locus-tag class description BTXL6_00015 ENOG41067SE Tetr family transcriptional regulator BTXL6_00020 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity BTXL6_00045 ENOG4105BZU Histidine kinase BTXL6_00055 ENOG4105KT7 mgtC SapB transporter BTXL6_00070 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTXL6_00075 ENOG41073R8 VanW family BTXL6_00085 ENOG4108R1P BTXL6_00105 ENOG4105VEQ Cold shock protein BTXL6_00125 ENOG4105M6F mutator MutT protein BTXL6_00145 ENOG410904N short-chain dehydrogenase reductase BTXL6_00155 ENOG4106IQC argininosuccinate lyase BTXL6_00170 ENOG4108IA2 Sodium pantothenate symporter BTXL6_00180 ENOG4105C26 Dehydrogenase BTXL6_00185 ENOG4105CHR reductase BTXL6_00195 ENOG4105EWU Squalene--hopene cyclase BTXL6_00205 ENOG4105FR1 rard protein BTXL6_00210 ENOG410696E Membrane BTXL6_00225 ENOG4105D1F ATP-binding protein BTXL6_00235 ENOG4108ZAF Molybdopterin BTXL6_00240 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTXL6_00245 ENOG4105D06 uba thif-type nad fad binding protein BTXL6_00250 ENOG4105TMB Formate nitrite transporter BTXL6_00260 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTXL6_00265 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BTXL6_00275 ENOG4108JB9 formate dehydrogenase BTXL6_00285 ENOG4105E1K spore germination protein BTXL6_00300 ENOG4105CUB amino acid BTXL6_00360 ENOG4108KGH TRANSCRIPTIONal BTXL6_00370 ENOG4105EMN RNA polymerase sigma factor BTXL6_00385 ENOG4105CIG ABC transporter BTXL6_00405 ENOG4105D9R oxidoreductase BTXL6_00415 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BTXL6_00425 ENOG4105K4P CoA-binding domain protein BTXL6_00430 ENOG4105C0H protease BTXL6_00435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_00440 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BTXL6_00445 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BTXL6_00455 ENOG4105W8X HesB YadR YfhF-family protein BTXL6_00485 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTXL6_00490 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTXL6_00500 ENOG4108JJA ABC, transporter BTXL6_00505 ENOG4108I0Z Aconitate hydratase BTXL6_00535 ENOG4105E5W Transporter BTXL6_00545 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTXL6_00565 ENOG4107F3J Amp-dependent synthetase and ligase BTXL6_00570 ENOG4107ZYJ bioY protein BTXL6_00575 ENOG4105CEY Amp-dependent synthetase and ligase BTXL6_00590 ENOG4108IMY Transcriptional regulator BTXL6_00640 ENOG4107AYK membrAne BTXL6_00650 ENOG4105BZU Histidine kinase BTXL6_00655 ENOG4105FBA Phospholipase Carboxylesterase BTXL6_00660 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BTXL6_00665 ENOG4105CK7 Sodium proline symporter BTXL6_00675 ENOG4105CBC glutamate synthase BTXL6_00680 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BTXL6_00685 ENOG4108VJ1 Transcriptional regulator (CarD family BTXL6_00690 ENOG4108903 Formimidoylglutamase BTXL6_00715 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) BTXL6_00750 ENOG4107QIV Cytochrome c biogenesis protein BTXL6_00760 ENOG4105CH2 amidohydrolase BTXL6_00770 ENOG4105CJ1 ABC, transporter BTXL6_00780 ENOG4107RSM transcriptional regulator BTXL6_00790 ENOG41067MG lrgb family BTXL6_00815 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTXL6_00830 ENOG4105BZ1 (ABC) transporter BTXL6_00835 ENOG4105BZ1 (ABC) transporter BTXL6_00875 ENOG4108HW3 (ABC) transporter BTXL6_00880 ENOG4105CGH 5'-nucleotidase BTXL6_00890 ENOG4108SVB resolvase BTXL6_00910 ENOG4105K7K Transcriptional regulator BTXL6_00940 ENOG4105C5F glutamine synthetase BTXL6_00945 ENOG4105KV4 Transcriptional regulator BTXL6_00950 ENOG4105CXI aluminum resistance protein BTXL6_00955 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTXL6_00960 ENOG4105EN6 Membrane BTXL6_00970 ENOG4106F1P AAA ATPase, central domain protein BTXL6_01000 ENOG41069ER domain protein BTXL6_01005 ENOG4105DM4 PTS System BTXL6_01010 ENOG4105DE4 1-phosphofructokinase BTXL6_01015 ENOG4105E98 transcriptional regulator DeoR family BTXL6_01020 ENOG4107QW4 alcohol dehydrogenase BTXL6_01025 ENOG4108SJC Membrane BTXL6_01040 ENOG4105C85 amino acid BTXL6_01055 ENOG4105TMB Formate nitrite transporter BTXL6_01060 ENOG4105K70 DNA-binding protein BTXL6_01070 ENOG4105C59 p-type ATPase BTXL6_01075 ENOG410681U heavy metal transport detoxification protein BTXL6_01080 ENOG4105VPX protein, conserved in bacteria BTXL6_01090 ENOG4105NIV Esterase BTXL6_01095 ENOG4105E0A ABC, transporter BTXL6_01115 ENOG4105CGK Exodeoxyribonuclease III BTXL6_01125 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BTXL6_01130 ENOG4105D03 DNA-3-methyladenine glycosylase II BTXL6_01160 ENOG4105BZU Histidine kinase BTXL6_01180 ENOG4105C5E polysaccharide biosynthesis protein BTXL6_01195 ENOG4107ZY0 Phenazine biosynthesis-like protein BTXL6_01205 ENOG41067MG lrgb family BTXL6_01235 ENOG4105F0V Cell wall hydrolase BTXL6_01245 ENOG4105E0M Sulfatase BTXL6_01250 ENOG410890F Dynamin family BTXL6_01260 ENOG4107QHE Choloylglycine hydrolase BTXL6_01285 ENOG4105DA5 (ABC) transporter BTXL6_01315 ENOG4105DQU oxidoreductase, subunit beta BTXL6_01320 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BTXL6_01325 ENOG4108IGT Dipeptidase BTXL6_01330 ENOG4105MCT stage V sporulation protein S BTXL6_01335 ENOG4105D48 metallophosphoesterase BTXL6_01360 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BTXL6_01375 ENOG4105XZV Protein of unknown function (DUF3243) BTXL6_01380 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BTXL6_01400 ENOG4105UIB (ABC) transporter BTXL6_01405 ENOG4108JQ9 ABC transporter BTXL6_01410 ENOG4105DIH basic membrane BTXL6_01415 ENOG4105FDP GntR family transcriptional regulator BTXL6_01420 ENOG4107QZI cell division protein FtsK BTXL6_01430 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BTXL6_01445 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTXL6_01455 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTXL6_01460 ENOG4108S0H Dipicolinic acid synthetase, b subunit BTXL6_01465 ENOG4105E35 Dipicolinate synthase subunit A BTXL6_01475 ENOG4105C1V Peptidase, M16 BTXL6_01495 ENOG4105DTN riboflavin biosynthesis protein ribF BTXL6_01510 ENOG4105W7A Protein of unknown function (DUF503) BTXL6_01520 ENOG4105VHM ribosomal protein BTXL6_01525 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BTXL6_01530 ENOG4105CHV Transcription elongation factor NusA BTXL6_01540 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BTXL6_01550 ENOG4105DZP Membrane-associated zinc metalloprotease BTXL6_01560 ENOG4105KNE Phosphatidate cytidylyltransferase BTXL6_01605 ENOG4108HE4 integrase family BTXL6_01615 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BTXL6_01620 ENOG4105C79 DNA protecting protein DprA BTXL6_01625 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BTXL6_01640 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BTXL6_01665 ENOG4105VB6 UPF0109 protein BTXL6_01685 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BTXL6_01690 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BTXL6_01705 ENOG4105CHR reductase BTXL6_01710 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BTXL6_01725 ENOG4105CB5 ATP-dependent DNA helicase recG BTXL6_01730 ENOG4105DP4 dak2 domain fusion protein ylov BTXL6_01735 ENOG4108ZAA Alkaline-shock protein BTXL6_01750 ENOG4105FJ0 thiamine BTXL6_01755 ENOG4105DJV ribulose-phosphate 3-epimerase BTXL6_01765 ENOG4105D9P serine threonine protein kinase BTXL6_01770 ENOG4108ZF3 Phosphatase BTXL6_01780 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BTXL6_01790 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BTXL6_01795 ENOG4105C25 Primosomal protein n' BTXL6_01800 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BTXL6_01820 ENOG4105DSJ YicC domain protein BTXL6_01830 ENOG4105F23 Fibronectin-binding protein BTXL6_01840 ENOG4105DC7 peptidase M24 BTXL6_01920 ENOG4105C34 Pseudouridine synthase BTXL6_01945 ENOG4105DBK s4 domain protein BTXL6_01950 ENOG41067XK integral membrane protein BTXL6_01960 ENOG4105DFA alanine racemase domain protein BTXL6_01965 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BTXL6_01970 ENOG4105WR5 sporulation protein, YlmC YmxH family BTXL6_01980 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTXL6_01990 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BTXL6_01995 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BTXL6_02000 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BTXL6_02010 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BTXL6_02015 ENOG4105CNI cell division protein FtsW BTXL6_02030 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BTXL6_02035 ENOG4105CJN penicillin-binding protein BTXL6_02040 ENOG4105CJN penicillin-binding protein BTXL6_02045 ENOG41068DC Essential cell division protein (By similarity) BTXL6_02080 ENOG4105KNH Nucleic acid-binding protein BTXL6_02090 ENOG41063PX domain protein BTXL6_02095 ENOG4105D78 K07001 NTE family protein BTXL6_02100 ENOG4105H20 Sporulation integral membrane protein YlbJ BTXL6_02110 ENOG4106H78 methyltransferase BTXL6_02130 ENOG4107TB6 phosphoglycerate mutase BTXL6_02145 ENOG4106UY4 Inherit from COG: Scp-like extracellular BTXL6_02190 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BTXL6_02195 ENOG4105CNI cell division protein FtsW BTXL6_02210 ENOG4108IAB Phoh family BTXL6_02230 ENOG4105QA2 BTXL6_02235 ENOG4105CI3 gtp-binding protein typa BTXL6_02245 ENOG4105ECY inositol monophosphatase BTXL6_02265 ENOG4105CXN decarboxylase BTXL6_02315 ENOG4105CPP Dehydrogenase, E1 component BTXL6_02330 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BTXL6_02335 ENOG4108X4Q Hydrolase BTXL6_02345 ENOG4105CN5 Metallo-Beta-Lactamase BTXL6_02350 ENOG4107ZYR domain protein BTXL6_02385 ENOG4108XRC Protein of unknown function (DUF458) BTXL6_02395 ENOG4107IN1 Protein of unknown function (DUF1797) BTXL6_02410 ENOG4105EPM Diguanylate phosphodiesterase BTXL6_02415 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BTXL6_02430 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BTXL6_02440 ENOG4105UIN BTXL6_02505 ENOG4108HGU Histidine kinase BTXL6_02515 ENOG4105CHM Aminotransferase BTXL6_02520 ENOG4105FKQ transcriptional regulator BTXL6_02525 ENOG4105EG2 ABC transporter, permease BTXL6_02535 ENOG4107FKK extracellular solute-binding protein family 1 BTXL6_02545 ENOG4105CG3 alpha amylase, catalytic region BTXL6_02585 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BTXL6_02590 ENOG4105CHU acetyl-coa acetyltransferase BTXL6_02625 ENOG4105K7K Transcriptional regulator BTXL6_02630 ENOG4105DTD Dehydrogenase BTXL6_02645 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BTXL6_02685 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTXL6_02695 ENOG4105BZU Histidine kinase BTXL6_02715 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BTXL6_02730 ENOG4105CID antiterminator BTXL6_02740 ENOG4105FDP GntR family transcriptional regulator BTXL6_02750 ENOG4105CE4 GlcNAc 6-P deacetylase BTXL6_02795 ENOG4107ZE5 PPIases accelerate the folding of proteins BTXL6_02800 ENOG4105PTM secreted protein BTXL6_02805 ENOG4105J7I hydrolase BTXL6_02815 ENOG4105G6R Stage v sporulation protein ae BTXL6_02825 ENOG4105CZ3 stage V sporulation protein ad BTXL6_02830 ENOG41090VF Stage v sporulation protein ac BTXL6_02850 ENOG4105C8J )-transporter BTXL6_02855 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTXL6_02865 ENOG41082AN stage II sporulation protein BTXL6_02870 ENOG4105DZ1 carboxypeptidase BTXL6_02875 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTXL6_02880 ENOG4105DVE abc transporter atp-binding protein BTXL6_02920 ENOG4105D7N magnesium and cobalt transport protein CorA BTXL6_02945 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTXL6_02955 ENOG4105I3K Ferric uptake regulator, Fur family BTXL6_02960 ENOG4105MZ9 stage II sporulation protein m BTXL6_02980 ENOG4105CPC Aldo Keto reductase BTXL6_02990 ENOG4105RHY Pfam:UPF0157 BTXL6_03010 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BTXL6_03020 ENOG4105ETE Transcriptional regulator (LacI family BTXL6_03025 ENOG4108YM7 Gcn5-related n-acetyltransferase BTXL6_03045 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BTXL6_03050 ENOG4108R6K riboflavin synthase, subunit alpha BTXL6_03070 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BTXL6_03075 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTXL6_03080 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTXL6_03095 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTXL6_03105 ENOG4105DFD Na H antiporter BTXL6_03110 ENOG4105CGH 5'-nucleotidase BTXL6_03165 ENOG4108IXY short-chain dehydrogenase reductase BTXL6_03170 ENOG41069FQ Metallo-beta-lactamase superfamily BTXL6_03175 ENOG4105II7 pyrroline-5-carboxylate reductase BTXL6_03180 ENOG4105EJQ L-serine dehydratase BTXL6_03210 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BTXL6_03220 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BTXL6_03225 ENOG4105D9U N-acetyltransferase BTXL6_03240 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BTXL6_03245 ENOG4108QEG Membrane BTXL6_03250 ENOG4105CDA abc transporter atp-binding protein BTXL6_03255 ENOG4105E5Q amino acid AbC transporter BTXL6_03260 ENOG4108HW3 (ABC) transporter BTXL6_03270 ENOG4105G7B Protein of unknown function (DUF2992) BTXL6_03280 ENOG4108QY0 Membrane BTXL6_03295 ENOG4105C7S Dehydrogenase BTXL6_03300 ENOG4105CPP Dehydrogenase, E1 component BTXL6_03315 ENOG4105CKM Branched-chain carboxylic acid kinase BTXL6_03320 ENOG4107RDP Dehydrogenase BTXL6_03335 ENOG4108JUB Transcriptional regulator BTXL6_03345 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTXL6_03360 ENOG4107QQR Sporulation BTXL6_03370 ENOG4105S1Z Stage IV sporulation protein B BTXL6_03375 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BTXL6_03385 ENOG4105DX0 Hemolysin A BTXL6_03395 ENOG4105CTB Polyprenyl synthetase BTXL6_03420 ENOG4108ZSR alkaline shock protein BTXL6_03425 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTXL6_03450 ENOG410644B Stage III sporulation protein af BTXL6_03460 ENOG4105KQ4 Stage iii sporulation protein ad BTXL6_03465 ENOG4108CQH stage III sporulation protein AC BTXL6_03470 ENOG4105KR5 Stage iii sporulation protein BTXL6_03475 ENOG4105CD2 stage iii sporulation protein aa BTXL6_03500 ENOG4105DC7 peptidase M24 BTXL6_03515 ENOG4105CBJ Metal-dependent enzyme BTXL6_03525 ENOG4107YBY Hydrolase BTXL6_03560 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BTXL6_03565 ENOG4105WZW rhodanese family BTXL6_03590 ENOG41080TC multidrug resistance protein BTXL6_03635 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BTXL6_03665 ENOG4105C0D helicase BTXL6_03760 ENOG4105XSJ toxin secretion phage lysis holin BTXL6_03840 ENOG4105CAR Terminase, large subunit BTXL6_03880 ENOG410682Q Phage transcriptional regulator, ArpU BTXL6_03940 ENOG4105KRN Transcriptional regulator, abrb family BTXL6_04080 ENOG4105C3R Methionine synthase BTXL6_04090 ENOG4105C28 cystathionine BTXL6_04095 ENOG4105C28 cystathionine BTXL6_04115 ENOG4105C5X domain protein BTXL6_04125 ENOG4105DKQ ROK family BTXL6_04135 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BTXL6_04150 ENOG4108UTW Plays a role in the regulation of phosphate uptake BTXL6_04155 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BTXL6_04160 ENOG4105E2Z phosphate ABC transporter (Permease BTXL6_04165 ENOG4105C8U phosphate abc transporter BTXL6_04170 ENOG4105PWN phosphate abc transporter BTXL6_04175 ENOG4107RF6 penicillin-binding protein BTXL6_04185 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTXL6_04215 ENOG4105N80 Ferric uptake regulator, Fur family BTXL6_04225 ENOG4105FDK ABC transporter BTXL6_04230 ENOG4108JYZ YitT family BTXL6_04235 ENOG41069ZM Protein of unknown function (DUF2624) BTXL6_04260 ENOG4105EGD dinuclear metal center protein, YbgI family BTXL6_04275 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTXL6_04280 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BTXL6_04315 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BTXL6_04320 ENOG4105KG3 cytidine deaminase BTXL6_04325 ENOG4107YR5 Diacylglycerol kinase BTXL6_04335 ENOG4105CTJ Metal Dependent Phosphohydrolase BTXL6_04340 ENOG4105C9A Phoh family BTXL6_04355 ENOG41068P3 sporulation protein YqfC BTXL6_04360 ENOG4105KTH gatB Yqey BTXL6_04370 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BTXL6_04375 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BTXL6_04405 ENOG4105CSA Coproporphyrinogen iii oxidase BTXL6_04410 ENOG4105KVH Transcriptional regulator BTXL6_04435 ENOG4105TQK DNA polymerase iii, delta' subunit BTXL6_04445 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BTXL6_04450 ENOG4108UK2 deaminase BTXL6_04455 ENOG4105KQC Competence protein BTXL6_04465 ENOG4105DXX methyltransferase BTXL6_04475 ENOG4108WF2 Metal Dependent Phosphohydrolase BTXL6_04485 ENOG410812S Rna-binding protein BTXL6_04495 ENOG4105CQW ribosome biogenesis GTPase YqeH BTXL6_04500 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BTXL6_04515 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTXL6_04530 ENOG4108TVJ Nitroreductase BTXL6_04545 ENOG4105G6Z alkaline phosphatase BTXL6_04555 ENOG4108MUZ hydrolase BTXL6_04590 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTXL6_04595 ENOG4105MIR Phenylalanine 4-monooxygenase BTXL6_04605 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BTXL6_04645 ENOG4105S6R Iron-hydroxamate transporter permease subunit BTXL6_04650 ENOG4108V5C ABC transporter BTXL6_04660 ENOG4108EKI Dehydrogenase BTXL6_04665 ENOG4105C28 cystathionine BTXL6_04695 ENOG4107XRG penicillin-binding protein BTXL6_04710 ENOG4105CFP Peptidase U32 BTXL6_04715 ENOG4105XYU peptidase (U32 family) BTXL6_04720 ENOG4108VQJ O-methyltransferase BTXL6_04725 ENOG4105HHA aminodeoxychorismate lyase BTXL6_04755 ENOG4105C02 permease BTXL6_04770 ENOG41060CR BTXL6_04775 ENOG4105C7H Helicase, RecD TraA family BTXL6_04790 ENOG4105C3J Cysteine desulfurase BTXL6_04800 ENOG4105D1H recombination factor protein RarA BTXL6_04805 ENOG4108VCI transcription factor, rsfa family BTXL6_04815 ENOG4105CUZ uba thif-type nad fad binding protein BTXL6_04825 ENOG4105CUT histidyl-tRNA synthetase BTXL6_04840 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BTXL6_04850 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BTXL6_04855 ENOG41076HS cation diffusion facilitator family transporter BTXL6_04860 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BTXL6_04870 ENOG4105CKP Polysaccharide Biosynthesis Protein BTXL6_04875 ENOG4108QG2 Membrane BTXL6_04885 ENOG4105VIE preprotein translocase, subunit YajC BTXL6_04900 ENOG41061AI Protein of unknown function (DUF2905) BTXL6_04915 ENOG4108HUF Transporter BTXL6_04925 ENOG4108IPJ Membrane BTXL6_04930 ENOG41082BM Transcriptional regulator, arsr family BTXL6_04955 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BTXL6_04960 ENOG4108IYU L-aspartate oxidase BTXL6_04975 ENOG4108RPX mosc domain containing protein BTXL6_04980 ENOG4105CQC Prephenate dehydratase BTXL6_04995 ENOG4105C19 ABC transporter BTXL6_05000 ENOG4105EWM Histidine kinase BTXL6_05010 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BTXL6_05025 ENOG4105X36 (ribosomal) protein BTXL6_05035 ENOG4105C03 ribonuclease BTXL6_05050 ENOG4107QMS site-determining protein BTXL6_05065 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BTXL6_05070 ENOG4105DFF Rod shape-determining protein mreb BTXL6_05090 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BTXL6_05105 ENOG41068KH stage VI sporulation protein D BTXL6_05115 ENOG4105D52 delta-aminolevulinic acid dehydratase BTXL6_05140 ENOG4105K56 Transcriptional regulator BTXL6_05160 ENOG4108IUQ atp-dependent protease BTXL6_05190 ENOG4108QCI YvbH-like oligomerisation region BTXL6_05210 ENOG4105M59 Phosphodiesterase, mj0936 family BTXL6_05215 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BTXL6_05225 ENOG4108XJQ germination protein BTXL6_05235 ENOG4108PCX Major Facilitator BTXL6_05245 ENOG4105KBX Transcriptional regulator, TetR family BTXL6_05260 ENOG4105PFC Transcriptional regulator BTXL6_05275 ENOG4105DZC cytosine deaminase BTXL6_05280 ENOG4105DZC cytosine deaminase BTXL6_05290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTXL6_05305 ENOG4108JQ7 (ABC) transporter BTXL6_05310 ENOG4108HRK Histidine kinase BTXL6_05315 ENOG4105DY9 regulatoR BTXL6_05325 ENOG41067S9 phage shock protein C, PspC BTXL6_05330 ENOG4108JCI Transcriptional regulator BTXL6_05340 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BTXL6_05345 ENOG4108Z40 Transcriptional regulator BTXL6_05350 ENOG4105RHA ABC transporter, permease BTXL6_05355 ENOG4108IUX (ABC) transporter BTXL6_05360 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family BTXL6_05365 ENOG4105ER2 Ompa motb domain protein BTXL6_05370 ENOG4105E14 MotA TolQ exbB proton channel BTXL6_05375 ENOG4108VXD carboxy-peptidase BTXL6_05385 ENOG4105E33 succinate dehydrogenase BTXL6_05395 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BTXL6_05410 ENOG4105K63 Thioredoxin BTXL6_05415 ENOG4105C10 Electron transfer flavoprotein BTXL6_05420 ENOG4105BZJ Electron transfer flavoprotein BTXL6_05425 ENOG41060WC Enoyl-CoA hydratase BTXL6_05430 ENOG4107Z3H Transcriptional regulator, TetR family BTXL6_05435 ENOG4105CEY Amp-dependent synthetase and ligase BTXL6_05485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTXL6_05500 ENOG4105DR4 Methyltransferase BTXL6_05510 ENOG4105KFN sortase, SrtB family BTXL6_05515 ENOG4105E0A ABC, transporter BTXL6_05530 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BTXL6_05540 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BTXL6_05550 ENOG4105FE9 pseudouridine synthase BTXL6_05565 ENOG4105DCG PHP domain protein BTXL6_05580 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BTXL6_05600 ENOG4105C5S asparaginyl-tRNA synthetase BTXL6_05605 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BTXL6_05615 ENOG4108RWN rrna methyltransferase BTXL6_05635 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTXL6_05640 ENOG4105CW7 secretion protein, HlyD family BTXL6_05645 ENOG4108JGH Tetr family transcriptional regulator BTXL6_05650 ENOG4105CN9 Peptidase m42 family protein BTXL6_05670 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BTXL6_05675 ENOG4105C22 threonyL-tRNA synthetase BTXL6_05680 ENOG4108TDW sporulation protein YtxC BTXL6_05700 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BTXL6_05705 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BTXL6_05710 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BTXL6_05725 ENOG4105C2M dna polymerase I BTXL6_05730 ENOG4105BZU Histidine kinase BTXL6_05735 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTXL6_05755 ENOG4108HMX isocitrate dehydrogenase (NADP) BTXL6_05760 ENOG4105BZN citrate synthase BTXL6_05775 ENOG4108REF Sporulation integral membrane protein ytvi BTXL6_05780 ENOG4105FS0 cytoplasmic membrane protein BTXL6_05805 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTXL6_05810 ENOG4105C6K Malic enzyme BTXL6_05815 ENOG4105C0B DNA polymerase III (alpha subunit) BTXL6_05820 ENOG4105VV2 BTXL6_05830 ENOG4105SFS phosphoesterase RecJ domain protein BTXL6_05870 ENOG4105DC7 peptidase M24 BTXL6_05905 ENOG4105Z7P Acetyltransferase (GNAT) family BTXL6_05910 ENOG41082W1 Cupin 2, conserved barrel domain protein BTXL6_05920 ENOG4105VZ8 Transcriptional regulator BTXL6_05940 ENOG4107YZX Universal stress protein BTXL6_05975 ENOG4108JYZ YitT family BTXL6_06005 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BTXL6_06010 ENOG4105KBJ sporulation protein ytfj BTXL6_06025 ENOG4105EFZ amidohydrolase BTXL6_06035 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTXL6_06060 ENOG4106KR7 LysR family Transcriptional regulator BTXL6_06070 ENOG4105U5Y Transcriptional regulator BTXL6_06080 ENOG4105C28 cystathionine BTXL6_06100 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BTXL6_06110 ENOG4105EMN RNA polymerase sigma factor BTXL6_06130 ENOG4105F1V Acetoin utilization protein BTXL6_06135 ENOG4105W87 Cbs domain BTXL6_06140 ENOG4105DGU Histone deacetylase BTXL6_06145 ENOG4106HB6 Alpha beta hydrolase BTXL6_06155 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTXL6_06160 ENOG4105BZU Histidine kinase BTXL6_06165 ENOG4107SNB ankyrin repeat protein YahD BTXL6_06170 ENOG4105EP9 oxidoreductase BTXL6_06200 ENOG4105ETE Transcriptional regulator (LacI family BTXL6_06225 ENOG4105C88 aminopeptidase BTXL6_06245 ENOG4108IPJ Membrane BTXL6_06255 ENOG4105K7K Transcriptional regulator BTXL6_06290 ENOG4108VDD TRNA binding domain protein BTXL6_06320 ENOG4105C8F Beta-lactamase domain protein BTXL6_06335 ENOG4108V15 phosphotransferase enzyme family BTXL6_06340 ENOG4108IUM Glycogen debranching enzyme BTXL6_06355 ENOG4107QSE Dipeptidase BTXL6_06360 ENOG4105YW5 deoR family transcriptional regulator BTXL6_06375 ENOG4105CBX hi0933 family BTXL6_06410 ENOG4108VJ1 Transcriptional regulator (CarD family BTXL6_06415 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BTXL6_06435 ENOG4108ZAF Molybdopterin BTXL6_06440 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BTXL6_06445 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTXL6_06455 ENOG4105D06 uba thif-type nad fad binding protein BTXL6_06460 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTXL6_06480 ENOG41085GJ domain protein BTXL6_06490 ENOG4105DWV Homoserine O-trans-acetylase BTXL6_06500 ENOG4108B31 Spore germination protein BTXL6_06530 ENOG410605W Major Facilitator BTXL6_06535 ENOG4107S91 Sodium hydrogen exchanger BTXL6_06540 ENOG4105NCW Trka-c domain protein BTXL6_06555 ENOG4105C19 ABC transporter BTXL6_06575 ENOG4105N5T Radical SAM Protein BTXL6_06585 ENOG4105CIG ABC transporter BTXL6_06620 ENOG4105E8V Alpha Beta Hydrolase Fold protein BTXL6_06625 ENOG4108Z0R Transferase BTXL6_06630 ENOG4105YVM Phosphoesterase, PA-phosphatase related BTXL6_06635 ENOG4105BZF Glycosyl transferase (Group 1 BTXL6_06645 ENOG4108RIR Molybdenum cofactor biosynthesis protein BTXL6_06660 ENOG4108MK9 spermidine N(1)-acetyltransferase BTXL6_06725 ENOG4105BZU Histidine kinase BTXL6_06730 ENOG4105BZU Histidine kinase BTXL6_06735 ENOG4107S9D Alpha beta hydrolase BTXL6_06740 ENOG4107T7U Sulfatase BTXL6_06755 ENOG4105D2X ABC transporter substrate-binding protein BTXL6_06765 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BTXL6_06825 ENOG4108V2W Carbonate dehydratase BTXL6_06830 ENOG4105C4M (Ubiquinol oxidase) subunit I BTXL6_06835 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTXL6_06885 ENOG41087YS Phage shock protein A BTXL6_06920 ENOG4105BZU Histidine kinase BTXL6_06925 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_06950 ENOG4108UGV hypoxanthine phosphoribosyltransferase BTXL6_06955 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BTXL6_06970 ENOG4108HVR ABC transporter, permease BTXL6_06995 ENOG4107ZTW SNARE associated Golgi BTXL6_07020 ENOG4105C19 ABC transporter BTXL6_07025 ENOG41086D8 Transcriptional regulator BTXL6_07035 ENOG41082BM Transcriptional regulator, arsr family BTXL6_07085 ENOG4105C6Z Gluconate BTXL6_07090 ENOG4105FDP GntR family transcriptional regulator BTXL6_07110 ENOG41069H0 dihydroorotase EC 3.5.2.3 BTXL6_07130 ENOG4105DTQ mandelate racemase muconate lactonizing BTXL6_07145 ENOG4108IPT Naphthoate synthase BTXL6_07150 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BTXL6_07160 ENOG4105E4F Isochorismate synthase BTXL6_07165 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTXL6_07175 ENOG4105VEQ Cold shock protein BTXL6_07230 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTXL6_07235 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTXL6_07340 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BTXL6_07375 ENOG4105KT7 mgtC SapB transporter BTXL6_07380 ENOG4107PBV potassium channel BTXL6_07400 ENOG4105WG9 Conserved Protein BTXL6_07410 ENOG4105CHM Aminotransferase BTXL6_07415 ENOG4108ZB6 transcriptional regulator AsnC family BTXL6_07420 ENOG4105C5I Dehydrogenase BTXL6_07425 ENOG4108MUZ hydrolase BTXL6_07435 ENOG4105C87 Aminotransferase class I and II BTXL6_07450 ENOG4105Y38 Kinase-associated protein B BTXL6_07460 ENOG4107R3E Citrate transporter BTXL6_07475 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) BTXL6_07480 ENOG4105KA0 thioesterase Superfamily protein BTXL6_07495 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTXL6_07515 ENOG41069ER domain protein BTXL6_07530 ENOG4105CEP NADH dehydrogenase BTXL6_07555 ENOG4105EWC Purine nucleoside phosphorylase BTXL6_07575 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BTXL6_07600 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BTXL6_07605 ENOG4105C4B ABC transporter, permease BTXL6_07610 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BTXL6_07635 ENOG41083MR nifu domain-containing protein BTXL6_07650 ENOG4108W5N phosphatidylglycerophosphatase a BTXL6_07665 ENOG4105DYS nad(p)h dehydrogenase (quinone) BTXL6_07670 ENOG4105D4U had-superfamily hydrolase, subfamily iia BTXL6_07685 ENOG4105CBT Fructose-1,6-bisphosphatase BTXL6_07705 ENOG4105MMD transcriptional regulator BTXL6_07710 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BTXL6_07715 ENOG4107TXC Transcriptional regulator BTXL6_07720 ENOG41090T1 Membrane BTXL6_07745 ENOG4105FAA peptidase M23 BTXL6_07755 ENOG4105KZD Domain of unknown function (DUF1805) BTXL6_07760 ENOG4107R8B 5'-nucleotidase BTXL6_07775 ENOG4105DIW FeS assembly protein SUFB BTXL6_07780 ENOG4108UNV SUF system FeS assembly protein, NifU family BTXL6_07785 ENOG4105C9B Cysteine desulfurase BTXL6_07790 ENOG4105JRK feS assembly protein SufD BTXL6_07795 ENOG4105C3K feS assembly ATPase SufC BTXL6_07800 ENOG4105D01 (LipO)protein BTXL6_07805 ENOG4105D01 (LipO)protein BTXL6_07810 ENOG4108UMI ABC transporter, permease BTXL6_07840 ENOG41080E8 Transcriptional regulator, Spx MgsR family BTXL6_07910 ENOG4108W8B Beta-lactamase domain protein BTXL6_07915 ENOG4105C1G acyl-Coa dehydrogenase BTXL6_07920 ENOG4105CHU acetyl-coa acetyltransferase BTXL6_07935 ENOG4105DZ1 carboxypeptidase BTXL6_07955 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTXL6_07975 ENOG4108SUT Major Facilitator Superfamily BTXL6_07980 ENOG4107R7I amino acid BTXL6_07995 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BTXL6_08005 ENOG4107AYK membrAne BTXL6_08040 ENOG4107ZTW SNARE associated Golgi BTXL6_08050 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTXL6_08055 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_08060 ENOG4105BZU Histidine kinase BTXL6_08080 ENOG4105C8Q Methyl-accepting chemotaxis BTXL6_08085 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTXL6_08090 ENOG4105VG1 fes assembly suf system protein BTXL6_08095 ENOG4105D4Y metalloprotease BTXL6_08115 ENOG4107T5V SNARE associated Golgi BTXL6_08120 ENOG4107S91 Sodium hydrogen exchanger BTXL6_08125 ENOG4105NCW Trka-c domain protein BTXL6_08140 ENOG4108RMU ferritin dps family protein BTXL6_08155 ENOG4108URH decarboxylase BTXL6_08175 ENOG4105D9N nucleoside BTXL6_08180 ENOG4105D9N nucleoside BTXL6_08195 ENOG4108RYK Nad-dependent epimerase dehydratase BTXL6_08210 ENOG4105CV8 reductase BTXL6_08215 ENOG4105F27 Major Facilitator BTXL6_08220 ENOG4105KVH Transcriptional regulator BTXL6_08235 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BTXL6_08240 ENOG4105D4A Cell wall formation (By similarity) BTXL6_08250 ENOG4105C8Q Methyl-accepting chemotaxis BTXL6_08260 ENOG4105WMR Protein CrcB homolog BTXL6_08280 ENOG4108MK9 spermidine N(1)-acetyltransferase BTXL6_08285 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BTXL6_08320 ENOG4108IPW abc transporter atp-binding protein BTXL6_08325 ENOG4105CM4 permease protein BTXL6_08345 ENOG4105EWM Histidine kinase BTXL6_08350 ENOG4105CJZ response regulator BTXL6_08355 ENOG4105C19 ABC transporter BTXL6_08375 ENOG4105C19 ABC transporter BTXL6_08400 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BTXL6_08410 ENOG4105XZU Preprotein translocase, subunit SecG BTXL6_08415 ENOG41067MG lrgb family BTXL6_08435 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BTXL6_08465 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTXL6_08485 ENOG41090VF Stage v sporulation protein ac BTXL6_08490 ENOG4105CZ3 stage V sporulation protein ad BTXL6_08505 ENOG4108QY0 Membrane BTXL6_08510 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTXL6_08515 ENOG4105KRI phosphocarrier protein (HPr BTXL6_08525 ENOG4105CHW UPF0052 protein BTXL6_08535 ENOG4108Z4K mutator MutT protein BTXL6_08545 ENOG4105C3M thioredoxin reductase BTXL6_08555 ENOG4108S4C acetyltransferase BTXL6_08575 ENOG41086DT Membrane protein of unknown function BTXL6_08585 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BTXL6_08590 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BTXL6_08605 ENOG4107TXC Transcriptional regulator BTXL6_08625 ENOG4105DUM transcriptional regulator, lysR family BTXL6_08635 ENOG4108WS4 fmn reductase BTXL6_08650 ENOG4105BZ1 (ABC) transporter BTXL6_08660 ENOG4105CN1 protease BTXL6_08665 ENOG4105CRP Part of the ABC transporter FtsEX involved in BTXL6_08670 ENOG4105CAK Cell division ATP-binding protein ftsE BTXL6_08680 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BTXL6_08690 ENOG4105MS2 ribosomal subunit Interface protein BTXL6_08695 ENOG4105VEQ Cold shock protein BTXL6_08700 ENOG41081UC Inherit from COG: Competence protein BTXL6_08715 ENOG4105KVH Transcriptional regulator BTXL6_08730 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BTXL6_08735 ENOG4108KGH TRANSCRIPTIONal BTXL6_08740 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BTXL6_08745 ENOG4105C6Y Udp-glucose 6-dehydrogenase BTXL6_08750 ENOG4105ESV Glycosyl transferase, family 4 BTXL6_08760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BTXL6_08780 ENOG4105F8D glycoside hydrolase family 4 BTXL6_08785 ENOG4105VCP PTS System BTXL6_08790 ENOG4105CK1 PTS System BTXL6_08800 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BTXL6_08810 ENOG4105VCP PTS System BTXL6_08820 ENOG4105VZJ PTS System BTXL6_08835 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BTXL6_08840 ENOG4105ECB domain protein BTXL6_08845 ENOG4107RSM transcriptional regulator BTXL6_08885 ENOG4105DAA L-lactate BTXL6_08895 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) BTXL6_08905 ENOG4105E0M Sulfatase BTXL6_08930 ENOG4107R8N Glycosyl transferase, family 2 BTXL6_08940 ENOG4105C94 Transporter BTXL6_08945 ENOG41069ER domain protein BTXL6_08970 ENOG4105KBK Zinc finger, swim domain protein BTXL6_08975 ENOG4105C0D helicase BTXL6_09005 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTXL6_09015 ENOG4107RBB ABC transporter, permease BTXL6_09020 ENOG4105C19 ABC transporter BTXL6_09030 ENOG4105CXY transporter BTXL6_09045 ENOG4105BZU Histidine kinase BTXL6_09050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_09055 ENOG4105CMR udp-glucose 4-epimerase BTXL6_09080 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BTXL6_09085 ENOG4105EY8 ABC transporter BTXL6_09095 ENOG4107SJB teichoic acid biosynthesis BTXL6_09105 ENOG4105CG5 Glycosyl transferase (Group 1 BTXL6_09110 ENOG4107SJB teichoic acid biosynthesis BTXL6_09115 ENOG4107RZX Teichoic acid biosynthesis protein BTXL6_09120 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BTXL6_09130 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BTXL6_09140 ENOG4105FRN stage II sporulation protein BTXL6_09155 ENOG4105DY9 regulatoR BTXL6_09175 ENOG4106778 Protein of unknown function (DUF1146) BTXL6_09180 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTXL6_09185 ENOG4105C8S subunit m BTXL6_09190 ENOG4105D65 subunit l BTXL6_09215 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BTXL6_09220 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTXL6_09230 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BTXL6_09235 ENOG4105BZU Histidine kinase BTXL6_09285 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BTXL6_09290 ENOG41062M3 atp synthase BTXL6_09320 ENOG4108YZG isomerase BTXL6_09335 ENOG4108VGI doxx family BTXL6_09340 ENOG4107XC4 flavin reductase domain protein, FMN-binding BTXL6_09355 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BTXL6_09365 ENOG4108ZXQ stage ii sporulation protein r BTXL6_09370 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BTXL6_09375 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BTXL6_09390 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BTXL6_09395 ENOG4105CBT Fructose-1,6-bisphosphatase BTXL6_09400 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BTXL6_09435 ENOG4105C1G acyl-Coa dehydrogenase BTXL6_09440 ENOG4105C1G acyl-Coa dehydrogenase BTXL6_09445 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BTXL6_09455 ENOG4105DF6 Fe-S oxidoreductase BTXL6_09470 ENOG4105BZU Histidine kinase BTXL6_09495 ENOG4105BZU Histidine kinase BTXL6_09500 ENOG4105KCT ABC transporter BTXL6_09505 ENOG4108M15 ABC transporter BTXL6_09510 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BTXL6_09515 ENOG4105IIU Aminopeptidase BTXL6_09545 ENOG4105EMN RNA polymerase sigma factor BTXL6_09555 ENOG410684U Domain of unknown function (DUF1934) BTXL6_09580 ENOG4105CYW agmatinase BTXL6_09590 ENOG4105DXB Major Facilitator superfamily BTXL6_09620 ENOG4105FA2 dna polymerase iii BTXL6_09630 ENOG4105EKQ RNA-directed DNA polymerase BTXL6_09665 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BTXL6_09705 ENOG4107JM4 Tetratricopeptide repeat BTXL6_09780 ENOG4105KRN Transcriptional regulator, abrb family BTXL6_09785 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BTXL6_09790 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTXL6_09860 ENOG4105TQK DNA polymerase iii, delta' subunit BTXL6_09970 ENOG4105C3F Signal peptidase i BTXL6_10000 ENOG4105C6E dna polymerase iii BTXL6_10030 ENOG4105WH1 Two component transcriptional regulator luxr family BTXL6_10035 ENOG4105BZU Histidine kinase BTXL6_10235 ENOG4105CDU Replicative dna helicase BTXL6_10365 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTXL6_10530 ENOG4105BZU Histidine kinase BTXL6_10550 ENOG410625E BTXL6_10555 ENOG4106A3M Cytochrome p-450 BTXL6_10675 ENOG4105E1K spore germination protein BTXL6_10730 ENOG4106F1P AAA ATPase, central domain protein BTXL6_10735 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BTXL6_10845 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BTXL6_10890 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTXL6_10960 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTXL6_10975 ENOG4107Y9E nuclease BTXL6_11020 ENOG4105FA0 parb-like partition protein BTXL6_11115 ENOG4105DQ6 Transposase BTXL6_11185 ENOG4105D13 transposase BTXL6_11275 ENOG4105DQ6 Transposase BTXL6_11340 ENOG4105DQ6 Transposase BTXL6_11385 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTXL6_11405 ENOG4108SHN Glycosyl transferase, family 2 BTXL6_11425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTXL6_11450 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BTXL6_11455 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BTXL6_11460 ENOG4105C83 adenylosuccinate lyase BTXL6_11470 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BTXL6_11495 ENOG4108V3E phosphoribosylglycinamide formyltransferase BTXL6_11505 ENOG4105C12 Phosphoribosylglycinamide synthetase BTXL6_11535 ENOG4105C4R Atp-dependent dna helicase BTXL6_11565 ENOG4108W2Y isochorismatase BTXL6_11575 ENOG4108UMI ABC transporter, permease BTXL6_11580 ENOG4105D01 (LipO)protein BTXL6_11600 ENOG410834F Transcriptional regulator BTXL6_11605 ENOG4107I77 yiaA/B two helix domain BTXL6_11625 ENOG4105CBD Diacylglycerol kinase BTXL6_11630 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BTXL6_11635 ENOG4108JPW Aminotransferase BTXL6_11645 ENOG4105C26 Dehydrogenase BTXL6_11650 ENOG4105KPY Small multidrug resistance protein BTXL6_11670 ENOG4105D9N nucleoside BTXL6_11675 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BTXL6_11685 ENOG4105BZU Histidine kinase BTXL6_11690 ENOG4108W15 Protein of unknown function (DUF1456) BTXL6_11705 ENOG4105DTQ mandelate racemase muconate lactonizing BTXL6_11715 ENOG4105DFD Na H antiporter BTXL6_11735 ENOG4105D3R alkyl hydroperoxide reductase BTXL6_11740 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BTXL6_11745 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BTXL6_11750 ENOG4107W7X Aldolase BTXL6_11755 ENOG4105EHG Permease protein BTXL6_11760 ENOG4105DQ5 transport system permease protein BTXL6_11765 ENOG4108V5C ABC transporter BTXL6_11790 ENOG4106UIA BTXL6_11795 ENOG4106UIA BTXL6_11830 ENOG410756H nucleotidyltransferase BTXL6_11835 ENOG4105D2S major facilitator superfamily BTXL6_11850 ENOG4105E5Q amino acid AbC transporter BTXL6_11855 ENOG4105EAB amino acid AbC transporter BTXL6_11865 ENOG4105C8Q Methyl-accepting chemotaxis BTXL6_11880 ENOG4105DBV ornithine carbamoyltransferase BTXL6_11890 ENOG4105C5B carbamate kinase BTXL6_11895 ENOG4108W63 CRP FNR family transcriptional regulator BTXL6_11905 ENOG4105DNP FAD linked oxidase domain protein BTXL6_11915 ENOG4105CI1 PTS System BTXL6_11945 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BTXL6_11960 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTXL6_11980 ENOG4105C5H ABC transporter BTXL6_12010 ENOG41062JF Transcriptional regulator BTXL6_12025 ENOG4105DEU major facilitator superfamily BTXL6_12055 ENOG4108N0M stress protein BTXL6_12060 ENOG4106FN3 tellurium resistance protein BTXL6_12065 ENOG4106FN3 tellurium resistance protein BTXL6_12070 ENOG4107TS3 membrane protein, TerC BTXL6_12075 ENOG4108TTB tellurium resistance protein BTXL6_12095 ENOG4105KJF protein tyrosine phosphatase BTXL6_12105 ENOG4107U9T Pfam:Ribonuclease_BN BTXL6_12110 ENOG4105C59 p-type ATPase BTXL6_12115 ENOG4108IPJ Membrane BTXL6_12135 ENOG4107ZTW SNARE associated Golgi BTXL6_12150 ENOG410606W general stress protein BTXL6_12155 ENOG4105UPD Calcium Proton BTXL6_12205 ENOG4108JUB Transcriptional regulator BTXL6_12215 ENOG4108IQI permease BTXL6_12250 ENOG4105CSV Glutaminase BTXL6_12260 ENOG4108A04 Beta-lactamase BTXL6_12280 ENOG4105CKK Glycosyl transferase, family 2 BTXL6_12285 ENOG4107QQG Dehydrogenase BTXL6_12290 ENOG4105C3I Nad-dependent epimerase dehydratase BTXL6_12305 ENOG4105F1A Pyruvate formate-lyase BTXL6_12325 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BTXL6_12330 ENOG4105ECP epimerase BTXL6_12360 ENOG41067AE Membrane-bound metal-dependent hydrolase BTXL6_12365 ENOG4105CEN a g-specific adenine glycosylase BTXL6_12370 ENOG4106BXE BTXL6_12390 ENOG4105BZ1 (ABC) transporter BTXL6_12395 ENOG4107NBY Membrane BTXL6_12400 ENOG4105CBC glutamate synthase BTXL6_12410 ENOG4108IUW ABC transporter BTXL6_12430 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BTXL6_12435 ENOG4105G5W regulator Fur family BTXL6_12550 ENOG4108JQC penicillin-binding protein 1A BTXL6_12555 ENOG4107ZQN disulfide bond BTXL6_12570 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BTXL6_12580 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BTXL6_12585 ENOG4105BZU Histidine kinase BTXL6_12595 ENOG4105CYN Serine protein kinase BTXL6_12620 ENOG4105C94 Transporter BTXL6_12635 ENOG4105DZ6 Band 7 protein BTXL6_12645 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BTXL6_12650 ENOG4108V9W transcriptional regulatory protein BTXL6_12655 ENOG4105D4T Citrate transporter BTXL6_12680 ENOG4108STX response regulator BTXL6_12685 ENOG4105US7 Histidine kinase BTXL6_12710 ENOG4108MRH transcriptional regulatory protein BTXL6_12720 ENOG4105C6K Malic enzyme BTXL6_12730 ENOG4108UZ3 Transporter BTXL6_12735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTXL6_12745 ENOG4105BZU Histidine kinase BTXL6_12750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_12760 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BTXL6_12765 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BTXL6_12770 ENOG4108JB9 formate dehydrogenase BTXL6_12790 ENOG4105CUB amino acid BTXL6_12800 ENOG4105C59 p-type ATPase BTXL6_12805 ENOG4105DAP Nicotinate phosphoribosyltransferase BTXL6_12835 ENOG41073R8 VanW family BTXL6_12840 ENOG4108KGH TRANSCRIPTIONal BTXL6_12845 ENOG4105D9N nucleoside BTXL6_12850 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BTXL6_12855 ENOG4105C37 (CBS) domain BTXL6_12860 ENOG4108IJ0 Aspartate ammonia-lyase BTXL6_12865 ENOG4105DAA L-lactate BTXL6_12880 ENOG4105DUX Transporter BTXL6_12885 ENOG4108MES Periplasmic binding protein BTXL6_12890 ENOG4105DQ5 transport system permease protein BTXL6_12895 ENOG4108IHU transport system permease protein BTXL6_12900 ENOG4105E0A ABC, transporter BTXL6_12905 ENOG4105DMQ Methyltransferase BTXL6_12915 ENOG4105EXW epimerase dehydratase BTXL6_12920 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BTXL6_12930 ENOG4107T89 von Willebrand factor, type A BTXL6_12935 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BTXL6_12940 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTXL6_12955 ENOG4105BZU Histidine kinase BTXL6_12960 ENOG4105D5Q Arginine ornithine antiporter BTXL6_12965 ENOG4107414 GntR family transcriptional regulator BTXL6_12970 ENOG4105C5Y PTS System BTXL6_12975 ENOG4105CG3 alpha amylase, catalytic region BTXL6_12990 ENOG4105E1K spore germination protein BTXL6_12995 ENOG4105CRN Aminoglycoside phosphotransferase BTXL6_13000 ENOG4105BZG amino acid carrier protein BTXL6_13005 ENOG4105CDA abc transporter atp-binding protein BTXL6_13010 ENOG4105CT1 (ABC) transporter BTXL6_13015 ENOG4105EAD ABC transporter BTXL6_13020 ENOG4105DRP amino acid AbC transporter BTXL6_13025 ENOG4108IQI permease BTXL6_13040 ENOG4105GFR rna polymerase sigma factor BTXL6_13050 ENOG4105D29 Helix-turn-helix type 11 domain protein BTXL6_13055 ENOG4105NAE bifunctional deaminase-reductase domain protein BTXL6_13060 ENOG4105BZU Histidine kinase BTXL6_13075 ENOG4105CHH sulfate transporter BTXL6_13080 ENOG41068KF Universal stress protein BTXL6_13100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTXL6_13105 ENOG4108JQ7 (ABC) transporter BTXL6_13115 ENOG4105CXY transporter BTXL6_13120 ENOG41067TZ transcriptional regulator, MarR family BTXL6_13125 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTXL6_13130 ENOG4105ETE Transcriptional regulator (LacI family BTXL6_13135 ENOG4108RVA ribokinase BTXL6_13145 ENOG4105C2J ABC transporter BTXL6_13150 ENOG4105CNN ABC, transporter BTXL6_13155 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BTXL6_13160 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BTXL6_13215 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BTXL6_13220 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BTXL6_13225 ENOG41069ER domain protein BTXL6_13230 ENOG4105VZ8 Transcriptional regulator BTXL6_13235 ENOG4107D63 BTXL6_13245 ENOG4105DUX Transporter BTXL6_13265 ENOG4105C85 amino acid BTXL6_13270 ENOG4105C7N Xanthine uracil vitamin C permease BTXL6_13285 ENOG4105MA6 gCN5-related N-acetyltransferase BTXL6_13310 ENOG4105BZ9 Cytochrome C oxidase, subunit I BTXL6_13315 ENOG4105E2S oxidase) subunit II BTXL6_13335 ENOG4106CAD Protein of unknown function (DUF3311) BTXL6_13340 ENOG4105E1V na solute symporter BTXL6_13355 ENOG4108NHD germination protein BTXL6_13365 ENOG4105CE1 Ferrous iron transport protein b BTXL6_13370 ENOG4105CE1 Ferrous iron transport protein b BTXL6_13375 ENOG4105CE1 Ferrous iron transport protein b BTXL6_13380 ENOG4105CVA phosphate BTXL6_13385 ENOG4105C8U phosphate abc transporter BTXL6_13390 ENOG4105E2Z phosphate ABC transporter (Permease BTXL6_13520 ENOG41080XQ Signal transduction protein with cbs domains BTXL6_13545 ENOG4105ETU transcriptional activator (TenA BTXL6_13555 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BTXL6_13565 ENOG4108VEU Thiamine monophosphate synthase BTXL6_13570 ENOG41080HI glycine oxidase BTXL6_13585 ENOG4105D06 uba thif-type nad fad binding protein BTXL6_13590 ENOG4105DWF phosphomethylpyrimidine kinase BTXL6_13640 ENOG4108INS Transcriptional regulator BTXL6_13655 ENOG4105C7N Xanthine uracil vitamin C permease BTXL6_13665 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BTXL6_13700 ENOG4108B31 Spore germination protein BTXL6_13720 ENOG4107Y03 Nitroreductase BTXL6_13725 ENOG4105ED1 spovr family BTXL6_13735 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BTXL6_13740 ENOG4105XTG Pfam:DUF156 BTXL6_13745 ENOG4105VFE sira family BTXL6_13750 ENOG4107TPS domain protein BTXL6_13755 ENOG4105VFE sira family BTXL6_13760 ENOG4105VFE sira family BTXL6_13770 ENOG4105VFE sira family BTXL6_13780 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BTXL6_13785 ENOG41087NI Sulfite exporter TauE/SafE BTXL6_13795 ENOG4108KGH TRANSCRIPTIONal BTXL6_13820 ENOG4105EMD TRANSCRIPTIONal BTXL6_13825 ENOG4105VCP PTS System BTXL6_13830 ENOG4105VZJ PTS System BTXL6_13855 ENOG41069ER domain protein BTXL6_13860 ENOG4107RBB ABC transporter, permease BTXL6_13865 ENOG4105C19 ABC transporter BTXL6_13870 ENOG4108WMK Efflux transporter RND family MFP subunit BTXL6_13895 ENOG4105WEF catalase BTXL6_13930 ENOG4107T5V SNARE associated Golgi BTXL6_13965 ENOG4105CUB amino acid BTXL6_13970 ENOG4107RWR Sodium hydrogen exchanger BTXL6_13980 ENOG4106KNT transcriptional regulator BTXL6_14020 ENOG4108YXU transcriptional regulator AsnC family BTXL6_14030 ENOG4108IXY short-chain dehydrogenase reductase BTXL6_14040 ENOG4105KPY Small multidrug resistance protein BTXL6_14045 ENOG4105KPY Small multidrug resistance protein BTXL6_14070 ENOG4105NF4 modulator of drug activity BTXL6_14075 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BTXL6_14080 ENOG4105E5W Transporter BTXL6_14090 ENOG4107RKG DJ-1/PfpI family BTXL6_14095 ENOG4105CH6 catalase BTXL6_14105 ENOG4105D5Q Arginine ornithine antiporter BTXL6_14110 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BTXL6_14120 ENOG4105C26 Dehydrogenase BTXL6_14130 ENOG4105BZ1 (ABC) transporter BTXL6_14135 ENOG4105BZ1 (ABC) transporter BTXL6_14145 ENOG4105DRP amino acid AbC transporter BTXL6_14150 ENOG4105CDA abc transporter atp-binding protein BTXL6_14165 ENOG410839P BTXL6_14200 ENOG4107FQX Alpha-acetolactate decarboxylase BTXL6_14225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTXL6_14230 ENOG4105D4P Coproporphyrinogen iii oxidase BTXL6_14250 ENOG4105CHH sulfate transporter BTXL6_14285 ENOG4106AKK s-layer domain-containing protein BTXL6_14295 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BTXL6_14305 ENOG4105CGU Enoyl-CoA hydratase BTXL6_14325 ENOG4105DER m42 family BTXL6_14345 ENOG4105CTU Proline racemase BTXL6_14380 ENOG4105CDU Replicative dna helicase BTXL6_14425 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTXL6_14450 ENOG4105ESF Peptidoglycan binding domain protein BTXL6_14465 ENOG4105CSH Transporter BTXL6_14475 ENOG4108MRH transcriptional regulatory protein BTXL6_14485 ENOG4105M6F mutator MutT protein BTXL6_14520 ENOG4105DZR Type I site-specific deoxyribonuclease BTXL6_14540 ENOG4105CDU Replicative dna helicase BTXL6_14580 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTXL6_14660 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTXL6_14680 ENOG4105CMT Dihydroxyacetone kinase BTXL6_14700 ENOG410847I Transcriptional regulator, BadM Rrf2 family BTXL6_14725 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BTXL6_14785 ENOG4108WC5 Alpha Beta Hydrolase Fold protein BTXL6_14820 ENOG4105WN5 stage II sporulation protein BTXL6_14830 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BTXL6_14840 ENOG4108MJI response regulator BTXL6_14845 ENOG4105BZU Histidine kinase BTXL6_14850 ENOG4105BZU Histidine kinase BTXL6_14875 ENOG4105K8R UPF0145 protein BTXL6_14920 ENOG4107VRP DNA repair exonuclease BTXL6_14925 ENOG4106D4I domain protein BTXL6_14935 ENOG4108IND Tetr family transcriptional regulator BTXL6_14940 ENOG4105EQ0 Major Facilitator superfamily BTXL6_14960 ENOG4108MUZ hydrolase BTXL6_14980 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BTXL6_14995 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BTXL6_15010 ENOG4105EMN RNA polymerase sigma factor BTXL6_15020 ENOG4105CNI cell division protein FtsW BTXL6_15030 ENOG4105EEM helicase BTXL6_15035 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTXL6_15065 ENOG4105K59 histidine triad (HIT) protein BTXL6_15095 ENOG410905X membrane-flanked domain protein BTXL6_15100 ENOG4105CKV Membrane BTXL6_15140 ENOG410905X membrane-flanked domain protein BTXL6_15145 ENOG4105CKV Membrane BTXL6_15150 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BTXL6_15155 ENOG4105BZ4 penicillin-binding protein BTXL6_15170 ENOG4105C1Q protoporphyrinogen oxidase BTXL6_15200 ENOG4105ECB domain protein BTXL6_15225 ENOG4105D29 Helix-turn-helix type 11 domain protein BTXL6_15235 ENOG4106AXD BTXL6_15240 ENOG4108RQ5 Beta-lactamase domain-containing protein BTXL6_15245 ENOG4105DF9 Lipoate-protein, ligase BTXL6_15255 ENOG4105CEY Amp-dependent synthetase and ligase BTXL6_15270 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) BTXL6_15280 ENOG4105ENX hydrolase BTXL6_15285 ENOG4107RN3 metallophosphoesterase BTXL6_15290 ENOG4107TVP HD domain protein BTXL6_15300 ENOG4105C57 major facilitator superfamily BTXL6_15310 ENOG4108AEY RNA polymerase sigma factor BTXL6_15315 ENOG41086D8 Transcriptional regulator BTXL6_15335 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTXL6_15360 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BTXL6_15365 ENOG4105C8Q Methyl-accepting chemotaxis BTXL6_15385 ENOG4105ZU5 s-layer protein BTXL6_15390 ENOG4107QP3 malate synthase g BTXL6_15405 ENOG4105VEQ Cold shock protein BTXL6_15420 ENOG4105XVF Competence transcription factor BTXL6_15490 ENOG4105ERH Fumarylacetoacetate hydrolase BTXL6_15515 ENOG4105CAQ asparagine synthetase BTXL6_15525 ENOG4105CH6 catalase BTXL6_15530 ENOG4105BZU Histidine kinase BTXL6_15545 ENOG4107A6P BTXL6_15560 ENOG4108VPT UPF0234 protein BTXL6_15565 ENOG4105QNR S1 RNA binding domain protein BTXL6_15570 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTXL6_15580 ENOG4107AYK membrAne BTXL6_15585 ENOG41073B9 BTXL6_15595 ENOG4108KP7 hydrolase BTXL6_15610 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BTXL6_15635 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BTXL6_15640 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BTXL6_15655 ENOG4105C31 Tryptophanyl-tRNA synthetase BTXL6_15670 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BTXL6_15675 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BTXL6_15685 ENOG4108JQ7 (ABC) transporter BTXL6_15690 ENOG4105UQX Mate efflux family protein BTXL6_15715 ENOG4108ZCF integral membrane protein BTXL6_15725 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTXL6_15735 ENOG4105DPN Oligoendopeptidase f BTXL6_15750 ENOG4108Z18 K06886 hemoglobin BTXL6_15755 ENOG4105MIX Adenylate cyclase BTXL6_15760 ENOG4106EFP UPF0738 protein BTXL6_15775 ENOG4105EMS pseudouridine synthase BTXL6_15795 ENOG4105K64 Glycosyl transferase, family 2 BTXL6_15815 ENOG4107TVC Glycosyl transferase, family 2 BTXL6_15835 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BTXL6_15840 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BTXL6_15850 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BTXL6_15895 ENOG4105EKQ RNA-directed DNA polymerase BTXL6_15935 ENOG4105CK7 Sodium proline symporter BTXL6_15945 ENOG4105CRQ synthase (Component I) BTXL6_15950 ENOG4105DDQ anthranilate synthase BTXL6_15970 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BTXL6_16050 ENOG4105C7S Dehydrogenase BTXL6_16060 ENOG4105VZ8 Transcriptional regulator BTXL6_16130 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BTXL6_16140 ENOG4105DZ1 carboxypeptidase BTXL6_16145 ENOG4105VFR signal peptidase BTXL6_16180 ENOG4105C26 Dehydrogenase BTXL6_16190 ENOG4105F38 ABC transporter, permease BTXL6_16195 ENOG4105D38 putrescine abc transporter BTXL6_16200 ENOG4107RUE extracellular solute-binding protein family 1 BTXL6_16210 ENOG4105EYF MMPL domain protein BTXL6_16220 ENOG4108YBP pseudouridine synthase BTXL6_16230 ENOG4105K4I Scp-like extracellular BTXL6_16235 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BTXL6_16240 ENOG4105CQB FAD linked oxidase domain protein BTXL6_16255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_16260 ENOG4105BZU Histidine kinase BTXL6_16265 ENOG4105JXH GntR family transcriptional regulator BTXL6_16285 ENOG4106A3R peptidase BTXL6_16295 ENOG4108QTI )-transporter BTXL6_16300 ENOG4107TS3 membrane protein, TerC BTXL6_16305 ENOG4105CZN Potassium uptake protein BTXL6_16310 ENOG410681C small acid-soluble spore protein BTXL6_16315 ENOG4108Z7G MaoC domain protein dehydratase BTXL6_16335 ENOG4105CHR reductase BTXL6_16365 ENOG4105C4Y ABC transporter BTXL6_16370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTXL6_16375 ENOG4107RCV ABC transporter, permease BTXL6_16395 ENOG4105E98 transcriptional regulator DeoR family BTXL6_16410 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BTXL6_16420 ENOG4105PXI polysaccharide deacetylase BTXL6_16430 ENOG4105BZU Histidine kinase BTXL6_16435 ENOG41090MY MarR family Transcriptional regulator BTXL6_16445 ENOG4106DF1 BTXL6_16455 ENOG4105BZU Histidine kinase BTXL6_16465 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BTXL6_16470 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BTXL6_16515 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BTXL6_16530 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BTXL6_16535 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BTXL6_16540 ENOG4105CZV ABC transporter BTXL6_16550 ENOG4105CJ1 ABC, transporter BTXL6_16590 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BTXL6_16595 ENOG4105EA8 2-Nitropropane dioxygenase BTXL6_16600 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTXL6_16610 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BTXL6_16635 ENOG4105NQC Flavodoxin BTXL6_16670 ENOG4107QMU Mate efflux family protein BTXL6_16705 ENOG4105CZN Potassium uptake protein BTXL6_16710 ENOG41063Y9 BTXL6_16715 ENOG4105KBJ sporulation protein ytfj BTXL6_16745 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTXL6_16750 ENOG4105C7K acetolactate synthase BTXL6_16755 ENOG4108ZP8 Acetolactate synthase small subunit BTXL6_16830 ENOG4107RVV histidinol phosphate phosphatase, hisj family BTXL6_16845 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BTXL6_16850 ENOG4105E0M Sulfatase BTXL6_16860 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BTXL6_16880 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BTXL6_16885 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BTXL6_16895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTXL6_16900 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTXL6_16905 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTXL6_16915 ENOG4105C8J )-transporter BTXL6_16935 ENOG4105DFD Na H antiporter BTXL6_16955 ENOG4105ENE Histidine kinase BTXL6_16960 ENOG4105WH1 Two component transcriptional regulator luxr family BTXL6_16980 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTXL6_17030 ENOG4105CJ3 phosphate transporter BTXL6_17035 ENOG4107GRR phosphate transport regulator BTXL6_17040 ENOG4105BZ4 penicillin-binding protein BTXL6_17055 ENOG4105BZU Histidine kinase BTXL6_17060 ENOG4105I3N Conserved Protein BTXL6_17075 ENOG4105BZU Histidine kinase BTXL6_17080 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BTXL6_17105 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BTXL6_17110 ENOG4105DZ1 carboxypeptidase BTXL6_17115 ENOG4108JIC nucleoside recognition domain protein BTXL6_17125 ENOG4105FE9 pseudouridine synthase BTXL6_17135 ENOG4107TWT Cytochrome c biogenesis protein BTXL6_17140 ENOG4105CRE cytochrome C BTXL6_17145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_17150 ENOG4105BZU Histidine kinase BTXL6_17155 ENOG4108WBT adenosyltransferase BTXL6_17160 ENOG41063SB peptidase BTXL6_17170 ENOG4108SAX Membrane BTXL6_17185 ENOG4105C9U ATP-dependent DNA helicase RecQ BTXL6_17190 ENOG4105I7S Abortive infection protein BTXL6_17200 ENOG4107RGJ metallophosphoesterase BTXL6_17205 ENOG4107X2D transcriptional regulator, merr family BTXL6_17210 ENOG4108S6Z Negative regulator of genetic competence BTXL6_17235 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BTXL6_17240 ENOG4107RB3 L-asparaginase BTXL6_17275 ENOG4105S2F BTXL6_17280 ENOG41065D1 BTXL6_17310 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BTXL6_17325 ENOG4105XXQ heptaprenyl diphosphate synthase component I BTXL6_17335 ENOG4105EAH synthase BTXL6_17360 ENOG41068YB TPR repeat-containing protein BTXL6_17375 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BTXL6_17380 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BTXL6_17415 ENOG4108JYZ YitT family BTXL6_17420 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BTXL6_17435 ENOG4105FJR Lmbe family BTXL6_17440 ENOG4105CPK Glycosyl transferase (Group 1 BTXL6_17475 ENOG4105DVT helicase BTXL6_17480 ENOG4105YAC BTXL6_17500 ENOG4105CSM endonuclease III BTXL6_17510 ENOG4105BZ4 penicillin-binding protein BTXL6_17560 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BTXL6_17570 ENOG4105DVT helicase BTXL6_17575 ENOG4105CTD carboxy-peptidase BTXL6_17585 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BTXL6_17590 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BTXL6_17595 ENOG4105C2W permease BTXL6_17600 ENOG4105DHF Membrane BTXL6_17605 ENOG410890F Dynamin family BTXL6_17615 ENOG4108W0I acetyltransferase BTXL6_17625 ENOG4105KHC sulfurtransferase BTXL6_17640 ENOG4106032 Glutathionylspermidine synthase BTXL6_17665 ENOG4105EXC Acyl-transferase BTXL6_17700 ENOG4105CPK Glycosyl transferase (Group 1 BTXL6_17715 ENOG4108SZE gCN5-related N-acetyltransferase BTXL6_17735 ENOG41081VK Ribonuclease BTXL6_17800 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTXL6_17810 ENOG4107RWR Sodium hydrogen exchanger BTXL6_17815 ENOG4105CN5 Metallo-Beta-Lactamase BTXL6_17820 ENOG4108Z5V transcriptional regulator, merr family BTXL6_17830 ENOG4105H67 Protein of unknown function (DUF421) BTXL6_17835 ENOG41080C8 DUF218 domain BTXL6_17860 ENOG4107Y80 Major Facilitator superfamily BTXL6_17890 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTXL6_17900 ENOG4107R0U MotA TolQ exbB proton channel BTXL6_17905 ENOG4105ER2 Ompa motb domain protein BTXL6_17910 ENOG4107YTP response regulator receiver protein BTXL6_17915 ENOG4105CBS Chea signal transduction histidine kinase BTXL6_17920 ENOG4105DD5 Flagellar motor switch protein BTXL6_17935 ENOG4105BZU Histidine kinase BTXL6_17955 ENOG4105E1Q flagellar hook-associated protein BTXL6_17960 ENOG4105DTJ flagellar hook-associated protein BTXL6_17965 ENOG410804A Flagellar hook-associated 2 domain-containing protein BTXL6_17980 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BTXL6_17985 ENOG4108ZC9 flagellar basal-body rod protein flgc BTXL6_17990 ENOG41075Z6 flagellar hook-basal body complex protein fliE BTXL6_17995 ENOG4107U2N Flagellar M-ring protein BTXL6_18000 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTXL6_18030 ENOG4105BZE flagellar hook protein, FlgE BTXL6_18045 ENOG4107R88 Chemotaxis protein (CheV) BTXL6_18060 ENOG4105I03 Flagellin BTXL6_18065 ENOG4105E4C Lytic transglycosylase catalytic BTXL6_18075 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BTXL6_18080 ENOG4105DD5 Flagellar motor switch protein BTXL6_18090 ENOG4105CN7 Flagellar biosynthetic protein FliP BTXL6_18095 ENOG4105VS8 Flagellar biosynthetic protein fliq BTXL6_18105 ENOG4105D00 flagellar biosynthetic protein flhB BTXL6_18110 ENOG4105D7B Flagellar biosynthesis protein flha BTXL6_18115 ENOG4105FZW flagellar biosynthesis regulator FlhF BTXL6_18120 ENOG4105KTQ flagellar basal-body rod protein BTXL6_18125 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BTXL6_18150 ENOG41062JF Transcriptional regulator BTXL6_18170 ENOG4105KAC Antibiotic biosynthesis monooxygenase BTXL6_18190 ENOG4108U4N (sortase) family BTXL6_18220 ENOG4105DUM transcriptional regulator, lysR family BTXL6_18225 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BTXL6_18235 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component BTXL6_18240 ENOG4105CN5 Metallo-Beta-Lactamase BTXL6_18275 ENOG4105CVJ phosphoglycerate mutase BTXL6_18285 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BTXL6_18295 ENOG4105K56 Transcriptional regulator BTXL6_18305 ENOG4105CAQ asparagine synthetase BTXL6_18325 ENOG4105PGM cation diffusion facilitator family transporter BTXL6_18335 ENOG4105DRR Transcriptional regulator, GntR family BTXL6_18340 ENOG4108UZ3 Transporter BTXL6_18345 ENOG4105CKI cobalamin synthesis protein BTXL6_18350 ENOG4108PJD permease BTXL6_18365 ENOG4105DFD Na H antiporter BTXL6_18370 ENOG4105VUF Transcriptional regulator BTXL6_18375 ENOG4105EMU Dehydrogenase BTXL6_18380 ENOG4105C9Q fumarate hydratase class II BTXL6_18395 ENOG4105C5X domain protein BTXL6_18405 ENOG4107QJQ Mate efflux family protein BTXL6_18410 ENOG4105EC3 peptidase S51, dipeptidase E BTXL6_18450 ENOG4106BRA Membrane BTXL6_18485 ENOG4105CJ1 ABC, transporter BTXL6_18505 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BTXL6_18515 ENOG4108IJ0 Aspartate ammonia-lyase BTXL6_18520 ENOG4105C6K Malic enzyme BTXL6_18590 ENOG4105FVX BTXL6_18630 ENOG4105CSR polyphosphate kinase 2 BTXL6_18640 ENOG4105DXI Major Facilitator superfamily BTXL6_18655 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BTXL6_18665 ENOG4105EU0 Major facilitator Superfamily BTXL6_18670 ENOG4105C6T cysteine synthase BTXL6_18690 ENOG4105C8J )-transporter BTXL6_18700 ENOG4105X5K response regulator receiver protein BTXL6_18705 ENOG4105H67 Protein of unknown function (DUF421) BTXL6_18725 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BTXL6_18730 ENOG4105CM2 brancheD-chain amino acid aminotransferase BTXL6_18735 ENOG4105C7K acetolactate synthase BTXL6_18755 ENOG4105C7B Threonine dehydratase BTXL6_18780 ENOG4105C6X Major Facilitator BTXL6_18785 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BTXL6_18795 ENOG4105DY9 regulatoR BTXL6_18800 ENOG4105CYC Transferase BTXL6_18820 ENOG4105F6J Alpha beta hydrolase fold BTXL6_18840 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTXL6_18850 ENOG41068WN BTXL6_18870 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BTXL6_18885 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BTXL6_18895 ENOG4105C0X amino acid BTXL6_18935 ENOG4107RHR regulatoR BTXL6_18945 ENOG4105D9N nucleoside BTXL6_18950 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BTXL6_18975 ENOG4107RAQ aminopeptidase BTXL6_18980 ENOG4107R16 Multicopper oxidase BTXL6_19025 ENOG4108T5E Copper resistance protein BTXL6_19030 ENOG4105KTB nuclear export factor GLE1 BTXL6_19035 ENOG4107RT3 EamA-like transporter family BTXL6_19040 ENOG4105GZI Transcriptional regulator BTXL6_19045 ENOG4108Z40 Transcriptional regulator BTXL6_19050 ENOG4107ZXU DSBA oxidoreductase BTXL6_19055 ENOG4108TVJ Nitroreductase BTXL6_19070 ENOG4106F5Q Membrane BTXL6_19075 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BTXL6_19085 ENOG4105CKI cobalamin synthesis protein BTXL6_19100 ENOG4108Z7G MaoC domain protein dehydratase BTXL6_19105 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BTXL6_19120 ENOG4105C0Z ABC transporter BTXL6_19125 ENOG4108IV0 ABC, transporter BTXL6_19130 ENOG4105C32 Amino acid ABC transporter (Permease) BTXL6_19140 ENOG4105SKE transcriptional Regulator LysR family BTXL6_19150 ENOG4105MDS 4-oxalocrotonate tautomerase BTXL6_19170 ENOG4105C4M (Ubiquinol oxidase) subunit I BTXL6_19175 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BTXL6_19180 ENOG4108JJ9 ABC, transporter BTXL6_19185 ENOG4108JJ8 (ABC) transporter BTXL6_19195 ENOG4105K64 Glycosyl transferase, family 2 BTXL6_19205 ENOG4108UT6 Transferase hexapeptide repeat containing protein BTXL6_19250 ENOG4105BZ1 (ABC) transporter BTXL6_19255 ENOG4105EFI regulatoR BTXL6_19260 ENOG4105BZU Histidine kinase BTXL6_19280 ENOG41075D4 Aminoglycoside 6-adenylyltransferase BTXL6_19285 ENOG4108ZJ4 polysaccharide deacetylase BTXL6_19305 ENOG4105D6E homoserine dehydrogenase BTXL6_19330 ENOG4108KGH TRANSCRIPTIONal BTXL6_19340 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BTXL6_19345 ENOG4105BZU Histidine kinase BTXL6_19350 ENOG4107VMI polysaccharide deacetylase BTXL6_19360 ENOG4105KT7 mgtC SapB transporter BTXL6_19365 ENOG4105VRR gCN5-related N-acetyltransferase BTXL6_19375 ENOG4105DUU IucA IucC family protein BTXL6_19380 ENOG4105CEY Amp-dependent synthetase and ligase BTXL6_19395 ENOG4108WBH protein TIM barrel BTXL6_19400 ENOG4105YWU small acid-soluble spore protein BTXL6_19410 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BTXL6_19415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTXL6_19465 ENOG4105KRN Transcriptional regulator, abrb family BTXL6_19475 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BTXL6_19480 ENOG4105YVS arsR family transcriptional regulator BTXL6_19485 ENOG4105CPC Aldo Keto reductase BTXL6_19490 ENOG4107XZQ multidrug resistance protein BTXL6_19530 ENOG4108K88 Membrane BTXL6_19535 ENOG4108WPJ Ferritin-like domain BTXL6_19550 ENOG4105DEN Luciferase family BTXL6_19565 ENOG4105VMI -acetyltransferase BTXL6_19570 ENOG4107QM2 Aldo Keto reductase BTXL6_19575 ENOG4105CKI cobalamin synthesis protein BTXL6_19590 ENOG4108IBT Inherit from COG: transposase BTXL6_19595 ENOG4105DSE periplasmic solute binding protein BTXL6_19605 ENOG4105K4T epimerase BTXL6_19615 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BTXL6_19640 ENOG4105CVJ phosphoglycerate mutase BTXL6_19660 ENOG4107T5V SNARE associated Golgi BTXL6_19675 ENOG4108PJD permease BTXL6_19685 ENOG4108S4H thioesterase Superfamily protein BTXL6_19690 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BTXL6_19710 ENOG4105SXS Protein of unknown function (DUF456) BTXL6_19715 ENOG4105C37 (CBS) domain BTXL6_19735 ENOG4108Z7R Chaperone CsaA BTXL6_19755 ENOG4108ZRV stage ii sporulation protein p BTXL6_19765 ENOG4108VXD carboxy-peptidase BTXL6_19770 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTXL6_19775 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BTXL6_19800 ENOG4108X4Q Hydrolase BTXL6_19810 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BTXL6_19815 ENOG4107RBS Methyltransferase BTXL6_19830 ENOG41087PP glycosyltransferase MGT family BTXL6_19835 ENOG4108JYZ YitT family BTXL6_19840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BTXL6_19870 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BTXL6_19905 ENOG4105KBJ sporulation protein ytfj BTXL6_19930 ENOG4108KQJ Type 11 methyltransferase BTXL6_19950 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BTXL6_19960 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BTXL6_19965 ENOG4105EMN RNA polymerase sigma factor BTXL6_19995 ENOG4108V06 Glutathione peroxidase BTXL6_20010 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTXL6_20020 ENOG4108IUE nitrate reductase beta subunit BTXL6_20025 ENOG4105R3A Nitrate reductase BTXL6_20035 ENOG4107V6Q Cyclic nucleotide-binding domain BTXL6_20040 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BTXL6_20045 ENOG4105D06 uba thif-type nad fad binding protein BTXL6_20050 ENOG4105CVM Molybdenum cofactor synthesis domain protein BTXL6_20055 ENOG4108ZAF Molybdopterin BTXL6_20080 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BTXL6_20085 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BTXL6_20090 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BTXL6_20095 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BTXL6_20100 ENOG4108IFG nitrite reductase, (NAD(P)H) BTXL6_20105 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BTXL6_20130 ENOG4105MCT stage V sporulation protein S BTXL6_20145 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTXL6_20155 ENOG4107T65 Integrase BTXL6_20160 ENOG410635T phage-like element pbsx protein BTXL6_20170 ENOG4105M6F mutator MutT protein BTXL6_20220 ENOG4105CDU Replicative dna helicase BTXL6_20385 ENOG4105XSJ toxin secretion phage lysis holin BTXL6_20410 ENOG4105C5H ABC transporter BTXL6_20425 ENOG4108UUM single-stranded DNA-binding protein BTXL6_20445 ENOG4107YX5 Pfam:DUF548 BTXL6_20490 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BTXL6_20495 ENOG4105C5S asparaginyl-tRNA synthetase BTXL6_20515 ENOG4105EC2 ftsk spoIIIe BTXL6_20590 ENOG4105C8J )-transporter BTXL6_20610 ENOG4107XGZ Hydrolase BTXL6_20615 ENOG4105CY2 Citrate transporter BTXL6_20620 ENOG4105C0A alcohol dehydrogenase BTXL6_20635 ENOG4105KD7 acetyltransferase BTXL6_20640 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BTXL6_20665 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 BTXL6_20680 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) BTXL6_20700 ENOG4107RVG penicillin-binding protein BTXL6_20710 ENOG4105E9Q Acyl-transferase BTXL6_20715 ENOG4108UT2 hemolysin iii BTXL6_20725 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BTXL6_20735 ENOG4108RCR degv family BTXL6_20740 ENOG4105E8R UPF0173 metal-dependent hydrolase BTXL6_20745 ENOG4108KF3 Electron transport protein SCO1 SenC BTXL6_20750 ENOG4107Y70 Heat shock protein BTXL6_20755 ENOG4105CAQ asparagine synthetase BTXL6_20775 ENOG4108MES Periplasmic binding protein BTXL6_20780 ENOG4105F0I Aminotransferase BTXL6_20805 ENOG4107Y70 Heat shock protein BTXL6_20810 ENOG4105D8X mechanosensitive ion channel BTXL6_20815 ENOG4105BZU Histidine kinase BTXL6_20820 ENOG4105WH1 Two component transcriptional regulator luxr family BTXL6_20855 ENOG4105CMG Carbohydrate kinase BTXL6_20870 ENOG4108YV3 Protein of unknown function (DUF2711) BTXL6_20905 ENOG4108IJ8 ABC transporter BTXL6_20910 ENOG4105E90 ABC transporter BTXL6_20945 ENOG4105C37 (CBS) domain BTXL6_20970 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BTXL6_20985 ENOG4107S4Y M20 DapE family protein YgeY BTXL6_20990 ENOG4108TSC N-acetyltransferase BTXL6_20995 ENOG4108JUB Transcriptional regulator BTXL6_21000 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BTXL6_21040 ENOG4108N23 SpoOM-related protein BTXL6_21045 ENOG410841Q phosphoesterase PA-phosphatase related protein BTXL6_21055 ENOG4105SZ6 Thioredoxin BTXL6_21095 ENOG4108AEY RNA polymerase sigma factor BTXL6_21130 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTXL6_21165 ENOG4105CHR reductase BTXL6_21185 ENOG4105BZ4 penicillin-binding protein BTXL6_21195 ENOG4105CZM Major Facilitator BTXL6_21200 ENOG4105W8X HesB YadR YfhF-family protein BTXL6_21210 ENOG4105DXD 2-methylcitrate dehydratase BTXL6_21215 ENOG4105CR4 methylisocitrate lyase BTXL6_21220 ENOG4105C1G acyl-Coa dehydrogenase BTXL6_21225 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BTXL6_21235 ENOG4105N14 lysine exporter protein LysE YggA BTXL6_21240 ENOG4105E39 Enoyl-CoA hydratase BTXL6_21255 ENOG4107RFY SbcCD D subunit BTXL6_21285 ENOG4105FCD Major Facilitator BTXL6_21290 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BTXL6_21295 ENOG4105E4F Isochorismate synthase BTXL6_21300 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BTXL6_21305 ENOG4105WQI isochorismatase BTXL6_21310 ENOG4105CEY Amp-dependent synthetase and ligase BTXL6_21315 ENOG4105WQT MbtH domain protein BTXL6_21320 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTXL6_21335 ENOG4105K70 DNA-binding protein BTXL6_21355 ENOG4105BZG amino acid carrier protein BTXL6_21390 ENOG4105FE9 pseudouridine synthase BTXL6_21395 ENOG4105C22 threonyL-tRNA synthetase BTXL6_21405 ENOG4105C19 ABC transporter BTXL6_21415 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BTXL6_21445 ENOG4108D32 Methyltransferase BTXL6_21470 ENOG41081I9 integral membrane protein BTXL6_21480 ENOG4108Y4K DNA-binding transcriptional activator BTXL6_21495 ENOG4105C5X domain protein BTXL6_21505 ENOG4105EYF MMPL domain protein BTXL6_21525 ENOG4105WCN acetyltransferase BTXL6_21550 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BTXL6_21555 ENOG4105C1Q protoporphyrinogen oxidase BTXL6_21565 ENOG41068WN BTXL6_21575 ENOG4105VEQ Cold shock protein BTXL6_21595 ENOG410667J hydrolase BTXL6_21605 ENOG4107V2S Transcriptional regulator BTXL6_21610 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BTXL6_21625 ENOG4105DND Transcriptional regulator BTXL6_21630 ENOG4108RPX mosc domain containing protein BTXL6_21645 ENOG4105BZ1 (ABC) transporter BTXL6_21650 ENOG4105BZ1 (ABC) transporter BTXL6_21670 ENOG4108JCI Transcriptional regulator BTXL6_21700 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BTXL6_21715 ENOG4108KPJ rna polymerase sigma factor BTXL6_21740 ENOG4105F32 YngK protein BTXL6_21765 ENOG4105RD7 BadF BadG BcrA BcrD BTXL6_21775 ENOG4107STF Involved in phosphonate degradation (By similarity) BTXL6_21795 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BTXL6_21810 ENOG4105C1J atp-dependent rna helicase BTXL6_21830 ENOG4108RZE Tetr family transcriptional regulator BTXL6_21845 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BTXL6_21850 ENOG41088CC tellurite resistance protein tehB BTXL6_21860 ENOG4107RA9 decarboxylase BTXL6_21865 ENOG4105K56 Transcriptional regulator BTXL6_21895 ENOG4105CIN aminoacyl-histidine dipeptidase BTXL6_21905 ENOG4105EQK -acetyltransferase BTXL6_21915 ENOG4107RVG penicillin-binding protein BTXL6_21930 ENOG4107RF6 penicillin-binding protein BTXL6_21935 ENOG4107RF6 penicillin-binding protein BTXL6_21945 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BTXL6_21950 ENOG4105ETE Transcriptional regulator (LacI family BTXL6_21955 ENOG4105IE8 Alpha-ketoglutarate permease BTXL6_21960 ENOG4105CK5 oxidoreductase BTXL6_21985 ENOG4105D2N Aldolase BTXL6_21990 ENOG4105DH8 myo-inositol catabolism BTXL6_22005 ENOG4105F0V Cell wall hydrolase BTXL6_22010 ENOG4105EXC Acyl-transferase BTXL6_22065 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BTXL6_22070 ENOG4108XG2 Histidine kinase BTXL6_22075 ENOG4105WH1 Two component transcriptional regulator luxr family BTXL6_22080 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BTXL6_22100 ENOG4105BZU Histidine kinase BTXL6_22125 ENOG4105CZV ABC transporter BTXL6_22195 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BTXL6_22205 ENOG4105CEP NADH dehydrogenase BTXL6_22225 ENOG4105CJ1 ABC, transporter BTXL6_22235 ENOG4107Z3H Transcriptional regulator, TetR family BTXL6_22250 ENOG4105C1G acyl-Coa dehydrogenase BTXL6_22255 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BTXL6_22260 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BTXL6_22265 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BTXL6_22270 ENOG4105E39 Enoyl-CoA hydratase BTXL6_22275 ENOG4107QX3 carboxylase BTXL6_22280 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BTXL6_22300 ENOG4105DBI uridine monophosphokinase BTXL6_22325 ENOG4105T9C HD domain BTXL6_22335 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BTXL6_22370 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BTXL6_22385 ENOG4105FQP Beta-lactamase BTXL6_22395 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BTXL6_22400 ENOG4105KVH Transcriptional regulator BTXL6_22405 ENOG41089UC methyltransferase, type 11 BTXL6_22440 ENOG4105EFA 4-hydroxyphenylacetate BTXL6_22460 ENOG410900G Protein of unknown function (DUF421) BTXL6_22465 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) BTXL6_22470 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BTXL6_22490 ENOG4107SCA Formamidase (EC 3.5.1.49) BTXL6_22550 ENOG4105D6E homoserine dehydrogenase BTXL6_22565 ENOG4105ETU transcriptional activator (TenA BTXL6_22585 ENOG4105VTR Integrase BTXL6_22665 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BTXL6_22735 ENOG4105CAR Terminase, large subunit BTXL6_22745 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BTXL6_22895 ENOG410667J hydrolase BTXL6_22900 ENOG4105BZU Histidine kinase BTXL6_22930 ENOG4108HGU Histidine kinase BTXL6_22940 ENOG4105RHY Pfam:UPF0157 BTXL6_22945 ENOG4105CB2 alcohol dehydrogenase BTXL6_22950 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BTXL6_22955 ENOG4105CJN penicillin-binding protein BTXL6_22960 ENOG4108IG5 Transcriptional regulator BTXL6_22965 ENOG4105CHR reductase BTXL6_23015 ENOG4108V4B ThiJ pfpI BTXL6_23025 ENOG4107Y80 Major Facilitator superfamily BTXL6_23040 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTXL6_23060 ENOG4107Y9U Membrane BTXL6_23100 ENOG4105FCD Major Facilitator BTXL6_23115 ENOG4105E09 nadh pyrophosphatase BTXL6_23120 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTXL6_23155 ENOG4108XI2 Domain of unknown function (DUF1963) BTXL6_23180 ENOG4108NRW Phospholipase, patatin family BTXL6_23185 ENOG4105KWG Pfam:DUF1696 BTXL6_23220 ENOG4105PKS Excinuclease abc c subunit domain protein BTXL6_23265 ENOG4107VFR oxidoreductase BTXL6_23290 ENOG4105U0R haloacid dehalogenase-like hydrolase BTXL6_23310 ENOG4108IUM Glycogen debranching enzyme BTXL6_23325 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BTXL6_23335 ENOG4105FDR Membrane BTXL6_23345 ENOG4105CIS alcohol dehydrogenase BTXL6_23395 ENOG4105MSI germination protein ypeb BTXL6_23435 ENOG4107Z3H Transcriptional regulator, TetR family BTXL6_23455 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BTXL6_23475 ENOG4105E98 transcriptional regulator DeoR family BTXL6_23500 ENOG4107QKR Dehydrogenase BTXL6_23510 ENOG4107RUY (E1 component), alpha subunit BTXL6_23520 ENOG4105E1F short-chain dehydrogenase reductase BTXL6_23525 ENOG4105RHY Pfam:UPF0157 BTXL6_23565 ENOG4107SQ8 Glycine betaine BTXL6_23570 ENOG4108IJ7 Glycine betaine BTXL6_23600 ENOG41082BV acetyltransferase BTXL6_23605 ENOG4108M1A Chitin-binding protein BTXL6_23610 ENOG41087PP glycosyltransferase MGT family BTXL6_23635 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BTXL6_23640 ENOG4105MSB protein, conserved in bacteria BTXL6_23650 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BTXL6_23680 ENOG4108Z7F N-acetyltransferase BTXL6_23700 ENOG4105EEM helicase BTXL6_23720 ENOG4105C9U ATP-dependent DNA helicase RecQ BTXL6_23780 ENOG4108M1A Chitin-binding protein BTXL6_23800 ENOG4105BZG amino acid carrier protein BTXL6_23805 ENOG4105C26 Dehydrogenase BTXL6_23810 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BTXL6_23815 ENOG4105CTU Proline racemase BTXL6_23820 ENOG4105CTU Proline racemase BTXL6_23825 ENOG41080HI glycine oxidase BTXL6_23865 ENOG4107T5V SNARE associated Golgi BTXL6_23880 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BTXL6_23910 ENOG4105DTQ mandelate racemase muconate lactonizing BTXL6_23955 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) BTXL6_23960 ENOG4105BZU Histidine kinase BTXL6_23965 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BTXL6_24000 ENOG4105DPN Oligoendopeptidase f BTXL6_24005 ENOG4105EPR degv family BTXL6_24075 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) BTXL6_24080 ENOG4106K7D Major facilitator family transporter BTXL6_24105 ENOG4107BMA Transglycosylase associated protein BTXL6_24120 ENOG41089UC methyltransferase, type 11 BTXL6_24155 ENOG4105CHM Aminotransferase BTXL6_24170 ENOG4108ZMI UPF0477 protein BTXL6_24215 ENOG4105C02 permease BTXL6_24230 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BTXL6_24235 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BTXL6_24240 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BTXL6_24285 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BTXL6_24340 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BTXL6_24350 ENOG4107VMI polysaccharide deacetylase BTXL6_24355 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BTXL6_24365 ENOG4106ETB IIa component BTXL6_24370 ENOG4108ZCF integral membrane protein BTXL6_24375 ENOG4105E0M Sulfatase BTXL6_24380 ENOG4105C5H ABC transporter BTXL6_24390 ENOG4105EYF MMPL domain protein BTXL6_24395 ENOG41082JN Transcriptional regulator BTXL6_24415 ENOG4105CIH Imidazole acetol-phosphate transaminase BTXL6_24425 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BTXL6_24455 ENOG41069ER domain protein BTXL6_24470 ENOG4105D4B ABC, transporter BTXL6_24475 ENOG4105F5R ABC transporter BTXL6_24490 ENOG4105DKT Transcriptional regulator BTXL6_24495 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BTXL6_24505 ENOG41061GT Aldolase BTXL6_24530 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BTXL6_24565 ENOG4105II7 pyrroline-5-carboxylate reductase BTXL6_24575 ENOG4107258 Transcriptional regulator BTXL6_24595 ENOG4105ECK Fatty Acid Desaturase BTXL6_24605 ENOG4105G6Z alkaline phosphatase BTXL6_24615 ENOG4105VMP Transcriptional regulator BTXL6_24630 ENOG41090T1 Membrane BTXL6_24640 ENOG4108NEV two component transcriptional regulator, LytTR family BTXL6_24650 ENOG4105KNA -acetyltransferase BTXL6_24680 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTXL6_24700 ENOG4105C8Y Acetylornithine aminotransferase BTXL6_24745 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BTXL6_24750 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BTXL6_24755 ENOG4105CHH sulfate transporter BTXL6_24775 ENOG4108TVJ Nitroreductase BTXL6_24780 ENOG4105FS7 Transcriptional regulator BTXL6_24795 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BTXL6_24800 ENOG4105WEC Molybdate metabolism regulator BTXL6_24805 ENOG4105CMR udp-glucose 4-epimerase BTXL6_24810 ENOG4105C19 ABC transporter BTXL6_24840 ENOG4108XET gCN5-related N-acetyltransferase BTXL6_24900 ENOG410635A Membrane BTXL6_24910 ENOG4108IQI permease BTXL6_24920 ENOG4105F1N DNA alkylation repair BTXL6_24955 ENOG4107RF6 penicillin-binding protein BTXL6_24995 ENOG4105P4J Allophanate hydrolase, subunit 1 BTXL6_25000 ENOG4107258 Transcriptional regulator BTXL6_25010 ENOG4106N3A copper homeostasis protein cutc BTXL6_25015 ENOG4108ZRV stage ii sporulation protein p BTXL6_25020 ENOG4105FDT acyl-CoA dehydrogenase BTXL6_25035 ENOG4105DWD nucleoside recognition domain protein BTXL6_25065 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BTXL6_25095 ENOG4105E2A Dehydrogenase BTXL6_25100 ENOG4108IJ0 Aspartate ammonia-lyase BTXL6_25105 ENOG4105HDK L-asparaginase BTXL6_25110 ENOG4108IMY Transcriptional regulator BTXL6_25120 ENOG4105BZU Histidine kinase BTXL6_25145 ENOG41075H3 AraC family transcriptional regulator BTXL6_25155 ENOG4105YWU small acid-soluble spore protein BTXL6_25160 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BTXL6_25165 ENOG4105CUB amino acid BTXL6_25170 ENOG4105II7 pyrroline-5-carboxylate reductase BTXL6_25175 ENOG4108NHD germination protein BTXL6_25180 ENOG4108Q8B Spore germination protein BTXL6_25200 ENOG4105CSV Glutaminase BTXL6_25230 ENOG4105CGH 5'-nucleotidase BTXL6_25235 ENOG4105CH6 catalase BTXL6_25245 ENOG4105CHJ isochorismatase hydrolase BTXL6_25320 ENOG4105E1K spore germination protein BTXL6_25340 ENOG4108606 TspO/MBR family BTXL6_25345 ENOG4105CVP deoxyribo-dipyrimidine photolyase BTXL6_25370 ENOG4108TWJ NADH dehydrogenase subunit 5 BTXL6_25375 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BTXL6_25385 ENOG4108Q5U germination protein, ger(x)c family BTXL6_25390 ENOG4105E1K spore germination protein BTXL6_25400 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BTXL6_25410 ENOG4105C19 ABC transporter BTXL6_25425 ENOG4108NEV two component transcriptional regulator, LytTR family BTXL6_25445 ENOG4105D6J arsenicaL-resistance protein BTXL6_25450 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase BTXL6_25455 ENOG41085FC arsR family transcriptional regulator BTXL6_25465 ENOG4105NAE bifunctional deaminase-reductase domain protein BTXL6_25475 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BTXL6_25505 ENOG4107P5I polyketide synthase BTXL6_25510 ENOG4108IG5 Transcriptional regulator BTXL6_25520 ENOG4105EQ0 Major Facilitator superfamily BTXL6_25525 ENOG4108JGH Tetr family transcriptional regulator BTXL6_25555 ENOG4105CHR reductase BTXL6_25560 ENOG4108YXU transcriptional regulator AsnC family BTXL6_25605 ENOG4105ED2 Beta-lactamase BTXL6_25610 ENOG4105N0V mono-oxygenase ydhR BTXL6_25625 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BTXL6_25630 ENOG4105C0R drug resistance transporter emrb qaca subfamily BTXL6_25645 ENOG4108NIW Leucine export protein LeuE BTXL6_25675 ENOG4105K6H D-cysteine desulfhydrase BTXL6_25695 ENOG4105VZ8 Transcriptional regulator BTXL6_25715 ENOG4105JQZ Methyltransferase BTXL6_25735 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BTXL6_25755 ENOG4105BZU Histidine kinase BTXL6_25765 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BTXL6_25790 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BTXL6_25830 ENOG4105C44 Serine transporter BTXL6_25835 ENOG4105EJQ L-serine dehydratase BTXL6_25850 ENOG4108JPW Aminotransferase BTXL6_25865 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BTXL6_25875 ENOG4105DVH amino acid BTXL6_25895 ENOG4108JQ1 Dehydrogenase BTXL6_25915 ENOG41082W1 Cupin 2, conserved barrel domain protein BTXL6_25920 ENOG410874W AraC family transcriptional regulator BTXL6_25935 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BTXL6_25965 ENOG4108VXD carboxy-peptidase BTXL6_25970 ENOG4105PNM synthesis protein BTXL6_25980 ENOG4108ISG Major Facilitator BTXL6_25995 ENOG4107MII Sugar-specific transcriptional regulator TrmB BTXL6_26000 ENOG4105CZM Major Facilitator BTXL6_26015 ENOG4105DA5 (ABC) transporter BTXL6_26020 ENOG41069JR BTXL6_26030 ENOG4105RXJ BTXL6_26035 ENOG4105KPY Small multidrug resistance protein BTXL6_26040 ENOG4105KBX Transcriptional regulator, TetR family BTXL6_26045 ENOG4107AUC BTXL6_26060 ENOG4105CRW Short chain fatty acid transporter BTXL6_26100 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BTXL6_26125 ENOG4108K8S endonuclease I BTXL6_26140 ENOG41067QW Transcriptional regulator BTXL6_26155 ENOG4108Z66 YbaK ebsC protein BTXL6_26175 ENOG4105KVH Transcriptional regulator BTXL6_26180 ENOG4108RCM Nitroreductase BTXL6_26200 ENOG4108PSK reductase BTXL6_26210 ENOG4105CJ1 ABC, transporter BTXL6_26265 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BTXL6_26270 ENOG4105E2R ROK family BTXL6_26275 ENOG4108UW5 maltose o-acetyltransferase BTXL6_26285 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BTXL6_26290 ENOG4105C31 Tryptophanyl-tRNA synthetase BTXL6_26330 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BTXL6_26340 ENOG4105EV4 Multidrug resistance protein mdtH BTXL6_26370 ENOG4105C37 (CBS) domain BTXL6_26385 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BTXL6_26390 ENOG4105FAW cDP-glucose 4,6-dehydratase BTXL6_26415 ENOG4105DDN Pentapeptide repeat-containing protein BTXL6_26420 ENOG4105XDF Protein of unknown function (DUF1272) BTXL6_26425 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BTXL6_26430 ENOG4105CMG Carbohydrate kinase BTXL6_26435 ENOG4105C6Z Gluconate BTXL6_26440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BTXL6_26455 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BTXL6_26460 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BTXL6_26465 ENOG4105CIS alcohol dehydrogenase BTXL6_26470 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone BTXL6_26490 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BTXL6_26505 ENOG4105C8Q Methyl-accepting chemotaxis BTXL6_26510 ENOG4108UX3 '-nucleotidase BTXL6_26515 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BTXL6_26520 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BTXL6_26525 ENOG4105KVH Transcriptional regulator BTXL6_26540 ENOG4105CV8 reductase BTXL6_26545 ENOG4105F27 Major Facilitator BTXL6_26560 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BTXL6_26565 ENOG4105C44 Serine transporter BTXL6_26595 ENOG4105KVH Transcriptional regulator BTXL6_26600 ENOG4108TZY GntR Family Transcriptional Regulator BTXL6_26605 ENOG4105D9R oxidoreductase BTXL6_26610 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BTXL6_26615 ENOG4105KVH Transcriptional regulator BTXL6_26620 ENOG4105KVH Transcriptional regulator BTXL6_26660 ENOG4105JAB phenazine biosynthesis protein, phzf family BTXL6_26670 ENOG4105CHR reductase BTXL6_26680 ENOG4105KNA -acetyltransferase BTXL6_26690 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BTXL6_26695 ENOG4105KVH Transcriptional regulator BTXL6_26715 ENOG4108ZJ4 polysaccharide deacetylase BTXL6_26755 ENOG4105KAF membrAne BTXL6_26785 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BTXL6_26800 ENOG4107YXZ hydrolase, family 25 BTXL6_26835 ENOG4105H3G oxidoreductase BTXL6_26905 ENOG4108TN2 lmbE family BTXL6_26915 ENOG4107R3E Citrate transporter BTXL6_26930 ENOG4108MES Periplasmic binding protein BTXL6_26935 ENOG4105EHG Permease protein BTXL6_26940 ENOG4105DQ5 transport system permease protein BTXL6_26945 ENOG4105NX3 Membrane BTXL6_26965 ENOG41068WN BTXL6_26970 ENOG4107CUJ Protein of unknown function (DUF2690) BTXL6_26980 ENOG4107V2S Transcriptional regulator BTXL6_27000 ENOG4105C98 muts2 protein BTXL6_27010 ENOG4105E5K Alpha-amylase BTXL6_27015 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BTXL6_27020 ENOG4105DPN Oligoendopeptidase f BTXL6_27045 ENOG4105FFC UPF0187 protein BTXL6_27060 ENOG4108A04 Beta-lactamase BTXL6_27090 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BTXL6_27100 ENOG41082BM Transcriptional regulator, arsr family BTXL6_27105 ENOG4105CB2 alcohol dehydrogenase BTXL6_27115 ENOG4107JM4 Tetratricopeptide repeat BTXL6_27140 ENOG4105C09 Bile acid BTXL6_27145 ENOG4105CQB FAD linked oxidase domain protein BTXL6_27160 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BTXL6_27185 ENOG4105FA2 dna polymerase iii BTXL6_27195 ENOG4105EKQ RNA-directed DNA polymerase BTXL6_27230 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BTXL6_27270 ENOG4107JM4 Tetratricopeptide repeat BTXL6_27345 ENOG4105KRN Transcriptional regulator, abrb family BTXL6_27350 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BTXL6_27355 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BTXL6_27425 ENOG4105TQK DNA polymerase iii, delta' subunit BTXL6_27535 ENOG4105C3F Signal peptidase i BTXL6_27565 ENOG4105C6E dna polymerase iii BTXL6_27595 ENOG4105WH1 Two component transcriptional regulator luxr family BTXL6_27600 ENOG4105BZU Histidine kinase BTXL6_27800 ENOG4105CDU Replicative dna helicase BTXL6_27930 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BTXL6_28095 ENOG4105BZU Histidine kinase BTXL6_28115 ENOG410625E BTXL6_28120 ENOG4106A3M Cytochrome p-450 BTXL6_28240 ENOG4105E1K spore germination protein BTXL6_28295 ENOG4106F1P AAA ATPase, central domain protein BTXL6_28300 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BTXL6_28410 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BTXL6_28455 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BTXL6_28525 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BTXL6_28540 ENOG4107Y9E nuclease BTXL6_28585 ENOG4105FA0 parb-like partition protein BTXL6_28680 ENOG4105DQ6 Transposase BTXL6_28750 ENOG4105D13 transposase BTXL6_28840 ENOG4105DQ6 Transposase BTXL6_28905 ENOG4105DQ6 Transposase