetylase B4918_11300 ENOG4105D6E homoserine dehydrogenase B4918_11325 ENOG4108KGH TRANSCRIPTIONal B4918_11345 ENOG4105KT7 mgtC SapB transporter B4918_11350 ENOG4105VRR gCN5-related N-acetyltransferase B4918_11360 ENOG4105DUU IucA IucC family protein B4918_11365 ENOG4105CEY Amp-dependent synthetase and ligase B4918_11380 ENOG4108WBH protein TIM barrel B4918_11385 ENOG4105YWU small acid-soluble spore protein B4918_11395 ENOG4108ZUB Lysine exporter protein (Lyse ygga) B4918_11400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_11415 ENOG4105EKQ RNA-directed DNA polymerase B4918_11465 ENOG4105KRN Transcriptional regulator, abrb family B4918_11475 ENOG4105YVS arsR family transcriptional regulator B4918_11480 ENOG4105CPC Aldo Keto reductase B4918_11485 ENOG4107XZQ multidrug resistance protein B4918_11515 ENOG4105C8Q Methyl-accepting chemotaxis B4918_11535 ENOG4108K88 Membrane B4918_11540 ENOG4108WPJ Ferritin-like domain B4918_11555 ENOG4105DEN Luciferase family B4918_11570 ENOG4105VMI -acetyltransferase B4918_11575 ENOG4107QM2 Aldo Keto reductase B4918_11580 ENOG4105CKI cobalamin synthesis protein B4918_11590 ENOG4105DSE periplasmic solute binding protein B4918_11600 ENOG4105K4T epimerase B4918_11610 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B4918_11635 ENOG4105CVJ phosphoglycerate mutase B4918_11655 ENOG4107T5V SNARE associated Golgi B4918_11670 ENOG4108PJD permease B4918_11680 ENOG4108S4H thioesterase Superfamily protein B4918_11690 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B4918_11710 ENOG4105SXS Protein of unknown function (DUF456) B4918_11715 ENOG4105C37 (CBS) domain B4918_11745 ENOG4108Z7R Chaperone CsaA B4918_11765 ENOG4108ZRV stage ii sporulation protein p B4918_11775 ENOG4108VXD carboxy-peptidase B4918_11785 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B4918_11815 ENOG4108X4Q Hydrolase B4918_11820 ENOG41082F9 transcriptional regulator B4918_11825 ENOG4105D94 Major Facilitator Superfamily B4918_11835 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B4918_11840 ENOG4107RBS Methyltransferase B4918_11855 ENOG41087PP glycosyltransferase MGT family B4918_11860 ENOG4108JYZ YitT family B4918_11865 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_11895 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) B4918_11915 ENOG4106PAW secretion accessory protein EsaA YueB B4918_11925 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) B4918_12000 ENOG4105KBJ sporulation protein ytfj B4918_12025 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B4918_12045 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) B4918_12050 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily B4918_12060 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein B4918_12085 ENOG4105CNW domain protein B4918_12095 ENOG4108V06 Glutathione peroxidase B4918_12110 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B4918_12120 ENOG4108IUE nitrate reductase beta subunit B4918_12125 ENOG4105R3A Nitrate reductase B4918_12135 ENOG4107V6Q Cyclic nucleotide-binding domain B4918_12140 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B4918_12145 ENOG4105D06 uba thif-type nad fad binding protein B4918_12150 ENOG4105CVM Molybdenum cofactor synthesis domain protein B4918_12155 ENOG4108ZAF Molybdopterin B4918_12185 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B4918_12190 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B4918_12195 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B4918_12200 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B4918_12205 ENOG4108IFG nitrite reductase, (NAD(P)H) B4918_12210 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) B4918_12245 ENOG4105MCT stage V sporulation protein S B4918_12265 ENOG4105DQ6 Transposase B4918_12295 ENOG4105C5H ABC transporter B4918_12310 ENOG4108UUM single-stranded DNA-binding protein B4918_12335 ENOG4107YX5 Pfam:DUF548 B4918_12340 ENOG4105C75 arginyL-tRNA synthetase B4918_12385 ENOG4105C5S asparaginyl-tRNA synthetase B4918_12390 ENOG4105C8J )-transporter B4918_12395 ENOG4108EF6 Proline imino-peptidase B4918_12410 ENOG4107XGZ Hydrolase B4918_12415 ENOG4105CY2 Citrate transporter B4918_12435 ENOG4105KD7 acetyltransferase B4918_12445 ENOG4105VMP Transcriptional regulator B4918_12450 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase B4918_12475 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 B4918_12505 ENOG4107RVG penicillin-binding protein B4918_12515 ENOG4105E9Q Acyl-transferase B4918_12520 ENOG4108UT2 hemolysin iii B4918_12530 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B4918_12540 ENOG4108RCR degv family B4918_12550 ENOG4108KF3 Electron transport protein SCO1 SenC B4918_12555 ENOG4107Y70 Heat shock protein B4918_12560 ENOG4105CAQ asparagine synthetase B4918_12575 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B4918_12580 ENOG4108MES Periplasmic binding protein B4918_12585 ENOG4105F0I Aminotransferase B4918_12615 ENOG4105D8X mechanosensitive ion channel B4918_12620 ENOG4105BZU Histidine kinase B4918_12625 ENOG4105WH1 Two component transcriptional regulator luxr family B4918_12630 ENOG4106KNT transcriptional regulator B4918_12635 ENOG4107ZY0 Phenazine biosynthesis-like protein B4918_12655 ENOG4105CMG Carbohydrate kinase B4918_12660 ENOG4105CMG Carbohydrate kinase B4918_12665 ENOG4105C6Z Gluconate B4918_12675 ENOG4108YV3 Protein of unknown function (DUF2711) B4918_12710 ENOG4105E90 ABC transporter B4918_12745 ENOG4105C37 (CBS) domain B4918_12775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B4918_12790 ENOG4107S4Y M20 DapE family protein YgeY B4918_12795 ENOG4108TSC N-acetyltransferase B4918_12800 ENOG4108JUB Transcriptional regulator B4918_12805 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B4918_12850 ENOG410841Q phosphoesterase PA-phosphatase related protein B4918_12860 ENOG4105SZ6 Thioredoxin B4918_12905 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_12960 ENOG4105BZ4 penicillin-binding protein B4918_12970 ENOG4105CZM Major Facilitator B4918_12975 ENOG4105W8X HesB YadR YfhF-family protein B4918_12985 ENOG4105DXD 2-methylcitrate dehydratase B4918_12990 ENOG4105CR4 methylisocitrate lyase B4918_12995 ENOG4105C1G acyl-Coa dehydrogenase B4918_13000 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B4918_13010 ENOG4105N14 lysine exporter protein LysE YggA B4918_13015 ENOG4105E39 Enoyl-CoA hydratase B4918_13030 ENOG4107RFY SbcCD D subunit B4918_13035 ENOG4105EYH Exonuclease B4918_13060 ENOG4105FCD Major Facilitator B4918_13070 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B4918_13075 ENOG4105E4F Isochorismate synthase B4918_13080 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B4918_13085 ENOG4105WQI isochorismatase B4918_13090 ENOG4105CEY Amp-dependent synthetase and ligase B4918_13095 ENOG4105WQT MbtH domain protein B4918_13100 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_13115 ENOG4105K70 DNA-binding protein B4918_13135 ENOG4105BZG amino acid carrier protein B4918_13155 ENOG4105FE9 pseudouridine synthase B4918_13160 ENOG4105C22 threonyL-tRNA synthetase B4918_13165 ENOG4105C19 ABC transporter B4918_13200 ENOG41081I9 integral membrane protein B4918_13210 ENOG4108Y4K DNA-binding transcriptional activator B4918_13225 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) B4918_13235 ENOG4105EYF MMPL domain protein B4918_13260 ENOG4105WCN acetyltransferase B4918_13285 ENOG4105C1Q protoporphyrinogen oxidase B4918_13295 ENOG41068WN B4918_13325 ENOG4107V2S Transcriptional regulator B4918_13330 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B4918_13340 ENOG4105DND Transcriptional regulator B4918_13345 ENOG4108RPX mosc domain containing protein B4918_13360 ENOG4105BZ1 (ABC) transporter B4918_13365 ENOG4105BZ1 (ABC) transporter B4918_13395 ENOG4108JCI Transcriptional regulator B4918_13425 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) B4918_13430 ENOG4108KPJ rna polymerase sigma factor B4918_13455 ENOG4105F32 YngK protein B4918_13480 ENOG4105RD7 BadF BadG BcrA BcrD B4918_13485 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B4918_13490 ENOG4107STF Involved in phosphonate degradation (By similarity) B4918_13495 ENOG4105C7B Threonine dehydratase B4918_13500 ENOG4108INS Transcriptional regulator B4918_13515 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) B4918_13525 ENOG4105C1J atp-dependent rna helicase B4918_13530 ENOG41088CC tellurite resistance protein tehB B4918_13545 ENOG4107RA9 decarboxylase B4918_13590 ENOG4105CIN aminoacyl-histidine dipeptidase B4918_13615 ENOG4105KRN Transcriptional regulator, abrb family B4918_13625 ENOG4105EJ9 Membrane B4918_13670 ENOG4105W8Z 4'-phosphopantetheinyl transferase B4918_13680 ENOG4105CHR reductase B4918_13740 ENOG4105EKQ RNA-directed DNA polymerase B4918_13755 ENOG4108W0I acetyltransferase B4918_13760 ENOG4107QQG Dehydrogenase B4918_13765 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_13770 ENOG4108IAJ Nad-dependent epimerase dehydratase B4918_13775 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_13790 ENOG4105FJR Lmbe family B4918_13800 ENOG4105IIU Aminopeptidase B4918_13805 ENOG4108SC4 )-transporter B4918_13855 ENOG4108IMY Transcriptional regulator B4918_13870 ENOG4107VMI polysaccharide deacetylase B4918_13915 ENOG41085W3 Transposase B4918_13930 ENOG4107RVG penicillin-binding protein B4918_13945 ENOG4107RF6 penicillin-binding protein B4918_13950 ENOG4107RF6 penicillin-binding protein B4918_13960 ENOG4105DIN metallophosphoesterase B4918_13970 ENOG4105CJ1 ABC, transporter B4918_13980 ENOG4107Z3H Transcriptional regulator, TetR family B4918_13995 ENOG4105C1G acyl-Coa dehydrogenase B4918_14000 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B4918_14005 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B4918_14010 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B4918_14015 ENOG4105E39 Enoyl-CoA hydratase B4918_14020 ENOG4107QX3 carboxylase B4918_14025 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B4918_14035 ENOG41085W3 Transposase B4918_14060 ENOG4105DZ1 carboxypeptidase B4918_14075 ENOG4105T9C HD domain B4918_14090 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B4918_14110 ENOG41075H3 AraC family transcriptional regulator B4918_14140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B4918_14150 ENOG4105CHR reductase B4918_14155 ENOG4105KVH Transcriptional regulator B4918_14225 ENOG410900G Protein of unknown function (DUF421) B4918_14235 ENOG4108V4B ThiJ pfpI B4918_14245 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein B4918_14255 ENOG4105DK7 lysyl-tRNA synthetase B4918_14280 ENOG4106NZI LysR family Transcriptional regulator B4918_14285 ENOG4105CPC Aldo Keto reductase B4918_14330 ENOG4105D6E homoserine dehydrogenase B4918_14340 ENOG4105CPF Cell wall formation (By similarity) B4918_14345 ENOG4105ETU transcriptional activator (TenA B4918_14440 ENOG410667J hydrolase B4918_14445 ENOG4105BZU Histidine kinase B4918_14450 ENOG4107RF6 penicillin-binding protein B4918_14475 ENOG4108FPN Integrase B4918_14505 ENOG41080TC multidrug resistance protein B4918_14540 ENOG4105BZU Histidine kinase B4918_14560 ENOG4105CVP deoxyribo-dipyrimidine photolyase B4918_14590 ENOG4108B31 Spore germination protein B4918_14610 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein B4918_14630 ENOG4105WG9 Conserved Protein B4918_14635 ENOG4105E1K spore germination protein B4918_14690 ENOG4105DU0 nucleoside hydrolase B4918_14750 ENOG4105XZV Protein of unknown function (DUF3243) B4918_14760 ENOG4105F6S Spore photoproduct lyase B4918_14785 ENOG4108JJB ABC transporter B4918_14800 ENOG4108HGU Histidine kinase B4918_14895 ENOG4105CB2 alcohol dehydrogenase B4918_14900 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B4918_14905 ENOG4105CJN penicillin-binding protein B4918_14955 ENOG4105D13 transposase B4918_14995 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B4918_15020 ENOG4107Y9U Membrane B4918_15040 ENOG4105EGD dinuclear metal center protein, YbgI family B4918_15045 ENOG4105M6F mutator MutT protein B4918_15080 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B4918_15085 ENOG4108Z4K mutator MutT protein B4918_15110 ENOG4108XI2 Domain of unknown function (DUF1963) B4918_15140 ENOG4108NRW Phospholipase, patatin family B4918_15145 ENOG4105KWG Pfam:DUF1696 B4918_15170 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B4918_15180 ENOG4105PKS Excinuclease abc c subunit domain protein B4918_15215 ENOG41087PP glycosyltransferase MGT family B4918_15235 ENOG4107VFR oxidoreductase B4918_15260 ENOG4105U0R haloacid dehalogenase-like hydrolase B4918_15265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_15270 ENOG4105BZU Histidine kinase B4918_15290 ENOG4107WD8 ABC transporter, permease B4918_15305 ENOG4105DY8 decarboxylase B4918_15320 ENOG4108IUM Glycogen debranching enzyme B4918_15330 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic B4918_15350 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) B4918_15355 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B4918_15360 ENOG4105FDR Membrane B4918_15365 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B4918_15415 ENOG4105MSI germination protein ypeb B4918_15445 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) B4918_15450 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) B4918_15455 ENOG4107Z3H Transcriptional regulator, TetR family B4918_15475 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B4918_15495 ENOG4105E98 transcriptional regulator DeoR family B4918_15510 ENOG41062ES Transcriptional regulator B4918_15530 ENOG4107QKR Dehydrogenase B4918_15540 ENOG4107RUY (E1 component), alpha subunit B4918_15550 ENOG4105E1F short-chain dehydrogenase reductase B4918_15580 ENOG4107SQ8 Glycine betaine B4918_15585 ENOG4108IJ7 Glycine betaine B4918_15595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B4918_15610 ENOG4105E66 phosphoriboisomerase A B4918_15615 ENOG41082BV acetyltransferase B4918_15635 ENOG4108M1A Chitin-binding protein B4918_15640 ENOG41087PP glycosyltransferase MGT family B4918_15650 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B4918_15665 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B4918_15670 ENOG4105MSB protein, conserved in bacteria B4918_15695 ENOG4108Z7F N-acetyltransferase B4918_15720 ENOG4105KEG ribosomal-protein-alanine acetyltransferase B4918_15725 ENOG4105EEM helicase B4918_15740 ENOG4105C9U ATP-dependent DNA helicase RecQ B4918_15795 ENOG4108M1A Chitin-binding protein B4918_15815 ENOG4105BZG amino acid carrier protein B4918_15820 ENOG4105C26 Dehydrogenase B4918_15825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B4918_15835 ENOG4105CTU Proline racemase B4918_15840 ENOG41080HI glycine oxidase B4918_15850 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein B4918_15880 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B4918_15885 ENOG4105DCI Phosphohydrolase B4918_15890 ENOG4107T5V SNARE associated Golgi B4918_15900 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B4918_15915 ENOG4105DTQ mandelate racemase muconate lactonizing B4918_15930 ENOG4107SET aldo keto reductase B4918_15970 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B4918_15975 ENOG4105BZU Histidine kinase B4918_15980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_16005 ENOG4105DPN Oligoendopeptidase f B4918_16010 ENOG4105EPR degv family B4918_16070 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) B4918_16125 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_16140 ENOG41085W3 Transposase B4918_16215 ENOG4105CAR Terminase, large subunit B4918_16300 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_16325 ENOG4108ZUE Phage regulatory protein rha B4918_16375 ENOG4107BMA Transglycosylase associated protein B4918_16390 ENOG41089UC methyltransferase, type 11 B4918_16430 ENOG4105CHM Aminotransferase B4918_16445 ENOG4108ZMI UPF0477 protein B4918_16460 ENOG4105DVE abc transporter atp-binding protein B4918_16510 ENOG4105C02 permease B4918_16530 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B4918_16535 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B4918_16540 ENOG4105D7T ABC transporter B4918_16565 ENOG4108AQF aminoglycoside N(3)-acetyltransferase B4918_16600 ENOG4107VC0 DNA alkylation repair enzyme B4918_16605 ENOG4105C6T cysteine synthase B4918_16610 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_16630 ENOG4107VMI polysaccharide deacetylase B4918_16650 ENOG4108ZCF integral membrane protein B4918_16655 ENOG4105E0M Sulfatase B4918_16660 ENOG4105C5H ABC transporter B4918_16665 ENOG4105EYF MMPL domain protein B4918_16670 ENOG41082JN Transcriptional regulator B4918_16695 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B4918_16705 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B4918_16740 ENOG41069ER domain protein B4918_16770 ENOG4105D4B ABC, transporter B4918_16780 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane B4918_16790 ENOG4105DKT Transcriptional regulator B4918_16795 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) B4918_16805 ENOG41061GT Aldolase B4918_16825 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) B4918_16860 ENOG4105II7 pyrroline-5-carboxylate reductase B4918_16890 ENOG4105E0Y RtcB Protein B4918_16895 ENOG4105ECK Fatty Acid Desaturase B4918_16905 ENOG4107RBI VanW family B4918_16910 ENOG4105G6Z alkaline phosphatase B4918_16920 ENOG4105VMP Transcriptional regulator B4918_16940 ENOG41068WN B4918_16970 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B4918_16995 ENOG4105C8Y Acetylornithine aminotransferase B4918_17000 ENOG4105CH6 catalase B4918_17030 ENOG41090AA B4918_17045 ENOG4108IBT Inherit from COG: transposase B4918_17065 ENOG4108TVJ Nitroreductase B4918_17070 ENOG4105FS7 Transcriptional regulator B4918_17090 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B4918_17095 ENOG4105WEC Molybdate metabolism regulator B4918_17100 ENOG4105CMR udp-glucose 4-epimerase B4918_17105 ENOG4105C19 ABC transporter B4918_17130 ENOG4108XET gCN5-related N-acetyltransferase B4918_17140 ENOG4105E09 nadh pyrophosphatase B4918_17145 ENOG4108PCN EamA-like transporter family B4918_17190 ENOG410635A Membrane B4918_17200 ENOG4108IQI permease B4918_17265 ENOG4105BZU Histidine kinase B4918_17295 ENOG4107RF6 penicillin-binding protein B4918_17300 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) B4918_17330 ENOG4105P4J Allophanate hydrolase, subunit 1 B4918_17335 ENOG4107258 Transcriptional regulator B4918_17345 ENOG4106N3A copper homeostasis protein cutc B4918_17350 ENOG4108ZHR arsR family transcriptional regulator B4918_17360 ENOG4105FDT acyl-CoA dehydrogenase B4918_17375 ENOG4105DWD nucleoside recognition domain protein B4918_17415 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) B4918_17445 ENOG4105E2A Dehydrogenase B4918_17455 ENOG4108IJ0 Aspartate ammonia-lyase B4918_17460 ENOG4105HDK L-asparaginase B4918_17465 ENOG4108IMY Transcriptional regulator B4918_17485 ENOG4108B31 Spore germination protein B4918_17495 ENOG4105BZU Histidine kinase B4918_17520 ENOG41075H3 AraC family transcriptional regulator B4918_17535 ENOG4105YWU small acid-soluble spore protein B4918_17540 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B4918_17545 ENOG4105CUB amino acid B4918_17550 ENOG4105II7 pyrroline-5-carboxylate reductase B4918_17555 ENOG4108NHD germination protein B4918_17560 ENOG4108Q8B Spore germination protein B4918_17600 ENOG4106A3M Cytochrome p-450 B4918_17615 ENOG4105CGH 5'-nucleotidase B4918_17625 ENOG4105CHJ isochorismatase hydrolase B4918_17680 ENOG4105F6J Alpha beta hydrolase fold B4918_17695 ENOG4108606 TspO/MBR family B4918_17700 ENOG4105CVP deoxyribo-dipyrimidine photolyase B4918_17715 ENOG4108TWJ NADH dehydrogenase subunit 5 B4918_17720 ENOG4105GPN Uncharacterized conserved protein (DUF2294) B4918_17735 ENOG4105E1K spore germination protein B4918_17740 ENOG4107VMI polysaccharide deacetylase B4918_17750 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B4918_17755 ENOG4105DSE periplasmic solute binding protein B4918_17760 ENOG4105CC5 ABC transporter B4918_17765 ENOG4105DIK (ABC) transporter B4918_17785 ENOG4105D6J arsenicaL-resistance protein B4918_17790 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_17795 ENOG41085FC arsR family transcriptional regulator B4918_17810 ENOG4105EGI Transcriptional regulator B4918_17840 ENOG41085W3 Transposase B4918_17860 ENOG4105VZ8 Transcriptional regulator B4918_17870 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) B4918_17885 ENOG4107P5I polyketide synthase B4918_17890 ENOG4108IG5 Transcriptional regulator B4918_17895 ENOG4105CHR reductase B4918_17900 ENOG4108YXU transcriptional regulator AsnC family B4918_17950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_17955 ENOG41062D9 Histidine kinase B4918_17995 ENOG4105DNP FAD linked oxidase domain protein B4918_18010 ENOG4105C19 ABC transporter B4918_18045 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B4918_18050 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_18070 ENOG4105K6H D-cysteine desulfhydrase B4918_18090 ENOG4105JQZ Methyltransferase B4918_18110 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) B4918_18120 ENOG4105BZU Histidine kinase B4918_18135 ENOG4108U05 Transcriptional regulator B4918_18150 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B4918_18165 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B4918_18185 ENOG4108JQ1 Dehydrogenase B4918_18190 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B4918_18205 ENOG41082W1 Cupin 2, conserved barrel domain protein B4918_18215 ENOG410874W AraC family transcriptional regulator B4918_18240 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_18250 ENOG4108IG5 Transcriptional regulator B4918_18450 ENOG4108VXD carboxy-peptidase B4918_18455 ENOG4105PNM synthesis protein B4918_18465 ENOG4108ISG Major Facilitator B4918_18480 ENOG4107MII Sugar-specific transcriptional regulator TrmB B4918_18485 ENOG4105CZM Major Facilitator B4918_18500 ENOG4105CRW Short chain fatty acid transporter B4918_18510 ENOG4105DYS nad(p)h dehydrogenase (quinone) B4918_18570 ENOG4108K8S endonuclease I B4918_18580 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) B4918_18585 ENOG4108Z66 YbaK ebsC protein B4918_18605 ENOG4105KVH Transcriptional regulator B4918_18610 ENOG4108RCM Nitroreductase B4918_18645 ENOG4108PSK reductase B4918_18725 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_18730 ENOG4105DKQ ROK family B4918_18735 ENOG4106UW1 Major Facilitator superfamily B4918_18740 ENOG4108UW5 maltose o-acetyltransferase B4918_18745 ENOG4105C31 Tryptophanyl-tRNA synthetase B4918_18750 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) B4918_18800 ENOG4105EV4 Multidrug resistance protein mdtH B4918_18830 ENOG4105C37 (CBS) domain B4918_18855 ENOG4105DDN Pentapeptide repeat-containing protein B4918_18860 ENOG4105XDF Protein of unknown function (DUF1272) B4918_18865 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B4918_18870 ENOG4105CMG Carbohydrate kinase B4918_18875 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) B4918_18885 ENOG4105CV1 Transketolase (EC 2.2.1.1) B4918_18890 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B4918_18915 ENOG4105C44 Serine transporter B4918_18945 ENOG4105KVH Transcriptional regulator B4918_18950 ENOG4108TZY GntR Family Transcriptional Regulator B4918_18955 ENOG4105D9R oxidoreductase B4918_19010 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B4918_19015 ENOG4105KVH Transcriptional regulator B4918_19020 ENOG4107SCK Monooxygenase B4918_19035 ENOG4108ZJ4 polysaccharide deacetylase B4918_19090 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) B4918_19160 ENOG4105CIS alcohol dehydrogenase B4918_19200 ENOG4108TN2 lmbE family B4918_19210 ENOG4107R3E Citrate transporter B4918_19225 ENOG4108MES Periplasmic binding protein B4918_19230 ENOG4105EHG Permease protein B4918_19235 ENOG4105DQ5 transport system permease protein B4918_19240 ENOG4105NX3 Membrane B4918_19260 ENOG4107CUJ Protein of unknown function (DUF2690) B4918_19270 ENOG4107V2S Transcriptional regulator B4918_19290 ENOG4105C98 muts2 protein B4918_19300 ENOG4105E5K Alpha-amylase B4918_19305 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_19310 ENOG4105DPN Oligoendopeptidase f B4918_19315 ENOG4105DWY Agmatine deiminase B4918_19345 ENOG4108A04 Beta-lactamase B4918_19355 ENOG4105E5T Major Facilitator Superfamily B4918_19370 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B4918_19380 ENOG41082BM Transcriptional regulator, arsr family B4918_19385 ENOG4105CIS alcohol dehydrogenase B4918_19410 ENOG4105C09 Bile acid B4918_19415 ENOG4105CQB FAD linked oxidase domain protein B4918_19435 ENOG4105CEP NADH dehydrogenase B4918_19460 ENOG4105D2T synthase B4918_19475 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) B4918_19480 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_19485 ENOG4105C1B dTDP-glucose 4-6-dehydratase B4918_19490 ENOG4105C5E polysaccharide biosynthesis protein B4918_19515 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B4918_19520 ENOG4108M1A Chitin-binding protein B4918_19530 ENOG4105E1K spore germination protein B4918_19550 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase B4918_19565 ENOG4105FAW cDP-glucose 4,6-dehydratase B4918_19620 ENOG4105BZU Histidine kinase B4918_19625 ENOG4105C5H ABC transporter B4918_19630 ENOG41067SE Tetr family transcriptional regulator B4918_19635 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity B4918_19645 ENOG4108VXD carboxy-peptidase B4918_19650 ENOG4107DUR UPF0457 protein B4918_19670 ENOG4105BZU Histidine kinase B4918_19680 ENOG4105KT7 mgtC SapB transporter B4918_19690 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_19695 ENOG41073R8 VanW family B4918_19705 ENOG4108R1P B4918_19725 ENOG4105VEQ Cold shock protein B4918_19745 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) B4918_19765 ENOG410904N short-chain dehydrogenase reductase B4918_19775 ENOG4106IQC argininosuccinate lyase B4918_19790 ENOG4108IA2 Sodium pantothenate symporter B4918_19800 ENOG4105C26 Dehydrogenase B4918_19805 ENOG4105CHR reductase B4918_19815 ENOG4105EWU Squalene--hopene cyclase B4918_19825 ENOG4105FR1 rard protein B4918_19830 ENOG410696E Membrane B4918_19845 ENOG4105D1F ATP-binding protein B4918_19855 ENOG4108ZAF Molybdopterin B4918_19860 ENOG4105CVM Molybdenum cofactor synthesis domain protein B4918_19865 ENOG4105D06 uba thif-type nad fad binding protein B4918_19870 ENOG4105TMB Formate nitrite transporter B4918_19885 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B4918_19890 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B4918_19900 ENOG4108JB9 formate dehydrogenase B4918_19910 ENOG4105E1K spore germination protein B4918_19980 ENOG4107QJT sodium dicarboxylate symporter B4918_19985 ENOG4108KGH TRANSCRIPTIONal B4918_19995 ENOG4105EMN RNA polymerase sigma factor B4918_20005 ENOG4105CIG ABC transporter B4918_20025 ENOG4105D9R oxidoreductase B4918_20035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B4918_20045 ENOG4105K4P CoA-binding domain protein B4918_20050 ENOG4105C0H protease B4918_20055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_20065 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase B4918_20070 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B4918_20075 ENOG4105W8X HesB YadR YfhF-family protein B4918_20100 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B4918_20105 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B4918_20120 ENOG4108I0Z Aconitate hydratase B4918_20150 ENOG4105E5W Transporter B4918_20160 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B4918_20180 ENOG4107F3J Amp-dependent synthetase and ligase B4918_20185 ENOG4107ZYJ bioY protein B4918_20190 ENOG4105CEY Amp-dependent synthetase and ligase B4918_20195 ENOG4108IMY Transcriptional regulator B4918_20235 ENOG4107AYK membrAne B4918_20250 ENOG4105BZU Histidine kinase B4918_20255 ENOG4105FBA Phospholipase Carboxylesterase B4918_20260 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B4918_20265 ENOG4105CK7 Sodium proline symporter B4918_20275 ENOG4105CBC glutamate synthase B4918_20280 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B4918_20285 ENOG4108VJ1 Transcriptional regulator (CarD family B4918_20290 ENOG4108903 Formimidoylglutamase B4918_20350 ENOG4107QIV Cytochrome c biogenesis protein B4918_20365 ENOG4105CH2 amidohydrolase B4918_20375 ENOG4105CJ1 ABC, transporter B4918_20395 ENOG4107RSM transcriptional regulator B4918_20400 ENOG4105VAW lrga family B4918_20450 ENOG4105BZ1 (ABC) transporter B4918_20455 ENOG4105BZ1 (ABC) transporter B4918_20490 ENOG4108HW3 (ABC) transporter B4918_20495 ENOG4105CGH 5'-nucleotidase B4918_20505 ENOG4108SVB resolvase B4918_20525 ENOG4105K7K Transcriptional regulator B4918_20530 ENOG4105C5F glutamine synthetase B4918_20535 ENOG4105KV4 Transcriptional regulator B4918_20540 ENOG4105CXI aluminum resistance protein B4918_20545 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B4918_20550 ENOG4105EN6 Membrane B4918_20555 ENOG4106F1P AAA ATPase, central domain protein B4918_20585 ENOG41069ER domain protein B4918_20595 ENOG4105DM4 PTS System B4918_20600 ENOG4105DE4 1-phosphofructokinase B4918_20605 ENOG4105E98 transcriptional regulator DeoR family B4918_20610 ENOG4107QW4 alcohol dehydrogenase B4918_20615 ENOG4108SJC Membrane B4918_20630 ENOG4105C85 amino acid B4918_20660 ENOG4105TMB Formate nitrite transporter B4918_20665 ENOG4105K70 DNA-binding protein B4918_20675 ENOG4105C59 p-type ATPase B4918_20680 ENOG410681U heavy metal transport detoxification protein B4918_20685 ENOG4105VPX protein, conserved in bacteria B4918_20705 ENOG4105NIV Esterase B4918_20710 ENOG4105E0A ABC, transporter B4918_20735 ENOG4105CGK Exodeoxyribonuclease III B4918_20745 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B4918_20750 ENOG4105D03 DNA-3-methyladenine glycosylase II B4918_20780 ENOG4105BZU Histidine kinase B4918_20820 ENOG41067MG lrgb family B4918_20845 ENOG4105C8Q Methyl-accepting chemotaxis B4918_20850 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C B4918_20860 ENOG4105F0V Cell wall hydrolase B4918_20875 ENOG4105E0M Sulfatase B4918_20880 ENOG410890F Dynamin family B4918_20915 ENOG4105DQU oxidoreductase, subunit beta B4918_20920 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein B4918_20925 ENOG4108IGT Dipeptidase B4918_20930 ENOG4105MCT stage V sporulation protein S B4918_20935 ENOG4105D48 metallophosphoesterase B4918_20960 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B4918_20975 ENOG4105XZV Protein of unknown function (DUF3243) B4918_20980 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B4918_21000 ENOG4105UIB (ABC) transporter B4918_21005 ENOG4108JQ9 ABC transporter B4918_21010 ENOG4105DIH basic membrane B4918_21015 ENOG4105FDP GntR family transcriptional regulator B4918_21025 ENOG4105CNU cell division protein FtsK B4918_21035 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B4918_21045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B4918_21055 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B4918_21060 ENOG4108S0H Dipicolinic acid synthetase, b subunit B4918_21065 ENOG4105E35 Dipicolinate synthase subunit A B4918_21075 ENOG4105C1V Peptidase, M16 B4918_21095 ENOG4105DTN riboflavin biosynthesis protein ribF B4918_21110 ENOG4105W7A Protein of unknown function (DUF503) B4918_21120 ENOG4105VHM ribosomal protein B4918_21125 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B4918_21130 ENOG4105CHV Transcription elongation factor NusA B4918_21140 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B4918_21150 ENOG4105DZP Membrane-associated zinc metalloprotease B4918_21155 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) B4918_21160 ENOG4105KNE Phosphatidate cytidylyltransferase B4918_21165 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B4918_21175 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) B4918_21205 ENOG4108HE4 integrase family B4918_21215 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B4918_21220 ENOG4105C79 DNA protecting protein DprA B4918_21225 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B4918_21240 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B4918_21265 ENOG4105VB6 UPF0109 protein B4918_21285 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B4918_21290 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B4918_21305 ENOG4105CHR reductase B4918_21310 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B4918_21325 ENOG4105CB5 ATP-dependent DNA helicase recG B4918_21330 ENOG4105DP4 dak2 domain fusion protein ylov B4918_21335 ENOG4108ZAA Alkaline-shock protein B4918_21350 ENOG4105FJ0 thiamine B4918_21355 ENOG4105DJV ribulose-phosphate 3-epimerase B4918_21360 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B4918_21365 ENOG4105D9P serine threonine protein kinase B4918_21370 ENOG4108ZF3 Phosphatase B4918_21380 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B4918_21395 ENOG4105C25 Primosomal protein n' B4918_21400 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B4918_21420 ENOG4105DSJ YicC domain protein B4918_21430 ENOG4105F23 Fibronectin-binding protein B4918_21520 ENOG4105C34 Pseudouridine synthase B4918_21535 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) B4918_21545 ENOG4105DBK s4 domain protein B4918_21550 ENOG41067XK integral membrane protein B4918_21560 ENOG4105DFA alanine racemase domain protein B4918_21565 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B4918_21570 ENOG4105WR5 sporulation protein, YlmC YmxH family B4918_21580 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_21590 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B4918_21595 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B4918_21605 ENOG4105D4A Cell wall formation (By similarity) B4918_21610 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B4918_21615 ENOG4105CNI cell division protein FtsW B4918_21630 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B4918_21635 ENOG4105CJN penicillin-binding protein B4918_21640 ENOG4105CJN penicillin-binding protein B4918_21680 ENOG4105KNH Nucleic acid-binding protein B4918_21690 ENOG41063PX domain protein B4918_21695 ENOG4105D78 K07001 NTE family protein B4918_21700 ENOG4105H20 Sporulation integral membrane protein YlbJ B4918_21710 ENOG4106H78 methyltransferase B4918_21730 ENOG4107TB6 phosphoglycerate mutase B4918_21745 ENOG4106UY4 Inherit from COG: Scp-like extracellular B4918_21795 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B4918_21805 ENOG4105CNI cell division protein FtsW B4918_21820 ENOG4108IAB Phoh family B4918_21840 ENOG4105QA2 B4918_21845 ENOG4105CI3 gtp-binding protein typa B4918_21855 ENOG4105ECY inositol monophosphatase B4918_21875 ENOG4105CXN decarboxylase B4918_21925 ENOG4105CPP Dehydrogenase, E1 component B4918_21940 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B4918_21945 ENOG4108X4Q Hydrolase B4918_21960 ENOG4105CN5 Metallo-Beta-Lactamase B4918_21965 ENOG4107ZYR domain protein B4918_22000 ENOG4108XRC Protein of unknown function (DUF458) B4918_22010 ENOG4107IN1 Protein of unknown function (DUF1797) B4918_22025 ENOG4105EPM Diguanylate phosphodiesterase B4918_22030 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B4918_22055 ENOG4105UIN B4918_22105 ENOG4105EKQ RNA-directed DNA polymerase B4918_22120 ENOG4108HGU Histidine kinase B4918_22130 ENOG4105CHM Aminotransferase B4918_22135 ENOG4105FKQ transcriptional regulator B4918_22140 ENOG4105EG2 ABC transporter, permease B4918_22150 ENOG4107FKK extracellular solute-binding protein family 1 B4918_22160 ENOG4105CG3 alpha amylase, catalytic region B4918_22205 ENOG4105CHU acetyl-coa acetyltransferase B4918_22240 ENOG4105K7K Transcriptional regulator B4918_22245 ENOG4105DTD Dehydrogenase B4918_22265 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B4918_22290 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) B4918_22305 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B4918_22315 ENOG4105BZU Histidine kinase B4918_22335 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B4918_22350 ENOG4105CID antiterminator B4918_22360 ENOG4105FDP GntR family transcriptional regulator B4918_22370 ENOG4105CE4 GlcNAc 6-P deacetylase B4918_22410 ENOG4107ZE5 PPIases accelerate the folding of proteins B4918_22415 ENOG4105PTM secreted protein B4918_22420 ENOG4105J7I hydrolase B4918_22430 ENOG4105G6R Stage v sporulation protein ae B4918_22440 ENOG4105CZ3 stage V sporulation protein ad B4918_22445 ENOG41090VF Stage v sporulation protein ac B4918_22465 ENOG4105C8J )-transporter B4918_22470 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_22480 ENOG41082AN stage II sporulation protein B4918_22485 ENOG4105DZ1 carboxypeptidase B4918_22495 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B4918_22500 ENOG4105DVE abc transporter atp-binding protein B4918_22535 ENOG4105D7N magnesium and cobalt transport protein CorA B4918_22560 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_22570 ENOG4105I3K Ferric uptake regulator, Fur family B4918_22575 ENOG4105MZ9 stage II sporulation protein m B4918_22595 ENOG4105CPC Aldo Keto reductase B4918_22605 ENOG4105RHY Pfam:UPF0157 B4918_22625 ENOG4107SKW Inherit from COG: Alpha beta hydrolase B4918_22635 ENOG4105ETE Transcriptional regulator (LacI family B4918_22640 ENOG4108YM7 Gcn5-related n-acetyltransferase B4918_22660 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B4918_22665 ENOG4108R6K riboflavin synthase, subunit alpha B4918_22690 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B4918_22695 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) B4918_22710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B4918_22725 ENOG4105DFD Na H antiporter B4918_22730 ENOG4105CGH 5'-nucleotidase B4918_22755 ENOG4105DBV ornithine carbamoyltransferase B4918_22770 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) B4918_22785 ENOG4108IXY short-chain dehydrogenase reductase B4918_22790 ENOG41069FQ Metallo-beta-lactamase superfamily B4918_22795 ENOG4105II7 pyrroline-5-carboxylate reductase B4918_22800 ENOG4105EJQ L-serine dehydratase B4918_22830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic B4918_22845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B4918_22850 ENOG4105D9U N-acetyltransferase B4918_22865 ENOG4108VZI ErfK ybiS ycfS ynhG family protein B4918_22870 ENOG4108QEG Membrane B4918_22875 ENOG4105CDA abc transporter atp-binding protein B4918_22880 ENOG4105E5Q amino acid AbC transporter B4918_22885 ENOG4108HW3 (ABC) transporter B4918_22895 ENOG4105G7B Protein of unknown function (DUF2992) B4918_22905 ENOG4108QY0 Membrane B4918_22920 ENOG4105C7S Dehydrogenase B4918_22925 ENOG4105CPP Dehydrogenase, E1 component B4918_22945 ENOG4107RDP Dehydrogenase B4918_22960 ENOG4108JUB Transcriptional regulator B4918_22970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B4918_22985 ENOG4107QQR Sporulation B4918_22995 ENOG4105S1Z Stage IV sporulation protein B B4918_23000 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B4918_23005 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) B4918_23010 ENOG4105DX0 Hemolysin A B4918_23020 ENOG4105CTB Polyprenyl synthetase B4918_23045 ENOG4108ZSR alkaline shock protein B4918_23050 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B4918_23075 ENOG410644B Stage III sporulation protein af B4918_23085 ENOG4105KQ4 Stage iii sporulation protein ad B4918_23090 ENOG4108CQH stage III sporulation protein AC B4918_23095 ENOG4105KR5 Stage iii sporulation protein B4918_23100 ENOG4105CD2 stage iii sporulation protein aa B4918_23125 ENOG4105DC7 peptidase M24 B4918_23130 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B4918_23140 ENOG4105CBJ Metal-dependent enzyme B4918_23150 ENOG4107YBY Hydrolase B4918_23180 ENOG41082GG biotin lipoate A B protein ligase B4918_23185 ENOG4105WZW rhodanese family B4918_23210 ENOG41080TC multidrug resistance protein B4918_23260 ENOG4105C0D helicase B4918_23350 ENOG4107R6U sodium dicarboxylate symporter B4918_23385 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B4918_23390 ENOG4105C3R Methionine synthase B4918_23400 ENOG4105C28 cystathionine B4918_23405 ENOG4105C28 cystathionine B4918_23425 ENOG4105C5X domain protein B4918_23435 ENOG4105DKQ ROK family B4918_23445 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B4918_23460 ENOG4108UTW Plays a role in the regulation of phosphate uptake B4918_23465 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B4918_23470 ENOG4105C8U phosphate abc transporter B4918_23475 ENOG4105C8U phosphate abc transporter B4918_23485 ENOG4107RF6 penicillin-binding protein B4918_23495 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B4918_23520 ENOG4105N80 Ferric uptake regulator, Fur family B4918_23530 ENOG4105FDK ABC transporter B4918_23535 ENOG4108JYZ YitT family B4918_23540 ENOG41069ZM Protein of unknown function (DUF2624) B4918_23565 ENOG4105EGD dinuclear metal center protein, YbgI family B4918_23580 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_23585 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B4918_23595 ENOG4107XJU UPF0178 protein B4918_23620 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B4918_23625 ENOG4105KG3 cytidine deaminase B4918_23630 ENOG4107YR5 Diacylglycerol kinase B4918_23640 ENOG4105CTJ Metal Dependent Phosphohydrolase B4918_23645 ENOG4105C9A Phoh family B4918_23655 ENOG41068P3 sporulation protein YqfC B4918_23665 ENOG4105KTH gatB Yqey B4918_23675 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B4918_23680 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B4918_23710 ENOG4105CSA Coproporphyrinogen iii oxidase B4918_23715 ENOG4105KVH Transcriptional regulator B4918_23740 ENOG4105TQK DNA polymerase iii, delta' subunit B4918_23750 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B4918_23755 ENOG4108UK2 deaminase B4918_23760 ENOG4105KQC Competence protein B4918_23775 ENOG4105DXX methyltransferase B4918_23785 ENOG4108WF2 Metal Dependent Phosphohydrolase B4918_23795 ENOG410812S Rna-binding protein B4918_23805 ENOG4105CQW ribosome biogenesis GTPase YqeH B4918_23810 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B4918_23825 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_23845 ENOG4108TVJ Nitroreductase B4918_23860 ENOG4105G6Z alkaline phosphatase B4918_23865 ENOG4105KEG ribosomal-protein-alanine acetyltransferase B4918_23870 ENOG4108MUZ hydrolase B4918_23905 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B4918_23910 ENOG4105MIR Phenylalanine 4-monooxygenase B4918_23920 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B4918_23960 ENOG4105S6R Iron-hydroxamate transporter permease subunit B4918_23965 ENOG4108V5C ABC transporter B4918_23980 ENOG4108EKI Dehydrogenase B4918_23985 ENOG4105C28 cystathionine B4918_24015 ENOG4107XRG penicillin-binding protein B4918_24025 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) B4918_24035 ENOG4105CFP Peptidase U32 B4918_24040 ENOG4105XYU peptidase (U32 family) B4918_24045 ENOG4108VQJ O-methyltransferase B4918_24050 ENOG4105HHA aminodeoxychorismate lyase B4918_24070 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B4918_24080 ENOG4105C02 permease B4918_24095 ENOG41060CR B4918_24100 ENOG4105C7H Helicase, RecD TraA family B4918_24110 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B4918_24115 ENOG4105C3J Cysteine desulfurase B4918_24125 ENOG4105D1H recombination factor protein RarA B4918_24130 ENOG4108VCI transcription factor, rsfa family B4918_24140 ENOG4105CUZ uba thif-type nad fad binding protein B4918_24155 ENOG4105CUT histidyl-tRNA synthetase B4918_24175 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B4918_24185 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B4918_24190 ENOG41076HS cation diffusion facilitator family transporter B4918_24195 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B4918_24205 ENOG4105CKP Polysaccharide Biosynthesis Protein B4918_24210 ENOG4108QG2 Membrane B4918_24220 ENOG4105VIE preprotein translocase, subunit YajC B4918_24235 ENOG41061AI Protein of unknown function (DUF2905) B4918_24250 ENOG4108HUF Transporter B4918_24280 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B4918_24285 ENOG4108IYU L-aspartate oxidase B4918_24300 ENOG4108RPX mosc domain containing protein B4918_24310 ENOG4105CQC Prephenate dehydratase B4918_24330 ENOG4105EWM Histidine kinase B4918_24355 ENOG4105X36 (ribosomal) protein B4918_24365 ENOG4105C03 ribonuclease B4918_24380 ENOG4107QMS site-determining protein B4918_24395 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B4918_24400 ENOG4105DFF Rod shape-determining protein mreb B4918_24430 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_24630 ENOG4108C33 Resolvase B4918_24650 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B4918_24655 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B4918_24665 ENOG41068KH stage VI sporulation protein D B4918_24675 ENOG4105D52 delta-aminolevulinic acid dehydratase B4918_24700 ENOG4105K56 Transcriptional regulator B4918_24720 ENOG4108IUQ atp-dependent protease B4918_24750 ENOG4108QCI YvbH-like oligomerisation region B4918_24805 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_24825 ENOG4105M59 Phosphodiesterase, mj0936 family B4918_24830 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) B4918_24840 ENOG4108XJQ germination protein B4918_24850 ENOG4108PCX Major Facilitator B4918_24860 ENOG4105KBX Transcriptional regulator, TetR family B4918_24870 ENOG4105PFC Transcriptional regulator B4918_24880 ENOG4105DZC cytosine deaminase B4918_24885 ENOG41067S9 phage shock protein C, PspC B4918_24890 ENOG4108JCI Transcriptional regulator B4918_24905 ENOG4105EKQ RNA-directed DNA polymerase B4918_24915 ENOG4108Z40 Transcriptional regulator B4918_24920 ENOG4105RHA ABC transporter, permease B4918_24925 ENOG4108IUX (ABC) transporter B4918_24930 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family B4918_24935 ENOG4105ER2 Ompa motb domain protein B4918_24940 ENOG4105E14 MotA TolQ exbB proton channel B4918_24945 ENOG4108VXD carboxy-peptidase B4918_24955 ENOG4105E33 succinate dehydrogenase B4918_24965 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B4918_24980 ENOG4105K63 Thioredoxin B4918_24985 ENOG4105C10 Electron transfer flavoprotein B4918_24990 ENOG4105BZJ Electron transfer flavoprotein B4918_24995 ENOG41060WC Enoyl-CoA hydratase B4918_25000 ENOG4107Z3H Transcriptional regulator, TetR family B4918_25005 ENOG4105CEY Amp-dependent synthetase and ligase B4918_25015 ENOG4105J76 Periplasmic binding protein B4918_25020 ENOG4105S6R Iron-hydroxamate transporter permease subunit B4918_25060 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_25075 ENOG4105DR4 Methyltransferase B4918_25085 ENOG4105KFN sortase, SrtB family B4918_25090 ENOG4105E0A ABC, transporter B4918_25105 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) B4918_25115 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) B4918_25125 ENOG4105FE9 pseudouridine synthase B4918_25140 ENOG4105DCG PHP domain protein B4918_25155 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B4918_25170 ENOG4105C5S asparaginyl-tRNA synthetase B4918_25175 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B4918_25185 ENOG4108RWN rrna methyltransferase B4918_25210 ENOG4105C0R drug resistance transporter emrb qaca subfamily B4918_25215 ENOG4105CW7 secretion protein, HlyD family B4918_25220 ENOG4108JGH Tetr family transcriptional regulator B4918_25225 ENOG4105CN9 Peptidase m42 family protein B4918_25245 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B4918_25250 ENOG4105C22 threonyL-tRNA synthetase B4918_25255 ENOG4108TDW sporulation protein YtxC B4918_25280 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B4918_25290 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B4918_25295 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B4918_25305 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B4918_25310 ENOG4105C2M dna polymerase I B4918_25315 ENOG4105BZU Histidine kinase B4918_25320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_25350 ENOG4108HMX isocitrate dehydrogenase (NADP) B4918_25355 ENOG4105BZN citrate synthase B4918_25370 ENOG4108REF Sporulation integral membrane protein ytvi B4918_25375 ENOG4105FS0 cytoplasmic membrane protein B4918_25400 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B4918_25405 ENOG4105C6K Malic enzyme B4918_25410 ENOG4105C0B DNA polymerase III (alpha subunit) B4918_25415 ENOG4105VV2 B4918_25425 ENOG4105SFS phosphoesterase RecJ domain protein B4918_25455 ENOG4105DC7 peptidase M24 B4918_25485 ENOG4105Z7P Acetyltransferase (GNAT) family B4918_25490 ENOG41082W1 Cupin 2, conserved barrel domain protein B4918_25510 ENOG4107YZX Universal stress protein B4918_25565 ENOG4108JYZ YitT family B4918_25585 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B4918_25595 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B4918_25600 ENOG4105KBJ sporulation protein ytfj B4918_25615 ENOG4105EFZ amidohydrolase B4918_25625 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B4918_25650 ENOG4107RSM transcriptional regulator B4918_25660 ENOG4105U5Y Transcriptional regulator B4918_25670 ENOG4105C28 cystathionine B4918_25790 ENOG4108UW5 maltose o-acetyltransferase B4918_25800 ENOG4105F1V Acetoin utilization protein B4918_25805 ENOG4105W87 Cbs domain B4918_25810 ENOG4105DGU Histone deacetylase B4918_25825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B4918_25830 ENOG4105BZU Histidine kinase B4918_25835 ENOG4107SNB ankyrin repeat protein YahD B4918_25840 ENOG4105EP9 oxidoreductase B4918_25870 ENOG4105ETE Transcriptional regulator (LacI family B4918_25890 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B4918_25910 ENOG4105C88 aminopeptidase B4918_25930 ENOG4108IPJ Membrane B4918_25965 ENOG4108VDD TRNA binding domain protein B4918_25995 ENOG4105C8F Beta-lactamase domain protein B4918_26010 ENOG4108V15 phosphotransferase enzyme family B4918_26015 ENOG4108IUM Glycogen debranching enzyme B4918_26030 ENOG4107QSE Dipeptidase B4918_26035 ENOG4105YW5 deoR family transcriptional regulator B4918_26050 ENOG4105CBX hi0933 family B4918_26095 ENOG4108VJ1 Transcriptional regulator (CarD family B4918_26100 ENOG4107EXU Short-chain dehydrogenase reductase Sdr B4918_26105 ENOG4105CSC Glucose uptake protein B4918_26120 ENOG4108ZAF Molybdopterin B4918_26125 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B4918_26130 ENOG4105CVM Molybdenum cofactor synthesis domain protein B4918_26140 ENOG4105D06 uba thif-type nad fad binding protein B4918_26145 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B4918_26170 ENOG41085GJ domain protein B4918_26180 ENOG4105DWV Homoserine O-trans-acetylase B4918_26220 ENOG410605W Major Facilitator B4918_26225 ENOG4107S91 Sodium hydrogen exchanger B4918_26230 ENOG4105NCW Trka-c domain protein B4918_26265 ENOG4105N5T Radical SAM Protein B4918_26295 ENOG4105E8V Alpha Beta Hydrolase Fold protein B4918_26300 ENOG4108Z0R Transferase B4918_26305 ENOG4105YVM Phosphoesterase, PA-phosphatase related B4918_26310 ENOG4105BZF Glycosyl transferase (Group 1 B4918_26320 ENOG4105EPU Molybdenum cofactor synthesis domain protein B4918_26410 ENOG4105BZU Histidine kinase B4918_26415 ENOG4105BZU Histidine kinase B4918_26420 ENOG4105CH6 catalase B4918_26425 ENOG4107S9D Alpha beta hydrolase B4918_26430 ENOG4107T7U Sulfatase B4918_26455 ENOG4105D2X ABC transporter substrate-binding protein B4918_26465 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B4918_26525 ENOG41080TC multidrug resistance protein B4918_26530 ENOG410839T multidrug resistance protein B4918_26550 ENOG4108V2W Carbonate dehydratase B4918_26555 ENOG4105C4M (Ubiquinol oxidase) subunit I B4918_26560 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B4918_26605 ENOG41087YS Phage shock protein A B4918_26630 ENOG4105N67 Proton-coupled thiamine transporter YuaJ B4918_26635 ENOG4105BZU Histidine kinase B4918_26640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_26665 ENOG4108UGV hypoxanthine phosphoribosyltransferase B4918_26670 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B4918_26715 ENOG4107ZTW SNARE associated Golgi B4918_26730 ENOG4105C19 ABC transporter B4918_26745 ENOG4105CJ1 ABC, transporter B4918_26755 ENOG41082BM Transcriptional regulator, arsr family B4918_26800 ENOG4105C6Z Gluconate B4918_26805 ENOG4105FDP GntR family transcriptional regulator B4918_26825 ENOG41069H0 dihydroorotase EC 3.5.2.3 B4918_26850 ENOG4105DTQ mandelate racemase muconate lactonizing B4918_26860 ENOG4108IPT Naphthoate synthase B4918_26865 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B4918_26875 ENOG4105E4F Isochorismate synthase B4918_26880 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B4918_26890 ENOG4105VEQ Cold shock protein B4918_26935 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B4918_26960 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B4918_26965 ENOG4108Q5F Tetr family transcriptional regulator B4918_27105 ENOG4105KT7 mgtC SapB transporter B4918_27110 ENOG4107PBV potassium channel B4918_27130 ENOG4105WG9 Conserved Protein B4918_27140 ENOG4105CHM Aminotransferase B4918_27145 ENOG4108ZB6 transcriptional regulator AsnC family B4918_27150 ENOG4105C5I Dehydrogenase B4918_27155 ENOG4108MUZ hydrolase B4918_27165 ENOG4105C87 Aminotransferase class I and II B4918_27180 ENOG4105Y38 Kinase-associated protein B B4918_27190 ENOG4107R3E Citrate transporter B4918_27210 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) B4918_27215 ENOG4105KA0 thioesterase Superfamily protein B4918_27230 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B4918_27250 ENOG41069ER domain protein B4918_27265 ENOG4105CEP NADH dehydrogenase B4918_27290 ENOG4105EWC Purine nucleoside phosphorylase B4918_27315 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B4918_27340 ENOG4108JJA ABC, transporter B4918_27345 ENOG4105C4B ABC transporter, permease B4918_27350 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA B4918_27405 ENOG41083MR nifu domain-containing protein B4918_27420 ENOG4108W5N phosphatidylglycerophosphatase a B4918_27440 ENOG4105DAX Pfam:DUF2983 B4918_27450 ENOG4105DYS nad(p)h dehydrogenase (quinone) B4918_27455 ENOG4105D4U had-superfamily hydrolase, subfamily iia B4918_27470 ENOG4105CBT Fructose-1,6-bisphosphatase B4918_27490 ENOG4105MMD transcriptional regulator B4918_27495 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B4918_27500 ENOG4107TXC Transcriptional regulator B4918_27505 ENOG41090T1 Membrane B4918_27530 ENOG4105FAA peptidase M23 B4918_27535 ENOG4108YTE sporulation protein YunB B4918_27540 ENOG4105KZD Domain of unknown function (DUF1805) B4918_27545 ENOG4107R8B 5'-nucleotidase B4918_27580 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B4918_27585 ENOG4105XSJ toxin secretion phage lysis holin B4918_27725 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B4918_27805 ENOG4106050 phage regulatory protein, rha family B4918_27820 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B4918_27825 ENOG4105VTR Integrase B4918_27830 ENOG4105DIW FeS assembly protein SUFB B4918_27835 ENOG4108UNV SUF system FeS assembly protein, NifU family B4918_27840 ENOG4105C9B Cysteine desulfurase B4918_27845 ENOG4105JRK feS assembly protein SufD B4918_27850 ENOG4105C3K feS assembly ATPase SufC B4918_27855 ENOG4105D01 (LipO)protein B4918_27860 ENOG4105D01 (LipO)protein B4918_27865 ENOG4108UMI ABC transporter, permease B4918_27870 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B4918_27895 ENOG41080E8 Transcriptional regulator, Spx MgsR family B4918_27915 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B4918_27940 ENOG4108W8B Beta-lactamase domain protein B4918_27945 ENOG4105C1G acyl-Coa dehydrogenase B4918_27950 ENOG4105CHU acetyl-coa acetyltransferase B4918_27965 ENOG4105DZ1 carboxypeptidase B4918_27985 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B4918_28000 ENOG4108SUT Major Facilitator Superfamily B4918_28005 ENOG4107R7I amino acid B4918_28020 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B4918_28030 ENOG4107AYK membrAne B4918_28070 ENOG4107ZTW SNARE associated Golgi B4918_28080 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein B4918_28085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_28115 ENOG4105C8Q Methyl-accepting chemotaxis B4918_28120 ENOG4105C8Q Methyl-accepting chemotaxis B4918_28125 ENOG4105VG1 fes assembly suf system protein B4918_28130 ENOG4105D4Y metalloprotease B4918_28135 ENOG4105C2I pirin domain protein B4918_28150 ENOG4107T5V SNARE associated Golgi B4918_28155 ENOG4107S91 Sodium hydrogen exchanger B4918_28160 ENOG4105NCW Trka-c domain protein B4918_28175 ENOG4108RMU ferritin dps family protein B4918_28195 ENOG4108URH decarboxylase B4918_28205 ENOG41090A1 ferritin B4918_28215 ENOG4105DHF Membrane B4918_28220 ENOG4105D9N nucleoside B4918_28225 ENOG4105D9N nucleoside B4918_28240 ENOG4108RYK Nad-dependent epimerase dehydratase B4918_28260 ENOG4105CV8 reductase B4918_28265 ENOG4105F27 Major Facilitator B4918_28270 ENOG4105KVH Transcriptional regulator B4918_28290 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B4918_28295 ENOG4105D4A Cell wall formation (By similarity) B4918_28305 ENOG4105C8Q Methyl-accepting chemotaxis B4918_28315 ENOG4105WMR Protein CrcB homolog B4918_28320 ENOG4105WMR Protein CrcB homolog B4918_28340 ENOG4105C5H ABC transporter B4918_28345 ENOG4108MK9 spermidine N(1)-acetyltransferase B4918_28350 ENOG4108VY7 phosphate-starvation-inducible protein PsiE B4918_28360 ENOG4108W2Y isochorismatase B4918_28380 ENOG4108V2W Carbonate dehydratase B4918_28385 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) B4918_28405 ENOG4108IPW abc transporter atp-binding protein B4918_28410 ENOG4105CM4 permease protein B4918_28505 ENOG4105DUX Transporter B4918_28545 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B4918_28555 ENOG4105XZU Preprotein translocase, subunit SecG B4918_28560 ENOG41067MG lrgb family B4918_28610 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_28625 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) B4918_28630 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B4918_28635 ENOG4105XSJ toxin secretion phage lysis holin B4918_28775 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B4918_28850 ENOG4106050 phage regulatory protein, rha family B4918_28875 ENOG4105VTR Integrase B4918_28895 ENOG41090VF Stage v sporulation protein ac B4918_28900 ENOG4105CZ3 stage V sporulation protein ad B4918_28915 ENOG4108QY0 Membrane B4918_28920 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B4918_28930 ENOG4105KRI phosphocarrier protein (HPr B4918_28940 ENOG4105CHW UPF0052 protein B4918_28950 ENOG4108Z4K mutator MutT protein B4918_28960 ENOG4105C3M thioredoxin reductase B4918_28970 ENOG4108S4C acetyltransferase B4918_28990 ENOG41086DT Membrane protein of unknown function B4918_29000 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B4918_29020 ENOG4107TXC Transcriptional regulator B4918_29040 ENOG4105DUM transcriptional regulator, lysR family B4918_29050 ENOG4108WS4 fmn reductase B4918_29055 ENOG4105C5H ABC transporter B4918_29065 ENOG4105BZ1 (ABC) transporter B4918_29075 ENOG4105CN1 protease B4918_29080 ENOG4105CRP Part of the ABC transporter FtsEX involved in B4918_29085 ENOG4105CAK Cell division ATP-binding protein ftsE B4918_29100 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) B4918_29115 ENOG4105MS2 ribosomal subunit Interface protein B4918_29120 ENOG4105VEQ Cold shock protein B4918_29125 ENOG41081UC Inherit from COG: Competence protein B4918_29140 ENOG4105KVH Transcriptional regulator B4918_29155 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B4918_29160 ENOG4108KGH TRANSCRIPTIONal B4918_29165 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B4918_29170 ENOG4105C6Y Udp-glucose 6-dehydrogenase B4918_29175 ENOG4105ESV Glycosyl transferase, family 4 B4918_29185 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B4918_29210 ENOG4105F8D glycoside hydrolase family 4 B4918_29215 ENOG4105VCP PTS System B4918_29220 ENOG4105CK1 PTS System B4918_29230 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B4918_29235 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B4918_29240 ENOG4105VCP PTS System B4918_29255 ENOG4105VZJ PTS System B4918_29280 ENOG4105ECB domain protein B4918_29285 ENOG4107RSM transcriptional regulator B4918_29320 ENOG4105DAA L-lactate B4918_29330 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) B4918_29345 ENOG4105E0M Sulfatase B4918_29380 ENOG4107R8N Glycosyl transferase, family 2 B4918_29390 ENOG4105C94 Transporter B4918_29400 ENOG41069ER domain protein B4918_29425 ENOG4105KBK Zinc finger, swim domain protein B4918_29430 ENOG4105C0D helicase B4918_29440 ENOG41085W3 Transposase B4918_29470 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B4918_29480 ENOG4107RBB ABC transporter, permease B4918_29485 ENOG4105C19 ABC transporter B4918_29495 ENOG4105CXY transporter B4918_29510 ENOG4105BZU Histidine kinase B4918_29515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_29520 ENOG4105CMR udp-glucose 4-epimerase B4918_29525 ENOG4105CMR udp-glucose 4-epimerase B4918_29535 ENOG4108KGH TRANSCRIPTIONal B4918_29545 ENOG4105C6Y Udp-glucose 6-dehydrogenase B4918_29560 ENOG4107T8Q Glycosyl transferase (Group 1 B4918_29565 ENOG4105K64 Glycosyl transferase, family 2 B4918_29570 ENOG4108PQP glycosyl transferase group 1 B4918_29585 ENOG4105D3Q Sugar transferase B4918_29590 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B4918_29600 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B4918_29605 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B4918_29610 ENOG4107YJ4 chain length determinant protein B4918_29615 ENOG4105HTX biosynthesis protein B4918_29620 ENOG4107YJ4 chain length determinant protein B4918_29635 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B4918_29645 ENOG4105FRN stage II sporulation protein B4918_29660 ENOG4105DY9 regulatoR B4918_29680 ENOG4106778 Protein of unknown function (DUF1146) B4918_29685 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B4918_29690 ENOG4105C8S subunit m B4918_29695 ENOG4105D65 subunit l B4918_29720 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) B4918_29725 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B4918_29735 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain B4918_29740 ENOG4105BZU Histidine kinase B4918_29795 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) B4918_29800 ENOG41062M3 atp synthase B4918_29825 ENOG4108UIC UPF0340 protein B4918_29830 ENOG4108YZG isomerase B4918_29850 ENOG4108VGI doxx family B4918_29855 ENOG4107XC4 flavin reductase domain protein, FMN-binding B4918_29875 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B4918_29885 ENOG4108ZXQ stage ii sporulation protein r B4918_29890 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B4918_29895 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B4918_29915 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B4918_29920 ENOG4105CBT Fructose-1,6-bisphosphatase B4918_29930 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B4918_29970 ENOG4105C1G acyl-Coa dehydrogenase B4918_29975 ENOG4105C1G acyl-Coa dehydrogenase B4918_29980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B4918_29990 ENOG4105DF6 Fe-S oxidoreductase B4918_30005 ENOG4105BZU Histidine kinase B4918_30030 ENOG4105BZU Histidine kinase B4918_30035 ENOG4105KCT ABC transporter B4918_30040 ENOG4108M15 ABC transporter B4918_30045 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B4918_30055 ENOG4105IIU Aminopeptidase B4918_30080 ENOG410684U Domain of unknown function (DUF1934) B4918_30105 ENOG4105CYW agmatinase B4918_30115 ENOG4105DXB Major Facilitator superfamily B4918_30120 ENOG4107SWG transcriptional regulator MERR family B4918_30125 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B4918_30130 ENOG4105BZ4 penicillin-binding protein B4918_30135 ENOG4108XFG YwhD family B4918_30140 ENOG4108Z4T Peptidase M50 B4918_30145 ENOG41069HH 4-oxalocrotonate tautomerase B4918_30150 ENOG4105DCI Phosphohydrolase B4918_30155 ENOG4108MES Periplasmic binding protein B4918_30160 ENOG4105E0A ABC, transporter B4918_30165 ENOG4105EHG Permease protein B4918_30170 ENOG4105DQ5 transport system permease protein B4918_30180 ENOG4108VCI transcription factor, rsfa family B4918_30185 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) B4918_30190 ENOG4108IJ2 phosphate acetyltransferase B4918_30195 ENOG4107UEZ chlorite dismutase B4918_30205 ENOG4108VKI Cell wall hydrolase B4918_30225 ENOG4107SVH Potassium channel protein B4918_30235 ENOG410667J hydrolase B4918_30240 ENOG4105VCH membrane B4918_30250 ENOG4108TU7 Inherit from COG: (ABC) transporter B4918_30255 ENOG4105CJ1 ABC, transporter B4918_30260 ENOG41090WU lipolytic protein G-D-S-L family B4918_30275 ENOG4105D6E homoserine dehydrogenase B4918_30295 ENOG4108Y4K DNA-binding transcriptional activator B4918_30305 ENOG4105WH1 Two component transcriptional regulator luxr family B4918_30310 ENOG4105BZU Histidine kinase B4918_30315 ENOG4105DWF phosphomethylpyrimidine kinase B4918_30320 ENOG4105BZU Histidine kinase B4918_30325 ENOG4105VCD cytoplasmic protein B4918_30330 ENOG4105D22 carbon starvation protein B4918_30335 ENOG4105DY9 regulatoR B4918_30340 ENOG41079KZ Major Facilitator Superfamily B4918_30355 ENOG4105CG5 Glycosyl transferase (Group 1 B4918_30365 ENOG4105EN6 Membrane B4918_30370 ENOG4106YBV Methyl-accepting chemotaxis B4918_30380 ENOG4108S4H thioesterase Superfamily protein B4918_30385 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) B4918_30400 ENOG4105K64 Glycosyl transferase, family 2 B4918_30410 ENOG4105EJV Membrane B4918_30415 ENOG4105CKK Glycosyl transferase, family 2 B4918_30425 ENOG4108IG5 Transcriptional regulator B4918_30430 ENOG4105C5H ABC transporter B4918_30435 ENOG41067SE Tetr family transcriptional regulator B4918_30445 ENOG4105E0X reductase B4918_30450 ENOG4106F5Q Membrane B4918_30465 ENOG4108NEV two component transcriptional regulator, LytTR family B4918_30470 ENOG4108HRK Histidine kinase B4918_30475 ENOG4107RGD Major Facilitator superfamily B4918_30495 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B4918_30505 ENOG4105IW1 AmiS UreI transporter B4918_30520 ENOG4105CMR udp-glucose 4-epimerase B4918_30525 ENOG4108UT2 hemolysin iii B4918_30535 ENOG4105C1J atp-dependent rna helicase B4918_30540 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) B4918_30545 ENOG4105DPN Oligoendopeptidase f B4918_30560 ENOG4105BZU Histidine kinase B4918_30575 ENOG4105C0H protease B4918_30580 ENOG4105Q2H domain protein B4918_30595 ENOG4105BZU Histidine kinase B4918_30600 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B4918_30625 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B4918_30630 ENOG4105CDU Replicative dna helicase B4918_30640 ENOG4105BZR domain protein B4918_30645 ENOG4108XMW Membrane B4918_30655 ENOG4108UUM single-stranded DNA-binding protein B4918_30665 ENOG4105C3G gtp-binding protein B4918_30670 ENOG4105VDK protein, conserved in bacteria B4918_30675 ENOG4105D8X mechanosensitive ion channel B4918_30680 ENOG4108ZDA Sporulation protein YyaC B4918_30685 ENOG4105FA0 parb-like partition protein B4918_30690 ENOG4107QJE Chromosome Partitioning Protein B4918_30710 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B4918_30720 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins B4918_30750 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) B4918_30795 ENOG4108N0N Phage Terminase Large Subunit B4918_30925 ENOG41085W3 Transposase B4918_30935 ENOG410907Z n-acetylmuramoyl-l-alanine amidase B4918_31010 ENOG41067QW Transcriptional regulator B4918_31145 ENOG4105KRN Transcriptional regulator, abrb family B4918_31325 ENOG4106CGH Phage Mu protein F like protein B4918_31330 ENOG4108MDF Phage Portal Protein B4918_31345 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_31415 ENOG4105EKQ RNA-directed DNA polymerase B4918_31475 ENOG4105CFF transcriptional regulator B4918_31495 ENOG4108IBT Inherit from COG: transposase B4918_31515 ENOG4105D9P serine threonine protein kinase B4918_31575 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) B4918_31655 ENOG4105K70 DNA-binding protein B4918_31670 ENOG4107JM4 Tetratricopeptide repeat B4918_31700 ENOG4105CAQ asparagine synthetase B4918_31705 ENOG4108RZE Tetr family transcriptional regulator B4918_31715 ENOG4108IBT Inherit from COG: transposase B4918_31740 ENOG4105D7V transposase B4918_31765 ENOG4107JM4 Tetratricopeptide repeat B4918_31775 ENOG4105YWU small acid-soluble spore protein B4918_31880 ENOG4105EKQ RNA-directed DNA polymerase B4918_31920 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B4918_31925 ENOG4105VIZ double-strand break repair protein B4918_31975 ENOG4105CNU cell division protein FtsK B4918_32175 ENOG4105EKQ RNA-directed DNA polymerase B4918_32235 ENOG4105DHF Membrane B4918_32335 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B4918_32375 ENOG4105EKQ RNA-directed DNA polymerase B4918_32405 ENOG4105KRN Transcriptional regulator, abrb family B4918_32410 ENOG4108J59 Extracellular solute-binding protein, family 5 B4918_32425 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B4918_32440 ENOG4108IBT Inherit from COG: transposase B4918_32505 ENOG4108MES Periplasmic binding protein B4918_32515 ENOG4105C8Q Methyl-accepting chemotaxis B4918_32520 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_32530 ENOG4108BSC Methyltransferase B4918_32535 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein B4918_32540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B4918_32545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B4918_32550 ENOG4105C3U ABC transporter B4918_32555 ENOG4108JQ7 (ABC) transporter B4918_32575 ENOG4105ES4 Nitrilase B4918_32585 ENOG4107RF6 penicillin-binding protein B4918_32620 ENOG4105T38 integral membrane protein B4918_32625 ENOG4107VMI polysaccharide deacetylase B4918_32655 ENOG4105EJQ L-serine dehydratase B4918_32660 ENOG4105C44 Serine transporter B4918_32690 ENOG4105C8Q Methyl-accepting chemotaxis B4918_32710 ENOG4105F6S Spore photoproduct lyase B4918_32790 ENOG4107QHE Choloylglycine hydrolase B4918_32795 ENOG4105FQP Beta-lactamase B4918_32800 ENOG4105CNI cell division protein FtsW B4918_32810 ENOG4105CJW magnesium transporter B4918_32880 ENOG4105D13 transposase B4918_32900 ENOG4107ZTW SNARE associated Golgi B4918_32915 ENOG4108D32 Methyltransferase B4918_32950 ENOG4105EKQ RNA-directed DNA polymerase B4918_32995 ENOG4105NCW Trka-c domain protein B4918_33000 ENOG4107S91 Sodium hydrogen exchanger B4918_33005 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_33050 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B4918_33080 ENOG4105XSJ toxin secretion phage lysis holin B4918_33110 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B4918_33120 ENOG4107DUR UPF0457 protein B4918_33215 ENOG4105K70 DNA-binding protein B4918_33275 ENOG4105DQ6 Transposase B4918_33335 ENOG4105EKQ RNA-directed DNA polymerase B4918_33345 ENOG4105EKQ RNA-directed DNA polymerase