locus-tag	class	description
MC28_0001	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MC28_0005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MC28_0007	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_0008	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MC28_0009	COG0352	thiamine-phosphate diphosphorylase activity
MC28_0010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_0011	COG2104	thiamine diphosphate biosynthetic process
MC28_0013	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_0014	COG0351	phosphomethylpyrimidine kinase
MC28_0021	COG2205	protein histidine kinase activity
MC28_0022	COG2814	Major facilitator Superfamily
MC28_0023	COG1846	Transcriptional regulator
MC28_0027	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC28_0028	COG1129	ABC transporter
MC28_0029	COG1879	ABC-type sugar transport system periplasmic component
MC28_0031	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_0042	COG0778	Nitroreductase
MC28_0043	COG2719	SpoVR family
MC28_0048	COG0446	pyridine nucleotide-disulphide oxidoreductase
MC28_0049	COG1937	Protein conserved in bacteria
MC28_0050	COG0425	Belongs to the sulfur carrier protein TusA family
MC28_0050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_0051	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_0051	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_0052	COG0425	Belongs to the sulfur carrier protein TusA family
MC28_0053	COG0425	Belongs to the sulfur carrier protein TusA family
MC28_0053	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_0054	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_0055	COG2210	Belongs to the sulfur carrier protein TusA family
MC28_0056	COG0730	response to heat
MC28_0058	COG1316	TRANSCRIPTIONal
MC28_0059	COG0604	alcohol dehydrogenase
MC28_0060	COG1283	sodium-dependent phosphate transmembrane transporter activity
MC28_0064	COG2814	Major facilitator Superfamily
MC28_0066	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_0066	COG3711	transcriptional antiterminator
MC28_0067	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC28_0068	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC28_0072	COG3584	3D domain protein
MC28_0072	COG1388	LysM domain
MC28_0073	COG0577	efflux transmembrane transporter activity
MC28_0074	COG1136	(ABC) transporter
MC28_0079	COG1114	Component of the transport system for branched-chain amino acids
MC28_0087	COG0586	Pfam SNARE associated Golgi protein
MC28_0094	COG0531	amino acid
MC28_0095	COG0475	glutathione-regulated potassium exporter activity
MC28_0097	COG1737	Transcriptional regulator
MC28_0099	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_0099	COG1263	PTS System
MC28_0101	COG2259	Doxx family
MC28_0106	COG1522	sequence-specific DNA binding
MC28_0112	COG2076	Multidrug Resistance protein
MC28_0113	COG2076	Multidrug Resistance protein
MC28_0114	COG1309	transcriptional regulator
MC28_0115	COG2814	Major facilitator Superfamily
MC28_0116	COG1733	regulation of RNA biosynthetic process
MC28_0118	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_0120	COG4533	DNA binding
MC28_0121	COG2211	Major facilitator Superfamily
MC28_0123	COG0693	protein deglycase activity
MC28_0125	COG0531	amino acid
MC28_0126	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MC28_0127	COG1012	belongs to the aldehyde dehydrogenase family
MC28_0129	COG1132	(ABC) transporter
MC28_0130	COG1132	(ABC) transporter
MC28_0131	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_0132	COG0765	amino acid transport
MC28_0133	COG1126	abc transporter atp-binding protein
MC28_0136	COG0189	ligase activity
MC28_0140	COG0028	Belongs to the TPP enzyme family
MC28_0141	COG3527	Alpha-acetolactate decarboxylase
MC28_0143	COG0561	phosphatase activity
MC28_0145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC28_0148	COG0659	secondary active sulfate transmembrane transporter activity
MC28_0150	COG1024	Enoyl-CoA hydratase
MC28_0154	COG1363	Peptidase, m42
MC28_0160	COG0579	oxidoreductase
MC28_0164	COG0601	transmembrane transport
MC28_0165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC28_0166	COG0444	Belongs to the ABC transporter superfamily
MC28_0167	COG4608	Belongs to the ABC transporter superfamily
MC28_0168	COG5444	nuclease activity
MC28_0177	COG0477	Major facilitator Superfamily
MC28_0178	COG3290	protein histidine kinase activity
MC28_0179	COG4565	transcriptional regulatory protein
MC28_0180	COG3181	Tripartite tricarboxylate transporter family receptor
MC28_0181	COG0494	nUDIX hydrolase
MC28_0185	COG0305	Participates in initiation and elongation during chromosome replication
MC28_0191	COG0477	Major facilitator Superfamily
MC28_0199	COG5632	N-Acetylmuramoyl-L-alanine amidase
MC28_0199	COG3409	Peptidoglycan-binding domain 1 protein
MC28_0201	COG3711	transcriptional antiterminator
MC28_0202	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_0202	COG1263	PTS System
MC28_0202	COG2190	(PTS) system
MC28_0203	COG2723	6-phospho-beta-galactosidase activity
MC28_0205	COG1183	phosphatidylcholine synthase activity
MC28_0211	COG2814	Major facilitator Superfamily
MC28_0217	COG2376	Dihydroxyacetone kinase
MC28_0219	COG2376	Dihydroxyacetone kinase
MC28_0221	COG1959	2 iron, 2 sulfur cluster binding
MC28_0224	COG0745	RESPONSE REGULATOR receiver
MC28_0225	COG5002	protein histidine kinase activity
MC28_0225	COG3850	Histidine kinase
MC28_0232	COG3237	CsbD-like
MC28_0239	COG2208	phosphoserine phosphatase activity
MC28_0240	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MC28_0241	COG0784	Response regulator, receiver
MC28_0241	COG2198	Histidine kinase
MC28_0241	COG2205	protein histidine kinase activity
MC28_0241	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_0254	COG0420	3'-5' exonuclease activity
MC28_0255	COG4717	serine-type aminopeptidase activity
MC28_0259	COG0346	lactoylglutathione lyase activity
MC28_0260	COG0346	lactoylglutathione lyase activity
MC28_0261	COG0457	Tetratricopeptide repeat
MC28_0263	COG2267	carboxylic ester hydrolase activity
MC28_0265	COG3620	sequence-specific DNA binding
MC28_0266	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MC28_0267	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MC28_0269	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MC28_0272	COG0772	Belongs to the SEDS family
MC28_0274	COG3973	AAA domain
MC28_0276	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC28_0280	COG0537	adenosine 5'-monophosphoramidase activity
MC28_0281	COG1131	(ABC) transporter
MC28_0282	COG4473	ABC transporter
MC28_0285	COG1309	transcriptional regulator
MC28_0287	COG3402	PFAM membrane-flanked domain
MC28_0288	COG3428	Bacterial PH domain
MC28_0298	COG3402	PFAM membrane-flanked domain
MC28_0299	COG3428	Bacterial PH domain
MC28_0300	COG2329	Antibiotic biosynthesis monooxygenase
MC28_0301	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_0312	COG1309	transcriptional regulator
MC28_0313	COG1511	domain protein
MC28_0321	COG1609	Transcriptional regulator
MC28_0323	COG1234	tRNA 3'-trailer cleavage
MC28_0324	COG0095	Lipoate-protein ligase
MC28_0326	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_0330	COG1408	metallophosphoesterase
MC28_0332	COG1078	dGTPase activity
MC28_0334	COG1595	DNA-templated transcription, initiation
MC28_0335	COG3708	Transcriptional regulator
MC28_0335	COG2207	Transcriptional regulator
MC28_0337	COG2205	protein histidine kinase activity
MC28_0338	COG0745	RESPONSE REGULATOR receiver
MC28_0344	COG0501	Belongs to the peptidase M48B family
MC28_0345	COG0840	transmembrane signaling receptor activity
MC28_0346	COG0697	spore germination
MC28_0347	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MC28_0348	COG2224	Isocitrate lyase
MC28_0352	COG1278	Cold shock
MC28_0354	COG4903	ComK protein
MC28_0355	COG0398	Pfam SNARE associated Golgi protein
MC28_0359	COG0202	RNA polymerase activity
MC28_0367	COG0179	Fumarylacetoacetate (FAA) hydrolase
MC28_0372	COG0367	asparagine synthase
MC28_0374	COG0753	catalase activity
MC28_0375	COG0004	ammonium transporteR
MC28_0378	COG2996	Protein conserved in bacteria
MC28_0385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_0388	COG0561	phosphatase activity
MC28_0392	COG2267	carboxylic ester hydrolase activity
MC28_0395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_0396	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC28_0397	COG5504	Zn-dependent protease
MC28_0399	COG0180	Tryptophanyl-tRNA synthetase
MC28_0401	COG4166	transmembrane transport
MC28_0402	COG0601	transmembrane transport
MC28_0403	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC28_0405	COG4608	Belongs to the ABC transporter superfamily
MC28_0408	COG0534	Mate efflux family protein
MC28_0409	COG4166	transmembrane transport
MC28_0412	COG1393	Belongs to the ArsC family
MC28_0413	COG0861	Integral membrane protein TerC family
MC28_0415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_0417	COG1164	Oligoendopeptidase f
MC28_0420	COG2346	COG2346, Truncated hemoglobins
MC28_0421	COG4116	CYTH
MC28_0423	COG2357	RelA SpoT domain protein
MC28_0425	COG0564	pseudouridine synthase activity
MC28_0428	COG0772	Belongs to the SEDS family
MC28_0429	COG1216	Glycosyl transferase, family 2
MC28_0434	COG0457	Tetratricopeptide repeat
MC28_0434	COG0463	Glycosyl transferase, family 2
MC28_0441	COG1091	dTDP-4-dehydrorhamnose reductase activity
MC28_0450	COG2153	protein acetylation
MC28_0455	COG5492	domain, Protein
MC28_0456	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC28_0459	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MC28_0459	COG0512	Glutamine amidotransferase of anthranilate synthase
MC28_0466	COG1620	l-lactate permease
MC28_0467	COG5634	Uncharacterized conserved protein (DUF2278)
MC28_0479	COG2226	methyltransferase
MC28_0483	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_0485	COG1476	TRANSCRIPTIONal
MC28_0492	COG4152	abc transporter atp-binding protein
MC28_0493	COG1668	transmembrane transport
MC28_0499	COG0582	viral genome integration into host DNA
MC28_0505	COG1686	Belongs to the peptidase S11 family
MC28_0506	COG0681	Belongs to the peptidase S26 family
MC28_0513	COG1012	belongs to the aldehyde dehydrogenase family
MC28_0517	COG1177	transmembrane transport
MC28_0518	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MC28_0522	COG0564	pseudouridine synthase activity
MC28_0524	COG2340	Cysteine-rich secretory protein family
MC28_0525	COG0247	lactate metabolic process
MC28_0526	COG0277	FAD linked oxidase domain protein
MC28_0527	COG3835	regulator
MC28_0529	COG0745	RESPONSE REGULATOR receiver
MC28_0530	COG5002	protein histidine kinase activity
MC28_0531	COG2186	Transcriptional regulator
MC28_0535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MC28_0537	COG2116	formate transmembrane transporter activity
MC28_0538	COG0861	Integral membrane protein TerC family
MC28_0539	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC28_0541	COG2030	dehydratase
MC28_0545	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_0546	COG3243	poly(R)-hydroxyalkanoic acid synthase
MC28_0548	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC28_0551	COG1840	ABC-type Fe3 transport system, periplasmic component
MC28_0552	COG3842	ATPase activity
MC28_0557	COG1349	DNA-binding transcription factor activity
MC28_0561	COG0235	Class ii aldolase
MC28_0563	COG2861	carbohydrate metabolic process
MC28_0565	COG3852	Histidine kinase
MC28_0566	COG1846	Transcriptional regulator
MC28_0568	COG2318	DinB family
MC28_0570	COG5002	protein histidine kinase activity
MC28_0572	COG0720	synthase
MC28_0578	COG0456	acetyltransferase
MC28_0581	COG1780	Probably involved in ribonucleotide reductase function
MC28_0584	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MC28_0585	COG0531	amino acid
MC28_0586	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MC28_0589	COG2204	response regulator
MC28_0592	COG1725	Transcriptional regulator
MC28_0595	COG1131	(ABC) transporter
MC28_0596	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MC28_0599	COG1522	sequence-specific DNA binding
MC28_0601	COG1335	isochorismatase
MC28_0603	COG1619	proteins homologs of microcin C7 resistance protein MccF
MC28_0604	COG2070	2-Nitropropane dioxygenase
MC28_0605	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MC28_0607	COG1696	Membrane protein involved in D-alanine export
MC28_0612	COG0716	FMN binding
MC28_0619	COG0534	Mate efflux family protein
MC28_0620	COG1968	undecaprenyl-diphosphatase activity
MC28_0624	COG1846	Transcriptional regulator
MC28_0626	COG1301	dicarboxylic acid transport
MC28_0627	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MC28_0628	COG4709	membrane
MC28_0629	COG3874	Sporulation protein YtfJ
MC28_0633	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_0634	COG0028	Belongs to the TPP enzyme family
MC28_0635	COG0440	acetolactate synthase activity
MC28_0650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MC28_0652	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC28_0653	COG1183	phosphatidylcholine synthase activity
MC28_0654	COG1368	sulfuric ester hydrolase activity
MC28_0656	COG0019	diaminopimelate decarboxylase activity
MC28_0660	COG0529	Catalyzes the synthesis of activated sulfate
MC28_0661	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC28_0665	COG1648	precorrin-2 dehydrogenase activity
MC28_0666	COG0733	neurotransmitter:sodium symporter activity
MC28_0671	COG1757	Na H antiporter
MC28_0674	COG4758	membrane
MC28_0675	COG4585	Histidine kinase
MC28_0676	COG2197	response regulator
MC28_0678	COG1114	Component of the transport system for branched-chain amino acids
MC28_0679	COG2226	methyltransferase
MC28_0687	COG0730	response to heat
MC28_0688	COG0306	phosphate transporter
MC28_0689	COG1392	Phosphate transport regulator
MC28_0690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_0693	COG3852	Histidine kinase
MC28_0694	COG1801	Protein of unknown function DUF72
MC28_0696	COG0582	viral genome integration into host DNA
MC28_0697	COG5002	protein histidine kinase activity
MC28_0700	COG0392	lysyltransferase activity
MC28_0700	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MC28_0703	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC28_0704	COG1686	Belongs to the peptidase S11 family
MC28_0705	COG2715	membrane protein required for spore maturation
MC28_0706	COG0700	Nucleoside recognition
MC28_0707	COG1187	pseudouridine synthase activity
MC28_0709	COG1333	cytochrome c biogenesis protein
MC28_0710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC28_0711	COG0745	RESPONSE REGULATOR receiver
MC28_0712	COG5002	protein histidine kinase activity
MC28_0713	COG2096	Adenosyltransferase
MC28_0714	COG4942	peptidase
MC28_0716	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MC28_0717	COG1141	Ferredoxin
MC28_0718	COG4955	Helix-turn-helix domain
MC28_0719	COG0514	ATP-dependent DNA helicase (RecQ)
MC28_0720	COG1266	CAAX protease self-immunity
MC28_0722	COG1408	metallophosphoesterase
MC28_0723	COG0789	Transcriptional regulator
MC28_0724	COG4862	establishment of competence for transformation
MC28_0725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MC28_0729	COG0492	ferredoxin-NADP+ reductase activity
MC28_0743	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MC28_0746	COG0142	geranyltranstransferase activity
MC28_0748	COG0142	geranyltranstransferase activity
MC28_0753	COG0457	Tetratricopeptide repeat
MC28_0758	COG2010	Cytochrome c
MC28_0758	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MC28_0759	COG4347	Protein of unknown function (DUF1405)
MC28_0762	COG2738	Putative neutral zinc metallopeptidase
MC28_0764	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_0765	COG1694	Mazg nucleotide pyrophosphohydrolase
MC28_0768	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MC28_0769	COG0438	transferase activity, transferring glycosyl groups
MC28_0776	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MC28_0776	COG1199	ATP-dependent helicase activity
MC28_0780	COG3935	DnaD domain protein
MC28_0781	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MC28_0783	COG4499	WXG100 protein secretion system (Wss), protein YukC
MC28_0783	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_0794	COG0116	Belongs to the methyltransferase superfamily
MC28_0795	COG4974	Belongs to the 'phage' integrase family
MC28_0809	COG4932	domain protein
MC28_0809	COG4886	Leucine-rich repeat (LRR) protein
MC28_0815	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MC28_0817	COG3173	Aminoglycoside phosphotransferase
MC28_0818	COG0024	Methionine aminopeptidase
MC28_0821	COG2233	PERMEase
MC28_0822	COG2311	Membrane
MC28_0823	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MC28_0825	COG0456	acetyltransferase
MC28_0832	COG0754	glutathionylspermidine amidase activity
MC28_0835	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC28_0838	COG0454	-acetyltransferase
MC28_0842	COG0328	RNA-DNA hybrid ribonuclease activity
MC28_0849	COG3403	YqcI/YcgG family
MC28_0850	COG1280	lysine exporter protein (LysE YggA)
MC28_0853	COG3162	membrane
MC28_0854	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC28_0855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_0857	COG0475	glutathione-regulated potassium exporter activity
MC28_0858	COG0789	Transcriptional regulator
MC28_0858	COG4978	Transcriptional regulator
MC28_0860	COG2323	membrane
MC28_0873	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC28_0874	COG1360	Flagellar Motor Protein
MC28_0876	COG0643	Histidine kinase
MC28_0876	COG2198	Histidine kinase
MC28_0877	COG1776	CheC inhibitor of MCP methylation
MC28_0877	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_0880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MC28_0884	COG1256	bacterial-type flagellum assembly
MC28_0885	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC28_0889	COG1815	bacterial-type flagellum-dependent cell motility
MC28_0890	COG1558	bacterial-type flagellum-dependent cell motility
MC28_0891	COG1677	Flagellar hook-basal body complex protein FliE
MC28_0892	COG1766	The M ring may be actively involved in energy transduction
MC28_0893	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_0895	COG1157	protein secretion by the type III secretion system
MC28_0899	COG1749	Flagellar hook protein flgE
MC28_0902	COG0835	chemotaxis
MC28_0902	COG0784	Response regulator, receiver
MC28_0904	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC28_0905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MC28_0906	COG0741	lytic transglycosylase activity
MC28_0908	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_0909	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MC28_0909	COG1776	CheC inhibitor of MCP methylation
MC28_0911	COG1338	Plays a role in the flagellum-specific transport system
MC28_0912	COG1987	bacterial-type flagellum assembly
MC28_0914	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MC28_0915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MC28_0916	COG1419	protein localization to endoplasmic reticulum
MC28_0917	COG4786	Flagellar basal body rod
MC28_0925	COG2329	Antibiotic biosynthesis monooxygenase
MC28_0928	COG2814	Major facilitator Superfamily
MC28_0931	COG3842	ATPase activity
MC28_0932	COG1840	ABC-type Fe3 transport system, periplasmic component
MC28_0933	COG1177	transmembrane transport
MC28_0941	COG0406	alpha-ribazole phosphatase activity
MC28_0945	COG1846	Transcriptional regulator
MC28_0947	COG0367	asparagine synthase
MC28_0953	COG1802	Transcriptional regulator
MC28_0954	COG0697	spore germination
MC28_0956	COG0523	cobalamin synthesis protein
MC28_0957	COG0701	Predicted permease
MC28_0959	COG1216	Glycosyl transferase, family 2
MC28_0959	COG0438	transferase activity, transferring glycosyl groups
MC28_0960	COG1757	Na H antiporter
MC28_0961	COG0789	Transcriptional regulator
MC28_0962	COG4221	oxidoreductase activity
MC28_0967	COG0534	Mate efflux family protein
MC28_0968	COG3340	Belongs to the peptidase S51 family
MC28_0972	COG0785	Cytochrome C biogenesis protein
MC28_0973	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_0977	COG2733	membrane
MC28_0984	COG1131	(ABC) transporter
MC28_0987	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_0988	COG0528	UMP kinase activity
MC28_0990	COG1027	Aspartate ammonia-lyase
MC28_0991	COG0281	malic enzyme
MC28_0992	COG4191	Histidine kinase
MC28_0993	COG0784	Response regulator, receiver
MC28_0994	COG1846	Transcriptional regulator
MC28_0996	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC28_1000	COG3620	sequence-specific DNA binding
MC28_1013	COG0477	Major facilitator Superfamily
MC28_1014	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_1016	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MC28_1017	COG2223	nitrite transmembrane transporter activity
MC28_1018	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC28_1021	COG2244	polysaccharide biosynthetic process
MC28_1022	COG0733	neurotransmitter:sodium symporter activity
MC28_1024	COG5566	PFAM Mor transcription activator
MC28_1025	COG2323	membrane
MC28_1029	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC28_1031	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_1032	COG0028	Belongs to the TPP enzyme family
MC28_1036	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MC28_1040	COG2814	Major facilitator Superfamily
MC28_1041	COG3384	dioxygenase
MC28_1043	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC28_1047	COG4166	transmembrane transport
MC28_1049	COG0535	radical SAM domain protein
MC28_1050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_1054	COG1914	H( )-stimulated, divalent metal cation uptake system
MC28_1057	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MC28_1059	COG0531	amino acid
MC28_1063	COG1280	lysine exporter protein (LysE YggA)
MC28_1064	COG2390	Transcriptional regulator
MC28_1066	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_1067	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MC28_1068	COG0295	cytidine deaminase activity
MC28_1070	COG4846	Membrane protein involved in cytochrome C biogenesis
MC28_1074	COG0583	DNA-binding transcription factor activity
MC28_1077	COG0006	proline dipeptidase activity
MC28_1078	COG2132	Multicopper oxidase
MC28_1079	COG4193	domain, Protein
MC28_1080	COG1073	alpha beta
MC28_1088	COG1760	l-serine dehydratase
MC28_1090	COG0814	amino acid
MC28_1092	COG1136	(ABC) transporter
MC28_1093	COG0577	efflux transmembrane transporter activity
MC28_1094	COG0745	RESPONSE REGULATOR receiver
MC28_1095	COG2205	protein histidine kinase activity
MC28_1097	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MC28_1100	COG0772	Belongs to the SEDS family
MC28_1101	COG2239	Acts as a magnesium transporter
MC28_1107	COG1073	alpha beta
MC28_1115	COG0583	DNA-binding transcription factor activity
MC28_1119	COG1114	Component of the transport system for branched-chain amino acids
MC28_1121	COG1276	copper resistance
MC28_1121	COG2372	response to copper ion
MC28_1122	COG4549	nuclear export factor GLE1
MC28_1123	COG0697	spore germination
MC28_1124	COG0583	DNA-binding transcription factor activity
MC28_1125	COG1959	2 iron, 2 sulfur cluster binding
MC28_1126	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MC28_1127	COG0778	Nitroreductase
MC28_1130	COG0628	permease
MC28_1134	COG1231	oxidoreductase activity
MC28_1135	COG0523	cobalamin synthesis protein
MC28_1137	COG0411	ABC transporter
MC28_1139	COG0559	Belongs to the binding-protein-dependent transport system permease family
MC28_1141	COG0583	DNA-binding transcription factor activity
MC28_1147	COG1271	oxidase subunit
MC28_1148	COG1294	oxidase, subunit
MC28_1151	COG0463	Glycosyl transferase, family 2
MC28_1155	COG1686	Belongs to the peptidase S11 family
MC28_1158	COG1388	LysM domain
MC28_1158	COG0791	NLP P60 protein
MC28_1161	COG0745	RESPONSE REGULATOR receiver
MC28_1162	COG5002	protein histidine kinase activity
MC28_1164	COG0300	oxidoreductase activity
MC28_1167	COG0726	polysaccharide deacetylase
MC28_1168	COG5658	integral membrane protein
MC28_1171	COG0460	homoserine dehydrogenase
MC28_1176	COG1316	TRANSCRIPTIONal
MC28_1178	COG0745	RESPONSE REGULATOR receiver
MC28_1179	COG5002	protein histidine kinase activity
MC28_1180	COG0726	polysaccharide deacetylase
MC28_1182	COG1285	pathogenesis
MC28_1183	COG1247	-acetyltransferase
MC28_1185	COG4264	IucA IucC family
MC28_1186	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_1189	COG1082	Xylose isomerase domain protein TIM barrel
MC28_1191	COG2814	Major facilitator Superfamily
MC28_1192	COG1279	arginine transmembrane transporter activity
MC28_1193	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_1195	COG1752	Esterase of the alpha-beta hydrolase superfamily
MC28_1215	COG4695	Portal protein
MC28_1222	COG0577	efflux transmembrane transporter activity
MC28_1223	COG2002	toxin-antitoxin pair type II binding
MC28_1224	COG1404	Belongs to the peptidase S8 family
MC28_1225	COG0640	Transcriptional regulator
MC28_1226	COG0667	Aldo Keto reductase
MC28_1234	COG3949	Membrane
MC28_1235	COG0783	Belongs to the Dps family
MC28_1238	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MC28_1240	COG1231	oxidoreductase activity
MC28_1241	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_1242	COG4989	oxidoreductase activity
MC28_1243	COG0523	cobalamin synthesis protein
MC28_1245	COG0803	Belongs to the bacterial solute-binding protein 9 family
MC28_1249	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MC28_1251	COG4166	transmembrane transport
MC28_1257	COG1051	belongs to the nudix hydrolase family
MC28_1258	COG0586	Pfam SNARE associated Golgi protein
MC28_1259	COG2244	polysaccharide biosynthetic process
MC28_1261	COG0701	Predicted permease
MC28_1262	COG3689	TIGRFAM TIGR03943 family protein
MC28_1263	COG1607	acyl-coa hydrolase
MC28_1264	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_1267	COG0702	epimerase
MC28_1268	COG2839	Protein conserved in bacteria
MC28_1269	COG1253	flavin adenine dinucleotide binding
MC28_1274	COG1114	Component of the transport system for branched-chain amino acids
MC28_1275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC28_1278	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_1280	COG1876	peptidase activity
MC28_1282	COG0154	amidase activity
MC28_1283	COG2211	Major facilitator Superfamily
MC28_1286	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_1288	COG0561	phosphatase activity
MC28_1289	COG1846	Transcriptional regulator
MC28_1290	COG2814	Major facilitator Superfamily
MC28_1291	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MC28_1294	COG1819	glycosyl
MC28_1295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_1296	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_1301	COG0456	acetyltransferase
MC28_1305	COG1511	domain protein
MC28_1305	COG0842	Transport permease protein
MC28_1317	COG3874	Sporulation protein YtfJ
MC28_1322	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC28_1326	COG0346	lactoylglutathione lyase activity
MC28_1333	COG0426	domain, Protein
MC28_1333	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MC28_1336	COG1305	Transglutaminase-like
MC28_1337	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MC28_1338	COG0714	Associated with various cellular activities
MC28_1340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MC28_1341	COG1140	nitrate reductase beta subunit
MC28_1342	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MC28_1343	COG2181	nitrate reductase activity
MC28_1344	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC28_1345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MC28_1346	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_1347	COG0303	'Molybdopterin
MC28_1348	COG0314	molybdopterin synthase activity
MC28_1350	COG2223	nitrite transmembrane transporter activity
MC28_1352	COG1648	precorrin-2 dehydrogenase activity
MC28_1354	COG1587	Uroporphyrinogen-III synthase
MC28_1354	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MC28_1355	COG2146	nitrite reductase [NAD(P)H] activity
MC28_1356	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC28_1357	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
MC28_1364	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_1372	COG2359	stage V sporulation protein S
MC28_1374	COG1418	mRNA catabolic process
MC28_1375	COG0488	(ABC) transporter
MC28_1381	COG1413	lyase activity
MC28_1384	COG2136	Putative SAM-dependent methyltransferase
MC28_1384	COG2521	methyltransferase
MC28_1385	COG0018	arginyl-trna synthetase
MC28_1390	COG1309	transcriptional regulator
MC28_1393	COG0017	Asparaginyl-tRNA synthetase
MC28_1394	COG0733	neurotransmitter:sodium symporter activity
MC28_1395	COG2267	carboxylic ester hydrolase activity
MC28_1399	COG2610	gluconate transmembrane transporter activity
MC28_1401	COG1794	racemase activity, acting on amino acids and derivatives
MC28_1403	COG0456	acetyltransferase
MC28_1404	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
MC28_1407	COG0546	phosphoglycolate phosphatase activity
MC28_1410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_1414	COG0768	penicillin binding
MC28_1416	COG0204	Acyl-transferase
MC28_1417	COG1272	protein, Hemolysin III
MC28_1419	COG0805	protein transport
MC28_1421	COG1307	EDD domain protein, DegV family
MC28_1422	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MC28_1423	COG1999	signal sequence binding
MC28_1424	COG0071	Belongs to the small heat shock protein (HSP20) family
MC28_1425	COG0367	asparagine synthase
MC28_1428	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_1429	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_1430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_1433	COG1335	isochorismatase
MC28_1434	COG1051	belongs to the nudix hydrolase family
MC28_1435	COG0668	transmembrane transport
MC28_1436	COG2203	Gaf domain
MC28_1436	COG4585	Histidine kinase
MC28_1437	COG2197	response regulator
MC28_1438	COG1737	Transcriptional regulator
MC28_1439	COG1064	alcohol dehydrogenase
MC28_1451	COG0517	IMP dehydrogenase activity
MC28_1451	COG1125	glycine betaine transport
MC28_1452	COG1174	glycine betaine transport
MC28_1459	COG1253	flavin adenine dinucleotide binding
MC28_1460	COG1012	belongs to the aldehyde dehydrogenase family
MC28_1461	COG5506	Protein of unknown function (DUF1694)
MC28_1464	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_1465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MC28_1467	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC28_1468	COG0456	acetyltransferase
MC28_1470	COG1509	lysine 2,3-aminomutase activity
MC28_1477	COG0515	serine threonine protein kinase
MC28_1477	COG4991	sh3 domain protein
MC28_1477	COG3064	Membrane
MC28_1479	COG0671	phosphoesterase, PA-phosphatase related
MC28_1480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MC28_1483	COG0582	viral genome integration into host DNA
MC28_1492	COG1396	sequence-specific DNA binding
MC28_1498	COG5377	YqaJ viral recombinase family
MC28_1499	COG3723	Recombinational DNA repair protein, rece pathway
MC28_1545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MC28_1551	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_1554	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_1554	COG4499	WXG100 protein secretion system (Wss), protein YukC
MC28_1555	COG2814	Major facilitator Superfamily
MC28_1557	COG0372	Belongs to the citrate synthase family
MC28_1558	COG2079	MmgE PrpD family protein
MC28_1559	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MC28_1560	COG1960	acyl-CoA dehydrogenase activity
MC28_1561	COG2084	Dehydrogenase
MC28_1563	COG1280	lysine exporter protein (LysE YggA)
MC28_1564	COG1024	Enoyl-CoA hydratase
MC28_1567	COG0420	3'-5' exonuclease activity
MC28_1573	COG2223	nitrite transmembrane transporter activity
MC28_1574	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_1575	COG1169	isochorismate synthase
MC28_1576	COG1021	2,3-dihydroxybenzoate-AMP ligase
MC28_1577	COG3433	isochorismatase activity
MC28_1577	COG1535	isochorismatase
MC28_1578	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MC28_1579	COG3251	PFAM MbtH domain protein
MC28_1580	COG2814	Major facilitator Superfamily
MC28_1583	COG0776	regulation of translation
MC28_1585	COG2318	DinB family
MC28_1587	COG1115	amino acid carrier protein
MC28_1589	COG2329	Antibiotic biosynthesis monooxygenase
MC28_1590	COG1187	pseudouridine synthase activity
MC28_1591	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MC28_1592	COG1136	(ABC) transporter
MC28_1594	COG0596	Alpha beta hydrolase
MC28_1598	COG0028	Belongs to the TPP enzyme family
MC28_1605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC28_1607	COG2207	Transcriptional regulator
MC28_1613	COG2755	lipolytic protein G-D-S-L family
MC28_1613	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MC28_1616	COG5002	protein histidine kinase activity
MC28_1618	COG0745	RESPONSE REGULATOR receiver
MC28_1622	COG1846	Transcriptional regulator
MC28_1625	COG1309	transcriptional regulator
MC28_1630	COG1247	-acetyltransferase
MC28_1637	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_1643	COG0583	DNA-binding transcription factor activity
MC28_1644	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC28_1645	COG0583	DNA-binding transcription factor activity
MC28_1646	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MC28_1647	COG2258	MOSC domain
MC28_1653	COG1396	sequence-specific DNA binding
MC28_1662	COG1595	DNA-templated transcription, initiation
MC28_1667	COG1649	PFAM Uncharacterised BCR, COG1649
MC28_1671	COG2971	BadF BadG BcrA BcrD
MC28_1677	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_1683	COG2226	methyltransferase
MC28_1684	COG3961	Belongs to the TPP enzyme family
MC28_1691	COG2195	Cleaves the N-terminal amino acid of tripeptides
MC28_1698	COG2002	toxin-antitoxin pair type II binding
MC28_1700	COG0730	response to heat
MC28_1701	COG0110	maltose O-acetyltransferase activity
MC28_1702	COG1686	Belongs to the peptidase S11 family
MC28_1706	COG0768	penicillin binding
MC28_1707	COG1595	DNA-templated transcription, initiation
MC28_1718	COG0697	spore germination
MC28_1720	COG3397	chitin binding
MC28_1721	COG0823	Involved in the tonB-independent uptake of proteins
MC28_1723	COG1408	metallophosphoesterase
MC28_1725	COG1131	(ABC) transporter
MC28_1727	COG1309	transcriptional regulator
MC28_1729	COG1960	acyl-CoA dehydrogenase activity
MC28_1731	COG0511	ligase activity, forming carbon-carbon bonds
MC28_1733	COG1024	Enoyl-CoA hydratase
MC28_1734	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MC28_1735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC28_1749	COG2318	DinB family
MC28_1750	COG1686	Belongs to the peptidase S11 family
MC28_1756	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC28_1759	COG3227	Zinc metalloprotease (Elastase)
MC28_1760	COG2207	Transcriptional regulator
MC28_1767	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MC28_1773	COG1733	regulation of RNA biosynthetic process
MC28_1774	COG2226	methyltransferase
MC28_1780	COG0697	spore germination
MC28_1781	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_1787	COG0693	protein deglycase activity
MC28_1789	COG3386	PFAM SMP-30 Gluconolaconase
MC28_1790	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
MC28_1791	COG3773	Cell wall hydrolase
MC28_1793	COG0745	RESPONSE REGULATOR receiver
MC28_1794	COG2205	protein histidine kinase activity
MC28_1797	COG0583	DNA-binding transcription factor activity
MC28_1798	COG0667	Aldo Keto reductase
MC28_1801	COG1136	(ABC) transporter
MC28_1802	COG0577	efflux transmembrane transporter activity
MC28_1806	COG0460	homoserine dehydrogenase
MC28_1807	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_1809	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MC28_1830	COG2124	cytochrome p450
MC28_1837	COG0561	phosphatase activity
MC28_1838	COG5002	protein histidine kinase activity
MC28_1841	COG1819	glycosyl
MC28_1842	COG1794	racemase activity, acting on amino acids and derivatives
MC28_1847	COG2205	protein histidine kinase activity
MC28_1850	COG0604	alcohol dehydrogenase
MC28_1851	COG0671	phosphoesterase, PA-phosphatase related
MC28_1864	COG2814	Major facilitator Superfamily
MC28_1868	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_1872	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_1873	COG0697	spore germination
MC28_1881	COG2223	nitrite transmembrane transporter activity
MC28_1883	COG2816	NAD+ diphosphatase activity
MC28_1884	COG0592	DNA-directed DNA polymerase activity
MC28_1892	COG3878	Protein conserved in bacteria
MC28_1897	COG4667	esterase of the alpha-beta hydrolase superfamily
MC28_1905	COG0322	excinuclease ABC activity
MC28_1911	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_1918	COG0745	RESPONSE REGULATOR receiver
MC28_1919	COG5002	protein histidine kinase activity
MC28_1924	COG1136	(ABC) transporter
MC28_1925	COG0577	efflux transmembrane transporter activity
MC28_1927	COG1073	alpha beta
MC28_1929	COG1523	belongs to the glycosyl hydrolase 13 family
MC28_1930	COG3227	Zinc metalloprotease (Elastase)
MC28_1931	COG0737	Belongs to the 5'-nucleotidase family
MC28_1934	COG0201	protein transport
MC28_1935	COG0697	spore germination
MC28_1936	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_1943	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_1946	COG2959	enzyme of heme biosynthesis
MC28_1947	COG3409	Peptidoglycan-binding domain 1 protein
MC28_1947	COG3773	Cell wall hydrolase
MC28_1954	COG1309	transcriptional regulator
MC28_1956	COG3284	Transcriptional regulator
MC28_1960	COG1349	DNA-binding transcription factor activity
MC28_1964	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC28_1965	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_1966	COG0022	dehydrogenase e1 component
MC28_1969	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_1975	COG4176	ABC-type proline glycine betaine transport system permease component
MC28_1976	COG4175	Glycine betaine
MC28_1976	COG0517	IMP dehydrogenase activity
MC28_1982	COG2153	protein acetylation
MC28_1985	COG3397	chitin binding
MC28_1987	COG1819	glycosyl
MC28_1991	COG2205	protein histidine kinase activity
MC28_1992	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MC28_1993	COG2315	Protein conserved in bacteria
MC28_2003	COG3973	AAA domain
MC28_2005	COG0514	ATP-dependent DNA helicase (RecQ)
MC28_2010	COG4637	Psort location Cytoplasmic, score
MC28_2013	COG3397	chitin binding
MC28_2014	COG2318	DinB family
MC28_2018	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MC28_2019	COG1115	amino acid carrier protein
MC28_2020	COG1012	belongs to the aldehyde dehydrogenase family
MC28_2021	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MC28_2022	COG3938	Belongs to the proline racemase family
MC28_2023	COG3938	Belongs to the proline racemase family
MC28_2024	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_2034	COG1078	dGTPase activity
MC28_2035	COG0586	Pfam SNARE associated Golgi protein
MC28_2036	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MC28_2037	COG4166	transmembrane transport
MC28_2039	COG4948	Mandelate Racemase Muconate Lactonizing
MC28_2048	COG2936	dipeptidyl-peptidase activity
MC28_2049	COG5002	protein histidine kinase activity
MC28_2049	COG3850	Histidine kinase
MC28_2055	COG1164	Oligoendopeptidase f
MC28_2056	COG0456	acetyltransferase
MC28_2057	COG1307	EDD domain protein, DegV family
MC28_2067	COG2814	Major facilitator Superfamily
MC28_2069	COG1664	Polymer-forming cytoskeletal
MC28_2070	COG0789	Transcriptional regulator
MC28_2071	COG4533	DNA binding
MC28_2072	COG0477	Major facilitator Superfamily
MC28_2072	COG2814	Major facilitator Superfamily
MC28_2077	COG2261	transglycosylase associated protein
MC28_2080	COG2226	methyltransferase
MC28_2087	COG0436	Aminotransferase
MC28_2088	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MC28_2093	COG1131	(ABC) transporter
MC28_2102	COG0628	permease
MC28_2104	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MC28_2105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_2106	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MC28_2112	COG2746	aminoglycoside 3-N-acetyltransferase activity
MC28_2118	COG0697	spore germination
MC28_2119	COG2318	DinB family
MC28_2126	COG0346	lactoylglutathione lyase activity
MC28_2127	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_2129	COG0726	polysaccharide deacetylase
MC28_2132	COG2814	Major facilitator Superfamily
MC28_2133	COG0861	Integral membrane protein TerC family
MC28_2134	COG1368	sulfuric ester hydrolase activity
MC28_2135	COG0488	(ABC) transporter
MC28_2136	COG1033	growth of symbiont in host cell
MC28_2136	COG2409	Drug exporters of the RND superfamily
MC28_2137	COG1309	transcriptional regulator
MC28_2140	COG0287	Prephenate dehydrogenase
MC28_2143	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MC28_2143	COG1605	Chorismate mutase
MC28_2151	COG3584	3D domain protein
MC28_2151	COG1388	LysM domain
MC28_2153	COG0346	lactoylglutathione lyase activity
MC28_2154	COG0519	Catalyzes the synthesis of GMP from XMP
MC28_2155	COG0431	NADPH-dependent FMN reductase
MC28_2162	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC28_2164	COG2390	Transcriptional regulator
MC28_2165	COG1070	Carbohydrate kinase
MC28_2172	COG2329	Antibiotic biosynthesis monooxygenase
MC28_2177	COG2207	Transcriptional regulator
MC28_2178	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_2181	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC28_2182	COG4187	Peptidase family M20/M25/M40
MC28_2183	COG1414	Transcriptional regulator
MC28_2185	COG0833	amino acid
MC28_2187	COG3239	Fatty acid desaturase
MC28_2189	COG1785	Belongs to the alkaline phosphatase family
MC28_2191	COG3655	Transcriptional regulator
MC28_2196	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_2197	COG0346	lactoylglutathione lyase activity
MC28_2201	COG0714	Associated with various cellular activities
MC28_2206	COG0753	catalase activity
MC28_2214	COG0714	Associated with various cellular activities
MC28_2217	COG5444	nuclease activity
MC28_2224	COG0778	Nitroreductase
MC28_2225	COG1846	Transcriptional regulator
MC28_2229	COG2312	Erythromycin esterase
MC28_2230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC28_2233	COG4977	sequence-specific DNA binding
MC28_2234	COG0456	acetyltransferase
MC28_2238	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_2242	COG0642	Histidine kinase
MC28_2243	COG0745	RESPONSE REGULATOR receiver
MC28_2244	COG0596	Alpha beta hydrolase
MC28_2250	COG0730	response to heat
MC28_2252	COG0833	amino acid
MC28_2254	COG4335	DNA alkylation repair
MC28_2267	COG1984	allophanate hydrolase subunit 2
MC28_2269	COG1414	Transcriptional regulator
MC28_2274	COG0640	Transcriptional regulator
MC28_2276	COG1960	acyl-CoA dehydrogenase activity
MC28_2290	COG3848	Pyruvate phosphate dikinase
MC28_2290	COG0574	Belongs to the PEP-utilizing enzyme family
MC28_2293	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC28_2298	COG0737	Belongs to the 5'-nucleotidase family
MC28_2299	COG2267	carboxylic ester hydrolase activity
MC28_2300	COG1335	isochorismatase
MC28_2304	COG0583	DNA-binding transcription factor activity
MC28_2305	COG0598	Magnesium transport protein CorA
MC28_2313	COG0415	Belongs to the DNA photolyase family
MC28_2320	COG0697	spore germination
MC28_2322	COG1575	Belongs to the MenA family. Type 1 subfamily
MC28_2328	COG0798	PFAM Bile acid sodium symporter
MC28_2329	COG0346	lactoylglutathione lyase activity
MC28_2330	COG0640	Transcriptional regulator
MC28_2337	COG2186	Transcriptional regulator
MC28_2340	COG0814	amino acid
MC28_2341	COG0697	spore germination
MC28_2343	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_2344	COG1522	sequence-specific DNA binding
MC28_2347	COG0346	lactoylglutathione lyase activity
MC28_2360	COG0384	phenazine biosynthesis protein PhzF
MC28_2362	COG2814	Major facilitator Superfamily
MC28_2363	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MC28_2368	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_2369	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_2371	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_2375	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MC28_2379	COG0577	efflux transmembrane transporter activity
MC28_2382	COG5002	protein histidine kinase activity
MC28_2382	COG3850	Histidine kinase
MC28_2384	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_2386	COG1619	proteins homologs of microcin C7 resistance protein MccF
MC28_2390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MC28_2400	COG2814	Major facilitator Superfamily
MC28_2405	COG5444	nuclease activity
MC28_2412	COG1876	peptidase activity
MC28_2413	COG2843	Capsule synthesis protein
MC28_2415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_2418	COG0534	Mate efflux family protein
MC28_2423	COG0477	Major facilitator Superfamily
MC28_2426	COG1846	Transcriptional regulator
MC28_2427	COG2814	Major facilitator Superfamily
MC28_2439	COG2031	fatty acid transporter
MC28_2441	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_2452	COG1288	antiporter activity
MC28_2453	COG2356	endonuclease I
MC28_2455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MC28_2456	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MC28_2460	COG1733	regulation of RNA biosynthetic process
MC28_2461	COG0778	Nitroreductase
MC28_2468	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_2475	COG1011	Hydrolase
MC28_2482	COG0346	lactoylglutathione lyase activity
MC28_2483	COG1940	carbohydrate kinase activity
MC28_2484	COG0738	Major facilitator superfamily
MC28_2485	COG0110	maltose O-acetyltransferase activity
MC28_2486	COG0180	Tryptophanyl-tRNA synthetase
MC28_2488	COG0628	permease
MC28_2494	COG0477	Major facilitator Superfamily
MC28_2499	COG1253	flavin adenine dinucleotide binding
MC28_2500	COG0789	Transcriptional regulator
MC28_2506	COG0697	spore germination
MC28_2507	COG1357	PFAM Pentapeptide repeats (8 copies)
MC28_2509	COG2706	6-phosphogluconolactonase activity
MC28_2510	COG1070	Carbohydrate kinase
MC28_2513	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MC28_2514	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MC28_2515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MC28_2517	COG0604	alcohol dehydrogenase
MC28_2518	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MC28_2521	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_2524	COG0840	transmembrane signaling receptor activity
MC28_2526	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_2526	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_2527	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MC28_2528	COG1733	regulation of RNA biosynthetic process
MC28_2531	COG0656	L-ascorbic acid biosynthetic process
MC28_2532	COG2814	Major facilitator Superfamily
MC28_2536	COG1846	Transcriptional regulator
MC28_2537	COG2824	Alkylphosphonate utilization operon protein PhnA
MC28_2538	COG0659	secondary active sulfate transmembrane transporter activity
MC28_2541	COG0814	amino acid
MC28_2542	COG3655	Transcriptional regulator
MC28_2548	COG1393	Belongs to the ArsC family
MC28_2549	COG1733	regulation of RNA biosynthetic process
MC28_2550	COG2188	Transcriptional regulator
MC28_2551	COG0673	inositol 2-dehydrogenase activity
MC28_2552	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MC28_2555	COG1733	regulation of RNA biosynthetic process
MC28_2560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_2565	COG0384	phenazine biosynthesis protein PhzF
MC28_2569	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_2570	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_2571	COG1733	regulation of RNA biosynthetic process
MC28_2574	COG0726	polysaccharide deacetylase
MC28_2576	COG1191	sigma factor activity
MC28_2578	COG1280	lysine exporter protein (LysE YggA)
MC28_2589	COG3757	hydrolase, family 25
MC28_2589	COG3409	Peptidoglycan-binding domain 1 protein
MC28_2596	COG2072	flavoprotein involved in K transport
MC28_2603	COG0604	alcohol dehydrogenase
MC28_2604	COG1113	amino acid transport
MC28_2605	COG0456	acetyltransferase
MC28_2606	COG2814	Major facilitator Superfamily
MC28_2617	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MC28_2618	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MC28_2620	COG1247	-acetyltransferase
MC28_2621	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_2622	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_2623	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_2624	COG3739	integral membrane protein
MC28_2630	COG0583	DNA-binding transcription factor activity
MC28_2634	COG1193	negative regulation of DNA recombination
MC28_2636	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MC28_2637	COG1164	Oligoendopeptidase f
MC28_2642	COG3781	membrane
MC28_2645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_2648	COG0583	DNA-binding transcription factor activity
MC28_2651	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_2654	COG0640	Transcriptional regulator
MC28_2655	COG0604	alcohol dehydrogenase
MC28_2657	COG0457	Tetratricopeptide repeat
MC28_2659	COG2808	Putative FMN-binding domain
MC28_2662	COG0277	FAD linked oxidase domain protein
MC28_2667	COG3300	MHYT domain
MC28_2667	COG5001	Diguanylate cyclase
MC28_2669	COG1876	peptidase activity
MC28_2675	COG2801	Transposase and inactivated derivatives
MC28_2677	COG3852	Histidine kinase
MC28_2679	COG1285	pathogenesis
MC28_2681	COG2514	catechol 2,3-dioxygenase activity
MC28_2682	COG2720	vancomycin resistance protein
MC28_2688	COG1278	Cold shock
MC28_2690	COG0716	FMN binding
MC28_2696	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_2698	COG0165	Argininosuccinate lyase
MC28_2701	COG4145	pantothenate transmembrane transporter activity
MC28_2703	COG1012	belongs to the aldehyde dehydrogenase family
MC28_2704	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_2706	COG1657	PFAM Prenyltransferase squalene oxidase
MC28_2707	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MC28_2708	COG2962	Rard protein
MC28_2712	COG0489	protein tyrosine kinase activity
MC28_2714	COG0314	molybdopterin synthase activity
MC28_2715	COG0303	'Molybdopterin
MC28_2716	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_2717	COG2116	formate transmembrane transporter activity
MC28_2719	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MC28_2720	COG5609	conserved protein (DUF2294)
MC28_2721	COG2427	Protein of unknown function (DUF1641)
MC28_2722	COG3383	formate dehydrogenase (NAD+) activity
MC28_2724	COG0697	spore germination
MC28_2727	COG0531	amino acid
MC28_2734	COG2226	methyltransferase
MC28_2735	COG4166	transmembrane transport
MC28_2736	COG4166	transmembrane transport
MC28_2737	COG4166	transmembrane transport
MC28_2738	COG1301	dicarboxylic acid transport
MC28_2739	COG1316	TRANSCRIPTIONal
MC28_2741	COG1595	DNA-templated transcription, initiation
MC28_2743	COG1131	(ABC) transporter
MC28_2745	COG0673	inositol 2-dehydrogenase activity
MC28_2746	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MC28_2747	COG0187	DNA topoisomerase II activity
MC28_2748	COG1832	CoA-binding protein
MC28_2749	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC28_2750	COG0745	RESPONSE REGULATOR receiver
MC28_2752	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MC28_2752	COG1328	CTP reductase activity
MC28_2754	COG4841	protein insertion into membrane
MC28_2755	COG0824	Thioesterase
MC28_2760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_2762	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MC28_2764	COG0726	polysaccharide deacetylase
MC28_2768	COG2211	Major facilitator Superfamily
MC28_2770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MC28_2773	COG0183	Belongs to the thiolase family
MC28_2774	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_2775	COG1268	BioY protein
MC28_2776	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_2777	COG1396	sequence-specific DNA binding
MC28_2785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_2787	COG5002	protein histidine kinase activity
MC28_2788	COG0400	carboxylic ester hydrolase activity
MC28_2789	COG0346	lactoylglutathione lyase activity
MC28_2790	COG0069	glutamate synthase activity
MC28_2791	COG1902	pentaerythritol trinitrate reductase activity
MC28_2792	COG1329	Transcriptional regulator
MC28_2793	COG0010	Belongs to the arginase family
MC28_2804	COG4846	Membrane protein involved in cytochrome C biogenesis
MC28_2805	COG0785	Cytochrome C biogenesis protein
MC28_2810	COG1131	(ABC) transporter
MC28_2813	COG0583	DNA-binding transcription factor activity
MC28_2815	COG1346	cytolysis
MC28_2818	COG0730	response to heat
MC28_2822	COG3409	Peptidoglycan-binding domain 1 protein
MC28_2822	COG3757	hydrolase, family 25
MC28_2823	COG1132	(ABC) transporter
MC28_2824	COG1132	(ABC) transporter
MC28_2829	COG3639	organic phosphonate transmembrane transporter activity
MC28_2832	COG0737	Belongs to the 5'-nucleotidase family
MC28_2834	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MC28_2838	COG1695	Transcriptional regulator
MC28_2839	COG1132	(ABC) transporter
MC28_2845	COG0367	asparagine synthase
MC28_2846	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MC28_2848	COG1181	Belongs to the D-alanine--D-alanine ligase family
MC28_2849	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MC28_2851	COG3420	alginic acid biosynthetic process
MC28_2851	COG5434	Belongs to the glycosyl hydrolase 28 family
MC28_2856	COG0438	transferase activity, transferring glycosyl groups
MC28_2858	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MC28_2858	COG0463	Glycosyl transferase, family 2
MC28_2859	COG0438	transferase activity, transferring glycosyl groups
MC28_2860	COG0438	transferase activity, transferring glycosyl groups
MC28_2861	COG1086	Polysaccharide biosynthesis protein
MC28_2864	COG0174	glutamine synthetase
MC28_2865	COG0789	Transcriptional regulator
MC28_2866	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MC28_2867	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MC28_2868	COG2860	membrane
MC28_2870	COG0464	growth
MC28_2875	COG2801	Transposase and inactivated derivatives
MC28_2879	COG3584	3D domain protein
MC28_2879	COG1388	LysM domain
MC28_2880	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC28_2880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC28_2880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_2881	COG1105	Belongs to the carbohydrate kinase PfkB family
MC28_2882	COG1349	DNA-binding transcription factor activity
MC28_2883	COG1979	alcohol dehydrogenase
MC28_2884	COG2322	membrane
MC28_2887	COG1113	amino acid transport
MC28_2889	COG1473	amidohydrolase
MC28_2890	COG1408	metallophosphoesterase
MC28_2891	COG2116	formate transmembrane transporter activity
MC28_2894	COG2217	Heavy metal translocating P-type atpase
MC28_2896	COG1937	Protein conserved in bacteria
MC28_2901	COG1120	ATPase activity
MC28_2902	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_2903	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_2904	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_2905	COG0708	Exodeoxyribonuclease III
MC28_2906	COG2169	Transcriptional regulator
MC28_2907	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MC28_2908	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MC28_2910	COG2364	Membrane
MC28_2915	COG3300	MHYT domain
MC28_2915	COG5001	Diguanylate cyclase
MC28_2923	COG1346	cytolysis
MC28_2925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_2926	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_2926	COG0596	Alpha beta hydrolase
MC28_2927	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MC28_2928	COG2188	Transcriptional regulator
MC28_2929	COG2723	6-phospho-beta-galactosidase activity
MC28_2931	COG1404	Belongs to the peptidase S8 family
MC28_2932	COG3773	Cell wall hydrolase
MC28_2934	COG1368	sulfuric ester hydrolase activity
MC28_2940	COG4550	Control of competence regulator ComK, YlbF/YmcA
MC28_2942	COG1013	pyruvate-flavodoxin oxidoreductase activity
MC28_2943	COG0674	pyruvate-flavodoxin oxidoreductase activity
MC28_2943	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MC28_2945	COG2359	stage V sporulation protein S
MC28_2946	COG1692	metallophosphoesterase
MC28_2952	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MC28_2953	COG1426	Protein conserved in bacteria
MC28_2956	COG0300	oxidoreductase activity
MC28_2957	COG0612	Peptidase, M16
MC28_2958	COG0612	Peptidase, M16
MC28_2963	COG2188	Transcriptional regulator
MC28_2964	COG1674	ftsk spoiiie
MC28_2966	COG0740	serine-type endopeptidase activity
MC28_2967	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MC28_2969	COG0527	aspartate kinase activity
MC28_2970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MC28_2971	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MC28_2976	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC28_2982	COG5632	N-Acetylmuramoyl-L-alanine amidase
MC28_2997	COG0740	serine-type endopeptidase activity
MC28_3006	COG1388	LysM domain
MC28_3006	COG3584	3D domain protein
MC28_3008	COG0582	viral genome integration into host DNA
MC28_3015	COG0305	Participates in initiation and elongation during chromosome replication
MC28_3022	COG1396	sequence-specific DNA binding
MC28_3027	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC28_3028	COG1873	PFAM PRC-barrel domain
MC28_3029	COG0612	Peptidase, M16
MC28_3030	COG0726	polysaccharide deacetylase
MC28_3033	COG0196	riboflavin kinase activity
MC28_3037	COG1358	cellular component organization or biogenesis
MC28_3038	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MC28_3039	COG0195	Participates in both transcription termination and antitermination
MC28_3043	COG0750	zinc metalloprotease
MC28_3045	COG4589	Belongs to the CDS family
MC28_3048	COG0528	UMP kinase activity
MC28_3054	COG4974	Belongs to the 'phage' integrase family
MC28_3056	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC28_3057	COG0758	DNA mediated transformation
MC28_3058	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MC28_3066	COG1837	Belongs to the UPF0109 family
MC28_3068	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MC28_3070	COG0552	protein localization to endoplasmic reticulum
MC28_3071	COG1196	nuclear chromosome segregation
MC28_3074	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_3075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MC28_3078	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MC28_3079	COG1461	Dihydroxyacetone kinase
MC28_3080	COG1302	Protein conserved in bacteria
MC28_3082	COG1564	THIamine pyrophosphokinase
MC28_3083	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MC28_3084	COG1162	GTPase activity
MC28_3085	COG0515	serine threonine protein kinase
MC28_3085	COG2815	serine threonine protein kinase
MC28_3086	COG0631	protein serine/threonine phosphatase activity
MC28_3088	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MC28_3088	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MC28_3091	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MC28_3092	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MC28_3094	COG0194	GDP metabolic process
MC28_3096	COG1561	YicC-like family, N-terminal region
MC28_3097	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MC28_3099	COG0006	proline dipeptidase activity
MC28_3103	COG3069	C4-dicarboxylate transmembrane transporter activity
MC28_3115	COG0564	pseudouridine synthase activity
MC28_3119	COG3599	regulation of cell shape
MC28_3120	COG2302	S4 RNA-binding domain
MC28_3122	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MC28_3124	COG1873	PFAM PRC-barrel domain
MC28_3125	COG1191	sigma factor activity
MC28_3126	COG1191	sigma factor activity
MC28_3128	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MC28_3129	COG0849	cell division
MC28_3130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MC28_3133	COG0772	Belongs to the SEDS family
MC28_3137	COG0768	penicillin binding
MC28_3142	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MC28_3146	COG1399	metal-binding, possibly nucleic acid-binding protein
MC28_3154	COG4824	toxin secretion phage lysis holin
MC28_3171	COG0740	serine-type endopeptidase activity
MC28_3173	COG4626	Terminase
MC28_3173	COG1802	Transcriptional regulator
MC28_3179	COG0582	viral genome integration into host DNA
MC28_3197	COG2002	toxin-antitoxin pair type II binding
MC28_3202	COG1396	sequence-specific DNA binding
MC28_3209	COG0582	viral genome integration into host DNA
MC28_3211	COG3480	Lon protease (S16) C-terminal proteolytic domain
MC28_3212	COG1752	Esterase of the alpha-beta hydrolase superfamily
MC28_3213	COG3314	Sporulation integral membrane protein YlbJ
MC28_3215	COG0742	ribosomal rna small subunit methyltransferase
MC28_3218	COG3679	Belongs to the UPF0342 family
MC28_3219	COG0406	alpha-ribazole phosphatase activity
MC28_3222	COG2340	Cysteine-rich secretory protein family
MC28_3225	COG3336	cytochrome c oxidase
MC28_3232	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MC28_3234	COG0772	Belongs to the SEDS family
MC28_3236	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MC28_3237	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MC28_3239	COG4896	Protein conserved in bacteria
MC28_3244	COG0483	inositol monophosphate 1-phosphatase activity
MC28_3248	COG1982	Orn Lys Arg decarboxylase major
MC28_3260	COG0022	dehydrogenase e1 component
MC28_3261	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MC28_3263	COG0242	peptide deformylase activity
MC28_3264	COG0561	phosphatase activity
MC28_3266	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MC28_3267	COG0569	domain protein
MC28_3271	COG0583	DNA-binding transcription factor activity
MC28_3272	COG0517	IMP dehydrogenase activity
MC28_3274	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MC28_3275	COG4703	Protein of unknown function (DUF1797)
MC28_3279	COG2200	EAL domain
MC28_3280	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_3281	COG1408	metallophosphoesterase
MC28_3283	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MC28_3291	COG2814	Major facilitator Superfamily
MC28_3295	COG3209	COG3209 Rhs family protein
MC28_3297	COG2205	protein histidine kinase activity
MC28_3299	COG0436	Aminotransferase
MC28_3300	COG1609	Transcriptional regulator
MC28_3301	COG3833	ABC-type maltose transport systems, permease component
MC28_3302	COG1175	transmembrane transport
MC28_3303	COG2182	Extracellular solute-binding protein
MC28_3305	COG0366	Alpha amylase catalytic
MC28_3306	COG3842	ATPase activity
MC28_3314	COG0183	Belongs to the thiolase family
MC28_3321	COG1695	Transcriptional regulator
MC28_3322	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_3326	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MC28_3327	COG0436	Aminotransferase
MC28_3334	COG2084	Dehydrogenase
MC28_3336	COG2203	Gaf domain
MC28_3336	COG2199	diguanylate cyclase activity
MC28_3337	COG0778	Nitroreductase
MC28_3342	COG1263	PTS System
MC28_3342	COG2190	(PTS) system
MC28_3342	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_3343	COG3711	transcriptional antiterminator
MC28_3347	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MC28_3351	COG1547	Domain of unknown function (DUF309)
MC28_3352	COG0456	acetyltransferase
MC28_3353	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MC28_3354	COG4086	secreted protein
MC28_3355	COG0561	phosphatase activity
MC28_3356	COG0697	spore germination
MC28_3359	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_3364	COG0733	neurotransmitter:sodium symporter activity
MC28_3368	COG1686	Belongs to the peptidase S11 family
MC28_3369	COG1725	Transcriptional regulator
MC28_3370	COG1131	(ABC) transporter
MC28_3374	COG1846	Transcriptional regulator
MC28_3377	COG0598	Magnesium transport protein CorA
MC28_3382	COG4974	Belongs to the 'phage' integrase family
MC28_3384	COG0735	belongs to the Fur family
MC28_3385	COG1300	Membrane
MC28_3389	COG0667	Aldo Keto reductase
MC28_3390	COG0656	L-ascorbic acid biosynthetic process
MC28_3391	COG0456	acetyltransferase
MC28_3391	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MC28_3393	COG0737	Belongs to the 5'-nucleotidase family
MC28_3393	COG1525	nuclease
MC28_3393	COG4085	toxin activity
MC28_3395	COG0596	Alpha beta hydrolase
MC28_3396	COG2056	Na+-H+ antiporter family
MC28_3397	COG1609	Transcriptional regulator
MC28_3398	COG0456	acetyltransferase
MC28_3399	COG1073	alpha beta
MC28_3402	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_3402	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MC28_3403	COG0307	riboflavin synthase, alpha
MC28_3408	COG4106	trans-aconitate 2-methyltransferase activity
MC28_3409	COG2226	methyltransferase
MC28_3409	COG1073	alpha beta
MC28_3412	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MC28_3415	COG0737	Belongs to the 5'-nucleotidase family
MC28_3417	COG1522	sequence-specific DNA binding
MC28_3426	COG0300	oxidoreductase activity
MC28_3427	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_3428	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC28_3430	COG1760	l-serine dehydratase
MC28_3436	COG1285	pathogenesis
MC28_3438	COG2195	Cleaves the N-terminal amino acid of tripeptides
MC28_3439	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_3441	COG1376	ErfK ybiS ycfS ynhG family protein
MC28_3442	COG4129	membrane
MC28_3443	COG1126	abc transporter atp-binding protein
MC28_3444	COG0765	amino acid transport
MC28_3445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_3449	COG2323	membrane
MC28_3450	COG0772	Belongs to the SEDS family
MC28_3451	COG0508	dehydrogenase complex catalyzes the overall conversion of
MC28_3452	COG0022	dehydrogenase e1 component
MC28_3453	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MC28_3454	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MC28_3456	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MC28_3457	COG0280	phosphate acetyltransferase
MC28_3458	COG3829	transcription factor binding
MC28_3458	COG3290	protein histidine kinase activity
MC28_3460	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_3461	COG3093	addiction module antidote protein HigA
MC28_3462	COG1215	transferase activity, transferring glycosyl groups
MC28_3464	COG0745	RESPONSE REGULATOR receiver
MC28_3465	COG0750	zinc metalloprotease
MC28_3466	COG0497	DNA recombination
MC28_3468	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MC28_3470	COG0142	geranyltranstransferase activity
MC28_3475	COG1302	Protein conserved in bacteria
MC28_3476	COG0439	Biotin carboxylase
MC28_3486	COG3854	ATPases associated with a variety of cellular activities
MC28_3491	COG0006	proline dipeptidase activity
MC28_3494	COG3872	metal-dependent enzyme
MC28_3496	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MC28_3502	COG0095	Lipoate-protein ligase
MC28_3503	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_3505	COG1609	Transcriptional regulator
MC28_3507	COG2076	Multidrug Resistance protein
MC28_3508	COG2076	Multidrug Resistance protein
MC28_3513	COG1131	(ABC) transporter
MC28_3514	COG1725	Transcriptional regulator
MC28_3520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC28_3532	COG4970	Tfp pilus assembly protein FimT
MC28_3533	COG4537	Required for transformation and DNA binding
MC28_3534	COG1459	type II secretion system
MC28_3535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MC28_3546	COG0646	methionine synthase
MC28_3546	COG1410	methionine synthase
MC28_3547	COG0646	methionine synthase
MC28_3547	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MC28_3548	COG0626	cystathionine gamma-synthase activity
MC28_3549	COG0626	cystathionine gamma-synthase activity
MC28_3554	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_3556	COG1940	carbohydrate kinase activity
MC28_3557	COG4483	Protein conserved in bacteria
MC28_3558	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MC28_3559	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MC28_3560	COG0704	Plays a role in the regulation of phosphate uptake
MC28_3562	COG0581	inorganic phosphate transmembrane transporter activity
MC28_3563	COG0573	inorganic phosphate transmembrane transporter activity
MC28_3564	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MC28_3566	COG0477	Major facilitator Superfamily
MC28_3567	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC28_3571	COG0735	belongs to the Fur family
MC28_3572	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MC28_3573	COG1121	(ABC) transporter
MC28_3574	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_3581	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MC28_3582	COG2384	SAM-dependent methyltransferase
MC28_3583	COG2010	Cytochrome c
MC28_3584	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MC28_3585	COG0358	DNA primase activity
MC28_3586	COG1671	Belongs to the UPF0178 family
MC28_3588	COG0517	IMP dehydrogenase activity
MC28_3591	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MC28_3592	COG0295	cytidine deaminase activity
MC28_3593	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MC28_3595	COG1480	7TM receptor with intracellular HD hydrolase
MC28_3596	COG1702	phosphate starvation-inducible protein PhoH
MC28_3599	COG1610	YqeY-like protein
MC28_3601	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MC28_3602	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MC28_3608	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MC28_3609	COG1733	regulation of RNA biosynthetic process
MC28_3614	COG1466	dna polymerase III delta subunit
MC28_3617	COG0658	competence protein
MC28_3617	COG2333	competence protein COMEC
MC28_3618	COG2131	deaminase
MC28_3619	COG1555	photosystem II stabilization
MC28_3619	COG1596	polysaccharide export
MC28_3620	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MC28_3621	COG2226	methyltransferase
MC28_3622	COG0799	negative regulation of ribosome biogenesis
MC28_3623	COG1713	HD superfamily hydrolase involved in NAD metabolism
MC28_3625	COG1534	Rna-binding protein
MC28_3627	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MC28_3628	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MC28_3631	COG1191	sigma factor activity
MC28_3635	COG0778	Nitroreductase
MC28_3636	COG2357	RelA SpoT domain protein
MC28_3638	COG1785	Belongs to the alkaline phosphatase family
MC28_3640	COG2267	carboxylic ester hydrolase activity
MC28_3647	COG1404	Belongs to the peptidase S8 family
MC28_3648	COG3186	Phenylalanine-4-hydroxylase
MC28_3650	COG2514	catechol 2,3-dioxygenase activity
MC28_3651	COG2259	Doxx family
MC28_3659	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_3662	COG1012	belongs to the aldehyde dehydrogenase family
MC28_3662	COG1454	alcohol dehydrogenase
MC28_3663	COG0626	cystathionine gamma-synthase activity
MC28_3664	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC28_3669	COG0768	penicillin binding
MC28_3675	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MC28_3681	COG0628	permease
MC28_3685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MC28_3688	COG1104	cysteine desulfurase activity
MC28_3689	COG1959	2 iron, 2 sulfur cluster binding
MC28_3690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MC28_3692	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MC28_3699	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MC28_3701	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MC28_3701	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MC28_3702	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MC28_3703	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC28_3703	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MC28_3705	COG2244	polysaccharide biosynthetic process
MC28_3706	COG2323	membrane
MC28_3708	COG1862	Preprotein translocase
MC28_3714	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MC28_3720	COG0157	Belongs to the NadC ModD family
MC28_3721	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MC28_3722	COG1104	cysteine desulfurase activity
MC28_3723	COG1827	regulation of RNA biosynthetic process
MC28_3724	COG2258	MOSC domain
MC28_3725	COG0077	Prephenate dehydratase
MC28_3727	COG0577	efflux transmembrane transporter activity
MC28_3728	COG0577	efflux transmembrane transporter activity
MC28_3729	COG1136	(ABC) transporter
MC28_3730	COG5002	protein histidine kinase activity
MC28_3731	COG0745	RESPONSE REGULATOR receiver
MC28_3733	COG3290	protein histidine kinase activity
MC28_3735	COG2868	ribosomal protein
MC28_3737	COG1530	ribonuclease E activity
MC28_3738	COG1994	Peptidase M50
MC28_3739	COG0739	heme binding
MC28_3740	COG2894	cell division
MC28_3743	COG1792	Involved in formation and maintenance of cell shape
MC28_3744	COG1077	Cell shape determining protein MreB Mrl
MC28_3749	COG0285	dihydrofolate synthase activity
MC28_3752	COG1388	LysM domain
MC28_3754	COG0113	porphobilinogen synthase activity
MC28_3755	COG1587	Uroporphyrinogen-III synthase
MC28_3757	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MC28_3759	COG1846	Transcriptional regulator
MC28_3760	COG1764	response to oxidative stress
MC28_3763	COG1067	ATP-dependent peptidase activity
MC28_3763	COG0470	DNA polymerase III
MC28_3770	COG0622	Phosphoesterase
MC28_3773	COG5401	PFAM Sporulation and spore germination
MC28_3777	COG1309	transcriptional regulator
MC28_3779	COG2197	response regulator
MC28_3780	COG2233	PERMEase
MC28_3781	COG0402	S-adenosylhomocysteine deaminase activity
MC28_3783	COG1396	sequence-specific DNA binding
MC28_3784	COG0697	spore germination
MC28_3786	COG1959	2 iron, 2 sulfur cluster binding
MC28_3787	COG1668	transmembrane transport
MC28_3788	COG4152	abc transporter atp-binding protein
MC28_3789	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
MC28_3790	COG1360	Flagellar Motor Protein
MC28_3791	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MC28_3792	COG1876	peptidase activity
MC28_3793	COG0824	Thioesterase
MC28_3794	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MC28_3795	COG1053	succinate dehydrogenase
MC28_3796	COG2009	succinate dehydrogenase
MC28_3797	COG1719	4-vinyl reductase, 4VR
MC28_3800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MC28_3801	COG2086	electron transfer activity
MC28_3802	COG1024	Enoyl-CoA hydratase
MC28_3803	COG1309	transcriptional regulator
MC28_3804	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_3810	COG2318	DinB family
MC28_3816	COG1131	(ABC) transporter
MC28_3817	COG2205	protein histidine kinase activity
MC28_3818	COG0745	RESPONSE REGULATOR receiver
MC28_3820	COG4895	conserved protein (DUF2196)
MC28_3821	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MC28_3823	COG4509	Sortase family
MC28_3824	COG1120	ATPase activity
MC28_3827	COG5386	Cell surface protein
MC28_3829	COG5386	Cell surface protein
MC28_3830	COG1114	Component of the transport system for branched-chain amino acids
MC28_3831	COG1187	pseudouridine synthase activity
MC28_3833	COG1796	DNA polymerase
MC28_3833	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MC28_3834	COG1286	toxin biosynthetic process
MC28_3842	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC28_3844	COG1418	mRNA catabolic process
MC28_3847	COG2814	Major facilitator Superfamily
MC28_3848	COG1566	PFAM secretion protein HlyD family protein
MC28_3849	COG1309	transcriptional regulator
MC28_3850	COG1363	Peptidase, m42
MC28_3854	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MC28_3855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MC28_3857	COG1484	DNA-dependent DNA replication
MC28_3858	COG3611	Membrane attachment protein
MC28_3861	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC28_3862	COG0237	dephospho-CoA kinase activity
MC28_3865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC28_3865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MC28_3866	COG5002	protein histidine kinase activity
MC28_3867	COG0745	RESPONSE REGULATOR receiver
MC28_3871	COG0538	isocitrate dehydrogenase activity
MC28_3872	COG0372	Belongs to the citrate synthase family
MC28_3874	COG0628	permease
MC28_3880	COG1725	Transcriptional regulator
MC28_3881	COG0281	malic enzyme
MC28_3882	COG0587	DNA-directed DNA polymerase activity
MC28_3885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MC28_3888	COG4109	DRTGG domain
MC28_3891	COG0006	proline dipeptidase activity
MC28_3898	COG0662	Cupin 2, conserved barrel domain protein
MC28_3901	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_3902	COG0589	response to stress
MC28_3903	COG0346	lactoylglutathione lyase activity
MC28_3911	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_3916	COG0827	DNA restriction-modification system
MC28_3917	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MC28_3918	COG3874	Sporulation protein YtfJ
MC28_3921	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MC28_3923	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC28_3926	COG1104	cysteine desulfurase activity
MC28_3928	COG0583	DNA-binding transcription factor activity
MC28_3929	COG0697	spore germination
MC28_3930	COG1309	transcriptional regulator
MC28_3931	COG1956	GAF domain-containing protein
MC28_3932	COG0626	cystathionine gamma-synthase activity
MC28_3939	COG1595	DNA-templated transcription, initiation
MC28_3941	COG0110	maltose O-acetyltransferase activity
MC28_3942	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MC28_3943	COG0454	-acetyltransferase
MC28_3944	COG0517	IMP dehydrogenase activity
MC28_3945	COG0123	including yeast histone deacetylase and acetoin utilization protein
MC28_3948	COG0745	RESPONSE REGULATOR receiver
MC28_3949	COG5002	protein histidine kinase activity
MC28_3950	COG0666	response to abiotic stimulus
MC28_3956	COG1609	Transcriptional regulator
MC28_3958	COG4851	CamS sex pheromone cAM373 precursor
MC28_3959	COG3118	belongs to the thioredoxin family
MC28_3961	COG2309	aminopeptidase activity
MC28_3965	COG0697	spore germination
MC28_3966	COG0789	Transcriptional regulator
MC28_3969	COG1674	ftsk spoiiie
MC28_3970	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_3970	COG1388	LysM domain
MC28_3972	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC28_3974	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_3975	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
MC28_3976	COG1363	Peptidase, m42
MC28_3978	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_3981	COG0510	thiamine kinase activity
MC28_3982	COG1523	belongs to the glycosyl hydrolase 13 family
MC28_3984	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC28_3985	COG1349	DNA-binding transcription factor activity
MC28_3986	COG1187	pseudouridine synthase activity
MC28_3987	COG2244	polysaccharide biosynthetic process
MC28_3988	COG2081	HI0933 family
MC28_3989	COG2814	Major facilitator Superfamily
MC28_3991	COG3832	glyoxalase III activity
MC28_3994	COG1329	Transcriptional regulator
MC28_3999	COG0314	molybdopterin synthase activity
MC28_4000	COG1763	Mo-molybdopterin cofactor biosynthetic process
MC28_4001	COG0303	'Molybdopterin
MC28_4003	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MC28_4004	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MC28_4008	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_4010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MC28_4020	COG2814	Major facilitator Superfamily
MC28_4021	COG0475	glutathione-regulated potassium exporter activity
MC28_4022	COG0490	domain, Protein
MC28_4023	COG0582	viral genome integration into host DNA
MC28_4030	COG1242	4 iron, 4 sulfur cluster binding
MC28_4031	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MC28_4034	COG1794	racemase activity, acting on amino acids and derivatives
MC28_4035	COG1253	flavin adenine dinucleotide binding
MC28_4040	COG0656	L-ascorbic acid biosynthetic process
MC28_4045	COG2267	carboxylic ester hydrolase activity
MC28_4047	COG0671	phosphoesterase, PA-phosphatase related
MC28_4048	COG0438	transferase activity, transferring glycosyl groups
MC28_4061	COG3852	Histidine kinase
MC28_4062	COG3852	Histidine kinase
MC28_4065	COG1368	sulfuric ester hydrolase activity
MC28_4068	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MC28_4069	COG1116	anion transmembrane transporter activity
MC28_4070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_4075	COG0494	nUDIX hydrolase
MC28_4081	COG0288	reversible hydration of carbon dioxide
MC28_4082	COG1271	oxidase subunit
MC28_4083	COG1294	oxidase, subunit
MC28_4086	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_4091	COG1842	Phage shock protein A
MC28_4097	COG5002	protein histidine kinase activity
MC28_4098	COG0745	RESPONSE REGULATOR receiver
MC28_4104	COG1597	lipid kinase activity
MC28_4108	COG0577	efflux transmembrane transporter activity
MC28_4109	COG1136	(ABC) transporter
MC28_4113	COG0586	Pfam SNARE associated Golgi protein
MC28_4114	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MC28_4115	COG0577	efflux transmembrane transporter activity
MC28_4116	COG1136	(ABC) transporter
MC28_4117	COG2207	Transcriptional regulator
MC28_4117	COG3708	Transcriptional regulator
MC28_4120	COG5658	integral membrane protein
MC28_4121	COG0640	Transcriptional regulator
MC28_4124	COG1595	DNA-templated transcription, initiation
MC28_4125	COG0745	RESPONSE REGULATOR receiver
MC28_4126	COG2205	protein histidine kinase activity
MC28_4127	COG0577	efflux transmembrane transporter activity
MC28_4128	COG0577	efflux transmembrane transporter activity
MC28_4129	COG1136	(ABC) transporter
MC28_4130	COG0577	efflux transmembrane transporter activity
MC28_4137	COG3964	amidohydrolase
MC28_4140	COG0745	RESPONSE REGULATOR receiver
MC28_4141	COG4948	Mandelate Racemase Muconate Lactonizing
MC28_4143	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MC28_4146	COG1169	isochorismate synthase
MC28_4147	COG1575	Belongs to the MenA family. Type 1 subfamily
MC28_4148	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MC28_4149	COG1278	Cold shock
MC28_4153	COG0058	SHG alpha-glucan phosphorylase activity
MC28_4155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MC28_4159	COG1404	Belongs to the peptidase S8 family
MC28_4160	COG0039	L-malate dehydrogenase activity
MC28_4163	COG1285	pathogenesis
MC28_4164	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MC28_4167	COG2155	Conserved Protein
MC28_4168	COG1098	S1 RNA binding domain
MC28_4169	COG0436	Aminotransferase
MC28_4170	COG1522	sequence-specific DNA binding
MC28_4171	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MC28_4172	COG2267	carboxylic ester hydrolase activity
MC28_4174	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MC28_4180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MC28_4183	COG0423	glycine-tRNA ligase activity
MC28_4184	COG2050	protein possibly involved in aromatic compounds catabolism
MC28_4186	COG1268	BioY protein
MC28_4187	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MC28_4188	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MC28_4191	COG3584	3D domain protein
MC28_4194	COG1252	NADH dehydrogenase
MC28_4196	COG3708	Transcriptional regulator
MC28_4199	COG1683	Conserved Protein
MC28_4203	COG0316	Belongs to the HesB IscA family
MC28_4206	COG1252	NADH dehydrogenase
MC28_4208	COG0390	transport system, permease component
MC28_4209	COG2824	Alkylphosphonate utilization operon protein PhnA
MC28_4214	COG4837	Protein of unknown function (DUF1462)
MC28_4217	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MC28_4218	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MC28_4222	COG2249	NAD(P)H dehydrogenase (quinone) activity
MC28_4224	COG0647	UMP catabolic process
MC28_4226	COG2445	Protein of unknown function DUF86
MC28_4227	COG1494	fructose-1,6-bisphosphatase
MC28_4233	COG0789	Transcriptional regulator
MC28_4234	COG4377	Putative membrane peptidase family (DUF2324)
MC28_4239	COG0739	heme binding
MC28_4241	COG3377	Domain of unknown function (DUF1805)
MC28_4242	COG0737	Belongs to the 5'-nucleotidase family
MC28_4243	COG0719	Fe-S assembly protein
MC28_4244	COG0822	iron-sulfur transferase activity
MC28_4245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MC28_4246	COG0719	Fe-S assembly protein
MC28_4247	COG0396	ATPase activity
MC28_4248	COG1464	Belongs to the NlpA lipoprotein family
MC28_4249	COG1464	Belongs to the NlpA lipoprotein family
MC28_4254	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MC28_4255	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MC28_4257	COG1393	Belongs to the ArsC family
MC28_4265	COG0039	L-malate dehydrogenase activity
MC28_4270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_4271	COG1960	acyl-CoA dehydrogenase activity
MC28_4273	COG0183	Belongs to the thiolase family
MC28_4274	COG1250	3-hydroxyacyl-CoA dehydrogenase
MC28_4274	COG1024	Enoyl-CoA hydratase
MC28_4276	COG1686	Belongs to the peptidase S11 family
MC28_4279	COG0011	TIGRFAM Protein of
MC28_4280	COG0840	transmembrane signaling receptor activity
MC28_4283	COG2814	Major facilitator Superfamily
MC28_4284	COG0531	amino acid
MC28_4288	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_4294	COG0586	Pfam SNARE associated Golgi protein
MC28_4296	COG1376	ErfK ybiS ycfS ynhG family protein
MC28_4297	COG0745	RESPONSE REGULATOR receiver
MC28_4298	COG5002	protein histidine kinase activity
MC28_4302	COG0840	transmembrane signaling receptor activity
MC28_4303	COG0840	transmembrane signaling receptor activity
MC28_4304	COG2151	metal-sulfur cluster biosynthetic enzyme
MC28_4305	COG3227	Zinc metalloprotease (Elastase)
MC28_4309	COG0586	Pfam SNARE associated Golgi protein
MC28_4310	COG0475	glutathione-regulated potassium exporter activity
MC28_4311	COG0490	domain, Protein
MC28_4312	COG1115	amino acid carrier protein
MC28_4313	COG0783	Belongs to the Dps family
MC28_4316	COG1611	Belongs to the LOG family
MC28_4318	COG1528	Iron-storage protein
MC28_4319	COG2311	Membrane
MC28_4320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_4321	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_4322	COG1115	amino acid carrier protein
MC28_4323	COG1115	amino acid carrier protein
MC28_4327	COG0656	L-ascorbic acid biosynthetic process
MC28_4328	COG2814	Major facilitator Superfamily
MC28_4329	COG1733	regulation of RNA biosynthetic process
MC28_4331	COG1252	NADH dehydrogenase
MC28_4335	COG0840	transmembrane signaling receptor activity
MC28_4335	COG3290	protein histidine kinase activity
MC28_4337	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MC28_4338	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MC28_4342	COG0488	(ABC) transporter
MC28_4343	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MC28_4344	COG3223	Belongs to the PsiE family
MC28_4347	COG1335	isochorismatase
MC28_4348	COG1522	sequence-specific DNA binding
MC28_4350	COG1522	sequence-specific DNA binding
MC28_4351	COG0288	reversible hydration of carbon dioxide
MC28_4352	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
MC28_4353	COG2233	PERMEase
MC28_4361	COG0557	exoribonuclease II activity
MC28_4363	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MC28_4364	COG1346	cytolysis
MC28_4371	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MC28_4374	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MC28_4380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MC28_4383	COG2323	membrane
MC28_4386	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_4388	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MC28_4390	COG1051	belongs to the nudix hydrolase family
MC28_4393	COG0457	Tetratricopeptide repeat
MC28_4394	COG0110	maltose O-acetyltransferase activity
MC28_4399	COG1950	PFAM Membrane protein of
MC28_4401	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MC28_4402	COG0556	nucleotide-excision repair
MC28_4404	COG0789	Transcriptional regulator
MC28_4408	COG0583	DNA-binding transcription factor activity
MC28_4414	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC28_4415	COG0793	Belongs to the peptidase S41A family
MC28_4415	COG3409	Peptidoglycan-binding domain 1 protein
MC28_4416	COG2177	Part of the ABC transporter FtsEX involved in
MC28_4417	COG2884	Cell division ATP-binding protein ftsE
MC28_4423	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MC28_4425	COG1278	Cold shock
MC28_4427	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MC28_4428	COG0791	NLP P60 protein
MC28_4428	COG1388	LysM domain
MC28_4430	COG1307	EDD domain protein, DegV family
MC28_4431	COG1739	Uncharacterized protein family UPF0029
MC28_4432	COG1316	TRANSCRIPTIONal
MC28_4433	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MC28_4434	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MC28_4435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MC28_4437	COG3933	PFAM sigma-54 factor interaction domain-containing protein
MC28_4437	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MC28_4441	COG1486	melibiose metabolic process
MC28_4442	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC28_4443	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC28_4446	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MC28_4448	COG1447	Phosphotransferase system cellobiose-specific component IIA
MC28_4450	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MC28_4451	COG1301	dicarboxylic acid transport
MC28_4454	COG1511	domain protein
MC28_4455	COG0583	DNA-binding transcription factor activity
MC28_4456	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MC28_4458	COG1271	oxidase subunit
MC28_4459	COG1294	oxidase, subunit
MC28_4460	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MC28_4462	COG1620	l-lactate permease
MC28_4464	COG2389	metal-binding protein
MC28_4466	COG1368	sulfuric ester hydrolase activity
MC28_4469	COG1388	LysM domain
MC28_4469	COG0791	NLP P60 protein
MC28_4470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_4472	COG1215	transferase activity, transferring glycosyl groups
MC28_4473	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MC28_4475	COG1388	LysM domain
MC28_4475	COG3584	3D domain protein
MC28_4477	COG4715	Zinc finger, swim domain protein
MC28_4478	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MC28_4486	COG0577	efflux transmembrane transporter activity
MC28_4487	COG1136	(ABC) transporter
MC28_4492	COG2205	protein histidine kinase activity
MC28_4493	COG0745	RESPONSE REGULATOR receiver
MC28_4494	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC28_4495	COG4750	Nucleotidyl transferase
MC28_4496	COG0697	spore germination
MC28_4498	COG3475	LICD family
MC28_4502	COG0438	transferase activity, transferring glycosyl groups
MC28_4503	COG0463	Glycosyl transferase, family 2
MC28_4503	COG1216	Glycosyl transferase, family 2
MC28_4510	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MC28_4511	COG4464	protein tyrosine phosphatase activity
MC28_4512	COG0489	protein tyrosine kinase activity
MC28_4513	COG3944	biosynthesis protein
MC28_4514	COG0489	protein tyrosine kinase activity
MC28_4517	COG1609	Transcriptional regulator
MC28_4519	COG0739	heme binding
MC28_4522	COG3279	Response regulator of the LytR AlgR family
MC28_4523	COG2385	sporulation resulting in formation of a cellular spore
MC28_4524	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MC28_4526	COG4836	Membrane
MC28_4527	COG1007	ATP synthesis coupled electron transport
MC28_4528	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC28_4529	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MC28_4531	COG0839	Belongs to the complex I subunit 6 family
MC28_4535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MC28_4548	COG0356	it plays a direct role in the translocation of protons across the membrane
MC28_4555	COG0698	ribose 5-phosphate isomerase
MC28_4557	COG2190	(PTS) system
MC28_4558	COG2259	Doxx family
MC28_4559	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MC28_4562	COG0009	L-threonylcarbamoyladenylate synthase
MC28_4568	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MC28_4569	COG1494	fructose-1,6-bisphosphatase
MC28_4573	COG4821	SIS domain
MC28_4577	COG1960	acyl-CoA dehydrogenase activity
MC28_4578	COG1960	acyl-CoA dehydrogenase activity
MC28_4579	COG1250	3-hydroxyacyl-CoA dehydrogenase
MC28_4580	COG0183	Belongs to the thiolase family
MC28_4581	COG2181	nitrate reductase activity
MC28_4581	COG0247	lactate metabolic process
MC28_4582	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MC28_4584	COG3300	MHYT domain
MC28_4584	COG5001	Diguanylate cyclase
MC28_4587	COG3227	Zinc metalloprotease (Elastase)
MC28_4588	COG2197	response regulator
MC28_4589	COG4585	Histidine kinase
MC28_4590	COG0842	Transport permease protein
MC28_4591	COG1131	(ABC) transporter
MC28_4592	COG0024	Methionine aminopeptidase
MC28_4594	COG2234	aminopeptidase activity
MC28_4599	COG4506	Protein conserved in bacteria
MC28_4600	COG1619	proteins homologs of microcin C7 resistance protein MccF
MC28_4605	COG2814	Major facilitator Superfamily
MC28_4606	COG0789	Transcriptional regulator
MC28_4607	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_4608	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_4610	COG1994	Peptidase M50
MC28_4612	COG1078	dGTPase activity
MC28_4613	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_4614	COG1120	ATPase activity
MC28_4615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_4616	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_4620	COG0280	phosphate acetyltransferase
MC28_4623	COG3773	Cell wall hydrolase
MC28_4625	COG2363	Small membrane protein
MC28_4627	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MC28_4628	COG2233	PERMEase
MC28_4629	COG0561	phosphatase activity
MC28_4630	COG2814	Major facilitator Superfamily
MC28_4632	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MC28_4633	COG1131	(ABC) transporter
MC28_4634	COG2755	lipolytic protein G-D-S-L family
MC28_4635	COG1609	Transcriptional regulator
MC28_4637	COG0460	homoserine dehydrogenase
MC28_4641	COG1011	Hydrolase
MC28_4642	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC28_4644	COG2197	response regulator
MC28_4645	COG4585	Histidine kinase
MC28_4645	COG2203	Gaf domain
MC28_4646	COG0351	phosphomethylpyrimidine kinase
MC28_4647	COG3706	GGDEF domain
MC28_4648	COG2879	small protein
MC28_4649	COG1966	Carbon starvation protein
MC28_4650	COG3279	Response regulator of the LytR AlgR family
MC28_4651	COG0477	Major facilitator Superfamily
MC28_4654	COG0438	transferase activity, transferring glycosyl groups
MC28_4657	COG0840	transmembrane signaling receptor activity
MC28_4659	COG1607	acyl-coa hydrolase
MC28_4661	COG1215	transferase activity, transferring glycosyl groups
MC28_4663	COG1309	transcriptional regulator
MC28_4664	COG0488	(ABC) transporter
MC28_4667	COG0463	Glycosyl transferase, family 2
MC28_4668	COG1309	transcriptional regulator
MC28_4669	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC28_4670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC28_4670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MC28_4671	COG0628	permease
MC28_4675	COG3275	phosphorelay sensor kinase activity
MC28_4676	COG2814	Major facilitator Superfamily
MC28_4677	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MC28_4678	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MC28_4679	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MC28_4683	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MC28_4684	COG1272	protein, Hemolysin III
MC28_4689	COG1164	Oligoendopeptidase f
MC28_4693	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC28_4694	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MC28_4695	COG4853	Protein conserved in bacteria
MC28_4697	COG5002	protein histidine kinase activity
MC28_4698	COG0745	RESPONSE REGULATOR receiver
MC28_4700	COG0305	Participates in initiation and elongation during chromosome replication
MC28_4702	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MC28_4703	COG4241	membrane
MC28_4705	COG0629	single-stranded DNA binding
MC28_4707	COG0012	GTP binding
MC28_4708	COG4481	Protein conserved in bacteria
MC28_4709	COG0668	transmembrane transport
MC28_4711	COG1475	DNA binding
MC28_4712	COG1192	Involved in chromosome partitioning
MC28_4717	COG1847	R3H domain protein
MC28_4718	COG0706	membrane insertase activity
MC28_4722	COG0592	DNA-directed DNA polymerase activity
MC28_4723	COG2501	S4 domain
MC28_4725	COG0187	DNA topoisomerase II activity
MC28_4726	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MC28_4728	COG0516	GMP reductase activity
MC28_4728	COG0517	IMP dehydrogenase activity
MC28_4729	COG1686	Belongs to the peptidase S11 family
MC28_4734	COG1428	Deoxynucleoside kinase
MC28_4735	COG1428	Deoxynucleoside kinase
MC28_4736	COG1335	isochorismatase
MC28_4737	COG0590	tRNA wobble adenosine to inosine editing
MC28_4738	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MC28_4744	COG1982	Orn Lys Arg decarboxylase major
MC28_4746	COG0470	DNA polymerase III
MC28_4747	COG1774	PSP1 C-terminal conserved region
MC28_4749	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MC28_4751	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MC28_4752	COG2002	toxin-antitoxin pair type II binding
MC28_4754	COG0084	hydrolase, TatD family'
MC28_4758	COG4466	Protein conserved in bacteria
MC28_4761	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MC28_4762	COG0251	oxidation-reduction process
MC28_4763	COG2088	sporulation resulting in formation of a cellular spore
MC28_4765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MC28_4768	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MC28_4769	COG2002	toxin-antitoxin pair type II binding
MC28_4770	COG3956	TIGRFAM MazG family protein
MC28_4771	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MC28_4775	COG1098	S1 RNA binding domain
MC28_4776	COG2208	phosphoserine phosphatase activity
MC28_4779	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MC28_4782	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC28_4783	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MC28_4784	COG0512	Glutamine amidotransferase of anthranilate synthase
MC28_4785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MC28_4786	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MC28_4787	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MC28_4788	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MC28_4789	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC28_4792	COG3880	PFAM UvrB UvrC protein
MC28_4794	COG0542	response to heat
MC28_4795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MC28_4797	COG4956	integral membrane protein (PIN domain superfamily)
MC28_4801	COG1045	serine acetyltransferase
MC28_4804	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MC28_4805	COG3688	RNA-binding protein containing a PIN domain
MC28_4808	COG0250	Participates in transcription elongation, termination and antitermination
MC28_4813	COG2813	Specifically methylates the guanine in position
MC28_4816	COG1358	cellular component organization or biogenesis
MC28_4837	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MC28_4842	COG0201	protein transport
MC28_4844	COG0024	Methionine aminopeptidase
MC28_4846	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MC28_4852	COG1122	ATPase activity
MC28_4853	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MC28_4854	COG0101	tRNA pseudouridine synthase activity
MC28_4858	COG0860	N-Acetylmuramoyl-L-alanine amidase
MC28_4859	COG0489	protein tyrosine kinase activity
MC28_4861	COG2194	sulfuric ester hydrolase activity
MC28_4862	COG0726	polysaccharide deacetylase
MC28_4866	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MC28_4867	COG4856	YbbR-like protein
MC28_4868	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MC28_4875	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_4877	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MC28_4878	COG1464	Belongs to the NlpA lipoprotein family
MC28_4881	COG0277	FAD linked oxidase domain protein
MC28_4884	COG2814	Major facilitator Superfamily
MC28_4887	COG0601	transmembrane transport
MC28_4888	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MC28_4889	COG0444	Belongs to the ABC transporter superfamily
MC28_4891	COG4166	transmembrane transport
MC28_4893	COG2207	Transcriptional regulator
MC28_4894	COG4166	transmembrane transport
MC28_4895	COG4166	transmembrane transport
MC28_4896	COG0656	L-ascorbic acid biosynthetic process
MC28_4901	COG0725	ABC transporter, periplasmic molybdate-binding protein
MC28_4902	COG1910	domain protein
MC28_4904	COG0697	spore germination
MC28_4906	COG1609	Transcriptional regulator
MC28_4908	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MC28_4912	COG5298	Protein conserved in bacteria
MC28_4916	COG0488	(ABC) transporter
MC28_4918	COG0747	negative chemotaxis
MC28_4919	COG0601	transmembrane transport
MC28_4921	COG0444	Belongs to the ABC transporter superfamily
MC28_4922	COG4608	Belongs to the ABC transporter superfamily
MC28_4923	COG0561	phosphatase activity
MC28_4929	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MC28_4930	COG0179	Fumarylacetoacetate (FAA) hydrolase
MC28_4932	COG0531	amino acid
MC28_4933	COG2814	Major facilitator Superfamily
MC28_4935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MC28_4937	COG4294	response to UV
MC28_4938	COG0705	Rhomboid family
MC28_4940	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MC28_4941	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MC28_4942	COG0864	Transcriptional regulator
MC28_4943	COG2337	Toxic component of a toxin-antitoxin (TA) module
MC28_4944	COG2183	response to ionizing radiation
MC28_4946	COG0802	atpase or kinase
MC28_4947	COG1214	PFAM Peptidase M22, glycoprotease
MC28_4948	COG0456	acetyltransferase
MC28_4950	COG0488	(ABC) transporter
MC28_4953	COG1266	CAAX protease self-immunity
MC28_4963	COG1674	ftsk spoiiie
MC28_4965	COG2946	Replication initiation factor
MC28_4968	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MC28_4970	COG2252	PERMEase
MC28_4972	COG5002	protein histidine kinase activity
MC28_4974	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MC28_4977	COG2226	methyltransferase
MC28_4981	COG1215	transferase activity, transferring glycosyl groups
MC28_4982	COG0697	spore germination
MC28_4988	COG2205	protein histidine kinase activity
MC28_4989	COG0745	RESPONSE REGULATOR receiver
MC28_4995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_4997	COG1215	transferase activity, transferring glycosyl groups
MC28_4999	COG0697	spore germination
MC28_5003	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MC28_5004	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MC28_5006	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MC28_5009	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MC28_5012	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MC28_5014	COG0151	Belongs to the GarS family
MC28_5020	COG0210	DNA helicase
MC28_5022	COG4851	CamS sex pheromone cAM373 precursor
MC28_5025	COG1335	isochorismatase
MC28_5028	COG1464	Belongs to the NlpA lipoprotein family
MC28_5031	COG0003	Pfam Anion-transporting ATPase
MC28_5032	COG1846	Transcriptional regulator
MC28_5033	COG4682	membrane
MC28_5037	COG1597	lipid kinase activity
MC28_5038	COG0546	phosphoglycolate phosphatase activity
MC28_5039	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MC28_5041	COG1012	belongs to the aldehyde dehydrogenase family
MC28_5042	COG2076	Multidrug Resistance protein
MC28_5044	COG2309	aminopeptidase activity
MC28_5047	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_5049	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MC28_5050	COG5002	protein histidine kinase activity
MC28_5051	COG4807	Protein conserved in bacteria
MC28_5057	COG1473	amidohydrolase
MC28_5060	COG0450	alkyl hydroperoxide reductase
MC28_5061	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MC28_5063	COG0235	Class ii aldolase
MC28_5064	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_5065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_5066	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_5069	COG0166	Belongs to the GPI family
MC28_5074	COG5002	protein histidine kinase activity
MC28_5078	COG3541	Predicted nucleotidyltransferase
MC28_5079	COG2814	Major facilitator Superfamily
MC28_5080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MC28_5080	COG0723	plastoquinol--plastocyanin reductase activity
MC28_5082	COG0765	amino acid transport
MC28_5083	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_5085	COG0840	transmembrane signaling receptor activity
MC28_5090	COG0549	Belongs to the carbamate kinase family
MC28_5093	COG0277	FAD linked oxidase domain protein
MC28_5094	COG0366	Alpha amylase catalytic
MC28_5095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_5095	COG1263	PTS System
MC28_5095	COG2190	(PTS) system
MC28_5101	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MC28_5102	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
MC28_5106	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MC28_5108	COG1116	anion transmembrane transporter activity
MC28_5117	COG2270	Major facilitator Superfamily
MC28_5122	COG4193	domain, Protein
MC28_5124	COG2310	stress, protein
MC28_5125	COG2310	stress, protein
MC28_5126	COG2310	stress, protein
MC28_5127	COG0861	Integral membrane protein TerC family
MC28_5129	COG3853	Toxic anion resistance protein (TelA)
MC28_5132	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MC28_5134	COG1295	ribonuclease BN
MC28_5135	COG2217	Heavy metal translocating P-type atpase
MC28_5136	COG0697	spore germination
MC28_5140	COG0586	Pfam SNARE associated Golgi protein
MC28_5143	COG3871	stress protein (general stress protein 26)
MC28_5144	COG0387	Pfam Sodium calcium exchanger
MC28_5146	COG0535	radical SAM domain protein
MC28_5150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MC28_5151	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MC28_5152	COG0582	viral genome integration into host DNA
MC28_5166	COG1484	DNA-dependent DNA replication
MC28_5185	COG0582	viral genome integration into host DNA
MC28_5195	COG0740	serine-type endopeptidase activity
MC28_5208	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
MC28_5217	COG3829	transcription factor binding
MC28_5219	COG0833	amino acid
MC28_5220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MC28_5224	COG2066	Belongs to the glutaminase family
MC28_5226	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_5226	COG1263	PTS System
MC28_5227	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_5231	COG0463	Glycosyl transferase, family 2
MC28_5233	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MC28_5233	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_5234	COG0463	Glycosyl transferase, family 2
MC28_5235	COG1882	Formate acetyltransferase
MC28_5236	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
MC28_5241	COG1090	epimerase
MC28_5246	COG1988	membrane-bound metal-dependent
MC28_5247	COG1194	a g-specific adenine glycosylase
MC28_5252	COG1132	(ABC) transporter
MC28_5253	COG4129	membrane
MC28_5254	COG0067	glutamate synthase
MC28_5254	COG0070	glutamate synthase
MC28_5254	COG0069	glutamate synthase activity
MC28_5256	COG4555	ABC transporter
MC28_5260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MC28_5261	COG0735	belongs to the Fur family
MC28_5267	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
MC28_5268	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MC28_5272	COG5001	Diguanylate cyclase
MC28_5272	COG1716	ATPase activity
MC28_5273	COG2766	serine protein kinase
MC28_5278	COG1585	Membrane protein implicated in regulation of membrane protease activity
MC28_5279	COG2268	Band 7 protein
MC28_5281	COG3290	protein histidine kinase activity
MC28_5282	COG4565	transcriptional regulatory protein
MC28_5283	COG2851	Citrate transporter
MC28_5288	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MC28_5289	COG3842	ATPase activity
MC28_5294	COG0745	RESPONSE REGULATOR receiver
MC28_5295	COG5002	protein histidine kinase activity
MC28_5297	COG4990	cell redox homeostasis
MC28_5299	COG3290	protein histidine kinase activity
MC28_5300	COG4565	transcriptional regulatory protein
MC28_5301	COG3493	citrate carrier protein
MC28_5302	COG0281	malic enzyme
MC28_5304	COG0697	spore germination
MC28_5305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_5307	COG5002	protein histidine kinase activity
MC28_5308	COG0745	RESPONSE REGULATOR receiver
MC28_5311	COG0456	acetyltransferase
MC28_5311	COG0454	-acetyltransferase
MC28_5312	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MC28_5313	COG3383	formate dehydrogenase (NAD+) activity
MC28_5314	COG2427	Protein of unknown function (DUF1641)
MC28_5318	COG0531	amino acid
MC28_5321	COG0640	Transcriptional regulator
MC28_5322	COG2217	Heavy metal translocating P-type atpase
MC28_5323	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MC28_5326	COG3227	Zinc metalloprotease (Elastase)
MC28_5330	COG2720	vancomycin resistance protein
MC28_5331	COG1316	TRANSCRIPTIONal
MC28_5332	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MC28_5333	COG0346	lactoylglutathione lyase activity
MC28_5334	COG1253	flavin adenine dinucleotide binding
MC28_5335	COG1027	Aspartate ammonia-lyase
MC28_5336	COG1620	l-lactate permease
MC28_5339	COG3104	oligopeptide transport
MC28_5340	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_5341	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_5342	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MC28_5344	COG2226	methyltransferase
MC28_5346	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MC28_5348	COG4548	von Willebrand factor, type A
MC28_5349	COG0714	Associated with various cellular activities
MC28_5354	COG0531	amino acid
MC28_5355	COG2188	Transcriptional regulator
MC28_5356	COG1263	PTS System
MC28_5356	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MC28_5357	COG0366	Alpha amylase catalytic
MC28_5360	COG0697	spore germination
MC28_5361	COG4585	Histidine kinase
MC28_5362	COG2197	response regulator
MC28_5363	COG1404	Belongs to the peptidase S8 family
MC28_5365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MC28_5366	COG1115	amino acid carrier protein
MC28_5367	COG1126	abc transporter atp-binding protein
MC28_5368	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MC28_5369	COG0765	amino acid transport
MC28_5370	COG0765	amino acid transport
MC28_5371	COG0833	amino acid
MC28_5376	COG2378	regulation of single-species biofilm formation
MC28_5377	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MC28_5378	COG5002	protein histidine kinase activity
MC28_5381	COG0659	secondary active sulfate transmembrane transporter activity
MC28_5384	COG2271	Major facilitator Superfamily
MC28_5385	COG1846	Transcriptional regulator
MC28_5386	COG0477	Major facilitator Superfamily
MC28_5387	COG1609	Transcriptional regulator
MC28_5388	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MC28_5391	COG1172	Belongs to the binding-protein-dependent transport system permease family
MC28_5392	COG1879	ABC-type sugar transport system periplasmic component
MC28_5393	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MC28_5399	COG1063	alcohol dehydrogenase
MC28_5409	COG1388	LysM domain
MC28_5409	COG3584	3D domain protein
MC28_5410	COG1476	TRANSCRIPTIONal
MC28_5414	COG3104	oligopeptide transport
MC28_5416	COG1114	Component of the transport system for branched-chain amino acids
MC28_5419	COG1113	amino acid transport
MC28_5420	COG2252	PERMEase
MC28_5424	COG0475	glutathione-regulated potassium exporter activity
MC28_5424	COG0569	domain protein
MC28_5427	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MC28_5428	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MC28_5429	COG0833	amino acid
MC28_5430	COG4990	cell redox homeostasis
MC28_5433	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MC28_5434	COG0697	spore germination
MC28_5435	COG0531	amino acid
MC28_5438	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MC28_5439	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MC28_5440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MC28_5440	COG1918	ferrous iron import across plasma membrane
MC28_5441	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MC28_5442	COG0573	inorganic phosphate transmembrane transporter activity
MC28_5443	COG0581	inorganic phosphate transmembrane transporter activity
MC28_5444	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MC28_B02	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MC28_B03	COG4653	Phage capsid family
MC28_B27	COG0457	Tetratricopeptide repeat
MC28_B61	COG3331	DNA recombination
MC28_B67	COG0582	viral genome integration into host DNA
MC28_B70	COG5484	DNA packaging
MC28_B71	COG1783	phage Terminase large subunit
MC28_C002	COG3316	Transposase and inactivated derivatives
MC28_C016	COG0484	heat shock protein binding
MC28_C054	COG2002	toxin-antitoxin pair type II binding
MC28_C055	COG1923	regulation of RNA biosynthetic process
MC28_C065	COG0823	Involved in the tonB-independent uptake of proteins
MC28_C068	COG0823	Involved in the tonB-independent uptake of proteins
MC28_C075	COG3316	Transposase and inactivated derivatives
MC28_C077	COG1482	cell wall glycoprotein biosynthetic process
MC28_C080	COG2801	Transposase and inactivated derivatives
MC28_C089	COG0582	viral genome integration into host DNA
MC28_C091	COG3209	COG3209 Rhs family protein
MC28_C100	COG3316	Transposase and inactivated derivatives
MC28_D027	COG0741	lytic transglycosylase activity
MC28_D027	COG0791	NLP P60 protein
MC28_D048	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC28_D048	COG0551	DNA topoisomerase type I activity
MC28_D059	COG4974	Belongs to the 'phage' integrase family
MC28_D062	COG0758	DNA mediated transformation
MC28_D068	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MC28_D072	COG4166	transmembrane transport
MC28_D078	COG1192	Involved in chromosome partitioning
MC28_D127	COG0791	NLP P60 protein
MC28_D127	COG0741	lytic transglycosylase activity
MC28_D148	COG0551	DNA topoisomerase type I activity
MC28_D148	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MC28_D158	COG0457	Tetratricopeptide repeat
MC28_D164	COG3316	Transposase and inactivated derivatives
MC28_D167	COG3316	Transposase and inactivated derivatives
MC28_D180	COG4166	transmembrane transport
MC28_E020	COG1396	sequence-specific DNA binding
MC28_E042	COG3316	Transposase and inactivated derivatives
MC28_E065	COG0823	Involved in the tonB-independent uptake of proteins
MC28_E068	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MC28_E069	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MC28_E071	COG0823	Involved in the tonB-independent uptake of proteins
MC28_E079	COG0823	Involved in the tonB-independent uptake of proteins
MC28_E091	COG0697	spore germination
MC28_E103	COG1192	Involved in chromosome partitioning
MC28_E108	COG3344	reverse transcriptase
MC28_E117	COG1923	regulation of RNA biosynthetic process
MC28_E118	COG2002	toxin-antitoxin pair type II binding
MC28_E119	COG0697	spore germination
MC28_E120	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MC28_E121	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MC28_E123	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MC28_E138	COG0823	Involved in the tonB-independent uptake of proteins
MC28_E156	COG3568	Endonuclease Exonuclease Phosphatase
MC28_E158	COG0823	Involved in the tonB-independent uptake of proteins
MC28_E160	COG3316	Transposase and inactivated derivatives
MC28_E161	COG0582	viral genome integration into host DNA
MC28_E180	COG3883	PFAM NLP P60 protein
MC28_E180	COG0791	NLP P60 protein
MC28_E182	COG3344	reverse transcriptase
MC28_F010	COG3883	PFAM NLP P60 protein
MC28_F010	COG0791	NLP P60 protein
MC28_F012	COG3344	reverse transcriptase
MC28_F046	COG1012	belongs to the aldehyde dehydrogenase family
MC28_F046	COG1454	alcohol dehydrogenase
MC28_F050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MC28_F050	COG1328	CTP reductase activity
MC28_F054	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MC28_F055	COG1773	rubredoxin
MC28_F056	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MC28_F057	COG4990	cell redox homeostasis
MC28_F058	COG2116	formate transmembrane transporter activity
MC28_F061	COG0531	amino acid
MC28_F063	COG0531	amino acid
MC28_F065	COG1204	response to ionizing radiation
MC28_F075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MC28_F086	COG1404	Belongs to the peptidase S8 family
MC28_F089	COG1846	Transcriptional regulator
MC28_F089	COG0456	acetyltransferase
MC28_F093	COG2070	2-Nitropropane dioxygenase
MC28_F096	COG1136	(ABC) transporter
MC28_F106	COG3979	chitinase
MC28_F111	COG2376	Dihydroxyacetone kinase
MC28_F114	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_F115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MC28_F118	COG0517	IMP dehydrogenase activity
MC28_F118	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MC28_F119	COG1486	melibiose metabolic process
MC28_F121	COG3715	PTS system
MC28_F122	COG3716	PTS system mannose fructose sorbose family IID component
MC28_F127	COG1595	DNA-templated transcription, initiation
MC28_F132	COG1136	(ABC) transporter
MC28_F133	COG0577	efflux transmembrane transporter activity
MC28_F136	COG0741	lytic transglycosylase activity
MC28_F137	COG0772	Belongs to the SEDS family
MC28_F139	COG3850	Histidine kinase
MC28_F139	COG5002	protein histidine kinase activity
MC28_F140	COG0745	RESPONSE REGULATOR receiver
MC28_F151	COG1349	DNA-binding transcription factor activity
MC28_F152	COG0577	efflux transmembrane transporter activity
MC28_F169	COG0697	spore germination
MC28_F171	COG1114	Component of the transport system for branched-chain amino acids
MC28_F172	COG1115	amino acid carrier protein
MC28_F173	COG2066	Belongs to the glutaminase family
MC28_F179	COG3754	Rhamnan synthesis protein F
MC28_F180	COG1131	(ABC) transporter
MC28_F181	COG0842	Transport permease protein
MC28_F184	COG1028	Short-chain dehydrogenase reductase Sdr
MC28_F185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MC28_F186	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MC28_F189	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MC28_F190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MC28_F194	COG1091	dTDP-4-dehydrorhamnose reductase activity
MC28_F212	COG1131	(ABC) transporter
MC28_F217	COG0662	Cupin 2, conserved barrel domain protein
MC28_F218	COG2207	Transcriptional regulator
MC28_F218	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MC28_F223	COG1136	(ABC) transporter
MC28_F225	COG5002	protein histidine kinase activity
MC28_F226	COG0577	efflux transmembrane transporter activity
MC28_F228	COG0577	efflux transmembrane transporter activity
MC28_F229	COG1136	(ABC) transporter
MC28_F233	COG1482	cell wall glycoprotein biosynthetic process
MC28_F234	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC28_F234	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MC28_F234	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_F235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MC28_F235	COG3711	transcriptional antiterminator
MC28_F240	COG0791	NLP P60 protein
MC28_F250	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MC28_F254	COG0659	secondary active sulfate transmembrane transporter activity
MC28_F257	COG2824	Alkylphosphonate utilization operon protein PhnA
MC28_F258	COG2807	transmembrane transport
MC28_F259	COG2258	MOSC domain
MC28_F260	COG2186	Transcriptional regulator
MC28_F262	COG1476	TRANSCRIPTIONal
MC28_F274	COG2732	(Barnase) inhibitor
MC28_F276	COG0582	viral genome integration into host DNA
MC28_G003	COG1401	restriction endodeoxyribonuclease activity
MC28_G003	COG1401	restriction endodeoxyribonuclease activity
MC28_G005	COG2003	Belongs to the UPF0758 family
MC28_G006	COG1609	Transcriptional regulator
MC28_G007	COG2814	Major facilitator Superfamily
MC28_G008	COG0673	inositol 2-dehydrogenase activity
MC28_G013	COG0191	fructose-bisphosphate aldolase activity
MC28_G014	COG3718	enzyme involved in inositol metabolism
MC28_G016	COG0772	Belongs to the SEDS family
MC28_G018	COG0457	Tetratricopeptide repeat
MC28_G025	COG3104	oligopeptide transport
MC28_G034	COG0457	Tetratricopeptide repeat
MC28_G035	COG0463	Glycosyl transferase, family 2
MC28_G036	COG0463	Glycosyl transferase, family 2
MC28_G037	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MC28_G038	COG1088	dTDP-glucose 4,6-dehydratase activity
MC28_G039	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MC28_G040	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
MC28_G043	COG2089	acid synthase
MC28_G048	COG4641	Protein conserved in bacteria
MC28_G052	COG1252	NADH dehydrogenase
MC28_G053	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MC28_G053	COG0425	Belongs to the sulfur carrier protein TusA family
MC28_G061	COG0318	PFAM AMP-dependent synthetase and ligase
MC28_G063	COG0833	amino acid
MC28_G064	COG2040	homocysteine
MC28_G066	COG2259	Doxx family
MC28_G068	COG4990	cell redox homeostasis
MC28_G069	COG0745	RESPONSE REGULATOR receiver
MC28_G070	COG5002	protein histidine kinase activity
MC28_G073	COG1846	Transcriptional regulator
MC28_G077	COG4974	Belongs to the 'phage' integrase family
MC28_G078	COG1760	l-serine dehydratase
MC28_G079	COG0156	8-amino-7-oxononanoate synthase activity
MC28_G082	COG0583	DNA-binding transcription factor activity
MC28_G083	COG2814	Major facilitator Superfamily
MC28_G085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MC28_G090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MC28_G097	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MC28_G100	COG3620	sequence-specific DNA binding
MC28_G102	COG5444	nuclease activity
MC28_G107	COG2732	(Barnase) inhibitor
MC28_G118	COG2184	nucleotidyltransferase activity
MC28_G135	COG0577	efflux transmembrane transporter activity
MC28_G136	COG1136	(ABC) transporter
MC28_G137	COG5002	protein histidine kinase activity
MC28_G142	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MC28_G142	COG4499	WXG100 protein secretion system (Wss), protein YukC
MC28_G144	COG0577	efflux transmembrane transporter activity
MC28_G145	COG1136	(ABC) transporter
MC28_G146	COG2205	protein histidine kinase activity
MC28_G147	COG0745	RESPONSE REGULATOR receiver
MC28_G149	COG1378	Sugar-specific transcriptional regulator TrmB
MC28_G150	COG1396	sequence-specific DNA binding
MC28_G160	COG0726	polysaccharide deacetylase
MC28_G161	COG5002	protein histidine kinase activity
MC28_G163	COG0789	Transcriptional regulator
MC28_G164	COG0577	efflux transmembrane transporter activity
MC28_G165	COG1136	(ABC) transporter
MC28_G167	COG2205	protein histidine kinase activity
MC28_G171	COG1073	alpha beta
MC28_G177	COG0583	DNA-binding transcription factor activity
MC28_G182	COG0584	glycerophosphoryl diester phosphodiesterase
MC28_G190	COG0456	acetyltransferase
MC28_G192	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MC28_G194	COG0010	Belongs to the arginase family
MC28_G196	COG0662	Cupin 2, conserved barrel domain protein
MC28_G197	COG1999	signal sequence binding
MC28_G238	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MC28_G254	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MC28_G266	COG0741	lytic transglycosylase activity
MC28_G266	COG0791	NLP P60 protein
MC28_G289	COG0741	lytic transglycosylase activity
MC28_G290	COG5002	protein histidine kinase activity
MC28_G291	COG0745	RESPONSE REGULATOR receiver
MC28_G293	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MC28_G294	COG0577	efflux transmembrane transporter activity
MC28_G295	COG1136	(ABC) transporter
MC28_G297	COG1404	Belongs to the peptidase S8 family
MC28_G305	COG1309	transcriptional regulator
MC28_G306	COG2814	Major facilitator Superfamily
MC28_G313	COG0457	Tetratricopeptide repeat
MC28_G327	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MC28_G330	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MC28_G343	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MC28_G367	COG5632	N-Acetylmuramoyl-L-alanine amidase
MC28_G381	COG0494	nUDIX hydrolase
MC28_G388	COG0494	nUDIX hydrolase
MC28_G411	COG0582	viral genome integration into host DNA