locus-tag	class	description
B4918_00010	COG0592	DNA-directed DNA polymerase activity
B4918_00015	COG2501	S4 domain
B4918_00025	COG0187	DNA topoisomerase II activity
B4918_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4918_00065	COG0516	GMP reductase activity
B4918_00065	COG0517	IMP dehydrogenase activity
B4918_00070	COG1686	Belongs to the peptidase S11 family
B4918_00100	COG1428	Deoxynucleoside kinase
B4918_00105	COG1428	Deoxynucleoside kinase
B4918_00110	COG1335	isochorismatase
B4918_00120	COG0590	tRNA wobble adenosine to inosine editing
B4918_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4918_00185	COG1982	Orn Lys Arg decarboxylase major
B4918_00195	COG0470	DNA polymerase III
B4918_00200	COG1774	PSP1 C-terminal conserved region
B4918_00210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4918_00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4918_00225	COG2002	toxin-antitoxin pair type II binding
B4918_00235	COG0084	hydrolase, TatD family'
B4918_00255	COG4466	Protein conserved in bacteria
B4918_00270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4918_00280	COG0251	oxidation-reduction process
B4918_00295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4918_00310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4918_00315	COG2002	toxin-antitoxin pair type II binding
B4918_00320	COG2244	polysaccharide biosynthetic process
B4918_00325	COG3956	TIGRFAM MazG family protein
B4918_00330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4918_00350	COG1098	S1 RNA binding domain
B4918_00365	COG2208	phosphoserine phosphatase activity
B4918_00380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4918_00395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4918_00400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4918_00405	COG0512	Glutamine amidotransferase of anthranilate synthase
B4918_00410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4918_00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4918_00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4918_00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4918_00430	COG1396	sequence-specific DNA binding
B4918_00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4918_00525	COG3880	PFAM UvrB UvrC protein
B4918_00535	COG0542	response to heat
B4918_00540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4918_00550	COG4956	integral membrane protein (PIN domain superfamily)
B4918_00570	COG1045	serine acetyltransferase
B4918_00585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4918_00590	COG3688	RNA-binding protein containing a PIN domain
B4918_00600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4918_00605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4918_00610	COG0250	Participates in transcription elongation, termination and antitermination
B4918_00635	COG2813	Specifically methylates the guanine in position
B4918_00650	COG1358	cellular component organization or biogenesis
B4918_00760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4918_00785	COG0201	protein transport
B4918_00795	COG0024	Methionine aminopeptidase
B4918_00805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4918_00840	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4918_00865	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4918_00870	COG0489	protein tyrosine kinase activity
B4918_00880	COG2194	sulfuric ester hydrolase activity
B4918_00885	COG0726	polysaccharide deacetylase
B4918_00965	COG0010	Belongs to the arginase family
B4918_00975	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4918_00980	COG4856	YbbR-like protein
B4918_01015	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_01020	COG2011	ABC-type metal ion transport system permease component
B4918_01025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4918_01030	COG1464	Belongs to the NlpA lipoprotein family
B4918_01035	COG0604	alcohol dehydrogenase
B4918_01045	COG0277	FAD linked oxidase domain protein
B4918_01050	COG2271	Major facilitator Superfamily
B4918_01060	COG2814	Major facilitator Superfamily
B4918_01080	COG0601	transmembrane transport
B4918_01085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4918_01090	COG0444	Belongs to the ABC transporter superfamily
B4918_01095	COG4608	Belongs to the ABC transporter superfamily
B4918_01100	COG4166	transmembrane transport
B4918_01120	COG4166	transmembrane transport
B4918_01125	COG0656	L-ascorbic acid biosynthetic process
B4918_01140	COG4149	molybdate abc transporter
B4918_01145	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4918_01150	COG1910	domain protein
B4918_01170	COG0697	spore germination
B4918_01185	COG0204	Acyl-transferase
B4918_01200	COG1609	Transcriptional regulator
B4918_01240	COG5298	Protein conserved in bacteria
B4918_01265	COG0488	(ABC) transporter
B4918_01280	COG0747	negative chemotaxis
B4918_01285	COG0601	transmembrane transport
B4918_01295	COG0444	Belongs to the ABC transporter superfamily
B4918_01300	COG4608	Belongs to the ABC transporter superfamily
B4918_01305	COG0561	phosphatase activity
B4918_01335	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B4918_01340	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4918_01350	COG0531	amino acid
B4918_01355	COG2814	Major facilitator Superfamily
B4918_01365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4918_01375	COG4294	response to UV
B4918_01380	COG0705	Rhomboid family
B4918_01390	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B4918_01395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4918_01400	COG0864	Transcriptional regulator
B4918_01405	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4918_01410	COG2183	response to ionizing radiation
B4918_01510	COG0802	atpase or kinase
B4918_01515	COG1214	PFAM Peptidase M22, glycoprotease
B4918_01520	COG0456	acetyltransferase
B4918_01535	COG0488	(ABC) transporter
B4918_01550	COG1266	CAAX protease self-immunity
B4918_01570	COG2252	PERMEase
B4918_01580	COG5002	protein histidine kinase activity
B4918_01610	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4918_01630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_01635	COG0506	proline dehydrogenase activity
B4918_01655	COG0697	spore germination
B4918_01685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4918_01690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4918_01695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4918_01705	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4918_01720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4918_01730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4918_01740	COG0151	Belongs to the GarS family
B4918_01765	COG0210	DNA helicase
B4918_01775	COG4851	CamS sex pheromone cAM373 precursor
B4918_01790	COG1335	isochorismatase
B4918_01800	COG2011	ABC-type metal ion transport system permease component
B4918_01805	COG1464	Belongs to the NlpA lipoprotein family
B4918_01810	COG4682	membrane
B4918_01830	COG1597	lipid kinase activity
B4918_01840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B4918_01850	COG1012	belongs to the aldehyde dehydrogenase family
B4918_01855	COG2076	Multidrug Resistance protein
B4918_01865	COG2309	aminopeptidase activity
B4918_01880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4918_01890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4918_01895	COG4807	Protein conserved in bacteria
B4918_01930	COG1473	amidohydrolase
B4918_01945	COG0450	alkyl hydroperoxide reductase
B4918_01950	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B4918_01960	COG0235	Class ii aldolase
B4918_01965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_01970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_01975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_02000	COG0166	Belongs to the GPI family
B4918_02030	COG5002	protein histidine kinase activity
B4918_02050	COG3541	Predicted nucleotidyltransferase
B4918_02055	COG2814	Major facilitator Superfamily
B4918_02060	COG0723	plastoquinol--plastocyanin reductase activity
B4918_02060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4918_02070	COG0765	amino acid transport
B4918_02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4918_02080	COG1126	abc transporter atp-binding protein
B4918_02085	COG0840	transmembrane signaling receptor activity
B4918_02110	COG0549	Belongs to the carbamate kinase family
B4918_02115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4918_02125	COG0277	FAD linked oxidase domain protein
B4918_02130	COG0366	Alpha amylase catalytic
B4918_02135	COG2190	(PTS) system
B4918_02135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4918_02135	COG1263	PTS System
B4918_02165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
B4918_02185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4918_02190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4918_02195	COG1116	anion transmembrane transporter activity
B4918_02200	COG0488	(ABC) transporter
B4918_02250	COG2270	Major facilitator Superfamily
B4918_02280	COG2310	stress, protein
B4918_02285	COG2310	stress, protein
B4918_02290	COG2310	stress, protein
B4918_02295	COG0861	Integral membrane protein TerC family
B4918_02305	COG3853	Toxic anion resistance protein (TelA)
B4918_02320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4918_02330	COG1295	ribonuclease BN
B4918_02340	COG2217	Heavy metal translocating P-type atpase
B4918_02345	COG0697	spore germination
B4918_02365	COG0586	Pfam SNARE associated Golgi protein
B4918_02385	COG0387	Pfam Sodium calcium exchanger
B4918_02395	COG0535	radical SAM domain protein
B4918_02415	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4918_02420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4918_02445	COG3829	transcription factor binding
B4918_02455	COG0833	amino acid
B4918_02460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4918_02490	COG2066	Belongs to the glutaminase family
B4918_02500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4918_02500	COG1263	PTS System
B4918_02510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4918_02525	COG1216	Glycosyl transferase, family 2
B4918_02535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4918_02535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4918_02540	COG0463	Glycosyl transferase, family 2
B4918_02555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
B4918_02575	COG1228	amidohydrolase
B4918_02580	COG1090	epimerase
B4918_02610	COG1988	membrane-bound metal-dependent
B4918_02615	COG1194	a g-specific adenine glycosylase
B4918_02640	COG1132	(ABC) transporter
B4918_02645	COG4129	membrane
B4918_02650	COG0067	glutamate synthase
B4918_02650	COG0069	glutamate synthase activity
B4918_02650	COG0070	glutamate synthase
B4918_02660	COG4555	ABC transporter
B4918_02680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4918_02685	COG0735	belongs to the Fur family
B4918_02840	COG4974	Belongs to the 'phage' integrase family
B4918_02875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B4918_02900	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4918_02915	COG2766	serine protein kinase
B4918_02935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4918_02945	COG1585	Membrane protein implicated in regulation of membrane protease activity
B4918_02950	COG2268	Band 7 protein
B4918_02960	COG3290	protein histidine kinase activity
B4918_02965	COG4565	transcriptional regulatory protein
B4918_02970	COG2851	Citrate transporter
B4918_02995	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4918_03000	COG3842	ATPase activity
B4918_03005	COG1175	transmembrane transport
B4918_03010	COG0395	ABC-type sugar transport system, permease component
B4918_03020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4918_03025	COG0745	RESPONSE REGULATOR receiver
B4918_03030	COG5002	protein histidine kinase activity
B4918_03040	COG4990	cell redox homeostasis
B4918_03050	COG3290	protein histidine kinase activity
B4918_03055	COG4565	transcriptional regulatory protein
B4918_03060	COG3493	citrate carrier protein
B4918_03065	COG0281	malic enzyme
B4918_03080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_03090	COG5002	protein histidine kinase activity
B4918_03120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B4918_03125	COG3383	formate dehydrogenase (NAD+) activity
B4918_03130	COG2427	Protein of unknown function (DUF1641)
B4918_03145	COG0531	amino acid
B4918_03150	COG0640	Transcriptional regulator
B4918_03155	COG2217	Heavy metal translocating P-type atpase
B4918_03160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4918_03175	COG3227	Zinc metalloprotease (Elastase)
B4918_03195	COG2720	vancomycin resistance protein
B4918_03200	COG1316	TRANSCRIPTIONal
B4918_03205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4918_03210	COG0346	lactoylglutathione lyase activity
B4918_03215	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_03225	COG1253	flavin adenine dinucleotide binding
B4918_03230	COG1027	Aspartate ammonia-lyase
B4918_03235	COG1620	l-lactate permease
B4918_03250	COG3104	oligopeptide transport
B4918_03255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_03260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_03265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_03280	COG0156	8-amino-7-oxononanoate synthase activity
B4918_03285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4918_03295	COG4548	von Willebrand factor, type A
B4918_03300	COG0714	Associated with various cellular activities
B4918_03320	COG0531	amino acid
B4918_03325	COG2188	Transcriptional regulator
B4918_03330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4918_03330	COG1263	PTS System
B4918_03335	COG0366	Alpha amylase catalytic
B4918_03350	COG0697	spore germination
B4918_03355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4918_03360	COG1115	amino acid carrier protein
B4918_03370	COG1126	abc transporter atp-binding protein
B4918_03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4918_03380	COG0765	amino acid transport
B4918_03385	COG0765	amino acid transport
B4918_03390	COG0833	amino acid
B4918_03405	COG1595	DNA-templated transcription, initiation
B4918_03415	COG2378	regulation of single-species biofilm formation
B4918_03420	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4918_03425	COG5002	protein histidine kinase activity
B4918_03440	COG0659	secondary active sulfate transmembrane transporter activity
B4918_03455	COG2271	Major facilitator Superfamily
B4918_03460	COG1846	Transcriptional regulator
B4918_03465	COG0477	Major facilitator Superfamily
B4918_03470	COG1609	Transcriptional regulator
B4918_03475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4918_03490	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4918_03495	COG1879	ABC-type sugar transport system periplasmic component
B4918_03500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4918_03525	COG1063	alcohol dehydrogenase
B4918_03575	COG0840	transmembrane signaling receptor activity
B4918_03580	COG3583	domain protein
B4918_03580	COG3584	3D domain protein
B4918_03585	COG1476	TRANSCRIPTIONal
B4918_03605	COG3104	oligopeptide transport
B4918_03610	COG1114	Component of the transport system for branched-chain amino acids
B4918_03625	COG1113	amino acid transport
B4918_03630	COG2252	PERMEase
B4918_03645	COG2153	protein acetylation
B4918_03655	COG0475	glutathione-regulated potassium exporter activity
B4918_03655	COG0569	domain protein
B4918_03670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4918_03675	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4918_03680	COG0833	amino acid
B4918_03685	COG4990	cell redox homeostasis
B4918_03700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4918_03705	COG0697	spore germination
B4918_03710	COG0531	amino acid
B4918_03725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4918_03730	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4918_03735	COG1918	ferrous iron import across plasma membrane
B4918_03735	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4918_03740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4918_03745	COG0573	inorganic phosphate transmembrane transporter activity
B4918_03750	COG0581	inorganic phosphate transmembrane transporter activity
B4918_03760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4918_03880	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B4918_03905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4918_03910	COG1116	anion transmembrane transporter activity
B4918_03915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4918_03920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4918_03925	COG0352	thiamine-phosphate diphosphorylase activity
B4918_03930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4918_03935	COG2104	thiamine diphosphate biosynthetic process
B4918_03945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4918_03950	COG0351	phosphomethylpyrimidine kinase
B4918_03990	COG2205	protein histidine kinase activity
B4918_03995	COG2814	Major facilitator Superfamily
B4918_04000	COG1846	Transcriptional regulator
B4918_04025	COG1136	(ABC) transporter
B4918_04035	COG2252	PERMEase
B4918_04040	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_04100	COG0778	Nitroreductase
B4918_04105	COG2719	SpoVR family
B4918_04125	COG1937	Protein conserved in bacteria
B4918_04130	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4918_04130	COG0425	Belongs to the sulfur carrier protein TusA family
B4918_04135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4918_04135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_04140	COG0425	Belongs to the sulfur carrier protein TusA family
B4918_04145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4918_04145	COG0425	Belongs to the sulfur carrier protein TusA family
B4918_04150	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4918_04155	COG2210	Belongs to the sulfur carrier protein TusA family
B4918_04160	COG0730	response to heat
B4918_04170	COG1316	TRANSCRIPTIONal
B4918_04175	COG0604	alcohol dehydrogenase
B4918_04180	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4918_04195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4918_04195	COG3711	transcriptional antiterminator
B4918_04200	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4918_04205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4918_04230	COG1388	LysM domain
B4918_04230	COG3584	3D domain protein
B4918_04235	COG0577	efflux transmembrane transporter activity
B4918_04240	COG1136	(ABC) transporter
B4918_04250	COG5522	Integral membrane protein (intg_mem_TP0381)
B4918_04265	COG1114	Component of the transport system for branched-chain amino acids
B4918_04270	COG3546	catalase activity
B4918_04305	COG0586	Pfam SNARE associated Golgi protein
B4918_04340	COG0531	amino acid
B4918_04345	COG0475	glutathione-regulated potassium exporter activity
B4918_04355	COG1737	Transcriptional regulator
B4918_04365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4918_04365	COG1263	PTS System
B4918_04375	COG2259	Doxx family
B4918_04395	COG1522	sequence-specific DNA binding
B4918_04405	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_04410	COG0789	Transcriptional regulator
B4918_04415	COG2076	Multidrug Resistance protein
B4918_04425	COG1309	transcriptional regulator
B4918_04430	COG2814	Major facilitator Superfamily
B4918_04435	COG1733	regulation of RNA biosynthetic process
B4918_04455	COG0693	protein deglycase activity
B4918_04460	COG0753	catalase activity
B4918_04460	COG0693	protein deglycase activity
B4918_04470	COG0531	amino acid
B4918_04475	COG1012	belongs to the aldehyde dehydrogenase family
B4918_04490	COG1132	(ABC) transporter
B4918_04495	COG1132	(ABC) transporter
B4918_04505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4918_04510	COG0765	amino acid transport
B4918_04515	COG1126	abc transporter atp-binding protein
B4918_04530	COG0189	ligase activity
B4918_04560	COG0028	Belongs to the TPP enzyme family
B4918_04565	COG3527	Alpha-acetolactate decarboxylase
B4918_04575	COG0561	phosphatase activity
B4918_04585	COG3409	Peptidoglycan-binding domain 1 protein
B4918_04585	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_04590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4918_04595	COG0318	PFAM AMP-dependent synthetase and ligase
B4918_04605	COG0659	secondary active sulfate transmembrane transporter activity
B4918_04610	COG2244	polysaccharide biosynthetic process
B4918_04630	COG1024	Enoyl-CoA hydratase
B4918_04650	COG1363	Peptidase, m42
B4918_04685	COG0601	transmembrane transport
B4918_04690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4918_04695	COG0444	Belongs to the ABC transporter superfamily
B4918_04700	COG4608	Belongs to the ABC transporter superfamily
B4918_04730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_04750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4918_04765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4918_04770	COG2814	Major facilitator Superfamily
B4918_04805	COG2801	Transposase and inactivated derivatives
B4918_04810	COG0477	Major facilitator Superfamily
B4918_04815	COG3290	protein histidine kinase activity
B4918_04820	COG4565	transcriptional regulatory protein
B4918_04825	COG3181	Tripartite tricarboxylate transporter family receptor
B4918_04860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B4918_04870	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B4918_04880	COG0210	DNA helicase
B4918_04885	COG0210	DNA helicase
B4918_04905	COG0642	Histidine kinase
B4918_04920	COG0270	DNA (cytosine-5-)-methyltransferase activity
B4918_04930	COG0305	Participates in initiation and elongation during chromosome replication
B4918_04960	COG0477	Major facilitator Superfamily
B4918_04980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_05000	COG2801	Transposase and inactivated derivatives
B4918_05030	COG1073	alpha beta
B4918_05100	COG1183	phosphatidylcholine synthase activity
B4918_05110	COG2814	Major facilitator Superfamily
B4918_05115	COG0640	Transcriptional regulator
B4918_05130	COG2376	Dihydroxyacetone kinase
B4918_05140	COG2376	Dihydroxyacetone kinase
B4918_05185	COG2373	Large extracellular alpha-helical protein
B4918_05255	COG1191	sigma factor activity
B4918_05265	COG2208	phosphoserine phosphatase activity
B4918_05270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4918_05320	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B4918_05340	COG0420	3'-5' exonuclease activity
B4918_05345	COG4717	serine-type aminopeptidase activity
B4918_05365	COG1280	lysine exporter protein (LysE YggA)
B4918_05370	COG0346	lactoylglutathione lyase activity
B4918_05375	COG0346	lactoylglutathione lyase activity
B4918_05380	COG0457	Tetratricopeptide repeat
B4918_05390	COG2267	carboxylic ester hydrolase activity
B4918_05405	COG2140	Oxalate decarboxylase
B4918_05410	COG3620	sequence-specific DNA binding
B4918_05415	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4918_05420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4918_05430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4918_05455	COG3973	AAA domain
B4918_05485	COG4980	gas vesicle protein
B4918_05490	COG0537	adenosine 5'-monophosphoramidase activity
B4918_05500	COG1131	(ABC) transporter
B4918_05505	COG4473	ABC transporter
B4918_05515	COG1309	transcriptional regulator
B4918_05525	COG3402	PFAM membrane-flanked domain
B4918_05530	COG3428	Bacterial PH domain
B4918_05565	COG0697	spore germination
B4918_05570	COG3402	PFAM membrane-flanked domain
B4918_05575	COG3428	Bacterial PH domain
B4918_05580	COG2329	Antibiotic biosynthesis monooxygenase
B4918_05585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4918_05625	COG1309	transcriptional regulator
B4918_05630	COG1511	domain protein
B4918_05655	COG1609	Transcriptional regulator
B4918_05665	COG1234	tRNA 3'-trailer cleavage
B4918_05670	COG0095	Lipoate-protein ligase
B4918_05680	COG0318	PFAM AMP-dependent synthetase and ligase
B4918_05720	COG1073	alpha beta
B4918_05725	COG1408	metallophosphoesterase
B4918_05730	COG1078	dGTPase activity
B4918_05745	COG1595	DNA-templated transcription, initiation
B4918_05750	COG2207	Transcriptional regulator
B4918_05750	COG3708	Transcriptional regulator
B4918_05765	COG2205	protein histidine kinase activity
B4918_05770	COG0745	RESPONSE REGULATOR receiver
B4918_05790	COG0501	Belongs to the peptidase M48B family
B4918_05795	COG0840	transmembrane signaling receptor activity
B4918_05805	COG3693	PFAM glycoside hydrolase, family 10
B4918_05815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B4918_05820	COG2224	Isocitrate lyase
B4918_05835	COG1278	Cold shock
B4918_05850	COG4903	ComK protein
B4918_05855	COG0398	Pfam SNARE associated Golgi protein
B4918_05915	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4918_05940	COG0367	asparagine synthase
B4918_06160	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_06185	COG0367	asparagine synthase
B4918_06195	COG0753	catalase activity
B4918_06200	COG0004	ammonium transporteR
B4918_06220	COG2996	Protein conserved in bacteria
B4918_06235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_06250	COG0561	phosphatase activity
B4918_06275	COG2267	carboxylic ester hydrolase activity
B4918_06290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4918_06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4918_06300	COG5504	Zn-dependent protease
B4918_06315	COG0180	Tryptophanyl-tRNA synthetase
B4918_06330	COG4166	transmembrane transport
B4918_06335	COG0601	transmembrane transport
B4918_06340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4918_06345	COG0444	Belongs to the ABC transporter superfamily
B4918_06350	COG4608	Belongs to the ABC transporter superfamily
B4918_06355	COG0534	Mate efflux family protein
B4918_06360	COG4166	transmembrane transport
B4918_06380	COG1393	Belongs to the ArsC family
B4918_06385	COG0861	Integral membrane protein TerC family
B4918_06395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4918_06405	COG1164	Oligoendopeptidase f
B4918_06420	COG2346	COG2346, Truncated hemoglobins
B4918_06425	COG4116	CYTH
B4918_06435	COG2357	RelA SpoT domain protein
B4918_06445	COG0564	pseudouridine synthase activity
B4918_06460	COG0772	Belongs to the SEDS family
B4918_06465	COG1216	Glycosyl transferase, family 2
B4918_06485	COG0457	Tetratricopeptide repeat
B4918_06485	COG0463	Glycosyl transferase, family 2
B4918_06505	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B4918_06520	COG1091	dTDP-4-dehydrorhamnose reductase activity
B4918_06565	COG2153	protein acetylation
B4918_06575	COG2382	esterase
B4918_06590	COG5492	domain, Protein
B4918_06595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4918_06610	COG0512	Glutamine amidotransferase of anthranilate synthase
B4918_06610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B4918_06645	COG1620	l-lactate permease
B4918_06655	COG5634	Uncharacterized conserved protein (DUF2278)
B4918_06715	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4918_06725	COG1476	TRANSCRIPTIONal
B4918_06770	COG2226	methyltransferase
B4918_06780	COG1686	Belongs to the peptidase S11 family
B4918_06785	COG0681	Belongs to the peptidase S26 family
B4918_06815	COG1012	belongs to the aldehyde dehydrogenase family
B4918_06825	COG1176	ABC-type spermidine putrescine transport system, permease component I
B4918_06830	COG1177	transmembrane transport
B4918_06835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B4918_06840	COG0671	phosphoesterase, PA-phosphatase related
B4918_06845	COG2409	Drug exporters of the RND superfamily
B4918_06855	COG0564	pseudouridine synthase activity
B4918_06865	COG2340	Cysteine-rich secretory protein family
B4918_06870	COG0247	lactate metabolic process
B4918_06875	COG0277	FAD linked oxidase domain protein
B4918_06880	COG3835	regulator
B4918_06890	COG0745	RESPONSE REGULATOR receiver
B4918_06895	COG5002	protein histidine kinase activity
B4918_06900	COG2186	Transcriptional regulator
B4918_06920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4918_06930	COG2116	formate transmembrane transporter activity
B4918_06935	COG0861	Integral membrane protein TerC family
B4918_06940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4918_06950	COG2030	dehydratase
B4918_06970	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_06975	COG3243	poly(R)-hydroxyalkanoic acid synthase
B4918_06985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4918_07005	COG1840	ABC-type Fe3 transport system, periplasmic component
B4918_07010	COG3842	ATPase activity
B4918_07035	COG1349	DNA-binding transcription factor activity
B4918_07050	COG0235	Class ii aldolase
B4918_07060	COG2861	carbohydrate metabolic process
B4918_07070	COG3852	Histidine kinase
B4918_07075	COG1846	Transcriptional regulator
B4918_07085	COG2318	DinB family
B4918_07095	COG5002	protein histidine kinase activity
B4918_07105	COG0720	synthase
B4918_07120	COG4873	Protein conserved in bacteria
B4918_07160	COG1780	Probably involved in ribonucleotide reductase function
B4918_07165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4918_07170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4918_07175	COG1725	Transcriptional regulator
B4918_07180	COG1131	(ABC) transporter
B4918_07190	COG1131	(ABC) transporter
B4918_07195	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4918_07210	COG1522	sequence-specific DNA binding
B4918_07220	COG1335	isochorismatase
B4918_07230	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4918_07235	COG2070	2-Nitropropane dioxygenase
B4918_07240	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4918_07250	COG1696	Membrane protein involved in D-alanine export
B4918_07275	COG0716	FMN binding
B4918_07335	COG1846	Transcriptional regulator
B4918_07345	COG1301	dicarboxylic acid transport
B4918_07350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4918_07355	COG4709	membrane
B4918_07360	COG3874	Sporulation protein YtfJ
B4918_07390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4918_07395	COG0028	Belongs to the TPP enzyme family
B4918_07400	COG0440	acetolactate synthase activity
B4918_07475	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4918_07490	COG1183	phosphatidylcholine synthase activity
B4918_07495	COG1368	sulfuric ester hydrolase activity
B4918_07500	COG0582	viral genome integration into host DNA
B4918_07515	COG1396	sequence-specific DNA binding
B4918_07525	COG3645	SOS response
B4918_07525	COG3646	Phage regulatory protein
B4918_07570	COG2002	toxin-antitoxin pair type II binding
B4918_07665	COG0582	viral genome integration into host DNA
B4918_07710	COG4626	Terminase
B4918_07710	COG1802	Transcriptional regulator
B4918_07720	COG0740	serine-type endopeptidase activity
B4918_07790	COG4824	toxin secretion phage lysis holin
B4918_07795	COG1388	LysM domain
B4918_07795	COG3409	Peptidoglycan-binding domain 1 protein
B4918_07795	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_07815	COG0019	diaminopimelate decarboxylase activity
B4918_07835	COG0529	Catalyzes the synthesis of activated sulfate
B4918_07840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4918_07860	COG1648	precorrin-2 dehydrogenase activity
B4918_07870	COG0733	neurotransmitter:sodium symporter activity
B4918_07890	COG1757	Na H antiporter
B4918_07905	COG4758	membrane
B4918_07910	COG4585	Histidine kinase
B4918_07915	COG2197	response regulator
B4918_07925	COG1114	Component of the transport system for branched-chain amino acids
B4918_07980	COG0730	response to heat
B4918_07985	COG0306	phosphate transporter
B4918_07990	COG1392	Phosphate transport regulator
B4918_07995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4918_08010	COG3852	Histidine kinase
B4918_08015	COG1801	Protein of unknown function DUF72
B4918_08025	COG0582	viral genome integration into host DNA
B4918_08030	COG5002	protein histidine kinase activity
B4918_08045	COG0392	lysyltransferase activity
B4918_08045	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4918_08060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4918_08065	COG1686	Belongs to the peptidase S11 family
B4918_08070	COG2715	membrane protein required for spore maturation
B4918_08075	COG0700	Nucleoside recognition
B4918_08080	COG1187	pseudouridine synthase activity
B4918_08090	COG1333	cytochrome c biogenesis protein
B4918_08095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4918_08100	COG0745	RESPONSE REGULATOR receiver
B4918_08105	COG5002	protein histidine kinase activity
B4918_08110	COG2096	Adenosyltransferase
B4918_08125	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B4918_08130	COG1141	Ferredoxin
B4918_08140	COG0514	ATP-dependent DNA helicase (RecQ)
B4918_08145	COG1266	CAAX protease self-immunity
B4918_08155	COG1408	metallophosphoesterase
B4918_08160	COG0789	Transcriptional regulator
B4918_08170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4918_08190	COG0492	ferredoxin-NADP+ reductase activity
B4918_08195	COG0252	asparaginase activity
B4918_08265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4918_08280	COG0142	geranyltranstransferase activity
B4918_08290	COG0142	geranyltranstransferase activity
B4918_08320	COG0457	Tetratricopeptide repeat
B4918_08340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4918_08345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4918_08345	COG2010	Cytochrome c
B4918_08350	COG4347	Protein of unknown function (DUF1405)
B4918_08365	COG2738	Putative neutral zinc metallopeptidase
B4918_08375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_08380	COG1694	Mazg nucleotide pyrophosphohydrolase
B4918_08400	COG0438	transferase activity, transferring glycosyl groups
B4918_08440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4918_08440	COG1199	ATP-dependent helicase activity
B4918_08460	COG3935	DnaD domain protein
B4918_08465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4918_08475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4918_08475	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4918_08535	COG0116	Belongs to the methyltransferase superfamily
B4918_08545	COG1199	ATP-dependent helicase activity
B4918_08550	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4918_08560	COG3173	Aminoglycoside phosphotransferase
B4918_08565	COG0024	Methionine aminopeptidase
B4918_08575	COG2233	PERMEase
B4918_08580	COG2311	Membrane
B4918_08590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4918_08600	COG0456	acetyltransferase
B4918_08635	COG0754	glutathionylspermidine amidase activity
B4918_08650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4918_08675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4918_08690	COG1215	transferase activity, transferring glycosyl groups
B4918_08695	COG0438	transferase activity, transferring glycosyl groups
B4918_08710	COG0454	-acetyltransferase
B4918_08730	COG0328	RNA-DNA hybrid ribonuclease activity
B4918_08765	COG3403	YqcI/YcgG family
B4918_08770	COG1280	lysine exporter protein (LysE YggA)
B4918_08790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4918_08795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4918_08805	COG0475	glutathione-regulated potassium exporter activity
B4918_08810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4918_08815	COG0789	Transcriptional regulator
B4918_08815	COG4978	Transcriptional regulator
B4918_08825	COG2323	membrane
B4918_08830	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B4918_08865	COG1923	regulation of RNA biosynthetic process
B4918_08875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4918_08880	COG1360	Flagellar Motor Protein
B4918_08885	COG2201	protein-glutamate methylesterase activity
B4918_08890	COG0643	Histidine kinase
B4918_08890	COG2198	Histidine kinase
B4918_08895	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4918_08895	COG1776	CheC inhibitor of MCP methylation
B4918_08910	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4918_08930	COG1256	bacterial-type flagellum assembly
B4918_08935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4918_08960	COG1815	bacterial-type flagellum-dependent cell motility
B4918_08965	COG1558	bacterial-type flagellum-dependent cell motility
B4918_08970	COG1677	Flagellar hook-basal body complex protein FliE
B4918_08975	COG1766	The M ring may be actively involved in energy transduction
B4918_08980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4918_08990	COG1157	protein secretion by the type III secretion system
B4918_09010	COG1749	Flagellar hook protein flgE
B4918_09025	COG0784	Response regulator, receiver
B4918_09025	COG0835	chemotaxis
B4918_09035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4918_09040	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4918_09045	COG0741	lytic transglycosylase activity
B4918_09055	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4918_09060	COG1776	CheC inhibitor of MCP methylation
B4918_09060	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4918_09070	COG1338	Plays a role in the flagellum-specific transport system
B4918_09075	COG1987	bacterial-type flagellum assembly
B4918_09085	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4918_09090	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4918_09095	COG1419	protein localization to endoplasmic reticulum
B4918_09100	COG4786	Flagellar basal body rod
B4918_09110	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4918_09140	COG2329	Antibiotic biosynthesis monooxygenase
B4918_09175	COG3842	ATPase activity
B4918_09185	COG1177	transmembrane transport
B4918_09225	COG0406	alpha-ribazole phosphatase activity
B4918_09240	COG1846	Transcriptional regulator
B4918_09250	COG0367	asparagine synthase
B4918_09285	COG0523	cobalamin synthesis protein
B4918_09295	COG0701	Predicted permease
B4918_09305	COG1216	Glycosyl transferase, family 2
B4918_09305	COG0438	transferase activity, transferring glycosyl groups
B4918_09310	COG1757	Na H antiporter
B4918_09315	COG0789	Transcriptional regulator
B4918_09345	COG0534	Mate efflux family protein
B4918_09350	COG3340	Belongs to the peptidase S51 family
B4918_09370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4918_09540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4918_09600	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4918_09600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4918_09625	COG1484	DNA-dependent DNA replication
B4918_09660	COG2733	membrane
B4918_09700	COG1131	(ABC) transporter
B4918_09715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4918_09720	COG0528	UMP kinase activity
B4918_09730	COG1027	Aspartate ammonia-lyase
B4918_09735	COG0281	malic enzyme
B4918_09740	COG4191	Histidine kinase
B4918_09745	COG0784	Response regulator, receiver
B4918_09750	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4918_09810	COG2814	Major facilitator Superfamily
B4918_09825	COG1695	Transcriptional regulator
B4918_09835	COG0477	Major facilitator Superfamily
B4918_09845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4918_09850	COG2223	nitrite transmembrane transporter activity
B4918_09855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4918_09875	COG0733	neurotransmitter:sodium symporter activity
B4918_09885	COG5566	PFAM Mor transcription activator
B4918_09890	COG2323	membrane
B4918_09920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4918_09930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4918_09935	COG0028	Belongs to the TPP enzyme family
B4918_09955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4918_09980	COG2814	Major facilitator Superfamily
B4918_09985	COG3384	dioxygenase
B4918_10000	COG3279	Response regulator of the LytR AlgR family
B4918_10005	COG0427	acetyl-CoA hydrolase
B4918_10025	COG4166	transmembrane transport
B4918_10030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_10050	COG1914	H( )-stimulated, divalent metal cation uptake system
B4918_10065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4918_10070	COG0531	amino acid
B4918_10095	COG2309	aminopeptidase activity
B4918_10110	COG0456	acetyltransferase
B4918_10130	COG1309	transcriptional regulator
B4918_10135	COG2390	Transcriptional regulator
B4918_10145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4918_10150	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B4918_10155	COG0295	cytidine deaminase activity
B4918_10170	COG2801	Transposase and inactivated derivatives
B4918_10200	COG4846	Membrane protein involved in cytochrome C biogenesis
B4918_10210	COG0006	proline dipeptidase activity
B4918_10255	COG1595	DNA-templated transcription, initiation
B4918_10260	COG0726	polysaccharide deacetylase
B4918_10285	COG2239	Acts as a magnesium transporter
B4918_10290	COG0772	Belongs to the SEDS family
B4918_10335	COG1396	sequence-specific DNA binding
B4918_10345	COG1396	sequence-specific DNA binding
B4918_10360	COG4974	Belongs to the 'phage' integrase family
B4918_10380	COG0814	amino acid
B4918_10385	COG0697	spore germination
B4918_10390	COG0463	Glycosyl transferase, family 2
B4918_10390	COG0457	Tetratricopeptide repeat
B4918_10440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4918_10495	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4918_10500	COG1959	2 iron, 2 sulfur cluster binding
B4918_10510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4918_10540	COG3344	reverse transcriptase
B4918_10610	COG1114	Component of the transport system for branched-chain amino acids
B4918_10620	COG1276	copper resistance
B4918_10620	COG2372	response to copper ion
B4918_10625	COG4549	nuclear export factor GLE1
B4918_10630	COG0697	spore germination
B4918_10635	COG0583	DNA-binding transcription factor activity
B4918_10640	COG1959	2 iron, 2 sulfur cluster binding
B4918_10645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4918_10650	COG0778	Nitroreductase
B4918_10665	COG1396	sequence-specific DNA binding
B4918_10695	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_10770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4918_10770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4918_10860	COG2002	toxin-antitoxin pair type II binding
B4918_11075	COG0628	permease
B4918_11085	COG1231	oxidoreductase activity
B4918_11095	COG0523	cobalamin synthesis protein
B4918_11105	COG0411	ABC transporter
B4918_11115	COG0559	Belongs to the binding-protein-dependent transport system permease family
B4918_11125	COG0583	DNA-binding transcription factor activity
B4918_11135	COG1942	4-Oxalocrotonate Tautomerase
B4918_11155	COG1271	oxidase subunit
B4918_11160	COG1294	oxidase, subunit
B4918_11165	COG4988	ABC transporter
B4918_11170	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4918_11180	COG1216	Glycosyl transferase, family 2
B4918_11220	COG1686	Belongs to the peptidase S11 family
B4918_11235	COG0791	NLP P60 protein
B4918_11235	COG1388	LysM domain
B4918_11245	COG1132	(ABC) transporter
B4918_11250	COG0745	RESPONSE REGULATOR receiver
B4918_11255	COG5002	protein histidine kinase activity
B4918_11260	COG0300	oxidoreductase activity
B4918_11280	COG0726	polysaccharide deacetylase
B4918_11300	COG0460	homoserine dehydrogenase
B4918_11325	COG1316	TRANSCRIPTIONal
B4918_11345	COG1285	pathogenesis
B4918_11350	COG1247	-acetyltransferase
B4918_11360	COG4264	IucA IucC family
B4918_11365	COG0318	PFAM AMP-dependent synthetase and ligase
B4918_11380	COG1082	Xylose isomerase domain protein TIM barrel
B4918_11390	COG2814	Major facilitator Superfamily
B4918_11395	COG1279	arginine transmembrane transporter activity
B4918_11400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_11415	COG3344	reverse transcriptase
B4918_11425	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4918_11460	COG0577	efflux transmembrane transporter activity
B4918_11465	COG2002	toxin-antitoxin pair type II binding
B4918_11470	COG1404	Belongs to the peptidase S8 family
B4918_11475	COG0640	Transcriptional regulator
B4918_11480	COG0667	Aldo Keto reductase
B4918_11485	COG2814	Major facilitator Superfamily
B4918_11515	COG0840	transmembrane signaling receptor activity
B4918_11535	COG3949	Membrane
B4918_11540	COG0783	Belongs to the Dps family
B4918_11555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4918_11565	COG1231	oxidoreductase activity
B4918_11570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_11575	COG4989	oxidoreductase activity
B4918_11580	COG0523	cobalamin synthesis protein
B4918_11585	COG0456	acetyltransferase
B4918_11590	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4918_11600	COG0702	epimerase
B4918_11610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4918_11620	COG4166	transmembrane transport
B4918_11635	COG0406	alpha-ribazole phosphatase activity
B4918_11645	COG5337	Spore coat protein CotH
B4918_11650	COG1051	belongs to the nudix hydrolase family
B4918_11655	COG0586	Pfam SNARE associated Golgi protein
B4918_11660	COG2244	polysaccharide biosynthetic process
B4918_11670	COG0701	Predicted permease
B4918_11675	COG3689	TIGRFAM TIGR03943 family protein
B4918_11680	COG1607	acyl-coa hydrolase
B4918_11690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4918_11705	COG0702	epimerase
B4918_11710	COG2839	Protein conserved in bacteria
B4918_11715	COG1253	flavin adenine dinucleotide binding
B4918_11740	COG1114	Component of the transport system for branched-chain amino acids
B4918_11745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4918_11765	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4918_11775	COG1876	peptidase activity
B4918_11790	COG2211	Major facilitator Superfamily
B4918_11815	COG0561	phosphatase activity
B4918_11820	COG1846	Transcriptional regulator
B4918_11825	COG2814	Major facilitator Superfamily
B4918_11835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4918_11855	COG1819	glycosyl
B4918_11860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_11865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_11895	COG0456	acetyltransferase
B4918_12000	COG3874	Sporulation protein YtfJ
B4918_12025	COG2226	methyltransferase
B4918_12045	COG1082	Xylose isomerase domain protein TIM barrel
B4918_12050	COG0346	lactoylglutathione lyase activity
B4918_12060	COG0604	alcohol dehydrogenase
B4918_12085	COG0426	domain, Protein
B4918_12085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4918_12095	COG0386	Belongs to the glutathione peroxidase family
B4918_12100	COG1305	Transglutaminase-like
B4918_12105	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B4918_12110	COG0714	Associated with various cellular activities
B4918_12115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B4918_12120	COG1140	nitrate reductase beta subunit
B4918_12125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B4918_12130	COG2181	nitrate reductase activity
B4918_12135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4918_12140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4918_12145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4918_12150	COG0303	'Molybdopterin
B4918_12155	COG0314	molybdopterin synthase activity
B4918_12165	COG2223	nitrite transmembrane transporter activity
B4918_12185	COG1648	precorrin-2 dehydrogenase activity
B4918_12190	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B4918_12195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4918_12195	COG1587	Uroporphyrinogen-III synthase
B4918_12200	COG2146	nitrite reductase [NAD(P)H] activity
B4918_12205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4918_12210	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
B4918_12245	COG2359	stage V sporulation protein S
B4918_12265	COG2801	Transposase and inactivated derivatives
B4918_12275	COG0457	Tetratricopeptide repeat
B4918_12290	COG1418	mRNA catabolic process
B4918_12295	COG0488	(ABC) transporter
B4918_12310	COG0629	single-stranded DNA binding
B4918_12320	COG1413	lyase activity
B4918_12335	COG2521	methyltransferase
B4918_12335	COG2136	Putative SAM-dependent methyltransferase
B4918_12340	COG0018	arginyl-trna synthetase
B4918_12385	COG0017	Asparaginyl-tRNA synthetase
B4918_12390	COG0733	neurotransmitter:sodium symporter activity
B4918_12415	COG2610	gluconate transmembrane transporter activity
B4918_12425	COG1794	racemase activity, acting on amino acids and derivatives
B4918_12435	COG0456	acetyltransferase
B4918_12445	COG3655	Transcriptional regulator
B4918_12450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B4918_12475	COG0546	phosphoglycolate phosphatase activity
B4918_12505	COG0768	penicillin binding
B4918_12515	COG0204	Acyl-transferase
B4918_12520	COG1272	protein, Hemolysin III
B4918_12530	COG0805	protein transport
B4918_12540	COG1307	EDD domain protein, DegV family
B4918_12550	COG1999	signal sequence binding
B4918_12555	COG0071	Belongs to the small heat shock protein (HSP20) family
B4918_12560	COG0367	asparagine synthase
B4918_12575	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4918_12580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_12585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4918_12605	COG1335	isochorismatase
B4918_12610	COG1051	belongs to the nudix hydrolase family
B4918_12615	COG0668	transmembrane transport
B4918_12620	COG4585	Histidine kinase
B4918_12620	COG2203	Gaf domain
B4918_12625	COG2197	response regulator
B4918_12630	COG1737	Transcriptional regulator
B4918_12635	COG0384	phenazine biosynthesis protein PhzF
B4918_12640	COG1064	alcohol dehydrogenase
B4918_12655	COG1070	Carbohydrate kinase
B4918_12660	COG1070	Carbohydrate kinase
B4918_12670	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4918_12710	COG1174	glycine betaine transport
B4918_12745	COG1253	flavin adenine dinucleotide binding
B4918_12750	COG1012	belongs to the aldehyde dehydrogenase family
B4918_12755	COG5506	Protein of unknown function (DUF1694)
B4918_12775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4918_12780	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4918_12785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4918_12790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4918_12795	COG0456	acetyltransferase
B4918_12800	COG3829	transcription factor binding
B4918_12805	COG1509	lysine 2,3-aminomutase activity
B4918_12840	COG4991	sh3 domain protein
B4918_12840	COG3064	Membrane
B4918_12840	COG0515	serine threonine protein kinase
B4918_12850	COG0671	phosphoesterase, PA-phosphatase related
B4918_12855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4918_12860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4918_12940	COG0300	oxidoreductase activity
B4918_12960	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4918_12960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4918_12970	COG2814	Major facilitator Superfamily
B4918_12975	COG4841	protein insertion into membrane
B4918_12980	COG0372	Belongs to the citrate synthase family
B4918_12985	COG2079	MmgE PrpD family protein
B4918_12990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B4918_12995	COG1960	acyl-CoA dehydrogenase activity
B4918_13000	COG2084	Dehydrogenase
B4918_13010	COG1280	lysine exporter protein (LysE YggA)
B4918_13015	COG1024	Enoyl-CoA hydratase
B4918_13030	COG0420	3'-5' exonuclease activity
B4918_13035	COG0419	ATPase involved in DNA repair
B4918_13060	COG2223	nitrite transmembrane transporter activity
B4918_13070	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_13075	COG1169	isochorismate synthase
B4918_13080	COG1021	2,3-dihydroxybenzoate-AMP ligase
B4918_13085	COG1535	isochorismatase
B4918_13085	COG3433	isochorismatase activity
B4918_13090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4918_13095	COG3251	PFAM MbtH domain protein
B4918_13100	COG2814	Major facilitator Superfamily
B4918_13115	COG0776	regulation of translation
B4918_13125	COG2318	DinB family
B4918_13135	COG1115	amino acid carrier protein
B4918_13155	COG1187	pseudouridine synthase activity
B4918_13160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4918_13165	COG1136	(ABC) transporter
B4918_13210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4918_13225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_13260	COG1247	-acetyltransferase
B4918_13295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_13325	COG0583	DNA-binding transcription factor activity
B4918_13330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4918_13340	COG0583	DNA-binding transcription factor activity
B4918_13345	COG2258	MOSC domain
B4918_13360	COG1132	(ABC) transporter
B4918_13365	COG1132	(ABC) transporter
B4918_13395	COG1396	sequence-specific DNA binding
B4918_13425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4918_13430	COG1595	DNA-templated transcription, initiation
B4918_13455	COG1649	PFAM Uncharacterised BCR, COG1649
B4918_13480	COG2971	BadF BadG BcrA BcrD
B4918_13490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4918_13500	COG1846	Transcriptional regulator
B4918_13515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_13530	COG0500	methyltransferase
B4918_13530	COG3615	Tellurite resistance protein tehB
B4918_13545	COG3961	Belongs to the TPP enzyme family
B4918_13590	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4918_13615	COG2002	toxin-antitoxin pair type II binding
B4918_13625	COG0730	response to heat
B4918_13635	COG1686	Belongs to the peptidase S11 family
B4918_13650	COG2814	Major facilitator Superfamily
B4918_13680	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_13735	COG0741	lytic transglycosylase activity
B4918_13745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_13755	COG0456	acetyltransferase
B4918_13765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4918_13770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4918_13775	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4918_13790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4918_13800	COG2234	aminopeptidase activity
B4918_13805	COG2814	Major facilitator Superfamily
B4918_13855	COG1396	sequence-specific DNA binding
B4918_13870	COG0726	polysaccharide deacetylase
B4918_13915	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_13930	COG0768	penicillin binding
B4918_13935	COG1595	DNA-templated transcription, initiation
B4918_13960	COG1408	metallophosphoesterase
B4918_13970	COG1131	(ABC) transporter
B4918_13980	COG1309	transcriptional regulator
B4918_13995	COG1960	acyl-CoA dehydrogenase activity
B4918_14000	COG0439	Biotin carboxylase
B4918_14005	COG0511	ligase activity, forming carbon-carbon bonds
B4918_14010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4918_14015	COG1024	Enoyl-CoA hydratase
B4918_14020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4918_14025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4918_14035	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_14060	COG1686	Belongs to the peptidase S11 family
B4918_14090	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4918_14105	COG3227	Zinc metalloprotease (Elastase)
B4918_14110	COG2207	Transcriptional regulator
B4918_14140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4918_14150	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_14155	COG1733	regulation of RNA biosynthetic process
B4918_14200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_14225	COG2323	membrane
B4918_14235	COG0693	protein deglycase activity
B4918_14245	COG3386	PFAM SMP-30 Gluconolaconase
B4918_14255	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B4918_14260	COG3773	Cell wall hydrolase
B4918_14270	COG0745	RESPONSE REGULATOR receiver
B4918_14275	COG2205	protein histidine kinase activity
B4918_14280	COG0583	DNA-binding transcription factor activity
B4918_14285	COG0667	Aldo Keto reductase
B4918_14305	COG1136	(ABC) transporter
B4918_14310	COG0577	efflux transmembrane transporter activity
B4918_14335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_14345	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4918_14400	COG2124	cytochrome p450
B4918_14440	COG0561	phosphatase activity
B4918_14445	COG5002	protein histidine kinase activity
B4918_14460	COG1819	glycosyl
B4918_14465	COG1794	racemase activity, acting on amino acids and derivatives
B4918_14505	COG2076	Multidrug Resistance protein
B4918_14510	COG2076	Multidrug Resistance protein
B4918_14515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4918_14515	COG0723	plastoquinol--plastocyanin reductase activity
B4918_14520	COG2814	Major facilitator Superfamily
B4918_14540	COG5002	protein histidine kinase activity
B4918_14560	COG0415	Belongs to the DNA photolyase family
B4918_14570	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4918_14605	COG1522	sequence-specific DNA binding
B4918_14610	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B4918_14630	COG2155	Conserved Protein
B4918_14635	COG0697	spore germination
B4918_14690	COG1957	nucleoside hydrolase
B4918_14725	COG1113	amino acid transport
B4918_14730	COG1280	lysine exporter protein (LysE YggA)
B4918_14735	COG3403	YqcI/YcgG family
B4918_14745	COG5577	PFAM Coat F domain
B4918_14760	COG1533	DNA photolyase activity
B4918_14800	COG2205	protein histidine kinase activity
B4918_14865	COG2169	Transcriptional regulator
B4918_14895	COG0604	alcohol dehydrogenase
B4918_14900	COG0671	phosphoesterase, PA-phosphatase related
B4918_14995	COG0584	glycerophosphoryl diester phosphodiesterase
B4918_15015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_15020	COG0697	spore germination
B4918_15045	COG0494	nUDIX hydrolase
B4918_15080	COG0592	DNA-directed DNA polymerase activity
B4918_15085	COG1051	belongs to the nudix hydrolase family
B4918_15110	COG3878	Protein conserved in bacteria
B4918_15140	COG4667	esterase of the alpha-beta hydrolase superfamily
B4918_15180	COG0322	excinuclease ABC activity
B4918_15215	COG1819	glycosyl
B4918_15220	COG1819	glycosyl
B4918_15235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4918_15265	COG0745	RESPONSE REGULATOR receiver
B4918_15270	COG5002	protein histidine kinase activity
B4918_15285	COG1136	(ABC) transporter
B4918_15290	COG0577	efflux transmembrane transporter activity
B4918_15295	COG1073	alpha beta
B4918_15305	COG0076	glutamate decarboxylase activity
B4918_15320	COG1523	belongs to the glycosyl hydrolase 13 family
B4918_15325	COG3227	Zinc metalloprotease (Elastase)
B4918_15330	COG0737	Belongs to the 5'-nucleotidase family
B4918_15350	COG0346	lactoylglutathione lyase activity
B4918_15355	COG0201	protein transport
B4918_15360	COG0697	spore germination
B4918_15365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_15400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_15415	COG2959	enzyme of heme biosynthesis
B4918_15420	COG3773	Cell wall hydrolase
B4918_15420	COG3409	Peptidoglycan-binding domain 1 protein
B4918_15455	COG1309	transcriptional regulator
B4918_15475	COG3284	Transcriptional regulator
B4918_15495	COG1349	DNA-binding transcription factor activity
B4918_15510	COG1959	2 iron, 2 sulfur cluster binding
B4918_15525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4918_15530	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4918_15535	COG0022	dehydrogenase e1 component
B4918_15540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4918_15550	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_15580	COG4176	ABC-type proline glycine betaine transport system permease component
B4918_15585	COG4175	Glycine betaine
B4918_15585	COG0517	IMP dehydrogenase activity
B4918_15615	COG2153	protein acetylation
B4918_15635	COG3397	chitin binding
B4918_15640	COG1819	glycosyl
B4918_15650	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4918_15660	COG2205	protein histidine kinase activity
B4918_15665	COG2226	methyltransferase
B4918_15670	COG2315	Protein conserved in bacteria
B4918_15720	COG0456	acetyltransferase
B4918_15725	COG3973	AAA domain
B4918_15740	COG0514	ATP-dependent DNA helicase (RecQ)
B4918_15775	COG4637	Psort location Cytoplasmic, score
B4918_15795	COG3397	chitin binding
B4918_15810	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4918_15815	COG1115	amino acid carrier protein
B4918_15820	COG1012	belongs to the aldehyde dehydrogenase family
B4918_15825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4918_15835	COG3938	Belongs to the proline racemase family
B4918_15840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4918_15880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4918_15885	COG1078	dGTPase activity
B4918_15890	COG0586	Pfam SNARE associated Golgi protein
B4918_15900	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4918_15905	COG4166	transmembrane transport
B4918_15915	COG4948	Mandelate Racemase Muconate Lactonizing
B4918_15930	COG0667	Aldo Keto reductase
B4918_15975	COG3850	Histidine kinase
B4918_15975	COG5002	protein histidine kinase activity
B4918_15980	COG0745	RESPONSE REGULATOR receiver
B4918_16005	COG1164	Oligoendopeptidase f
B4918_16010	COG1307	EDD domain protein, DegV family
B4918_16060	COG1664	Polymer-forming cytoskeletal
B4918_16065	COG0789	Transcriptional regulator
B4918_16070	COG4533	DNA binding
B4918_16125	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_16140	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_16215	COG1802	Transcriptional regulator
B4918_16215	COG4626	Terminase
B4918_16300	COG1191	sigma factor activity
B4918_16325	COG3645	SOS response
B4918_16325	COG3646	Phage regulatory protein
B4918_16340	COG1396	sequence-specific DNA binding
B4918_16375	COG2261	transglycosylase associated protein
B4918_16390	COG2226	methyltransferase
B4918_16430	COG0436	Aminotransferase
B4918_16435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4918_16445	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4918_16460	COG1131	(ABC) transporter
B4918_16510	COG0628	permease
B4918_16530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4918_16535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4918_16565	COG2746	aminoglycoside 3-N-acetyltransferase activity
B4918_16575	COG0697	spore germination
B4918_16580	COG2318	DinB family
B4918_16600	COG4912	Dna alkylation repair
B4918_16605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4918_16610	COG0346	lactoylglutathione lyase activity
B4918_16615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_16630	COG0726	polysaccharide deacetylase
B4918_16650	COG0861	Integral membrane protein TerC family
B4918_16655	COG1368	sulfuric ester hydrolase activity
B4918_16660	COG0488	(ABC) transporter
B4918_16665	COG2409	Drug exporters of the RND superfamily
B4918_16665	COG1033	growth of symbiont in host cell
B4918_16670	COG1309	transcriptional regulator
B4918_16685	COG0287	Prephenate dehydrogenase
B4918_16705	COG1605	Chorismate mutase
B4918_16705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4918_16740	COG1388	LysM domain
B4918_16740	COG3584	3D domain protein
B4918_16770	COG1879	ABC-type sugar transport system periplasmic component
B4918_16780	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4918_16790	COG2390	Transcriptional regulator
B4918_16795	COG1070	Carbohydrate kinase
B4918_16825	COG2329	Antibiotic biosynthesis monooxygenase
B4918_16840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4918_16860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4918_16865	COG4187	Peptidase family M20/M25/M40
B4918_16880	COG0833	amino acid
B4918_16890	COG1690	Belongs to the RtcB family
B4918_16895	COG3239	Fatty acid desaturase
B4918_16905	COG2720	vancomycin resistance protein
B4918_16910	COG1785	Belongs to the alkaline phosphatase family
B4918_16920	COG3655	Transcriptional regulator
B4918_16940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_16945	COG0346	lactoylglutathione lyase activity
B4918_16970	COG0714	Associated with various cellular activities
B4918_16995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4918_17000	COG0753	catalase activity
B4918_17065	COG0778	Nitroreductase
B4918_17070	COG1846	Transcriptional regulator
B4918_17095	COG3831	ATPase activity
B4918_17095	COG4884	unkown
B4918_17105	COG1136	(ABC) transporter
B4918_17125	COG2207	Transcriptional regulator
B4918_17130	COG0456	acetyltransferase
B4918_17140	COG2816	NAD+ diphosphatase activity
B4918_17145	COG0697	spore germination
B4918_17150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_17190	COG0730	response to heat
B4918_17200	COG0833	amino acid
B4918_17265	COG5002	protein histidine kinase activity
B4918_17325	COG1984	allophanate hydrolase subunit 2
B4918_17330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4918_17335	COG1414	Transcriptional regulator
B4918_17350	COG0640	Transcriptional regulator
B4918_17360	COG1960	acyl-CoA dehydrogenase activity
B4918_17415	COG3848	Pyruvate phosphate dikinase
B4918_17415	COG0574	Belongs to the PEP-utilizing enzyme family
B4918_17425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_17445	COG1063	alcohol dehydrogenase
B4918_17455	COG1027	Aspartate ammonia-lyase
B4918_17460	COG0252	asparaginase activity
B4918_17465	COG1396	sequence-specific DNA binding
B4918_17495	COG5002	protein histidine kinase activity
B4918_17520	COG2207	Transcriptional regulator
B4918_17540	COG0322	excinuclease ABC activity
B4918_17545	COG0531	amino acid
B4918_17550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4918_17560	COG0531	amino acid
B4918_17565	COG0697	spore germination
B4918_17575	COG0784	Response regulator, receiver
B4918_17580	COG4191	Histidine kinase
B4918_17590	COG1115	amino acid carrier protein
B4918_17600	COG2124	cytochrome p450
B4918_17615	COG0737	Belongs to the 5'-nucleotidase family
B4918_17620	COG2267	carboxylic ester hydrolase activity
B4918_17625	COG1335	isochorismatase
B4918_17645	COG0583	DNA-binding transcription factor activity
B4918_17655	COG0598	Magnesium transport protein CorA
B4918_17680	COG1073	alpha beta
B4918_17700	COG0415	Belongs to the DNA photolyase family
B4918_17705	COG0288	reversible hydration of carbon dioxide
B4918_17715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4918_17720	COG5609	conserved protein (DUF2294)
B4918_17735	COG0697	spore germination
B4918_17740	COG0726	polysaccharide deacetylase
B4918_17750	COG1575	Belongs to the MenA family. Type 1 subfamily
B4918_17755	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4918_17760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4918_17765	COG1121	(ABC) transporter
B4918_17785	COG0798	PFAM Bile acid sodium symporter
B4918_17790	COG0346	lactoylglutathione lyase activity
B4918_17795	COG0640	Transcriptional regulator
B4918_17810	COG0583	DNA-binding transcription factor activity
B4918_17840	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_17860	COG1476	TRANSCRIPTIONal
B4918_17870	COG0825	malonyl-CoA metabolic process
B4918_17885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4918_17885	COG3320	Male sterility
B4918_17895	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_17900	COG1522	sequence-specific DNA binding
B4918_17915	COG0346	lactoylglutathione lyase activity
B4918_17950	COG0745	RESPONSE REGULATOR receiver
B4918_17955	COG3850	Histidine kinase
B4918_17955	COG5002	protein histidine kinase activity
B4918_17995	COG0277	FAD linked oxidase domain protein
B4918_18010	COG1136	(ABC) transporter
B4918_18050	COG2814	Major facilitator Superfamily
B4918_18070	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B4918_18090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B4918_18110	COG0577	efflux transmembrane transporter activity
B4918_18120	COG5002	protein histidine kinase activity
B4918_18120	COG3850	Histidine kinase
B4918_18135	COG1846	Transcriptional regulator
B4918_18150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_18165	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4918_18185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4918_18205	COG0662	Cupin 2, conserved barrel domain protein
B4918_18215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_18215	COG2207	Transcriptional regulator
B4918_18240	COG3409	Peptidoglycan-binding domain 1 protein
B4918_18240	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_18255	COG2814	Major facilitator Superfamily
B4918_18450	COG1876	peptidase activity
B4918_18455	COG2843	Capsule synthesis protein
B4918_18465	COG0477	Major facilitator Superfamily
B4918_18480	COG1846	Transcriptional regulator
B4918_18485	COG2814	Major facilitator Superfamily
B4918_18500	COG2031	fatty acid transporter
B4918_18510	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4918_18565	COG1288	antiporter activity
B4918_18570	COG2356	endonuclease I
B4918_18580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4918_18585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4918_18605	COG1733	regulation of RNA biosynthetic process
B4918_18610	COG0778	Nitroreductase
B4918_18645	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_18655	COG1131	(ABC) transporter
B4918_18680	COG1011	Hydrolase
B4918_18715	COG1051	belongs to the nudix hydrolase family
B4918_18725	COG0346	lactoylglutathione lyase activity
B4918_18730	COG1940	carbohydrate kinase activity
B4918_18735	COG0738	Major facilitator superfamily
B4918_18740	COG0110	maltose O-acetyltransferase activity
B4918_18745	COG0180	Tryptophanyl-tRNA synthetase
B4918_18755	COG0628	permease
B4918_18800	COG0477	Major facilitator Superfamily
B4918_18830	COG1253	flavin adenine dinucleotide binding
B4918_18835	COG0789	Transcriptional regulator
B4918_18840	COG0697	spore germination
B4918_18855	COG1357	PFAM Pentapeptide repeats (8 copies)
B4918_18860	COG3813	Protein conserved in bacteria
B4918_18865	COG2706	6-phosphogluconolactonase activity
B4918_18870	COG1070	Carbohydrate kinase
B4918_18875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4918_18880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4918_18885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B4918_18890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4918_18915	COG0814	amino acid
B4918_18940	COG1393	Belongs to the ArsC family
B4918_18945	COG1733	regulation of RNA biosynthetic process
B4918_18950	COG2188	Transcriptional regulator
B4918_18955	COG0673	inositol 2-dehydrogenase activity
B4918_18975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_19005	COG0318	PFAM AMP-dependent synthetase and ligase
B4918_19010	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4918_19015	COG1733	regulation of RNA biosynthetic process
B4918_19020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4918_19035	COG0726	polysaccharide deacetylase
B4918_19045	COG1191	sigma factor activity
B4918_19090	COG1151	hydroxylamine reductase activity
B4918_19100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_19155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_19160	COG0604	alcohol dehydrogenase
B4918_19165	COG1113	amino acid transport
B4918_19170	COG2814	Major facilitator Superfamily
B4918_19205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4918_19210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4918_19225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_19230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_19235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_19240	COG3739	integral membrane protein
B4918_19270	COG0583	DNA-binding transcription factor activity
B4918_19290	COG1193	negative regulation of DNA recombination
B4918_19305	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4918_19310	COG1164	Oligoendopeptidase f
B4918_19315	COG2957	Belongs to the agmatine deiminase family
B4918_19345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4918_19355	COG2271	Major facilitator Superfamily
B4918_19370	COG0584	glycerophosphoryl diester phosphodiesterase
B4918_19380	COG0640	Transcriptional regulator
B4918_19385	COG0604	alcohol dehydrogenase
B4918_19400	COG0457	Tetratricopeptide repeat
B4918_19410	COG0385	Bile acid
B4918_19415	COG0277	FAD linked oxidase domain protein
B4918_19435	COG1252	NADH dehydrogenase
B4918_19450	COG4641	Protein conserved in bacteria
B4918_19460	COG2089	acid synthase
B4918_19475	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B4918_19480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4918_19485	COG1088	dTDP-glucose 4,6-dehydratase activity
B4918_19495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4918_19500	COG0463	Glycosyl transferase, family 2
B4918_19505	COG0463	Glycosyl transferase, family 2
B4918_19515	COG0823	Involved in the tonB-independent uptake of proteins
B4918_19520	COG3397	chitin binding
B4918_19530	COG0697	spore germination
B4918_19550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4918_19570	COG0457	Tetratricopeptide repeat
B4918_19630	COG1309	transcriptional regulator
B4918_19645	COG1876	peptidase activity
B4918_19670	COG3852	Histidine kinase
B4918_19680	COG1285	pathogenesis
B4918_19690	COG2514	catechol 2,3-dioxygenase activity
B4918_19695	COG2720	vancomycin resistance protein
B4918_19725	COG1278	Cold shock
B4918_19735	COG0716	FMN binding
B4918_19745	COG0494	nUDIX hydrolase
B4918_19765	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_19775	COG0165	Argininosuccinate lyase
B4918_19790	COG4145	pantothenate transmembrane transporter activity
B4918_19800	COG1012	belongs to the aldehyde dehydrogenase family
B4918_19805	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_19815	COG1657	PFAM Prenyltransferase squalene oxidase
B4918_19820	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4918_19825	COG2962	Rard protein
B4918_19830	COG3326	Membrane
B4918_19845	COG0489	protein tyrosine kinase activity
B4918_19855	COG0314	molybdopterin synthase activity
B4918_19860	COG0303	'Molybdopterin
B4918_19865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4918_19870	COG2116	formate transmembrane transporter activity
B4918_19885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B4918_19890	COG5609	conserved protein (DUF2294)
B4918_19895	COG2427	Protein of unknown function (DUF1641)
B4918_19900	COG3383	formate dehydrogenase (NAD+) activity
B4918_19910	COG0697	spore germination
B4918_19955	COG2226	methyltransferase
B4918_19960	COG4166	transmembrane transport
B4918_19975	COG4166	transmembrane transport
B4918_19980	COG1301	dicarboxylic acid transport
B4918_19985	COG1316	TRANSCRIPTIONal
B4918_19995	COG1595	DNA-templated transcription, initiation
B4918_20005	COG1131	(ABC) transporter
B4918_20025	COG0673	inositol 2-dehydrogenase activity
B4918_20030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4918_20035	COG0187	DNA topoisomerase II activity
B4918_20045	COG1832	CoA-binding protein
B4918_20050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4918_20055	COG0745	RESPONSE REGULATOR receiver
B4918_20075	COG4841	protein insertion into membrane
B4918_20080	COG0824	Thioesterase
B4918_20105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4918_20120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4918_20130	COG0726	polysaccharide deacetylase
B4918_20150	COG2211	Major facilitator Superfamily
B4918_20160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4918_20180	COG0318	PFAM AMP-dependent synthetase and ligase
B4918_20185	COG1268	BioY protein
B4918_20190	COG0318	PFAM AMP-dependent synthetase and ligase
B4918_20195	COG1396	sequence-specific DNA binding
B4918_20235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_20250	COG5002	protein histidine kinase activity
B4918_20255	COG0400	carboxylic ester hydrolase activity
B4918_20260	COG0346	lactoylglutathione lyase activity
B4918_20265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4918_20275	COG0069	glutamate synthase activity
B4918_20280	COG1902	pentaerythritol trinitrate reductase activity
B4918_20285	COG1329	Transcriptional regulator
B4918_20290	COG0010	Belongs to the arginase family
B4918_20345	COG4846	Membrane protein involved in cytochrome C biogenesis
B4918_20350	COG0785	Cytochrome C biogenesis protein
B4918_20375	COG1131	(ABC) transporter
B4918_20395	COG0583	DNA-binding transcription factor activity
B4918_20420	COG0730	response to heat
B4918_20450	COG1132	(ABC) transporter
B4918_20455	COG1132	(ABC) transporter
B4918_20490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4918_20495	COG0737	Belongs to the 5'-nucleotidase family
B4918_20505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4918_20525	COG1695	Transcriptional regulator
B4918_20530	COG0174	glutamine synthetase
B4918_20535	COG0789	Transcriptional regulator
B4918_20540	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4918_20545	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4918_20550	COG2860	membrane
B4918_20555	COG0464	growth
B4918_20585	COG3584	3D domain protein
B4918_20585	COG1388	LysM domain
B4918_20595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4918_20595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4918_20595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4918_20600	COG1105	Belongs to the carbohydrate kinase PfkB family
B4918_20605	COG1349	DNA-binding transcription factor activity
B4918_20610	COG1979	alcohol dehydrogenase
B4918_20615	COG2322	membrane
B4918_20630	COG1113	amino acid transport
B4918_20655	COG1408	metallophosphoesterase
B4918_20660	COG2116	formate transmembrane transporter activity
B4918_20675	COG2217	Heavy metal translocating P-type atpase
B4918_20680	COG2608	mercury ion transmembrane transporter activity
B4918_20685	COG1937	Protein conserved in bacteria
B4918_20705	COG2819	hydrolase of the alpha beta superfamily
B4918_20710	COG1120	ATPase activity
B4918_20715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_20720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_20725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_20735	COG0708	Exodeoxyribonuclease III
B4918_20740	COG2169	Transcriptional regulator
B4918_20745	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4918_20750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4918_20760	COG2364	Membrane
B4918_20775	COG2267	carboxylic ester hydrolase activity
B4918_20780	COG5001	Diguanylate cyclase
B4918_20780	COG3300	MHYT domain
B4918_20820	COG1346	cytolysis
B4918_20830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4918_20845	COG0840	transmembrane signaling receptor activity
B4918_20850	COG0823	Involved in the tonB-independent uptake of proteins
B4918_20855	COG1404	Belongs to the peptidase S8 family
B4918_20860	COG3773	Cell wall hydrolase
B4918_20875	COG1368	sulfuric ester hydrolase activity
B4918_20880	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4918_20905	COG4550	Control of competence regulator ComK, YlbF/YmcA
B4918_20915	COG1013	pyruvate-flavodoxin oxidoreductase activity
B4918_20920	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B4918_20920	COG0674	pyruvate-flavodoxin oxidoreductase activity
B4918_20930	COG2359	stage V sporulation protein S
B4918_20935	COG1692	metallophosphoesterase
B4918_20960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4918_20965	COG1426	Protein conserved in bacteria
B4918_20980	COG0300	oxidoreductase activity
B4918_20985	COG0612	Peptidase, M16
B4918_20990	COG0612	Peptidase, M16
B4918_21015	COG2188	Transcriptional regulator
B4918_21035	COG0740	serine-type endopeptidase activity
B4918_21040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4918_21050	COG0527	aspartate kinase activity
B4918_21055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4918_21060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4918_21065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4918_21070	COG1873	PFAM PRC-barrel domain
B4918_21075	COG0612	Peptidase, M16
B4918_21080	COG0726	polysaccharide deacetylase
B4918_21095	COG0196	riboflavin kinase activity
B4918_21110	COG1550	Protein conserved in bacteria
B4918_21120	COG1358	cellular component organization or biogenesis
B4918_21125	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4918_21130	COG0195	Participates in both transcription termination and antitermination
B4918_21150	COG0750	zinc metalloprotease
B4918_21160	COG4589	Belongs to the CDS family
B4918_21205	COG4974	Belongs to the 'phage' integrase family
B4918_21215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4918_21220	COG0758	DNA mediated transformation
B4918_21225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4918_21265	COG1837	Belongs to the UPF0109 family
B4918_21275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4918_21285	COG0552	protein localization to endoplasmic reticulum
B4918_21290	COG1196	nuclear chromosome segregation
B4918_21305	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_21310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4918_21325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4918_21330	COG1461	Dihydroxyacetone kinase
B4918_21335	COG1302	Protein conserved in bacteria
B4918_21350	COG1564	THIamine pyrophosphokinase
B4918_21355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4918_21365	COG0515	serine threonine protein kinase
B4918_21365	COG2815	serine threonine protein kinase
B4918_21370	COG0631	protein serine/threonine phosphatase activity
B4918_21380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4918_21380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4918_21395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4918_21400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4918_21420	COG1561	YicC-like family, N-terminal region
B4918_21425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4918_21460	COG3069	C4-dicarboxylate transmembrane transporter activity
B4918_21520	COG0564	pseudouridine synthase activity
B4918_21540	COG3599	regulation of cell shape
B4918_21545	COG2302	S4 RNA-binding domain
B4918_21550	COG0762	integral membrane protein
B4918_21560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4918_21570	COG1873	PFAM PRC-barrel domain
B4918_21575	COG1191	sigma factor activity
B4918_21580	COG1191	sigma factor activity
B4918_21590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B4918_21595	COG0849	cell division
B4918_21610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4918_21615	COG0772	Belongs to the SEDS family
B4918_21635	COG0768	penicillin binding
B4918_21660	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4918_21680	COG1399	metal-binding, possibly nucleic acid-binding protein
B4918_21690	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4918_21695	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4918_21700	COG3314	Sporulation integral membrane protein YlbJ
B4918_21710	COG0742	ribosomal rna small subunit methyltransferase
B4918_21725	COG3679	Belongs to the UPF0342 family
B4918_21730	COG0406	alpha-ribazole phosphatase activity
B4918_21745	COG2340	Cysteine-rich secretory protein family
B4918_21760	COG3336	cytochrome c oxidase
B4918_21795	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B4918_21805	COG0772	Belongs to the SEDS family
B4918_21815	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4918_21820	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4918_21830	COG4896	Protein conserved in bacteria
B4918_21855	COG0483	inositol monophosphate 1-phosphatase activity
B4918_21875	COG1982	Orn Lys Arg decarboxylase major
B4918_21925	COG0022	dehydrogenase e1 component
B4918_21930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4918_21945	COG0561	phosphatase activity
B4918_21960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4918_21965	COG0569	domain protein
B4918_21985	COG0583	DNA-binding transcription factor activity
B4918_21990	COG0517	IMP dehydrogenase activity
B4918_22000	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B4918_22010	COG4703	Protein of unknown function (DUF1797)
B4918_22025	COG2200	EAL domain
B4918_22030	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_22035	COG1408	metallophosphoesterase
B4918_22080	COG2814	Major facilitator Superfamily
B4918_22100	COG3209	COG3209 Rhs family protein
B4918_22120	COG2205	protein histidine kinase activity
B4918_22130	COG0436	Aminotransferase
B4918_22135	COG1609	Transcriptional regulator
B4918_22140	COG3833	ABC-type maltose transport systems, permease component
B4918_22145	COG1175	transmembrane transport
B4918_22150	COG2182	Extracellular solute-binding protein
B4918_22160	COG0366	Alpha amylase catalytic
B4918_22165	COG3842	ATPase activity
B4918_22205	COG0183	Belongs to the thiolase family
B4918_22240	COG1695	Transcriptional regulator
B4918_22245	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_22265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4918_22270	COG0436	Aminotransferase
B4918_22305	COG2084	Dehydrogenase
B4918_22315	COG2199	diguanylate cyclase activity
B4918_22315	COG2203	Gaf domain
B4918_22320	COG0778	Nitroreductase
B4918_22345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4918_22345	COG1263	PTS System
B4918_22345	COG2190	(PTS) system
B4918_22350	COG3711	transcriptional antiterminator
B4918_22370	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4918_22400	COG1547	Domain of unknown function (DUF309)
B4918_22405	COG0456	acetyltransferase
B4918_22410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4918_22415	COG4086	secreted protein
B4918_22420	COG0561	phosphatase activity
B4918_22425	COG0697	spore germination
B4918_22440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4918_22465	COG0733	neurotransmitter:sodium symporter activity
B4918_22485	COG1686	Belongs to the peptidase S11 family
B4918_22495	COG1725	Transcriptional regulator
B4918_22500	COG1131	(ABC) transporter
B4918_22520	COG1846	Transcriptional regulator
B4918_22535	COG0598	Magnesium transport protein CorA
B4918_22560	COG4974	Belongs to the 'phage' integrase family
B4918_22570	COG0735	belongs to the Fur family
B4918_22575	COG1300	Membrane
B4918_22595	COG0667	Aldo Keto reductase
B4918_22600	COG0656	L-ascorbic acid biosynthetic process
B4918_22605	COG0456	acetyltransferase
B4918_22605	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B4918_22615	COG1525	nuclease
B4918_22615	COG0737	Belongs to the 5'-nucleotidase family
B4918_22615	COG4085	toxin activity
B4918_22625	COG0596	Alpha beta hydrolase
B4918_22630	COG2056	Na+-H+ antiporter family
B4918_22635	COG1609	Transcriptional regulator
B4918_22640	COG0456	acetyltransferase
B4918_22645	COG1073	alpha beta
B4918_22660	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4918_22660	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4918_22665	COG0307	riboflavin synthase, alpha
B4918_22695	COG1073	alpha beta
B4918_22695	COG2226	methyltransferase
B4918_22710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4918_22730	COG0737	Belongs to the 5'-nucleotidase family
B4918_22740	COG1522	sequence-specific DNA binding
B4918_22785	COG0300	oxidoreductase activity
B4918_22790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_22795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4918_22800	COG1760	l-serine dehydratase
B4918_22805	COG1760	l-serine dehydratase
B4918_22835	COG1285	pathogenesis
B4918_22845	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4918_22850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_22865	COG1376	ErfK ybiS ycfS ynhG family protein
B4918_22870	COG4129	membrane
B4918_22875	COG1126	abc transporter atp-binding protein
B4918_22880	COG0765	amino acid transport
B4918_22885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4918_22905	COG2323	membrane
B4918_22910	COG0772	Belongs to the SEDS family
B4918_22920	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4918_22925	COG0022	dehydrogenase e1 component
B4918_22930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4918_22935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4918_22945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4918_22950	COG0280	phosphate acetyltransferase
B4918_22960	COG3290	protein histidine kinase activity
B4918_22960	COG3829	transcription factor binding
B4918_22970	COG0584	glycerophosphoryl diester phosphodiesterase
B4918_22975	COG3093	addiction module antidote protein HigA
B4918_22995	COG0750	zinc metalloprotease
B4918_23000	COG0497	DNA recombination
B4918_23010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B4918_23020	COG0142	geranyltranstransferase activity
B4918_23045	COG1302	Protein conserved in bacteria
B4918_23050	COG0439	Biotin carboxylase
B4918_23055	COG0511	ligase activity, forming carbon-carbon bonds
B4918_23100	COG3854	ATPases associated with a variety of cellular activities
B4918_23125	COG0006	proline dipeptidase activity
B4918_23140	COG3872	metal-dependent enzyme
B4918_23150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4918_23185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4918_23195	COG1609	Transcriptional regulator
B4918_23205	COG2076	Multidrug Resistance protein
B4918_23210	COG2076	Multidrug Resistance protein
B4918_23260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4918_23330	COG1459	type II secretion system
B4918_23335	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4918_23390	COG0646	methionine synthase
B4918_23390	COG1410	methionine synthase
B4918_23395	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4918_23395	COG0646	methionine synthase
B4918_23400	COG0626	cystathionine gamma-synthase activity
B4918_23405	COG0626	cystathionine gamma-synthase activity
B4918_23425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_23435	COG1940	carbohydrate kinase activity
B4918_23440	COG4483	Protein conserved in bacteria
B4918_23445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4918_23455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4918_23460	COG0704	Plays a role in the regulation of phosphate uptake
B4918_23470	COG0573	inorganic phosphate transmembrane transporter activity
B4918_23475	COG0573	inorganic phosphate transmembrane transporter activity
B4918_23490	COG0477	Major facilitator Superfamily
B4918_23495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4918_23505	COG5521	maltodextrose utilization protein MalA
B4918_23520	COG0735	belongs to the Fur family
B4918_23525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4918_23530	COG1121	(ABC) transporter
B4918_23535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_23565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4918_23570	COG2384	SAM-dependent methyltransferase
B4918_23580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4918_23585	COG0358	DNA primase activity
B4918_23595	COG1671	Belongs to the UPF0178 family
B4918_23605	COG0517	IMP dehydrogenase activity
B4918_23620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4918_23625	COG0295	cytidine deaminase activity
B4918_23630	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4918_23640	COG1480	7TM receptor with intracellular HD hydrolase
B4918_23645	COG1702	phosphate starvation-inducible protein PhoH
B4918_23665	COG1610	YqeY-like protein
B4918_23675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4918_23680	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4918_23710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4918_23715	COG1733	regulation of RNA biosynthetic process
B4918_23740	COG1466	dna polymerase III delta subunit
B4918_23750	COG2333	competence protein COMEC
B4918_23750	COG0658	competence protein
B4918_23755	COG2131	deaminase
B4918_23760	COG1555	photosystem II stabilization
B4918_23760	COG1596	polysaccharide export
B4918_23765	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4918_23775	COG2226	methyltransferase
B4918_23780	COG0799	negative regulation of ribosome biogenesis
B4918_23785	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4918_23795	COG1534	Rna-binding protein
B4918_23805	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4918_23810	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4918_23825	COG1191	sigma factor activity
B4918_23835	COG1595	DNA-templated transcription, initiation
B4918_23845	COG0778	Nitroreductase
B4918_23850	COG2357	RelA SpoT domain protein
B4918_23860	COG1785	Belongs to the alkaline phosphatase family
B4918_23870	COG2267	carboxylic ester hydrolase activity
B4918_23905	COG1404	Belongs to the peptidase S8 family
B4918_23910	COG3186	Phenylalanine-4-hydroxylase
B4918_23920	COG2514	catechol 2,3-dioxygenase activity
B4918_23925	COG2259	Doxx family
B4918_23965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_23980	COG1454	alcohol dehydrogenase
B4918_23980	COG1012	belongs to the aldehyde dehydrogenase family
B4918_23985	COG0626	cystathionine gamma-synthase activity
B4918_23990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4918_24015	COG0768	penicillin binding
B4918_24050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4918_24080	COG0628	permease
B4918_24100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4918_24115	COG1104	cysteine desulfurase activity
B4918_24120	COG1959	2 iron, 2 sulfur cluster binding
B4918_24125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4918_24140	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4918_24175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4918_24185	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4918_24185	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4918_24190	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4918_24195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4918_24195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4918_24205	COG2244	polysaccharide biosynthetic process
B4918_24210	COG2323	membrane
B4918_24220	COG1862	Preprotein translocase
B4918_24250	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4918_24280	COG0157	Belongs to the NadC ModD family
B4918_24285	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4918_24290	COG1104	cysteine desulfurase activity
B4918_24295	COG1827	regulation of RNA biosynthetic process
B4918_24300	COG2258	MOSC domain
B4918_24310	COG0077	Prephenate dehydratase
B4918_24315	COG0577	efflux transmembrane transporter activity
B4918_24320	COG0577	efflux transmembrane transporter activity
B4918_24325	COG1136	(ABC) transporter
B4918_24330	COG5002	protein histidine kinase activity
B4918_24335	COG0745	RESPONSE REGULATOR receiver
B4918_24345	COG3290	protein histidine kinase activity
B4918_24355	COG2868	ribosomal protein
B4918_24365	COG1530	ribonuclease E activity
B4918_24370	COG1994	Peptidase M50
B4918_24375	COG0739	heme binding
B4918_24380	COG2894	cell division
B4918_24395	COG1792	Involved in formation and maintenance of cell shape
B4918_24400	COG1077	Cell shape determining protein MreB Mrl
B4918_24430	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_24650	COG0285	dihydrofolate synthase activity
B4918_24665	COG1388	LysM domain
B4918_24675	COG0113	porphobilinogen synthase activity
B4918_24680	COG1587	Uroporphyrinogen-III synthase
B4918_24690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4918_24700	COG1846	Transcriptional regulator
B4918_24705	COG1764	response to oxidative stress
B4918_24720	COG1067	ATP-dependent peptidase activity
B4918_24720	COG0470	DNA polymerase III
B4918_24805	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B4918_24825	COG0622	Phosphoesterase
B4918_24840	COG5401	PFAM Sporulation and spore germination
B4918_24860	COG1309	transcriptional regulator
B4918_24870	COG2197	response regulator
B4918_24875	COG2233	PERMEase
B4918_24880	COG0402	S-adenosylhomocysteine deaminase activity
B4918_24885	COG1983	PspC domain protein
B4918_24890	COG1396	sequence-specific DNA binding
B4918_24895	COG0697	spore germination
B4918_24915	COG1959	2 iron, 2 sulfur cluster binding
B4918_24920	COG1668	transmembrane transport
B4918_24925	COG4152	abc transporter atp-binding protein
B4918_24930	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
B4918_24935	COG1360	Flagellar Motor Protein
B4918_24940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4918_24945	COG1876	peptidase activity
B4918_24950	COG0824	Thioesterase
B4918_24955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4918_24960	COG1053	succinate dehydrogenase
B4918_24965	COG2009	succinate dehydrogenase
B4918_24970	COG1719	4-vinyl reductase, 4VR
B4918_24980	COG3118	belongs to the thioredoxin family
B4918_24985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4918_24990	COG2086	electron transfer activity
B4918_24995	COG1024	Enoyl-CoA hydratase
B4918_25000	COG1309	transcriptional regulator
B4918_25005	COG0318	PFAM AMP-dependent synthetase and ligase
B4918_25030	COG2318	DinB family
B4918_25050	COG1131	(ABC) transporter
B4918_25055	COG2205	protein histidine kinase activity
B4918_25060	COG0745	RESPONSE REGULATOR receiver
B4918_25070	COG4895	conserved protein (DUF2196)
B4918_25075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4918_25085	COG4509	Sortase family
B4918_25090	COG1120	ATPase activity
B4918_25105	COG5386	Cell surface protein
B4918_25115	COG5386	Cell surface protein
B4918_25120	COG1114	Component of the transport system for branched-chain amino acids
B4918_25125	COG1187	pseudouridine synthase activity
B4918_25140	COG1796	DNA polymerase
B4918_25140	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4918_25145	COG1286	toxin biosynthetic process
B4918_25170	COG0017	Asparaginyl-tRNA synthetase
B4918_25185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4918_25195	COG1418	mRNA catabolic process
B4918_25210	COG2814	Major facilitator Superfamily
B4918_25215	COG1566	PFAM secretion protein HlyD family protein
B4918_25220	COG1309	transcriptional regulator
B4918_25225	COG1363	Peptidase, m42
B4918_25250	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4918_25265	COG1484	DNA-dependent DNA replication
B4918_25270	COG3611	Membrane attachment protein
B4918_25280	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4918_25290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4918_25295	COG0237	dephospho-CoA kinase activity
B4918_25300	COG1971	Probably functions as a manganese efflux pump
B4918_25310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4918_25310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4918_25315	COG5002	protein histidine kinase activity
B4918_25320	COG0745	RESPONSE REGULATOR receiver
B4918_25350	COG0538	isocitrate dehydrogenase activity
B4918_25355	COG0372	Belongs to the citrate synthase family
B4918_25370	COG0628	permease
B4918_25375	COG3030	protein affecting phage T7 exclusion by the F plasmid
B4918_25400	COG1725	Transcriptional regulator
B4918_25405	COG0281	malic enzyme
B4918_25410	COG0587	DNA-directed DNA polymerase activity
B4918_25425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4918_25440	COG4109	DRTGG domain
B4918_25455	COG0006	proline dipeptidase activity
B4918_25485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_25490	COG0662	Cupin 2, conserved barrel domain protein
B4918_25505	COG1028	Short-chain dehydrogenase reductase Sdr
B4918_25510	COG0589	response to stress
B4918_25565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_25590	COG0827	DNA restriction-modification system
B4918_25595	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B4918_25600	COG3874	Sporulation protein YtfJ
B4918_25615	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B4918_25625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4918_25640	COG1104	cysteine desulfurase activity
B4918_25650	COG0583	DNA-binding transcription factor activity
B4918_25655	COG0697	spore germination
B4918_25660	COG1309	transcriptional regulator
B4918_25665	COG1956	GAF domain-containing protein
B4918_25670	COG0626	cystathionine gamma-synthase activity
B4918_25790	COG0110	maltose O-acetyltransferase activity
B4918_25795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4918_25800	COG0454	-acetyltransferase
B4918_25805	COG0517	IMP dehydrogenase activity
B4918_25810	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4918_25825	COG0745	RESPONSE REGULATOR receiver
B4918_25830	COG5002	protein histidine kinase activity
B4918_25835	COG0666	response to abiotic stimulus
B4918_25870	COG1609	Transcriptional regulator
B4918_25890	COG1605	Chorismate mutase
B4918_25890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4918_25895	COG4851	CamS sex pheromone cAM373 precursor
B4918_25900	COG3118	belongs to the thioredoxin family
B4918_25910	COG2309	aminopeptidase activity
B4918_25925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_25930	COG0697	spore germination
B4918_25935	COG0789	Transcriptional regulator
B4918_25950	COG1674	ftsk spoiiie
B4918_25965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4918_25975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4918_25980	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
B4918_25985	COG1363	Peptidase, m42
B4918_25995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_26010	COG0510	thiamine kinase activity
B4918_26015	COG1523	belongs to the glycosyl hydrolase 13 family
B4918_26030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4918_26035	COG1349	DNA-binding transcription factor activity
B4918_26040	COG1187	pseudouridine synthase activity
B4918_26045	COG2244	polysaccharide biosynthetic process
B4918_26050	COG2081	HI0933 family
B4918_26060	COG2814	Major facilitator Superfamily
B4918_26070	COG3832	glyoxalase III activity
B4918_26095	COG1329	Transcriptional regulator
B4918_26120	COG0314	molybdopterin synthase activity
B4918_26125	COG1763	Mo-molybdopterin cofactor biosynthetic process
B4918_26130	COG0303	'Molybdopterin
B4918_26140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4918_26145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4918_26170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4918_26180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B4918_26220	COG2814	Major facilitator Superfamily
B4918_26225	COG0475	glutathione-regulated potassium exporter activity
B4918_26230	COG0490	domain, Protein
B4918_26235	COG0582	viral genome integration into host DNA
B4918_26245	COG1136	(ABC) transporter
B4918_26265	COG1242	4 iron, 4 sulfur cluster binding
B4918_26270	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4918_26275	COG1794	racemase activity, acting on amino acids and derivatives
B4918_26295	COG2267	carboxylic ester hydrolase activity
B4918_26300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4918_26305	COG0671	phosphoesterase, PA-phosphatase related
B4918_26310	COG0438	transferase activity, transferring glycosyl groups
B4918_26410	COG5002	protein histidine kinase activity
B4918_26415	COG3852	Histidine kinase
B4918_26425	COG2267	carboxylic ester hydrolase activity
B4918_26430	COG1368	sulfuric ester hydrolase activity
B4918_26440	COG4895	conserved protein (DUF2196)
B4918_26455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4918_26460	COG1116	anion transmembrane transporter activity
B4918_26465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4918_26490	COG0494	nUDIX hydrolase
B4918_26525	COG2076	Multidrug Resistance protein
B4918_26530	COG2076	Multidrug Resistance protein
B4918_26535	COG0789	Transcriptional regulator
B4918_26550	COG0288	reversible hydration of carbon dioxide
B4918_26555	COG1271	oxidase subunit
B4918_26560	COG1294	oxidase, subunit
B4918_26580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_26605	COG1842	Phage shock protein A
B4918_26630	COG3859	Proton-coupled thiamine transporter YuaJ
B4918_26635	COG5002	protein histidine kinase activity
B4918_26640	COG0745	RESPONSE REGULATOR receiver
B4918_26670	COG1597	lipid kinase activity
B4918_26715	COG0586	Pfam SNARE associated Golgi protein
B4918_26725	COG0577	efflux transmembrane transporter activity
B4918_26730	COG1136	(ABC) transporter
B4918_26745	COG1131	(ABC) transporter
B4918_26750	COG5658	integral membrane protein
B4918_26755	COG0640	Transcriptional regulator
B4918_26765	COG0745	RESPONSE REGULATOR receiver
B4918_26770	COG2205	protein histidine kinase activity
B4918_26775	COG0577	efflux transmembrane transporter activity
B4918_26780	COG0577	efflux transmembrane transporter activity
B4918_26785	COG1136	(ABC) transporter
B4918_26790	COG0577	efflux transmembrane transporter activity
B4918_26825	COG3964	amidohydrolase
B4918_26850	COG4948	Mandelate Racemase Muconate Lactonizing
B4918_26860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B4918_26865	COG0596	Alpha beta hydrolase
B4918_26875	COG1169	isochorismate synthase
B4918_26880	COG1575	Belongs to the MenA family. Type 1 subfamily
B4918_26885	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4918_26890	COG1278	Cold shock
B4918_26920	COG0058	SHG alpha-glucan phosphorylase activity
B4918_26930	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4918_26960	COG0039	L-malate dehydrogenase activity
B4918_26965	COG1309	transcriptional regulator
B4918_27105	COG1285	pathogenesis
B4918_27110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4918_27130	COG2155	Conserved Protein
B4918_27135	COG1098	S1 RNA binding domain
B4918_27140	COG0436	Aminotransferase
B4918_27145	COG1522	sequence-specific DNA binding
B4918_27150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4918_27155	COG2267	carboxylic ester hydrolase activity
B4918_27165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4918_27185	COG5018	Exonuclease
B4918_27190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4918_27210	COG0423	glycine-tRNA ligase activity
B4918_27215	COG2050	protein possibly involved in aromatic compounds catabolism
B4918_27225	COG1268	BioY protein
B4918_27230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4918_27235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4918_27250	COG3584	3D domain protein
B4918_27265	COG1252	NADH dehydrogenase
B4918_27275	COG3708	Transcriptional regulator
B4918_27290	COG1683	Conserved Protein
B4918_27315	COG0316	Belongs to the HesB IscA family
B4918_27330	COG1252	NADH dehydrogenase
B4918_27340	COG2274	protein secretion by the type I secretion system
B4918_27345	COG0390	transport system, permease component
B4918_27350	COG2824	Alkylphosphonate utilization operon protein PhnA
B4918_27400	COG4837	Protein of unknown function (DUF1462)
B4918_27405	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4918_27415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4918_27420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4918_27440	COG1358	cellular component organization or biogenesis
B4918_27450	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4918_27455	COG0647	UMP catabolic process
B4918_27465	COG2445	Protein of unknown function DUF86
B4918_27470	COG1494	fructose-1,6-bisphosphatase
B4918_27490	COG4470	Protein conserved in bacteria
B4918_27500	COG0789	Transcriptional regulator
B4918_27505	COG4377	Putative membrane peptidase family (DUF2324)
B4918_27530	COG0739	heme binding
B4918_27540	COG3377	Domain of unknown function (DUF1805)
B4918_27545	COG0737	Belongs to the 5'-nucleotidase family
B4918_27575	COG0457	Tetratricopeptide repeat
B4918_27580	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_27580	COG3409	Peptidoglycan-binding domain 1 protein
B4918_27580	COG1388	LysM domain
B4918_27585	COG4824	toxin secretion phage lysis holin
B4918_27725	COG3331	DNA recombination
B4918_27805	COG3646	Phage regulatory protein
B4918_27820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4918_27825	COG0582	viral genome integration into host DNA
B4918_27830	COG0719	Fe-S assembly protein
B4918_27835	COG0822	iron-sulfur transferase activity
B4918_27840	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4918_27845	COG0719	Fe-S assembly protein
B4918_27850	COG0396	ATPase activity
B4918_27855	COG1464	Belongs to the NlpA lipoprotein family
B4918_27860	COG1464	Belongs to the NlpA lipoprotein family
B4918_27865	COG2011	ABC-type metal ion transport system permease component
B4918_27880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4918_27885	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4918_27895	COG1393	Belongs to the ArsC family
B4918_27915	COG0039	L-malate dehydrogenase activity
B4918_27935	COG1309	transcriptional regulator
B4918_27940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4918_27945	COG1960	acyl-CoA dehydrogenase activity
B4918_27950	COG0183	Belongs to the thiolase family
B4918_27955	COG1024	Enoyl-CoA hydratase
B4918_27955	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4918_27965	COG1686	Belongs to the peptidase S11 family
B4918_27980	COG0011	TIGRFAM Protein of
B4918_27985	COG0840	transmembrane signaling receptor activity
B4918_28000	COG2814	Major facilitator Superfamily
B4918_28005	COG0531	amino acid
B4918_28030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4918_28070	COG0586	Pfam SNARE associated Golgi protein
B4918_28080	COG1376	ErfK ybiS ycfS ynhG family protein
B4918_28085	COG0745	RESPONSE REGULATOR receiver
B4918_28120	COG0840	transmembrane signaling receptor activity
B4918_28125	COG2151	metal-sulfur cluster biosynthetic enzyme
B4918_28130	COG3227	Zinc metalloprotease (Elastase)
B4918_28150	COG0586	Pfam SNARE associated Golgi protein
B4918_28155	COG0475	glutathione-regulated potassium exporter activity
B4918_28160	COG0490	domain, Protein
B4918_28170	COG1115	amino acid carrier protein
B4918_28175	COG0783	Belongs to the Dps family
B4918_28195	COG1611	Belongs to the LOG family
B4918_28205	COG1528	Iron-storage protein
B4918_28215	COG2311	Membrane
B4918_28220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4918_28225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4918_28230	COG1115	amino acid carrier protein
B4918_28235	COG1115	amino acid carrier protein
B4918_28240	COG2910	NAD(P)H-binding
B4918_28260	COG0656	L-ascorbic acid biosynthetic process
B4918_28265	COG2814	Major facilitator Superfamily
B4918_28270	COG1733	regulation of RNA biosynthetic process
B4918_28280	COG1252	NADH dehydrogenase
B4918_28305	COG3290	protein histidine kinase activity
B4918_28305	COG0840	transmembrane signaling receptor activity
B4918_28340	COG0488	(ABC) transporter
B4918_28345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4918_28350	COG3223	Belongs to the PsiE family
B4918_28360	COG1335	isochorismatase
B4918_28375	COG1522	sequence-specific DNA binding
B4918_28380	COG0288	reversible hydration of carbon dioxide
B4918_28385	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B4918_28390	COG2233	PERMEase
B4918_28505	COG3104	oligopeptide transport
B4918_28545	COG0557	exoribonuclease II activity
B4918_28550	COG1647	Serine aminopeptidase, S33
B4918_28555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4918_28560	COG1346	cytolysis
B4918_28595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4918_28610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B4918_28620	COG3611	Membrane attachment protein
B4918_28630	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_28630	COG1388	LysM domain
B4918_28630	COG3409	Peptidoglycan-binding domain 1 protein
B4918_28635	COG4824	toxin secretion phage lysis holin
B4918_28775	COG3331	DNA recombination
B4918_28850	COG3646	Phage regulatory protein
B4918_28875	COG0582	viral genome integration into host DNA
B4918_28900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4918_28915	COG2323	membrane
B4918_28930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4918_28940	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4918_28950	COG1051	belongs to the nudix hydrolase family
B4918_28960	COG0492	ferredoxin-NADP+ reductase activity
B4918_28965	COG0457	Tetratricopeptide repeat
B4918_28970	COG0110	maltose O-acetyltransferase activity
B4918_28990	COG1950	PFAM Membrane protein of
B4918_29000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4918_29020	COG0789	Transcriptional regulator
B4918_29040	COG0583	DNA-binding transcription factor activity
B4918_29050	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4918_29055	COG0488	(ABC) transporter
B4918_29065	COG1132	(ABC) transporter
B4918_29070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4918_29075	COG3409	Peptidoglycan-binding domain 1 protein
B4918_29075	COG0793	Belongs to the peptidase S41A family
B4918_29080	COG2177	Part of the ABC transporter FtsEX involved in
B4918_29085	COG2884	Cell division ATP-binding protein ftsE
B4918_29100	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B4918_29115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4918_29120	COG1278	Cold shock
B4918_29125	COG1040	competence protein
B4918_29130	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4918_29135	COG0791	NLP P60 protein
B4918_29135	COG1388	LysM domain
B4918_29140	COG1733	regulation of RNA biosynthetic process
B4918_29150	COG1307	EDD domain protein, DegV family
B4918_29155	COG1739	Uncharacterized protein family UPF0029
B4918_29160	COG1316	TRANSCRIPTIONal
B4918_29165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4918_29170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4918_29175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4918_29185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B4918_29185	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B4918_29210	COG1486	melibiose metabolic process
B4918_29215	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4918_29220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4918_29230	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4918_29240	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4918_29255	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4918_29260	COG1301	dicarboxylic acid transport
B4918_29280	COG1511	domain protein
B4918_29285	COG0583	DNA-binding transcription factor activity
B4918_29300	COG1271	oxidase subunit
B4918_29305	COG1294	oxidase, subunit
B4918_29310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4918_29320	COG1620	l-lactate permease
B4918_29330	COG2389	metal-binding protein
B4918_29345	COG1368	sulfuric ester hydrolase activity
B4918_29365	COG0791	NLP P60 protein
B4918_29365	COG1388	LysM domain
B4918_29370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4918_29380	COG1215	transferase activity, transferring glycosyl groups
B4918_29390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4918_29400	COG1388	LysM domain
B4918_29400	COG3584	3D domain protein
B4918_29425	COG4715	Zinc finger, swim domain protein
B4918_29430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4918_29440	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_29470	COG1191	sigma factor activity
B4918_29480	COG0577	efflux transmembrane transporter activity
B4918_29485	COG1136	(ABC) transporter
B4918_29510	COG5002	protein histidine kinase activity
B4918_29515	COG0745	RESPONSE REGULATOR receiver
B4918_29520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4918_29525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4918_29545	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4918_29560	COG0438	transferase activity, transferring glycosyl groups
B4918_29565	COG1215	transferase activity, transferring glycosyl groups
B4918_29570	COG0438	transferase activity, transferring glycosyl groups
B4918_29585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4918_29590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4918_29595	COG1086	Polysaccharide biosynthesis protein
B4918_29600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4918_29605	COG4464	protein tyrosine phosphatase activity
B4918_29610	COG0489	protein tyrosine kinase activity
B4918_29615	COG3944	biosynthesis protein
B4918_29620	COG0489	protein tyrosine kinase activity
B4918_29635	COG1609	Transcriptional regulator
B4918_29645	COG0739	heme binding
B4918_29660	COG3279	Response regulator of the LytR AlgR family
B4918_29665	COG2385	sporulation resulting in formation of a cellular spore
B4918_29670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4918_29680	COG4836	Membrane
B4918_29685	COG1007	ATP synthesis coupled electron transport
B4918_29690	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4918_29695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4918_29705	COG0839	Belongs to the complex I subunit 6 family
B4918_29725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B4918_29740	COG3300	MHYT domain
B4918_29740	COG5001	Diguanylate cyclase
B4918_29795	COG0356	it plays a direct role in the translocation of protons across the membrane
B4918_29830	COG0698	ribose 5-phosphate isomerase
B4918_29845	COG2190	(PTS) system
B4918_29850	COG2259	Doxx family
B4918_29855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4918_29875	COG0009	L-threonylcarbamoyladenylate synthase
B4918_29895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4918_29915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4918_29920	COG1494	fructose-1,6-bisphosphatase
B4918_29950	COG4821	SIS domain
B4918_29970	COG1960	acyl-CoA dehydrogenase activity
B4918_29975	COG1960	acyl-CoA dehydrogenase activity
B4918_29980	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4918_29985	COG0183	Belongs to the thiolase family
B4918_29990	COG2181	nitrate reductase activity
B4918_29990	COG0247	lactate metabolic process
B4918_29995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4918_30005	COG5001	Diguanylate cyclase
B4918_30005	COG3300	MHYT domain
B4918_30025	COG2197	response regulator
B4918_30030	COG4585	Histidine kinase
B4918_30035	COG0842	Transport permease protein
B4918_30040	COG1131	(ABC) transporter
B4918_30045	COG0024	Methionine aminopeptidase
B4918_30055	COG2234	aminopeptidase activity
B4918_30080	COG4506	Protein conserved in bacteria
B4918_30085	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4918_30110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4918_30115	COG2814	Major facilitator Superfamily
B4918_30120	COG0789	Transcriptional regulator
B4918_30125	COG0584	glycerophosphoryl diester phosphodiesterase
B4918_30130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4918_30140	COG1994	Peptidase M50
B4918_30150	COG1078	dGTPase activity
B4918_30155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_30160	COG1120	ATPase activity
B4918_30165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_30170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4918_30190	COG0280	phosphate acetyltransferase
B4918_30205	COG3773	Cell wall hydrolase
B4918_30215	COG2363	Small membrane protein
B4918_30225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4918_30230	COG2233	PERMEase
B4918_30235	COG0561	phosphatase activity
B4918_30240	COG2814	Major facilitator Superfamily
B4918_30250	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4918_30255	COG1131	(ABC) transporter
B4918_30260	COG2755	lipolytic protein G-D-S-L family
B4918_30265	COG1609	Transcriptional regulator
B4918_30275	COG0460	homoserine dehydrogenase
B4918_30290	COG1011	Hydrolase
B4918_30295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4918_30305	COG2197	response regulator
B4918_30310	COG2203	Gaf domain
B4918_30310	COG4585	Histidine kinase
B4918_30315	COG0351	phosphomethylpyrimidine kinase
B4918_30320	COG3706	GGDEF domain
B4918_30325	COG2879	small protein
B4918_30330	COG1966	Carbon starvation protein
B4918_30335	COG3279	Response regulator of the LytR AlgR family
B4918_30340	COG0477	Major facilitator Superfamily
B4918_30355	COG0438	transferase activity, transferring glycosyl groups
B4918_30370	COG0840	transmembrane signaling receptor activity
B4918_30380	COG1607	acyl-coa hydrolase
B4918_30385	COG1216	Glycosyl transferase, family 2
B4918_30400	COG1216	Glycosyl transferase, family 2
B4918_30410	COG4485	Bacterial membrane protein, YfhO
B4918_30415	COG0463	Glycosyl transferase, family 2
B4918_30425	COG1309	transcriptional regulator
B4918_30430	COG0488	(ABC) transporter
B4918_30435	COG1309	transcriptional regulator
B4918_30440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4918_30445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4918_30445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4918_30450	COG0628	permease
B4918_30470	COG3275	phosphorelay sensor kinase activity
B4918_30475	COG2814	Major facilitator Superfamily
B4918_30480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4918_30485	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B4918_30520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4918_30525	COG1272	protein, Hemolysin III
B4918_30545	COG1164	Oligoendopeptidase f
B4918_30560	COG5002	protein histidine kinase activity
B4918_30575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4918_30580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4918_30585	COG4853	Protein conserved in bacteria
B4918_30595	COG5002	protein histidine kinase activity
B4918_30600	COG0745	RESPONSE REGULATOR receiver
B4918_30630	COG0305	Participates in initiation and elongation during chromosome replication
B4918_30640	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4918_30645	COG4241	membrane
B4918_30655	COG0629	single-stranded DNA binding
B4918_30665	COG0012	GTP binding
B4918_30670	COG4481	Protein conserved in bacteria
B4918_30675	COG0668	transmembrane transport
B4918_30685	COG1475	DNA binding
B4918_30690	COG1192	Involved in chromosome partitioning
B4918_30715	COG1847	R3H domain protein
B4918_30750	COG3331	DNA recombination
B4918_30775	COG0582	viral genome integration into host DNA
B4918_30790	COG5484	DNA packaging
B4918_30795	COG1783	phage Terminase large subunit
B4918_30810	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B4918_30815	COG4653	Phage capsid family
B4918_30925	COG3547	Transposase (IS116 IS110 IS902 family)
B4918_30940	COG0457	Tetratricopeptide repeat
B4918_31010	COG3620	sequence-specific DNA binding
B4918_31145	COG2002	toxin-antitoxin pair type II binding
B4918_31310	COG4653	Phage capsid family
B4918_31315	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B4918_31325	COG2369	cell adhesion
B4918_31330	COG5518	Phage portal protein
B4918_31345	COG4974	Belongs to the 'phage' integrase family
B4918_31350	COG5484	DNA packaging
B4918_31415	COG3344	reverse transcriptase
B4918_31475	COG3800	Transcriptional regulator
B4918_31475	COG1396	sequence-specific DNA binding
B4918_31575	COG0582	viral genome integration into host DNA
B4918_31655	COG0776	regulation of translation
B4918_31670	COG0457	Tetratricopeptide repeat
B4918_31685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4918_31700	COG0367	asparagine synthase
B4918_31705	COG1309	transcriptional regulator
B4918_31765	COG0457	Tetratricopeptide repeat
B4918_31845	COG1404	Belongs to the peptidase S8 family
B4918_31920	COG0592	DNA-directed DNA polymerase activity
B4918_31925	COG4712	double-strand break repair protein
B4918_31955	COG4282	regulation of fungal-type cell wall biogenesis
B4918_32175	COG3344	reverse transcriptase
B4918_32235	COG2311	Membrane
B4918_32295	COG3118	belongs to the thioredoxin family
B4918_32300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4918_32310	COG0457	Tetratricopeptide repeat
B4918_32335	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4918_32360	COG1051	belongs to the nudix hydrolase family
B4918_32375	COG3344	reverse transcriptase
B4918_32405	COG2002	toxin-antitoxin pair type II binding
B4918_32410	COG4166	transmembrane transport
B4918_32425	COG4974	Belongs to the 'phage' integrase family
B4918_32505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4918_32515	COG0840	transmembrane signaling receptor activity
B4918_32520	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4918_32530	COG0500	methyltransferase
B4918_32535	COG0747	negative chemotaxis
B4918_32540	COG0601	transmembrane transport
B4918_32550	COG0444	Belongs to the ABC transporter superfamily
B4918_32555	COG4608	Belongs to the ABC transporter superfamily
B4918_32575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4918_32610	COG1686	Belongs to the peptidase S11 family
B4918_32615	COG2814	Major facilitator Superfamily
B4918_32620	COG0697	spore germination
B4918_32625	COG0726	polysaccharide deacetylase
B4918_32650	COG1760	l-serine dehydratase
B4918_32655	COG1760	l-serine dehydratase
B4918_32660	COG0814	amino acid
B4918_32690	COG3290	protein histidine kinase activity
B4918_32690	COG0840	transmembrane signaling receptor activity
B4918_32710	COG1533	DNA photolyase activity
B4918_32740	COG0745	RESPONSE REGULATOR receiver
B4918_32745	COG2205	protein histidine kinase activity
B4918_32750	COG1136	(ABC) transporter
B4918_32755	COG0577	efflux transmembrane transporter activity
B4918_32770	COG0741	lytic transglycosylase activity
B4918_32780	COG0772	Belongs to the SEDS family
B4918_32790	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B4918_32795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4918_32800	COG0772	Belongs to the SEDS family
B4918_32810	COG2239	Acts as a magnesium transporter
B4918_32900	COG0586	Pfam SNARE associated Golgi protein
B4918_32915	COG2226	methyltransferase
B4918_32950	COG3344	reverse transcriptase
B4918_32995	COG0490	domain, Protein
B4918_33000	COG0475	glutathione-regulated potassium exporter activity
B4918_33005	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_33005	COG3409	Peptidoglycan-binding domain 1 protein
B4918_33050	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4918_33050	COG3409	Peptidoglycan-binding domain 1 protein
B4918_33080	COG4824	toxin secretion phage lysis holin
B4918_33110	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4918_33275	COG2801	Transposase and inactivated derivatives
B4918_33335	COG3344	reverse transcriptase