locus-tag class description BT246_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BT246_00030 ENOG410848D S4 domain protein YaaA BT246_00060 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BT246_00130 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BT246_00160 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BT246_00210 ENOG4105ZMH deoxynucleoside kinase BT246_00230 ENOG4105GTG Isochorismatase BT246_00240 ENOG4108Z6B deaminase BT246_00260 ENOG4105C6E dna polymerase iii BT246_00300 ENOG41067KS pro-sigma K processing BT246_00370 ENOG4105CXN decarboxylase BT246_00390 ENOG4105FA2 dna polymerase iii BT246_00400 ENOG4105MA4 psp1 domain protein BT246_00420 ENOG41060K3 Methyltransferase BT246_00440 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BT246_00450 ENOG4105KRN Transcriptional regulator, abrb family BT246_00460 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BT246_00470 ENOG4105F8V Hydrolase, tatD family BT246_00480 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BT246_00500 ENOG4105XFA sporulation peptidase YabG BT246_00510 ENOG4105W42 Veg protein BT246_00540 ENOG4105DFT pur operon repressor BT246_00550 ENOG4105KME endoribonuclease L-psp BT246_00580 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BT246_00590 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BT246_00610 ENOG4108JA2 transcriptioN-repair coupling factor BT246_00620 ENOG4108M14 stage v sporulation protein t BT246_00640 ENOG4108IY2 MazG family BT246_00650 ENOG41082I2 s4 domain protein BT246_00660 ENOG4105VYY sporulation protein yabp BT246_00690 ENOG41060GV RNA binding s1 domain protein BT246_00730 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BT246_00740 ENOG4108UGV hypoxanthine phosphoribosyltransferase BT246_00750 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BT246_00780 ENOG4105C6T cysteine synthase BT246_00790 ENOG4105CRQ synthase (Component I) BT246_00800 ENOG4105DDQ anthranilate synthase BT246_00810 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BT246_00820 ENOG4105EEI dihydropteroate synthase BT246_00830 ENOG4105KRF dihydroneopterin aldolase BT246_00840 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BT246_00860 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BT246_01040 ENOG4108Z0C Uvrb UvrC protein BT246_01070 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BT246_01090 ENOG4105CTP PilT protein domain protein BT246_01130 ENOG4105D7W serine acetyltransferase BT246_01160 ENOG4105C2N RNA methyltransferase TrmH family group 3 BT246_01170 ENOG4105M0M Tetracycline resistance protein BT246_01180 ENOG4105QIV RNA polymerase BT246_01200 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BT246_01240 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BT246_01250 ENOG4107Y49 methyltransferase BT246_01270 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BT246_01280 ENOG4105XPM ribosomal protein BT246_01490 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BT246_01540 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BT246_01560 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BT246_01580 ENOG41067V7 50S ribosomal protein L36 BT246_01630 ENOG4108JJB ABC transporter BT246_01640 ENOG4108JJB ABC transporter BT246_01650 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BT246_01660 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BT246_01710 ENOG4105D1F ATP-binding protein BT246_01740 ENOG4108NMV polysaccharide deacetylase BT246_01900 ENOG4105C8B TIGR00159 family BT246_01910 ENOG4107U5W ybbr family BT246_01940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BT246_01990 ENOG4108PSK reductase BT246_02000 ENOG4108UMI ABC transporter, permease BT246_02010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BT246_02020 ENOG4105D01 (LipO)protein BT246_02030 ENOG4105CB2 alcohol dehydrogenase BT246_02070 ENOG4105IQ5 FAD linked oxidase domain protein BT246_02110 ENOG4105C2C drug resistance transporter, Bcr CflA BT246_02150 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BT246_02160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BT246_02170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BT246_02180 ENOG4105C3U ABC transporter BT246_02190 ENOG4108JQ7 (ABC) transporter BT246_02240 ENOG4108J59 Extracellular solute-binding protein, family 5 BT246_02250 ENOG4108J59 Extracellular solute-binding protein, family 5 BT246_02280 ENOG4106Z1T Nicotinamide Mononucleotide Transporter BT246_02300 ENOG4105E0C molybdate abc transporter BT246_02310 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BT246_02320 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BT246_02350 ENOG4105EGI Transcriptional regulator BT246_02400 ENOG4105F6E Acyl-transferase BT246_02440 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BT246_02480 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BT246_02530 ENOG4105C5H ABC transporter BT246_02550 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BT246_02570 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BT246_02580 ENOG4105C3U ABC transporter BT246_02590 ENOG4108JQ7 (ABC) transporter BT246_02600 ENOG410667J hydrolase BT246_02660 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase BT246_02670 ENOG4105ERH Fumarylacetoacetate hydrolase BT246_02690 ENOG4105CUB amino acid BT246_02700 ENOG4108SC4 )-transporter BT246_02710 ENOG4105CPF Cell wall formation (By similarity) BT246_02720 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BT246_02770 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BT246_02780 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BT246_02800 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BT246_03000 ENOG4105K8N protein family UPF0079, ATPase BT246_03010 ENOG41072GX Peptidase M22 Glycoprotease BT246_03020 ENOG410801F ribosomal-protein-alanine acetyltransferase BT246_03030 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BT246_03040 ENOG4105C5H ABC transporter BT246_03070 ENOG4108TYN CAAX amino terminal protease family protein BT246_03110 ENOG4105C7N Xanthine uracil vitamin C permease BT246_03130 ENOG4105BZU Histidine kinase BT246_03180 ENOG4107ZXU DSBA oxidoreductase BT246_03220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BT246_03270 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BT246_03280 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BT246_03290 ENOG4105C83 adenylosuccinate lyase BT246_03310 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BT246_03360 ENOG4108V3E phosphoribosylglycinamide formyltransferase BT246_03380 ENOG4105C12 Phosphoribosylglycinamide synthetase BT246_03420 ENOG4105EGI Transcriptional regulator BT246_03470 ENOG4105C4R Atp-dependent dna helicase BT246_03480 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BT246_03520 ENOG4108W2Y isochorismatase BT246_03530 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BT246_03540 ENOG4108UMI ABC transporter, permease BT246_03550 ENOG4105D01 (LipO)protein BT246_03590 ENOG410834F Transcriptional regulator BT246_03600 ENOG4107I77 yiaA/B two helix domain BT246_03640 ENOG4105CBD Diacylglycerol kinase BT246_03660 ENOG4108JPW Aminotransferase BT246_03680 ENOG4105C26 Dehydrogenase BT246_03690 ENOG4105KPY Small multidrug resistance protein BT246_03870 ENOG4108NF7 phage-type endonuclease BT246_03890 ENOG4108PNI recT protein BT246_03910 ENOG4105CDU Replicative dna helicase BT246_03970 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_04020 ENOG4105WXW Antirepressor BT246_04280 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BT246_04370 ENOG4105D9N nucleoside BT246_04380 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BT246_04390 ENOG4105VTR Integrase BT246_04530 ENOG4105YQ0 BT246_04550 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BT246_04570 ENOG4105KRN Transcriptional regulator, abrb family BT246_04940 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BT246_05010 ENOG4108W15 Protein of unknown function (DUF1456) BT246_05040 ENOG4105DTQ mandelate racemase muconate lactonizing BT246_05060 ENOG4105DFD Na H antiporter BT246_05100 ENOG4105D3R alkyl hydroperoxide reductase BT246_05110 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BT246_05120 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BT246_05130 ENOG4107W7X Aldolase BT246_05140 ENOG4105EHG Permease protein BT246_05150 ENOG4105DQ5 transport system permease protein BT246_05160 ENOG4108V5C ABC transporter BT246_05170 ENOG4105CAY ferredoxin--nadp reductase BT246_05200 ENOG4106UIA BT246_05210 ENOG4106UIA BT246_05240 ENOG4105BZU Histidine kinase BT246_05280 ENOG410756H nucleotidyltransferase BT246_05290 ENOG4105D2S major facilitator superfamily BT246_05320 ENOG4105E5Q amino acid AbC transporter BT246_05330 ENOG4105EAB amino acid AbC transporter BT246_05360 ENOG4105C8Q Methyl-accepting chemotaxis BT246_05390 ENOG4105DBV ornithine carbamoyltransferase BT246_05410 ENOG4105C5B carbamate kinase BT246_05420 ENOG4108W63 CRP FNR family transcriptional regulator BT246_05440 ENOG4105DNP FAD linked oxidase domain protein BT246_05460 ENOG4105CI1 PTS System BT246_05490 ENOG4105C9U ATP-dependent DNA helicase RecQ BT246_05520 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BT246_05580 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BT246_05610 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component BT246_05620 ENOG4105D2X ABC transporter substrate-binding protein BT246_05650 ENOG4105C5H ABC transporter BT246_05710 ENOG41062JF Transcriptional regulator BT246_05740 ENOG4105DEU major facilitator superfamily BT246_05770 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BT246_05800 ENOG4108N0M stress protein BT246_05810 ENOG4106FN3 tellurium resistance protein BT246_05820 ENOG4106FN3 tellurium resistance protein BT246_05830 ENOG4107TS3 membrane protein, TerC BT246_05840 ENOG4108TTB tellurium resistance protein BT246_05870 ENOG41068PA UPF0435 protein BT246_05880 ENOG4105KJF protein tyrosine phosphatase BT246_05900 ENOG4107U9T Pfam:Ribonuclease_BN BT246_05910 ENOG4105C59 p-type ATPase BT246_05920 ENOG4108IPJ Membrane BT246_05960 ENOG4107ZTW SNARE associated Golgi BT246_05990 ENOG410606W general stress protein BT246_06000 ENOG4105UPD Calcium Proton BT246_06070 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BT246_06080 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BT246_06100 ENOG4108JUB Transcriptional regulator BT246_06120 ENOG4108IQI permease BT246_06200 ENOG4108A04 Beta-lactamase BT246_06230 ENOG4107R51 Glycosyl transferase, family 2 BT246_06240 ENOG4107QQG Dehydrogenase BT246_06250 ENOG4105C3I Nad-dependent epimerase dehydratase BT246_06260 ENOG4105CKK Glycosyl transferase, family 2 BT246_06280 ENOG4105F1A Pyruvate formate-lyase BT246_06320 ENOG4105CI2 imidazolone-5-propionate hydrolase BT246_06330 ENOG4105ECP epimerase BT246_06390 ENOG41067AE Membrane-bound metal-dependent hydrolase BT246_06400 ENOG4105CEN a g-specific adenine glycosylase BT246_06410 ENOG4106BXE BT246_06450 ENOG4105BZ1 (ABC) transporter BT246_06460 ENOG4107NBY Membrane BT246_06470 ENOG4105CBC glutamate synthase BT246_06490 ENOG4108IUW ABC transporter BT246_06530 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BT246_06540 ENOG4105G5W regulator Fur family BT246_06780 ENOG4108JQC penicillin-binding protein 1A BT246_06790 ENOG4108R9S DSBA oxidoreductase BT246_06810 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BT246_06830 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BT246_06860 ENOG4105CYN Serine protein kinase BT246_06930 ENOG4105C94 Transporter BT246_06950 ENOG4105VTR Integrase BT246_07370 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BT246_07430 ENOG4105DZ6 Band 7 protein BT246_07450 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BT246_07460 ENOG4108V9W transcriptional regulatory protein BT246_07470 ENOG4105D4T Citrate transporter BT246_07540 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BT246_07550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BT246_07560 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BT246_07570 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component BT246_07580 ENOG4105BZ7 extracellular solute-binding protein family 1 BT246_07590 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BT246_07600 ENOG4108STX response regulator BT246_07610 ENOG4105US7 Histidine kinase BT246_07660 ENOG4108MRH transcriptional regulatory protein BT246_07680 ENOG4105C6K Malic enzyme BT246_07700 ENOG4108UZ3 Transporter BT246_07710 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BT246_07730 ENOG4105BZU Histidine kinase BT246_07740 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_07770 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BT246_07780 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BT246_07790 ENOG4108JB9 formate dehydrogenase BT246_07830 ENOG4105CUB amino acid BT246_07850 ENOG4105C59 p-type ATPase BT246_07860 ENOG4105DAP Nicotinate phosphoribosyltransferase BT246_07940 ENOG41073R8 VanW family BT246_07950 ENOG4108KGH TRANSCRIPTIONal BT246_07960 ENOG4105D9N nucleoside BT246_07970 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BT246_07980 ENOG4105C37 (CBS) domain BT246_07990 ENOG4108IJ0 Aspartate ammonia-lyase BT246_08000 ENOG4105DAA L-lactate BT246_08030 ENOG4105DUX Transporter BT246_08040 ENOG4108MES Periplasmic binding protein BT246_08050 ENOG4105DQ5 transport system permease protein BT246_08060 ENOG4108IHU transport system permease protein BT246_08070 ENOG4105E0A ABC, transporter BT246_08100 ENOG4105EXW epimerase dehydratase BT246_08120 ENOG4107T89 von Willebrand factor, type A BT246_08130 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BT246_08140 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BT246_08160 ENOG4105BZU Histidine kinase BT246_08170 ENOG4105D5Q Arginine ornithine antiporter BT246_08180 ENOG4107414 GntR family transcriptional regulator BT246_08190 ENOG4105C5Y PTS System BT246_08200 ENOG4105CG3 alpha amylase, catalytic region BT246_08230 ENOG4105E1K spore germination protein BT246_08240 ENOG4105CRN Aminoglycoside phosphotransferase BT246_08250 ENOG4105BZG amino acid carrier protein BT246_08260 ENOG4105CDA abc transporter atp-binding protein BT246_08270 ENOG4105CT1 (ABC) transporter BT246_08280 ENOG4105EAD ABC transporter BT246_08290 ENOG4105DRP amino acid AbC transporter BT246_08300 ENOG4108IQI permease BT246_08330 ENOG4105GFR rna polymerase sigma factor BT246_08350 ENOG4105D29 Helix-turn-helix type 11 domain protein BT246_08360 ENOG4105NAE bifunctional deaminase-reductase domain protein BT246_08370 ENOG4105BZU Histidine kinase BT246_08410 ENOG4105CHH sulfate transporter BT246_08420 ENOG41068KF Universal stress protein BT246_08460 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BT246_08480 ENOG4108JQ7 (ABC) transporter BT246_08500 ENOG4105CXY transporter BT246_08510 ENOG41067TZ transcriptional regulator, MarR family BT246_08520 ENOG4105C0R drug resistance transporter emrb qaca subfamily BT246_08530 ENOG4105ETE Transcriptional regulator (LacI family BT246_08540 ENOG4108RVA ribokinase BT246_08560 ENOG4105C2J ABC transporter BT246_08570 ENOG4105CNN ABC, transporter BT246_08580 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BT246_08590 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BT246_08660 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) BT246_08730 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BT246_08740 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BT246_08750 ENOG41069ER domain protein BT246_08760 ENOG4105VZ8 Transcriptional regulator BT246_08800 ENOG4107D63 BT246_08830 ENOG4105DUX Transporter BT246_08870 ENOG4105C85 amino acid BT246_08880 ENOG4105C7N Xanthine uracil vitamin C permease BT246_08910 ENOG4105MA6 gCN5-related N-acetyltransferase BT246_08950 ENOG4105CCU oxidase (Subunit III) BT246_08960 ENOG4105BZ9 Cytochrome C oxidase, subunit I BT246_08970 ENOG4105E2S oxidase) subunit II BT246_09020 ENOG4106CAD Protein of unknown function (DUF3311) BT246_09030 ENOG4105E1V na solute symporter BT246_09060 ENOG4108NHD germination protein BT246_09070 ENOG4105CE1 Ferrous iron transport protein b BT246_09080 ENOG4105CE1 Ferrous iron transport protein b BT246_09090 ENOG4105CE1 Ferrous iron transport protein b BT246_09100 ENOG4105CVA phosphate BT246_09110 ENOG4105C8U phosphate abc transporter BT246_09120 ENOG4105E2Z phosphate ABC transporter (Permease BT246_09410 ENOG41080XQ Signal transduction protein with cbs domains BT246_09450 ENOG4105ETU transcriptional activator (TenA BT246_09470 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BT246_09490 ENOG4108VEU Thiamine monophosphate synthase BT246_09500 ENOG41080HI glycine oxidase BT246_09530 ENOG4105D06 uba thif-type nad fad binding protein BT246_09540 ENOG4105DWF phosphomethylpyrimidine kinase BT246_09600 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BT246_09630 ENOG4108INS Transcriptional regulator BT246_09660 ENOG4105C7N Xanthine uracil vitamin C permease BT246_09680 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BT246_09710 ENOG4105K63 Thioredoxin BT246_09750 ENOG4108B31 Spore germination protein BT246_09790 ENOG4107Y03 Nitroreductase BT246_09800 ENOG4105ED1 spovr family BT246_09820 ENOG4105J4Q Transcriptional regulator BT246_09850 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BT246_09860 ENOG4105XTG Pfam:DUF156 BT246_09870 ENOG4105VFE sira family BT246_09880 ENOG4107TPS domain protein BT246_09890 ENOG4105VFE sira family BT246_09900 ENOG41085GJ domain protein BT246_09920 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BT246_09930 ENOG41087NI Sulfite exporter TauE/SafE BT246_09950 ENOG4108KGH TRANSCRIPTIONal BT246_10000 ENOG41069ER domain protein BT246_10010 ENOG4107RBB ABC transporter, permease BT246_10020 ENOG4105C19 ABC transporter BT246_10080 ENOG4105WEF catalase BT246_10150 ENOG4107T5V SNARE associated Golgi BT246_10220 ENOG4105CUB amino acid BT246_10230 ENOG4107RWR Sodium hydrogen exchanger BT246_10250 ENOG4106KNT transcriptional regulator BT246_10340 ENOG4108YXU transcriptional regulator AsnC family BT246_10350 ENOG4105CH7 arginosuccinase BT246_10360 ENOG4105UBK short-chain dehydrogenase reductase BT246_10380 ENOG4105KPY Small multidrug resistance protein BT246_10460 ENOG4107RKG DJ-1/PfpI family BT246_10470 ENOG4105CH6 catalase BT246_10490 ENOG4105D5Q Arginine ornithine antiporter BT246_10510 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BT246_10530 ENOG4105C26 Dehydrogenase BT246_10540 ENOG4105BZ1 (ABC) transporter BT246_10550 ENOG4105BZ1 (ABC) transporter BT246_10570 ENOG4105DRP amino acid AbC transporter BT246_10580 ENOG4105CDA abc transporter atp-binding protein BT246_10610 ENOG410839P BT246_10640 ENOG4108UH6 UPF0754 membrane protein BT246_10740 ENOG4107FQX Alpha-acetolactate decarboxylase BT246_10800 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BT246_10810 ENOG4105D4P Coproporphyrinogen iii oxidase BT246_10820 ENOG4105CEY Amp-dependent synthetase and ligase BT246_10850 ENOG4105CHH sulfate transporter BT246_10900 ENOG4105CGU Enoyl-CoA hydratase BT246_10940 ENOG4105DER m42 family BT246_10980 ENOG4105CTU Proline racemase BT246_10990 ENOG4105CIF Ornithine Cyclodeaminase BT246_11040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BT246_11060 ENOG4108JQ7 (ABC) transporter BT246_11170 ENOG4105CSH Transporter BT246_11190 ENOG4108MRH transcriptional regulatory protein BT246_11250 ENOG4105CDU Replicative dna helicase BT246_11320 ENOG4105C0R drug resistance transporter emrb qaca subfamily BT246_11380 ENOG4105F6J Alpha beta hydrolase fold BT246_11490 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BT246_11510 ENOG4105F27 Major Facilitator BT246_11520 ENOG4105WAB arsR family transcriptional regulator BT246_11540 ENOG4105CMT Dihydroxyacetone kinase BT246_11560 ENOG4105CMT Dihydroxyacetone kinase BT246_11730 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BT246_11810 ENOG4105WN5 stage II sporulation protein BT246_11830 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_11850 ENOG4108MJI response regulator BT246_11860 ENOG4105BZU Histidine kinase BT246_11870 ENOG4105BZU Histidine kinase BT246_11960 ENOG4107QHE Choloylglycine hydrolase BT246_12000 ENOG4107VRP DNA repair exonuclease BT246_12010 ENOG4106D4I domain protein BT246_12040 ENOG410829K Lysine exporter protein (Lyse ygga) BT246_12090 ENOG4108MUZ hydrolase BT246_12120 ENOG4105F0F Oxalate decarboxylase BT246_12130 ENOG41067QW Transcriptional regulator BT246_12140 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BT246_12170 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BT246_12190 ENOG4105DU6 RNA polymerase BT246_12210 ENOG4105CNI cell division protein FtsW BT246_12220 ENOG4105EEM helicase BT246_12240 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BT246_12290 ENOG4105K59 histidine triad (HIT) protein BT246_12350 ENOG410905X membrane-flanked domain protein BT246_12360 ENOG4105CKV Membrane BT246_12430 ENOG4105EKQ RNA-directed DNA polymerase BT246_12510 ENOG410905X membrane-flanked domain protein BT246_12520 ENOG4105CKV Membrane BT246_12530 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BT246_12540 ENOG4105BZ4 penicillin-binding protein BT246_12560 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BT246_12570 ENOG4105C1Q protoporphyrinogen oxidase BT246_12620 ENOG4105NA0 Transcriptional regulator BT246_12650 ENOG4105ECB domain protein BT246_12650 ENOG4105ECB domain protein BT246_12720 ENOG4106AXD BT246_12730 ENOG4108RQ5 Beta-lactamase domain-containing protein BT246_12740 ENOG4105DF9 Lipoate-protein, ligase BT246_12760 ENOG4105CEY Amp-dependent synthetase and ligase BT246_12780 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BT246_12790 ENOG4108I5D sulfate abc transporter BT246_12800 ENOG4105ECW sulfate abc transporter BT246_12810 ENOG4108IJ6 ABC transporter BT246_12850 ENOG4105CNA YD repeat protein BT246_12860 ENOG4105CNA YD repeat protein BT246_12970 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BT246_12980 ENOG4107RN3 metallophosphoesterase BT246_12990 ENOG4107TVP HD domain protein BT246_13010 ENOG4108AEY RNA polymerase sigma factor BT246_13020 ENOG41086D8 Transcriptional regulator BT246_13050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BT246_13100 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BT246_13110 ENOG4105C8Q Methyl-accepting chemotaxis BT246_13120 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) BT246_13140 ENOG4107QP3 malate synthase g BT246_13180 ENOG4105VEQ Cold shock protein BT246_13260 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BT246_13270 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BT246_13350 ENOG4105ERH Fumarylacetoacetate hydrolase BT246_13370 ENOG4105C8Y Acetylornithine aminotransferase BT246_13400 ENOG4105CAQ asparagine synthetase BT246_13430 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BT246_13630 ENOG4105DQ6 Transposase BT246_13830 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BT246_13870 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BT246_13880 ENOG4105CH6 catalase BT246_13890 ENOG4105BZU Histidine kinase BT246_13930 ENOG4105QNR S1 RNA binding domain protein BT246_13940 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BT246_13960 ENOG4107AYK membrAne BT246_13970 ENOG41073B9 BT246_13990 ENOG4108KP7 hydrolase BT246_14010 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BT246_14060 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BT246_14070 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BT246_14100 ENOG4105C31 Tryptophanyl-tRNA synthetase BT246_14140 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BT246_14150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BT246_14170 ENOG4108JQ7 (ABC) transporter BT246_14180 ENOG4105UQX Mate efflux family protein BT246_14220 ENOG4108ZCF integral membrane protein BT246_14240 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BT246_14260 ENOG4105DPN Oligoendopeptidase f BT246_14290 ENOG4108Z18 K06886 hemoglobin BT246_14300 ENOG4105MIX Adenylate cyclase BT246_14310 ENOG4106EFP UPF0738 protein BT246_14330 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BT246_14340 ENOG4105EMS pseudouridine synthase BT246_14380 ENOG4105K64 Glycosyl transferase, family 2 BT246_14420 ENOG4107TVC Glycosyl transferase, family 2 BT246_14470 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BT246_14480 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BT246_14500 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BT246_14640 ENOG4105CK7 Sodium proline symporter BT246_14670 ENOG4105CRQ synthase (Component I) BT246_14680 ENOG4105DDQ anthranilate synthase BT246_14700 ENOG4105DK0 Indole-3-glycerol phosphate synthase BT246_14710 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BT246_14720 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BT246_14730 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BT246_14850 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BT246_14890 ENOG4105C7S Dehydrogenase BT246_14910 ENOG4105VZ8 Transcriptional regulator BT246_14970 ENOG4108IUX (ABC) transporter BT246_14980 ENOG4105RHA ABC transporter, permease BT246_15020 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BT246_15040 ENOG4105DZ1 carboxypeptidase BT246_15050 ENOG4105VFR signal peptidase BT246_15120 ENOG4105C26 Dehydrogenase BT246_15130 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BT246_15140 ENOG4105F38 ABC transporter, permease BT246_15150 ENOG4105D38 putrescine abc transporter BT246_15160 ENOG4107RUE extracellular solute-binding protein family 1 BT246_15180 ENOG4105EYF MMPL domain protein BT246_15200 ENOG4108YBP pseudouridine synthase BT246_15220 ENOG4105K4I Scp-like extracellular BT246_15230 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BT246_15240 ENOG4105CQB FAD linked oxidase domain protein BT246_15270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_15280 ENOG4105BZU Histidine kinase BT246_15290 ENOG4105JXH GntR family transcriptional regulator BT246_15330 ENOG4106A3R peptidase BT246_15350 ENOG4108QTI )-transporter BT246_15360 ENOG4107TS3 membrane protein, TerC BT246_15370 ENOG4105CZN Potassium uptake protein BT246_15380 ENOG410681C small acid-soluble spore protein BT246_15390 ENOG4108Z7G MaoC domain protein dehydratase BT246_15430 ENOG4105CHR reductase BT246_15490 ENOG4105C4Y ABC transporter BT246_15500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BT246_15510 ENOG4107RCV ABC transporter, permease BT246_15550 ENOG4105E98 transcriptional regulator DeoR family BT246_15580 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BT246_15600 ENOG4105PXI polysaccharide deacetylase BT246_15620 ENOG4105BZU Histidine kinase BT246_15630 ENOG41090MY MarR family Transcriptional regulator BT246_15650 ENOG4106DF1 BT246_15670 ENOG4105BZU Histidine kinase BT246_15680 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BT246_15690 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BT246_15700 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BT246_15780 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BT246_15790 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BT246_15800 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BT246_15810 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BT246_15820 ENOG4105CZV ABC transporter BT246_15840 ENOG4105CJ1 ABC, transporter BT246_15920 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BT246_15930 ENOG4105EA8 2-Nitropropane dioxygenase BT246_15940 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BT246_15960 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BT246_16010 ENOG4105NQC Flavodoxin BT246_16120 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BT246_16180 ENOG4105CZN Potassium uptake protein BT246_16190 ENOG41063Y9 BT246_16200 ENOG4105KBJ sporulation protein ytfj BT246_16240 ENOG4105CM2 brancheD-chain amino acid aminotransferase BT246_16260 ENOG4105C7K acetolactate synthase BT246_16270 ENOG4108ZP8 Acetolactate synthase small subunit BT246_16280 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BT246_16310 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BT246_16350 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BT246_16360 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BT246_16370 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BT246_16380 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BT246_16420 ENOG4107RVV histidinol phosphate phosphatase, hisj family BT246_16450 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BT246_16460 ENOG4105E0M Sulfatase BT246_16490 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BT246_16530 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BT246_16540 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BT246_16560 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BT246_16570 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BT246_16580 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BT246_16600 ENOG4105C8J )-transporter BT246_16650 ENOG4105DFD Na H antiporter BT246_16690 ENOG4105ENE Histidine kinase BT246_16700 ENOG4105WH1 Two component transcriptional regulator luxr family BT246_16750 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BT246_16800 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BT246_16840 ENOG4105CJ3 phosphate transporter BT246_16850 ENOG4107GRR phosphate transport regulator BT246_16860 ENOG4105BZ4 penicillin-binding protein BT246_16890 ENOG4105BZU Histidine kinase BT246_16900 ENOG4105I3N Conserved Protein BT246_16930 ENOG4105BZU Histidine kinase BT246_16990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BT246_17000 ENOG4105DZ1 carboxypeptidase BT246_17010 ENOG4108JIC nucleoside recognition domain protein BT246_17030 ENOG4105FE9 pseudouridine synthase BT246_17040 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BT246_17050 ENOG4107TWT Cytochrome c biogenesis protein BT246_17060 ENOG4105CRE cytochrome C BT246_17070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_17080 ENOG4105BZU Histidine kinase BT246_17090 ENOG4108WBT adenosyltransferase BT246_17130 ENOG4108SAX Membrane BT246_17160 ENOG4105C9U ATP-dependent DNA helicase RecQ BT246_17170 ENOG4105I7S Abortive infection protein BT246_17190 ENOG4107RGJ metallophosphoesterase BT246_17200 ENOG4108XDN Transcriptional regulator BT246_17210 ENOG4108S6Z Negative regulator of genetic competence BT246_17260 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BT246_17270 ENOG4107RB3 L-asparaginase BT246_17340 ENOG4105S2F BT246_17350 ENOG41065D1 BT246_17420 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BT246_17450 ENOG4105XXQ heptaprenyl diphosphate synthase component I BT246_17470 ENOG4105EAH synthase BT246_17480 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BT246_17490 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BT246_17520 ENOG41068YB TPR repeat-containing protein BT246_17550 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BT246_17560 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BT246_17630 ENOG4108JYZ YitT family BT246_17640 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BT246_17670 ENOG4105FJR Lmbe family BT246_17680 ENOG4105CPK Glycosyl transferase (Group 1 BT246_17720 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BT246_17750 ENOG4105DVT helicase BT246_17760 ENOG4105YAC BT246_17800 ENOG4105CSM endonuclease III BT246_17830 ENOG4105BZ4 penicillin-binding protein BT246_17920 ENOG4106F55 Protein of unknown function (DUF1273) BT246_17950 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BT246_17970 ENOG4105DVT helicase BT246_17980 ENOG4105CTD carboxy-peptidase BT246_18010 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BT246_18020 ENOG4105C2W permease BT246_18030 ENOG4105DHF Membrane BT246_18050 ENOG410890F Dynamin family BT246_18070 ENOG4108W0I acetyltransferase BT246_18090 ENOG4105KHC sulfurtransferase BT246_18190 ENOG4105HTX biosynthesis protein BT246_18250 ENOG4105CPK Glycosyl transferase (Group 1 BT246_18290 ENOG4108SZE gCN5-related N-acetyltransferase BT246_18330 ENOG41081VK Ribonuclease BT246_18460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BT246_18480 ENOG4107RWR Sodium hydrogen exchanger BT246_18490 ENOG4108Z5V transcriptional regulator, merr family BT246_18510 ENOG4105H67 Protein of unknown function (DUF421) BT246_18520 ENOG41080C8 DUF218 domain BT246_18620 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BT246_18640 ENOG4107R0U MotA TolQ exbB proton channel BT246_18650 ENOG4105ER2 Ompa motb domain protein BT246_18660 ENOG4107YTP response regulator receiver protein BT246_18670 ENOG4105CBS Chea signal transduction histidine kinase BT246_18680 ENOG4105DD5 Flagellar motor switch protein BT246_18710 ENOG4105BZU Histidine kinase BT246_18750 ENOG4105E1Q flagellar hook-associated protein BT246_18760 ENOG4105DTJ flagellar hook-associated protein BT246_18810 ENOG4107TPX flagellar hook-associated BT246_18840 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BT246_18850 ENOG4108ZC9 flagellar basal-body rod protein flgc BT246_18860 ENOG41075Z6 flagellar hook-basal body complex protein fliE BT246_18870 ENOG4107U2N Flagellar M-ring protein BT246_18880 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BT246_18940 ENOG4105BZE flagellar hook protein, FlgE BT246_18970 ENOG4107R88 Chemotaxis protein (CheV) BT246_18990 ENOG4105I03 Flagellin BT246_19000 ENOG4105I03 Flagellin BT246_19010 ENOG4105I03 Flagellin BT246_19020 ENOG4105I03 Flagellin BT246_19030 ENOG4105E4C Lytic transglycosylase catalytic BT246_19050 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BT246_19060 ENOG4105DD5 Flagellar motor switch protein BT246_19080 ENOG4105CN7 Flagellar biosynthetic protein FliP BT246_19090 ENOG4105VS8 Flagellar biosynthetic protein fliq BT246_19110 ENOG4105D00 flagellar biosynthetic protein flhB BT246_19120 ENOG4105D7B Flagellar biosynthesis protein flha BT246_19130 ENOG4105FZW flagellar biosynthesis regulator FlhF BT246_19140 ENOG4105KTQ flagellar basal-body rod protein BT246_19150 ENOG4105CPU Monooxygenase BT246_19230 ENOG4105KAC Antibiotic biosynthesis monooxygenase BT246_19280 ENOG4105DUM transcriptional regulator, lysR family BT246_19290 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BT246_19310 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BT246_19320 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BT246_19410 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BT246_19450 ENOG4105CAQ asparagine synthetase BT246_19490 ENOG4105PGM cation diffusion facilitator family transporter BT246_19500 ENOG4105PGM cation diffusion facilitator family transporter BT246_19520 ENOG4105DRR Transcriptional regulator, GntR family BT246_19530 ENOG4108UZ3 Transporter BT246_19550 ENOG4105CKI cobalamin synthesis protein BT246_19560 ENOG4108PJD permease BT246_19590 ENOG4105DFD Na H antiporter BT246_19600 ENOG4105VUF Transcriptional regulator BT246_19620 ENOG4105C9Q fumarate hydratase class II BT246_19650 ENOG4107QJQ Mate efflux family protein BT246_19660 ENOG4105EC3 peptidase S51, dipeptidase E BT246_19700 ENOG4107QIV Cytochrome c biogenesis protein BT246_19710 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BT246_19740 ENOG4107JM4 Tetratricopeptide repeat BT246_19760 ENOG4105BZC d-serine deaminase BT246_19770 ENOG4106BRA Membrane BT246_19840 ENOG4105CJ1 ABC, transporter BT246_19880 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BT246_19910 ENOG4108IJ0 Aspartate ammonia-lyase BT246_19920 ENOG4105C6K Malic enzyme BT246_20050 ENOG4105FVX BT246_20060 ENOG4105E09 nadh pyrophosphatase BT246_20100 ENOG4105CSR polyphosphate kinase 2 BT246_20110 ENOG4105U3E Transcriptional regulator BT246_20130 ENOG4105DXI Major Facilitator superfamily BT246_20160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BT246_20170 ENOG4105EU0 Major facilitator Superfamily BT246_20180 ENOG4105C6T cysteine synthase BT246_20230 ENOG4105C8J )-transporter BT246_20250 ENOG4105X5K response regulator receiver protein BT246_20260 ENOG4105H67 Protein of unknown function (DUF421) BT246_20310 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BT246_20320 ENOG4105CHR reductase BT246_20330 ENOG4105CM2 brancheD-chain amino acid aminotransferase BT246_20340 ENOG4105C7K acetolactate synthase BT246_20380 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BT246_20400 ENOG4105C7B Threonine dehydratase BT246_20470 ENOG4105C6X Major Facilitator BT246_20480 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BT246_20510 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BT246_20520 ENOG4105DY9 regulatoR BT246_20540 ENOG4105CYC Transferase BT246_20550 ENOG4105CYC Transferase BT246_20580 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BT246_20590 ENOG4105EQ0 Major Facilitator superfamily BT246_20600 ENOG4108IND Tetr family transcriptional regulator BT246_20620 ENOG41068WN BT246_20670 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BT246_20700 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BT246_20720 ENOG4105C0X amino acid BT246_20830 ENOG410849A acetyltransferase, (GNAT) family BT246_20870 ENOG4107RHR regulatoR BT246_20890 ENOG4105D9N nucleoside BT246_20900 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BT246_20960 ENOG4105DUM transcriptional regulator, lysR family BT246_21020 ENOG4107RAQ aminopeptidase BT246_21040 ENOG4107R16 Multicopper oxidase BT246_21120 ENOG4108T5E Copper resistance protein BT246_21130 ENOG4105KTB nuclear export factor GLE1 BT246_21140 ENOG4107RT3 EamA-like transporter family BT246_21150 ENOG4105GZI Transcriptional regulator BT246_21160 ENOG4108Z40 Transcriptional regulator BT246_21170 ENOG4107ZXU DSBA oxidoreductase BT246_21180 ENOG4108TVJ Nitroreductase BT246_21200 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BT246_21210 ENOG4106F5Q Membrane BT246_21220 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BT246_21240 ENOG4105CKI cobalamin synthesis protein BT246_21260 ENOG4105C0Z ABC transporter BT246_21270 ENOG4108IV0 ABC, transporter BT246_21280 ENOG4105C32 Amino acid ABC transporter (Permease) BT246_21300 ENOG4105EGI Transcriptional regulator BT246_21320 ENOG4105MDS 4-oxalocrotonate tautomerase BT246_21360 ENOG4105C4M (Ubiquinol oxidase) subunit I BT246_21370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BT246_21380 ENOG4108JJ9 ABC, transporter BT246_21390 ENOG4108JJ8 (ABC) transporter BT246_21410 ENOG4105K64 Glycosyl transferase, family 2 BT246_21430 ENOG4108UT6 Transferase hexapeptide repeat containing protein BT246_21520 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BT246_21550 ENOG4105BZ1 (ABC) transporter BT246_21560 ENOG4105EFI regulatoR BT246_21570 ENOG4105BZU Histidine kinase BT246_21610 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BT246_21620 ENOG4108ZJ4 polysaccharide deacetylase BT246_21680 ENOG4105D6E homoserine dehydrogenase BT246_21700 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BT246_21730 ENOG4108KGH TRANSCRIPTIONal BT246_21750 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BT246_21760 ENOG4105BZU Histidine kinase BT246_21770 ENOG4107VMI polysaccharide deacetylase BT246_21790 ENOG4105KT7 mgtC SapB transporter BT246_21800 ENOG4105VRR gCN5-related N-acetyltransferase BT246_21820 ENOG4105DUU IucA IucC family protein BT246_21830 ENOG4105CEY Amp-dependent synthetase and ligase BT246_21860 ENOG4108WBH protein TIM barrel BT246_21870 ENOG4105YWU small acid-soluble spore protein BT246_21890 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BT246_21900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BT246_22000 ENOG4105KRN Transcriptional regulator, abrb family BT246_22020 ENOG4105YVS arsR family transcriptional regulator BT246_22030 ENOG4105CPC Aldo Keto reductase BT246_22040 ENOG4107XZQ multidrug resistance protein BT246_22090 ENOG4105C8Q Methyl-accepting chemotaxis BT246_22120 ENOG4108K88 Membrane BT246_22130 ENOG4108WPJ Ferritin-like domain BT246_22240 ENOG4108TFU terminase (Small subunit) BT246_22260 ENOG4105MZU cell filamentation protein BT246_22300 ENOG4105DEN Luciferase family BT246_22330 ENOG4105VMI -acetyltransferase BT246_22340 ENOG4107QM2 Aldo Keto reductase BT246_22350 ENOG4105CKI cobalamin synthesis protein BT246_22370 ENOG4105DSE periplasmic solute binding protein BT246_22390 ENOG4105K4T epimerase BT246_22410 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BT246_22500 ENOG4107T5V SNARE associated Golgi BT246_22530 ENOG4108PJD permease BT246_22550 ENOG4108S4H thioesterase Superfamily protein BT246_22560 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BT246_22600 ENOG4105SXS Protein of unknown function (DUF456) BT246_22610 ENOG4105C37 (CBS) domain BT246_22670 ENOG4108Z7R Chaperone CsaA BT246_22710 ENOG4108ZRV stage ii sporulation protein p BT246_22730 ENOG4108VXD carboxy-peptidase BT246_22790 ENOG4108ZRV stage ii sporulation protein p BT246_22810 ENOG4108X4Q Hydrolase BT246_22820 ENOG41082F9 transcriptional regulator BT246_22830 ENOG4105D94 Major Facilitator Superfamily BT246_22850 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BT246_22860 ENOG4107RBS Methyltransferase BT246_22890 ENOG41087PP glycosyltransferase MGT family BT246_22900 ENOG4108JYZ YitT family BT246_22910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BT246_22970 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BT246_23060 ENOG4105KBJ sporulation protein ytfj BT246_23110 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BT246_23150 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BT246_23160 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BT246_23180 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BT246_23190 ENOG4105EMN RNA polymerase sigma factor BT246_23220 ENOG4105CNW domain protein BT246_23240 ENOG4108V06 Glutathione peroxidase BT246_23270 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BT246_23330 ENOG4108IUE nitrate reductase beta subunit BT246_23340 ENOG4105R3A Nitrate reductase BT246_23360 ENOG4107V6Q Cyclic nucleotide-binding domain BT246_23370 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BT246_23380 ENOG4105D06 uba thif-type nad fad binding protein BT246_23390 ENOG4105CVM Molybdenum cofactor synthesis domain protein BT246_23400 ENOG4108ZAF Molybdopterin BT246_23450 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BT246_23460 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BT246_23470 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BT246_23480 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BT246_23490 ENOG4108IFG nitrite reductase, (NAD(P)H) BT246_23500 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BT246_23570 ENOG4105MCT stage V sporulation protein S BT246_23590 ENOG4108IBT Inherit from COG: transposase BT246_23630 ENOG4105C5H ABC transporter BT246_23660 ENOG4108UUM single-stranded DNA-binding protein BT246_23710 ENOG4107YX5 Pfam:DUF548 BT246_23730 ENOG4105C75 arginyL-tRNA synthetase BT246_23790 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BT246_23840 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BT246_23860 ENOG4105C5S asparaginyl-tRNA synthetase BT246_23880 ENOG4105C8J )-transporter BT246_23920 ENOG4107XGZ Hydrolase BT246_23930 ENOG4105CY2 Citrate transporter BT246_23970 ENOG4105KD7 acetyltransferase BT246_23990 ENOG4105VMP Transcriptional regulator BT246_24000 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BT246_24050 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BT246_24100 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BT246_24130 ENOG4107RVG penicillin-binding protein BT246_24150 ENOG4105E9Q Acyl-transferase BT246_24160 ENOG4108UT2 hemolysin iii BT246_24180 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BT246_24200 ENOG4108RCR degv family BT246_24220 ENOG4108KF3 Electron transport protein SCO1 SenC BT246_24230 ENOG4107Y70 Heat shock protein BT246_24240 ENOG4105CAQ asparagine synthetase BT246_24270 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BT246_24280 ENOG4108MES Periplasmic binding protein BT246_24300 ENOG4105F0I Aminotransferase BT246_24360 ENOG4105D8X mechanosensitive ion channel BT246_24380 ENOG4105BZU Histidine kinase BT246_24390 ENOG4105WH1 Two component transcriptional regulator luxr family BT246_24410 ENOG4106KNT transcriptional regulator BT246_24420 ENOG4107ZY0 Phenazine biosynthesis-like protein BT246_24470 ENOG4105CMG Carbohydrate kinase BT246_24480 ENOG4105C6Z Gluconate BT246_24500 ENOG4108YV3 Protein of unknown function (DUF2711) BT246_24560 ENOG4108IJ8 ABC transporter BT246_24570 ENOG4105E90 ABC transporter BT246_24640 ENOG4105C37 (CBS) domain BT246_24690 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BT246_24720 ENOG4107S4Y M20 DapE family protein YgeY BT246_24730 ENOG4108TSC N-acetyltransferase BT246_24740 ENOG4108JUB Transcriptional regulator BT246_24750 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BT246_24840 ENOG410841Q phosphoesterase PA-phosphatase related protein BT246_24860 ENOG4105SZ6 Thioredoxin BT246_24870 ENOG4105KNA -acetyltransferase BT246_24960 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BT246_25060 ENOG4105BZ4 penicillin-binding protein BT246_25080 ENOG4105CZM Major Facilitator BT246_25090 ENOG4105W8X HesB YadR YfhF-family protein BT246_25110 ENOG4105DXD 2-methylcitrate dehydratase BT246_25120 ENOG4105CR4 methylisocitrate lyase BT246_25130 ENOG4105C1G acyl-Coa dehydrogenase BT246_25140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BT246_25160 ENOG4105N14 lysine exporter protein LysE YggA BT246_25170 ENOG4105E39 Enoyl-CoA hydratase BT246_25200 ENOG4107RFY SbcCD D subunit BT246_25210 ENOG4105EYH Exonuclease BT246_25250 ENOG4105FCD Major Facilitator BT246_25260 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BT246_25270 ENOG4105E4F Isochorismate synthase BT246_25280 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BT246_25290 ENOG4105WQI isochorismatase BT246_25300 ENOG4105CEY Amp-dependent synthetase and ligase BT246_25310 ENOG4105WQT MbtH domain protein BT246_25320 ENOG4105C0R drug resistance transporter emrb qaca subfamily BT246_25350 ENOG4105K70 DNA-binding protein BT246_25390 ENOG4105BZG amino acid carrier protein BT246_25430 ENOG4105FE9 pseudouridine synthase BT246_25460 ENOG4105C22 threonyL-tRNA synthetase BT246_25470 ENOG4105C19 ABC transporter BT246_25570 ENOG41081I9 integral membrane protein BT246_25590 ENOG4108Y4K DNA-binding transcriptional activator BT246_25620 ENOG4107MII Sugar-specific transcriptional regulator TrmB BT246_25640 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BT246_25660 ENOG4105EYF MMPL domain protein BT246_25710 ENOG4105WCN acetyltransferase BT246_25760 ENOG4105C1Q protoporphyrinogen oxidase BT246_25780 ENOG41068WN BT246_25840 ENOG4107V2S Transcriptional regulator BT246_25850 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BT246_25900 ENOG4105DND Transcriptional regulator BT246_25910 ENOG4108RPX mosc domain containing protein BT246_25940 ENOG4105BZ1 (ABC) transporter BT246_25950 ENOG4105BZ1 (ABC) transporter BT246_25990 ENOG4108VP3 Lysine exporter protein (LysE YggA) BT246_26000 ENOG4108JCI Transcriptional regulator BT246_26100 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BT246_26110 ENOG4108KPJ rna polymerase sigma factor BT246_26160 ENOG4105F32 YngK protein BT246_26200 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BT246_26210 ENOG4105RD7 BadF BadG BcrA BcrD BT246_26220 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BT246_26240 ENOG4105C7B Threonine dehydratase BT246_26250 ENOG4108INS Transcriptional regulator BT246_26290 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BT246_26300 ENOG4105C1J atp-dependent rna helicase BT246_26350 ENOG4105KRN Transcriptional regulator, abrb family BT246_26530 ENOG41088CC tellurite resistance protein tehB BT246_26550 ENOG4108I0C methyltransferase BT246_26560 ENOG4107RA9 decarboxylase BT246_26570 ENOG4105K56 Transcriptional regulator BT246_26580 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BT246_26630 ENOG4105CIN aminoacyl-histidine dipeptidase BT246_26720 ENOG4105KRN Transcriptional regulator, abrb family BT246_26740 ENOG4105EJ9 Membrane BT246_26750 ENOG4105EQK -acetyltransferase BT246_26890 ENOG4105BZU Histidine kinase BT246_26910 ENOG4107S9D Alpha beta hydrolase BT246_27030 ENOG4107SCK Monooxygenase BT246_27060 ENOG4105DU0 nucleoside hydrolase BT246_27110 ENOG4108VJ1 Transcriptional regulator (CarD family BT246_27160 ENOG410829K Lysine exporter protein (Lyse ygga) BT246_27180 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BT246_27190 ENOG4105FQP Beta-lactamase BT246_27200 ENOG4107RVG penicillin-binding protein BT246_27230 ENOG4107RF6 penicillin-binding protein BT246_27240 ENOG4107RF6 penicillin-binding protein BT246_27260 ENOG4105DIN metallophosphoesterase BT246_27280 ENOG4105CJ1 ABC, transporter BT246_27310 ENOG4107Z3H Transcriptional regulator, TetR family BT246_27340 ENOG4105C1G acyl-Coa dehydrogenase BT246_27350 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BT246_27360 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BT246_27370 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BT246_27380 ENOG4105E39 Enoyl-CoA hydratase BT246_27390 ENOG4107QX3 carboxylase BT246_27400 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BT246_27460 ENOG4105DZ1 carboxypeptidase BT246_27490 ENOG4105T9C HD domain BT246_27550 ENOG41075H3 AraC family transcriptional regulator BT246_27620 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BT246_27650 ENOG4107Y80 Major Facilitator superfamily BT246_27660 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BT246_27670 ENOG4105KVH Transcriptional regulator BT246_27730 ENOG4105CUV Homoserine Kinase BT246_27790 ENOG4105EFA 4-hydroxyphenylacetate BT246_27810 ENOG4105CPQ Dehydrogenase BT246_27850 ENOG410900G Protein of unknown function (DUF421) BT246_27870 ENOG4108V4B ThiJ pfpI BT246_27890 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BT246_27910 ENOG4105DK7 lysyl-tRNA synthetase BT246_28090 ENOG4105D6E homoserine dehydrogenase BT246_28110 ENOG4105CPF Cell wall formation (By similarity) BT246_28120 ENOG4105ETU transcriptional activator (TenA BT246_28330 ENOG410667J hydrolase BT246_28340 ENOG4105BZU Histidine kinase BT246_28350 ENOG4107RF6 penicillin-binding protein BT246_28360 ENOG4107RF6 penicillin-binding protein BT246_28420 ENOG4108JJB ABC transporter BT246_28450 ENOG4108HGU Histidine kinase BT246_28630 ENOG4107WD8 ABC transporter, permease BT246_28720 ENOG4105BZU Histidine kinase BT246_28730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_28740 ENOG4105PAD Hydrolase BT246_28790 ENOG4107VFR oxidoreductase BT246_28870 ENOG4105PKS Excinuclease abc c subunit domain protein BT246_28940 ENOG4105KWG Pfam:DUF1696 BT246_28950 ENOG4108NRW Phospholipase, patatin family BT246_29000 ENOG4108XI2 Domain of unknown function (DUF1963) BT246_29080 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BT246_29090 ENOG4105E09 nadh pyrophosphatase BT246_29110 ENOG4105FCD Major Facilitator BT246_29220 ENOG4107Y9U Membrane BT246_29280 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BT246_29330 ENOG4107Y80 Major Facilitator superfamily BT246_29470 ENOG4105CJN penicillin-binding protein BT246_29480 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BT246_29490 ENOG4105CB2 alcohol dehydrogenase BT246_29580 ENOG4108IUM Glycogen debranching enzyme BT246_29660 ENOG4105CGH 5'-nucleotidase BT246_29690 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BT246_29710 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BT246_29720 ENOG4105FDR Membrane BT246_29740 ENOG4105CIS alcohol dehydrogenase BT246_29750 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BT246_29840 ENOG4105MSI germination protein ypeb BT246_29910 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) BT246_29920 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BT246_29930 ENOG4107Z3H Transcriptional regulator, TetR family BT246_30020 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BT246_30050 ENOG4105E98 transcriptional regulator DeoR family BT246_30080 ENOG41062ES Transcriptional regulator BT246_30120 ENOG4107QKR Dehydrogenase BT246_30140 ENOG4107RUY (E1 component), alpha subunit BT246_30160 ENOG4105E1F short-chain dehydrogenase reductase BT246_30170 ENOG4105RHY Pfam:UPF0157 BT246_30250 ENOG4107SQ8 Glycine betaine BT246_30260 ENOG4108IJ7 Glycine betaine BT246_30280 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BT246_30310 ENOG4105E66 phosphoriboisomerase A BT246_30320 ENOG41082BV acetyltransferase BT246_30330 ENOG4108M1A Chitin-binding protein BT246_30380 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BT246_30390 ENOG4105MSB protein, conserved in bacteria BT246_30430 ENOG4108Z7F N-acetyltransferase BT246_30490 ENOG4105EEM helicase BT246_30500 ENOG4105EEM helicase BT246_30540 ENOG4105C9U ATP-dependent DNA helicase RecQ BT246_30650 ENOG4108M1A Chitin-binding protein BT246_30690 ENOG4105BZG amino acid carrier protein BT246_30700 ENOG4105C26 Dehydrogenase BT246_30710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BT246_30720 ENOG4105CTU Proline racemase BT246_30730 ENOG4105CTU Proline racemase BT246_30740 ENOG4105CTU Proline racemase BT246_30750 ENOG41080HI glycine oxidase BT246_30770 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein BT246_30850 ENOG4107T5V SNARE associated Golgi BT246_30870 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BT246_30880 ENOG4108428 Inherit from COG: -acetyltransferase BT246_30910 ENOG4105DTQ mandelate racemase muconate lactonizing BT246_30940 ENOG4107SET aldo keto reductase BT246_31020 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BT246_31030 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BT246_31040 ENOG4105BZU Histidine kinase BT246_31050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_31090 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 BT246_31130 ENOG4105DPN Oligoendopeptidase f BT246_31140 ENOG4105EPR degv family BT246_31250 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BT246_31260 ENOG4106K7D Major facilitator family transporter BT246_31310 ENOG4107BMA Transglycosylase associated protein BT246_31340 ENOG41089UC methyltransferase, type 11 BT246_31420 ENOG4105CHM Aminotransferase BT246_31450 ENOG4108ZMI UPF0477 protein BT246_31550 ENOG4105C02 permease BT246_31610 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BT246_31620 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BT246_31630 ENOG4105D7T ABC transporter BT246_31750 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BT246_31820 ENOG4107VC0 DNA alkylation repair enzyme BT246_31830 ENOG4105C6T cysteine synthase BT246_31840 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BT246_31870 ENOG4107VMI polysaccharide deacetylase BT246_31880 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BT246_31910 ENOG4106ETB IIa component BT246_31930 ENOG4108ZCF integral membrane protein BT246_31940 ENOG4105E0M Sulfatase BT246_31950 ENOG4105C5H ABC transporter BT246_31960 ENOG4105EYF MMPL domain protein BT246_31970 ENOG4105EYF MMPL domain protein BT246_31980 ENOG41082JN Transcriptional regulator BT246_32030 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BT246_32050 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BT246_32170 ENOG41069ER domain protein BT246_32190 ENOG4105DNP FAD linked oxidase domain protein BT246_32240 ENOG4105D4B ABC, transporter BT246_32250 ENOG4105F5R ABC transporter BT246_32270 ENOG4105C2J ABC transporter BT246_32290 ENOG4105DKT Transcriptional regulator BT246_32300 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BT246_32340 ENOG41061GT Aldolase BT246_32380 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BT246_32470 ENOG4105II7 pyrroline-5-carboxylate reductase BT246_32500 ENOG4107258 Transcriptional regulator BT246_32540 ENOG4105ECK Fatty Acid Desaturase BT246_32560 ENOG4107RBI VanW family BT246_32580 ENOG4105G6Z alkaline phosphatase BT246_32600 ENOG4105VMP Transcriptional regulator BT246_32650 ENOG41068WN BT246_32710 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BT246_32750 ENOG4105C8Y Acetylornithine aminotransferase BT246_32760 ENOG4105C8Y Acetylornithine aminotransferase BT246_32870 ENOG4108TVJ Nitroreductase BT246_32880 ENOG4105FS7 Transcriptional regulator BT246_32930 ENOG4105WEC Molybdate metabolism regulator BT246_32940 ENOG4105CMR udp-glucose 4-epimerase BT246_32950 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BT246_33000 ENOG4108DMH HTH_ARAC BT246_33010 ENOG4108XET gCN5-related N-acetyltransferase BT246_33040 ENOG4108PCN EamA-like transporter family BT246_33140 ENOG410635A Membrane BT246_33150 ENOG4108428 Inherit from COG: -acetyltransferase BT246_33170 ENOG4108IQI permease BT246_33200 ENOG4105F1N DNA alkylation repair BT246_33220 ENOG4105BZU Histidine kinase BT246_33230 ENOG4105BZU Histidine kinase BT246_33240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_33280 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BT246_33350 ENOG4107RF6 penicillin-binding protein BT246_33370 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BT246_33380 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BT246_33410 ENOG4105E7W lamb ycsf family protein BT246_33430 ENOG4105P4J Allophanate hydrolase, subunit 1 BT246_33440 ENOG4107258 Transcriptional regulator BT246_33460 ENOG4106N3A copper homeostasis protein cutc BT246_33470 ENOG4108ZHR arsR family transcriptional regulator BT246_33490 ENOG4105FDT acyl-CoA dehydrogenase BT246_33530 ENOG4105DWD nucleoside recognition domain protein BT246_33630 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BT246_33780 ENOG4105E2A Dehydrogenase BT246_33800 ENOG4105CN5 Metallo-Beta-Lactamase BT246_33820 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BT246_33860 ENOG4105CGH 5'-nucleotidase BT246_33880 ENOG4105CHJ isochorismatase hydrolase BT246_33930 ENOG41090MY MarR family Transcriptional regulator BT246_34050 ENOG4105E1K spore germination protein BT246_34080 ENOG4108606 TspO/MBR family BT246_34090 ENOG4105CVP deoxyribo-dipyrimidine photolyase BT246_34140 ENOG4108TWJ NADH dehydrogenase subunit 5 BT246_34170 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BT246_34180 ENOG4107VMI polysaccharide deacetylase BT246_34190 ENOG4105KY5 gCN5-related N-acetyltransferase BT246_34200 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BT246_34220 ENOG4105D6J arsenicaL-resistance protein BT246_34230 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BT246_34240 ENOG41085FC arsR family transcriptional regulator BT246_34280 ENOG4105NAE bifunctional deaminase-reductase domain protein BT246_34320 ENOG4107P5I polyketide synthase BT246_34330 ENOG4108IG5 Transcriptional regulator BT246_34380 ENOG4105EQ0 Major Facilitator superfamily BT246_34390 ENOG4108JGH Tetr family transcriptional regulator BT246_34410 ENOG4105XRQ Xanthine dehydrogenase accessory factor BT246_34440 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BT246_34480 ENOG4105CHR reductase BT246_34490 ENOG4108YXU transcriptional regulator AsnC family BT246_34590 ENOG4105C44 Serine transporter BT246_34610 ENOG4105DUM transcriptional regulator, lysR family BT246_34620 ENOG4105DWP Membrane BT246_34630 ENOG4105N0V mono-oxygenase ydhR BT246_34730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_34740 ENOG41062D9 Histidine kinase BT246_34820 ENOG4105C19 ABC transporter BT246_34880 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BT246_34890 ENOG4105C0R drug resistance transporter emrb qaca subfamily BT246_34930 ENOG4105K6H D-cysteine desulfhydrase BT246_34950 ENOG41066YJ Beta-lactamase BT246_34960 ENOG4105JQZ Methyltransferase BT246_35000 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BT246_35040 ENOG4105BZU Histidine kinase BT246_35090 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BT246_35120 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BT246_35160 ENOG4108JQ1 Dehydrogenase BT246_35170 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BT246_35200 ENOG41082W1 Cupin 2, conserved barrel domain protein BT246_35210 ENOG410874W AraC family transcriptional regulator BT246_35250 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BT246_35290 ENOG4108VXD carboxy-peptidase BT246_35300 ENOG4105PNM synthesis protein BT246_35320 ENOG4108ISG Major Facilitator BT246_35350 ENOG4107MII Sugar-specific transcriptional regulator TrmB BT246_35360 ENOG4105CZM Major Facilitator BT246_35390 ENOG4105DA5 (ABC) transporter BT246_35400 ENOG41069JR BT246_35430 ENOG4105CRW Short chain fatty acid transporter BT246_35450 ENOG4105DYS nad(p)h dehydrogenase (quinone) BT246_35580 ENOG4108K8S endonuclease I BT246_35660 ENOG4108Z66 YbaK ebsC protein BT246_35700 ENOG4105KVH Transcriptional regulator BT246_35710 ENOG4108RCM Nitroreductase BT246_35780 ENOG4108PSK reductase BT246_35930 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BT246_35940 ENOG4105DKQ ROK family BT246_35960 ENOG4108UW5 maltose o-acetyltransferase BT246_35970 ENOG4105C31 Tryptophanyl-tRNA synthetase BT246_36110 ENOG4105C37 (CBS) domain BT246_36150 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BT246_36160 ENOG4105FAW cDP-glucose 4,6-dehydratase BT246_36230 ENOG4105DDN Pentapeptide repeat-containing protein BT246_36240 ENOG4105XDF Protein of unknown function (DUF1272) BT246_36250 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BT246_36260 ENOG4105CMG Carbohydrate kinase BT246_36270 ENOG4105C6Z Gluconate BT246_36300 ENOG4105CV1 Transketolase (EC 2.2.1.1) BT246_36310 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BT246_36320 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BT246_36330 ENOG4105CIS alcohol dehydrogenase BT246_36340 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BT246_36360 ENOG4105PDP Short chain dehydrogenase BT246_36400 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BT246_36490 ENOG4105C8Q Methyl-accepting chemotaxis BT246_36500 ENOG4108UX3 '-nucleotidase BT246_36510 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BT246_36520 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BT246_36530 ENOG4105KVH Transcriptional regulator BT246_36620 ENOG4105CV8 reductase BT246_36630 ENOG4105F27 Major Facilitator BT246_36680 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BT246_36690 ENOG4105CHH sulfate transporter BT246_36720 ENOG4105C44 Serine transporter BT246_36800 ENOG4105KVH Transcriptional regulator BT246_36810 ENOG4108TZY GntR Family Transcriptional Regulator BT246_36820 ENOG4105D9R oxidoreductase BT246_36830 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BT246_36840 ENOG4105KVH Transcriptional regulator BT246_36850 ENOG4105KVH Transcriptional regulator BT246_36960 ENOG4105JAB phenazine biosynthesis protein, phzf family BT246_36990 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BT246_37000 ENOG4105KVH Transcriptional regulator BT246_37030 ENOG4108ZJ4 polysaccharide deacetylase BT246_37190 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BT246_37220 ENOG4107YXZ hydrolase, family 25 BT246_37300 ENOG4105H3G oxidoreductase BT246_37310 ENOG4105H3G oxidoreductase BT246_37440 ENOG4108TN2 lmbE family BT246_37460 ENOG4107R3E Citrate transporter BT246_37500 ENOG4108MES Periplasmic binding protein BT246_37510 ENOG4105EHG Permease protein BT246_37520 ENOG4105DQ5 transport system permease protein BT246_37530 ENOG4105NX3 Membrane BT246_37570 ENOG4107CUJ Protein of unknown function (DUF2690) BT246_37600 ENOG4107V2S Transcriptional regulator BT246_37640 ENOG4105C98 muts2 protein BT246_37660 ENOG4105E5K Alpha-amylase BT246_37670 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BT246_37680 ENOG4105DPN Oligoendopeptidase f BT246_37730 ENOG4105FFC UPF0187 protein BT246_37760 ENOG4108A04 Beta-lactamase BT246_37810 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BT246_37830 ENOG41082BM Transcriptional regulator, arsr family BT246_37840 ENOG4105CIS alcohol dehydrogenase BT246_37850 ENOG4105CNG UPF0061 protein BT246_37900 ENOG4105RHY Pfam:UPF0157 BT246_37920 ENOG4105CQB FAD linked oxidase domain protein BT246_37950 ENOG4107TPS domain protein BT246_38000 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BT246_38080 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BT246_38100 ENOG4108M1A Chitin-binding protein BT246_38140 ENOG4105E1K spore germination protein BT246_38180 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BT246_38200 ENOG4108IAJ Nad-dependent epimerase dehydratase BT246_38210 ENOG4105FAW cDP-glucose 4,6-dehydratase BT246_38390 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BT246_38400 ENOG4105XSJ toxin secretion phage lysis holin BT246_38570 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BT246_38590 ENOG4105CAR Terminase, large subunit BT246_38640 ENOG4106E8G BT246_38800 ENOG4106050 phage regulatory protein, rha family BT246_38850 ENOG4108IMY Transcriptional regulator BT246_38910 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BT246_38930 ENOG4108VXD carboxy-peptidase BT246_38940 ENOG4107DUR UPF0457 protein BT246_38960 ENOG4105EKQ RNA-directed DNA polymerase BT246_38980 ENOG4105EKQ RNA-directed DNA polymerase BT246_39010 ENOG4105EKQ RNA-directed DNA polymerase BT246_39050 ENOG4105BZU Histidine kinase BT246_39070 ENOG4105KT7 mgtC SapB transporter BT246_39090 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BT246_39110 ENOG41073R8 VanW family BT246_39130 ENOG4108R1P BT246_39180 ENOG410907Z n-acetylmuramoyl-l-alanine amidase BT246_39480 ENOG4105DVF Cytosine-specific methyltransferase BT246_39530 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BT246_39550 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BT246_39610 ENOG4105C2M dna polymerase I BT246_39800 ENOG4105VTR Integrase BT246_39810 ENOG4108R1P BT246_39850 ENOG4105VEQ Cold shock protein BT246_39940 ENOG410904N short-chain dehydrogenase reductase BT246_39960 ENOG4106IQC argininosuccinate lyase BT246_39990 ENOG4108IA2 Sodium pantothenate symporter BT246_40010 ENOG4108IA2 Sodium pantothenate symporter BT246_40030 ENOG4105C26 Dehydrogenase BT246_40040 ENOG4105CHR reductase BT246_40060 ENOG4105EWU Squalene--hopene cyclase BT246_40090 ENOG4105FR1 rard protein BT246_40100 ENOG410696E Membrane BT246_40130 ENOG4105D1F ATP-binding protein BT246_40150 ENOG4108ZAF Molybdopterin BT246_40160 ENOG4105CVM Molybdenum cofactor synthesis domain protein BT246_40170 ENOG4105D06 uba thif-type nad fad binding protein BT246_40180 ENOG4105TMB Formate nitrite transporter BT246_40200 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BT246_40210 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BT246_40230 ENOG4108JB9 formate dehydrogenase BT246_40320 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BT246_40450 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BT246_40480 ENOG4105CAR Terminase, large subunit BT246_40640 ENOG4105YQ0 BT246_40680 ENOG4106050 phage regulatory protein, rha family BT246_40710 ENOG4108IMY Transcriptional regulator BT246_40750 ENOG4108JB9 formate dehydrogenase BT246_40760 ENOG4105E1K spore germination protein BT246_40790 ENOG4105CUB amino acid BT246_40900 ENOG4108KGH TRANSCRIPTIONal BT246_40920 ENOG4105EMN RNA polymerase sigma factor BT246_40940 ENOG4105CIG ABC transporter BT246_40980 ENOG4105D9R oxidoreductase BT246_41000 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BT246_41010 ENOG4105K4P CoA-binding domain protein BT246_41020 ENOG4105C0H protease BT246_41030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_41050 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BT246_41060 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BT246_41070 ENOG4105W8X HesB YadR YfhF-family protein BT246_41120 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BT246_41130 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BT246_41150 ENOG4108JJA ABC, transporter BT246_41160 ENOG4108I0Z Aconitate hydratase BT246_41220 ENOG4105E5W Transporter BT246_41240 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BT246_41280 ENOG4107F3J Amp-dependent synthetase and ligase BT246_41290 ENOG4107ZYJ bioY protein BT246_41300 ENOG4105CEY Amp-dependent synthetase and ligase BT246_41320 ENOG4105BZU Histidine kinase BT246_41360 ENOG4105C19 ABC transporter BT246_41400 ENOG4105CJ1 ABC, transporter BT246_41620 ENOG4107AYK membrAne BT246_41640 ENOG4105BZU Histidine kinase BT246_41650 ENOG4105FBA Phospholipase Carboxylesterase BT246_41660 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BT246_41670 ENOG4105CK7 Sodium proline symporter BT246_41680 ENOG4105CBC glutamate synthase BT246_41690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BT246_41700 ENOG4108VJ1 Transcriptional regulator (CarD family BT246_41710 ENOG4108903 Formimidoylglutamase BT246_41760 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BT246_41820 ENOG4107QIV Cytochrome c biogenesis protein BT246_41850 ENOG4105CH2 amidohydrolase BT246_41870 ENOG4105CJ1 ABC, transporter BT246_41910 ENOG4107RSM transcriptional regulator BT246_41920 ENOG4105VAW lrga family BT246_41930 ENOG41067MG lrgb family BT246_42020 ENOG4105BZ1 (ABC) transporter BT246_42030 ENOG4105BZ1 (ABC) transporter BT246_42100 ENOG4108HW3 (ABC) transporter BT246_42110 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BT246_42130 ENOG4105CGH 5'-nucleotidase BT246_42150 ENOG4108SVB resolvase BT246_42190 ENOG4105K7K Transcriptional regulator BT246_42200 ENOG4105C5F glutamine synthetase BT246_42210 ENOG4105KV4 Transcriptional regulator BT246_42220 ENOG4105CXI aluminum resistance protein BT246_42230 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BT246_42240 ENOG4105EN6 Membrane BT246_42260 ENOG4106F1P AAA ATPase, central domain protein BT246_42320 ENOG41069ER domain protein BT246_42330 ENOG4105DM4 PTS System BT246_42340 ENOG4105DE4 1-phosphofructokinase BT246_42350 ENOG4105E98 transcriptional regulator DeoR family BT246_42360 ENOG4107QW4 alcohol dehydrogenase BT246_42370 ENOG4108SJC Membrane BT246_42400 ENOG4105C85 amino acid BT246_42430 ENOG4105TMB Formate nitrite transporter BT246_42440 ENOG4105K70 DNA-binding protein BT246_42460 ENOG4105C59 p-type ATPase BT246_42470 ENOG410681U heavy metal transport detoxification protein BT246_42480 ENOG4105VPX protein, conserved in bacteria BT246_42500 ENOG4105NIV Esterase BT246_42510 ENOG4105E0A ABC, transporter BT246_42550 ENOG4105CGK Exodeoxyribonuclease III BT246_42570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BT246_42580 ENOG4105D03 DNA-3-methyladenine glycosylase II BT246_42640 ENOG4105BZU Histidine kinase BT246_42710 ENOG41067MG lrgb family BT246_42750 ENOG4108S3Y transcriptional regulator BT246_42760 ENOG4105CS2 ec 3.2.1.21 BT246_42770 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C BT246_42800 ENOG4105F0V Cell wall hydrolase BT246_42820 ENOG4105E0M Sulfatase BT246_42830 ENOG410890F Dynamin family BT246_42900 ENOG4105DQU oxidoreductase, subunit beta BT246_42910 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BT246_42920 ENOG4108IGT Dipeptidase BT246_42930 ENOG4105MCT stage V sporulation protein S BT246_42940 ENOG4105D48 metallophosphoesterase BT246_42980 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BT246_43010 ENOG4105XZV Protein of unknown function (DUF3243) BT246_43020 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BT246_43060 ENOG4105UIB (ABC) transporter BT246_43070 ENOG4108JQ9 ABC transporter BT246_43080 ENOG4105DIH basic membrane BT246_43090 ENOG4105FDP GntR family transcriptional regulator BT246_43110 ENOG4105CNU cell division protein FtsK BT246_43130 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BT246_43150 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BT246_43180 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BT246_43190 ENOG4108S0H Dipicolinic acid synthetase, b subunit BT246_43200 ENOG4105E35 Dipicolinate synthase subunit A BT246_43220 ENOG4105C1V Peptidase, M16 BT246_43270 ENOG4105DTN riboflavin biosynthesis protein ribF BT246_43300 ENOG4105W7A Protein of unknown function (DUF503) BT246_43320 ENOG4105VHM ribosomal protein BT246_43330 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BT246_43340 ENOG4105CHV Transcription elongation factor NusA BT246_43360 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BT246_43380 ENOG4105DZP Membrane-associated zinc metalloprotease BT246_43390 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BT246_43400 ENOG4105KNE Phosphatidate cytidylyltransferase BT246_43410 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BT246_43430 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BT246_43490 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BT246_43500 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BT246_43520 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BT246_43530 ENOG4105C79 DNA protecting protein DprA BT246_43540 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BT246_43570 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BT246_43620 ENOG4105VB6 UPF0109 protein BT246_43660 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BT246_43670 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BT246_43700 ENOG4105CHR reductase BT246_43710 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BT246_43740 ENOG4105CB5 ATP-dependent DNA helicase recG BT246_43750 ENOG4105DP4 dak2 domain fusion protein ylov BT246_43760 ENOG4108ZAA Alkaline-shock protein BT246_43780 ENOG4105FJ0 thiamine BT246_43790 ENOG4105DJV ribulose-phosphate 3-epimerase BT246_43800 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BT246_43810 ENOG4105D9P serine threonine protein kinase BT246_43820 ENOG4108ZF3 Phosphatase BT246_43840 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BT246_43870 ENOG4105C25 Primosomal protein n' BT246_43880 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BT246_43920 ENOG4105DSJ YicC domain protein BT246_43940 ENOG4105F23 Fibronectin-binding protein BT246_43970 ENOG4105DC7 peptidase M24 BT246_44070 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BT246_44140 ENOG4105C34 Pseudouridine synthase BT246_44170 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BT246_44200 ENOG4105DBK s4 domain protein BT246_44210 ENOG41067XK integral membrane protein BT246_44230 ENOG4105DFA alanine racemase domain protein BT246_44240 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BT246_44250 ENOG4105WR5 sporulation protein, YlmC YmxH family BT246_44270 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_44290 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BT246_44300 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BT246_44320 ENOG4105D4A Cell wall formation (By similarity) BT246_44330 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BT246_44340 ENOG4105CNI cell division protein FtsW BT246_44370 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BT246_44380 ENOG4105CJN penicillin-binding protein BT246_44390 ENOG4105CJN penicillin-binding protein BT246_44420 ENOG41074B2 UPF0747 protein BT246_44470 ENOG4105KNH Nucleic acid-binding protein BT246_44490 ENOG41063PX domain protein BT246_44500 ENOG4105D78 K07001 NTE family protein BT246_44510 ENOG4105H20 Sporulation integral membrane protein YlbJ BT246_44530 ENOG4106H78 methyltransferase BT246_44580 ENOG4107TB6 phosphoglycerate mutase BT246_44610 ENOG4106UY4 Inherit from COG: Scp-like extracellular BT246_44710 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BT246_44720 ENOG4105CNI cell division protein FtsW BT246_44750 ENOG4108IAB Phoh family BT246_44790 ENOG4105QA2 BT246_44800 ENOG4105CI3 gtp-binding protein typa BT246_44820 ENOG4105ECY inositol monophosphatase BT246_44860 ENOG4105CXN decarboxylase BT246_44960 ENOG4105CPP Dehydrogenase, E1 component BT246_44990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BT246_45000 ENOG4108X4Q Hydrolase BT246_45020 ENOG4105CN5 Metallo-Beta-Lactamase BT246_45030 ENOG4107ZYR domain protein BT246_45100 ENOG4108XRC Protein of unknown function (DUF458) BT246_45120 ENOG4107IN1 Protein of unknown function (DUF1797) BT246_45150 ENOG4105EPM Diguanylate phosphodiesterase BT246_45160 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BT246_45190 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BT246_45210 ENOG4105UIN BT246_45300 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BT246_45340 ENOG4108HGU Histidine kinase BT246_45360 ENOG4105CHM Aminotransferase BT246_45370 ENOG4105FKQ transcriptional regulator BT246_45380 ENOG4105EG2 ABC transporter, permease BT246_45400 ENOG4107FKK extracellular solute-binding protein family 1 BT246_45430 ENOG4107FKK extracellular solute-binding protein family 1 BT246_45450 ENOG4105CG3 alpha amylase, catalytic region BT246_45540 ENOG4105CHU acetyl-coa acetyltransferase BT246_45610 ENOG4105K7K Transcriptional regulator BT246_45620 ENOG4105DTD Dehydrogenase BT246_45660 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BT246_45710 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BT246_45740 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BT246_45760 ENOG4105BZU Histidine kinase BT246_45800 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BT246_45830 ENOG4105CID antiterminator BT246_45850 ENOG4105FDP GntR family transcriptional regulator BT246_45870 ENOG4105CE4 GlcNAc 6-P deacetylase BT246_45940 ENOG4107ZE5 PPIases accelerate the folding of proteins BT246_45950 ENOG4105PTM secreted protein BT246_45960 ENOG4105J7I hydrolase BT246_45980 ENOG4105G6R Stage v sporulation protein ae BT246_46000 ENOG4105CZ3 stage V sporulation protein ad BT246_46010 ENOG41090VF Stage v sporulation protein ac BT246_46050 ENOG4105C8J )-transporter BT246_46060 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_46080 ENOG41082AN stage II sporulation protein BT246_46090 ENOG4105DZ1 carboxypeptidase BT246_46100 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BT246_46110 ENOG4105DVE abc transporter atp-binding protein BT246_46180 ENOG4105D7N magnesium and cobalt transport protein CorA BT246_46230 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BT246_46250 ENOG4105I3K Ferric uptake regulator, Fur family BT246_46260 ENOG4105MZ9 stage II sporulation protein m BT246_46300 ENOG4105CPC Aldo Keto reductase BT246_46320 ENOG4105RHY Pfam:UPF0157 BT246_46360 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BT246_46380 ENOG4105ETE Transcriptional regulator (LacI family BT246_46390 ENOG4108YM7 Gcn5-related n-acetyltransferase BT246_46440 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BT246_46450 ENOG4108R6K riboflavin synthase, subunit alpha BT246_46500 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BT246_46510 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BT246_46540 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BT246_46570 ENOG4105DFD Na H antiporter BT246_46580 ENOG4105CGH 5'-nucleotidase BT246_46630 ENOG4105DBV ornithine carbamoyltransferase BT246_46660 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BT246_46690 ENOG4108IXY short-chain dehydrogenase reductase BT246_46700 ENOG41069FQ Metallo-beta-lactamase superfamily BT246_46710 ENOG4105II7 pyrroline-5-carboxylate reductase BT246_46720 ENOG4105EJQ L-serine dehydratase BT246_46780 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BT246_46820 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BT246_46830 ENOG4105D9U N-acetyltransferase BT246_46850 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BT246_46860 ENOG4108QEG Membrane BT246_46870 ENOG4105CDA abc transporter atp-binding protein BT246_46880 ENOG4105E5Q amino acid AbC transporter BT246_46890 ENOG4108HW3 (ABC) transporter BT246_46910 ENOG4105G7B Protein of unknown function (DUF2992) BT246_46930 ENOG4108QY0 Membrane BT246_46950 ENOG4105C7S Dehydrogenase BT246_46960 ENOG4105CPP Dehydrogenase, E1 component BT246_46990 ENOG4105CKM Branched-chain carboxylic acid kinase BT246_47000 ENOG4107RDP Dehydrogenase BT246_47020 ENOG4108JUB Transcriptional regulator BT246_47040 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BT246_47070 ENOG4107QQR Sporulation BT246_47080 ENOG4105S1Z Stage IV sporulation protein B BT246_47090 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BT246_47100 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BT246_47110 ENOG4105DX0 Hemolysin A BT246_47130 ENOG4105CTB Polyprenyl synthetase BT246_47160 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BT246_47180 ENOG4108ZSR alkaline shock protein BT246_47190 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BT246_47240 ENOG410644B Stage III sporulation protein af BT246_47260 ENOG4105KQ4 Stage iii sporulation protein ad BT246_47270 ENOG4108CQH stage III sporulation protein AC BT246_47280 ENOG4105KR5 Stage iii sporulation protein BT246_47290 ENOG4105CD2 stage iii sporulation protein aa BT246_47340 ENOG4105DC7 peptidase M24 BT246_47350 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BT246_47370 ENOG4105CBJ Metal-dependent enzyme BT246_47390 ENOG4107YBY Hydrolase BT246_47450 ENOG41082GG biotin lipoate A B protein ligase BT246_47460 ENOG4105WZW rhodanese family BT246_47510 ENOG41080TC multidrug resistance protein BT246_47570 ENOG4105CJ1 ABC, transporter BT246_47580 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BT246_47640 ENOG4105C0D helicase BT246_47760 ENOG4106855 Competence protein BT246_47810 ENOG4107R6U sodium dicarboxylate symporter BT246_47880 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BT246_47890 ENOG4105C3R Methionine synthase BT246_47910 ENOG4105C28 cystathionine BT246_47920 ENOG4105C28 cystathionine BT246_47960 ENOG4105C5X domain protein BT246_47980 ENOG4105DKQ ROK family BT246_47990 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BT246_48030 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BT246_48040 ENOG4105C8U phosphate abc transporter BT246_48050 ENOG4105C8U phosphate abc transporter BT246_48060 ENOG4105EXS phosphate abc transporter BT246_48070 ENOG4107RF6 penicillin-binding protein BT246_48140 ENOG4105DQ6 Transposase BT246_48160 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BT246_48650 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BT246_48710 ENOG4105N80 Ferric uptake regulator, Fur family BT246_48730 ENOG4105FDK ABC transporter BT246_48740 ENOG4108JYZ YitT family BT246_48750 ENOG41069ZM Protein of unknown function (DUF2624) BT246_48800 ENOG4105EGD dinuclear metal center protein, YbgI family BT246_48830 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_48840 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BT246_48890 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BT246_48900 ENOG4105KG3 cytidine deaminase BT246_48910 ENOG4107YR5 Diacylglycerol kinase BT246_48920 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BT246_48930 ENOG4105CTJ Metal Dependent Phosphohydrolase BT246_48940 ENOG4105C9A Phoh family BT246_48960 ENOG41068P3 sporulation protein YqfC BT246_48980 ENOG4105KTH gatB Yqey BT246_49000 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BT246_49010 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BT246_49070 ENOG4105CSA Coproporphyrinogen iii oxidase BT246_49080 ENOG4105KVH Transcriptional regulator BT246_49130 ENOG4105TQK DNA polymerase iii, delta' subunit BT246_49150 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BT246_49160 ENOG4108UK2 deaminase BT246_49170 ENOG4105KQC Competence protein BT246_49190 ENOG4105DXX methyltransferase BT246_49210 ENOG4108WF2 Metal Dependent Phosphohydrolase BT246_49230 ENOG410812S Rna-binding protein BT246_49250 ENOG4105CQW ribosome biogenesis GTPase YqeH BT246_49260 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BT246_49290 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_49330 ENOG4108TVJ Nitroreductase BT246_49360 ENOG4105G6Z alkaline phosphatase BT246_49370 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BT246_49380 ENOG4108MUZ hydrolase BT246_49450 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BT246_49480 ENOG4105MIR Phenylalanine 4-monooxygenase BT246_49500 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BT246_49600 ENOG4105S6R Iron-hydroxamate transporter permease subunit BT246_49610 ENOG4108V5C ABC transporter BT246_49630 ENOG4108EKI Dehydrogenase BT246_49640 ENOG4105C28 cystathionine BT246_49700 ENOG4107XRG penicillin-binding protein BT246_49710 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BT246_49730 ENOG4105CFP Peptidase U32 BT246_49740 ENOG4105XYU peptidase (U32 family) BT246_49750 ENOG4108VQJ O-methyltransferase BT246_49760 ENOG4105HHA aminodeoxychorismate lyase BT246_49800 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BT246_49820 ENOG4105C02 permease BT246_49850 ENOG41060CR BT246_49860 ENOG4105C7H Helicase, RecD TraA family BT246_49880 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BT246_49890 ENOG4105C3J Cysteine desulfurase BT246_49910 ENOG4105D1H recombination factor protein RarA BT246_49920 ENOG4108VCI transcription factor, rsfa family BT246_49930 ENOG4105CUZ uba thif-type nad fad binding protein BT246_49950 ENOG4105CUT histidyl-tRNA synthetase BT246_50000 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BT246_50010 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BT246_50030 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BT246_50040 ENOG41076HS cation diffusion facilitator family transporter BT246_50050 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BT246_50070 ENOG4105CKP Polysaccharide Biosynthesis Protein BT246_50080 ENOG4108QG2 Membrane BT246_50100 ENOG4105VIE preprotein translocase, subunit YajC BT246_50130 ENOG41061AI Protein of unknown function (DUF2905) BT246_50160 ENOG4108HUF Transporter BT246_50230 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BT246_50240 ENOG4108IYU L-aspartate oxidase BT246_50270 ENOG4108RPX mosc domain containing protein BT246_50280 ENOG4105CQC Prephenate dehydratase BT246_50310 ENOG4105C19 ABC transporter BT246_50320 ENOG4105EWM Histidine kinase BT246_50340 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BT246_50370 ENOG4105X36 (ribosomal) protein BT246_50390 ENOG4105C03 ribonuclease BT246_50420 ENOG4107QMS site-determining protein BT246_50450 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BT246_50460 ENOG4105DFF Rod shape-determining protein mreb BT246_50500 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BT246_50510 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BT246_50540 ENOG41068KH stage VI sporulation protein D BT246_50560 ENOG4105D52 delta-aminolevulinic acid dehydratase BT246_50610 ENOG4105K56 Transcriptional regulator BT246_50650 ENOG4108IUQ atp-dependent protease BT246_50710 ENOG4108QCI YvbH-like oligomerisation region BT246_50780 ENOG4105M59 Phosphodiesterase, mj0936 family BT246_50810 ENOG4108XJQ germination protein BT246_50830 ENOG4105C57 major facilitator superfamily BT246_50850 ENOG4105KBX Transcriptional regulator, TetR family BT246_50870 ENOG4105PFC Transcriptional regulator BT246_50890 ENOG4105DZC cytosine deaminase BT246_50900 ENOG41067S9 phage shock protein C, PspC BT246_50910 ENOG4108JCI Transcriptional regulator BT246_50930 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BT246_50940 ENOG4108Z40 Transcriptional regulator BT246_50950 ENOG4105RHA ABC transporter, permease BT246_50960 ENOG4108IUX (ABC) transporter BT246_50970 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BT246_50980 ENOG4105ER2 Ompa motb domain protein BT246_50990 ENOG4105E14 MotA TolQ exbB proton channel BT246_51000 ENOG4108VXD carboxy-peptidase BT246_51020 ENOG4105E33 succinate dehydrogenase BT246_51040 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BT246_51060 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BT246_51070 ENOG4105K63 Thioredoxin BT246_51080 ENOG4105C10 Electron transfer flavoprotein BT246_51090 ENOG4105BZJ Electron transfer flavoprotein BT246_51100 ENOG41060WC Enoyl-CoA hydratase BT246_51110 ENOG4107Z3H Transcriptional regulator, TetR family BT246_51120 ENOG4105CEY Amp-dependent synthetase and ligase BT246_51150 ENOG4105J76 Periplasmic binding protein BT246_51160 ENOG4105S6R Iron-hydroxamate transporter permease subunit BT246_51260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BT246_51290 ENOG4105DR4 Methyltransferase BT246_51310 ENOG4105KFN sortase, SrtB family BT246_51320 ENOG4105E0A ABC, transporter BT246_51360 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BT246_51380 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BT246_51400 ENOG4105FE9 pseudouridine synthase BT246_51420 ENOG4105DCG PHP domain protein BT246_51450 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BT246_51480 ENOG4105C5S asparaginyl-tRNA synthetase BT246_51500 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BT246_51530 ENOG4108RWN rrna methyltransferase BT246_51590 ENOG4105C0R drug resistance transporter emrb qaca subfamily BT246_51600 ENOG4105CW7 secretion protein, HlyD family BT246_51610 ENOG4108JGH Tetr family transcriptional regulator BT246_51620 ENOG4105CN9 Peptidase m42 family protein BT246_51660 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BT246_51670 ENOG4105C22 threonyL-tRNA synthetase BT246_51680 ENOG4108TDW sporulation protein YtxC BT246_51730 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BT246_51740 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BT246_51750 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BT246_51770 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BT246_51780 ENOG4105C2M dna polymerase I BT246_51790 ENOG4105BZU Histidine kinase BT246_51800 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BT246_51850 ENOG4108HMX isocitrate dehydrogenase (NADP) BT246_51860 ENOG4105BZN citrate synthase BT246_51880 ENOG4108REF Sporulation integral membrane protein ytvi BT246_51890 ENOG4105FS0 cytoplasmic membrane protein BT246_51940 ENOG4105C6F GntR Family Transcriptional Regulator BT246_51950 ENOG4105C6K Malic enzyme BT246_51960 ENOG4105C0B DNA polymerase III (alpha subunit) BT246_51970 ENOG4105VV2 BT246_51990 ENOG4105SFS phosphoesterase RecJ domain protein BT246_52050 ENOG4105DC7 peptidase M24 BT246_52130 ENOG4105Z7P Acetyltransferase (GNAT) family BT246_52140 ENOG41082W1 Cupin 2, conserved barrel domain protein BT246_52180 ENOG4107YZX Universal stress protein BT246_52260 ENOG4108JYZ YitT family BT246_52310 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BT246_52330 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BT246_52340 ENOG4105KBJ sporulation protein ytfj BT246_52370 ENOG4105EFZ amidohydrolase BT246_52390 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BT246_52440 ENOG4105RQF LysR family Transcriptional regulator BT246_52460 ENOG4105U5Y Transcriptional regulator BT246_52480 ENOG4105C28 cystathionine BT246_52540 ENOG4108UW5 maltose o-acetyltransferase BT246_52560 ENOG4105F1V Acetoin utilization protein BT246_52570 ENOG4105W87 Cbs domain BT246_52580 ENOG4105DGU Histone deacetylase BT246_52610 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BT246_52620 ENOG4105BZU Histidine kinase BT246_52630 ENOG4107SNB ankyrin repeat protein YahD BT246_52640 ENOG4105EP9 oxidoreductase BT246_52690 ENOG4105ETE Transcriptional regulator (LacI family BT246_52700 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BT246_52740 ENOG4105C88 aminopeptidase BT246_52780 ENOG4108IPJ Membrane BT246_52850 ENOG4108VDD TRNA binding domain protein BT246_52910 ENOG4105C8F Beta-lactamase domain protein BT246_52940 ENOG4108V15 phosphotransferase enzyme family BT246_52950 ENOG4108IUM Glycogen debranching enzyme BT246_52970 ENOG4107QSE Dipeptidase BT246_52980 ENOG4105YW5 deoR family transcriptional regulator BT246_53010 ENOG4105CBX hi0933 family BT246_53090 ENOG4108VJ1 Transcriptional regulator (CarD family BT246_53100 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BT246_53110 ENOG4105CSC Glucose uptake protein BT246_53140 ENOG4108ZAF Molybdopterin BT246_53150 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BT246_53160 ENOG4105CVM Molybdenum cofactor synthesis domain protein BT246_53180 ENOG4105D06 uba thif-type nad fad binding protein BT246_53190 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BT246_53230 ENOG41085GJ domain protein BT246_53250 ENOG4105DWV Homoserine O-trans-acetylase BT246_53270 ENOG4108B31 Spore germination protein BT246_53320 ENOG4105C8T Leucyl-tRNA synthetase BT246_53340 ENOG410605W Major Facilitator BT246_53350 ENOG4107S91 Sodium hydrogen exchanger BT246_53360 ENOG4105NCW Trka-c domain protein BT246_53390 ENOG4105C19 ABC transporter BT246_53410 ENOG4105D7V transposase BT246_53460 ENOG4105N5T Radical SAM Protein BT246_53480 ENOG4105DA5 (ABC) transporter BT246_53540 ENOG4105E8V Alpha Beta Hydrolase Fold protein BT246_53550 ENOG4108Z0R Transferase BT246_53560 ENOG4105YVM Phosphoesterase, PA-phosphatase related BT246_53570 ENOG4105BZF Glycosyl transferase (Group 1 BT246_53590 ENOG4105EPU Molybdenum cofactor synthesis domain protein BT246_53730 ENOG4105BZU Histidine kinase BT246_53740 ENOG4105BZU Histidine kinase BT246_53750 ENOG4105CH6 catalase BT246_53770 ENOG4107S9D Alpha beta hydrolase BT246_53780 ENOG4107T7U Sulfatase BT246_53810 ENOG4105D2X ABC transporter substrate-binding protein BT246_53830 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BT246_53940 ENOG41080TC multidrug resistance protein BT246_53950 ENOG410839T multidrug resistance protein BT246_53990 ENOG4108V2W Carbonate dehydratase BT246_54000 ENOG4105C4M (Ubiquinol oxidase) subunit I BT246_54010 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BT246_54090 ENOG41087YS Phage shock protein A BT246_54150 ENOG4105BZU Histidine kinase BT246_54160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_54210 ENOG4108UGV hypoxanthine phosphoribosyltransferase BT246_54220 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BT246_54350 ENOG4107ZTW SNARE associated Golgi BT246_54380 ENOG4105C19 ABC transporter BT246_54390 ENOG41086D8 Transcriptional regulator BT246_54420 ENOG41082BM Transcriptional regulator, arsr family BT246_54520 ENOG4105C6Z Gluconate BT246_54530 ENOG4105FDP GntR family transcriptional regulator BT246_54570 ENOG41069H0 dihydroorotase EC 3.5.2.3 BT246_54620 ENOG4105DTQ mandelate racemase muconate lactonizing BT246_54630 ENOG4105CEY Amp-dependent synthetase and ligase BT246_54640 ENOG4108IPT Naphthoate synthase BT246_54650 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BT246_54660 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BT246_54670 ENOG4105E4F Isochorismate synthase BT246_54680 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BT246_54700 ENOG4105VEQ Cold shock protein BT246_54790 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BT246_54800 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BT246_54820 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BT246_55090 ENOG4105KT7 mgtC SapB transporter BT246_55100 ENOG4107PBV potassium channel BT246_55130 ENOG4105WG9 Conserved Protein BT246_55150 ENOG4105CHM Aminotransferase BT246_55160 ENOG4108ZB6 transcriptional regulator AsnC family BT246_55170 ENOG4105C5I Dehydrogenase BT246_55180 ENOG4108MUZ hydrolase BT246_55200 ENOG4105C87 Aminotransferase class I and II BT246_55240 ENOG4105Y38 Kinase-associated protein B BT246_55260 ENOG4107R3E Citrate transporter BT246_55290 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BT246_55300 ENOG4105KA0 thioesterase Superfamily protein BT246_55330 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BT246_55370 ENOG41069ER domain protein BT246_55400 ENOG4105CEP NADH dehydrogenase BT246_55460 ENOG4105EWC Purine nucleoside phosphorylase BT246_55500 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BT246_55790 ENOG4105WXW Antirepressor BT246_55800 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_55860 ENOG4105CDU Replicative dna helicase BT246_55880 ENOG4108PNI recT protein BT246_55890 ENOG4108NF7 phage-type endonuclease BT246_55940 ENOG4108IMY Transcriptional regulator BT246_56000 ENOG4108VQJ O-methyltransferase BT246_56040 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BT246_56080 ENOG4108JJA ABC, transporter BT246_56090 ENOG4105C4B ABC transporter, permease BT246_56100 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BT246_56160 ENOG41083MR nifu domain-containing protein BT246_56190 ENOG4108W5N phosphatidylglycerophosphatase a BT246_56230 ENOG4105DAX Pfam:DUF2983 BT246_56250 ENOG4105DYS nad(p)h dehydrogenase (quinone) BT246_56260 ENOG4105D4U had-superfamily hydrolase, subfamily iia BT246_56290 ENOG4105CBT Fructose-1,6-bisphosphatase BT246_56320 ENOG4105MMD transcriptional regulator BT246_56330 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BT246_56340 ENOG4107TXC Transcriptional regulator BT246_56350 ENOG41090T1 Membrane BT246_56400 ENOG4105FAA peptidase M23 BT246_56410 ENOG4108YTE sporulation protein YunB BT246_56420 ENOG4105KZD Domain of unknown function (DUF1805) BT246_56430 ENOG4107R8B 5'-nucleotidase BT246_56470 ENOG4108IBT Inherit from COG: transposase BT246_56510 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BT246_56520 ENOG4105XSJ toxin secretion phage lysis holin BT246_56750 ENOG4106E8G BT246_56940 ENOG4106050 phage regulatory protein, rha family BT246_56980 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BT246_56990 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BT246_57000 ENOG4105DIW FeS assembly protein SUFB BT246_57010 ENOG4108UNV SUF system FeS assembly protein, NifU family BT246_57020 ENOG4105C9B Cysteine desulfurase BT246_57030 ENOG4105JRK feS assembly protein SufD BT246_57040 ENOG4105C3K feS assembly ATPase SufC BT246_57050 ENOG4105D01 (LipO)protein BT246_57060 ENOG4105D01 (LipO)protein BT246_57070 ENOG4108UMI ABC transporter, permease BT246_57080 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BT246_57130 ENOG41080E8 Transcriptional regulator, Spx MgsR family BT246_57170 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BT246_57230 ENOG4108W8B Beta-lactamase domain protein BT246_57240 ENOG4105C1G acyl-Coa dehydrogenase BT246_57250 ENOG4105CHU acetyl-coa acetyltransferase BT246_57280 ENOG4105DZ1 carboxypeptidase BT246_57320 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BT246_57350 ENOG4108SUT Major Facilitator Superfamily BT246_57360 ENOG4107R7I amino acid BT246_57390 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BT246_57410 ENOG4107AYK membrAne BT246_57480 ENOG4107ZTW SNARE associated Golgi BT246_57500 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BT246_57510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_57520 ENOG4105BZU Histidine kinase BT246_57590 ENOG4105C8Q Methyl-accepting chemotaxis BT246_57600 ENOG4105C8Q Methyl-accepting chemotaxis BT246_57610 ENOG4105VG1 fes assembly suf system protein BT246_57620 ENOG4105D4Y metalloprotease BT246_57630 ENOG4105C2I pirin domain protein BT246_57660 ENOG4107T5V SNARE associated Golgi BT246_57670 ENOG4107S91 Sodium hydrogen exchanger BT246_57680 ENOG4105NCW Trka-c domain protein BT246_57710 ENOG4108RMU ferritin dps family protein BT246_57750 ENOG4108URH decarboxylase BT246_57770 ENOG41090A1 ferritin BT246_57790 ENOG4105D9N nucleoside BT246_57800 ENOG4105D9N nucleoside BT246_57830 ENOG4108RYK Nad-dependent epimerase dehydratase BT246_57900 ENOG4105CV8 reductase BT246_57910 ENOG4105F27 Major Facilitator BT246_57920 ENOG4105KVH Transcriptional regulator BT246_57950 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BT246_57960 ENOG4105D4A Cell wall formation (By similarity) BT246_57980 ENOG4105C8Q Methyl-accepting chemotaxis BT246_58000 ENOG4105WMR Protein CrcB homolog BT246_58010 ENOG4105WMR Protein CrcB homolog BT246_58040 ENOG4108MK9 spermidine N(1)-acetyltransferase BT246_58050 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BT246_58070 ENOG4108W2Y isochorismatase BT246_58130 ENOG4108IPW abc transporter atp-binding protein BT246_58140 ENOG4105CM4 permease protein BT246_58210 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BT246_58600 ENOG4105WXW Antirepressor BT246_58750 ENOG4105XZU Preprotein translocase, subunit SecG BT246_58760 ENOG41067MG lrgb family BT246_58860 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_58880 ENOG4105RHA ABC transporter, permease BT246_58890 ENOG4108IUX (ABC) transporter BT246_58900 ENOG4105BZU Histidine kinase BT246_58910 ENOG4108W5X Transcriptional Regulator, LuxR family BT246_58950 ENOG41090VF Stage v sporulation protein ac BT246_58960 ENOG4105CZ3 stage V sporulation protein ad BT246_58990 ENOG4108QY0 Membrane BT246_59000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BT246_59010 ENOG4105KRI phosphocarrier protein (HPr BT246_59030 ENOG4105CHW UPF0052 protein BT246_59040 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BT246_59050 ENOG4108Z4K mutator MutT protein BT246_59070 ENOG4105C3M thioredoxin reductase BT246_59090 ENOG4108S4C acetyltransferase BT246_59130 ENOG41086DT Membrane protein of unknown function BT246_59150 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BT246_59190 ENOG4107TXC Transcriptional regulator BT246_59230 ENOG4105DUM transcriptional regulator, lysR family BT246_59260 ENOG4108WS4 fmn reductase BT246_59270 ENOG4105C5H ABC transporter BT246_59290 ENOG4105BZ1 (ABC) transporter BT246_59310 ENOG4105CN1 protease BT246_59320 ENOG4105CRP Part of the ABC transporter FtsEX involved in BT246_59330 ENOG4105CAK Cell division ATP-binding protein ftsE BT246_59350 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BT246_59370 ENOG4105MS2 ribosomal subunit Interface protein BT246_59380 ENOG4105VEQ Cold shock protein BT246_59390 ENOG41081UC Inherit from COG: Competence protein BT246_59430 ENOG4107RBB ABC transporter, permease BT246_59440 ENOG4105C19 ABC transporter BT246_59500 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) BT246_59520 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BT246_59880 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BT246_59890 ENOG4108C33 Resolvase BT246_59910 ENOG4105K4H Nlp p60 protein BT246_59920 ENOG4105KVH Transcriptional regulator BT246_59940 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BT246_59950 ENOG4108KGH TRANSCRIPTIONal BT246_59960 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BT246_59970 ENOG4105C6Y Udp-glucose 6-dehydrogenase BT246_59980 ENOG4105ESV Glycosyl transferase, family 4 BT246_60000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BT246_60040 ENOG4105F8D glycoside hydrolase family 4 BT246_60050 ENOG4105VCP PTS System BT246_60060 ENOG4105CK1 PTS System BT246_60080 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BT246_60110 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BT246_60120 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BT246_60130 ENOG4105VCP PTS System BT246_60150 ENOG4105VZJ PTS System BT246_60190 ENOG4105ECB domain protein BT246_60200 ENOG4107RSM transcriptional regulator BT246_60280 ENOG4105DAA L-lactate BT246_60300 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BT246_60320 ENOG4105E0M Sulfatase BT246_60370 ENOG4107R8N Glycosyl transferase, family 2 BT246_60390 ENOG4105C94 Transporter BT246_60400 ENOG41069ER domain protein BT246_60450 ENOG4105KBK Zinc finger, swim domain protein BT246_60460 ENOG4105C0D helicase BT246_60520 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BT246_60540 ENOG4107RBB ABC transporter, permease BT246_60550 ENOG4105C19 ABC transporter BT246_60590 ENOG4105CXY transporter BT246_60630 ENOG4105BZU Histidine kinase BT246_60640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_60650 ENOG4105CMR udp-glucose 4-epimerase BT246_60670 ENOG4108KGH TRANSCRIPTIONal BT246_60700 ENOG4107QRS glycosyltransferase group 2 family protein BT246_60710 ENOG4107T8Q Glycosyl transferase (Group 1 BT246_60730 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BT246_60750 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BT246_60770 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BT246_60780 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BT246_60790 ENOG4107YJ4 chain length determinant protein BT246_60800 ENOG4105HTX biosynthesis protein BT246_60810 ENOG4107YJ4 chain length determinant protein BT246_60840 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BT246_60850 ENOG4105FRN stage II sporulation protein BT246_60880 ENOG4105DY9 regulatoR BT246_60920 ENOG4106778 Protein of unknown function (DUF1146) BT246_60930 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BT246_60940 ENOG4105C8S subunit m BT246_60950 ENOG4105D65 subunit l BT246_61000 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BT246_61010 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BT246_61040 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BT246_61060 ENOG4105BZU Histidine kinase BT246_61160 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BT246_61170 ENOG41062M3 atp synthase BT246_61200 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BT246_61210 ENOG4108UIC UPF0340 protein BT246_61220 ENOG4108YZG isomerase BT246_61250 ENOG4108VGI doxx family BT246_61260 ENOG4107XC4 flavin reductase domain protein, FMN-binding BT246_61300 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BT246_61320 ENOG4108ZXQ stage ii sporulation protein r BT246_61330 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BT246_61340 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BT246_61370 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BT246_61380 ENOG4105CBT Fructose-1,6-bisphosphatase BT246_61390 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BT246_61430 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BT246_61460 ENOG4105C1G acyl-Coa dehydrogenase BT246_61470 ENOG4105C1G acyl-Coa dehydrogenase BT246_61480 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BT246_61500 ENOG4105DF6 Fe-S oxidoreductase BT246_61550 ENOG4105BZU Histidine kinase BT246_61580 ENOG4105D4Y metalloprotease BT246_61600 ENOG4105BZU Histidine kinase BT246_61610 ENOG4105KCT ABC transporter BT246_61620 ENOG4108M15 ABC transporter BT246_61630 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BT246_61650 ENOG4105IIU Aminopeptidase BT246_61690 ENOG410684U Domain of unknown function (DUF1934) BT246_61730 ENOG4105CYW agmatinase BT246_61750 ENOG4105DXB Major Facilitator superfamily BT246_61760 ENOG4107SWG transcriptional regulator MERR family BT246_61770 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BT246_61780 ENOG4105BZ4 penicillin-binding protein BT246_61790 ENOG4108XFG YwhD family BT246_61800 ENOG4108Z4T Peptidase M50 BT246_61810 ENOG41069HH 4-oxalocrotonate tautomerase BT246_61820 ENOG4105DCI Phosphohydrolase BT246_61830 ENOG4108MES Periplasmic binding protein BT246_61840 ENOG4105E0A ABC, transporter BT246_61850 ENOG4105EHG Permease protein BT246_61860 ENOG4105DQ5 transport system permease protein BT246_61880 ENOG4108VCI transcription factor, rsfa family BT246_61890 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BT246_61900 ENOG4108IJ2 phosphate acetyltransferase BT246_61910 ENOG4107UEZ chlorite dismutase BT246_61930 ENOG4108VKI Cell wall hydrolase BT246_61970 ENOG4107SVH Potassium channel protein BT246_61990 ENOG410667J hydrolase BT246_62000 ENOG4105VCH membrane BT246_62020 ENOG4108TU7 Inherit from COG: (ABC) transporter BT246_62030 ENOG4105CJ1 ABC, transporter BT246_62040 ENOG41090WU lipolytic protein G-D-S-L family BT246_62090 ENOG4105D6E homoserine dehydrogenase BT246_62100 ENOG4105CVG Homoserine O-transsuccinylase BT246_62140 ENOG4108Y4K DNA-binding transcriptional activator BT246_62160 ENOG4105WH1 Two component transcriptional regulator luxr family BT246_62170 ENOG4105BZU Histidine kinase BT246_62180 ENOG4105DWF phosphomethylpyrimidine kinase BT246_62190 ENOG4105BZU Histidine kinase BT246_62200 ENOG4105VCD cytoplasmic protein BT246_62210 ENOG4105D22 carbon starvation protein BT246_62220 ENOG4105DY9 regulatoR BT246_62230 ENOG41079KZ Major Facilitator Superfamily BT246_62250 ENOG4105CG5 Glycosyl transferase (Group 1 BT246_62270 ENOG4105EN6 Membrane BT246_62280 ENOG4106YBV Methyl-accepting chemotaxis BT246_62300 ENOG4108S4H thioesterase Superfamily protein BT246_62310 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BT246_62340 ENOG4105K64 Glycosyl transferase, family 2 BT246_62370 ENOG4105CKK Glycosyl transferase, family 2 BT246_62400 ENOG4108IG5 Transcriptional regulator BT246_62410 ENOG4105C5H ABC transporter BT246_62420 ENOG41067SE Tetr family transcriptional regulator BT246_62440 ENOG4105E0X reductase BT246_62450 ENOG4106F5Q Membrane BT246_62510 ENOG4108NEV two component transcriptional regulator, LytTR family BT246_62540 ENOG4108HRK Histidine kinase BT246_62550 ENOG4107RGD Major Facilitator superfamily BT246_62580 ENOG4107RGD Major Facilitator superfamily BT246_62610 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BT246_62630 ENOG4105IW1 AmiS UreI transporter BT246_62650 ENOG4105CMR udp-glucose 4-epimerase BT246_62660 ENOG4108UT2 hemolysin iii BT246_62680 ENOG4105C1J atp-dependent rna helicase BT246_62690 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BT246_62700 ENOG4105DPN Oligoendopeptidase f BT246_62720 ENOG4105BZU Histidine kinase BT246_62760 ENOG4105C0H protease BT246_62770 ENOG4105Q2H domain protein BT246_62800 ENOG4105BZU Histidine kinase BT246_62810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_62860 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BT246_62870 ENOG4105CDU Replicative dna helicase BT246_62890 ENOG4105BZR domain protein BT246_62900 ENOG4108XMW Membrane BT246_62920 ENOG4108UUM single-stranded DNA-binding protein BT246_62940 ENOG4105C3G gtp-binding protein BT246_62950 ENOG4105VDK protein, conserved in bacteria BT246_62960 ENOG4105D8X mechanosensitive ion channel BT246_62970 ENOG4108ZDA Sporulation protein YyaC BT246_62980 ENOG4105FA0 parb-like partition protein BT246_62990 ENOG4107QJE Chromosome Partitioning Protein BT246_63030 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BT246_63040 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BT246_63060 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BT246_63590 ENOG4105YWU small acid-soluble spore protein BT246_63760 ENOG4108BUD transposase BT246_63920 ENOG4108IJ6 ABC transporter BT246_63970 ENOG4108BUD transposase BT246_63990 ENOG4105DQ6 Transposase BT246_64020 ENOG4108K8S endonuclease I BT246_64030 ENOG4108MK9 spermidine N(1)-acetyltransferase BT246_64040 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BT246_64090 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BT246_64270 ENOG4108IMY Transcriptional regulator BT246_64300 ENOG4105EKQ RNA-directed DNA polymerase BT246_64320 ENOG4105EKQ RNA-directed DNA polymerase BT246_64650 ENOG4108BUD transposase BT246_64670 ENOG4108BUD transposase BT246_64690 ENOG4105DQ6 Transposase BT246_64710 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BT246_64740 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BT246_64850 ENOG4108NHD germination protein BT246_64890 ENOG4108BUD transposase BT246_65000 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BT246_65080 ENOG4108BUD transposase BT246_65190 ENOG4105C19 ABC transporter BT246_65220 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BT246_65280 ENOG4105C19 ABC transporter BT246_65330 ENOG4108BUD transposase BT246_65570 ENOG4105K4H Nlp p60 protein BT246_65710 ENOG4105KRN Transcriptional regulator, abrb family BT246_65720 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BT246_65810 ENOG4108IMY Transcriptional regulator BT246_66110 ENOG4105CHH sulfate transporter BT246_66120 ENOG4108V2W Carbonate dehydratase BT246_66130 ENOG4108K8S endonuclease I BT246_66160 ENOG4108MK9 spermidine N(1)-acetyltransferase BT246_66210 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BT246_66270 ENOG4105G6Z alkaline phosphatase BT246_66390 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BT246_66440 ENOG4108BUD transposase BT246_66570 ENOG4108IMY Transcriptional regulator BT246_66740 ENOG4105MU5 relaxase mobilization nuclease domain protein BT246_66820 ENOG410836F Transposase BT246_66840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BT246_66850 ENOG4105BZU Histidine kinase BT246_66860 ENOG4107VMI polysaccharide deacetylase BT246_66890 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BT246_66930 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BT246_66960 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BT246_66980 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein BT246_67000 ENOG4105C19 ABC transporter BT246_67120 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BT246_67130 ENOG4105KRN Transcriptional regulator, abrb family BT246_67190 ENOG4107VMI polysaccharide deacetylase BT246_67350 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BT246_67380 ENOG4108BUD transposase BT246_67460 ENOG4105K70 DNA-binding protein BT246_67470 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BT246_67480 ENOG4105KRN Transcriptional regulator, abrb family BT246_67680 ENOG4108BUD transposase BT246_67790 ENOG4105K4H Nlp p60 protein BT246_67840 ENOG4108V2W Carbonate dehydratase BT246_67850 ENOG4105CHH sulfate transporter BT246_68290 ENOG4105K4H Nlp p60 protein BT246_68470 ENOG4105EKQ RNA-directed DNA polymerase BT246_68680 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BT246_68760 ENOG4105WFK nuclease BT246_68830 ENOG4105DVF Cytosine-specific methyltransferase BT246_68920 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BT246_69010 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BT246_69030 ENOG4105EXC Acyl-transferase BT246_69230 ENOG4108Q8B Spore germination protein BT246_69240 ENOG4108NHD germination protein BT246_69250 ENOG4105E1K spore germination protein BT246_69310 ENOG4108BUD transposase BT246_69370 ENOG4105DQ6 Transposase BT246_69500 ENOG4108BUD transposase BT246_69650 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BT246_69670 ENOG4105C0R drug resistance transporter emrb qaca subfamily BT246_69680 ENOG4105C26 Dehydrogenase BT246_69690 ENOG4105EMU Dehydrogenase BT246_69700 ENOG4108BUD transposase BT246_69770 ENOG4108BUD transposase BT246_69900 ENOG4108C33 Resolvase BT246_70090 ENOG4108BUD transposase BT246_70180 ENOG4105E4C Lytic transglycosylase catalytic BT246_70320 ENOG4108BUD transposase BT246_70340 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BT246_70350 ENOG4105BZ1 (ABC) transporter BT246_70360 ENOG4105BZ1 (ABC) transporter BT246_70380 ENOG4105C6Y Udp-glucose 6-dehydrogenase BT246_70390 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) BT246_70410 ENOG4105E2X shikimate dehydrogenase BT246_70450 ENOG4106J7S Glycosyl transferase, family 2 BT246_70460 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BT246_70590 ENOG4108BUD transposase BT246_70710 ENOG4107QJE Chromosome Partitioning Protein BT246_70780 ENOG4108BUD transposase BT246_71240 ENOG4105DQ6 Transposase BT246_71330 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BT246_71340 ENOG4105KRN Transcriptional regulator, abrb family BT246_71370 ENOG4105C9U ATP-dependent DNA helicase RecQ BT246_71460 ENOG4105K4H Nlp p60 protein BT246_71840 ENOG4105EKQ RNA-directed DNA polymerase BT246_71850 ENOG4105EKQ RNA-directed DNA polymerase BT246_71930 ENOG4105DQ6 Transposase BT246_72010 ENOG41067QW Transcriptional regulator BT246_72020 ENOG4108IMY Transcriptional regulator BT246_72130 ENOG4107QJE Chromosome Partitioning Protein BT246_72200 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis BT246_72870 ENOG41067QW Transcriptional regulator BT246_72990 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis