locus-tag class description MC28_0001 ENOG41080XQ Signal transduction protein with cbs domains MC28_0005 ENOG4105ETU transcriptional activator (TenA MC28_0007 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MC28_0009 ENOG4108VEU Thiamine monophosphate synthase MC28_0010 ENOG41080HI glycine oxidase MC28_0013 ENOG4105D06 uba thif-type nad fad binding protein MC28_0014 ENOG4105DWF phosphomethylpyrimidine kinase MC28_0019 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) MC28_0020 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) MC28_0023 ENOG4108INS Transcriptional regulator MC28_0027 ENOG4105CNN ABC, transporter MC28_0032 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein MC28_0034 ENOG4105K63 Thioredoxin MC28_0038 ENOG4108B31 Spore germination protein MC28_0042 ENOG4107Y03 Nitroreductase MC28_0043 ENOG4105ED1 spovr family MC28_0048 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase MC28_0049 ENOG4105XTG Pfam:DUF156 MC28_0050 ENOG4105VFE sira family MC28_0051 ENOG4107TPS domain protein MC28_0052 ENOG4105VFE sira family MC28_0053 ENOG4105VFE sira family MC28_0054 ENOG41085GJ domain protein MC28_0055 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase MC28_0056 ENOG41087NI Sulfite exporter TauE/SafE MC28_0058 ENOG4108KGH TRANSCRIPTIONal MC28_0063 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein MC28_0064 ENOG4105CZM Major Facilitator MC28_0066 ENOG4105EMD TRANSCRIPTIONal MC28_0067 ENOG4105VCP PTS System MC28_0068 ENOG4105VZJ PTS System MC28_0072 ENOG41069ER domain protein MC28_0073 ENOG4107RBB ABC transporter, permease MC28_0074 ENOG4105C19 ABC transporter MC28_0087 ENOG4107T5V SNARE associated Golgi MC28_0094 ENOG4105CUB amino acid MC28_0095 ENOG4107RWR Sodium hydrogen exchanger MC28_0097 ENOG4106KNT transcriptional regulator MC28_0106 ENOG4108YXU transcriptional regulator AsnC family MC28_0112 ENOG4105KPY Small multidrug resistance protein MC28_0113 ENOG4105KPY Small multidrug resistance protein MC28_0118 ENOG4105NF4 modulator of drug activity MC28_0120 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) MC28_0121 ENOG4105E5W Transporter MC28_0123 ENOG4107RKG DJ-1/PfpI family MC28_0125 ENOG4105D5Q Arginine ornithine antiporter MC28_0126 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) MC28_0127 ENOG4105C26 Dehydrogenase MC28_0129 ENOG4105BZ1 (ABC) transporter MC28_0130 ENOG4105BZ1 (ABC) transporter MC28_0132 ENOG4105DRP amino acid AbC transporter MC28_0133 ENOG4105CDA abc transporter atp-binding protein MC28_0136 ENOG410839P MC28_0141 ENOG4107FQX Alpha-acetolactate decarboxylase MC28_0145 ENOG4105D4P Coproporphyrinogen iii oxidase MC28_0148 ENOG4105CHH sulfate transporter MC28_0150 ENOG4105CGU Enoyl-CoA hydratase MC28_0154 ENOG4105DER m42 family MC28_0160 ENOG4105D5U fad dependent oxidoreductase MC28_0165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC28_0166 ENOG4105C3U ABC transporter MC28_0167 ENOG4108JQ7 (ABC) transporter MC28_0177 ENOG4105CSH Transporter MC28_0179 ENOG4108MRH transcriptional regulatory protein MC28_0181 ENOG4105M6F mutator MutT protein MC28_0185 ENOG4105CDU Replicative dna helicase MC28_0191 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC28_0199 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MC28_0201 ENOG4105CID antiterminator MC28_0202 ENOG4105C5Y PTS System MC28_0203 ENOG4105CS2 ec 3.2.1.21 MC28_0205 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase MC28_0211 ENOG4105F27 Major Facilitator MC28_0217 ENOG4105CMT Dihydroxyacetone kinase MC28_0219 ENOG4105CMT Dihydroxyacetone kinase MC28_0221 ENOG410847I Transcriptional regulator, BadM Rrf2 family MC28_0224 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_0225 ENOG41062D9 Histidine kinase MC28_0235 ENOG4105WN5 stage II sporulation protein MC28_0239 ENOG4108MJI response regulator MC28_0240 ENOG4105BZU Histidine kinase MC28_0241 ENOG4105BZU Histidine kinase MC28_0254 ENOG4107VRP DNA repair exonuclease MC28_0255 ENOG4106D4I domain protein MC28_0263 ENOG4108MUZ hydrolase MC28_0265 ENOG41067QW Transcriptional regulator MC28_0266 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator MC28_0269 ENOG4105C6V Glycerol-3-phosphate dehydrogenase MC28_0270 ENOG4105EMN RNA polymerase sigma factor MC28_0272 ENOG4105CNI cell division protein FtsW MC28_0274 ENOG4105EEM helicase MC28_0276 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MC28_0280 ENOG4105K59 histidine triad (HIT) protein MC28_0287 ENOG410905X membrane-flanked domain protein MC28_0288 ENOG4105CKV Membrane MC28_0298 ENOG410905X membrane-flanked domain protein MC28_0299 ENOG4105CKV Membrane MC28_0300 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation MC28_0301 ENOG4105BZ4 penicillin-binding protein MC28_0303 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) MC28_0304 ENOG4105C1Q protoporphyrinogen oxidase MC28_0310 ENOG4105NA0 Transcriptional regulator MC28_0313 ENOG4105ECB domain protein MC28_0322 ENOG4106AXD MC28_0323 ENOG4108RQ5 Beta-lactamase domain-containing protein MC28_0324 ENOG4105DF9 Lipoate-protein, ligase MC28_0326 ENOG4105CEY Amp-dependent synthetase and ligase MC28_0330 ENOG4107RN3 metallophosphoesterase MC28_0332 ENOG4107TVP HD domain protein MC28_0334 ENOG4108AEY RNA polymerase sigma factor MC28_0335 ENOG41086D8 Transcriptional regulator MC28_0338 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC28_0344 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 MC28_0345 ENOG4105C8Q Methyl-accepting chemotaxis MC28_0347 ENOG4107QP3 malate synthase g MC28_0352 ENOG4105VEQ Cold shock protein MC28_0354 ENOG4105XVF Competence transcription factor MC28_0359 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) MC28_0367 ENOG4105ERH Fumarylacetoacetate hydrolase MC28_0372 ENOG4105CAQ asparagine synthetase MC28_0374 ENOG4105CH6 catalase MC28_0375 ENOG4105BZU Histidine kinase MC28_0378 ENOG4105QNR S1 RNA binding domain protein MC28_0383 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MC28_0385 ENOG4107AYK membrAne MC28_0386 ENOG41073B9 MC28_0388 ENOG4108KP7 hydrolase MC28_0390 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit MC28_0395 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MC28_0396 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MC28_0399 ENOG4105C31 Tryptophanyl-tRNA synthetase MC28_0402 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MC28_0403 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC28_0405 ENOG4108JQ7 (ABC) transporter MC28_0408 ENOG4105UQX Mate efflux family protein MC28_0413 ENOG4108ZCF integral membrane protein MC28_0415 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MC28_0417 ENOG4105DPN Oligoendopeptidase f MC28_0420 ENOG4108Z18 K06886 hemoglobin MC28_0421 ENOG4105MIX Adenylate cyclase MC28_0424 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) MC28_0425 ENOG4105EMS pseudouridine synthase MC28_0429 ENOG4105K64 Glycosyl transferase, family 2 MC28_0434 ENOG4107TVC Glycosyl transferase, family 2 MC28_0439 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase MC28_0441 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase MC28_0456 ENOG4105CK7 Sodium proline symporter MC28_0458 ENOG4105CRQ synthase (Component I) MC28_0459 ENOG4105DDQ anthranilate synthase MC28_0463 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) MC28_0479 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MC28_0483 ENOG4105C7S Dehydrogenase MC28_0484 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 MC28_0485 ENOG4105VZ8 Transcriptional regulator MC28_0492 ENOG4108IUX (ABC) transporter MC28_0493 ENOG4105RHA ABC transporter, permease MC28_0499 ENOG4105VTR Integrase MC28_0505 ENOG4105DZ1 carboxypeptidase MC28_0506 ENOG4105VFR signal peptidase MC28_0513 ENOG4105C26 Dehydrogenase MC28_0517 ENOG4105D38 putrescine abc transporter MC28_0518 ENOG4107RUE extracellular solute-binding protein family 1 MC28_0522 ENOG4108YBP pseudouridine synthase MC28_0524 ENOG4105K4I Scp-like extracellular MC28_0525 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) MC28_0526 ENOG4105CQB FAD linked oxidase domain protein MC28_0529 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_0530 ENOG4105BZU Histidine kinase MC28_0531 ENOG4105JXH GntR family transcriptional regulator MC28_0535 ENOG4106A3R peptidase MC28_0537 ENOG4108QTI )-transporter MC28_0538 ENOG4107TS3 membrane protein, TerC MC28_0539 ENOG4105CZN Potassium uptake protein MC28_0540 ENOG410681C small acid-soluble spore protein MC28_0541 ENOG4108Z7G MaoC domain protein dehydratase MC28_0545 ENOG4105CHR reductase MC28_0551 ENOG4105C4Y ABC transporter MC28_0552 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MC28_0553 ENOG4107RCV ABC transporter, permease MC28_0557 ENOG4105E98 transcriptional regulator DeoR family MC28_0561 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) MC28_0563 ENOG4105PXI polysaccharide deacetylase MC28_0565 ENOG4105BZU Histidine kinase MC28_0566 ENOG41090MY MarR family Transcriptional regulator MC28_0568 ENOG4106DF1 MC28_0570 ENOG4105BZU Histidine kinase MC28_0571 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) MC28_0572 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase MC28_0573 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) MC28_0578 ENOG4108R6G acetyltransferase MC28_0581 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) MC28_0584 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) MC28_0585 ENOG4105CUB amino acid MC28_0586 ENOG4105D82 Glutamate dehydrogenase MC28_0589 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC28_0590 ENOG4105C26 Dehydrogenase MC28_0591 ENOG4105C8Y Acetylornithine aminotransferase MC28_0592 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family MC28_0595 ENOG4105CJ1 ABC, transporter MC28_0603 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A MC28_0604 ENOG4105EA8 2-Nitropropane dioxygenase MC28_0605 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD MC28_0607 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MC28_0612 ENOG4105NQC Flavodoxin MC28_0619 ENOG4107QMU Mate efflux family protein MC28_0620 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) MC28_0627 ENOG4105CZN Potassium uptake protein MC28_0628 ENOG41063Y9 MC28_0629 ENOG4105KBJ sporulation protein ytfj MC28_0633 ENOG4105CM2 brancheD-chain amino acid aminotransferase MC28_0634 ENOG4105C7K acetolactate synthase MC28_0635 ENOG4108ZP8 Acetolactate synthase small subunit MC28_0639 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) MC28_0645 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) MC28_0649 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase MC28_0650 ENOG4107RVV histidinol phosphate phosphatase, hisj family MC28_0652 ENOG4105C5I Dehydrogenase MC28_0653 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase MC28_0654 ENOG4105E0M Sulfatase MC28_0656 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) MC28_0660 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) MC28_0661 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) MC28_0663 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MC28_0664 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein MC28_0665 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein MC28_0666 ENOG4105C8J )-transporter MC28_0671 ENOG4105DFD Na H antiporter MC28_0675 ENOG4105ENE Histidine kinase MC28_0676 ENOG4105WH1 Two component transcriptional regulator luxr family MC28_0679 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) MC28_0688 ENOG4105CJ3 phosphate transporter MC28_0689 ENOG4107GRR phosphate transport regulator MC28_0690 ENOG4105BZ4 penicillin-binding protein MC28_0693 ENOG4105BZU Histidine kinase MC28_0694 ENOG4105I3N Conserved Protein MC28_0697 ENOG4105BZU Histidine kinase MC28_0703 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MC28_0704 ENOG4105DZ1 carboxypeptidase MC28_0705 ENOG4108JIC nucleoside recognition domain protein MC28_0707 ENOG4105FE9 pseudouridine synthase MC28_0709 ENOG4107TWT Cytochrome c biogenesis protein MC28_0710 ENOG4105CRE cytochrome C MC28_0711 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_0712 ENOG4105BZU Histidine kinase MC28_0713 ENOG4108WBT adenosyltransferase MC28_0714 ENOG41063SB peptidase MC28_0716 ENOG4108SAX Membrane MC28_0718 ENOG4105T7X MC28_0719 ENOG4105C9U ATP-dependent DNA helicase RecQ MC28_0720 ENOG4105I7S Abortive infection protein MC28_0722 ENOG4107RGJ metallophosphoesterase MC28_0723 ENOG4108XDN Transcriptional regulator MC28_0724 ENOG4108S6Z Negative regulator of genetic competence MC28_0729 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase MC28_0730 ENOG4105HDK L-asparaginase MC28_0733 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) MC28_0736 ENOG4105S2F MC28_0737 ENOG41065D1 MC28_0743 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) MC28_0746 ENOG4105XXQ heptaprenyl diphosphate synthase component I MC28_0748 ENOG4105EAH synthase MC28_0749 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) MC28_0753 ENOG41068YB TPR repeat-containing protein MC28_0756 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) MC28_0764 ENOG4108JYZ YitT family MC28_0765 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase MC28_0768 ENOG4105FJR Lmbe family MC28_0769 ENOG4105CPK Glycosyl transferase (Group 1 MC28_0776 ENOG4105DVT helicase MC28_0777 ENOG4105YAC MC28_0781 ENOG4105CSM endonuclease III MC28_0783 ENOG4105BZ4 penicillin-binding protein MC28_0793 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) MC28_0794 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) MC28_0795 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MC28_0809 ENOG4105T6C Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps MC28_0815 ENOG4105CTD carboxy-peptidase MC28_0818 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) MC28_0820 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) MC28_0821 ENOG4105C2W permease MC28_0822 ENOG4105DHF Membrane MC28_0823 ENOG410890F Dynamin family MC28_0825 ENOG4108W0I acetyltransferase MC28_0827 ENOG4105KHC sulfurtransferase MC28_0832 ENOG4106032 Glutathionylspermidine synthase MC28_0838 ENOG4108SZE gCN5-related N-acetyltransferase MC28_0842 ENOG41081VK Ribonuclease MC28_0855 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MC28_0857 ENOG4107RWR Sodium hydrogen exchanger MC28_0858 ENOG4108Z5V transcriptional regulator, merr family MC28_0860 ENOG4105H67 Protein of unknown function (DUF421) MC28_0873 ENOG4107R0U MotA TolQ exbB proton channel MC28_0874 ENOG4105ER2 Ompa motb domain protein MC28_0876 ENOG4105CBS Chea signal transduction histidine kinase MC28_0877 ENOG4105DD5 Flagellar motor switch protein MC28_0880 ENOG4105BZU Histidine kinase MC28_0884 ENOG4105E1Q flagellar hook-associated protein MC28_0885 ENOG4105DTJ flagellar hook-associated protein MC28_0889 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) MC28_0890 ENOG4108ZC9 flagellar basal-body rod protein flgc MC28_0891 ENOG41075Z6 flagellar hook-basal body complex protein fliE MC28_0892 ENOG4107U2N Flagellar M-ring protein MC28_0893 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MC28_0899 ENOG4105BZE flagellar hook protein, FlgE MC28_0902 ENOG4107R88 Chemotaxis protein (CheV) MC28_0903 ENOG4106VV5 Motility gene repressor MogR MC28_0904 ENOG4105I03 Flagellin MC28_0905 ENOG4105I03 Flagellin MC28_0906 ENOG4105E4C Lytic transglycosylase catalytic MC28_0908 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) MC28_0909 ENOG4105DD5 Flagellar motor switch protein MC28_0911 ENOG4105CN7 Flagellar biosynthetic protein FliP MC28_0912 ENOG4105VS8 Flagellar biosynthetic protein fliq MC28_0914 ENOG4105D00 flagellar biosynthetic protein flhB MC28_0915 ENOG4105D7B Flagellar biosynthesis protein flha MC28_0916 ENOG4105FZW flagellar biosynthesis regulator FlhF MC28_0917 ENOG4105KTQ flagellar basal-body rod protein MC28_0925 ENOG4105KAC Antibiotic biosynthesis monooxygenase MC28_0930 ENOG4105DUM transcriptional regulator, lysR family MC28_0931 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) MC28_0932 ENOG4105C4Y ABC transporter MC28_0933 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component MC28_0941 ENOG4105CVJ phosphoglycerate mutase MC28_0943 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) MC28_0945 ENOG4105K56 Transcriptional regulator MC28_0947 ENOG4105CAQ asparagine synthetase MC28_0951 ENOG4105PGM cation diffusion facilitator family transporter MC28_0953 ENOG4105DRR Transcriptional regulator, GntR family MC28_0954 ENOG4108UZ3 Transporter MC28_0956 ENOG4105CKI cobalamin synthesis protein MC28_0957 ENOG4108PJD permease MC28_0960 ENOG4105DFD Na H antiporter MC28_0961 ENOG4105VUF Transcriptional regulator MC28_0962 ENOG4105EMU Dehydrogenase MC28_0963 ENOG4105C9Q fumarate hydratase class II MC28_0967 ENOG4107QJQ Mate efflux family protein MC28_0968 ENOG4105EC3 peptidase S51, dipeptidase E MC28_0972 ENOG4107QIV Cytochrome c biogenesis protein MC28_0973 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MC28_0977 ENOG4106BRA Membrane MC28_0984 ENOG4105CJ1 ABC, transporter MC28_0988 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) MC28_0990 ENOG4108IJ0 Aspartate ammonia-lyase MC28_0991 ENOG4105C6K Malic enzyme MC28_0996 ENOG4105C0D helicase MC28_1000 ENOG41067QW Transcriptional regulator MC28_1004 ENOG4105FVX MC28_1005 ENOG4105E09 nadh pyrophosphatase MC28_1012 ENOG4105CSR polyphosphate kinase 2 MC28_1013 ENOG4105DXI Major Facilitator superfamily MC28_1016 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MC28_1017 ENOG4105EU0 Major facilitator Superfamily MC28_1018 ENOG4105C6T cysteine synthase MC28_1022 ENOG4105C8J )-transporter MC28_1024 ENOG4105X5K response regulator receiver protein MC28_1025 ENOG4105H67 Protein of unknown function (DUF421) MC28_1029 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) MC28_1030 ENOG4105CHR reductase MC28_1031 ENOG4105CM2 brancheD-chain amino acid aminotransferase MC28_1032 ENOG4105C7K acetolactate synthase MC28_1034 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase MC28_1036 ENOG4105C7B Threonine dehydratase MC28_1040 ENOG4105C6X Major Facilitator MC28_1041 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b MC28_1043 ENOG4107X42 5-methylthioadenosine S-adenosylhomocysteine nucleosidase MC28_1049 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E MC28_1050 ENOG41068WN MC28_1054 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) MC28_1057 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) MC28_1059 ENOG4105C0X amino acid MC28_1063 ENOG410829K Lysine exporter protein (Lyse ygga) MC28_1064 ENOG4107RHR regulatoR MC28_1066 ENOG4105D9N nucleoside MC28_1067 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) MC28_1068 ENOG4105KG3 cytidine deaminase MC28_1074 ENOG410811B TRANSCRIPTIONal MC28_1077 ENOG4107RAQ aminopeptidase MC28_1078 ENOG4107R16 Multicopper oxidase MC28_1080 ENOG4105F6J Alpha beta hydrolase fold MC28_1090 ENOG4105C44 Serine transporter MC28_1094 ENOG4105CJZ response regulator MC28_1100 ENOG4105CNI cell division protein FtsW MC28_1101 ENOG4105CJW magnesium transporter MC28_1107 ENOG4105F6J Alpha beta hydrolase fold MC28_1115 ENOG4105C5Q Transcriptional regulator MC28_1121 ENOG4108T5E Copper resistance protein MC28_1122 ENOG4105KTB nuclear export factor GLE1 MC28_1123 ENOG4107RT3 EamA-like transporter family MC28_1124 ENOG4105GZI Transcriptional regulator MC28_1125 ENOG4108Z40 Transcriptional regulator MC28_1126 ENOG4107ZXU DSBA oxidoreductase MC28_1127 ENOG4108TVJ Nitroreductase MC28_1129 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MC28_1130 ENOG4106F5Q Membrane MC28_1133 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MC28_1135 ENOG4105CKI cobalamin synthesis protein MC28_1137 ENOG4105C0Z ABC transporter MC28_1139 ENOG4105C32 Amino acid ABC transporter (Permease) MC28_1141 ENOG4105EGI Transcriptional regulator MC28_1147 ENOG4105C4M (Ubiquinol oxidase) subunit I MC28_1148 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MC28_1161 ENOG4105EFI regulatoR MC28_1162 ENOG4105BZU Histidine kinase MC28_1166 ENOG41075D4 Aminoglycoside 6-adenylyltransferase MC28_1167 ENOG4108ZJ4 polysaccharide deacetylase MC28_1168 ENOG4106AKJ MC28_1171 ENOG4105D6E homoserine dehydrogenase MC28_1176 ENOG4108KGH TRANSCRIPTIONal MC28_1178 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC28_1179 ENOG4105BZU Histidine kinase MC28_1180 ENOG4107VMI polysaccharide deacetylase MC28_1182 ENOG4105KT7 mgtC SapB transporter MC28_1183 ENOG4105VRR gCN5-related N-acetyltransferase MC28_1185 ENOG4105DUU IucA IucC family protein MC28_1186 ENOG4105CEY Amp-dependent synthetase and ligase MC28_1189 ENOG4108WBH protein TIM barrel MC28_1190 ENOG4105YWU small acid-soluble spore protein MC28_1192 ENOG4108ZUB Lysine exporter protein (Lyse ygga) MC28_1193 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MC28_1215 ENOG4105EFC phage portal protein HK97 family MC28_1223 ENOG4105KRN Transcriptional regulator, abrb family MC28_1225 ENOG4105YVS arsR family transcriptional regulator MC28_1226 ENOG4105CPC Aldo Keto reductase MC28_1234 ENOG4108K88 Membrane MC28_1235 ENOG4108WPJ Ferritin-like domain MC28_1238 ENOG4105DEN Luciferase family MC28_1241 ENOG4105VMI -acetyltransferase MC28_1242 ENOG4107QM2 Aldo Keto reductase MC28_1243 ENOG4105CKI cobalamin synthesis protein MC28_1245 ENOG4105DSE periplasmic solute binding protein MC28_1249 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MC28_1258 ENOG4107T5V SNARE associated Golgi MC28_1261 ENOG4108PJD permease MC28_1263 ENOG4108S4H thioesterase Superfamily protein MC28_1268 ENOG4105SXS Protein of unknown function (DUF456) MC28_1269 ENOG4105C37 (CBS) domain MC28_1275 ENOG4108Z7R Chaperone CsaA MC28_1278 ENOG4108ZRV stage ii sporulation protein p MC28_1280 ENOG4108VXD carboxy-peptidase MC28_1282 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) MC28_1286 ENOG4108ZRV stage ii sporulation protein p MC28_1288 ENOG4108X4Q Hydrolase MC28_1289 ENOG41082F9 transcriptional regulator MC28_1290 ENOG4105D94 Major Facilitator Superfamily MC28_1291 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MC28_1294 ENOG41087PP glycosyltransferase MGT family MC28_1295 ENOG4108JYZ YitT family MC28_1296 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MC28_1301 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MC28_1305 ENOG4106PAW secretion accessory protein EsaA YueB MC28_1307 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) MC28_1317 ENOG4105KBJ sporulation protein ytfj MC28_1322 ENOG4108KQJ Type 11 methyltransferase MC28_1326 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily MC28_1328 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein MC28_1333 ENOG4105CNW domain protein MC28_1338 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MC28_1341 ENOG4108IUE nitrate reductase beta subunit MC28_1342 ENOG4105R3A Nitrate reductase MC28_1344 ENOG4107V6Q Cyclic nucleotide-binding domain MC28_1345 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MC28_1346 ENOG4105D06 uba thif-type nad fad binding protein MC28_1347 ENOG4105CVM Molybdenum cofactor synthesis domain protein MC28_1348 ENOG4108ZAF Molybdopterin MC28_1352 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein MC28_1353 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein MC28_1354 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) MC28_1355 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit MC28_1356 ENOG4108IFG nitrite reductase, (NAD(P)H) MC28_1357 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) MC28_1364 ENOG4105D9U N-acetyltransferase MC28_1372 ENOG4105MCT stage V sporulation protein S MC28_1375 ENOG4105C5H ABC transporter MC28_1384 ENOG4107YX5 Pfam:DUF548 MC28_1385 ENOG4105C75 arginyL-tRNA synthetase MC28_1388 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) MC28_1390 ENOG41060BG Tetr family transcriptional regulator MC28_1393 ENOG4105C5S asparaginyl-tRNA synthetase MC28_1394 ENOG4105C8J )-transporter MC28_1398 ENOG4107XGZ Hydrolase MC28_1399 ENOG4105CY2 Citrate transporter MC28_1403 ENOG4105KD7 acetyltransferase MC28_1404 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase MC28_1407 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 MC28_1410 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) MC28_1414 ENOG4107RVG penicillin-binding protein MC28_1416 ENOG4105E9Q Acyl-transferase MC28_1417 ENOG4108UT2 hemolysin iii MC28_1419 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) MC28_1421 ENOG4108RCR degv family MC28_1422 ENOG4105E8R UPF0173 metal-dependent hydrolase MC28_1423 ENOG4108KF3 Electron transport protein SCO1 SenC MC28_1424 ENOG4107Y70 Heat shock protein MC28_1425 ENOG4105CAQ asparagine synthetase MC28_1428 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase MC28_1429 ENOG4108MES Periplasmic binding protein MC28_1430 ENOG4105F0I Aminotransferase MC28_1435 ENOG4105D8X mechanosensitive ion channel MC28_1436 ENOG4105BZU Histidine kinase MC28_1437 ENOG4105WH1 Two component transcriptional regulator luxr family MC28_1438 ENOG4106KNT transcriptional regulator MC28_1451 ENOG4108IJ8 ABC transporter MC28_1452 ENOG4105E90 ABC transporter MC28_1459 ENOG4105C37 (CBS) domain MC28_1464 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MC28_1467 ENOG4107S4Y M20 DapE family protein YgeY MC28_1468 ENOG4108TSC N-acetyltransferase MC28_1470 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein MC28_1479 ENOG410841Q phosphoesterase PA-phosphatase related protein MC28_1483 ENOG4105VTR Integrase MC28_1498 ENOG4108NF7 phage-type endonuclease MC28_1499 ENOG4108PNI recT protein MC28_1530 ENOG410907Z n-acetylmuramoyl-l-alanine amidase MC28_1545 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MC28_1551 ENOG4105CHR reductase MC28_1554 ENOG4105BZ4 penicillin-binding protein MC28_1555 ENOG4105CZM Major Facilitator MC28_1558 ENOG4105DXD 2-methylcitrate dehydratase MC28_1559 ENOG4105CR4 methylisocitrate lyase MC28_1560 ENOG4105C1G acyl-Coa dehydrogenase MC28_1561 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase MC28_1563 ENOG4105N14 lysine exporter protein LysE YggA MC28_1564 ENOG4105E39 Enoyl-CoA hydratase MC28_1567 ENOG4107RFY SbcCD D subunit MC28_1573 ENOG4105FCD Major Facilitator MC28_1574 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase MC28_1575 ENOG4105E4F Isochorismate synthase MC28_1576 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase MC28_1577 ENOG4105WQI isochorismatase MC28_1578 ENOG4105CEY Amp-dependent synthetase and ligase MC28_1579 ENOG4105WQT MbtH domain protein MC28_1580 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC28_1583 ENOG4105K70 DNA-binding protein MC28_1587 ENOG4105BZG amino acid carrier protein MC28_1590 ENOG4105FE9 pseudouridine synthase MC28_1591 ENOG4105C22 threonyL-tRNA synthetase MC28_1592 ENOG4105C19 ABC transporter MC28_1594 ENOG4107SKW Inherit from COG: Alpha beta hydrolase MC28_1600 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) MC28_1603 ENOG41081I9 integral membrane protein MC28_1605 ENOG4108Y4K DNA-binding transcriptional activator MC28_1607 ENOG41075H3 AraC family transcriptional regulator MC28_1613 ENOG4105EXC Acyl-transferase MC28_1616 ENOG4105BZU Histidine kinase MC28_1618 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_1622 ENOG4107MII Sugar-specific transcriptional regulator TrmB MC28_1625 ENOG41067SE Tetr family transcriptional regulator MC28_1626 ENOG4105EYF MMPL domain protein MC28_1630 ENOG4105WCN acetyltransferase MC28_1635 ENOG4105C1Q protoporphyrinogen oxidase MC28_1637 ENOG41068WN MC28_1643 ENOG4107V2S Transcriptional regulator MC28_1644 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MC28_1645 ENOG4105DND Transcriptional regulator MC28_1646 ENOG4108JPW Aminotransferase MC28_1647 ENOG4108RPX mosc domain containing protein MC28_1652 ENOG4108VP3 Lysine exporter protein (LysE YggA) MC28_1653 ENOG4108JCI Transcriptional regulator MC28_1662 ENOG4108KPJ rna polymerase sigma factor MC28_1667 ENOG4105F32 YngK protein MC28_1670 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) MC28_1671 ENOG4105RD7 BadF BadG BcrA BcrD MC28_1672 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) MC28_1673 ENOG4107STF Involved in phosphonate degradation (By similarity) MC28_1677 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) MC28_1680 ENOG4105C1J atp-dependent rna helicase MC28_1683 ENOG4108I0C methyltransferase MC28_1684 ENOG4107RA9 decarboxylase MC28_1686 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) MC28_1691 ENOG4105CIN aminoacyl-histidine dipeptidase MC28_1698 ENOG4105KRN Transcriptional regulator, abrb family MC28_1700 ENOG4105EJ9 Membrane MC28_1701 ENOG4105EQK -acetyltransferase MC28_1706 ENOG4107RVG penicillin-binding protein MC28_1709 ENOG4107RF6 penicillin-binding protein MC28_1710 ENOG4107RF6 penicillin-binding protein MC28_1720 ENOG4108M1A Chitin-binding protein MC28_1721 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_1723 ENOG4107RGJ metallophosphoesterase MC28_1725 ENOG4105CJ1 ABC, transporter MC28_1727 ENOG4107Z3H Transcriptional regulator, TetR family MC28_1729 ENOG4105C1G acyl-Coa dehydrogenase MC28_1731 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit MC28_1733 ENOG4105E39 Enoyl-CoA hydratase MC28_1734 ENOG4107QX3 carboxylase MC28_1735 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MC28_1754 ENOG4105T9C HD domain MC28_1756 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) MC28_1760 ENOG41075H3 AraC family transcriptional regulator MC28_1767 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) MC28_1770 ENOG41066YJ Beta-lactamase MC28_1772 ENOG4107EXU Short-chain dehydrogenase reductase Sdr MC28_1773 ENOG4105KVH Transcriptional regulator MC28_1774 ENOG41089UC methyltransferase, type 11 MC28_1780 ENOG4105SX7 Transporter MC28_1787 ENOG4108V4B ThiJ pfpI MC28_1789 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein MC28_1790 ENOG4105DK7 lysyl-tRNA synthetase MC28_1797 ENOG4107RSM transcriptional regulator MC28_1798 ENOG4105CPC Aldo Keto reductase MC28_1806 ENOG4105D6E homoserine dehydrogenase MC28_1809 ENOG4105ETU transcriptional activator (TenA MC28_1837 ENOG410667J hydrolase MC28_1838 ENOG4105BZU Histidine kinase MC28_1839 ENOG4107RF6 penicillin-binding protein MC28_1840 ENOG4105C3F Signal peptidase i MC28_1844 ENOG4108JJB ABC transporter MC28_1847 ENOG4108HGU Histidine kinase MC28_1850 ENOG4105CB2 alcohol dehydrogenase MC28_1851 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase MC28_1852 ENOG4105CJN penicillin-binding protein MC28_1864 ENOG4107SFI Major Facilitator superfamily MC28_1868 ENOG4107VXM glycerophosphoryl diester phosphodiesterase MC28_1873 ENOG4107Y9U Membrane MC28_1881 ENOG4105FCD Major Facilitator MC28_1883 ENOG4105E09 nadh pyrophosphatase MC28_1884 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MC28_1892 ENOG4108XI2 Domain of unknown function (DUF1963) MC28_1897 ENOG4108NRW Phospholipase, patatin family MC28_1898 ENOG4105KWG Pfam:DUF1696 MC28_1900 ENOG4108YYS metal-dependent hydrolase (By similarity) MC28_1905 ENOG4105PKS Excinuclease abc c subunit domain protein MC28_1911 ENOG4107VFR oxidoreductase MC28_1917 ENOG4105U0R haloacid dehalogenase-like hydrolase MC28_1918 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_1919 ENOG4105BZU Histidine kinase MC28_1925 ENOG4107WD8 ABC transporter, permease MC28_1929 ENOG4108IUM Glycogen debranching enzyme MC28_1931 ENOG4105CGH 5'-nucleotidase MC28_1934 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) MC28_1935 ENOG4105FDR Membrane MC28_1936 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MC28_1946 ENOG4105MSI germination protein ypeb MC28_1954 ENOG4107Z3H Transcriptional regulator, TetR family MC28_1956 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family MC28_1960 ENOG4105E98 transcriptional regulator DeoR family MC28_1965 ENOG4107QKR Dehydrogenase MC28_1969 ENOG4105E1F short-chain dehydrogenase reductase MC28_1975 ENOG4107SQ8 Glycine betaine MC28_1976 ENOG4108IJ7 Glycine betaine MC28_1978 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MC28_1982 ENOG41082BV acetyltransferase MC28_1985 ENOG4108M1A Chitin-binding protein MC28_1987 ENOG41087PP glycosyltransferase MGT family MC28_1992 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) MC28_1993 ENOG4105MSB protein, conserved in bacteria MC28_1998 ENOG4108Z7F N-acetyltransferase MC28_2003 ENOG4105EEM helicase MC28_2005 ENOG4105C9U ATP-dependent DNA helicase RecQ MC28_2013 ENOG4108M1A Chitin-binding protein MC28_2019 ENOG4105BZG amino acid carrier protein MC28_2020 ENOG4105C26 Dehydrogenase MC28_2021 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MC28_2022 ENOG4105CTU Proline racemase MC28_2023 ENOG4105CTU Proline racemase MC28_2024 ENOG41080HI glycine oxidase MC28_2026 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein MC28_2034 ENOG4105DCI Phosphohydrolase MC28_2035 ENOG4107T5V SNARE associated Golgi MC28_2036 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD MC28_2039 ENOG4105DTQ mandelate racemase muconate lactonizing MC28_2048 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) MC28_2049 ENOG4105BZU Histidine kinase MC28_2050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_2054 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 MC28_2055 ENOG4105DPN Oligoendopeptidase f MC28_2056 ENOG4105KEG ribosomal-protein-alanine acetyltransferase MC28_2057 ENOG4105EPR degv family MC28_2071 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) MC28_2072 ENOG4106K7D Major facilitator family transporter MC28_2077 ENOG4107BMA Transglycosylase associated protein MC28_2080 ENOG41089UC methyltransferase, type 11 MC28_2087 ENOG4105CHM Aminotransferase MC28_2093 ENOG4105DVE abc transporter atp-binding protein MC28_2102 ENOG4105C02 permease MC28_2104 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) MC28_2105 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component MC28_2106 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein MC28_2107 ENOG4105D7T ABC transporter MC28_2112 ENOG4108AQF aminoglycoside N(3)-acetyltransferase MC28_2125 ENOG4105C6T cysteine synthase MC28_2126 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase MC28_2129 ENOG4107VMI polysaccharide deacetylase MC28_2132 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC28_2133 ENOG4108ZCF integral membrane protein MC28_2135 ENOG4105C5H ABC transporter MC28_2136 ENOG4105EYF MMPL domain protein MC28_2137 ENOG41082JN Transcriptional regulator MC28_2143 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase MC28_2151 ENOG41069ER domain protein MC28_2153 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase MC28_2154 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) MC28_2155 ENOG4108YYH Nadph-dependent fmn reductase MC28_2159 ENOG4105D4B ABC, transporter MC28_2162 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane MC28_2164 ENOG4105DKT Transcriptional regulator MC28_2165 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) MC28_2167 ENOG41061GT Aldolase MC28_2172 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) MC28_2176 ENOG4107QK4 glycoside hydrolase, family 3 domain protein MC28_2177 ENOG41075H3 AraC family transcriptional regulator MC28_2180 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) MC28_2181 ENOG4105II7 pyrroline-5-carboxylate reductase MC28_2183 ENOG4107258 Transcriptional regulator MC28_2187 ENOG4105ECK Fatty Acid Desaturase MC28_2189 ENOG4105G6Z alkaline phosphatase MC28_2191 ENOG4105VMP Transcriptional regulator MC28_2196 ENOG41068WN MC28_2201 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MC28_2214 ENOG4105C7R Atpase associated with various cellular activities aaa_3 MC28_2216 ENOG41090AA MC28_2217 ENOG4106BHF MC28_2219 ENOG4108IBT Inherit from COG: transposase MC28_2224 ENOG4108TVJ Nitroreductase MC28_2225 ENOG4105FS7 Transcriptional regulator MC28_2230 ENOG4105CMR udp-glucose 4-epimerase MC28_2233 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) MC28_2234 ENOG4108XET gCN5-related N-acetyltransferase MC28_2240 ENOG4107XJU UPF0178 protein MC28_2250 ENOG410635A Membrane MC28_2252 ENOG4108IQI permease MC28_2254 ENOG4105F1N DNA alkylation repair MC28_2261 ENOG4107RF6 penicillin-binding protein MC28_2262 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) MC28_2269 ENOG4107258 Transcriptional regulator MC28_2273 ENOG4106N3A copper homeostasis protein cutc MC28_2274 ENOG4108ZHR arsR family transcriptional regulator MC28_2276 ENOG4105FDT acyl-CoA dehydrogenase MC28_2279 ENOG4105DWD nucleoside recognition domain protein MC28_2290 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) MC28_2293 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MC28_2298 ENOG4105CGH 5'-nucleotidase MC28_2300 ENOG4105CHJ isochorismatase hydrolase MC28_2312 ENOG4108606 TspO/MBR family MC28_2313 ENOG4105CVP deoxyribo-dipyrimidine photolyase MC28_2319 ENOG4108Q5U germination protein, ger(x)c family MC28_2320 ENOG4105E1K spore germination protein MC28_2322 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase MC28_2328 ENOG4105D6J arsenicaL-resistance protein MC28_2329 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase MC28_2330 ENOG41085FC arsR family transcriptional regulator MC28_2335 ENOG4108IG5 Transcriptional regulator MC28_2337 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) MC28_2341 ENOG4105E1K spore germination protein MC28_2342 ENOG4105F27 Major Facilitator MC28_2343 ENOG4105CHR reductase MC28_2344 ENOG4108YXU transcriptional regulator AsnC family MC28_2349 ENOG4105N0V mono-oxygenase ydhR MC28_2359 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) MC28_2360 ENOG4107ZY0 Phenazine biosynthesis-like protein MC28_2362 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC28_2363 ENOG4105K6H D-cysteine desulfhydrase MC28_2368 ENOG4108NNI Beta-lactamase domain-containing protein MC28_2369 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase MC28_2371 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) MC28_2375 ENOG4105JQZ Methyltransferase MC28_2379 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) MC28_2382 ENOG4105BZU Histidine kinase MC28_2384 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) MC28_2386 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A MC28_2390 ENOG4108JQ1 Dehydrogenase MC28_2412 ENOG4108VXD carboxy-peptidase MC28_2413 ENOG4105PNM synthesis protein MC28_2415 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MC28_2418 ENOG4105C3S Mate efflux family protein MC28_2419 ENOG4105C26 Dehydrogenase MC28_2420 ENOG4105MWK D-amino acid dehydrogenase, small subunit MC28_2423 ENOG4108ISG Major Facilitator MC28_2426 ENOG4107MII Sugar-specific transcriptional regulator TrmB MC28_2427 ENOG4105CZM Major Facilitator MC28_2439 ENOG4105CRW Short chain fatty acid transporter MC28_2441 ENOG4105DYS nad(p)h dehydrogenase (quinone) MC28_2453 ENOG4108K8S endonuclease I MC28_2455 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) MC28_2456 ENOG4108Z66 YbaK ebsC protein MC28_2460 ENOG4105KVH Transcriptional regulator MC28_2461 ENOG4108RCM Nitroreductase MC28_2468 ENOG4108PSK reductase MC28_2482 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase MC28_2483 ENOG4105DKQ ROK family MC28_2484 ENOG4106UW1 Major Facilitator superfamily MC28_2485 ENOG4108UW5 maltose o-acetyltransferase MC28_2486 ENOG4105C31 Tryptophanyl-tRNA synthetase MC28_2494 ENOG4105EV4 Multidrug resistance protein mdtH MC28_2499 ENOG4105C37 (CBS) domain MC28_2503 ENOG4105FAW cDP-glucose 4,6-dehydratase MC28_2507 ENOG4105DDN Pentapeptide repeat-containing protein MC28_2509 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) MC28_2510 ENOG4105CMG Carbohydrate kinase MC28_2511 ENOG4105C6Z Gluconate MC28_2514 ENOG4105CV1 Transketolase (EC 2.2.1.1) MC28_2515 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase MC28_2517 ENOG4105CIS alcohol dehydrogenase MC28_2518 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone MC28_2521 ENOG4105EWI Short-chain dehydrogenase reductase Sdr MC28_2524 ENOG4105C8Q Methyl-accepting chemotaxis MC28_2525 ENOG4108UX3 '-nucleotidase MC28_2526 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) MC28_2527 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) MC28_2528 ENOG4105KVH Transcriptional regulator MC28_2531 ENOG4105CV8 reductase MC28_2532 ENOG4105F27 Major Facilitator MC28_2534 ENOG41090KN UPF0303 protein MC28_2536 ENOG4105FS7 Transcriptional regulator MC28_2537 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA MC28_2538 ENOG4105CHH sulfate transporter MC28_2541 ENOG4105C44 Serine transporter MC28_2542 ENOG4105VMP Transcriptional regulator MC28_2549 ENOG4105KVH Transcriptional regulator MC28_2550 ENOG4108TZY GntR Family Transcriptional Regulator MC28_2551 ENOG4105D9R oxidoreductase MC28_2552 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase MC28_2555 ENOG4105KVH Transcriptional regulator MC28_2565 ENOG4105JAB phenazine biosynthesis protein, phzf family MC28_2570 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein MC28_2571 ENOG4105KVH Transcriptional regulator MC28_2574 ENOG4108ZJ4 polysaccharide deacetylase MC28_2589 ENOG4107YXZ hydrolase, family 25 MC28_2596 ENOG4105H3G oxidoreductase MC28_2603 ENOG4105CIS alcohol dehydrogenase MC28_2605 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MC28_2616 ENOG4108TN2 lmbE family MC28_2618 ENOG4107R3E Citrate transporter MC28_2620 ENOG4105WCN acetyltransferase MC28_2621 ENOG4108MES Periplasmic binding protein MC28_2622 ENOG4105EHG Permease protein MC28_2623 ENOG4105DQ5 transport system permease protein MC28_2624 ENOG4105NX3 Membrane MC28_2628 ENOG4107CUJ Protein of unknown function (DUF2690) MC28_2630 ENOG4107V2S Transcriptional regulator MC28_2634 ENOG4105C98 muts2 protein MC28_2635 ENOG4105E5K Alpha-amylase MC28_2636 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase MC28_2637 ENOG4105DPN Oligoendopeptidase f MC28_2642 ENOG4105FFC UPF0187 protein MC28_2645 ENOG4108A04 Beta-lactamase MC28_2648 ENOG4105EGI Transcriptional regulator MC28_2651 ENOG4107VXM glycerophosphoryl diester phosphodiesterase MC28_2654 ENOG41082BM Transcriptional regulator, arsr family MC28_2655 ENOG4105CIS alcohol dehydrogenase MC28_2662 ENOG4105CQB FAD linked oxidase domain protein MC28_2667 ENOG4105BZU Histidine kinase MC28_2669 ENOG4108VXD carboxy-peptidase MC28_2675 ENOG4105DQ6 Transposase MC28_2677 ENOG4105BZU Histidine kinase MC28_2679 ENOG4105KT7 mgtC SapB transporter MC28_2681 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase MC28_2682 ENOG41073R8 VanW family MC28_2685 ENOG4108R1P MC28_2688 ENOG4105VEQ Cold shock protein MC28_2696 ENOG410904N short-chain dehydrogenase reductase MC28_2698 ENOG4106IQC argininosuccinate lyase MC28_2701 ENOG4108IA2 Sodium pantothenate symporter MC28_2703 ENOG4105C26 Dehydrogenase MC28_2704 ENOG4105CHR reductase MC28_2706 ENOG4105EWU Squalene--hopene cyclase MC28_2708 ENOG4105FR1 rard protein MC28_2712 ENOG4105D1F ATP-binding protein MC28_2714 ENOG4108ZAF Molybdopterin MC28_2715 ENOG4105CVM Molybdenum cofactor synthesis domain protein MC28_2716 ENOG4105D06 uba thif-type nad fad binding protein MC28_2717 ENOG4105TMB Formate nitrite transporter MC28_2719 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) MC28_2720 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) MC28_2722 ENOG4108JB9 formate dehydrogenase MC28_2724 ENOG4105E1K spore germination protein MC28_2726 ENOG4108NHD germination protein MC28_2727 ENOG4105CUB amino acid MC28_2738 ENOG4107QJT sodium dicarboxylate symporter MC28_2739 ENOG4108KGH TRANSCRIPTIONal MC28_2741 ENOG4105EMN RNA polymerase sigma factor MC28_2743 ENOG4105CIG ABC transporter MC28_2745 ENOG4105D9R oxidoreductase MC28_2747 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MC28_2748 ENOG4105K4P CoA-binding domain protein MC28_2749 ENOG4105C0H protease MC28_2750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_2751 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) MC28_2752 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase MC28_2753 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) MC28_2754 ENOG4105W8X HesB YadR YfhF-family protein MC28_2759 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) MC28_2760 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MC28_2762 ENOG4108I0Z Aconitate hydratase MC28_2768 ENOG4105E5W Transporter MC28_2770 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) MC28_2774 ENOG4107F3J Amp-dependent synthetase and ligase MC28_2775 ENOG4107ZYJ bioY protein MC28_2776 ENOG4105CEY Amp-dependent synthetase and ligase MC28_2777 ENOG4108IMY Transcriptional regulator MC28_2785 ENOG4107AYK membrAne MC28_2787 ENOG4105BZU Histidine kinase MC28_2788 ENOG4105FBA Phospholipase Carboxylesterase MC28_2789 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase MC28_2790 ENOG4105CBC glutamate synthase MC28_2791 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase MC28_2792 ENOG4108VJ1 Transcriptional regulator (CarD family MC28_2793 ENOG4108903 Formimidoylglutamase MC28_2805 ENOG4107QIV Cytochrome c biogenesis protein MC28_2808 ENOG4105CH2 amidohydrolase MC28_2810 ENOG4105CJ1 ABC, transporter MC28_2813 ENOG4107RSM transcriptional regulator MC28_2815 ENOG41067MG lrgb family MC28_2822 ENOG4107YXZ hydrolase, family 25 MC28_2823 ENOG4105BZ1 (ABC) transporter MC28_2824 ENOG4105BZ1 (ABC) transporter MC28_2832 ENOG4105CGH 5'-nucleotidase MC28_2834 ENOG4108SVB resolvase MC28_2839 ENOG4105BZ1 (ABC) transporter MC28_2845 ENOG4105CAQ asparagine synthetase MC28_2846 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase MC28_2848 ENOG4105CPF Cell wall formation (By similarity) MC28_2849 ENOG4105D3Q Sugar transferase MC28_2856 ENOG4108KMV Glycosyl transferase (Group 1 MC28_2857 ENOG41068W6 Capsular polysaccharide biosynthesis protein MC28_2858 ENOG4107SJB teichoic acid biosynthesis MC28_2859 ENOG4108KMV Glycosyl transferase (Group 1 MC28_2860 ENOG4108PQP glycosyl transferase group 1 MC28_2864 ENOG4105C5F glutamine synthetase MC28_2865 ENOG4105KV4 Transcriptional regulator MC28_2866 ENOG4105CXI aluminum resistance protein MC28_2867 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) MC28_2868 ENOG4105EN6 Membrane MC28_2870 ENOG4106F1P AAA ATPase, central domain protein MC28_2875 ENOG4105DQ6 Transposase MC28_2879 ENOG41069ER domain protein MC28_2880 ENOG4105DM4 PTS System MC28_2881 ENOG4105DE4 1-phosphofructokinase MC28_2882 ENOG4105E98 transcriptional regulator DeoR family MC28_2883 ENOG4107QW4 alcohol dehydrogenase MC28_2884 ENOG4108SJC Membrane MC28_2887 ENOG4105C85 amino acid MC28_2891 ENOG4105TMB Formate nitrite transporter MC28_2894 ENOG4105C59 p-type ATPase MC28_2896 ENOG4105VPX protein, conserved in bacteria MC28_2901 ENOG4105E0A ABC, transporter MC28_2905 ENOG4105CGK Exodeoxyribonuclease III MC28_2907 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) MC28_2908 ENOG4105D03 DNA-3-methyladenine glycosylase II MC28_2915 ENOG4105BZU Histidine kinase MC28_2923 ENOG41067MG lrgb family MC28_2926 ENOG4107TTQ Alpha beta hydrolase fold MC28_2927 ENOG4107YEI lmbE family MC28_2928 ENOG4108S3Y transcriptional regulator MC28_2929 ENOG4105CS2 ec 3.2.1.21 MC28_2932 ENOG4105F0V Cell wall hydrolase MC28_2934 ENOG4105E0M Sulfatase MC28_2942 ENOG4105DQU oxidoreductase, subunit beta MC28_2943 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein MC28_2944 ENOG4108IGT Dipeptidase MC28_2945 ENOG4105MCT stage V sporulation protein S MC28_2946 ENOG4105D48 metallophosphoesterase MC28_2952 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase MC28_2955 ENOG4105XZV Protein of unknown function (DUF3243) MC28_2956 ENOG4108RKS Short-chain dehydrogenase reductase Sdr MC28_2960 ENOG4105UIB (ABC) transporter MC28_2961 ENOG4108JQ9 ABC transporter MC28_2962 ENOG4105DIH basic membrane MC28_2963 ENOG4105FDP GntR family transcriptional regulator MC28_2964 ENOG4107QZI cell division protein FtsK MC28_2966 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit MC28_2968 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) MC28_2970 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) MC28_2971 ENOG4108S0H Dipicolinic acid synthetase, b subunit MC28_2976 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MC28_2982 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MC28_2997 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MC28_3006 ENOG41069ER domain protein MC28_3007 ENOG4105K4H Nlp p60 protein MC28_3015 ENOG4105CDU Replicative dna helicase MC28_3022 ENOG4108IMY Transcriptional regulator MC28_3027 ENOG4105E35 Dipicolinate synthase subunit A MC28_3029 ENOG4105C1V Peptidase, M16 MC28_3033 ENOG4105DTN riboflavin biosynthesis protein ribF MC28_3037 ENOG4105VHM ribosomal protein MC28_3038 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination MC28_3039 ENOG4105CHV Transcription elongation factor NusA MC28_3041 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) MC28_3043 ENOG4105DZP Membrane-associated zinc metalloprotease MC28_3045 ENOG4105KNE Phosphatidate cytidylyltransferase MC28_3046 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) MC28_3049 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) MC28_3054 ENOG4108HE4 integrase family MC28_3056 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) MC28_3057 ENOG4105C79 DNA protecting protein DprA MC28_3058 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha MC28_3061 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) MC28_3066 ENOG4105VB6 UPF0109 protein MC28_3070 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) MC28_3071 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) MC28_3074 ENOG4105CHR reductase MC28_3075 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MC28_3078 ENOG4105CB5 ATP-dependent DNA helicase recG MC28_3079 ENOG4105DP4 dak2 domain fusion protein ylov MC28_3080 ENOG4108ZAA Alkaline-shock protein MC28_3082 ENOG4105FJ0 thiamine MC28_3083 ENOG4105DJV ribulose-phosphate 3-epimerase MC28_3084 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) MC28_3085 ENOG4105D9P serine threonine protein kinase MC28_3086 ENOG4108ZF3 Phosphatase MC28_3088 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B MC28_3089 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) MC28_3091 ENOG4105C25 Primosomal protein n' MC28_3092 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase MC28_3096 ENOG4105DSJ YicC domain protein MC28_3098 ENOG4105F23 Fibronectin-binding protein MC28_3099 ENOG4105DC7 peptidase M24 MC28_3108 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) MC28_3115 ENOG4105C34 Pseudouridine synthase MC28_3120 ENOG4105DBK s4 domain protein MC28_3122 ENOG4105DFA alanine racemase domain protein MC28_3123 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase MC28_3124 ENOG4105WR5 sporulation protein, YlmC YmxH family MC28_3126 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC28_3128 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) MC28_3129 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) MC28_3130 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) MC28_3133 ENOG4105CNI cell division protein FtsW MC28_3136 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) MC28_3137 ENOG4105CJN penicillin-binding protein MC28_3138 ENOG4105CJN penicillin-binding protein MC28_3146 ENOG4105KNH Nucleic acid-binding protein MC28_3154 ENOG4105XSJ toxin secretion phage lysis holin MC28_3173 ENOG4105CAR Terminase, large subunit MC28_3197 ENOG4105KRN Transcriptional regulator, abrb family MC28_3209 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) MC28_3211 ENOG41063PX domain protein MC28_3212 ENOG4105D78 K07001 NTE family protein MC28_3213 ENOG4105H20 Sporulation integral membrane protein YlbJ MC28_3215 ENOG4106H78 methyltransferase MC28_3219 ENOG4107TB6 phosphoglycerate mutase MC28_3222 ENOG4106UY4 Inherit from COG: Scp-like extracellular MC28_3232 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) MC28_3234 ENOG4105CNI cell division protein FtsW MC28_3237 ENOG4108IAB Phoh family MC28_3241 ENOG4105QA2 MC28_3242 ENOG4105CI3 gtp-binding protein typa MC28_3244 ENOG4105ECY inositol monophosphatase MC28_3248 ENOG4105CXN decarboxylase MC28_3255 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MC28_3260 ENOG4105CPP Dehydrogenase, E1 component MC28_3263 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) MC28_3264 ENOG4108X4Q Hydrolase MC28_3266 ENOG4105CN5 Metallo-Beta-Lactamase MC28_3267 ENOG4107ZYR domain protein MC28_3270 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) MC28_3274 ENOG4108XRC Protein of unknown function (DUF458) MC28_3275 ENOG4107IN1 Protein of unknown function (DUF1797) MC28_3279 ENOG4105EPM Diguanylate phosphodiesterase MC28_3280 ENOG4105K6S Short-chain dehydrogenase reductase Sdr MC28_3283 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) MC28_3285 ENOG4105UIN MC28_3297 ENOG4108HGU Histidine kinase MC28_3299 ENOG4105CHM Aminotransferase MC28_3300 ENOG4105FKQ transcriptional regulator MC28_3301 ENOG4105EG2 ABC transporter, permease MC28_3303 ENOG4107FKK extracellular solute-binding protein family 1 MC28_3305 ENOG4105CG3 alpha amylase, catalytic region MC28_3314 ENOG4105CHU acetyl-coa acetyltransferase MC28_3321 ENOG4105K7K Transcriptional regulator MC28_3322 ENOG4105DTD Dehydrogenase MC28_3326 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase MC28_3331 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) MC28_3334 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase MC28_3336 ENOG4105BZU Histidine kinase MC28_3340 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) MC28_3343 ENOG4105CID antiterminator MC28_3345 ENOG4105FDP GntR family transcriptional regulator MC28_3347 ENOG4105CE4 GlcNAc 6-P deacetylase MC28_3353 ENOG4107ZE5 PPIases accelerate the folding of proteins MC28_3354 ENOG4105PTM secreted protein MC28_3355 ENOG4105J7I hydrolase MC28_3357 ENOG4105G6R Stage v sporulation protein ae MC28_3359 ENOG4105CZ3 stage V sporulation protein ad MC28_3360 ENOG41090VF Stage v sporulation protein ac MC28_3364 ENOG4105C8J )-transporter MC28_3365 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC28_3367 ENOG41082AN stage II sporulation protein MC28_3368 ENOG4105DZ1 carboxypeptidase MC28_3369 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family MC28_3370 ENOG4105DVE abc transporter atp-binding protein MC28_3377 ENOG4105D7N magnesium and cobalt transport protein CorA MC28_3382 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MC28_3384 ENOG4105I3K Ferric uptake regulator, Fur family MC28_3385 ENOG4105MZ9 stage II sporulation protein m MC28_3389 ENOG4105CPC Aldo Keto reductase MC28_3390 ENOG4105CV8 reductase MC28_3391 ENOG4105RHY Pfam:UPF0157 MC28_3395 ENOG4107SKW Inherit from COG: Alpha beta hydrolase MC28_3397 ENOG4105ETE Transcriptional regulator (LacI family MC28_3398 ENOG4108YM7 Gcn5-related n-acetyltransferase MC28_3402 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) MC28_3403 ENOG4108R6K riboflavin synthase, subunit alpha MC28_3408 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MC28_3409 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MC28_3412 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) MC28_3414 ENOG4105DFD Na H antiporter MC28_3415 ENOG4105CGH 5'-nucleotidase MC28_3424 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase MC28_3426 ENOG4108IXY short-chain dehydrogenase reductase MC28_3427 ENOG41069FQ Metallo-beta-lactamase superfamily MC28_3428 ENOG4105II7 pyrroline-5-carboxylate reductase MC28_3435 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic MC28_3438 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) MC28_3439 ENOG4105D9U N-acetyltransferase MC28_3441 ENOG4108VZI ErfK ybiS ycfS ynhG family protein MC28_3442 ENOG4108QEG Membrane MC28_3443 ENOG4105CDA abc transporter atp-binding protein MC28_3444 ENOG4105E5Q amino acid AbC transporter MC28_3445 ENOG4108HW3 (ABC) transporter MC28_3447 ENOG4105G7B Protein of unknown function (DUF2992) MC28_3449 ENOG4108QY0 Membrane MC28_3451 ENOG4105C7S Dehydrogenase MC28_3452 ENOG4105CPP Dehydrogenase, E1 component MC28_3456 ENOG4107RDP Dehydrogenase MC28_3458 ENOG4108JUB Transcriptional regulator MC28_3460 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MC28_3464 ENOG4107QQR Sporulation MC28_3465 ENOG4105S1Z Stage IV sporulation protein B MC28_3466 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) MC28_3468 ENOG4105DX0 Hemolysin A MC28_3470 ENOG4105CTB Polyprenyl synthetase MC28_3473 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) MC28_3474 ENOG4105M7K Involved in the transcription termination process (By similarity) MC28_3475 ENOG4108ZSR alkaline shock protein MC28_3476 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase MC28_3481 ENOG410644B Stage III sporulation protein af MC28_3483 ENOG4105KQ4 Stage iii sporulation protein ad MC28_3484 ENOG4108CQH stage III sporulation protein AC MC28_3485 ENOG4105KR5 Stage iii sporulation protein MC28_3486 ENOG4105CD2 stage iii sporulation protein aa MC28_3491 ENOG4105DC7 peptidase M24 MC28_3494 ENOG4105CBJ Metal-dependent enzyme MC28_3496 ENOG4107YBY Hydrolase MC28_3502 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) MC28_3503 ENOG4105WZW rhodanese family MC28_3508 ENOG41080TC multidrug resistance protein MC28_3513 ENOG4105CJ1 ABC, transporter MC28_3514 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family MC28_3517 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor MC28_3519 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) MC28_3520 ENOG4105C0D helicase MC28_3533 ENOG4106855 Competence protein MC28_3538 ENOG4107R6U sodium dicarboxylate symporter MC28_3546 ENOG4105C3R Methionine synthase MC28_3548 ENOG4105C28 cystathionine MC28_3549 ENOG4105C28 cystathionine MC28_3554 ENOG4105C5X domain protein MC28_3556 ENOG4105DKQ ROK family MC28_3558 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase MC28_3560 ENOG4108UTW Plays a role in the regulation of phosphate uptake MC28_3561 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) MC28_3562 ENOG4105E2Z phosphate ABC transporter (Permease MC28_3563 ENOG4105C8U phosphate abc transporter MC28_3564 ENOG4105PWN phosphate abc transporter MC28_3565 ENOG4107RF6 penicillin-binding protein MC28_3567 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MC28_3571 ENOG4105N80 Ferric uptake regulator, Fur family MC28_3573 ENOG4105FDK ABC transporter MC28_3574 ENOG4108JYZ YitT family MC28_3575 ENOG41069ZM Protein of unknown function (DUF2624) MC28_3581 ENOG4105EGD dinuclear metal center protein, YbgI family MC28_3584 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC28_3585 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) MC28_3586 ENOG4107XJU UPF0178 protein MC28_3591 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) MC28_3592 ENOG4105KG3 cytidine deaminase MC28_3593 ENOG4107YR5 Diacylglycerol kinase MC28_3594 ENOG4107YVF Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) MC28_3595 ENOG4105CTJ Metal Dependent Phosphohydrolase MC28_3596 ENOG4105C9A Phoh family MC28_3598 ENOG41068P3 sporulation protein YqfC MC28_3599 ENOG4105KTH gatB Yqey MC28_3601 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) MC28_3602 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) MC28_3604 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MC28_3608 ENOG4105CSA Coproporphyrinogen iii oxidase MC28_3609 ENOG4105KVH Transcriptional regulator MC28_3614 ENOG4105TQK DNA polymerase iii, delta' subunit MC28_3617 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 MC28_3618 ENOG4108UK2 deaminase MC28_3619 ENOG4105KQC Competence protein MC28_3621 ENOG4105DXX methyltransferase MC28_3623 ENOG4108WF2 Metal Dependent Phosphohydrolase MC28_3624 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) MC28_3625 ENOG410812S Rna-binding protein MC28_3627 ENOG4105CQW ribosome biogenesis GTPase YqeH MC28_3628 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase MC28_3631 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC28_3635 ENOG4108TVJ Nitroreductase MC28_3638 ENOG4105G6Z alkaline phosphatase MC28_3640 ENOG4108MUZ hydrolase MC28_3647 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin MC28_3648 ENOG4105MIR Phenylalanine 4-monooxygenase MC28_3650 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase MC28_3658 ENOG4105S6R Iron-hydroxamate transporter permease subunit MC28_3659 ENOG4108V5C ABC transporter MC28_3662 ENOG4108EKI Dehydrogenase MC28_3663 ENOG4105C28 cystathionine MC28_3669 ENOG4107XRG penicillin-binding protein MC28_3672 ENOG4105CFP Peptidase U32 MC28_3673 ENOG4105XYU peptidase (U32 family) MC28_3674 ENOG4108VQJ O-methyltransferase MC28_3675 ENOG4105HHA aminodeoxychorismate lyase MC28_3681 ENOG4105C02 permease MC28_3684 ENOG41060CR MC28_3685 ENOG4105C7H Helicase, RecD TraA family MC28_3687 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) MC28_3688 ENOG4105C3J Cysteine desulfurase MC28_3690 ENOG4105D1H recombination factor protein RarA MC28_3691 ENOG4108VCI transcription factor, rsfa family MC28_3692 ENOG4105CUZ uba thif-type nad fad binding protein MC28_3694 ENOG4105CUT histidyl-tRNA synthetase MC28_3699 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) MC28_3701 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) MC28_3702 ENOG41076HS cation diffusion facilitator family transporter MC28_3703 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) MC28_3705 ENOG4105CKP Polysaccharide Biosynthesis Protein MC28_3706 ENOG4108QG2 Membrane MC28_3708 ENOG4105VIE preprotein translocase, subunit YajC MC28_3709 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) MC28_3711 ENOG41061AI Protein of unknown function (DUF2905) MC28_3712 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) MC28_3713 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) MC28_3714 ENOG4108HUF Transporter MC28_3720 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase MC28_3721 ENOG4108IYU L-aspartate oxidase MC28_3724 ENOG4108RPX mosc domain containing protein MC28_3725 ENOG4105CQC Prephenate dehydratase MC28_3730 ENOG4105EWM Histidine kinase MC28_3735 ENOG4105X36 (ribosomal) protein MC28_3737 ENOG4105C03 ribonuclease MC28_3740 ENOG4107QMS site-determining protein MC28_3743 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) MC28_3744 ENOG4105DFF Rod shape-determining protein mreb MC28_3749 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase MC28_3752 ENOG41068KH stage VI sporulation protein D MC28_3754 ENOG4105D52 delta-aminolevulinic acid dehydratase MC28_3759 ENOG4105K56 Transcriptional regulator MC28_3763 ENOG4108IUQ atp-dependent protease MC28_3768 ENOG4108QCI YvbH-like oligomerisation region MC28_3770 ENOG4105M59 Phosphodiesterase, mj0936 family MC28_3773 ENOG4108XJQ germination protein MC28_3775 ENOG4108PCX Major Facilitator MC28_3777 ENOG4105KBX Transcriptional regulator, TetR family MC28_3779 ENOG4105PFC Transcriptional regulator MC28_3781 ENOG4105DZC cytosine deaminase MC28_3783 ENOG4108JCI Transcriptional regulator MC28_3785 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MC28_3786 ENOG4108Z40 Transcriptional regulator MC28_3787 ENOG4105RHA ABC transporter, permease MC28_3788 ENOG4108IUX (ABC) transporter MC28_3789 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family MC28_3790 ENOG4105ER2 Ompa motb domain protein MC28_3791 ENOG4105E14 MotA TolQ exbB proton channel MC28_3792 ENOG4108VXD carboxy-peptidase MC28_3794 ENOG4105E33 succinate dehydrogenase MC28_3796 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit MC28_3798 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) MC28_3800 ENOG4105C10 Electron transfer flavoprotein MC28_3801 ENOG4105BZJ Electron transfer flavoprotein MC28_3802 ENOG41060WC Enoyl-CoA hydratase MC28_3803 ENOG4107Z3H Transcriptional regulator, TetR family MC28_3804 ENOG4105CEY Amp-dependent synthetase and ligase MC28_3806 ENOG4105J76 Periplasmic binding protein MC28_3807 ENOG4105S6R Iron-hydroxamate transporter permease subunit MC28_3818 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC28_3821 ENOG4105DR4 Methyltransferase MC28_3823 ENOG4105KFN sortase, SrtB family MC28_3824 ENOG4105E0A ABC, transporter MC28_3827 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) MC28_3829 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) MC28_3831 ENOG4105FE9 pseudouridine synthase MC28_3833 ENOG4105DCG PHP domain protein MC28_3839 ENOG4105C5S asparaginyl-tRNA synthetase MC28_3840 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) MC28_3842 ENOG4108RWN rrna methyltransferase MC28_3847 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC28_3848 ENOG4105CW7 secretion protein, HlyD family MC28_3849 ENOG4108JGH Tetr family transcriptional regulator MC28_3850 ENOG4105CN9 Peptidase m42 family protein MC28_3854 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) MC28_3855 ENOG4105C22 threonyL-tRNA synthetase MC28_3856 ENOG4108TDW sporulation protein YtxC MC28_3861 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase MC28_3862 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) MC28_3864 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) MC28_3865 ENOG4105C2M dna polymerase I MC28_3866 ENOG4105BZU Histidine kinase MC28_3867 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC28_3871 ENOG4108HMX isocitrate dehydrogenase (NADP) MC28_3872 ENOG4105BZN citrate synthase MC28_3874 ENOG4108REF Sporulation integral membrane protein ytvi MC28_3876 ENOG4105CA9 Pyruvate kinase MC28_3880 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family MC28_3881 ENOG4105C6K Malic enzyme MC28_3882 ENOG4105C0B DNA polymerase III (alpha subunit) MC28_3883 ENOG4105VV2 MC28_3885 ENOG4105SFS phosphoesterase RecJ domain protein MC28_3891 ENOG4105DC7 peptidase M24 MC28_3898 ENOG41082W1 Cupin 2, conserved barrel domain protein MC28_3902 ENOG4107YZX Universal stress protein MC28_3903 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase MC28_3911 ENOG4108JYZ YitT family MC28_3915 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) MC28_3917 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) MC28_3918 ENOG4105KBJ sporulation protein ytfj MC28_3921 ENOG4105EFZ amidohydrolase MC28_3923 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) MC28_3928 ENOG4106KR7 LysR family Transcriptional regulator MC28_3930 ENOG4105U5Y Transcriptional regulator MC28_3932 ENOG4105C28 cystathionine MC28_3939 ENOG4105EMN RNA polymerase sigma factor MC28_3941 ENOG4108UW5 maltose o-acetyltransferase MC28_3943 ENOG4105F1V Acetoin utilization protein MC28_3944 ENOG4105W87 Cbs domain MC28_3945 ENOG4105DGU Histone deacetylase MC28_3948 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC28_3949 ENOG4105BZU Histidine kinase MC28_3950 ENOG4107SNB ankyrin repeat protein YahD MC28_3951 ENOG4105EP9 oxidoreductase MC28_3956 ENOG4105ETE Transcriptional regulator (LacI family MC28_3961 ENOG4105C88 aminopeptidase MC28_3965 ENOG4108IPJ Membrane MC28_3970 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase MC28_3972 ENOG4108VDD TRNA binding domain protein MC28_3975 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) MC28_3978 ENOG4105C8F Beta-lactamase domain protein MC28_3981 ENOG4108V15 phosphotransferase enzyme family MC28_3982 ENOG4108IUM Glycogen debranching enzyme MC28_3984 ENOG4107QSE Dipeptidase MC28_3985 ENOG4105YW5 deoR family transcriptional regulator MC28_3988 ENOG4105CBX hi0933 family MC28_3994 ENOG4108VJ1 Transcriptional regulator (CarD family MC28_3995 ENOG4107EXU Short-chain dehydrogenase reductase Sdr MC28_3999 ENOG4108ZAF Molybdopterin MC28_4000 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein MC28_4001 ENOG4105CVM Molybdenum cofactor synthesis domain protein MC28_4003 ENOG4105D06 uba thif-type nad fad binding protein MC28_4004 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) MC28_4008 ENOG41085GJ domain protein MC28_4010 ENOG4105DWV Homoserine O-trans-acetylase MC28_4013 ENOG4108B31 Spore germination protein MC28_4019 ENOG4105C8T Leucyl-tRNA synthetase MC28_4020 ENOG410605W Major Facilitator MC28_4021 ENOG4107S91 Sodium hydrogen exchanger MC28_4022 ENOG4105NCW Trka-c domain protein MC28_4030 ENOG4105N5T Radical SAM Protein MC28_4032 ENOG4105CIG ABC transporter MC28_4035 ENOG4105C37 (CBS) domain MC28_4045 ENOG4105E8V Alpha Beta Hydrolase Fold protein MC28_4047 ENOG4105YVM Phosphoesterase, PA-phosphatase related MC28_4048 ENOG4105BZF Glycosyl transferase (Group 1 MC28_4050 ENOG4105EPU Molybdenum cofactor synthesis domain protein MC28_4061 ENOG4105BZU Histidine kinase MC28_4062 ENOG4105BZU Histidine kinase MC28_4065 ENOG4107T7U Sulfatase MC28_4068 ENOG4105D2X ABC transporter substrate-binding protein MC28_4070 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component MC28_4081 ENOG4108V2W Carbonate dehydratase MC28_4082 ENOG4105C4M (Ubiquinol oxidase) subunit I MC28_4083 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii MC28_4091 ENOG41087YS Phage shock protein A MC28_4097 ENOG4105BZU Histidine kinase MC28_4098 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_4103 ENOG4108UGV hypoxanthine phosphoribosyltransferase MC28_4104 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) MC28_4109 ENOG4105C19 ABC transporter MC28_4113 ENOG4107ZTW SNARE associated Golgi MC28_4114 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) MC28_4116 ENOG4105C19 ABC transporter MC28_4117 ENOG41086D8 Transcriptional regulator MC28_4121 ENOG41082BM Transcriptional regulator, arsr family MC28_4124 ENOG4105EMN RNA polymerase sigma factor MC28_4132 ENOG4105C6Z Gluconate MC28_4133 ENOG4105FDP GntR family transcriptional regulator MC28_4137 ENOG41069H0 dihydroorotase EC 3.5.2.3 MC28_4140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_4141 ENOG4105DTQ mandelate racemase muconate lactonizing MC28_4143 ENOG4108IPT Naphthoate synthase MC28_4146 ENOG4105E4F Isochorismate synthase MC28_4147 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase MC28_4149 ENOG4105VEQ Cold shock protein MC28_4156 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) MC28_4159 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin MC28_4160 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MC28_4163 ENOG4105KT7 mgtC SapB transporter MC28_4164 ENOG4107PBV potassium channel MC28_4167 ENOG4105WG9 Conserved Protein MC28_4169 ENOG4105CHM Aminotransferase MC28_4170 ENOG4108ZB6 transcriptional regulator AsnC family MC28_4171 ENOG4105C5I Dehydrogenase MC28_4172 ENOG4108MUZ hydrolase MC28_4174 ENOG4105C87 Aminotransferase class I and II MC28_4177 ENOG4105Y38 Kinase-associated protein B MC28_4180 ENOG4107R3E Citrate transporter MC28_4183 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) MC28_4184 ENOG4105KA0 thioesterase Superfamily protein MC28_4187 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MC28_4191 ENOG41069ER domain protein MC28_4194 ENOG4105CEP NADH dehydrogenase MC28_4199 ENOG4105EWC Purine nucleoside phosphorylase MC28_4203 ENOG4108YX9 iron--sulfur cluster insertion protein erpA MC28_4208 ENOG4105C4B ABC transporter, permease MC28_4209 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA MC28_4218 ENOG4108W5N phosphatidylglycerophosphatase a MC28_4222 ENOG4105DYS nad(p)h dehydrogenase (quinone) MC28_4224 ENOG4105D4U had-superfamily hydrolase, subfamily iia MC28_4227 ENOG4105CBT Fructose-1,6-bisphosphatase MC28_4232 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) MC28_4233 ENOG4107TXC Transcriptional regulator MC28_4234 ENOG41090T1 Membrane MC28_4239 ENOG4105FAA peptidase M23 MC28_4241 ENOG4105KZD Domain of unknown function (DUF1805) MC28_4242 ENOG4107R8B 5'-nucleotidase MC28_4243 ENOG4105DIW FeS assembly protein SUFB MC28_4244 ENOG4108UNV SUF system FeS assembly protein, NifU family MC28_4245 ENOG4105C9B Cysteine desulfurase MC28_4246 ENOG4105JRK feS assembly protein SufD MC28_4247 ENOG4105C3K feS assembly ATPase SufC MC28_4248 ENOG4105D01 (LipO)protein MC28_4249 ENOG4105D01 (LipO)protein MC28_4257 ENOG41080E8 Transcriptional regulator, Spx MgsR family MC28_4265 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MC28_4270 ENOG4108W8B Beta-lactamase domain protein MC28_4271 ENOG4105C1G acyl-Coa dehydrogenase MC28_4273 ENOG4105CHU acetyl-coa acetyltransferase MC28_4276 ENOG4105DZ1 carboxypeptidase MC28_4280 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer MC28_4283 ENOG4108SUT Major Facilitator Superfamily MC28_4284 ENOG4107R7I amino acid MC28_4286 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MC28_4288 ENOG4107AYK membrAne MC28_4294 ENOG4107ZTW SNARE associated Golgi MC28_4296 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein MC28_4297 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_4298 ENOG4105BZU Histidine kinase MC28_4300 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) MC28_4302 ENOG4105C8Q Methyl-accepting chemotaxis MC28_4303 ENOG4105C8Q Methyl-accepting chemotaxis MC28_4304 ENOG4105VG1 fes assembly suf system protein MC28_4305 ENOG4105D4Y metalloprotease MC28_4306 ENOG4105C2I pirin domain protein MC28_4309 ENOG4107T5V SNARE associated Golgi MC28_4310 ENOG4107S91 Sodium hydrogen exchanger MC28_4311 ENOG4105NCW Trka-c domain protein MC28_4313 ENOG4108RMU ferritin dps family protein MC28_4316 ENOG4108URH decarboxylase MC28_4318 ENOG41090A1 ferritin MC28_4319 ENOG4105DHF Membrane MC28_4320 ENOG4105D9N nucleoside MC28_4321 ENOG4105D9N nucleoside MC28_4327 ENOG4105CV8 reductase MC28_4328 ENOG4105F27 Major Facilitator MC28_4329 ENOG4105KVH Transcriptional regulator MC28_4332 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) MC28_4333 ENOG4105D4A Cell wall formation (By similarity) MC28_4335 ENOG4105C8Q Methyl-accepting chemotaxis MC28_4337 ENOG4105WMR Protein CrcB homolog MC28_4338 ENOG4105WMR Protein CrcB homolog MC28_4342 ENOG4105C5H ABC transporter MC28_4343 ENOG4108MK9 spermidine N(1)-acetyltransferase MC28_4344 ENOG4108VY7 phosphate-starvation-inducible protein PsiE MC28_4347 ENOG4108W2Y isochorismatase MC28_4351 ENOG4108V2W Carbonate dehydratase MC28_4352 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) MC28_4355 ENOG4108IPW abc transporter atp-binding protein MC28_4356 ENOG4105CM4 permease protein MC28_4361 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) MC28_4363 ENOG4105XZU Preprotein translocase, subunit SecG MC28_4364 ENOG41067MG lrgb family MC28_4374 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC28_4379 ENOG41090VF Stage v sporulation protein ac MC28_4380 ENOG4105CZ3 stage V sporulation protein ad MC28_4383 ENOG4108QY0 Membrane MC28_4384 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) MC28_4386 ENOG4105KRI phosphocarrier protein (HPr MC28_4388 ENOG4105CHW UPF0052 protein MC28_4389 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) MC28_4390 ENOG4108Z4K mutator MutT protein MC28_4394 ENOG4108S4C acetyltransferase MC28_4399 ENOG41086DT Membrane protein of unknown function MC28_4401 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) MC28_4402 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) MC28_4404 ENOG4107TXC Transcriptional regulator MC28_4407 ENOG4105HMI Membrane MC28_4408 ENOG4105DUM transcriptional regulator, lysR family MC28_4415 ENOG4105CN1 protease MC28_4416 ENOG4105CRP Part of the ABC transporter FtsEX involved in MC28_4417 ENOG4105CAK Cell division ATP-binding protein ftsE MC28_4423 ENOG4105MS2 ribosomal subunit Interface protein MC28_4425 ENOG4105VEQ Cold shock protein MC28_4431 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein MC28_4432 ENOG4108KGH TRANSCRIPTIONal MC28_4433 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase MC28_4434 ENOG4105C6Y Udp-glucose 6-dehydrogenase MC28_4435 ENOG4105ESV Glycosyl transferase, family 4 MC28_4437 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family MC28_4441 ENOG4105F8D glycoside hydrolase family 4 MC28_4442 ENOG4105VCP PTS System MC28_4443 ENOG4105CK1 PTS System MC28_4446 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) MC28_4447 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) MC28_4448 ENOG4105VCP PTS System MC28_4450 ENOG4105VZJ PTS System MC28_4454 ENOG4105ECB domain protein MC28_4455 ENOG4107RSM transcriptional regulator MC28_4462 ENOG4105DAA L-lactate MC28_4464 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) MC28_4466 ENOG4105E0M Sulfatase MC28_4472 ENOG4107R8N Glycosyl transferase, family 2 MC28_4473 ENOG4105C94 Transporter MC28_4475 ENOG41069ER domain protein MC28_4477 ENOG4105KBK Zinc finger, swim domain protein MC28_4478 ENOG4105C0D helicase MC28_4486 ENOG4107RBB ABC transporter, permease MC28_4487 ENOG4105C19 ABC transporter MC28_4489 ENOG4105CXY transporter MC28_4492 ENOG41065SU Two-component system sensor kinase MC28_4493 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_4494 ENOG4105CMR udp-glucose 4-epimerase MC28_4496 ENOG4106MCE EamA-like transporter family MC28_4497 ENOG4108KN0 Choline kinase MC28_4498 ENOG4105KPE licD family MC28_4500 ENOG4108KGH TRANSCRIPTIONal MC28_4502 ENOG4107TAE Glycosyl transferase (Group 1 MC28_4503 ENOG4105K64 Glycosyl transferase, family 2 MC28_4510 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MC28_4511 ENOG4108RB3 Capsular polysaccharide biosynthesis protein MC28_4512 ENOG4107YJ4 chain length determinant protein MC28_4513 ENOG4105HTX biosynthesis protein MC28_4514 ENOG4107YJ4 chain length determinant protein MC28_4517 ENOG4105MT0 Sporulation transcriptional regulator spoiiid MC28_4519 ENOG4105FRN stage II sporulation protein MC28_4522 ENOG4105DY9 regulatoR MC28_4526 ENOG4106778 Protein of unknown function (DUF1146) MC28_4527 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MC28_4528 ENOG4105C8S subunit m MC28_4529 ENOG4105D65 subunit l MC28_4534 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) MC28_4535 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MC28_4537 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain MC28_4538 ENOG4105BZU Histidine kinase MC28_4544 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) MC28_4548 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) MC28_4549 ENOG41062M3 atp synthase MC28_4554 ENOG4108UIC UPF0340 protein MC28_4555 ENOG4108YZG isomerase MC28_4558 ENOG4108VGI doxx family MC28_4559 ENOG4107XC4 flavin reductase domain protein, FMN-binding MC28_4562 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MC28_4564 ENOG4108ZXQ stage ii sporulation protein r MC28_4565 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) MC28_4567 ENOG4107104 thymidine kinase MC28_4568 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) MC28_4569 ENOG4105CBT Fructose-1,6-bisphosphatase MC28_4570 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) MC28_4577 ENOG4105C1G acyl-Coa dehydrogenase MC28_4578 ENOG4105C1G acyl-Coa dehydrogenase MC28_4579 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase MC28_4581 ENOG4105DF6 Fe-S oxidoreductase MC28_4584 ENOG4105BZU Histidine kinase MC28_4587 ENOG4105D4Y metalloprotease MC28_4589 ENOG4105BZU Histidine kinase MC28_4590 ENOG4105KCT ABC transporter MC28_4591 ENOG4108M15 ABC transporter MC28_4592 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) MC28_4594 ENOG4105IIU Aminopeptidase MC28_4599 ENOG410684U Domain of unknown function (DUF1934) MC28_4603 ENOG4105CYW agmatinase MC28_4604 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) MC28_4605 ENOG4105DXB Major Facilitator superfamily MC28_4606 ENOG4107SWG transcriptional regulator MERR family MC28_4607 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MC28_4608 ENOG4105BZ4 penicillin-binding protein MC28_4609 ENOG4108XFG YwhD family MC28_4610 ENOG4108Z4T Peptidase M50 MC28_4611 ENOG41069HH 4-oxalocrotonate tautomerase MC28_4612 ENOG4105DCI Phosphohydrolase MC28_4613 ENOG4108MES Periplasmic binding protein MC28_4614 ENOG4105E0A ABC, transporter MC28_4615 ENOG4105EHG Permease protein MC28_4616 ENOG4105DQ5 transport system permease protein MC28_4618 ENOG4108VCI transcription factor, rsfa family MC28_4619 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) MC28_4620 ENOG4108IJ2 phosphate acetyltransferase MC28_4621 ENOG4107UEZ chlorite dismutase MC28_4623 ENOG4108VKI Cell wall hydrolase MC28_4627 ENOG4107SVH Potassium channel protein MC28_4629 ENOG410667J hydrolase MC28_4630 ENOG4105VCH membrane MC28_4632 ENOG4108TU7 Inherit from COG: (ABC) transporter MC28_4633 ENOG4105CJ1 ABC, transporter MC28_4634 ENOG41090WU lipolytic protein G-D-S-L family MC28_4637 ENOG4105D6E homoserine dehydrogenase MC28_4642 ENOG4108Y4K DNA-binding transcriptional activator MC28_4644 ENOG4105WH1 Two component transcriptional regulator luxr family MC28_4645 ENOG4105BZU Histidine kinase MC28_4646 ENOG4105DWF phosphomethylpyrimidine kinase MC28_4647 ENOG4105BZU Histidine kinase MC28_4648 ENOG4105VCD cytoplasmic protein MC28_4649 ENOG4105D22 carbon starvation protein MC28_4650 ENOG4105DY9 regulatoR MC28_4651 ENOG41079KZ Major Facilitator Superfamily MC28_4654 ENOG4105CG5 Glycosyl transferase (Group 1 MC28_4656 ENOG4105EN6 Membrane MC28_4657 ENOG4106YBV Methyl-accepting chemotaxis MC28_4659 ENOG4108S4H thioesterase Superfamily protein MC28_4663 ENOG4108IG5 Transcriptional regulator MC28_4664 ENOG4105C5H ABC transporter MC28_4667 ENOG4105CKK Glycosyl transferase, family 2 MC28_4668 ENOG41067SE Tetr family transcriptional regulator MC28_4670 ENOG4105E0X reductase MC28_4671 ENOG4106F5Q Membrane MC28_4674 ENOG4108NEV two component transcriptional regulator, LytTR family MC28_4675 ENOG4108HRK Histidine kinase MC28_4676 ENOG4107RGD Major Facilitator superfamily MC28_4679 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) MC28_4681 ENOG4105IW1 AmiS UreI transporter MC28_4683 ENOG4105CMR udp-glucose 4-epimerase MC28_4684 ENOG4108UT2 hemolysin iii MC28_4686 ENOG4105C1J atp-dependent rna helicase MC28_4688 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) MC28_4689 ENOG4105DPN Oligoendopeptidase f MC28_4693 ENOG4105C0H protease MC28_4694 ENOG4105Q2H domain protein MC28_4697 ENOG4105BZU Histidine kinase MC28_4698 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_4699 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis MC28_4700 ENOG4105CDU Replicative dna helicase MC28_4702 ENOG4105BZR domain protein MC28_4703 ENOG4108XMW Membrane MC28_4705 ENOG4108UUM single-stranded DNA-binding protein MC28_4707 ENOG4105C3G gtp-binding protein MC28_4708 ENOG4105VDK protein, conserved in bacteria MC28_4709 ENOG4105D8X mechanosensitive ion channel MC28_4710 ENOG4108ZDA Sporulation protein YyaC MC28_4711 ENOG4105FA0 parb-like partition protein MC28_4712 ENOG4107QJE Chromosome Partitioning Protein MC28_4718 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins MC28_4719 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) MC28_4722 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) MC28_4723 ENOG410848D S4 domain protein YaaA MC28_4726 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) MC28_4728 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) MC28_4734 ENOG4105ZMH deoxynucleoside kinase MC28_4736 ENOG4105GTG Isochorismatase MC28_4737 ENOG4108Z6B deaminase MC28_4738 ENOG4105C6E dna polymerase iii MC28_4742 ENOG41067KS pro-sigma K processing MC28_4744 ENOG4105CXN decarboxylase MC28_4746 ENOG4105FA2 dna polymerase iii MC28_4747 ENOG4105MA4 psp1 domain protein MC28_4749 ENOG41060K3 Methyltransferase MC28_4751 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) MC28_4752 ENOG4105KRN Transcriptional regulator, abrb family MC28_4753 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) MC28_4754 ENOG4105F8V Hydrolase, tatD family MC28_4755 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) MC28_4756 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) MC28_4757 ENOG4105XFA sporulation peptidase YabG MC28_4758 ENOG4105W42 Veg protein MC28_4761 ENOG4105DFT pur operon repressor MC28_4762 ENOG4105KME endoribonuclease L-psp MC28_4765 ENOG4105C5T Phosphoribosyl pyrophosphate synthase MC28_4766 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) MC28_4768 ENOG4108JA2 transcriptioN-repair coupling factor MC28_4769 ENOG4108M14 stage v sporulation protein t MC28_4770 ENOG4108IY2 MazG family MC28_4771 ENOG41082I2 s4 domain protein MC28_4772 ENOG4105VYY sporulation protein yabp MC28_4775 ENOG41060GV RNA binding s1 domain protein MC28_4778 ENOG4108UGV hypoxanthine phosphoribosyltransferase MC28_4779 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) MC28_4782 ENOG4105C6T cysteine synthase MC28_4783 ENOG4105CRQ synthase (Component I) MC28_4784 ENOG4105DDQ anthranilate synthase MC28_4785 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 MC28_4786 ENOG4105EEI dihydropteroate synthase MC28_4787 ENOG4105KRF dihydroneopterin aldolase MC28_4788 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MC28_4789 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) MC28_4792 ENOG4108Z0C Uvrb UvrC protein MC28_4795 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) MC28_4797 ENOG4105CTP PilT protein domain protein MC28_4801 ENOG4105D7W serine acetyltransferase MC28_4804 ENOG4105C2N RNA methyltransferase TrmH family group 3 MC28_4805 ENOG4105M0M Tetracycline resistance protein MC28_4806 ENOG4105QIV RNA polymerase MC28_4808 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) MC28_4810 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) MC28_4812 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) MC28_4813 ENOG4107Y49 methyltransferase MC28_4816 ENOG4105XPM ribosomal protein MC28_4837 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) MC28_4840 ENOG4105VPB 50S ribosomal protein L30 MC28_4842 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) MC28_4844 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) MC28_4846 ENOG41067V7 50S ribosomal protein L36 MC28_4852 ENOG4108JJB ABC transporter MC28_4853 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) MC28_4854 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) MC28_4859 ENOG4105D1F ATP-binding protein MC28_4862 ENOG4108NMV polysaccharide deacetylase MC28_4866 ENOG4105C8B TIGR00159 family MC28_4867 ENOG4107U5W ybbr family MC28_4868 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) MC28_4870 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) MC28_4875 ENOG4108PSK reductase MC28_4877 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) MC28_4878 ENOG4105D01 (LipO)protein MC28_4879 ENOG4105EE1 crotonyl-CoA reductase MC28_4881 ENOG4105IQ5 FAD linked oxidase domain protein MC28_4884 ENOG4105C2C drug resistance transporter, Bcr CflA MC28_4887 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component MC28_4888 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC28_4889 ENOG4105C3U ABC transporter MC28_4894 ENOG4108J59 Extracellular solute-binding protein, family 5 MC28_4895 ENOG4108J59 Extracellular solute-binding protein, family 5 MC28_4898 ENOG4106Z1T Nicotinamide Mononucleotide Transporter MC28_4901 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein MC28_4902 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family MC28_4908 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) MC28_4912 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) MC28_4916 ENOG4105C5H ABC transporter MC28_4918 ENOG4105DEF Extracellular solute-binding protein, family 5 MC28_4920 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component MC28_4921 ENOG4105C3U ABC transporter MC28_4922 ENOG4108JQ7 (ABC) transporter MC28_4923 ENOG410667J hydrolase MC28_4929 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase MC28_4930 ENOG4105ERH Fumarylacetoacetate hydrolase MC28_4932 ENOG4105CUB amino acid MC28_4933 ENOG4108SC4 )-transporter MC28_4934 ENOG4105CPF Cell wall formation (By similarity) MC28_4935 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) MC28_4940 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein MC28_4941 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) MC28_4943 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) MC28_4946 ENOG4105K8N protein family UPF0079, ATPase MC28_4947 ENOG41072GX Peptidase M22 Glycoprotease MC28_4948 ENOG410801F ribosomal-protein-alanine acetyltransferase MC28_4949 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) MC28_4950 ENOG4105C5H ABC transporter MC28_4953 ENOG4108TYN CAAX amino terminal protease family protein MC28_4955 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) MC28_4963 ENOG4106BHR ftsk SpoIIIE family protein MC28_4965 ENOG4106128 DNA-binding helix-turn-helix protein MC28_4968 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) MC28_4970 ENOG4105C7N Xanthine uracil vitamin C permease MC28_4972 ENOG4105BZU Histidine kinase MC28_4974 ENOG4107ZXU DSBA oxidoreductase MC28_4977 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) MC28_4982 ENOG4105SX7 Transporter MC28_4989 ENOG4105DPZ Two component transcriptional regulator (Winged helix family MC28_4995 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) MC28_4997 ENOG4108SHN Glycosyl transferase, family 2 MC28_4999 ENOG4105SX7 Transporter MC28_5003 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit MC28_5004 ENOG4105C83 adenylosuccinate lyase MC28_5006 ENOG4105VR9 phosphoribosylformylglycinamidine synthase MC28_5012 ENOG4108V3E phosphoribosylglycinamide formyltransferase MC28_5013 ENOG4105DC1 bifunctional purine biosynthesis protein purh MC28_5014 ENOG4105C12 Phosphoribosylglycinamide synthetase MC28_5020 ENOG4105C4R Atp-dependent dna helicase MC28_5025 ENOG4108W2Y isochorismatase MC28_5028 ENOG4105D01 (LipO)protein MC28_5032 ENOG410834F Transcriptional regulator MC28_5033 ENOG4107I77 yiaA/B two helix domain MC28_5037 ENOG4105CBD Diacylglycerol kinase MC28_5038 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) MC28_5039 ENOG4108JPW Aminotransferase MC28_5041 ENOG4105C26 Dehydrogenase MC28_5042 ENOG4105KPY Small multidrug resistance protein MC28_5047 ENOG4105D9N nucleoside MC28_5048 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MC28_5050 ENOG4105BZU Histidine kinase MC28_5051 ENOG4108W15 Protein of unknown function (DUF1456) MC28_5054 ENOG4105DTQ mandelate racemase muconate lactonizing MC28_5056 ENOG4105DFD Na H antiporter MC28_5060 ENOG4105D3R alkyl hydroperoxide reductase MC28_5061 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) MC28_5062 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) MC28_5063 ENOG4107W7X Aldolase MC28_5064 ENOG4105EHG Permease protein MC28_5065 ENOG4105DQ5 transport system permease protein MC28_5066 ENOG4108V5C ABC transporter MC28_5070 ENOG4106UIA MC28_5071 ENOG4106UIA MC28_5074 ENOG4105BZU Histidine kinase MC28_5078 ENOG410756H nucleotidyltransferase MC28_5079 ENOG4105D2S major facilitator superfamily MC28_5082 ENOG4105E5Q amino acid AbC transporter MC28_5083 ENOG4105EAB amino acid AbC transporter MC28_5085 ENOG4105C8Q Methyl-accepting chemotaxis MC28_5088 ENOG4105DBV ornithine carbamoyltransferase MC28_5090 ENOG4105C5B carbamate kinase MC28_5093 ENOG4105DNP FAD linked oxidase domain protein MC28_5095 ENOG4105CI1 PTS System MC28_5098 ENOG4105C9U ATP-dependent DNA helicase RecQ MC28_5099 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase MC28_5101 ENOG4105C7B Threonine dehydratase MC28_5102 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter MC28_5106 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component MC28_5114 ENOG41062JF Transcriptional regulator MC28_5117 ENOG4105DEU major facilitator superfamily MC28_5124 ENOG4108N0M stress protein MC28_5125 ENOG4106FN3 tellurium resistance protein MC28_5126 ENOG4106FN3 tellurium resistance protein MC28_5127 ENOG4107TS3 membrane protein, TerC MC28_5128 ENOG4108TTB tellurium resistance protein MC28_5132 ENOG4105KJF protein tyrosine phosphatase MC28_5134 ENOG4107U9T Pfam:Ribonuclease_BN MC28_5135 ENOG4105C59 p-type ATPase MC28_5136 ENOG4108IPJ Membrane MC28_5140 ENOG4107ZTW SNARE associated Golgi MC28_5143 ENOG410606W general stress protein MC28_5144 ENOG4105UPD Calcium Proton MC28_5151 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) MC28_5152 ENOG4105VTR Integrase MC28_5166 ENOG4106CVF DNA replication protein MC28_5208 ENOG4108UVJ appr-1-p processing domain protein MC28_5212 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis MC28_5215 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) MC28_5217 ENOG4108JUB Transcriptional regulator MC28_5219 ENOG4108IQI permease MC28_5224 ENOG4105CSV Glutaminase MC28_5227 ENOG4108A04 Beta-lactamase MC28_5231 ENOG4105CKK Glycosyl transferase, family 2 MC28_5232 ENOG4107QQG Dehydrogenase MC28_5233 ENOG4105C3I Nad-dependent epimerase dehydratase MC28_5234 ENOG4105CKK Glycosyl transferase, family 2 MC28_5235 ENOG4105C6N Formate acetyltransferase MC28_5236 ENOG4105F1A Pyruvate formate-lyase MC28_5241 ENOG4105ECP epimerase MC28_5246 ENOG41067AE Membrane-bound metal-dependent hydrolase MC28_5247 ENOG4105CEN a g-specific adenine glycosylase MC28_5248 ENOG4106BXE MC28_5252 ENOG4105BZ1 (ABC) transporter MC28_5253 ENOG4107NBY Membrane MC28_5254 ENOG4105CBC glutamate synthase MC28_5256 ENOG4108IUW ABC transporter MC28_5260 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen MC28_5261 ENOG4105G5W regulator Fur family MC28_5267 ENOG4108JQC penicillin-binding protein 1A MC28_5268 ENOG4107ZQN disulfide bond MC28_5269 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) MC28_5273 ENOG4105CYN Serine protein kinase MC28_5274 ENOG4106AKX UPF0229 protein MC28_5279 ENOG4105DZ6 Band 7 protein MC28_5281 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism MC28_5282 ENOG4108V9W transcriptional regulatory protein MC28_5283 ENOG4105D4T Citrate transporter MC28_5288 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator MC28_5289 ENOG4108IJ9 (ABC) transporter MC28_5292 ENOG4105BZ7 extracellular solute-binding protein family 1 MC28_5294 ENOG4108STX response regulator MC28_5295 ENOG4105US7 Histidine kinase MC28_5300 ENOG4108MRH transcriptional regulatory protein MC28_5302 ENOG4105C6K Malic enzyme MC28_5304 ENOG4108UZ3 Transporter MC28_5305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family MC28_5307 ENOG4105BZU Histidine kinase MC28_5308 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_5311 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) MC28_5312 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) MC28_5313 ENOG4108JB9 formate dehydrogenase MC28_5318 ENOG4105CUB amino acid MC28_5322 ENOG4105C59 p-type ATPase MC28_5323 ENOG4105DAP Nicotinate phosphoribosyltransferase MC28_5330 ENOG41073R8 VanW family MC28_5331 ENOG4108KGH TRANSCRIPTIONal MC28_5332 ENOG4105D9N nucleoside MC28_5333 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase MC28_5334 ENOG4105C37 (CBS) domain MC28_5335 ENOG4108IJ0 Aspartate ammonia-lyase MC28_5336 ENOG4105DAA L-lactate MC28_5339 ENOG4105DUX Transporter MC28_5340 ENOG4108MES Periplasmic binding protein MC28_5341 ENOG4105DQ5 transport system permease protein MC28_5342 ENOG4108IHU transport system permease protein MC28_5343 ENOG4105E0A ABC, transporter MC28_5344 ENOG4105DMQ Methyltransferase MC28_5345 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MC28_5346 ENOG4105EXW epimerase dehydratase MC28_5348 ENOG4107T89 von Willebrand factor, type A MC28_5349 ENOG4105GMT ATPase associated with various cellular activities aaa_5 MC28_5350 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) MC28_5353 ENOG4105BZU Histidine kinase MC28_5354 ENOG4105D5Q Arginine ornithine antiporter MC28_5355 ENOG4107414 GntR family transcriptional regulator MC28_5356 ENOG4105C5Y PTS System MC28_5357 ENOG4105CG3 alpha amylase, catalytic region MC28_5360 ENOG4105E1K spore germination protein MC28_5361 ENOG4105BZU Histidine kinase MC28_5362 ENOG4105WH1 Two component transcriptional regulator luxr family MC28_5363 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin MC28_5365 ENOG4105CRN Aminoglycoside phosphotransferase MC28_5366 ENOG4105BZG amino acid carrier protein MC28_5367 ENOG4105CDA abc transporter atp-binding protein MC28_5368 ENOG4105CT1 (ABC) transporter MC28_5369 ENOG4105EAD ABC transporter MC28_5370 ENOG4105DRP amino acid AbC transporter MC28_5371 ENOG4108IQI permease MC28_5376 ENOG4105D29 Helix-turn-helix type 11 domain protein MC28_5377 ENOG4105NAE bifunctional deaminase-reductase domain protein MC28_5378 ENOG4105BZU Histidine kinase MC28_5381 ENOG4105CHH sulfate transporter MC28_5382 ENOG41068KF Universal stress protein MC28_5384 ENOG4105CXY transporter MC28_5385 ENOG41067TZ transcriptional regulator, MarR family MC28_5386 ENOG4105C0R drug resistance transporter emrb qaca subfamily MC28_5387 ENOG4105ETE Transcriptional regulator (LacI family MC28_5388 ENOG4108RVA ribokinase MC28_5390 ENOG4105C2J ABC transporter MC28_5391 ENOG4105CNN ABC, transporter MC28_5392 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator MC28_5393 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) MC28_5402 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) MC28_5409 ENOG41069ER domain protein MC28_5410 ENOG4105VZ8 Transcriptional regulator MC28_5411 ENOG4107D63 MC28_5414 ENOG4105DUX Transporter MC28_5419 ENOG4105C85 amino acid MC28_5420 ENOG4105C7N Xanthine uracil vitamin C permease MC28_5427 ENOG4105BZ9 Cytochrome C oxidase, subunit I MC28_5428 ENOG4105E2S oxidase) subunit II MC28_5432 ENOG4106CAD Protein of unknown function (DUF3311) MC28_5433 ENOG4105E1V na solute symporter MC28_5436 ENOG4108NHD germination protein MC28_5438 ENOG4105CE1 Ferrous iron transport protein b MC28_5439 ENOG4105CE1 Ferrous iron transport protein b MC28_5440 ENOG4105CE1 Ferrous iron transport protein b MC28_5441 ENOG4105CVA phosphate MC28_5442 ENOG4105C8U phosphate abc transporter MC28_5443 ENOG4105E2Z phosphate ABC transporter (Permease MC28_B23 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis MC28_B61 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) MC28_B71 ENOG4105IG6 Phage terminase, large subunit MC28_C016 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) MC28_C054 ENOG4105KRN Transcriptional regulator, abrb family MC28_C055 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) MC28_C056 ENOG4105K70 DNA-binding protein MC28_C065 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_C068 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_C077 ENOG4105DG6 mannose-6-phosphate isomerase MC28_C080 ENOG4105DQ6 Transposase MC28_D026 ENOG4105EKQ RNA-directed DNA polymerase MC28_D027 ENOG4105K4H Nlp p60 protein MC28_D048 ENOG4105C9U ATP-dependent DNA helicase RecQ MC28_D059 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) MC28_D062 ENOG4105C79 DNA protecting protein DprA MC28_D068 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) MC28_D072 ENOG4108J59 Extracellular solute-binding protein, family 5 MC28_D078 ENOG4107QJE Chromosome Partitioning Protein MC28_D126 ENOG4105EKQ RNA-directed DNA polymerase MC28_D127 ENOG4105K4H Nlp p60 protein MC28_D148 ENOG4105C9U ATP-dependent DNA helicase RecQ MC28_D158 ENOG410780I phosphoprotein phosphatase activity MC28_D180 ENOG4108J59 Extracellular solute-binding protein, family 5 MC28_E020 ENOG4108IMY Transcriptional regulator MC28_E055 ENOG4107T8Q Glycosyl transferase (Group 1 MC28_E065 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_E066 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) MC28_E068 ENOG4105C6Y Udp-glucose 6-dehydrogenase MC28_E069 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase MC28_E071 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_E079 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_E080 ENOG4106ANW SMI1_KNR4 MC28_E091 ENOG4105E1K spore germination protein MC28_E103 ENOG4107QJE Chromosome Partitioning Protein MC28_E108 ENOG4105EKQ RNA-directed DNA polymerase MC28_E117 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) MC28_E118 ENOG4105KRN Transcriptional regulator, abrb family MC28_E119 ENOG4107Y9U Membrane MC28_E120 ENOG4105C87 Aminotransferase class I and II MC28_E121 ENOG410880H cysteine synthase MC28_E138 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_E158 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C MC28_E169 ENOG4105EKQ RNA-directed DNA polymerase MC28_E182 ENOG4105EKQ RNA-directed DNA polymerase MC28_F012 ENOG4105EKQ RNA-directed DNA polymerase MC28_F046 ENOG4108EKI Dehydrogenase MC28_F049 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) MC28_F050 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase MC28_F054 ENOG4108IFG nitrite reductase, (NAD(P)H) MC28_F055 ENOG4105VCQ rubredoxin MC28_F056 ENOG4105DS0 Transcriptional regulator, Crp Fnr family MC28_F058 ENOG4108QTI )-transporter MC28_F059 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) MC28_F061 ENOG4107R7I amino acid MC28_F063 ENOG4105CUB amino acid MC28_F065 ENOG4107UNZ domain protein MC28_F075 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) MC28_F089 ENOG410645S MarR family Transcriptional regulator MC28_F090 ENOG4108MJ3 acetyltransferase MC28_F093 ENOG4105EA8 2-Nitropropane dioxygenase MC28_F098 ENOG4105NA0 Transcriptional regulator MC28_F106 ENOG4108NNZ chitinase MC28_F111 ENOG4105CMT Dihydroxyacetone kinase MC28_F114 ENOG4105KRI phosphocarrier protein (HPr MC28_F115 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) MC28_F118 ENOG4105C2X Arabinose 5-phosphate isomerase MC28_F119 ENOG4105F8D glycoside hydrolase family 4 MC28_F121 ENOG4105ETZ PTS System MC28_F122 ENOG4105F3R pts system mannose fructose sorbose family iid MC28_F129 ENOG4107RF6 penicillin-binding protein MC28_F130 ENOG4108BUD transposase MC28_F138 ENOG4105D7V transposase MC28_F139 ENOG4105BZU Histidine kinase MC28_F140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_F143 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) MC28_F150 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) MC28_F151 ENOG4105E98 transcriptional regulator DeoR family MC28_F152 ENOG4107WD8 ABC transporter, permease MC28_F169 ENOG4105E1K spore germination protein MC28_F173 ENOG4105CSV Glutaminase MC28_F179 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein MC28_F180 ENOG4105CJ1 ABC, transporter MC28_F181 ENOG4108KYE ABC-2 type transporter MC28_F183 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase MC28_F184 ENOG4105CHR reductase MC28_F185 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) MC28_F186 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) MC28_F189 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) MC28_F190 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) MC28_F191 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) MC28_F192 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase MC28_F194 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase MC28_F199 ENOG4106J6E MC28_F212 ENOG4105CZV ABC transporter MC28_F217 ENOG41082W1 Cupin 2, conserved barrel domain protein MC28_F218 ENOG410874W AraC family transcriptional regulator MC28_F223 ENOG4105C19 ABC transporter MC28_F225 ENOG4105BZU Histidine kinase MC28_F233 ENOG4105DG6 mannose-6-phosphate isomerase MC28_F234 ENOG4105DM4 PTS System MC28_F240 ENOG4105K4H Nlp p60 protein MC28_F241 ENOG4105C7B Threonine dehydratase MC28_F250 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase MC28_F254 ENOG4105CHH sulfate transporter MC28_F257 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA MC28_F258 ENOG4105DJ2 Major Facilitator Superfamily MC28_F259 ENOG4108RPX mosc domain containing protein MC28_F260 ENOG4105C6F GntR Family Transcriptional Regulator MC28_F261 ENOG4107D63 MC28_F262 ENOG4105VZ8 Transcriptional regulator MC28_F267 ENOG4105FB9 CRISPR-associated protein MC28_F274 ENOG41067XF inhibitor MC28_G003 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 MC28_G003 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 MC28_G005 ENOG4105W5Q DNA repair protein (RadC MC28_G006 ENOG4105ETE Transcriptional regulator (LacI family MC28_G007 ENOG4105IE8 Alpha-ketoglutarate permease MC28_G008 ENOG4105CK5 oxidoreductase MC28_G013 ENOG4105D2N Aldolase MC28_G014 ENOG4105DH8 myo-inositol catabolism MC28_G018 ENOG4107JM4 Tetratricopeptide repeat MC28_G025 ENOG4105DUX Transporter MC28_G038 ENOG4105C1B dTDP-glucose 4-6-dehydratase MC28_G039 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase MC28_G040 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) MC28_G052 ENOG4105CEP NADH dehydrogenase MC28_G053 ENOG4105VFE sira family MC28_G061 ENOG4105CEY Amp-dependent synthetase and ligase MC28_G063 ENOG4108IQI permease MC28_G064 ENOG4108J5H Homocysteine s-methyltransferase MC28_G065 ENOG4105D7V transposase MC28_G069 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_G070 ENOG4105BZU Histidine kinase MC28_G073 ENOG41082F9 transcriptional regulator MC28_G077 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) MC28_G079 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) MC28_G082 ENOG4105GZI Transcriptional regulator MC28_G083 ENOG4105F27 Major Facilitator MC28_G085 ENOG4105FQP Beta-lactamase MC28_G090 ENOG4107SCK Monooxygenase MC28_G097 ENOG4107QHE Choloylglycine hydrolase MC28_G100 ENOG41067QW Transcriptional regulator MC28_G102 ENOG4106BHF MC28_G104 ENOG4106E8G MC28_G107 ENOG41067XF inhibitor MC28_G113 ENOG4105ED2 Beta-lactamase MC28_G117 ENOG4107QVI Methyltransferase, type 11 MC28_G118 ENOG4105MZU cell filamentation protein MC28_G130 ENOG4105D7V transposase MC28_G137 ENOG4105BZU Histidine kinase MC28_G142 ENOG4105BZ4 penicillin-binding protein MC28_G149 ENOG4108NGU Transcriptional regulator MC28_G150 ENOG4108IMY Transcriptional regulator MC28_G154 ENOG4105K70 DNA-binding protein MC28_G157 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein MC28_G160 ENOG4107VMI polysaccharide deacetylase MC28_G161 ENOG4105BZU Histidine kinase MC28_G163 ENOG4105W1Y Transcriptional regulator MC28_G165 ENOG4105C19 ABC transporter MC28_G167 ENOG4105EWM Histidine kinase MC28_G171 ENOG4105F6J Alpha beta hydrolase fold MC28_G177 ENOG4105DUM transcriptional regulator, lysR family MC28_G178 ENOG4105DWP Membrane MC28_G182 ENOG4108QXE glycerophosphoryl diester phosphodiesterase MC28_G187 ENOG4105D7V transposase MC28_G190 ENOG4105KD7 acetyltransferase MC28_G192 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) MC28_G193 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) MC28_G194 ENOG4105CYW agmatinase MC28_G196 ENOG4106048 Cupin 2, conserved barrel domain protein MC28_G197 ENOG4108KF3 Electron transport protein SCO1 SenC MC28_G223 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) MC28_G226 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) MC28_G238 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) MC28_G252 ENOG4105CMG Carbohydrate kinase MC28_G254 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) MC28_G266 ENOG4105K4H Nlp p60 protein MC28_G290 ENOG4105BZU Histidine kinase MC28_G291 ENOG4105CK6 Two component transcriptional regulator (Winged helix family MC28_G293 ENOG4105C0H protease MC28_G294 ENOG4107WD8 ABC transporter, permease MC28_G297 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin MC28_G305 ENOG4108IND Tetr family transcriptional regulator MC28_G313 ENOG4107JM4 Tetratricopeptide repeat MC28_G325 ENOG4105D7V transposase MC28_G330 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) MC28_G367 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase MC28_G381 ENOG4105M6F mutator MutT protein MC28_G388 ENOG4105M6F mutator MutT protein MC28_G411 ENOG4105VTR Integrase