locus-tag class description CUC43_00020 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CUC43_00050 ENOG4105DSJ YicC domain protein CUC43_00060 ENOG4105F23 Fibronectin-binding protein CUC43_00070 ENOG4105DC7 peptidase M24 CUC43_00105 ENOG4105PAD Hydrolase CUC43_00135 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CUC43_00160 ENOG4105C34 Pseudouridine synthase CUC43_00185 ENOG4105DBK s4 domain protein CUC43_00190 ENOG41067XK integral membrane protein CUC43_00200 ENOG4105DFA alanine racemase domain protein CUC43_00205 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CUC43_00210 ENOG4105WR5 sporulation protein, YlmC YmxH family CUC43_00220 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CUC43_00230 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CUC43_00235 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CUC43_00240 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CUC43_00250 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CUC43_00255 ENOG4105CNI cell division protein FtsW CUC43_00270 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CUC43_00275 ENOG4105CJN penicillin-binding protein CUC43_00280 ENOG4105CJN penicillin-binding protein CUC43_00285 ENOG41068DC Essential cell division protein (By similarity) CUC43_00320 ENOG4105KNH Nucleic acid-binding protein CUC43_00445 ENOG4105CAR Terminase, large subunit CUC43_00505 ENOG41085W3 Transposase CUC43_00585 ENOG4105KRN Transcriptional regulator, abrb family CUC43_00595 ENOG4106CVF DNA replication protein CUC43_00625 ENOG4108IMY Transcriptional regulator CUC43_00660 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) CUC43_00670 ENOG41063PX domain protein CUC43_00680 ENOG4105H20 Sporulation integral membrane protein YlbJ CUC43_00690 ENOG4106H78 methyltransferase CUC43_00715 ENOG4107TB6 phosphoglycerate mutase CUC43_00730 ENOG4106UY4 Inherit from COG: Scp-like extracellular CUC43_00775 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CUC43_00785 ENOG4105CNI cell division protein FtsW CUC43_00800 ENOG4108IAB Phoh family CUC43_00820 ENOG4105QA2 CUC43_00825 ENOG4105CI3 gtp-binding protein typa CUC43_00835 ENOG4105ECY inositol monophosphatase CUC43_00855 ENOG4105CXN decarboxylase CUC43_00905 ENOG4105CPP Dehydrogenase, E1 component CUC43_00920 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CUC43_00925 ENOG4108X4Q Hydrolase CUC43_00940 ENOG4105CN5 Metallo-Beta-Lactamase CUC43_00945 ENOG4107ZYR domain protein CUC43_00980 ENOG4108XRC Protein of unknown function (DUF458) CUC43_00990 ENOG4107IN1 Protein of unknown function (DUF1797) CUC43_01005 ENOG4105EPM Diguanylate phosphodiesterase CUC43_01010 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CUC43_01030 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CUC43_01040 ENOG4105UIN CUC43_01105 ENOG4108HGU Histidine kinase CUC43_01115 ENOG4105CHM Aminotransferase CUC43_01120 ENOG4105FKQ transcriptional regulator CUC43_01125 ENOG4105EG2 ABC transporter, permease CUC43_01135 ENOG4107FKK extracellular solute-binding protein family 1 CUC43_01145 ENOG4105CG3 alpha amylase, catalytic region CUC43_01190 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CUC43_01195 ENOG4105CHU acetyl-coa acetyltransferase CUC43_01230 ENOG4105K7K Transcriptional regulator CUC43_01235 ENOG4105DTD Dehydrogenase CUC43_01255 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CUC43_01295 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CUC43_01305 ENOG4105BZU Histidine kinase CUC43_01325 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CUC43_01340 ENOG4105CID antiterminator CUC43_01350 ENOG4105FDP GntR family transcriptional regulator CUC43_01360 ENOG4105CE4 GlcNAc 6-P deacetylase CUC43_01405 ENOG4107ZE5 PPIases accelerate the folding of proteins CUC43_01410 ENOG4105PTM secreted protein CUC43_01415 ENOG4105J7I hydrolase CUC43_01425 ENOG4105G6R Stage v sporulation protein ae CUC43_01435 ENOG4105CZ3 stage V sporulation protein ad CUC43_01440 ENOG41090VF Stage v sporulation protein ac CUC43_01460 ENOG4105C8J )-transporter CUC43_01465 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CUC43_01475 ENOG41082AN stage II sporulation protein CUC43_01480 ENOG4105DZ1 carboxypeptidase CUC43_01490 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CUC43_01495 ENOG4105DVE abc transporter atp-binding protein CUC43_01530 ENOG4105D7N magnesium and cobalt transport protein CorA CUC43_01555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CUC43_01565 ENOG4105I3K Ferric uptake regulator, Fur family CUC43_01570 ENOG4105MZ9 stage II sporulation protein m CUC43_01590 ENOG4105CPC Aldo Keto reductase CUC43_01600 ENOG4105RHY Pfam:UPF0157 CUC43_01620 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CUC43_01630 ENOG4105ETE Transcriptional regulator (LacI family CUC43_01635 ENOG4108YM7 Gcn5-related n-acetyltransferase CUC43_01655 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CUC43_01660 ENOG4108R6K riboflavin synthase, subunit alpha CUC43_01680 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CUC43_01685 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CUC43_01690 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CUC43_01705 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CUC43_01720 ENOG4105DFD Na H antiporter CUC43_01725 ENOG4105CGH 5'-nucleotidase CUC43_01790 ENOG4108IXY short-chain dehydrogenase reductase CUC43_01795 ENOG41069FQ Metallo-beta-lactamase superfamily CUC43_01800 ENOG4105II7 pyrroline-5-carboxylate reductase CUC43_01805 ENOG4105EJQ L-serine dehydratase CUC43_01830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CUC43_01835 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CUC43_01845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CUC43_01850 ENOG4105D9U N-acetyltransferase CUC43_01865 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CUC43_01870 ENOG4108QEG Membrane CUC43_01875 ENOG4105CDA abc transporter atp-binding protein CUC43_01880 ENOG4105E5Q amino acid AbC transporter CUC43_01885 ENOG4108HW3 (ABC) transporter CUC43_01900 ENOG4105G7B Protein of unknown function (DUF2992) CUC43_01910 ENOG4108QY0 Membrane CUC43_01925 ENOG4105C7S Dehydrogenase CUC43_01930 ENOG4105CPP Dehydrogenase, E1 component CUC43_01945 ENOG4105CKM Branched-chain carboxylic acid kinase CUC43_01950 ENOG4107RDP Dehydrogenase CUC43_01965 ENOG4108JUB Transcriptional regulator CUC43_01975 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CUC43_01990 ENOG4107QQR Sporulation CUC43_02000 ENOG4105S1Z Stage IV sporulation protein B CUC43_02005 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CUC43_02015 ENOG4105DX0 Hemolysin A CUC43_02025 ENOG4105CTB Polyprenyl synthetase CUC43_02050 ENOG4108ZSR alkaline shock protein CUC43_02055 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CUC43_02080 ENOG410644B Stage III sporulation protein af CUC43_02090 ENOG4105KQ4 Stage iii sporulation protein ad CUC43_02095 ENOG4108CQH stage III sporulation protein AC CUC43_02100 ENOG4105KR5 Stage iii sporulation protein CUC43_02105 ENOG4105CD2 stage iii sporulation protein aa CUC43_02130 ENOG4105DC7 peptidase M24 CUC43_02145 ENOG4105CBJ Metal-dependent enzyme CUC43_02155 ENOG4107YBY Hydrolase CUC43_02190 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CUC43_02195 ENOG4105WZW rhodanese family CUC43_02220 ENOG41080TC multidrug resistance protein CUC43_02265 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CUC43_02280 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CUC43_02300 ENOG4105C0D helicase CUC43_02430 ENOG4105C3R Methionine synthase CUC43_02440 ENOG4105C28 cystathionine CUC43_02445 ENOG4105C28 cystathionine CUC43_02465 ENOG4105C5X domain protein CUC43_02475 ENOG4105DKQ ROK family CUC43_02485 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CUC43_02500 ENOG4108UTW Plays a role in the regulation of phosphate uptake CUC43_02505 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CUC43_02510 ENOG4105E2Z phosphate ABC transporter (Permease CUC43_02515 ENOG4105C8U phosphate abc transporter CUC43_02520 ENOG4105PWN phosphate abc transporter CUC43_02525 ENOG4107RF6 penicillin-binding protein CUC43_02535 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CUC43_02560 ENOG4105N80 Ferric uptake regulator, Fur family CUC43_02570 ENOG4105FDK ABC transporter CUC43_02575 ENOG4108JYZ YitT family CUC43_02580 ENOG41069ZM Protein of unknown function (DUF2624) CUC43_02605 ENOG4105EGD dinuclear metal center protein, YbgI family CUC43_02620 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CUC43_02625 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CUC43_02665 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CUC43_02670 ENOG4105KG3 cytidine deaminase CUC43_02675 ENOG4107YR5 Diacylglycerol kinase CUC43_02685 ENOG4105CTJ Metal Dependent Phosphohydrolase CUC43_02690 ENOG4105C9A Phoh family CUC43_02705 ENOG41068P3 sporulation protein YqfC CUC43_02710 ENOG4105KTH gatB Yqey CUC43_02730 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CUC43_02735 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CUC43_02765 ENOG4105CSA Coproporphyrinogen iii oxidase CUC43_02770 ENOG4105KVH Transcriptional regulator CUC43_02795 ENOG4105TQK DNA polymerase iii, delta' subunit CUC43_02805 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CUC43_02810 ENOG4108UK2 deaminase CUC43_02815 ENOG4105KQC Competence protein CUC43_02825 ENOG4105DXX methyltransferase CUC43_02835 ENOG4108WF2 Metal Dependent Phosphohydrolase CUC43_02845 ENOG410812S Rna-binding protein CUC43_02855 ENOG4105CQW ribosome biogenesis GTPase YqeH CUC43_02860 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CUC43_02875 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CUC43_02910 ENOG4105G6Z alkaline phosphatase CUC43_02920 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CUC43_02925 ENOG4108MUZ hydrolase CUC43_02960 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CUC43_02965 ENOG4105MIR Phenylalanine 4-monooxygenase CUC43_02975 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CUC43_03015 ENOG4105S6R Iron-hydroxamate transporter permease subunit CUC43_03020 ENOG4108V5C ABC transporter CUC43_03035 ENOG4108EKI Dehydrogenase CUC43_03040 ENOG4105C28 cystathionine CUC43_03070 ENOG4107XRG penicillin-binding protein CUC43_03085 ENOG4105CFP Peptidase U32 CUC43_03090 ENOG4105XYU peptidase (U32 family) CUC43_03095 ENOG4108VQJ O-methyltransferase CUC43_03100 ENOG4105HHA aminodeoxychorismate lyase CUC43_03130 ENOG4105C02 permease CUC43_03145 ENOG41060CR CUC43_03150 ENOG4105C7H Helicase, RecD TraA family CUC43_03165 ENOG4105C3J Cysteine desulfurase CUC43_03175 ENOG4105D1H recombination factor protein RarA CUC43_03180 ENOG4108VCI transcription factor, rsfa family CUC43_03190 ENOG4105CUZ uba thif-type nad fad binding protein CUC43_03220 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CUC43_03230 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CUC43_03235 ENOG41076HS cation diffusion facilitator family transporter CUC43_03240 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CUC43_03250 ENOG4105CKP Polysaccharide Biosynthesis Protein CUC43_03255 ENOG4108QG2 Membrane CUC43_03265 ENOG41085W3 Transposase CUC43_03275 ENOG4105VIE preprotein translocase, subunit YajC CUC43_03290 ENOG41061AI Protein of unknown function (DUF2905) CUC43_03305 ENOG4108HUF Transporter CUC43_03315 ENOG4108IPJ Membrane CUC43_03320 ENOG41082BM Transcriptional regulator, arsr family CUC43_03345 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CUC43_03350 ENOG4108IYU L-aspartate oxidase CUC43_03365 ENOG4108RPX mosc domain containing protein CUC43_03375 ENOG4105CQC Prephenate dehydratase CUC43_03395 ENOG4105EWM Histidine kinase CUC43_03420 ENOG4105X36 (ribosomal) protein CUC43_03430 ENOG4105C03 ribonuclease CUC43_03445 ENOG4107QMS site-determining protein CUC43_03460 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CUC43_03465 ENOG4105DFF Rod shape-determining protein mreb CUC43_03490 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CUC43_03505 ENOG41068KH stage VI sporulation protein D CUC43_03515 ENOG4105D52 delta-aminolevulinic acid dehydratase CUC43_03540 ENOG4105K56 Transcriptional regulator CUC43_03560 ENOG4108IUQ atp-dependent protease CUC43_03590 ENOG4108QCI YvbH-like oligomerisation region CUC43_03630 ENOG4105M59 Phosphodiesterase, mj0936 family CUC43_03645 ENOG4108XJQ germination protein CUC43_03655 ENOG4108PCX Major Facilitator CUC43_03665 ENOG4105KBX Transcriptional regulator, TetR family CUC43_03675 ENOG4105PFC Transcriptional regulator CUC43_03685 ENOG4105DZC cytosine deaminase CUC43_03690 ENOG41067S9 phage shock protein C, PspC CUC43_03695 ENOG4108JCI Transcriptional regulator CUC43_03705 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CUC43_03710 ENOG4108Z40 Transcriptional regulator CUC43_03715 ENOG4105RHA ABC transporter, permease CUC43_03720 ENOG4108IUX (ABC) transporter CUC43_03725 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CUC43_03730 ENOG4105ER2 Ompa motb domain protein CUC43_03735 ENOG4105E14 MotA TolQ exbB proton channel CUC43_03745 ENOG4108VXD carboxy-peptidase CUC43_03755 ENOG4105E33 succinate dehydrogenase CUC43_03765 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CUC43_03780 ENOG4105K63 Thioredoxin CUC43_03785 ENOG4105C10 Electron transfer flavoprotein CUC43_03790 ENOG4105BZJ Electron transfer flavoprotein CUC43_03795 ENOG41060WC Enoyl-CoA hydratase CUC43_03800 ENOG4107Z3H Transcriptional regulator, TetR family CUC43_03805 ENOG4105CEY Amp-dependent synthetase and ligase CUC43_03855 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CUC43_03870 ENOG4105DR4 Methyltransferase CUC43_03880 ENOG4105KFN sortase, SrtB family CUC43_03885 ENOG4105E0A ABC, transporter CUC43_03900 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CUC43_03910 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) CUC43_03920 ENOG4105FE9 pseudouridine synthase CUC43_03935 ENOG4105DCG PHP domain protein CUC43_03950 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CUC43_03970 ENOG4105C5S asparaginyl-tRNA synthetase CUC43_03975 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CUC43_03985 ENOG4108RWN rrna methyltransferase CUC43_04005 ENOG4105C0R drug resistance transporter emrb qaca subfamily CUC43_04010 ENOG4105CW7 secretion protein, HlyD family CUC43_04015 ENOG4108JGH Tetr family transcriptional regulator CUC43_04020 ENOG4105CN9 Peptidase m42 family protein CUC43_04040 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CUC43_04045 ENOG4105C22 threonyL-tRNA synthetase CUC43_04050 ENOG4108TDW sporulation protein YtxC CUC43_04070 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CUC43_04080 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CUC43_04085 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CUC43_04100 ENOG4105C2M dna polymerase I CUC43_04105 ENOG4105BZU Histidine kinase CUC43_04110 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CUC43_04135 ENOG4108HMX isocitrate dehydrogenase (NADP) CUC43_04140 ENOG4105BZN citrate synthase CUC43_04155 ENOG4108REF Sporulation integral membrane protein ytvi CUC43_04160 ENOG4105FS0 cytoplasmic membrane protein CUC43_04185 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CUC43_04190 ENOG4105C6K Malic enzyme CUC43_04195 ENOG4105C0B DNA polymerase III (alpha subunit) CUC43_04200 ENOG4105VV2 CUC43_04210 ENOG4105SFS phosphoesterase RecJ domain protein CUC43_04245 ENOG4105DC7 peptidase M24 CUC43_04300 ENOG41082W1 Cupin 2, conserved barrel domain protein CUC43_04310 ENOG4105VZ8 Transcriptional regulator CUC43_04330 ENOG4107YZX Universal stress protein CUC43_04380 ENOG4108JYZ YitT family CUC43_04410 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CUC43_04415 ENOG4105KBJ sporulation protein ytfj CUC43_04430 ENOG4105EFZ amidohydrolase CUC43_04440 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CUC43_04470 ENOG4106KR7 LysR family Transcriptional regulator CUC43_04480 ENOG4105U5Y Transcriptional regulator CUC43_04490 ENOG4105C28 cystathionine CUC43_04545 ENOG4105EMN RNA polymerase sigma factor CUC43_04565 ENOG4105F1V Acetoin utilization protein CUC43_04570 ENOG4105W87 Cbs domain CUC43_04575 ENOG4105DGU Histone deacetylase CUC43_04580 ENOG4106HB6 Alpha beta hydrolase CUC43_04590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CUC43_04595 ENOG4105BZU Histidine kinase CUC43_04605 ENOG41085W3 Transposase CUC43_04615 ENOG4107SNB ankyrin repeat protein YahD CUC43_04620 ENOG4105EP9 oxidoreductase CUC43_04650 ENOG4105ETE Transcriptional regulator (LacI family CUC43_04675 ENOG4105C88 aminopeptidase CUC43_04705 ENOG4108IPJ Membrane CUC43_04715 ENOG4105K7K Transcriptional regulator CUC43_04750 ENOG4108VDD TRNA binding domain protein CUC43_04785 ENOG4105C8F Beta-lactamase domain protein CUC43_04800 ENOG4108V15 phosphotransferase enzyme family CUC43_04805 ENOG4108IUM Glycogen debranching enzyme CUC43_04820 ENOG4107QSE Dipeptidase CUC43_04825 ENOG4105YW5 deoR family transcriptional regulator CUC43_04840 ENOG4105CBX hi0933 family CUC43_04885 ENOG4108VJ1 Transcriptional regulator (CarD family CUC43_04890 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CUC43_04910 ENOG4108ZAF Molybdopterin CUC43_04915 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CUC43_04920 ENOG4105CVM Molybdenum cofactor synthesis domain protein CUC43_04930 ENOG4105D06 uba thif-type nad fad binding protein CUC43_04935 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CUC43_04960 ENOG41085GJ domain protein CUC43_04970 ENOG4105DWV Homoserine O-trans-acetylase CUC43_04995 ENOG4108B31 Spore germination protein CUC43_05025 ENOG410605W Major Facilitator CUC43_05045 ENOG4105NCW Trka-c domain protein CUC43_05060 ENOG4105C19 ABC transporter CUC43_05085 ENOG4105N5T Radical SAM Protein CUC43_05095 ENOG4105DA5 (ABC) transporter CUC43_05130 ENOG4105E8V Alpha Beta Hydrolase Fold protein CUC43_05135 ENOG4108Z0R Transferase CUC43_05140 ENOG4105YVM Phosphoesterase, PA-phosphatase related CUC43_05145 ENOG4105BZF Glycosyl transferase (Group 1 CUC43_05155 ENOG4108RIR Molybdenum cofactor biosynthesis protein CUC43_05250 ENOG4105BZU Histidine kinase CUC43_05255 ENOG4105BZU Histidine kinase CUC43_05260 ENOG4107S9D Alpha beta hydrolase CUC43_05265 ENOG4107T7U Sulfatase CUC43_05280 ENOG4105D2X ABC transporter substrate-binding protein CUC43_05290 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CUC43_05305 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CUC43_05365 ENOG4108V2W Carbonate dehydratase CUC43_05370 ENOG4105C4M (Ubiquinol oxidase) subunit I CUC43_05375 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CUC43_05430 ENOG41087YS Phage shock protein A CUC43_05470 ENOG4105BZU Histidine kinase CUC43_05475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_05500 ENOG4108UGV hypoxanthine phosphoribosyltransferase CUC43_05505 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CUC43_05535 ENOG4105C19 ABC transporter CUC43_05570 ENOG4107ZTW SNARE associated Golgi CUC43_05605 ENOG4105C19 ABC transporter CUC43_05610 ENOG41086D8 Transcriptional regulator CUC43_05620 ENOG41082BM Transcriptional regulator, arsr family CUC43_05670 ENOG4105C6Z Gluconate CUC43_05675 ENOG4105FDP GntR family transcriptional regulator CUC43_05695 ENOG41069H0 dihydroorotase EC 3.5.2.3 CUC43_05715 ENOG4105DTQ mandelate racemase muconate lactonizing CUC43_05730 ENOG4108IPT Naphthoate synthase CUC43_05735 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CUC43_05745 ENOG4105E4F Isochorismate synthase CUC43_05750 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CUC43_05760 ENOG4105VEQ Cold shock protein CUC43_05815 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CUC43_05830 ENOG4105EMN RNA polymerase sigma factor CUC43_05925 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CUC43_05960 ENOG4105KT7 mgtC SapB transporter CUC43_05965 ENOG4107PBV potassium channel CUC43_05985 ENOG4105WG9 Conserved Protein CUC43_05995 ENOG4105CHM Aminotransferase CUC43_06000 ENOG4108ZB6 transcriptional regulator AsnC family CUC43_06005 ENOG4105C5I Dehydrogenase CUC43_06010 ENOG4108MUZ hydrolase CUC43_06020 ENOG4105C87 Aminotransferase class I and II CUC43_06030 ENOG4105Y38 Kinase-associated protein B CUC43_06040 ENOG4107R3E Citrate transporter CUC43_06060 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CUC43_06065 ENOG4105KA0 thioesterase Superfamily protein CUC43_06080 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CUC43_06100 ENOG41069ER domain protein CUC43_06115 ENOG4105CEP NADH dehydrogenase CUC43_06145 ENOG4105EWC Purine nucleoside phosphorylase CUC43_06175 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CUC43_06245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CUC43_06255 ENOG4105CAR Terminase, large subunit CUC43_06370 ENOG4108IMY Transcriptional regulator CUC43_06415 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CUC43_06445 ENOG4105C4B ABC transporter, permease CUC43_06450 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CUC43_06475 ENOG41083MR nifu domain-containing protein CUC43_06490 ENOG4108W5N phosphatidylglycerophosphatase a CUC43_06505 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CUC43_06520 ENOG4105DYS nad(p)h dehydrogenase (quinone) CUC43_06530 ENOG4105D4U had-superfamily hydrolase, subfamily iia CUC43_06545 ENOG4105CBT Fructose-1,6-bisphosphatase CUC43_06565 ENOG4105MMD transcriptional regulator CUC43_06570 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CUC43_06575 ENOG4107TXC Transcriptional regulator CUC43_06580 ENOG41090T1 Membrane CUC43_06605 ENOG4105FAA peptidase M23 CUC43_06615 ENOG4105KZD Domain of unknown function (DUF1805) CUC43_06620 ENOG4107R8B 5'-nucleotidase CUC43_06640 ENOG4105DIW FeS assembly protein SUFB CUC43_06645 ENOG4108UNV SUF system FeS assembly protein, NifU family CUC43_06650 ENOG4105C9B Cysteine desulfurase CUC43_06655 ENOG4105JRK feS assembly protein SufD CUC43_06660 ENOG4105C3K feS assembly ATPase SufC CUC43_06665 ENOG4105D01 (LipO)protein CUC43_06670 ENOG4105D01 (LipO)protein CUC43_06675 ENOG4108UMI ABC transporter, permease CUC43_06705 ENOG41080E8 Transcriptional regulator, Spx MgsR family CUC43_06785 ENOG4108W8B Beta-lactamase domain protein CUC43_06795 ENOG41085W3 Transposase CUC43_06800 ENOG4105C1G acyl-Coa dehydrogenase CUC43_06810 ENOG4105CHU acetyl-coa acetyltransferase CUC43_06830 ENOG4105DZ1 carboxypeptidase CUC43_06850 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CUC43_06870 ENOG4108SUT Major Facilitator Superfamily CUC43_06875 ENOG4107R7I amino acid CUC43_06890 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CUC43_06900 ENOG4107AYK membrAne CUC43_06945 ENOG4107ZTW SNARE associated Golgi CUC43_06960 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_06965 ENOG4105BZU Histidine kinase CUC43_06985 ENOG4105C8Q Methyl-accepting chemotaxis CUC43_06990 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CUC43_06995 ENOG4105VG1 fes assembly suf system protein CUC43_07000 ENOG4105D4Y metalloprotease CUC43_07020 ENOG4107T5V SNARE associated Golgi CUC43_07025 ENOG4107S91 Sodium hydrogen exchanger CUC43_07030 ENOG4105NCW Trka-c domain protein CUC43_07045 ENOG4108RMU ferritin dps family protein CUC43_07060 ENOG4108URH decarboxylase CUC43_07070 ENOG41090A1 ferritin CUC43_07080 ENOG4105D9N nucleoside CUC43_07085 ENOG4105D9N nucleoside CUC43_07100 ENOG4108RYK Nad-dependent epimerase dehydratase CUC43_07120 ENOG4105CV8 reductase CUC43_07125 ENOG4105F27 Major Facilitator CUC43_07130 ENOG4105KVH Transcriptional regulator CUC43_07145 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CUC43_07150 ENOG4105D4A Cell wall formation (By similarity) CUC43_07160 ENOG4105C8Q Methyl-accepting chemotaxis CUC43_07170 ENOG4105WMR Protein CrcB homolog CUC43_07190 ENOG4108MK9 spermidine N(1)-acetyltransferase CUC43_07195 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CUC43_07220 ENOG4108IPW abc transporter atp-binding protein CUC43_07225 ENOG4105CM4 permease protein CUC43_07260 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CUC43_07270 ENOG4105XZU Preprotein translocase, subunit SecG CUC43_07275 ENOG41067MG lrgb family CUC43_07290 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CUC43_07325 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CUC43_07335 ENOG4105RHA ABC transporter, permease CUC43_07340 ENOG4108IUX (ABC) transporter CUC43_07345 ENOG4105BZU Histidine kinase CUC43_07370 ENOG41090VF Stage v sporulation protein ac CUC43_07375 ENOG4105CZ3 stage V sporulation protein ad CUC43_07390 ENOG4108QY0 Membrane CUC43_07395 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CUC43_07410 ENOG4105KRI phosphocarrier protein (HPr CUC43_07420 ENOG4105CHW UPF0052 protein CUC43_07425 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CUC43_07430 ENOG4108Z4K mutator MutT protein CUC43_07440 ENOG4105C3M thioredoxin reductase CUC43_07450 ENOG4108S4C acetyltransferase CUC43_07470 ENOG41086DT Membrane protein of unknown function CUC43_07480 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CUC43_07500 ENOG4107TXC Transcriptional regulator CUC43_07530 ENOG4105HMI Membrane CUC43_07535 ENOG4105DUM transcriptional regulator, lysR family CUC43_07545 ENOG4108WS4 fmn reductase CUC43_07560 ENOG4105BZ1 (ABC) transporter CUC43_07575 ENOG4105CN1 protease CUC43_07580 ENOG4105CRP Part of the ABC transporter FtsEX involved in CUC43_07585 ENOG4105CAK Cell division ATP-binding protein ftsE CUC43_07605 ENOG4105MS2 ribosomal subunit Interface protein CUC43_07610 ENOG4105VEQ Cold shock protein CUC43_07615 ENOG41081UC Inherit from COG: Competence protein CUC43_07630 ENOG4105KVH Transcriptional regulator CUC43_07645 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CUC43_07650 ENOG4108KGH TRANSCRIPTIONal CUC43_07655 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CUC43_07660 ENOG4105C6Y Udp-glucose 6-dehydrogenase CUC43_07665 ENOG4105ESV Glycosyl transferase, family 4 CUC43_07675 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CUC43_07695 ENOG4105F8D glycoside hydrolase family 4 CUC43_07700 ENOG4105VCP PTS System CUC43_07705 ENOG4105CK1 PTS System CUC43_07715 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CUC43_07725 ENOG4105VCP PTS System CUC43_07735 ENOG4105VZJ PTS System CUC43_07745 ENOG41085W3 Transposase CUC43_07760 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CUC43_07765 ENOG4105ECB domain protein CUC43_07770 ENOG4107RSM transcriptional regulator CUC43_07805 ENOG4105DAA L-lactate CUC43_07815 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CUC43_07830 ENOG4105E0M Sulfatase CUC43_07860 ENOG4107R8N Glycosyl transferase, family 2 CUC43_07870 ENOG4105C94 Transporter CUC43_07880 ENOG41069ER domain protein CUC43_07905 ENOG4105KBK Zinc finger, swim domain protein CUC43_07910 ENOG4105C0D helicase CUC43_07955 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CUC43_07970 ENOG4107RBB ABC transporter, permease CUC43_07975 ENOG4105C19 ABC transporter CUC43_07985 ENOG4105CXY transporter CUC43_08000 ENOG4105BZU Histidine kinase CUC43_08005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_08010 ENOG4105CMR udp-glucose 4-epimerase CUC43_08015 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CUC43_08035 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CUC43_08040 ENOG4105EY8 ABC transporter CUC43_08090 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CUC43_08105 ENOG4105FRN stage II sporulation protein CUC43_08120 ENOG4105DY9 regulatoR CUC43_08125 ENOG4105CEY Amp-dependent synthetase and ligase CUC43_08145 ENOG4106778 Protein of unknown function (DUF1146) CUC43_08150 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CUC43_08155 ENOG4105C8S subunit m CUC43_08160 ENOG4105D65 subunit l CUC43_08185 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CUC43_08190 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CUC43_08200 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CUC43_08205 ENOG4105BZU Histidine kinase CUC43_08255 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CUC43_08260 ENOG41062M3 atp synthase CUC43_08290 ENOG4108YZG isomerase CUC43_08310 ENOG4108VGI doxx family CUC43_08315 ENOG4107XC4 flavin reductase domain protein, FMN-binding CUC43_08330 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CUC43_08340 ENOG4108ZXQ stage ii sporulation protein r CUC43_08345 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CUC43_08350 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CUC43_08370 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CUC43_08375 ENOG4105CBT Fructose-1,6-bisphosphatase CUC43_08385 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CUC43_08420 ENOG4105C1G acyl-Coa dehydrogenase CUC43_08425 ENOG4105C1G acyl-Coa dehydrogenase CUC43_08430 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CUC43_08440 ENOG4105DF6 Fe-S oxidoreductase CUC43_08455 ENOG4105BZU Histidine kinase CUC43_08485 ENOG4105BZU Histidine kinase CUC43_08490 ENOG4105KCT ABC transporter CUC43_08495 ENOG4108M15 ABC transporter CUC43_08500 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CUC43_08510 ENOG4105IIU Aminopeptidase CUC43_08540 ENOG410684U Domain of unknown function (DUF1934) CUC43_08560 ENOG4105CYW agmatinase CUC43_08570 ENOG4105DXB Major Facilitator superfamily CUC43_08575 ENOG4107SWG transcriptional regulator MERR family CUC43_08580 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CUC43_08585 ENOG4105BZ4 penicillin-binding protein CUC43_08590 ENOG4108XFG YwhD family CUC43_08595 ENOG4108Z4T Peptidase M50 CUC43_08600 ENOG41069HH 4-oxalocrotonate tautomerase CUC43_08605 ENOG4105DCI Phosphohydrolase CUC43_08610 ENOG4108V5C ABC transporter CUC43_08615 ENOG4105E0A ABC, transporter CUC43_08620 ENOG4105EHG Permease protein CUC43_08625 ENOG4105DQ5 transport system permease protein CUC43_08635 ENOG4108VCI transcription factor, rsfa family CUC43_08650 ENOG4108IJ2 phosphate acetyltransferase CUC43_08665 ENOG4108VKI Cell wall hydrolase CUC43_08685 ENOG4107SVH Potassium channel protein CUC43_08695 ENOG410667J hydrolase CUC43_08700 ENOG4105VCH membrane CUC43_08710 ENOG4108TU7 Inherit from COG: (ABC) transporter CUC43_08715 ENOG4105CJ1 ABC, transporter CUC43_08720 ENOG41090WU lipolytic protein G-D-S-L family CUC43_08735 ENOG4105D6E homoserine dehydrogenase CUC43_08775 ENOG4105WH1 Two component transcriptional regulator luxr family CUC43_08780 ENOG4105BZU Histidine kinase CUC43_08785 ENOG4105DWF phosphomethylpyrimidine kinase CUC43_08790 ENOG4105BZU Histidine kinase CUC43_08795 ENOG4105VCD cytoplasmic protein CUC43_08815 ENOG4105DY9 regulatoR CUC43_08820 ENOG41079KZ Major Facilitator Superfamily CUC43_08840 ENOG4105EN6 Membrane CUC43_08845 ENOG4106YBV Methyl-accepting chemotaxis CUC43_08855 ENOG4108S4H thioesterase Superfamily protein CUC43_08870 ENOG4105JEU Glycosyl transferase, family 2 CUC43_08875 ENOG4105C5H ABC transporter CUC43_08900 ENOG4105CKK Glycosyl transferase, family 2 CUC43_08905 ENOG41067SE Tetr family transcriptional regulator CUC43_08915 ENOG4105E0X reductase CUC43_08920 ENOG4106F5Q Membrane CUC43_08935 ENOG4105DY9 regulatoR CUC43_08940 ENOG4108HRK Histidine kinase CUC43_08945 ENOG4107RGD Major Facilitator superfamily CUC43_08965 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CUC43_08975 ENOG4105IW1 AmiS UreI transporter CUC43_08985 ENOG4105CMR udp-glucose 4-epimerase CUC43_08990 ENOG4108UT2 hemolysin iii CUC43_09005 ENOG4105C1J atp-dependent rna helicase CUC43_09020 ENOG4105DPN Oligoendopeptidase f CUC43_09045 ENOG4105C0H protease CUC43_09050 ENOG4105Q2H domain protein CUC43_09065 ENOG4105BZU Histidine kinase CUC43_09070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_09100 ENOG4105CDU Replicative dna helicase CUC43_09110 ENOG4105BZR domain protein CUC43_09115 ENOG4108XMW Membrane CUC43_09125 ENOG4108UUM single-stranded DNA-binding protein CUC43_09135 ENOG4105C3G gtp-binding protein CUC43_09140 ENOG4105VDK protein, conserved in bacteria CUC43_09145 ENOG4105D8X mechanosensitive ion channel CUC43_09150 ENOG4108ZDA Sporulation protein YyaC CUC43_09155 ENOG4105FA0 parb-like partition protein CUC43_09160 ENOG4107QJE Chromosome Partitioning Protein CUC43_09190 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CUC43_09210 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CUC43_09215 ENOG410848D S4 domain protein YaaA CUC43_09230 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CUC43_09265 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CUC43_09300 ENOG4105ZMH deoxynucleoside kinase CUC43_09310 ENOG4105GTG Isochorismatase CUC43_09320 ENOG4108Z6B deaminase CUC43_09330 ENOG4105C6E dna polymerase iii CUC43_09350 ENOG41067KS pro-sigma K processing CUC43_09385 ENOG4105CXN decarboxylase CUC43_09395 ENOG4105FA2 dna polymerase iii CUC43_09400 ENOG4105MA4 psp1 domain protein CUC43_09410 ENOG41060K3 Methyltransferase CUC43_09420 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CUC43_09425 ENOG4105KRN Transcriptional regulator, abrb family CUC43_09430 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CUC43_09435 ENOG4105F8V Hydrolase, tatD family CUC43_09440 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CUC43_09450 ENOG4105XFA sporulation peptidase YabG CUC43_09455 ENOG4105W42 Veg protein CUC43_09470 ENOG4105DFT pur operon repressor CUC43_09480 ENOG4105KME endoribonuclease L-psp CUC43_09495 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CUC43_09510 ENOG4108JA2 transcriptioN-repair coupling factor CUC43_09515 ENOG4108M14 stage v sporulation protein t CUC43_09525 ENOG4108IY2 MazG family CUC43_09530 ENOG41082I2 s4 domain protein CUC43_09535 ENOG4105VYY sporulation protein yabp CUC43_09550 ENOG41060GV RNA binding s1 domain protein CUC43_09575 ENOG4108UGV hypoxanthine phosphoribosyltransferase CUC43_09580 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CUC43_09595 ENOG4105C6T cysteine synthase CUC43_09600 ENOG4105CRQ synthase (Component I) CUC43_09605 ENOG4105DDQ anthranilate synthase CUC43_09610 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CUC43_09615 ENOG4105EEI dihydropteroate synthase CUC43_09620 ENOG4105KRF dihydroneopterin aldolase CUC43_09625 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CUC43_09635 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CUC43_09725 ENOG4108Z0C Uvrb UvrC protein CUC43_09740 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CUC43_09750 ENOG4105CTP PilT protein domain protein CUC43_09770 ENOG4105D7W serine acetyltransferase CUC43_09785 ENOG4105C2N RNA methyltransferase TrmH family group 3 CUC43_09790 ENOG4105M0M Tetracycline resistance protein CUC43_09795 ENOG4105QIV RNA polymerase CUC43_09810 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CUC43_09835 ENOG4107Y49 methyltransferase CUC43_09850 ENOG4105XPM ribosomal protein CUC43_09960 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CUC43_09985 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CUC43_09995 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CUC43_10005 ENOG41067V7 50S ribosomal protein L36 CUC43_10040 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CUC43_10070 ENOG4105D1F ATP-binding protein CUC43_10085 ENOG4108NMV polysaccharide deacetylase CUC43_10170 ENOG4105C8B TIGR00159 family CUC43_10175 ENOG4107U5W ybbr family CUC43_10195 ENOG4108VQT Alpha beta hydrolase fold protein CUC43_10205 ENOG4105CMG Carbohydrate kinase CUC43_10215 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CUC43_10250 ENOG4108PSK reductase CUC43_10255 ENOG4108UMI ABC transporter, permease CUC43_10260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CUC43_10265 ENOG4105D01 (LipO)protein CUC43_10270 ENOG4105EE1 crotonyl-CoA reductase CUC43_10280 ENOG4105IQ5 FAD linked oxidase domain protein CUC43_10295 ENOG4105C2C drug resistance transporter, Bcr CflA CUC43_10310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CUC43_10315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CUC43_10320 ENOG4105C3U ABC transporter CUC43_10325 ENOG4108JQ7 (ABC) transporter CUC43_10345 ENOG4108J59 Extracellular solute-binding protein, family 5 CUC43_10350 ENOG4108J59 Extracellular solute-binding protein, family 5 CUC43_10360 ENOG4105II7 pyrroline-5-carboxylate reductase CUC43_10390 ENOG4105E0C molybdate abc transporter CUC43_10395 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CUC43_10400 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CUC43_10440 ENOG4105F6E Acyl-transferase CUC43_10460 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CUC43_10475 ENOG4108RE7 deoxyribonuclease CUC43_10485 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CUC43_10510 ENOG4105C5H ABC transporter CUC43_10515 ENOG4105BZU Histidine kinase CUC43_10520 ENOG4105WH1 Two component transcriptional regulator luxr family CUC43_10525 ENOG4105CJ1 ABC, transporter CUC43_10530 ENOG41090VJ ABC-2 type transporter CUC43_10535 ENOG4108KYE ABC-2 type transporter CUC43_10550 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CUC43_10560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CUC43_10565 ENOG4105C3U ABC transporter CUC43_10570 ENOG4108JQ7 (ABC) transporter CUC43_10575 ENOG410667J hydrolase CUC43_10615 ENOG4105ERH Fumarylacetoacetate hydrolase CUC43_10630 ENOG4105CUB amino acid CUC43_10640 ENOG4105CPF Cell wall formation (By similarity) CUC43_10645 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CUC43_10670 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CUC43_10675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CUC43_10685 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CUC43_10785 ENOG4105K8N protein family UPF0079, ATPase CUC43_10790 ENOG41072GX Peptidase M22 Glycoprotease CUC43_10795 ENOG410801F ribosomal-protein-alanine acetyltransferase CUC43_10805 ENOG4105C5H ABC transporter CUC43_10820 ENOG4108TYN CAAX amino terminal protease family protein CUC43_10830 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CUC43_10850 ENOG4105C7N Xanthine uracil vitamin C permease CUC43_10860 ENOG4105BZU Histidine kinase CUC43_10885 ENOG4107ZXU DSBA oxidoreductase CUC43_10915 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CUC43_10945 ENOG4108SHN Glycosyl transferase, family 2 CUC43_10985 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CUC43_11005 ENOG4105SX7 Transporter CUC43_11030 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CUC43_11035 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CUC43_11040 ENOG4105C83 adenylosuccinate lyase CUC43_11050 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CUC43_11075 ENOG4108V3E phosphoribosylglycinamide formyltransferase CUC43_11085 ENOG4105C12 Phosphoribosylglycinamide synthetase CUC43_11115 ENOG4105C4R Atp-dependent dna helicase CUC43_11145 ENOG4108W2Y isochorismatase CUC43_11160 ENOG4108UMI ABC transporter, permease CUC43_11165 ENOG4105D01 (LipO)protein CUC43_11195 ENOG410834F Transcriptional regulator CUC43_11200 ENOG4107I77 yiaA/B two helix domain CUC43_11220 ENOG4105CBD Diacylglycerol kinase CUC43_11225 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CUC43_11230 ENOG4108JPW Aminotransferase CUC43_11240 ENOG4105C26 Dehydrogenase CUC43_11245 ENOG4105KPY Small multidrug resistance protein CUC43_11280 ENOG4105D9N nucleoside CUC43_11285 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CUC43_11290 ENOG4105VTR Integrase CUC43_11300 ENOG4108IMY Transcriptional regulator CUC43_11310 ENOG4108IMY Transcriptional regulator CUC43_11355 ENOG4105KRN Transcriptional regulator, abrb family CUC43_11445 ENOG4105CNU cell division protein FtsK CUC43_11480 ENOG4105CAR Terminase, large subunit CUC43_11560 ENOG4105XSJ toxin secretion phage lysis holin CUC43_11565 ENOG41085W3 Transposase CUC43_11595 ENOG4105BZU Histidine kinase CUC43_11600 ENOG4108W15 Protein of unknown function (DUF1456) CUC43_11625 ENOG4105DTQ mandelate racemase muconate lactonizing CUC43_11635 ENOG4105DFD Na H antiporter CUC43_11660 ENOG4105D3R alkyl hydroperoxide reductase CUC43_11665 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CUC43_11670 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CUC43_11675 ENOG4107W7X Aldolase CUC43_11680 ENOG4105EHG Permease protein CUC43_11685 ENOG4105DQ5 transport system permease protein CUC43_11690 ENOG4108V5C ABC transporter CUC43_11720 ENOG4106UIA CUC43_11725 ENOG4106UIA CUC43_11765 ENOG410756H nucleotidyltransferase CUC43_11770 ENOG4105D2S major facilitator superfamily CUC43_11790 ENOG4105E5Q amino acid AbC transporter CUC43_11795 ENOG4105EAB amino acid AbC transporter CUC43_11805 ENOG4105C8Q Methyl-accepting chemotaxis CUC43_11810 ENOG4105DNP FAD linked oxidase domain protein CUC43_11820 ENOG4105CI1 PTS System CUC43_11855 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CUC43_11870 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CUC43_11930 ENOG41062JF Transcriptional regulator CUC43_11950 ENOG4105DEU major facilitator superfamily CUC43_11980 ENOG4108N0M stress protein CUC43_11985 ENOG4106FN3 tellurium resistance protein CUC43_11990 ENOG4106FN3 tellurium resistance protein CUC43_11995 ENOG4107TS3 membrane protein, TerC CUC43_12000 ENOG4108TTB tellurium resistance protein CUC43_12020 ENOG4105KJF protein tyrosine phosphatase CUC43_12030 ENOG4107U9T Pfam:Ribonuclease_BN CUC43_12040 ENOG4105C59 p-type ATPase CUC43_12045 ENOG4108IPJ Membrane CUC43_12055 ENOG4105C3F Signal peptidase i CUC43_12065 ENOG4107ZTW SNARE associated Golgi CUC43_12080 ENOG410606W general stress protein CUC43_12085 ENOG4105UPD Calcium Proton CUC43_12135 ENOG4108JUB Transcriptional regulator CUC43_12145 ENOG4108IQI permease CUC43_12180 ENOG4105CSV Glutaminase CUC43_12195 ENOG4108A04 Beta-lactamase CUC43_12215 ENOG4105CKK Glycosyl transferase, family 2 CUC43_12220 ENOG4107QQG Dehydrogenase CUC43_12225 ENOG4105C3I Nad-dependent epimerase dehydratase CUC43_12240 ENOG4105F1A Pyruvate formate-lyase CUC43_12260 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CUC43_12265 ENOG4105ECP epimerase CUC43_12300 ENOG41067AE Membrane-bound metal-dependent hydrolase CUC43_12305 ENOG4105CEN a g-specific adenine glycosylase CUC43_12310 ENOG4106BXE CUC43_12330 ENOG4105BZ1 (ABC) transporter CUC43_12335 ENOG4107NBY Membrane CUC43_12340 ENOG4105CBC glutamate synthase CUC43_12350 ENOG4108IUW ABC transporter CUC43_12370 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CUC43_12375 ENOG4105G5W regulator Fur family CUC43_12480 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CUC43_12490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CUC43_12590 ENOG4108JQC penicillin-binding protein 1A CUC43_12595 ENOG4107ZQN disulfide bond CUC43_12610 ENOG4105D7V transposase CUC43_12620 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CUC43_12630 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CUC43_12635 ENOG4105BZU Histidine kinase CUC43_12645 ENOG4105CYN Serine protein kinase CUC43_12670 ENOG4105C94 Transporter CUC43_12685 ENOG4105DZ6 Band 7 protein CUC43_12695 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CUC43_12700 ENOG4108V9W transcriptional regulatory protein CUC43_12705 ENOG4105D4T Citrate transporter CUC43_12730 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CUC43_12735 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CUC43_12740 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CUC43_12745 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CUC43_12750 ENOG4105BZ7 extracellular solute-binding protein family 1 CUC43_12770 ENOG4108STX response regulator CUC43_12775 ENOG4105US7 Histidine kinase CUC43_12800 ENOG4108MRH transcriptional regulatory protein CUC43_12810 ENOG4105C6K Malic enzyme CUC43_12820 ENOG4108UZ3 Transporter CUC43_12825 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CUC43_12835 ENOG4105BZU Histidine kinase CUC43_12840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_12850 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CUC43_12855 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CUC43_12860 ENOG4108JB9 formate dehydrogenase CUC43_12880 ENOG4105CUB amino acid CUC43_12890 ENOG4105C59 p-type ATPase CUC43_12895 ENOG4105DAP Nicotinate phosphoribosyltransferase CUC43_12925 ENOG41073R8 VanW family CUC43_12930 ENOG4108KGH TRANSCRIPTIONal CUC43_12935 ENOG4105D9N nucleoside CUC43_12940 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CUC43_12945 ENOG4105C37 (CBS) domain CUC43_12950 ENOG4108IJ0 Aspartate ammonia-lyase CUC43_12955 ENOG4105DAA L-lactate CUC43_12975 ENOG4105DUX Transporter CUC43_12980 ENOG4108MES Periplasmic binding protein CUC43_12985 ENOG4105DQ5 transport system permease protein CUC43_12990 ENOG4108IHU transport system permease protein CUC43_12995 ENOG4105E0A ABC, transporter CUC43_13000 ENOG4105DMQ Methyltransferase CUC43_13010 ENOG4105EXW epimerase dehydratase CUC43_13015 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CUC43_13025 ENOG4107T89 von Willebrand factor, type A CUC43_13030 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CUC43_13035 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CUC43_13050 ENOG4105BZU Histidine kinase CUC43_13055 ENOG4105D5Q Arginine ornithine antiporter CUC43_13060 ENOG4107414 GntR family transcriptional regulator CUC43_13065 ENOG4105C5Y PTS System CUC43_13070 ENOG4105CG3 alpha amylase, catalytic region CUC43_13085 ENOG4105E1K spore germination protein CUC43_13090 ENOG4108XG2 Histidine kinase CUC43_13095 ENOG4105WH1 Two component transcriptional regulator luxr family CUC43_13125 ENOG4105CRN Aminoglycoside phosphotransferase CUC43_13130 ENOG4105BZG amino acid carrier protein CUC43_13140 ENOG4105CDA abc transporter atp-binding protein CUC43_13145 ENOG4105CT1 (ABC) transporter CUC43_13150 ENOG4105EAD ABC transporter CUC43_13155 ENOG4105DRP amino acid AbC transporter CUC43_13160 ENOG4108IQI permease CUC43_13175 ENOG4105GFR rna polymerase sigma factor CUC43_13190 ENOG4105D29 Helix-turn-helix type 11 domain protein CUC43_13195 ENOG4105NAE bifunctional deaminase-reductase domain protein CUC43_13200 ENOG4105BZU Histidine kinase CUC43_13215 ENOG4105CHH sulfate transporter CUC43_13220 ENOG41068KF Universal stress protein CUC43_13230 ENOG4105DEF Extracellular solute-binding protein, family 5 CUC43_13240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CUC43_13245 ENOG4108JQ7 (ABC) transporter CUC43_13255 ENOG4105CXY transporter CUC43_13260 ENOG41067TZ transcriptional regulator, MarR family CUC43_13265 ENOG4105C0R drug resistance transporter emrb qaca subfamily CUC43_13270 ENOG4105ETE Transcriptional regulator (LacI family CUC43_13275 ENOG4108RVA ribokinase CUC43_13285 ENOG4105C2J ABC transporter CUC43_13290 ENOG4105CNN ABC, transporter CUC43_13295 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CUC43_13300 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CUC43_13365 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CUC43_13370 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CUC43_13375 ENOG41069ER domain protein CUC43_13380 ENOG4105VZ8 Transcriptional regulator CUC43_13385 ENOG4107D63 CUC43_13400 ENOG4105DUX Transporter CUC43_13410 ENOG4105D01 (LipO)protein CUC43_13415 ENOG4105FDT acyl-CoA dehydrogenase CUC43_13420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CUC43_13425 ENOG4108UMI ABC transporter, permease CUC43_13440 ENOG4105C85 amino acid CUC43_13445 ENOG4105C7N Xanthine uracil vitamin C permease CUC43_13460 ENOG4105MA6 gCN5-related N-acetyltransferase CUC43_13485 ENOG4105BZ9 Cytochrome C oxidase, subunit I CUC43_13490 ENOG4105E2S oxidase) subunit II CUC43_13510 ENOG4106CAD Protein of unknown function (DUF3311) CUC43_13515 ENOG4105E1V na solute symporter CUC43_13530 ENOG4108NHD germination protein CUC43_13540 ENOG4105CE1 Ferrous iron transport protein b CUC43_13545 ENOG4105CE1 Ferrous iron transport protein b CUC43_13550 ENOG4105CE1 Ferrous iron transport protein b CUC43_13555 ENOG4105CVA phosphate CUC43_13560 ENOG4105C8U phosphate abc transporter CUC43_13565 ENOG4105E2Z phosphate ABC transporter (Permease CUC43_13700 ENOG41080XQ Signal transduction protein with cbs domains CUC43_13735 ENOG4105ETU transcriptional activator (TenA CUC43_13745 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CUC43_13755 ENOG4108VEU Thiamine monophosphate synthase CUC43_13760 ENOG41080HI glycine oxidase CUC43_13775 ENOG4105D06 uba thif-type nad fad binding protein CUC43_13780 ENOG4105DWF phosphomethylpyrimidine kinase CUC43_13835 ENOG4108INS Transcriptional regulator CUC43_13850 ENOG4105C7N Xanthine uracil vitamin C permease CUC43_13860 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CUC43_13895 ENOG4108B31 Spore germination protein CUC43_13915 ENOG4107Y03 Nitroreductase CUC43_13920 ENOG4105ED1 spovr family CUC43_13930 ENOG4108TCS Glutamyl endopeptidase CUC43_13955 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CUC43_13960 ENOG4105XTG Pfam:DUF156 CUC43_13965 ENOG4105VFE sira family CUC43_13970 ENOG4107TPS domain protein CUC43_13975 ENOG4105VFE sira family CUC43_13980 ENOG4105VFE sira family CUC43_13990 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CUC43_13995 ENOG41087NI Sulfite exporter TauE/SafE CUC43_14005 ENOG4108KGH TRANSCRIPTIONal CUC43_14035 ENOG4105EMD TRANSCRIPTIONal CUC43_14040 ENOG4105VCP PTS System CUC43_14045 ENOG4105VZJ PTS System CUC43_14050 ENOG4105CK1 PTS System CUC43_14065 ENOG41069ER domain protein CUC43_14070 ENOG4107RBB ABC transporter, permease CUC43_14075 ENOG4105C19 ABC transporter CUC43_14105 ENOG4105WEF catalase CUC43_14140 ENOG4107T5V SNARE associated Golgi CUC43_14165 ENOG4105CUB amino acid CUC43_14170 ENOG4107RWR Sodium hydrogen exchanger CUC43_14180 ENOG4106KNT transcriptional regulator CUC43_14220 ENOG4108YXU transcriptional regulator AsnC family CUC43_14230 ENOG4105KPY Small multidrug resistance protein CUC43_14260 ENOG4105NF4 modulator of drug activity CUC43_14280 ENOG4105E5W Transporter CUC43_14290 ENOG4107RKG DJ-1/PfpI family CUC43_14295 ENOG4105CH6 catalase CUC43_14305 ENOG4105D5Q Arginine ornithine antiporter CUC43_14310 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CUC43_14320 ENOG4105C26 Dehydrogenase CUC43_14340 ENOG4105BZ1 (ABC) transporter CUC43_14345 ENOG4105BZ1 (ABC) transporter CUC43_14360 ENOG4105DRP amino acid AbC transporter CUC43_14365 ENOG4105CDA abc transporter atp-binding protein CUC43_14380 ENOG410839P CUC43_14415 ENOG4107FQX Alpha-acetolactate decarboxylase CUC43_14435 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CUC43_14445 ENOG4105D4P Coproporphyrinogen iii oxidase CUC43_14470 ENOG4105CHH sulfate transporter CUC43_14525 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CUC43_14535 ENOG4105CGU Enoyl-CoA hydratase CUC43_14555 ENOG4105DER m42 family CUC43_14575 ENOG4105CTU Proline racemase CUC43_14610 ENOG4105CDU Replicative dna helicase CUC43_14640 ENOG4105ESF Peptidoglycan binding domain protein CUC43_14660 ENOG41085W3 Transposase CUC43_14675 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CUC43_14700 ENOG4105ESF Peptidoglycan binding domain protein CUC43_14720 ENOG4105CSH Transporter CUC43_14725 ENOG41085W3 Transposase CUC43_14740 ENOG4108MRH transcriptional regulatory protein CUC43_14755 ENOG4105EKQ RNA-directed DNA polymerase CUC43_14790 ENOG4105CVR type I restriction-modification system CUC43_14800 ENOG4105DZR Type I site-specific deoxyribonuclease CUC43_14840 ENOG4105CDU Replicative dna helicase CUC43_14865 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CUC43_14870 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CUC43_14895 ENOG4108Z86 Glutamine amidotransferase CUC43_14915 ENOG4105C0R drug resistance transporter emrb qaca subfamily CUC43_15015 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CUC43_15040 ENOG4105CMT Dihydroxyacetone kinase CUC43_15055 ENOG4105CMT Dihydroxyacetone kinase CUC43_15070 ENOG410847I Transcriptional regulator, BadM Rrf2 family CUC43_15105 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CUC43_15175 ENOG4105C19 ABC transporter CUC43_15185 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CUC43_15205 ENOG41085W3 Transposase CUC43_15230 ENOG4105WN5 stage II sporulation protein CUC43_15240 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CUC43_15250 ENOG4108MJI response regulator CUC43_15255 ENOG4105BZU Histidine kinase CUC43_15260 ENOG4105BZU Histidine kinase CUC43_15285 ENOG4105K8R UPF0145 protein CUC43_15300 ENOG4105D7V transposase CUC43_15335 ENOG4107VRP DNA repair exonuclease CUC43_15340 ENOG4106D4I domain protein CUC43_15425 ENOG4108MUZ hydrolase CUC43_15455 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CUC43_15470 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CUC43_15490 ENOG4105EMN RNA polymerase sigma factor CUC43_15515 ENOG4105C57 major facilitator superfamily CUC43_15520 ENOG4105C0R drug resistance transporter emrb qaca subfamily CUC43_15530 ENOG4105EYF MMPL domain protein CUC43_15560 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CUC43_15590 ENOG4105K59 histidine triad (HIT) protein CUC43_15645 ENOG410905X membrane-flanked domain protein CUC43_15650 ENOG4105CKV Membrane CUC43_15695 ENOG410905X membrane-flanked domain protein CUC43_15700 ENOG4105CKV Membrane CUC43_15705 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CUC43_15710 ENOG4105BZ4 penicillin-binding protein CUC43_15720 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CUC43_15725 ENOG4105C1Q protoporphyrinogen oxidase CUC43_15755 ENOG4105ECB domain protein CUC43_15775 ENOG4106DF1 CUC43_15780 ENOG4105D29 Helix-turn-helix type 11 domain protein CUC43_15795 ENOG4106AXD CUC43_15800 ENOG4108RQ5 Beta-lactamase domain-containing protein CUC43_15805 ENOG4105DF9 Lipoate-protein, ligase CUC43_15815 ENOG4105CEY Amp-dependent synthetase and ligase CUC43_15825 ENOG41085W3 Transposase CUC43_15870 ENOG4105ENX hydrolase CUC43_15875 ENOG4107RN3 metallophosphoesterase CUC43_15885 ENOG4107TVP HD domain protein CUC43_15915 ENOG4108AEY RNA polymerase sigma factor CUC43_15920 ENOG41086D8 Transcriptional regulator CUC43_15930 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CUC43_15955 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CUC43_15975 ENOG4105ZU5 s-layer protein CUC43_15980 ENOG4107QP3 malate synthase g CUC43_15995 ENOG4105VEQ Cold shock protein CUC43_16015 ENOG4105XVF Competence transcription factor CUC43_16085 ENOG4105ERH Fumarylacetoacetate hydrolase CUC43_16110 ENOG4105CAQ asparagine synthetase CUC43_16120 ENOG4105CH6 catalase CUC43_16125 ENOG4105BZU Histidine kinase CUC43_16140 ENOG4107A6P CUC43_16160 ENOG4108VPT UPF0234 protein CUC43_16165 ENOG4105QNR S1 RNA binding domain protein CUC43_16170 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CUC43_16180 ENOG4107AYK membrAne CUC43_16185 ENOG41073B9 CUC43_16195 ENOG4108KP7 hydrolase CUC43_16210 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CUC43_16240 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CUC43_16245 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CUC43_16260 ENOG4105C31 Tryptophanyl-tRNA synthetase CUC43_16280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CUC43_16285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CUC43_16295 ENOG4108JQ7 (ABC) transporter CUC43_16300 ENOG4105UQX Mate efflux family protein CUC43_16325 ENOG4108ZCF integral membrane protein CUC43_16335 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CUC43_16345 ENOG4105DPN Oligoendopeptidase f CUC43_16360 ENOG4108Z18 K06886 hemoglobin CUC43_16365 ENOG4105MIX Adenylate cyclase CUC43_16370 ENOG4106EFP UPF0738 protein CUC43_16380 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CUC43_16385 ENOG4105EMS pseudouridine synthase CUC43_16405 ENOG4105K64 Glycosyl transferase, family 2 CUC43_16425 ENOG4107TVC Glycosyl transferase, family 2 CUC43_16445 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CUC43_16450 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CUC43_16460 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CUC43_16535 ENOG4105CK7 Sodium proline symporter CUC43_16545 ENOG4105CRQ synthase (Component I) CUC43_16550 ENOG4105DDQ anthranilate synthase CUC43_16570 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CUC43_16600 ENOG4105D7V transposase CUC43_16645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CUC43_16665 ENOG4105C7S Dehydrogenase CUC43_16675 ENOG4105VZ8 Transcriptional regulator CUC43_16815 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CUC43_16830 ENOG4105DZ1 carboxypeptidase CUC43_16835 ENOG4105VFR signal peptidase CUC43_16870 ENOG4105C26 Dehydrogenase CUC43_16880 ENOG4105F38 ABC transporter, permease CUC43_16885 ENOG4105D38 putrescine abc transporter CUC43_16890 ENOG4107RUE extracellular solute-binding protein family 1 CUC43_16900 ENOG4105EYF MMPL domain protein CUC43_16910 ENOG4108YBP pseudouridine synthase CUC43_16920 ENOG4105K4I Scp-like extracellular CUC43_16925 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CUC43_16930 ENOG4105CQB FAD linked oxidase domain protein CUC43_16945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_16950 ENOG4105BZU Histidine kinase CUC43_16955 ENOG4105JXH GntR family transcriptional regulator CUC43_16975 ENOG4106A3R peptidase CUC43_16985 ENOG4108QTI )-transporter CUC43_16990 ENOG4107TS3 membrane protein, TerC CUC43_16995 ENOG4105CZN Potassium uptake protein CUC43_17000 ENOG410681C small acid-soluble spore protein CUC43_17005 ENOG4108Z7G MaoC domain protein dehydratase CUC43_17025 ENOG4105CHR reductase CUC43_17060 ENOG4105C4Y ABC transporter CUC43_17065 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CUC43_17070 ENOG4107RCV ABC transporter, permease CUC43_17090 ENOG4105E98 transcriptional regulator DeoR family CUC43_17105 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CUC43_17115 ENOG4105PXI polysaccharide deacetylase CUC43_17125 ENOG4105BZU Histidine kinase CUC43_17130 ENOG41090MY MarR family Transcriptional regulator CUC43_17140 ENOG4106DF1 CUC43_17150 ENOG4105BZU Histidine kinase CUC43_17160 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CUC43_17165 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CUC43_17210 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CUC43_17225 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CUC43_17230 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CUC43_17235 ENOG4105CZV ABC transporter CUC43_17245 ENOG4105CJ1 ABC, transporter CUC43_17285 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CUC43_17290 ENOG4105EA8 2-Nitropropane dioxygenase CUC43_17295 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CUC43_17305 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CUC43_17330 ENOG4105NQC Flavodoxin CUC43_17370 ENOG4107QMU Mate efflux family protein CUC43_17410 ENOG4105CZN Potassium uptake protein CUC43_17415 ENOG41063Y9 CUC43_17420 ENOG4105KBJ sporulation protein ytfj CUC43_17450 ENOG4105CM2 brancheD-chain amino acid aminotransferase CUC43_17455 ENOG4105C7K acetolactate synthase CUC43_17460 ENOG4108ZP8 Acetolactate synthase small subunit CUC43_17535 ENOG4107RVV histidinol phosphate phosphatase, hisj family CUC43_17550 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CUC43_17555 ENOG4105E0M Sulfatase CUC43_17560 ENOG4105VTR Integrase CUC43_17575 ENOG4108IMY Transcriptional regulator CUC43_17585 ENOG4108ZUE Phage regulatory protein rha CUC43_17680 ENOG41085W3 Transposase CUC43_17705 ENOG4105CNU cell division protein FtsK CUC43_17740 ENOG4105CAR Terminase, large subunit CUC43_17755 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CUC43_17820 ENOG4105EKQ RNA-directed DNA polymerase CUC43_17825 ENOG4105C9U ATP-dependent DNA helicase RecQ CUC43_17840 ENOG4105KRN Transcriptional regulator, abrb family CUC43_17845 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CUC43_17850 ENOG4105K70 DNA-binding protein CUC43_17880 ENOG410600T transposase CUC43_17895 ENOG4105W8Z 4'-phosphopantetheinyl transferase CUC43_17980 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CUC43_18000 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CUC43_18005 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CUC43_18015 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CUC43_18020 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CUC43_18025 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CUC43_18035 ENOG4105C8J )-transporter CUC43_18055 ENOG4105DFD Na H antiporter CUC43_18075 ENOG4105ENE Histidine kinase CUC43_18080 ENOG4105WH1 Two component transcriptional regulator luxr family CUC43_18100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CUC43_18150 ENOG4105CJ3 phosphate transporter CUC43_18155 ENOG4107GRR phosphate transport regulator CUC43_18160 ENOG4105BZ4 penicillin-binding protein CUC43_18175 ENOG4105BZU Histidine kinase CUC43_18180 ENOG4105I3N Conserved Protein CUC43_18195 ENOG4105BZU Histidine kinase CUC43_18225 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CUC43_18230 ENOG4105DZ1 carboxypeptidase CUC43_18235 ENOG4108JIC nucleoside recognition domain protein CUC43_18245 ENOG4105FE9 pseudouridine synthase CUC43_18255 ENOG4107TWT Cytochrome c biogenesis protein CUC43_18260 ENOG4105CRE cytochrome C CUC43_18265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_18270 ENOG4105BZU Histidine kinase CUC43_18275 ENOG4108WBT adenosyltransferase CUC43_18280 ENOG41063SB peptidase CUC43_18290 ENOG4108SAX Membrane CUC43_18305 ENOG4105C9U ATP-dependent DNA helicase RecQ CUC43_18310 ENOG4105I7S Abortive infection protein CUC43_18320 ENOG4107RGJ metallophosphoesterase CUC43_18325 ENOG4107X2D transcriptional regulator, merr family CUC43_18330 ENOG4108S6Z Negative regulator of genetic competence CUC43_18355 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CUC43_18360 ENOG4105HDK L-asparaginase CUC43_18395 ENOG4105S2F CUC43_18400 ENOG41065D1 CUC43_18430 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CUC43_18445 ENOG4105XXQ heptaprenyl diphosphate synthase component I CUC43_18455 ENOG4105EAH synthase CUC43_18480 ENOG41068YB TPR repeat-containing protein CUC43_18495 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CUC43_18500 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CUC43_18540 ENOG4108JYZ YitT family CUC43_18550 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CUC43_18570 ENOG4105FJR Lmbe family CUC43_18575 ENOG4105CPK Glycosyl transferase (Group 1 CUC43_18615 ENOG4105DVT helicase CUC43_18620 ENOG4105YAC CUC43_18640 ENOG4105CSM endonuclease III CUC43_18650 ENOG4105BZ4 penicillin-binding protein CUC43_18710 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CUC43_18720 ENOG4105DVT helicase CUC43_18725 ENOG4105CTD carboxy-peptidase CUC43_18735 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CUC43_18740 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CUC43_18745 ENOG4105C2W permease CUC43_18750 ENOG4105DHF Membrane CUC43_18760 ENOG410890F Dynamin family CUC43_18770 ENOG4108W0I acetyltransferase CUC43_18780 ENOG4105KHC sulfurtransferase CUC43_18805 ENOG4106032 Glutathionylspermidine synthase CUC43_18835 ENOG4108SZE gCN5-related N-acetyltransferase CUC43_18855 ENOG41081VK Ribonuclease CUC43_18920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CUC43_18935 ENOG4107RWR Sodium hydrogen exchanger CUC43_18940 ENOG4105CN5 Metallo-Beta-Lactamase CUC43_18945 ENOG4108Z5V transcriptional regulator, merr family CUC43_18955 ENOG4105H67 Protein of unknown function (DUF421) CUC43_18960 ENOG41080C8 DUF218 domain CUC43_19035 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CUC43_19045 ENOG4107R0U MotA TolQ exbB proton channel CUC43_19050 ENOG4106VK6 Flagellar motor protein CUC43_19055 ENOG4107YTP response regulator receiver protein CUC43_19060 ENOG4105CBS Chea signal transduction histidine kinase CUC43_19065 ENOG4105DD5 Flagellar motor switch protein CUC43_19080 ENOG4105BZU Histidine kinase CUC43_19100 ENOG4105E1Q flagellar hook-associated protein CUC43_19105 ENOG4105DTJ flagellar hook-associated protein CUC43_19110 ENOG4107TPX flagellar hook-associated CUC43_19125 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CUC43_19130 ENOG4108ZC9 flagellar basal-body rod protein flgc CUC43_19135 ENOG41075Z6 flagellar hook-basal body complex protein fliE CUC43_19145 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CUC43_19175 ENOG4105BZE flagellar hook protein, FlgE CUC43_19190 ENOG4107R88 Chemotaxis protein (CheV) CUC43_19200 ENOG4105I03 Flagellin CUC43_19205 ENOG4105I03 Flagellin CUC43_19210 ENOG4105E4C Lytic transglycosylase catalytic CUC43_19220 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CUC43_19225 ENOG4105DD5 Flagellar motor switch protein CUC43_19235 ENOG4105CN7 Flagellar biosynthetic protein FliP CUC43_19240 ENOG4105VS8 Flagellar biosynthetic protein fliq CUC43_19250 ENOG4105D00 flagellar biosynthetic protein flhB CUC43_19255 ENOG4105D7B Flagellar biosynthesis protein flha CUC43_19260 ENOG4105FZW flagellar biosynthesis regulator FlhF CUC43_19265 ENOG4105KTQ flagellar basal-body rod protein CUC43_19270 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CUC43_19295 ENOG4108RZE Tetr family transcriptional regulator CUC43_19315 ENOG4105KAC Antibiotic biosynthesis monooxygenase CUC43_19335 ENOG4108U4N (sortase) family CUC43_19365 ENOG4105DUM transcriptional regulator, lysR family CUC43_19375 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CUC43_19380 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component CUC43_19425 ENOG41085W3 Transposase CUC43_19435 ENOG4105CVJ phosphoglycerate mutase CUC43_19450 ENOG4105K56 Transcriptional regulator CUC43_19460 ENOG4105CAQ asparagine synthetase CUC43_19480 ENOG4105PGM cation diffusion facilitator family transporter CUC43_19490 ENOG4105DRR Transcriptional regulator, GntR family CUC43_19495 ENOG4108UZ3 Transporter CUC43_19505 ENOG4105DFD Na H antiporter CUC43_19510 ENOG4105C9Q fumarate hydratase class II CUC43_19530 ENOG4107QJQ Mate efflux family protein CUC43_19540 ENOG4105EC3 peptidase S51, dipeptidase E CUC43_19560 ENOG4107QIV Cytochrome c biogenesis protein CUC43_19585 ENOG4106BRA Membrane CUC43_19625 ENOG4105CJ1 ABC, transporter CUC43_19645 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CUC43_19655 ENOG4108IJ0 Aspartate ammonia-lyase CUC43_19660 ENOG4105C6K Malic enzyme CUC43_19675 ENOG4105C0D helicase CUC43_19725 ENOG4105FVX CUC43_19780 ENOG4105CSR polyphosphate kinase 2 CUC43_19790 ENOG4105DXI Major Facilitator superfamily CUC43_19815 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CUC43_19825 ENOG4105EU0 Major facilitator Superfamily CUC43_19830 ENOG4105C6T cysteine synthase CUC43_19850 ENOG4105C8J )-transporter CUC43_19860 ENOG4105X5K response regulator receiver protein CUC43_19865 ENOG4105H67 Protein of unknown function (DUF421) CUC43_19895 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CUC43_19900 ENOG4105CM2 brancheD-chain amino acid aminotransferase CUC43_19905 ENOG4105C7K acetolactate synthase CUC43_19915 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CUC43_19925 ENOG4105C7B Threonine dehydratase CUC43_19955 ENOG4105C6X Major Facilitator CUC43_19960 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CUC43_19970 ENOG4105DY9 regulatoR CUC43_19975 ENOG4105CYC Transferase CUC43_19995 ENOG4108IBT Inherit from COG: transposase CUC43_20040 ENOG41068WN CUC43_20060 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CUC43_20065 ENOG4105C72 UPF0176 protein CUC43_20080 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CUC43_20085 ENOG4105C0X amino acid CUC43_20115 ENOG410829K Lysine exporter protein (Lyse ygga) CUC43_20130 ENOG4107RHR regulatoR CUC43_20140 ENOG4105D9N nucleoside CUC43_20145 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CUC43_20170 ENOG4107RAQ aminopeptidase CUC43_20225 ENOG4108T5E Copper resistance protein CUC43_20230 ENOG4105KTB nuclear export factor GLE1 CUC43_20240 ENOG4107RT3 EamA-like transporter family CUC43_20245 ENOG4105GZI Transcriptional regulator CUC43_20250 ENOG4108Z40 Transcriptional regulator CUC43_20255 ENOG4107ZXU DSBA oxidoreductase CUC43_20260 ENOG4108TVJ Nitroreductase CUC43_20270 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CUC43_20275 ENOG4106F5Q Membrane CUC43_20280 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CUC43_20310 ENOG4105KVH Transcriptional regulator CUC43_20315 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CUC43_20325 ENOG4105KNA -acetyltransferase CUC43_20335 ENOG4105CHR reductase CUC43_20345 ENOG4105JAB phenazine biosynthesis protein, phzf family CUC43_20385 ENOG4105KVH Transcriptional regulator CUC43_20390 ENOG4105KVH Transcriptional regulator CUC43_20395 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CUC43_20400 ENOG4105D9R oxidoreductase CUC43_20405 ENOG4108TZY GntR Family Transcriptional Regulator CUC43_20410 ENOG4105KVH Transcriptional regulator CUC43_20455 ENOG41085W3 Transposase CUC43_20485 ENOG4106WTF Glycosyl transferase, family 2 CUC43_20520 ENOG4105C44 Serine transporter CUC43_20525 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CUC43_20530 ENOG41090KN UPF0303 protein CUC43_20540 ENOG4105F27 Major Facilitator CUC43_20545 ENOG4105CV8 reductase CUC43_20565 ENOG4105KVH Transcriptional regulator CUC43_20570 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CUC43_20575 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CUC43_20580 ENOG4108UX3 '-nucleotidase CUC43_20585 ENOG4105C8Q Methyl-accepting chemotaxis CUC43_20600 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CUC43_20620 ENOG4105PDP Short chain dehydrogenase CUC43_20630 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CUC43_20635 ENOG4105CIS alcohol dehydrogenase CUC43_20640 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CUC43_20645 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CUC43_20660 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CUC43_20665 ENOG4105C6Z Gluconate CUC43_20675 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CUC43_20680 ENOG4105XDF Protein of unknown function (DUF1272) CUC43_20685 ENOG4105DDN Pentapeptide repeat-containing protein CUC43_20715 ENOG4105FAW cDP-glucose 4,6-dehydratase CUC43_20720 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CUC43_20735 ENOG4105C37 (CBS) domain CUC43_20760 ENOG4105EV4 Multidrug resistance protein mdtH CUC43_20770 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CUC43_20810 ENOG4105C31 Tryptophanyl-tRNA synthetase CUC43_20815 ENOG4108UW5 maltose o-acetyltransferase CUC43_20820 ENOG4105DKQ ROK family CUC43_20825 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CUC43_20885 ENOG4105CJ1 ABC, transporter CUC43_20895 ENOG4108PSK reductase CUC43_20920 ENOG4108RCM Nitroreductase CUC43_20925 ENOG4105KVH Transcriptional regulator CUC43_20945 ENOG4108Z66 YbaK ebsC protein CUC43_20980 ENOG4108K8S endonuclease I CUC43_21005 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CUC43_21040 ENOG4105DYS nad(p)h dehydrogenase (quinone) CUC43_21050 ENOG4105CRW Short chain fatty acid transporter CUC43_21065 ENOG4107AUC CUC43_21070 ENOG4105KBX Transcriptional regulator, TetR family CUC43_21075 ENOG4105KPY Small multidrug resistance protein CUC43_21080 ENOG4105RXJ CUC43_21095 ENOG4105DA5 (ABC) transporter CUC43_21115 ENOG4105CZM Major Facilitator CUC43_21120 ENOG4107MII Sugar-specific transcriptional regulator TrmB CUC43_21135 ENOG4108ISG Major Facilitator CUC43_21145 ENOG4105PNM synthesis protein CUC43_21150 ENOG4108VXD carboxy-peptidase CUC43_21185 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CUC43_21200 ENOG410874W AraC family transcriptional regulator CUC43_21210 ENOG41082W1 Cupin 2, conserved barrel domain protein CUC43_21230 ENOG4108JQ1 Dehydrogenase CUC43_21250 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CUC43_21270 ENOG4106P55 Transcriptional regulator CUC43_21280 ENOG4107QR9 Iron-sulfur cluster binding protein CUC43_21285 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) CUC43_21290 ENOG4105DJB Major Facilitator Superfamily CUC43_21295 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CUC43_21305 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CUC43_21310 ENOG4108U05 Transcriptional regulator CUC43_21325 ENOG4105BZU Histidine kinase CUC43_21345 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CUC43_21365 ENOG4105JQZ Methyltransferase CUC43_21370 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CUC43_21380 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CUC43_21385 ENOG4108NNI Beta-lactamase domain-containing protein CUC43_21410 ENOG4105K6H D-cysteine desulfhydrase CUC43_21445 ENOG4108NIW Leucine export protein LeuE CUC43_21490 ENOG4105C0R drug resistance transporter emrb qaca subfamily CUC43_21495 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CUC43_21560 ENOG4108YXU transcriptional regulator AsnC family CUC43_21565 ENOG4105CHR reductase CUC43_21570 ENOG4105M4P Tetr family transcriptional regulator CUC43_21575 ENOG4105F27 Major Facilitator CUC43_21580 ENOG4108IG5 Transcriptional regulator CUC43_21585 ENOG4107P5I polyketide synthase CUC43_21605 ENOG4105NAE bifunctional deaminase-reductase domain protein CUC43_21620 ENOG41085FC arsR family transcriptional regulator CUC43_21625 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CUC43_21630 ENOG4105D6J arsenicaL-resistance protein CUC43_21655 ENOG4108NEV two component transcriptional regulator, LytTR family CUC43_21670 ENOG4105C19 ABC transporter CUC43_21715 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CUC43_21735 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CUC43_21740 ENOG4108TWJ NADH dehydrogenase subunit 5 CUC43_21755 ENOG4105CVP deoxyribo-dipyrimidine photolyase CUC43_21795 ENOG4105DWP Membrane CUC43_21800 ENOG4105DUM transcriptional regulator, lysR family CUC43_21850 ENOG4107QTZ amino acid CUC43_21860 ENOG4107QJQ Mate efflux family protein CUC43_21880 ENOG4106A3M Cytochrome p-450 CUC43_21895 ENOG4105CSV Glutaminase CUC43_21920 ENOG4108Q8B Spore germination protein CUC43_21925 ENOG4108NHD germination protein CUC43_21930 ENOG4105II7 pyrroline-5-carboxylate reductase CUC43_21935 ENOG4105CUB amino acid CUC43_21940 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CUC43_21950 ENOG4108IMY Transcriptional regulator CUC43_21955 ENOG4105HDK L-asparaginase CUC43_21960 ENOG4108IJ0 Aspartate ammonia-lyase CUC43_21970 ENOG4105E2A Dehydrogenase CUC43_22000 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CUC43_22035 ENOG4105DWD nucleoside recognition domain protein CUC43_22050 ENOG4105FDT acyl-CoA dehydrogenase CUC43_22060 ENOG4108ZHR arsR family transcriptional regulator CUC43_22065 ENOG4108ZRV stage ii sporulation protein p CUC43_22070 ENOG4106N3A copper homeostasis protein cutc CUC43_22080 ENOG4107258 Transcriptional regulator CUC43_22085 ENOG4105P4J Allophanate hydrolase, subunit 1 CUC43_22120 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CUC43_22130 ENOG4107RF6 penicillin-binding protein CUC43_22165 ENOG4105F1N DNA alkylation repair CUC43_22175 ENOG4108IQI permease CUC43_22185 ENOG410635A Membrane CUC43_22230 ENOG4108PCN EamA-like transporter family CUC43_22245 ENOG4108XET gCN5-related N-acetyltransferase CUC43_22250 ENOG4108DMH HTH_ARAC CUC43_22275 ENOG4105C19 ABC transporter CUC43_22280 ENOG4105CMR udp-glucose 4-epimerase CUC43_22285 ENOG4105WEC Molybdate metabolism regulator CUC43_22290 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CUC43_22310 ENOG4105FS7 Transcriptional regulator CUC43_22315 ENOG4108TVJ Nitroreductase CUC43_22325 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CUC43_22365 ENOG4105C8Y Acetylornithine aminotransferase CUC43_22385 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CUC43_22425 ENOG4108WCX response regulator CUC43_22435 ENOG41090T1 Membrane CUC43_22450 ENOG4105VMP Transcriptional regulator CUC43_22460 ENOG4105G6Z alkaline phosphatase CUC43_22470 ENOG4105ECK Fatty Acid Desaturase CUC43_22475 ENOG4105E0Y RtcB Protein CUC43_22495 ENOG4107258 Transcriptional regulator CUC43_22505 ENOG4105II7 pyrroline-5-carboxylate reductase CUC43_22545 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CUC43_22555 ENOG41085W3 Transposase CUC43_22580 ENOG41061GT Aldolase CUC43_22590 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CUC43_22595 ENOG4105DKT Transcriptional regulator CUC43_22605 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CUC43_22615 ENOG4105D4B ABC, transporter CUC43_22640 ENOG41069ER domain protein CUC43_22675 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CUC43_22710 ENOG41082JN Transcriptional regulator CUC43_22715 ENOG4105EYF MMPL domain protein CUC43_22725 ENOG4105C5H ABC transporter CUC43_22735 ENOG4105E0M Sulfatase CUC43_22740 ENOG4108ZCF integral membrane protein CUC43_22745 ENOG4106ETB IIa component CUC43_22755 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC CUC43_22765 ENOG4107VMI polysaccharide deacetylase CUC43_22820 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CUC43_22865 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CUC43_22870 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CUC43_22875 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CUC43_22890 ENOG4105C02 permease CUC43_22945 ENOG4105DVE abc transporter atp-binding protein CUC43_22975 ENOG4105CHM Aminotransferase CUC43_23030 ENOG4107BMA Transglycosylase associated protein CUC43_23050 ENOG4106K7D Major facilitator family transporter CUC43_23055 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CUC43_23120 ENOG4105EPR degv family CUC43_23130 ENOG4105DPN Oligoendopeptidase f CUC43_23165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_23170 ENOG4105BZU Histidine kinase CUC43_23175 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CUC43_23225 ENOG4105DTQ mandelate racemase muconate lactonizing CUC43_23255 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CUC43_23270 ENOG4107T5V SNARE associated Golgi CUC43_23315 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CUC43_23325 ENOG41080HI glycine oxidase CUC43_23330 ENOG4105CTU Proline racemase CUC43_23335 ENOG4105CTU Proline racemase CUC43_23340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CUC43_23345 ENOG4105C26 Dehydrogenase CUC43_23350 ENOG4105BZG amino acid carrier protein CUC43_23370 ENOG4108M1A Chitin-binding protein CUC43_23425 ENOG4105C9U ATP-dependent DNA helicase RecQ CUC43_23445 ENOG4105EEM helicase CUC43_23465 ENOG4108Z7F N-acetyltransferase CUC43_23490 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CUC43_23500 ENOG4105MSB protein, conserved in bacteria CUC43_23505 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CUC43_23525 ENOG41087PP glycosyltransferase MGT family CUC43_23530 ENOG4108M1A Chitin-binding protein CUC43_23535 ENOG41082BV acetyltransferase CUC43_23565 ENOG4108IJ7 Glycine betaine CUC43_23570 ENOG4107SQ8 Glycine betaine CUC43_23610 ENOG4105DBI uridine monophosphokinase CUC43_23615 ENOG4105RHY Pfam:UPF0157 CUC43_23620 ENOG4105E1F short-chain dehydrogenase reductase CUC43_23630 ENOG4107RUY (E1 component), alpha subunit CUC43_23640 ENOG4107QKR Dehydrogenase CUC43_23660 ENOG41062ES Transcriptional regulator CUC43_23675 ENOG4105E98 transcriptional regulator DeoR family CUC43_23695 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CUC43_23720 ENOG4105DTQ mandelate racemase muconate lactonizing CUC43_23725 ENOG4108K88 Membrane CUC43_23735 ENOG4107Z3H Transcriptional regulator, TetR family CUC43_23775 ENOG4105MSI germination protein ypeb CUC43_23825 ENOG4105CIS alcohol dehydrogenase CUC43_23835 ENOG4105FDR Membrane CUC43_23845 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CUC43_23850 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CUC43_23880 ENOG4108IUM Glycogen debranching enzyme CUC43_23905 ENOG4105U0R haloacid dehalogenase-like hydrolase CUC43_23930 ENOG4107VFR oxidoreductase CUC43_23965 ENOG4105PKS Excinuclease abc c subunit domain protein CUC43_24000 ENOG4105KWG Pfam:DUF1696 CUC43_24005 ENOG4108NRW Phospholipase, patatin family CUC43_24025 ENOG4108XI2 Domain of unknown function (DUF1963) CUC43_24055 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CUC43_24075 ENOG4105FCD Major Facilitator CUC43_24100 ENOG4105EGD dinuclear metal center protein, YbgI family CUC43_24110 ENOG4107Y9U Membrane CUC43_24130 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CUC43_24160 ENOG41085W3 Transposase CUC43_24200 ENOG4105CJN penicillin-binding protein CUC43_24205 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CUC43_24210 ENOG4105CB2 alcohol dehydrogenase CUC43_24215 ENOG4105GR3 Histidine kinase CUC43_24220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_24240 ENOG4108HGU Histidine kinase CUC43_24305 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CUC43_24400 ENOG41076HS cation diffusion facilitator family transporter CUC43_24425 ENOG41085W3 Transposase CUC43_24455 ENOG4105BZU Histidine kinase CUC43_24465 ENOG410667J hydrolase CUC43_24560 ENOG4105ETU transcriptional activator (TenA CUC43_24575 ENOG4105D6E homoserine dehydrogenase CUC43_24650 ENOG4105DK7 lysyl-tRNA synthetase CUC43_24660 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CUC43_24670 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CUC43_24680 ENOG410900G Protein of unknown function (DUF421) CUC43_24705 ENOG4105EFA 4-hydroxyphenylacetate CUC43_24735 ENOG4105CUV Homoserine Kinase CUC43_24755 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CUC43_24770 ENOG41089UC methyltransferase, type 11 CUC43_24780 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CUC43_24795 ENOG4105FQP Beta-lactamase CUC43_24810 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CUC43_24845 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CUC43_24860 ENOG4105T9C HD domain CUC43_24890 ENOG4105DBI uridine monophosphokinase CUC43_24905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CUC43_24910 ENOG4107QX3 carboxylase CUC43_24915 ENOG4105E39 Enoyl-CoA hydratase CUC43_24920 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CUC43_24925 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CUC43_24930 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CUC43_24935 ENOG4105C1G acyl-Coa dehydrogenase CUC43_24955 ENOG4107Z3H Transcriptional regulator, TetR family CUC43_24965 ENOG4105CJ1 ABC, transporter CUC43_25000 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CUC43_25005 ENOG41090R9 glycosyltransferase CUC43_25010 ENOG4105C1B dTDP-glucose 4-6-dehydratase CUC43_25015 ENOG4105FAW cDP-glucose 4,6-dehydratase CUC43_25060 ENOG4105BZU Histidine kinase CUC43_25115 ENOG4105EXC Acyl-transferase CUC43_25145 ENOG4105DH8 myo-inositol catabolism CUC43_25150 ENOG4105D2N Aldolase CUC43_25175 ENOG4105CK5 oxidoreductase CUC43_25185 ENOG4105IE8 Alpha-ketoglutarate permease CUC43_25190 ENOG4105ETE Transcriptional regulator (LacI family CUC43_25195 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CUC43_25205 ENOG4107RF6 penicillin-binding protein CUC43_25210 ENOG4107RF6 penicillin-binding protein CUC43_25265 ENOG4105CIN aminoacyl-histidine dipeptidase CUC43_25295 ENOG4105K56 Transcriptional regulator CUC43_25300 ENOG4107RA9 decarboxylase CUC43_25310 ENOG41088CC tellurite resistance protein tehB CUC43_25315 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CUC43_25330 ENOG4108RZE Tetr family transcriptional regulator CUC43_25345 ENOG4105C1J atp-dependent rna helicase CUC43_25360 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CUC43_25385 ENOG4108INS Transcriptional regulator CUC43_25405 ENOG4105RD7 BadF BadG BcrA BcrD CUC43_25430 ENOG4105F32 YngK protein CUC43_25460 ENOG4108KPJ rna polymerase sigma factor CUC43_25475 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CUC43_25505 ENOG4108JCI Transcriptional regulator CUC43_25525 ENOG4105BZ1 (ABC) transporter CUC43_25530 ENOG4105BZ1 (ABC) transporter CUC43_25565 ENOG4107V2S Transcriptional regulator CUC43_25575 ENOG41085W3 Transposase CUC43_25790 ENOG4108C33 Resolvase CUC43_25830 ENOG4105KRN Transcriptional regulator, abrb family CUC43_25880 ENOG41085W3 Transposase CUC43_25920 ENOG4105C2M dna polymerase I CUC43_26030 ENOG4105VEQ Cold shock protein CUC43_26040 ENOG41068WN CUC43_26050 ENOG4105C1Q protoporphyrinogen oxidase CUC43_26080 ENOG4105WCN acetyltransferase CUC43_26105 ENOG4105EYF MMPL domain protein CUC43_26115 ENOG4105C5X domain protein CUC43_26125 ENOG4107MII Sugar-specific transcriptional regulator TrmB CUC43_26140 ENOG41081I9 integral membrane protein CUC43_26190 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CUC43_26205 ENOG4105C19 ABC transporter CUC43_26215 ENOG4105C22 threonyL-tRNA synthetase CUC43_26220 ENOG4105FE9 pseudouridine synthase CUC43_26245 ENOG4105BZG amino acid carrier protein CUC43_26265 ENOG4105K70 DNA-binding protein CUC43_26280 ENOG4105C0R drug resistance transporter emrb qaca subfamily CUC43_26285 ENOG4105WQT MbtH domain protein CUC43_26290 ENOG4105CEY Amp-dependent synthetase and ligase CUC43_26295 ENOG4105WQI isochorismatase CUC43_26300 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CUC43_26305 ENOG4105E4F Isochorismate synthase CUC43_26310 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CUC43_26315 ENOG4105FCD Major Facilitator CUC43_26345 ENOG4107RFY SbcCD D subunit CUC43_26360 ENOG4105E39 Enoyl-CoA hydratase CUC43_26365 ENOG4105N14 lysine exporter protein LysE YggA CUC43_26375 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CUC43_26380 ENOG4105C1G acyl-Coa dehydrogenase CUC43_26385 ENOG4105CR4 methylisocitrate lyase CUC43_26390 ENOG4105DXD 2-methylcitrate dehydratase CUC43_26400 ENOG4105W8X HesB YadR YfhF-family protein CUC43_26405 ENOG4105CZM Major Facilitator CUC43_26415 ENOG4105BZ4 penicillin-binding protein CUC43_26435 ENOG4105CHR reductase CUC43_26470 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CUC43_26505 ENOG4108AEY RNA polymerase sigma factor CUC43_26540 ENOG4105SZ6 Thioredoxin CUC43_26550 ENOG410841Q phosphoesterase PA-phosphatase related protein CUC43_26595 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CUC43_26600 ENOG4108JUB Transcriptional regulator CUC43_26605 ENOG4108TSC N-acetyltransferase CUC43_26610 ENOG4107S4Y M20 DapE family protein YgeY CUC43_26625 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CUC43_26655 ENOG4105C37 (CBS) domain CUC43_26690 ENOG4105E90 ABC transporter CUC43_26695 ENOG4108IJ8 ABC transporter CUC43_26755 ENOG4106KNT transcriptional regulator CUC43_26765 ENOG4105WH1 Two component transcriptional regulator luxr family CUC43_26770 ENOG4105BZU Histidine kinase CUC43_26775 ENOG4105D8X mechanosensitive ion channel CUC43_26780 ENOG4107Y70 Heat shock protein CUC43_26805 ENOG4105F0I Aminotransferase CUC43_26810 ENOG4108MES Periplasmic binding protein CUC43_26825 ENOG4105CAQ asparagine synthetase CUC43_26830 ENOG4107Y70 Heat shock protein CUC43_26835 ENOG4108KF3 Electron transport protein SCO1 SenC CUC43_26840 ENOG4105E8R UPF0173 metal-dependent hydrolase CUC43_26845 ENOG4108RCR degv family CUC43_26860 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CUC43_26870 ENOG4108UT2 hemolysin iii CUC43_26875 ENOG4105E9Q Acyl-transferase CUC43_26885 ENOG4107RVG penicillin-binding protein CUC43_26925 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 CUC43_26950 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CUC43_26955 ENOG4105KD7 acetyltransferase CUC43_26995 ENOG4105CY2 Citrate transporter CUC43_27000 ENOG4107XGZ Hydrolase CUC43_27020 ENOG4105C8J )-transporter CUC43_27145 ENOG4105EC2 ftsk spoIIIe CUC43_27165 ENOG4105C5S asparaginyl-tRNA synthetase CUC43_27225 ENOG4105C75 arginyL-tRNA synthetase CUC43_27230 ENOG4107YX5 Pfam:DUF548 CUC43_27255 ENOG4105EKQ RNA-directed DNA polymerase CUC43_27270 ENOG4105C5H ABC transporter CUC43_27305 ENOG4105CDU Replicative dna helicase CUC43_27315 ENOG4105MCT stage V sporulation protein S CUC43_27345 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CUC43_27350 ENOG4108IFG nitrite reductase, (NAD(P)H) CUC43_27355 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CUC43_27360 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CUC43_27365 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CUC43_27370 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CUC43_27405 ENOG4108ZAF Molybdopterin CUC43_27410 ENOG4105CVM Molybdenum cofactor synthesis domain protein CUC43_27415 ENOG4105D06 uba thif-type nad fad binding protein CUC43_27420 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CUC43_27425 ENOG4107V6Q Cyclic nucleotide-binding domain CUC43_27435 ENOG4105R3A Nitrate reductase CUC43_27440 ENOG4108IUE nitrate reductase beta subunit CUC43_27450 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CUC43_27465 ENOG4108V06 Glutathione peroxidase CUC43_27475 ENOG4105CNW domain protein CUC43_27500 ENOG4105EMN RNA polymerase sigma factor CUC43_27505 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CUC43_27515 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase CUC43_27535 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CUC43_27560 ENOG4105KBJ sporulation protein ytfj CUC43_27610 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CUC43_27640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CUC43_27645 ENOG4108JYZ YitT family CUC43_27650 ENOG41087PP glycosyltransferase MGT family CUC43_27665 ENOG4107RBS Methyltransferase CUC43_27670 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CUC43_27680 ENOG4108X4Q Hydrolase CUC43_27720 ENOG4105KME endoribonuclease L-psp CUC43_27735 ENOG4105U1N riboflavin CUC43_27745 ENOG4105EFA 4-hydroxyphenylacetate CUC43_27765 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CUC43_27775 ENOG4108VXD carboxy-peptidase CUC43_27785 ENOG4108ZRV stage ii sporulation protein p CUC43_27805 ENOG4108Z7R Chaperone CsaA CUC43_27825 ENOG4105C37 (CBS) domain CUC43_27830 ENOG4105SXS Protein of unknown function (DUF456) CUC43_27850 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CUC43_27860 ENOG4108S4H thioesterase Superfamily protein CUC43_27870 ENOG4108PJD permease CUC43_27885 ENOG4107T5V SNARE associated Golgi CUC43_27915 ENOG4105CVJ phosphoglycerate mutase CUC43_27940 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CUC43_27950 ENOG4105K4T epimerase CUC43_27960 ENOG4105DSE periplasmic solute binding protein CUC43_27970 ENOG4105CKI cobalamin synthesis protein CUC43_27975 ENOG4107QM2 Aldo Keto reductase CUC43_27980 ENOG4105VMI -acetyltransferase CUC43_27995 ENOG4105DEN Luciferase family CUC43_28010 ENOG4108WPJ Ferritin-like domain CUC43_28015 ENOG4108K88 Membrane CUC43_28060 ENOG4107XZQ multidrug resistance protein CUC43_28065 ENOG4105CPC Aldo Keto reductase CUC43_28070 ENOG4105YVS arsR family transcriptional regulator CUC43_28075 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase CUC43_28085 ENOG4105KRN Transcriptional regulator, abrb family CUC43_28135 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CUC43_28140 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CUC43_28150 ENOG4105YWU small acid-soluble spore protein CUC43_28155 ENOG4108WBH protein TIM barrel CUC43_28170 ENOG4105CEY Amp-dependent synthetase and ligase CUC43_28175 ENOG4105DUU IucA IucC family protein CUC43_28185 ENOG4105VRR gCN5-related N-acetyltransferase CUC43_28190 ENOG4105KT7 mgtC SapB transporter CUC43_28200 ENOG4107VMI polysaccharide deacetylase CUC43_28205 ENOG4105BZU Histidine kinase CUC43_28210 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CUC43_28220 ENOG4108KGH TRANSCRIPTIONal CUC43_28245 ENOG4105D6E homoserine dehydrogenase CUC43_28260 ENOG4108ZJ4 polysaccharide deacetylase CUC43_28265 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CUC43_28270 ENOG4108VQJ O-methyltransferase CUC43_28285 ENOG4105BZU Histidine kinase CUC43_28290 ENOG4105EFI regulatoR CUC43_28295 ENOG4105BZ1 (ABC) transporter CUC43_28340 ENOG4108UT6 Transferase hexapeptide repeat containing protein CUC43_28350 ENOG4105K64 Glycosyl transferase, family 2 CUC43_28360 ENOG4108JJ8 (ABC) transporter CUC43_28365 ENOG4108JJ9 ABC, transporter CUC43_28370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CUC43_28375 ENOG4105C4M (Ubiquinol oxidase) subunit I CUC43_28395 ENOG4105MDS 4-oxalocrotonate tautomerase CUC43_28405 ENOG4105SKE transcriptional Regulator LysR family CUC43_28415 ENOG4105C32 Amino acid ABC transporter (Permease) CUC43_28420 ENOG4108IV0 ABC, transporter CUC43_28425 ENOG4105C0Z ABC transporter CUC43_28435 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CUC43_28440 ENOG4108Z7G MaoC domain protein dehydratase CUC43_28475 ENOG4108ZJ4 polysaccharide deacetylase CUC43_28515 ENOG4105KAF membrAne CUC43_28545 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CUC43_28600 ENOG4105H3G oxidoreductase CUC43_28670 ENOG4108TN2 lmbE family CUC43_28680 ENOG4107R3E Citrate transporter CUC43_28695 ENOG4108MES Periplasmic binding protein CUC43_28700 ENOG4105EHG Permease protein CUC43_28705 ENOG4105DQ5 transport system permease protein CUC43_28710 ENOG4105NX3 Membrane CUC43_28735 ENOG4107CUJ Protein of unknown function (DUF2690) CUC43_28745 ENOG4107V2S Transcriptional regulator CUC43_28765 ENOG4105C98 muts2 protein CUC43_28775 ENOG4105E5K Alpha-amylase CUC43_28780 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CUC43_28785 ENOG4105DPN Oligoendopeptidase f CUC43_28805 ENOG4108A04 Beta-lactamase CUC43_28835 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CUC43_28890 ENOG41082BM Transcriptional regulator, arsr family CUC43_28895 ENOG4105CIS alcohol dehydrogenase CUC43_28905 ENOG4107JM4 Tetratricopeptide repeat CUC43_28920 ENOG4105RHY Pfam:UPF0157 CUC43_28930 ENOG4105C09 Bile acid CUC43_28935 ENOG4105CQB FAD linked oxidase domain protein CUC43_28960 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CUC43_28980 ENOG41067SE Tetr family transcriptional regulator CUC43_28985 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity CUC43_29010 ENOG4105BZU Histidine kinase CUC43_29020 ENOG4105KT7 mgtC SapB transporter CUC43_29035 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CUC43_29040 ENOG4105EAB amino acid AbC transporter CUC43_29065 ENOG41073R8 VanW family CUC43_29075 ENOG4108R1P CUC43_29095 ENOG4105VEQ Cold shock protein CUC43_29115 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CUC43_29135 ENOG410904N short-chain dehydrogenase reductase CUC43_29145 ENOG4106IQC argininosuccinate lyase CUC43_29160 ENOG4108IA2 Sodium pantothenate symporter CUC43_29170 ENOG4105C26 Dehydrogenase CUC43_29175 ENOG4105CHR reductase CUC43_29185 ENOG4105EWU Squalene--hopene cyclase CUC43_29195 ENOG4105FR1 rard protein CUC43_29200 ENOG410696E Membrane CUC43_29215 ENOG4105D1F ATP-binding protein CUC43_29225 ENOG4108ZAF Molybdopterin CUC43_29230 ENOG4105CVM Molybdenum cofactor synthesis domain protein CUC43_29235 ENOG4105D06 uba thif-type nad fad binding protein CUC43_29240 ENOG4105TMB Formate nitrite transporter CUC43_29270 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CUC43_29405 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CUC43_29415 ENOG4105CAR Terminase, large subunit CUC43_29450 ENOG4105CNU cell division protein FtsK CUC43_29475 ENOG41085W3 Transposase CUC43_29565 ENOG4108JB9 formate dehydrogenase CUC43_29575 ENOG4105E1K spore germination protein CUC43_29645 ENOG4108KGH TRANSCRIPTIONal CUC43_29655 ENOG4105EMN RNA polymerase sigma factor CUC43_29675 ENOG4105CIG ABC transporter CUC43_29695 ENOG4105D9R oxidoreductase CUC43_29705 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CUC43_29715 ENOG4105K4P CoA-binding domain protein CUC43_29720 ENOG4105C0H protease CUC43_29725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_29735 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CUC43_29745 ENOG4105W8X HesB YadR YfhF-family protein CUC43_29770 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CUC43_29775 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CUC43_29785 ENOG4108JJA ABC, transporter CUC43_29790 ENOG4108I0Z Aconitate hydratase CUC43_29820 ENOG4105E5W Transporter CUC43_29835 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CUC43_29855 ENOG4107F3J Amp-dependent synthetase and ligase CUC43_29860 ENOG4107ZYJ bioY protein CUC43_29865 ENOG4105CEY Amp-dependent synthetase and ligase CUC43_29875 ENOG4105CJ1 ABC, transporter CUC43_29880 ENOG4108IMY Transcriptional regulator CUC43_29935 ENOG4107AYK membrAne CUC43_29950 ENOG4105BZU Histidine kinase CUC43_29955 ENOG4105FBA Phospholipase Carboxylesterase CUC43_29960 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CUC43_29965 ENOG4105CK7 Sodium proline symporter CUC43_29975 ENOG4105CBC glutamate synthase CUC43_29980 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CUC43_30000 ENOG4108903 Formimidoylglutamase CUC43_30010 ENOG4105CGP Urocanate hydratase CUC43_30060 ENOG4107QIV Cytochrome c biogenesis protein CUC43_30075 ENOG4105CH2 amidohydrolase CUC43_30085 ENOG4105CJ1 ABC, transporter CUC43_30095 ENOG4107RSM transcriptional regulator CUC43_30105 ENOG41067MG lrgb family CUC43_30130 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CUC43_30150 ENOG4105BZ1 (ABC) transporter CUC43_30155 ENOG4105BZ1 (ABC) transporter CUC43_30190 ENOG4108HW3 (ABC) transporter CUC43_30195 ENOG4105CGH 5'-nucleotidase CUC43_30205 ENOG4108SVB resolvase CUC43_30225 ENOG4105K7K Transcriptional regulator CUC43_30230 ENOG4105BZ1 (ABC) transporter CUC43_30260 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CUC43_30265 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family CUC43_30270 ENOG4105D3Q Sugar transferase CUC43_30300 ENOG4105CGN Glycosyl transferase (Group 1 CUC43_30315 ENOG4105X1N Glycosyl transferase family 8 CUC43_30325 ENOG41068W6 Capsular polysaccharide biosynthesis protein CUC43_30330 ENOG4107SJB teichoic acid biosynthesis CUC43_30335 ENOG4108KMV Glycosyl transferase (Group 1 CUC43_30340 ENOG4108PQP glycosyl transferase group 1 CUC43_30350 ENOG4107YJ4 chain length determinant protein CUC43_30355 ENOG4105HTX biosynthesis protein CUC43_30360 ENOG4105C5F glutamine synthetase CUC43_30365 ENOG4105KV4 Transcriptional regulator CUC43_30370 ENOG4105CXI aluminum resistance protein CUC43_30375 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CUC43_30380 ENOG4105EN6 Membrane CUC43_30385 ENOG4106F1P AAA ATPase, central domain protein CUC43_30415 ENOG41069ER domain protein CUC43_30425 ENOG4105DM4 PTS System CUC43_30430 ENOG4105DE4 1-phosphofructokinase CUC43_30435 ENOG4105E98 transcriptional regulator DeoR family CUC43_30440 ENOG4107QW4 alcohol dehydrogenase CUC43_30445 ENOG4108SJC Membrane CUC43_30460 ENOG4105C85 amino acid CUC43_30480 ENOG4105TMB Formate nitrite transporter CUC43_30485 ENOG4105K70 DNA-binding protein CUC43_30495 ENOG4105C59 p-type ATPase CUC43_30500 ENOG410681U heavy metal transport detoxification protein CUC43_30505 ENOG4105VPX protein, conserved in bacteria CUC43_30515 ENOG4105NIV Esterase CUC43_30520 ENOG4105E0A ABC, transporter CUC43_30540 ENOG4105CGK Exodeoxyribonuclease III CUC43_30550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CUC43_30555 ENOG4105D03 DNA-3-methyladenine glycosylase II CUC43_30585 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CUC43_30605 ENOG4107ZY0 Phenazine biosynthesis-like protein CUC43_30615 ENOG41067MG lrgb family CUC43_30630 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CUC43_30635 ENOG4107YEI lmbE family CUC43_30645 ENOG4108S3Y transcriptional regulator CUC43_30650 ENOG4105CS2 ec 3.2.1.21 CUC43_30665 ENOG4105F0V Cell wall hydrolase CUC43_30685 ENOG410890F Dynamin family CUC43_30700 ENOG4107QHE Choloylglycine hydrolase CUC43_30725 ENOG4105DA5 (ABC) transporter CUC43_30755 ENOG4105DQU oxidoreductase, subunit beta CUC43_30760 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CUC43_30765 ENOG4108IGT Dipeptidase CUC43_30770 ENOG4105MCT stage V sporulation protein S CUC43_30775 ENOG4105D48 metallophosphoesterase CUC43_30805 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CUC43_30820 ENOG4105XZV Protein of unknown function (DUF3243) CUC43_30825 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CUC43_30850 ENOG4105UIB (ABC) transporter CUC43_30855 ENOG4108JQ9 ABC transporter CUC43_30860 ENOG4105DIH basic membrane CUC43_30865 ENOG4105FDP GntR family transcriptional regulator CUC43_30875 ENOG4107QZI cell division protein FtsK CUC43_30885 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CUC43_30900 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CUC43_30910 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CUC43_30915 ENOG4108S0H Dipicolinic acid synthetase, b subunit CUC43_30920 ENOG4105E35 Dipicolinate synthase subunit A CUC43_30930 ENOG4105C1V Peptidase, M16 CUC43_30950 ENOG4105DTN riboflavin biosynthesis protein ribF CUC43_30965 ENOG4105W7A Protein of unknown function (DUF503) CUC43_30975 ENOG4105VHM ribosomal protein CUC43_30980 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CUC43_30985 ENOG4105CHV Transcription elongation factor NusA CUC43_30995 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CUC43_31010 ENOG4105DZP Membrane-associated zinc metalloprotease CUC43_31020 ENOG4105KNE Phosphatidate cytidylyltransferase CUC43_31065 ENOG4108HE4 integrase family CUC43_31075 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CUC43_31095 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CUC43_31110 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CUC43_31135 ENOG4105VB6 UPF0109 protein CUC43_31155 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CUC43_31160 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CUC43_31175 ENOG4105CHR reductase CUC43_31180 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CUC43_31195 ENOG4105CB5 ATP-dependent DNA helicase recG CUC43_31200 ENOG4105DP4 dak2 domain fusion protein ylov CUC43_31205 ENOG4108ZAA Alkaline-shock protein CUC43_31220 ENOG4105FJ0 thiamine CUC43_31225 ENOG4105DJV ribulose-phosphate 3-epimerase CUC43_31235 ENOG4105D9P serine threonine protein kinase CUC43_31240 ENOG4108ZF3 Phosphatase CUC43_31245 ENOG4105D13 transposase CUC43_31250 ENOG4105D13 transposase CUC43_31355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CUC43_31380 ENOG4105BZU Histidine kinase CUC43_31505 ENOG4105D29 Helix-turn-helix type 11 domain protein CUC43_31550 ENOG4105BZU Histidine kinase CUC43_31795 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CUC43_31895 ENOG4107RBB ABC transporter, permease CUC43_31900 ENOG4105C19 ABC transporter CUC43_31930 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) CUC43_31975 ENOG4105KRN Transcriptional regulator, abrb family CUC43_32135 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CUC43_32140 ENOG410880H cysteine synthase CUC43_32145 ENOG4105C87 Aminotransferase class I and II CUC43_32150 ENOG4107Y9U Membrane CUC43_32195 ENOG4105CNA YD repeat protein CUC43_32270 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CUC43_32330 ENOG4105EWM Histidine kinase CUC43_32480 ENOG4105E1K spore germination protein CUC43_32500 ENOG4105C19 ABC transporter CUC43_32555 ENOG4106WTF Glycosyl transferase, family 2 CUC43_32575 ENOG4105D13 transposase CUC43_32600 ENOG4105K70 DNA-binding protein CUC43_32605 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CUC43_32610 ENOG4105KRN Transcriptional regulator, abrb family CUC43_32640 ENOG4105CEY Amp-dependent synthetase and ligase CUC43_32685 ENOG4105D7V transposase CUC43_32790 ENOG4108IMY Transcriptional regulator CUC43_32885 ENOG4105E80 TraG TraD family protein CUC43_33010 ENOG41085W3 Transposase CUC43_33020 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CUC43_33035 ENOG4105EKQ RNA-directed DNA polymerase CUC43_33050 ENOG4105KRN Transcriptional regulator, abrb family CUC43_33120 ENOG4106WTF Glycosyl transferase, family 2 CUC43_33220 ENOG4107RCH Diaminopropionate ammonia-lyase CUC43_33240 ENOG4105CPF Cell wall formation (By similarity) CUC43_33270 ENOG4105IYK transposase CUC43_33315 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CUC43_33455 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CUC43_33570 ENOG4105K4H Nlp p60 protein CUC43_33605 ENOG41085W3 Transposase CUC43_33705 ENOG4105CNU cell division protein FtsK CUC43_33725 ENOG4105EFZ amidohydrolase CUC43_33740 ENOG4105KRN Transcriptional regulator, abrb family CUC43_33745 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CUC43_33750 ENOG4105K70 DNA-binding protein CUC43_33910 ENOG4105C19 ABC transporter CUC43_33950 ENOG4105WFK nuclease CUC43_34015 ENOG4107QJE Chromosome Partitioning Protein