locus-tag class description XI92_00025 ENOG41075H3 AraC family transcriptional regulator XI92_00045 ENOG4105CGH 5'-nucleotidase XI92_00055 ENOG4105CHJ isochorismatase hydrolase XI92_00150 ENOG4108606 TspO/MBR family XI92_00155 ENOG4105CVP deoxyribo-dipyrimidine photolyase XI92_00180 ENOG4105F2M alpha beta hydrolase fold-3 domain protein XI92_00195 ENOG4108TWJ NADH dehydrogenase subunit 5 XI92_00200 ENOG4105GPN Uncharacterized conserved protein (DUF2294) XI92_00205 ENOG4107VMI polysaccharide deacetylase XI92_00210 ENOG4105KY5 gCN5-related N-acetyltransferase XI92_00215 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase XI92_00220 ENOG4105ECQ AraC Family Transcriptional Regulator XI92_00225 ENOG4105Z7P Acetyltransferase (GNAT) family XI92_00240 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase XI92_00245 ENOG41085FC arsR family transcriptional regulator XI92_00255 ENOG4105F27 Major Facilitator XI92_00260 ENOG4105M4P Tetr family transcriptional regulator XI92_00265 ENOG4105CYX Short-chain dehydrogenase reductase Sdr XI92_00270 ENOG4108YXU transcriptional regulator AsnC family XI92_00355 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) XI92_00360 ENOG4105C0R drug resistance transporter emrb qaca subfamily XI92_00380 ENOG4105K6H D-cysteine desulfhydrase XI92_00390 ENOG4105E0Y RtcB Protein XI92_00400 ENOG4105JQZ Methyltransferase XI92_00420 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) XI92_00425 ENOG4105BZU Histidine kinase XI92_00435 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) XI92_00465 ENOG4108JQ1 Dehydrogenase XI92_00470 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) XI92_00495 ENOG4108KDT Molybdate metabolism regulator XI92_00505 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase XI92_00585 ENOG4105CJW magnesium transporter XI92_00595 ENOG4105EKQ RNA-directed DNA polymerase XI92_00640 ENOG4105W8Z 4'-phosphopantetheinyl transferase XI92_00675 ENOG4105EQK -acetyltransferase XI92_00680 ENOG4105EJ9 Membrane XI92_00690 ENOG4105DQ6 Transposase XI92_00695 ENOG4105IYK transposase XI92_00700 ENOG4105KRN Transcriptional regulator, abrb family XI92_00725 ENOG4105CIN aminoacyl-histidine dipeptidase XI92_00750 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) XI92_00755 ENOG4105K56 Transcriptional regulator XI92_00760 ENOG4107RA9 decarboxylase XI92_00765 ENOG4108I0C methyltransferase XI92_00775 ENOG41088CC tellurite resistance protein tehB XI92_00790 ENOG4108RZE Tetr family transcriptional regulator XI92_00800 ENOG4105C1J atp-dependent rna helicase XI92_00810 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) XI92_00830 ENOG4108INS Transcriptional regulator XI92_00835 ENOG4105C7B Threonine dehydratase XI92_00850 ENOG4105RD7 BadF BadG BcrA BcrD XI92_00875 ENOG4105F32 YngK protein XI92_00900 ENOG4108KPJ rna polymerase sigma factor XI92_00905 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) XI92_00940 ENOG4108JCI Transcriptional regulator XI92_00970 ENOG4105BZ1 (ABC) transporter XI92_00975 ENOG4105BZ1 (ABC) transporter XI92_00990 ENOG4108RPX mosc domain containing protein XI92_00995 ENOG4105DND Transcriptional regulator XI92_01015 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) XI92_01020 ENOG4107V2S Transcriptional regulator XI92_01050 ENOG41068WN XI92_01060 ENOG4105C1Q protoporphyrinogen oxidase XI92_01085 ENOG4105WCN acetyltransferase XI92_01120 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) XI92_01145 ENOG4108Y4K DNA-binding transcriptional activator XI92_01155 ENOG41081I9 integral membrane protein XI92_01195 ENOG4105C19 ABC transporter XI92_01200 ENOG4105C22 threonyL-tRNA synthetase XI92_01205 ENOG4105FE9 pseudouridine synthase XI92_01225 ENOG4105BZG amino acid carrier protein XI92_01245 ENOG4105K70 DNA-binding protein XI92_01260 ENOG4105C0R drug resistance transporter emrb qaca subfamily XI92_01265 ENOG4105WQT MbtH domain protein XI92_01270 ENOG4105CEY Amp-dependent synthetase and ligase XI92_01275 ENOG4105WQI isochorismatase XI92_01280 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase XI92_01285 ENOG4105E4F Isochorismate synthase XI92_01290 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase XI92_01295 ENOG4105FCD Major Facilitator XI92_01320 ENOG4105EYH Exonuclease XI92_01325 ENOG4107RFY SbcCD D subunit XI92_01340 ENOG4105E39 Enoyl-CoA hydratase XI92_01345 ENOG4105N14 lysine exporter protein LysE YggA XI92_01355 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase XI92_01360 ENOG4105C1G acyl-Coa dehydrogenase XI92_01365 ENOG4105CR4 methylisocitrate lyase XI92_01370 ENOG4105DXD 2-methylcitrate dehydratase XI92_01380 ENOG4105W8X HesB YadR YfhF-family protein XI92_01385 ENOG4105CZM Major Facilitator XI92_01395 ENOG4105BZ4 penicillin-binding protein XI92_01460 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) XI92_01495 ENOG4105SZ6 Thioredoxin XI92_01505 ENOG410841Q phosphoesterase PA-phosphatase related protein XI92_01550 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein XI92_01555 ENOG4108JUB Transcriptional regulator XI92_01560 ENOG4108TSC N-acetyltransferase XI92_01565 ENOG4107S4Y M20 DapE family protein YgeY XI92_01580 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) XI92_01605 ENOG4105C37 (CBS) domain XI92_01640 ENOG4105E90 ABC transporter XI92_01645 ENOG4108IJ8 ABC transporter XI92_01675 ENOG4108YV3 Protein of unknown function (DUF2711) XI92_01685 ENOG4105C6Z Gluconate XI92_01690 ENOG4105CMG Carbohydrate kinase XI92_01710 ENOG4107ZY0 Phenazine biosynthesis-like protein XI92_01715 ENOG4106KNT transcriptional regulator XI92_01720 ENOG4105WH1 Two component transcriptional regulator luxr family XI92_01725 ENOG4105BZU Histidine kinase XI92_01730 ENOG4105D8X mechanosensitive ion channel XI92_01760 ENOG4105F0I Aminotransferase XI92_01765 ENOG4108MES Periplasmic binding protein XI92_01785 ENOG4105CAQ asparagine synthetase XI92_01790 ENOG4107Y70 Heat shock protein XI92_01795 ENOG4108KF3 Electron transport protein SCO1 SenC XI92_01805 ENOG4108RCR degv family XI92_01815 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) XI92_01825 ENOG4108UT2 hemolysin iii XI92_01830 ENOG4105E9Q Acyl-transferase XI92_01835 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) XI92_01850 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) XI92_01855 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) XI92_01870 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 XI92_01895 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase XI92_01900 ENOG4105VMP Transcriptional regulator XI92_01910 ENOG4105KD7 acetyltransferase XI92_01930 ENOG4105CY2 Citrate transporter XI92_01955 ENOG4105C8J )-transporter XI92_01960 ENOG4105C5S asparaginyl-tRNA synthetase XI92_01970 ENOG4105IYK transposase XI92_01975 ENOG4105DQ6 Transposase XI92_01995 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) XI92_02020 ENOG4105C75 arginyL-tRNA synthetase XI92_02025 ENOG4107YX5 Pfam:DUF548 XI92_02050 ENOG4108UUM single-stranded DNA-binding protein XI92_02160 ENOG4105C5H ABC transporter XI92_02190 ENOG4108KU9 integrase family XI92_02205 ENOG4107TSN permease XI92_02230 ENOG4105MCT stage V sporulation protein S XI92_02265 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) XI92_02270 ENOG4108IFG nitrite reductase, (NAD(P)H) XI92_02275 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit XI92_02280 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) XI92_02285 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein XI92_02290 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein XI92_02305 ENOG41067WU Molybdopterin converting factor (Subunit 1) XI92_02310 ENOG4108ZAF Molybdopterin XI92_02315 ENOG4105CVM Molybdenum cofactor synthesis domain protein XI92_02320 ENOG4105D06 uba thif-type nad fad binding protein XI92_02325 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) XI92_02330 ENOG4107V6Q Cyclic nucleotide-binding domain XI92_02340 ENOG4105R3A Nitrate reductase XI92_02345 ENOG4108IUE nitrate reductase beta subunit XI92_02360 ENOG4105C7R Atpase associated with various cellular activities aaa_3 XI92_02375 ENOG4108V06 Glutathione peroxidase XI92_02390 ENOG4105CNW domain protein XI92_02405 ENOG4105EMN RNA polymerase sigma factor XI92_02415 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein XI92_02425 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily XI92_02430 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) XI92_02450 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) XI92_02475 ENOG4105KBJ sporulation protein ytfj XI92_02570 ENOG4108MGT Required for secretion of EsxA and EsxB XI92_02575 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) XI92_02605 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) XI92_02635 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family XI92_02640 ENOG4108JYZ YitT family XI92_02645 ENOG41087PP glycosyltransferase MGT family XI92_02655 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) XI92_02710 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis XI92_02720 ENOG41085W3 Transposase XI92_02755 ENOG4105EKQ RNA-directed DNA polymerase XI92_02805 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) XI92_02815 ENOG4105CAR Terminase, large subunit XI92_02940 ENOG4106050 phage regulatory protein, rha family XI92_02980 ENOG4108ZRV stage ii sporulation protein p XI92_03010 ENOG4108VXD carboxy-peptidase XI92_03020 ENOG4108ZRV stage ii sporulation protein p XI92_03040 ENOG4108Z7R Chaperone CsaA XI92_03050 ENOG4105IYK transposase XI92_03055 ENOG4105DQ6 Transposase XI92_03070 ENOG4105C37 (CBS) domain XI92_03075 ENOG4105SXS Protein of unknown function (DUF456) XI92_03095 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) XI92_03100 ENOG4108S4H thioesterase Superfamily protein XI92_03110 ENOG4108PJD permease XI92_03125 ENOG4107T5V SNARE associated Golgi XI92_03170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) XI92_03180 ENOG4105K4T epimerase XI92_03190 ENOG4105EKQ RNA-directed DNA polymerase XI92_03210 ENOG4105DSE periplasmic solute binding protein XI92_03220 ENOG4105CKI cobalamin synthesis protein XI92_03230 ENOG4107QM2 Aldo Keto reductase XI92_03235 ENOG4105VMI -acetyltransferase XI92_03250 ENOG4105DEN Luciferase family XI92_03260 ENOG4105DQ6 Transposase XI92_03275 ENOG4108WPJ Ferritin-like domain XI92_03280 ENOG4108K88 Membrane XI92_03300 ENOG4105C8Q Methyl-accepting chemotaxis XI92_03325 ENOG4105KAF membrAne XI92_03335 ENOG4107XZQ multidrug resistance protein XI92_03340 ENOG4105CPC Aldo Keto reductase XI92_03345 ENOG4105YVS arsR family transcriptional regulator XI92_03355 ENOG4105KRN Transcriptional regulator, abrb family XI92_03405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family XI92_03410 ENOG4108ZUB Lysine exporter protein (Lyse ygga) XI92_03420 ENOG4105YWU small acid-soluble spore protein XI92_03425 ENOG4108WBH protein TIM barrel XI92_03440 ENOG4105CEY Amp-dependent synthetase and ligase XI92_03470 ENOG4105D7V transposase XI92_03480 ENOG4105VRR gCN5-related N-acetyltransferase XI92_03485 ENOG4105KT7 mgtC SapB transporter XI92_03495 ENOG4107VMI polysaccharide deacetylase XI92_03500 ENOG4105BZU Histidine kinase XI92_03505 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XI92_03515 ENOG4108KGH TRANSCRIPTIONal XI92_03530 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) XI92_03540 ENOG4105D6E homoserine dehydrogenase XI92_03545 ENOG41085W3 Transposase XI92_03565 ENOG4108ZJ4 polysaccharide deacetylase XI92_03570 ENOG41075D4 Aminoglycoside 6-adenylyltransferase XI92_03580 ENOG4105BZU Histidine kinase XI92_03585 ENOG4105EFI regulatoR XI92_03590 ENOG4105BZ1 (ABC) transporter XI92_03645 ENOG4108UT6 Transferase hexapeptide repeat containing protein XI92_03655 ENOG4105K64 Glycosyl transferase, family 2 XI92_03665 ENOG4108JJ8 (ABC) transporter XI92_03670 ENOG4108JJ9 ABC, transporter XI92_03675 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii XI92_03680 ENOG4105C4M (Ubiquinol oxidase) subunit I XI92_03710 ENOG4105EGI Transcriptional regulator XI92_03720 ENOG4105C32 Amino acid ABC transporter (Permease) XI92_03725 ENOG4108IV0 ABC, transporter XI92_03730 ENOG4105C0Z ABC transporter XI92_03740 ENOG4105CKI cobalamin synthesis protein XI92_03750 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) XI92_03755 ENOG4106F5Q Membrane XI92_03770 ENOG4108TVJ Nitroreductase XI92_03775 ENOG4107ZXU DSBA oxidoreductase XI92_03780 ENOG4108Z40 Transcriptional regulator XI92_03785 ENOG4105GZI Transcriptional regulator XI92_03790 ENOG4107RT3 EamA-like transporter family XI92_03795 ENOG4105KTB nuclear export factor GLE1 XI92_03845 ENOG4107R16 Multicopper oxidase XI92_03855 ENOG4107RAQ aminopeptidase XI92_03880 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) XI92_03885 ENOG4105D9N nucleoside XI92_03895 ENOG4107RHR regulatoR XI92_03910 ENOG4105K8R UPF0145 protein XI92_03935 ENOG4105C0X amino acid XI92_03945 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) XI92_03960 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) XI92_03965 ENOG41068WN XI92_03985 ENOG4105K5X acetyltransferase XI92_03990 ENOG4105CYC Transferase XI92_03995 ENOG4105DY9 regulatoR XI92_04005 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b XI92_04010 ENOG4105C6X Major Facilitator XI92_04035 ENOG4105C7B Threonine dehydratase XI92_04040 ENOG4105C01 Dihydroxy-acid dehydratase XI92_04045 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase XI92_04055 ENOG4105C7K acetolactate synthase XI92_04060 ENOG4105CM2 brancheD-chain amino acid aminotransferase XI92_04065 ENOG4105CHR reductase XI92_04090 ENOG4105H67 Protein of unknown function (DUF421) XI92_04095 ENOG4105X5K response regulator receiver protein XI92_04100 ENOG4105C8J )-transporter XI92_04120 ENOG4105C6T cysteine synthase XI92_04125 ENOG4105EU0 Major facilitator Superfamily XI92_04130 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) XI92_04140 ENOG4105DXI Major Facilitator superfamily XI92_04150 ENOG4105U3E Transcriptional regulator XI92_04155 ENOG4105CSR polyphosphate kinase 2 XI92_04170 ENOG4105E09 nadh pyrophosphatase XI92_04175 ENOG4105FVX XI92_04205 ENOG41067QW Transcriptional regulator XI92_04250 ENOG4105C6K Malic enzyme XI92_04255 ENOG4108IJ0 Aspartate ammonia-lyase XI92_04270 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) XI92_04295 ENOG4105CJ1 ABC, transporter XI92_04330 ENOG4106BRA Membrane XI92_04350 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen XI92_04370 ENOG4105EC3 peptidase S51, dipeptidase E XI92_04375 ENOG4107QJQ Mate efflux family protein XI92_04400 ENOG4105C9Q fumarate hydratase class II XI92_04410 ENOG4105VUF Transcriptional regulator XI92_04415 ENOG4105DFD Na H antiporter XI92_04430 ENOG4108PJD permease XI92_04435 ENOG4105CKI cobalamin synthesis protein XI92_04450 ENOG4105DRR Transcriptional regulator, GntR family XI92_04460 ENOG4105PGM cation diffusion facilitator family transporter XI92_04480 ENOG4105CAQ asparagine synthetase XI92_04500 ENOG41085W3 Transposase XI92_04505 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) XI92_04515 ENOG4105CVJ phosphoglycerate mutase XI92_04545 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component XI92_04550 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein XI92_04560 ENOG4105DUM transcriptional regulator, lysR family XI92_04620 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) XI92_04625 ENOG4105KTQ flagellar basal-body rod protein XI92_04630 ENOG4105FZW flagellar biosynthesis regulator FlhF XI92_04635 ENOG4105D7B Flagellar biosynthesis protein flha XI92_04640 ENOG4105D00 flagellar biosynthetic protein flhB XI92_04650 ENOG4105VS8 Flagellar biosynthetic protein fliq XI92_04655 ENOG4105CN7 Flagellar biosynthetic protein FliP XI92_04665 ENOG4105DD5 Flagellar motor switch protein XI92_04670 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) XI92_04680 ENOG4105E4C Lytic transglycosylase catalytic XI92_04685 ENOG4105I03 Flagellin XI92_04690 ENOG4105I03 Flagellin XI92_04695 ENOG4105I03 Flagellin XI92_04700 ENOG4105I03 Flagellin XI92_04710 ENOG4107R88 Chemotaxis protein (CheV) XI92_04725 ENOG4105BZE flagellar hook protein, FlgE XI92_04760 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) XI92_04765 ENOG4107U2N Flagellar M-ring protein XI92_04770 ENOG41075Z6 flagellar hook-basal body complex protein fliE XI92_04775 ENOG4108ZC9 flagellar basal-body rod protein flgc XI92_04780 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) XI92_04800 ENOG4105DTJ flagellar hook-associated protein XI92_04805 ENOG4105E1Q flagellar hook-associated protein XI92_04825 ENOG4105BZU Histidine kinase XI92_04840 ENOG4105DD5 Flagellar motor switch protein XI92_04845 ENOG4105CBS Chea signal transduction histidine kinase XI92_04850 ENOG4107YTP response regulator receiver protein XI92_04855 ENOG4105ER2 Ompa motb domain protein XI92_04860 ENOG4107R0U MotA TolQ exbB proton channel XI92_04870 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) XI92_04910 ENOG41080C8 DUF218 domain XI92_04915 ENOG4105H67 Protein of unknown function (DUF421) XI92_04925 ENOG4108Z5V transcriptional regulator, merr family XI92_04930 ENOG4105CN5 Metallo-Beta-Lactamase XI92_04935 ENOG4107RWR Sodium hydrogen exchanger XI92_05010 ENOG41081VK Ribonuclease XI92_05030 ENOG4108SZE gCN5-related N-acetyltransferase XI92_05045 ENOG4105CPK Glycosyl transferase (Group 1 XI92_05075 ENOG4105HTX biosynthesis protein XI92_05120 ENOG4105KHC sulfurtransferase XI92_05130 ENOG4108W0I acetyltransferase XI92_05140 ENOG410890F Dynamin family XI92_05145 ENOG4105DHF Membrane XI92_05150 ENOG4105C2W permease XI92_05155 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) XI92_05160 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) XI92_05170 ENOG4105CTD carboxy-peptidase XI92_05175 ENOG4105DVT helicase XI92_05185 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) XI92_05195 ENOG4106F55 Protein of unknown function (DUF1273) XI92_05235 ENOG4105BZ4 penicillin-binding protein XI92_05245 ENOG4105CSM endonuclease III XI92_05265 ENOG4105YAC XI92_05270 ENOG4105DVT helicase XI92_05310 ENOG4105CPK Glycosyl transferase (Group 1 XI92_05315 ENOG4105FJR Lmbe family XI92_05330 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase XI92_05335 ENOG4108JYZ YitT family XI92_05345 ENOG4105DQ6 Transposase XI92_05380 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) XI92_05385 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) XI92_05400 ENOG41068YB TPR repeat-containing protein XI92_05420 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase XI92_05425 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) XI92_05430 ENOG4105EAH synthase XI92_05440 ENOG4105XXQ heptaprenyl diphosphate synthase component I XI92_05455 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) XI92_05485 ENOG41065D1 XI92_05490 ENOG4105S2F XI92_05505 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) XI92_05525 ENOG4107RB3 L-asparaginase XI92_05530 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase XI92_05555 ENOG4108S6Z Negative regulator of genetic competence XI92_05560 ENOG4108XDN Transcriptional regulator XI92_05565 ENOG4107RGJ metallophosphoesterase XI92_05575 ENOG4105I7S Abortive infection protein XI92_05580 ENOG4105C9U ATP-dependent DNA helicase RecQ XI92_05595 ENOG4108SAX Membrane XI92_05610 ENOG4108WBT adenosyltransferase XI92_05620 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_05625 ENOG4105CRE cytochrome C XI92_05630 ENOG4107TWT Cytochrome c biogenesis protein XI92_05635 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen XI92_05640 ENOG4105FE9 pseudouridine synthase XI92_05650 ENOG4108JIC nucleoside recognition domain protein XI92_05655 ENOG4105DZ1 carboxypeptidase XI92_05660 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) XI92_05690 ENOG4105BZU Histidine kinase XI92_05705 ENOG4105I3N Conserved Protein XI92_05710 ENOG4105BZU Histidine kinase XI92_05725 ENOG4105BZ4 penicillin-binding protein XI92_05730 ENOG4107GRR phosphate transport regulator XI92_05735 ENOG4105CJ3 phosphate transporter XI92_05760 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) XI92_05785 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) XI92_05805 ENOG4105WH1 Two component transcriptional regulator luxr family XI92_05810 ENOG4105ENE Histidine kinase XI92_05830 ENOG4105DFD Na H antiporter XI92_05850 ENOG4105C8J )-transporter XI92_05860 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein XI92_05870 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) XI92_05880 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) XI92_05885 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) XI92_05890 ENOG4107S4M Sulfate adenylate transferase XI92_05905 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) XI92_05915 ENOG4105E0M Sulfatase XI92_05920 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase XI92_05935 ENOG4107RVV histidinol phosphate phosphatase, hisj family XI92_05950 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) XI92_05955 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase XI92_05960 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) XI92_05965 ENOG4105ECC imidazole-glycerol-phosphate dehydratase XI92_05970 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) XI92_05975 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) XI92_05990 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) XI92_06005 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase XI92_06010 ENOG4108ZP8 Acetolactate synthase small subunit XI92_06015 ENOG4105C7K acetolactate synthase XI92_06020 ENOG4105CM2 brancheD-chain amino acid aminotransferase XI92_06050 ENOG4105KBJ sporulation protein ytfj XI92_06055 ENOG41063Y9 XI92_06060 ENOG4105CZN Potassium uptake protein XI92_06125 ENOG4105NQC Flavodoxin XI92_06150 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein XI92_06160 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD XI92_06165 ENOG4105EA8 2-Nitropropane dioxygenase XI92_06170 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A XI92_06210 ENOG4105CJ1 ABC, transporter XI92_06220 ENOG4105CZV ABC transporter XI92_06225 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family XI92_06240 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) XI92_06245 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) XI92_06295 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) XI92_06300 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase XI92_06305 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) XI92_06310 ENOG4105BZU Histidine kinase XI92_06320 ENOG4106DF1 XI92_06330 ENOG41090MY MarR family Transcriptional regulator XI92_06335 ENOG4105BZU Histidine kinase XI92_06345 ENOG4105PXI polysaccharide deacetylase XI92_06355 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) XI92_06370 ENOG4105E98 transcriptional regulator DeoR family XI92_06390 ENOG4107RCV ABC transporter, permease XI92_06395 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) XI92_06400 ENOG4105C4Y ABC transporter XI92_06430 ENOG4105CHR reductase XI92_06450 ENOG4108Z7G MaoC domain protein dehydratase XI92_06455 ENOG410681C small acid-soluble spore protein XI92_06460 ENOG4105CZN Potassium uptake protein XI92_06465 ENOG4107TS3 membrane protein, TerC XI92_06470 ENOG4108QTI )-transporter XI92_06480 ENOG4106A3R peptidase XI92_06500 ENOG4105JXH GntR family transcriptional regulator XI92_06505 ENOG4105BZU Histidine kinase XI92_06510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_06525 ENOG4105CQB FAD linked oxidase domain protein XI92_06530 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) XI92_06535 ENOG4105K4I Scp-like extracellular XI92_06545 ENOG4108YBP pseudouridine synthase XI92_06555 ENOG4105EYF MMPL domain protein XI92_06565 ENOG4107RUE extracellular solute-binding protein family 1 XI92_06570 ENOG4105D38 putrescine abc transporter XI92_06575 ENOG4105F38 ABC transporter, permease XI92_06580 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) XI92_06585 ENOG4105C26 Dehydrogenase XI92_06620 ENOG4105VFR signal peptidase XI92_06625 ENOG4105DZ1 carboxypeptidase XI92_06635 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) XI92_06655 ENOG4105RHA ABC transporter, permease XI92_06660 ENOG4108IUX (ABC) transporter XI92_06675 ENOG4105DQ6 Transposase XI92_06710 ENOG4105VZ8 Transcriptional regulator XI92_06715 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 XI92_06720 ENOG4105C7S Dehydrogenase XI92_06740 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) XI92_06745 ENOG4105DQ6 Transposase XI92_06820 ENOG4105DK0 Indole-3-glycerol phosphate synthase XI92_06830 ENOG4105DDQ anthranilate synthase XI92_06835 ENOG4105CRQ synthase (Component I) XI92_06845 ENOG4105CK7 Sodium proline symporter XI92_06875 ENOG4108ZMI UPF0477 protein XI92_06925 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase XI92_06935 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase XI92_06940 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) XI92_06960 ENOG4107TVC Glycosyl transferase, family 2 XI92_06980 ENOG4105K64 Glycosyl transferase, family 2 XI92_07000 ENOG4105EMS pseudouridine synthase XI92_07005 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) XI92_07015 ENOG4106EFP UPF0738 protein XI92_07020 ENOG4105MIX Adenylate cyclase XI92_07025 ENOG4108Z18 K06886 hemoglobin XI92_07040 ENOG4105DPN Oligoendopeptidase f XI92_07050 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) XI92_07060 ENOG4108ZCF integral membrane protein XI92_07090 ENOG4108JQ7 (ABC) transporter XI92_07100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component XI92_07105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component XI92_07125 ENOG4105C31 Tryptophanyl-tRNA synthetase XI92_07145 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) XI92_07150 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) XI92_07175 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit XI92_07190 ENOG4108KP7 hydrolase XI92_07200 ENOG41073B9 XI92_07205 ENOG4107AYK membrAne XI92_07215 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) XI92_07230 ENOG4105QNR S1 RNA binding domain protein XI92_07235 ENOG4108VPT UPF0234 protein XI92_07250 ENOG4105BZU Histidine kinase XI92_07290 ENOG4105CH6 catalase XI92_07295 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) XI92_07300 ENOG4105CAQ asparagine synthetase XI92_07325 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase XI92_07330 ENOG4105XSJ toxin secretion phage lysis holin XI92_07400 ENOG41085W3 Transposase XI92_07435 ENOG41085W3 Transposase XI92_07455 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) XI92_07550 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) XI92_07565 ENOG4105CAQ asparagine synthetase XI92_07580 ENOG4105C8Y Acetylornithine aminotransferase XI92_07590 ENOG4105ERH Fumarylacetoacetate hydrolase XI92_07670 ENOG4105VEQ Cold shock protein XI92_07690 ENOG4107QP3 malate synthase g XI92_07700 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) XI92_07705 ENOG4105C8Q Methyl-accepting chemotaxis XI92_07710 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 XI92_07730 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XI92_07745 ENOG41086D8 Transcriptional regulator XI92_07750 ENOG4108AEY RNA polymerase sigma factor XI92_07760 ENOG4107TVP HD domain protein XI92_07765 ENOG4107RN3 metallophosphoesterase XI92_07770 ENOG4105ENX hydrolase XI92_07780 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) XI92_07855 ENOG4108IJ6 ABC transporter XI92_07860 ENOG4105ECW sulfate abc transporter XI92_07865 ENOG4108I5D sulfate abc transporter XI92_07870 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein XI92_07880 ENOG4105CEY Amp-dependent synthetase and ligase XI92_07895 ENOG4105DF9 Lipoate-protein, ligase XI92_07900 ENOG4108RQ5 Beta-lactamase domain-containing protein XI92_07905 ENOG4106AXD XI92_07915 ENOG4108MK9 spermidine N(1)-acetyltransferase XI92_07945 ENOG4105ECB domain protein XI92_07945 ENOG4105ECB domain protein XI92_07960 ENOG4105NA0 Transcriptional regulator XI92_07985 ENOG4105C1Q protoporphyrinogen oxidase XI92_07990 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) XI92_08000 ENOG4105BZ4 penicillin-binding protein XI92_08005 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation XI92_08010 ENOG4105CKV Membrane XI92_08015 ENOG410905X membrane-flanked domain protein XI92_08055 ENOG4105CKV Membrane XI92_08060 ENOG410905X membrane-flanked domain protein XI92_08090 ENOG4105K59 histidine triad (HIT) protein XI92_08120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) XI92_08125 ENOG4105EEM helicase XI92_08130 ENOG4105CNI cell division protein FtsW XI92_08140 ENOG4105EMN RNA polymerase sigma factor XI92_08155 ENOG4105C6V Glycerol-3-phosphate dehydrogenase XI92_08170 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator XI92_08175 ENOG41067QW Transcriptional regulator XI92_08180 ENOG4105F0F Oxalate decarboxylase XI92_08240 ENOG4106D4I domain protein XI92_08245 ENOG4107VRP DNA repair exonuclease XI92_08265 ENOG4107QHE Choloylglycine hydrolase XI92_08275 ENOG4105C6F GntR Family Transcriptional Regulator XI92_08290 ENOG4105K8R UPF0145 protein XI92_08315 ENOG4105BZU Histidine kinase XI92_08320 ENOG4105BZU Histidine kinase XI92_08325 ENOG4108MJI response regulator XI92_08335 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XI92_08345 ENOG4105WN5 stage II sporulation protein XI92_08455 ENOG4105CMT Dihydroxyacetone kinase XI92_08465 ENOG4105CMT Dihydroxyacetone kinase XI92_08470 ENOG4108NIW Leucine export protein LeuE XI92_08490 ENOG4105WAB arsR family transcriptional regulator XI92_08495 ENOG4105F27 Major Facilitator XI92_08500 ENOG4105DQ6 Transposase XI92_08515 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase XI92_08570 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) XI92_08590 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein XI92_08620 ENOG4105F6J Alpha beta hydrolase fold XI92_08635 ENOG4105EKQ RNA-directed DNA polymerase XI92_08660 ENOG4107VUZ XI92_08705 ENOG4105DQ6 Transposase XI92_08735 ENOG4105C0R drug resistance transporter emrb qaca subfamily XI92_08745 ENOG41087YS Phage shock protein A XI92_08760 ENOG4108Z86 Glutamine amidotransferase XI92_08785 ENOG4105CDU Replicative dna helicase XI92_08800 ENOG4105CDU Replicative dna helicase XI92_08815 ENOG4105M6F mutator MutT protein XI92_08825 ENOG4108MRH transcriptional regulatory protein XI92_08835 ENOG4105CSH Transporter XI92_08890 ENOG4108IBT Inherit from COG: transposase XI92_08915 ENOG4105DQ6 Transposase XI92_08950 ENOG4108JQ7 (ABC) transporter XI92_08960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component XI92_09005 ENOG4105DER m42 family XI92_09025 ENOG4105CGU Enoyl-CoA hydratase XI92_09050 ENOG4105CHH sulfate transporter XI92_09065 ENOG4105CEY Amp-dependent synthetase and ligase XI92_09070 ENOG4105D4P Coproporphyrinogen iii oxidase XI92_09075 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase XI92_09090 ENOG4108VX5 3-methyladenine DNA glycosylase XI92_09100 ENOG4107FQX Alpha-acetolactate decarboxylase XI92_09135 ENOG410839P XI92_09150 ENOG4105CDA abc transporter atp-binding protein XI92_09155 ENOG4105DRP amino acid AbC transporter XI92_09165 ENOG4105BZ1 (ABC) transporter XI92_09170 ENOG4105BZ1 (ABC) transporter XI92_09180 ENOG4105C26 Dehydrogenase XI92_09190 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) XI92_09195 ENOG4105D5Q Arginine ornithine antiporter XI92_09205 ENOG4105CH6 catalase XI92_09210 ENOG4107RKG DJ-1/PfpI family XI92_09220 ENOG4105E5W Transporter XI92_09225 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) XI92_09260 ENOG4105KPY Small multidrug resistance protein XI92_09270 ENOG4105UBK short-chain dehydrogenase reductase XI92_09275 ENOG4105CH7 arginosuccinase XI92_09280 ENOG4108YXU transcriptional regulator AsnC family XI92_09320 ENOG4106KNT transcriptional regulator XI92_09330 ENOG4107RWR Sodium hydrogen exchanger XI92_09335 ENOG4105CUB amino acid XI92_09370 ENOG4107T5V SNARE associated Golgi XI92_09405 ENOG4105WEF catalase XI92_09435 ENOG4105C19 ABC transporter XI92_09440 ENOG4107RBB ABC transporter, permease XI92_09445 ENOG41069ER domain protein XI92_09470 ENOG4105VZJ PTS System XI92_09475 ENOG4105VCP PTS System XI92_09480 ENOG4105EMD TRANSCRIPTIONal XI92_09505 ENOG4108KGH TRANSCRIPTIONal XI92_09515 ENOG41087NI Sulfite exporter TauE/SafE XI92_09520 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase XI92_09535 ENOG4105VFE sira family XI92_09540 ENOG4107TPS domain protein XI92_09545 ENOG4105VFE sira family XI92_09550 ENOG4105XTG Pfam:DUF156 XI92_09555 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase XI92_09565 ENOG4108TCS Glutamyl endopeptidase XI92_09575 ENOG4105ED1 spovr family XI92_09580 ENOG4107Y03 Nitroreductase XI92_09595 ENOG4105DQ6 Transposase XI92_09610 ENOG4108B31 Spore germination protein XI92_09630 ENOG4105K63 Thioredoxin XI92_09645 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein XI92_09655 ENOG4105C7N Xanthine uracil vitamin C permease XI92_09665 ENOG4105C19 ABC transporter XI92_09740 ENOG4105DWF phosphomethylpyrimidine kinase XI92_09745 ENOG4105D06 uba thif-type nad fad binding protein XI92_09760 ENOG41080HI glycine oxidase XI92_09765 ENOG4108VEU Thiamine monophosphate synthase XI92_09775 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component XI92_09785 ENOG4105ETU transcriptional activator (TenA XI92_09810 ENOG41080XQ Signal transduction protein with cbs domains XI92_09935 ENOG4105E2Z phosphate ABC transporter (Permease XI92_09940 ENOG4105C8U phosphate abc transporter XI92_09945 ENOG4105CVA phosphate XI92_09950 ENOG4105CE1 Ferrous iron transport protein b XI92_09955 ENOG4105CE1 Ferrous iron transport protein b XI92_09960 ENOG4105CE1 Ferrous iron transport protein b XI92_09970 ENOG4108NHD germination protein XI92_09985 ENOG4105E1V na solute symporter XI92_09990 ENOG4106CAD Protein of unknown function (DUF3311) XI92_10010 ENOG4105E2S oxidase) subunit II XI92_10015 ENOG4105BZ9 Cytochrome C oxidase, subunit I XI92_10020 ENOG4105CCU oxidase (Subunit III) XI92_10040 ENOG4105MA6 gCN5-related N-acetyltransferase XI92_10055 ENOG4105C7N Xanthine uracil vitamin C permease XI92_10060 ENOG4105C85 amino acid XI92_10080 ENOG4105DUX Transporter XI92_10095 ENOG4107D63 XI92_10100 ENOG4105VZ8 Transcriptional regulator XI92_10105 ENOG41069ER domain protein XI92_10110 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer XI92_10115 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) XI92_10155 ENOG4105CNU cell division protein FtsK XI92_10245 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) XI92_10255 ENOG4105CAR Terminase, large subunit XI92_10395 ENOG4108IMY Transcriptional regulator XI92_10410 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) XI92_10425 ENOG4105DQ6 Transposase XI92_10460 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) XI92_10465 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator XI92_10470 ENOG4105CNN ABC, transporter XI92_10475 ENOG4105C2J ABC transporter XI92_10485 ENOG4108RVA ribokinase XI92_10490 ENOG4105ETE Transcriptional regulator (LacI family XI92_10495 ENOG4105C0R drug resistance transporter emrb qaca subfamily XI92_10500 ENOG41067TZ transcriptional regulator, MarR family XI92_10505 ENOG4105CXY transporter XI92_10515 ENOG41068KF Universal stress protein XI92_10535 ENOG4105BZU Histidine kinase XI92_10545 ENOG4105D29 Helix-turn-helix type 11 domain protein XI92_10555 ENOG4105GFR rna polymerase sigma factor XI92_10570 ENOG4108IQI permease XI92_10575 ENOG4105DRP amino acid AbC transporter XI92_10580 ENOG4105EAD ABC transporter XI92_10585 ENOG4105CT1 (ABC) transporter XI92_10590 ENOG4105CDA abc transporter atp-binding protein XI92_10600 ENOG4105BZG amino acid carrier protein XI92_10605 ENOG4105CRN Aminoglycoside phosphotransferase XI92_10610 ENOG4105E1K spore germination protein XI92_10625 ENOG4105CG3 alpha amylase, catalytic region XI92_10630 ENOG4105C5Y PTS System XI92_10635 ENOG4107414 GntR family transcriptional regulator XI92_10640 ENOG4105D5Q Arginine ornithine antiporter XI92_10645 ENOG4105BZU Histidine kinase XI92_10655 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) XI92_10660 ENOG4105GMT ATPase associated with various cellular activities aaa_5 XI92_10665 ENOG4107T89 von Willebrand factor, type A XI92_10675 ENOG4105EXW epimerase dehydratase XI92_10680 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) XI92_10685 ENOG4105DMQ Methyltransferase XI92_10690 ENOG4105E0A ABC, transporter XI92_10695 ENOG4108IHU transport system permease protein XI92_10700 ENOG4105DQ5 transport system permease protein XI92_10705 ENOG4108MES Periplasmic binding protein XI92_10710 ENOG4105DUX Transporter XI92_10735 ENOG4105DAA L-lactate XI92_10740 ENOG4108IJ0 Aspartate ammonia-lyase XI92_10745 ENOG4105C37 (CBS) domain XI92_10750 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase XI92_10760 ENOG4105EKQ RNA-directed DNA polymerase XI92_10775 ENOG4105D9N nucleoside XI92_10780 ENOG4108KGH TRANSCRIPTIONal XI92_10785 ENOG41073R8 VanW family XI92_10820 ENOG4105DAP Nicotinate phosphoribosyltransferase XI92_10825 ENOG4105C59 p-type ATPase XI92_10840 ENOG4105CUB amino acid XI92_10860 ENOG4108JB9 formate dehydrogenase XI92_10865 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) XI92_10870 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) XI92_10885 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_10890 ENOG4105BZU Histidine kinase XI92_10900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family XI92_10905 ENOG4108UZ3 Transporter XI92_10915 ENOG4105C6K Malic enzyme XI92_10925 ENOG4108MRH transcriptional regulatory protein XI92_10950 ENOG4105US7 Histidine kinase XI92_10955 ENOG4108STX response regulator XI92_10960 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) XI92_10965 ENOG4105BZ7 extracellular solute-binding protein family 1 XI92_10970 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component XI92_10975 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component XI92_10980 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) XI92_10985 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator XI92_11010 ENOG4105D4T Citrate transporter XI92_11015 ENOG4108V9W transcriptional regulatory protein XI92_11020 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism XI92_11030 ENOG4105DZ6 Band 7 protein XI92_11045 ENOG4105C94 Transporter XI92_11065 ENOG4105CYN Serine protein kinase XI92_11090 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) XI92_11100 ENOG4108R9S DSBA oxidoreductase XI92_11105 ENOG4108JQC penicillin-binding protein 1A XI92_11115 ENOG4105CDY transcriptional regulatory protein XI92_11225 ENOG4105G5W regulator Fur family XI92_11230 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen XI92_11250 ENOG4108IUW ABC transporter XI92_11260 ENOG4105CBC glutamate synthase XI92_11265 ENOG4107NBY Membrane XI92_11270 ENOG4105BZ1 (ABC) transporter XI92_11290 ENOG4106BXE XI92_11295 ENOG4105CEN a g-specific adenine glycosylase XI92_11300 ENOG41067AE Membrane-bound metal-dependent hydrolase XI92_11330 ENOG4105ECP epimerase XI92_11335 ENOG4105CI2 imidazolone-5-propionate hydrolase XI92_11350 ENOG4108QBV Monogalactosyldiacylglycerol synthase XI92_11355 ENOG4105F1A Pyruvate formate-lyase XI92_11375 ENOG4105C3I Nad-dependent epimerase dehydratase XI92_11380 ENOG4107QQG Dehydrogenase XI92_11385 ENOG4105CKK Glycosyl transferase, family 2 XI92_11400 ENOG4108A04 Beta-lactamase XI92_11445 ENOG4108IQI permease XI92_11455 ENOG4108JUB Transcriptional regulator XI92_11465 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) XI92_11470 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) XI92_11505 ENOG4105UPD Calcium Proton XI92_11510 ENOG410606W general stress protein XI92_11525 ENOG4107ZTW SNARE associated Golgi XI92_11550 ENOG4105C59 p-type ATPase XI92_11555 ENOG4107U9T Pfam:Ribonuclease_BN XI92_11565 ENOG4105KJF protein tyrosine phosphatase XI92_11570 ENOG41068PA UPF0435 protein XI92_11585 ENOG4108TTB tellurium resistance protein XI92_11590 ENOG4107TS3 membrane protein, TerC XI92_11595 ENOG4106FN3 tellurium resistance protein XI92_11600 ENOG4106FN3 tellurium resistance protein XI92_11605 ENOG4108N0M stress protein XI92_11620 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) XI92_11635 ENOG4105DEU major facilitator superfamily XI92_11650 ENOG41062JF Transcriptional regulator XI92_11690 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component XI92_11710 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter XI92_11725 ENOG4105C9U ATP-dependent DNA helicase RecQ XI92_11740 ENOG4105CI1 PTS System XI92_11770 ENOG4108W63 CRP FNR family transcriptional regulator XI92_11775 ENOG4105C5B carbamate kinase XI92_11785 ENOG4105DBV ornithine carbamoyltransferase XI92_11800 ENOG4105C8Q Methyl-accepting chemotaxis XI92_11810 ENOG4105EAB amino acid AbC transporter XI92_11815 ENOG4105E5Q amino acid AbC transporter XI92_11840 ENOG4105D2S major facilitator superfamily XI92_11865 ENOG4105BZU Histidine kinase XI92_11880 ENOG4106UIA XI92_11885 ENOG4106UIA XI92_11905 ENOG4105CAY ferredoxin--nadp reductase XI92_11915 ENOG4108V5C ABC transporter XI92_11920 ENOG4105DQ5 transport system permease protein XI92_11925 ENOG4105EHG Permease protein XI92_11930 ENOG4107W7X Aldolase XI92_11935 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) XI92_11940 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) XI92_11945 ENOG4105D3R alkyl hydroperoxide reductase XI92_11975 ENOG4105DTQ mandelate racemase muconate lactonizing XI92_11990 ENOG4108W15 Protein of unknown function (DUF1456) XI92_12000 ENOG4108FPN Integrase XI92_12005 ENOG4108KU9 integrase family XI92_12020 ENOG4107TSN permease XI92_12105 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) XI92_12110 ENOG41085W3 Transposase XI92_12120 ENOG4105CAR Terminase, large subunit XI92_12255 ENOG4105KRN Transcriptional regulator, abrb family XI92_12265 ENOG4106CVF DNA replication protein XI92_12310 ENOG4105VTR Integrase XI92_12315 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) XI92_12320 ENOG4105D9N nucleoside XI92_12345 ENOG4105KPY Small multidrug resistance protein XI92_12350 ENOG4105C26 Dehydrogenase XI92_12360 ENOG4108JPW Aminotransferase XI92_12365 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) XI92_12370 ENOG4105CBD Diacylglycerol kinase XI92_12390 ENOG4107I77 yiaA/B two helix domain XI92_12395 ENOG410834F Transcriptional regulator XI92_12415 ENOG4105D01 (LipO)protein XI92_12420 ENOG4108UMI ABC transporter, permease XI92_12425 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) XI92_12430 ENOG4108W2Y isochorismatase XI92_12455 ENOG4105C4R Atp-dependent dna helicase XI92_12485 ENOG4105C12 Phosphoribosylglycinamide synthetase XI92_12495 ENOG4108V3E phosphoribosylglycinamide formyltransferase XI92_12520 ENOG4105VR9 phosphoribosylformylglycinamidine synthase XI92_12530 ENOG4105C83 adenylosuccinate lyase XI92_12535 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit XI92_12540 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) XI92_12575 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) XI92_12625 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XI92_12670 ENOG4107ZXU DSBA oxidoreductase XI92_12695 ENOG4105BZU Histidine kinase XI92_12705 ENOG4105C7N Xanthine uracil vitamin C permease XI92_12715 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) XI92_12740 ENOG4105XSJ toxin secretion phage lysis holin XI92_12975 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) XI92_13070 ENOG4108TYN CAAX amino terminal protease family protein XI92_13085 ENOG4105C5H ABC transporter XI92_13090 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) XI92_13095 ENOG410801F ribosomal-protein-alanine acetyltransferase XI92_13100 ENOG41072GX Peptidase M22 Glycoprotease XI92_13105 ENOG4105K8N protein family UPF0079, ATPase XI92_13210 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) XI92_13220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) XI92_13225 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein XI92_13250 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) XI92_13255 ENOG4105CPF Cell wall formation (By similarity) XI92_13260 ENOG4108SC4 )-transporter XI92_13275 ENOG4105ERH Fumarylacetoacetate hydrolase XI92_13280 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase XI92_13310 ENOG410667J hydrolase XI92_13320 ENOG4105DQ6 Transposase XI92_13325 ENOG4108JQ7 (ABC) transporter XI92_13330 ENOG4105C3U ABC transporter XI92_13335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component XI92_13350 ENOG4105EKQ RNA-directed DNA polymerase XI92_13370 ENOG4105DEF Extracellular solute-binding protein, family 5 XI92_13380 ENOG4105C5H ABC transporter XI92_13405 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) XI92_13425 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) XI92_13445 ENOG4105F6E Acyl-transferase XI92_13465 ENOG4105EGI Transcriptional regulator XI92_13480 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family XI92_13485 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein XI92_13490 ENOG4105E0C molybdate abc transporter XI92_13515 ENOG4108J59 Extracellular solute-binding protein, family 5 XI92_13520 ENOG4108J59 Extracellular solute-binding protein, family 5 XI92_13550 ENOG4105C2C drug resistance transporter, Bcr CflA XI92_13565 ENOG4105IQ5 FAD linked oxidase domain protein XI92_13575 ENOG4105CB2 alcohol dehydrogenase XI92_13580 ENOG4105D01 (LipO)protein XI92_13585 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) XI92_13590 ENOG4108UMI ABC transporter, permease XI92_13595 ENOG4108PSK reductase XI92_13615 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) XI92_13630 ENOG4107U5W ybbr family XI92_13715 ENOG4108NMV polysaccharide deacetylase XI92_13730 ENOG4105D1F ATP-binding protein XI92_13755 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) XI92_13760 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) XI92_13765 ENOG4108JJB ABC transporter XI92_13770 ENOG4108JJB ABC transporter XI92_13795 ENOG41067V7 50S ribosomal protein L36 XI92_13805 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) XI92_13815 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) XI92_13840 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) XI92_13945 ENOG4105XPM ribosomal protein XI92_13960 ENOG4107Y49 methyltransferase XI92_13985 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) XI92_14000 ENOG4105QIV RNA polymerase XI92_14005 ENOG4105M0M Tetracycline resistance protein XI92_14010 ENOG4105C2N RNA methyltransferase TrmH family group 3 XI92_14025 ENOG4105D7W serine acetyltransferase XI92_14040 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) XI92_14045 ENOG4105CTP PilT protein domain protein XI92_14055 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) XI92_14070 ENOG4108Z0C Uvrb UvrC protein XI92_14160 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) XI92_14170 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase XI92_14175 ENOG4105KRF dihydroneopterin aldolase XI92_14180 ENOG4105EEI dihydropteroate synthase XI92_14185 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 XI92_14190 ENOG4105DDQ anthranilate synthase XI92_14195 ENOG4105CRQ synthase (Component I) XI92_14200 ENOG4105C6T cysteine synthase XI92_14215 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) XI92_14220 ENOG4108UGV hypoxanthine phosphoribosyltransferase XI92_14225 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) XI92_14245 ENOG41060GV RNA binding s1 domain protein XI92_14260 ENOG4105VYY sporulation protein yabp XI92_14265 ENOG41082I2 s4 domain protein XI92_14270 ENOG4108IY2 MazG family XI92_14280 ENOG4108M14 stage v sporulation protein t XI92_14285 ENOG4108JA2 transcriptioN-repair coupling factor XI92_14295 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) XI92_14300 ENOG4105C5T Phosphoribosyl pyrophosphate synthase XI92_14305 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) XI92_14315 ENOG4105KME endoribonuclease L-psp XI92_14320 ENOG4105DFT pur operon repressor XI92_14335 ENOG4105W42 Veg protein XI92_14340 ENOG4105XFA sporulation peptidase YabG XI92_14350 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) XI92_14355 ENOG4105F8V Hydrolase, tatD family XI92_14360 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) XI92_14365 ENOG4105KRN Transcriptional regulator, abrb family XI92_14370 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) XI92_14380 ENOG41060K3 Methyltransferase XI92_14390 ENOG4105MA4 psp1 domain protein XI92_14395 ENOG4105FA2 dna polymerase iii XI92_14405 ENOG4105CXN decarboxylase XI92_14440 ENOG41067KS pro-sigma K processing XI92_14460 ENOG4105C6E dna polymerase iii XI92_14465 ENOG4108Z6B deaminase XI92_14475 ENOG4105GTG Isochorismatase XI92_14485 ENOG4105ZMH deoxynucleoside kinase XI92_14520 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) XI92_14555 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) XI92_14570 ENOG410848D S4 domain protein YaaA XI92_14575 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) XI92_14595 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins XI92_14605 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) XI92_14610 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) XI92_14625 ENOG4107QJE Chromosome Partitioning Protein XI92_14630 ENOG4105FA0 parb-like partition protein XI92_14635 ENOG4108ZDA Sporulation protein YyaC XI92_14640 ENOG4105D8X mechanosensitive ion channel XI92_14645 ENOG4105VDK protein, conserved in bacteria XI92_14650 ENOG4105C3G gtp-binding protein XI92_14660 ENOG4108UUM single-stranded DNA-binding protein XI92_14670 ENOG4108XMW Membrane XI92_14675 ENOG4105BZR domain protein XI92_14685 ENOG4105CDU Replicative dna helicase XI92_14690 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis XI92_14715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_14720 ENOG4105BZU Histidine kinase XI92_14735 ENOG4105Q2H domain protein XI92_14740 ENOG4105C0H protease XI92_14755 ENOG4105BZU Histidine kinase XI92_14775 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) XI92_14780 ENOG4105C1J atp-dependent rna helicase XI92_14795 ENOG4105EKQ RNA-directed DNA polymerase XI92_14815 ENOG4108UT2 hemolysin iii XI92_14820 ENOG4105CMR udp-glucose 4-epimerase XI92_14825 ENOG4105IW1 AmiS UreI transporter XI92_14835 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) XI92_14850 ENOG4107RGD Major Facilitator superfamily XI92_14855 ENOG4108HRK Histidine kinase XI92_14860 ENOG4108NEV two component transcriptional regulator, LytTR family XI92_14875 ENOG4106F5Q Membrane XI92_14880 ENOG4105E0X reductase XI92_14890 ENOG41067SE Tetr family transcriptional regulator XI92_14895 ENOG4105C5H ABC transporter XI92_14900 ENOG4105CKK Glycosyl transferase, family 2 XI92_14905 ENOG4105EJV Membrane XI92_14915 ENOG4105K64 Glycosyl transferase, family 2 XI92_14930 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) XI92_14935 ENOG4108S4H thioesterase Superfamily protein XI92_14945 ENOG4106YBV Methyl-accepting chemotaxis XI92_14950 ENOG4105EN6 Membrane XI92_14960 ENOG4105CG5 Glycosyl transferase (Group 1 XI92_14970 ENOG41079KZ Major Facilitator Superfamily XI92_14975 ENOG4105DY9 regulatoR XI92_14980 ENOG4105D22 carbon starvation protein XI92_14985 ENOG4105VCD cytoplasmic protein XI92_14990 ENOG4105BZU Histidine kinase XI92_14995 ENOG4105DWF phosphomethylpyrimidine kinase XI92_15000 ENOG4105BZU Histidine kinase XI92_15005 ENOG4105WH1 Two component transcriptional regulator luxr family XI92_15015 ENOG4108Y4K DNA-binding transcriptional activator XI92_15040 ENOG4105D6E homoserine dehydrogenase XI92_15055 ENOG41090WU lipolytic protein G-D-S-L family XI92_15060 ENOG4105CJ1 ABC, transporter XI92_15065 ENOG4108TU7 Inherit from COG: (ABC) transporter XI92_15075 ENOG4105VCH membrane XI92_15080 ENOG410667J hydrolase XI92_15090 ENOG4107SVH Potassium channel protein XI92_15110 ENOG4108VKI Cell wall hydrolase XI92_15120 ENOG4107UEZ chlorite dismutase XI92_15125 ENOG4108IJ2 phosphate acetyltransferase XI92_15130 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) XI92_15135 ENOG4108VCI transcription factor, rsfa family XI92_15145 ENOG4105DQ5 transport system permease protein XI92_15150 ENOG4105EHG Permease protein XI92_15155 ENOG4105E0A ABC, transporter XI92_15160 ENOG4108MES Periplasmic binding protein XI92_15165 ENOG4105DCI Phosphohydrolase XI92_15170 ENOG41069HH 4-oxalocrotonate tautomerase XI92_15175 ENOG4108Z4T Peptidase M50 XI92_15180 ENOG4108XFG YwhD family XI92_15185 ENOG4105BZ4 penicillin-binding protein XI92_15190 ENOG4108QXE glycerophosphoryl diester phosphodiesterase XI92_15195 ENOG4107SWG transcriptional regulator MERR family XI92_15200 ENOG4105DXB Major Facilitator superfamily XI92_15210 ENOG4105CYW agmatinase XI92_15235 ENOG410684U Domain of unknown function (DUF1934) XI92_15245 ENOG4105EMN RNA polymerase sigma factor XI92_15270 ENOG4105DQ6 Transposase XI92_15275 ENOG4105IIU Aminopeptidase XI92_15285 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) XI92_15290 ENOG4108M15 ABC transporter XI92_15295 ENOG4105KCT ABC transporter XI92_15300 ENOG4105BZU Histidine kinase XI92_15310 ENOG4105D4Y metalloprotease XI92_15325 ENOG4105BZU Histidine kinase XI92_15345 ENOG4105EKQ RNA-directed DNA polymerase XI92_15365 ENOG4105DF6 Fe-S oxidoreductase XI92_15375 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase XI92_15380 ENOG4105C1G acyl-Coa dehydrogenase XI92_15385 ENOG4105C1G acyl-Coa dehydrogenase XI92_15400 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) XI92_15420 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) XI92_15425 ENOG4105CBT Fructose-1,6-bisphosphatase XI92_15430 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) XI92_15440 ENOG4107104 thymidine kinase XI92_15445 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) XI92_15450 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) XI92_15455 ENOG4108ZXQ stage ii sporulation protein r XI92_15465 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) XI92_15485 ENOG4107XC4 flavin reductase domain protein, FMN-binding XI92_15490 ENOG4108VGI doxx family XI92_15505 ENOG4108YZG isomerase XI92_15510 ENOG4108UIC UPF0340 protein XI92_15515 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) XI92_15535 ENOG41062M3 atp synthase XI92_15540 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) XI92_15595 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain XI92_15605 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain XI92_15610 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) XI92_15635 ENOG4105D65 subunit l XI92_15640 ENOG4105C8S subunit m XI92_15645 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) XI92_15650 ENOG4106778 Protein of unknown function (DUF1146) XI92_15670 ENOG4105DY9 regulatoR XI92_15685 ENOG4105FRN stage II sporulation protein XI92_15695 ENOG4105MT0 Sporulation transcriptional regulator spoiiid XI92_15710 ENOG4107YJ4 chain length determinant protein XI92_15715 ENOG4105HTX biosynthesis protein XI92_15720 ENOG4107YJ4 chain length determinant protein XI92_15725 ENOG4108RB3 Capsular polysaccharide biosynthesis protein XI92_15730 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase XI92_15735 ENOG4105D3Q Sugar transferase XI92_15745 ENOG4105K64 Glycosyl transferase, family 2 XI92_15755 ENOG4107STW synthase XI92_15770 ENOG4105C6Y Udp-glucose 6-dehydrogenase XI92_15775 ENOG4105CMR udp-glucose 4-epimerase XI92_15780 ENOG4108KGH TRANSCRIPTIONal XI92_15790 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_15795 ENOG4105BZU Histidine kinase XI92_15810 ENOG4105CXY transporter XI92_15820 ENOG4105C19 ABC transporter XI92_15825 ENOG4107RBB ABC transporter, permease XI92_15835 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XI92_15865 ENOG4105C0D helicase XI92_15870 ENOG4105KBK Zinc finger, swim domain protein XI92_15895 ENOG41069ER domain protein XI92_15900 ENOG4105C94 Transporter XI92_15910 ENOG4107R8N Glycosyl transferase, family 2 XI92_15935 ENOG4105E0M Sulfatase XI92_15945 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) XI92_15955 ENOG4105D7V transposase XI92_15960 ENOG4105DAA L-lactate XI92_15995 ENOG4107RSM transcriptional regulator XI92_16000 ENOG4105ECB domain protein XI92_16020 ENOG4105VZJ PTS System XI92_16030 ENOG4105VCP PTS System XI92_16040 ENOG4105CK1 PTS System XI92_16045 ENOG4105VCP PTS System XI92_16050 ENOG4105F8D glycoside hydrolase family 4 XI92_16070 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family XI92_16080 ENOG4105ESV Glycosyl transferase, family 4 XI92_16085 ENOG4105C6Y Udp-glucose 6-dehydrogenase XI92_16090 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase XI92_16095 ENOG4108KGH TRANSCRIPTIONal XI92_16100 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein XI92_16110 ENOG4105KVH Transcriptional regulator XI92_16125 ENOG41081UC Inherit from COG: Competence protein XI92_16130 ENOG4105VEQ Cold shock protein XI92_16135 ENOG4105MS2 ribosomal subunit Interface protein XI92_16165 ENOG4108RDQ ABC transporter XI92_16180 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) XI92_16195 ENOG4105CAK Cell division ATP-binding protein ftsE XI92_16200 ENOG4105CRP Part of the ABC transporter FtsEX involved in XI92_16205 ENOG4105CN1 protease XI92_16215 ENOG4105BZ1 (ABC) transporter XI92_16230 ENOG4108WS4 fmn reductase XI92_16240 ENOG4105DUM transcriptional regulator, lysR family XI92_16260 ENOG4107TXC Transcriptional regulator XI92_16275 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) XI92_16280 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) XI92_16290 ENOG41086DT Membrane protein of unknown function XI92_16310 ENOG4108S4C acetyltransferase XI92_16320 ENOG4105C3M thioredoxin reductase XI92_16330 ENOG4108Z4K mutator MutT protein XI92_16335 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) XI92_16340 ENOG4105CHW UPF0052 protein XI92_16350 ENOG4105KRI phosphocarrier protein (HPr XI92_16355 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) XI92_16360 ENOG4108QY0 Membrane XI92_16375 ENOG4105CZ3 stage V sporulation protein ad XI92_16380 ENOG41090VF Stage v sporulation protein ac XI92_16400 ENOG4105VTR Integrase XI92_16425 ENOG4106050 phage regulatory protein, rha family XI92_16505 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) XI92_16575 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) XI92_16640 ENOG41085W3 Transposase XI92_16645 ENOG4105XSJ toxin secretion phage lysis holin XI92_16650 ENOG41085W3 Transposase XI92_16655 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase XI92_16690 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XI92_16740 ENOG41067MG lrgb family XI92_16745 ENOG4105XZU Preprotein translocase, subunit SecG XI92_16755 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) XI92_16780 ENOG4105EKQ RNA-directed DNA polymerase XI92_16795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_16810 ENOG4105CM4 permease protein XI92_16815 ENOG4108IPW abc transporter atp-binding protein XI92_16840 ENOG4108VY7 phosphate-starvation-inducible protein PsiE XI92_16845 ENOG4108MK9 spermidine N(1)-acetyltransferase XI92_16850 ENOG4105C5H ABC transporter XI92_16870 ENOG4105WMR Protein CrcB homolog XI92_16875 ENOG4105WMR Protein CrcB homolog XI92_16895 ENOG4105D4A Cell wall formation (By similarity) XI92_16900 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) XI92_16915 ENOG4105KVH Transcriptional regulator XI92_16920 ENOG4105F27 Major Facilitator XI92_16925 ENOG4105CV8 reductase XI92_16940 ENOG4108RYK Nad-dependent epimerase dehydratase XI92_16955 ENOG4105D9N nucleoside XI92_16965 ENOG4105EKQ RNA-directed DNA polymerase XI92_16970 ENOG4105D9N nucleoside XI92_16975 ENOG4105D9N nucleoside XI92_16985 ENOG41090A1 ferritin XI92_16995 ENOG4108URH decarboxylase XI92_17010 ENOG4108RMU ferritin dps family protein XI92_17025 ENOG4105NCW Trka-c domain protein XI92_17030 ENOG4107S91 Sodium hydrogen exchanger XI92_17035 ENOG4107T5V SNARE associated Golgi XI92_17050 ENOG4105C2I pirin domain protein XI92_17055 ENOG4105D4Y metalloprotease XI92_17060 ENOG4105VG1 fes assembly suf system protein XI92_17065 ENOG4105C8Q Methyl-accepting chemotaxis XI92_17080 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) XI92_17095 ENOG4105BZU Histidine kinase XI92_17100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_17105 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein XI92_17115 ENOG4107ZTW SNARE associated Golgi XI92_17150 ENOG4107AYK membrAne XI92_17160 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins XI92_17170 ENOG4107R7I amino acid XI92_17175 ENOG4108SUT Major Facilitator Superfamily XI92_17190 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer XI92_17210 ENOG4105DZ1 carboxypeptidase XI92_17225 ENOG4105CHU acetyl-coa acetyltransferase XI92_17230 ENOG4105C1G acyl-Coa dehydrogenase XI92_17235 ENOG4108W8B Beta-lactamase domain protein XI92_17255 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) XI92_17275 ENOG41080E8 Transcriptional regulator, Spx MgsR family XI92_17300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) XI92_17305 ENOG4108UMI ABC transporter, permease XI92_17310 ENOG4105D01 (LipO)protein XI92_17315 ENOG4105D01 (LipO)protein XI92_17320 ENOG4105C3K feS assembly ATPase SufC XI92_17325 ENOG4105JRK feS assembly protein SufD XI92_17330 ENOG4105C9B Cysteine desulfurase XI92_17335 ENOG4108UNV SUF system FeS assembly protein, NifU family XI92_17340 ENOG4105DIW FeS assembly protein SUFB XI92_17345 ENOG4107R8B 5'-nucleotidase XI92_17350 ENOG4105KZD Domain of unknown function (DUF1805) XI92_17355 ENOG4108YTE sporulation protein YunB XI92_17360 ENOG4105FAA peptidase M23 XI92_17385 ENOG41090T1 Membrane XI92_17390 ENOG4107TXC Transcriptional regulator XI92_17395 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) XI92_17400 ENOG4105MMD transcriptional regulator XI92_17425 ENOG4105CBT Fructose-1,6-bisphosphatase XI92_17440 ENOG4105D4U had-superfamily hydrolase, subfamily iia XI92_17445 ENOG4105DYS nad(p)h dehydrogenase (quinone) XI92_17455 ENOG4105DAX Pfam:DUF2983 XI92_17475 ENOG4108W5N phosphatidylglycerophosphatase a XI92_17490 ENOG41083MR nifu domain-containing protein XI92_17540 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA XI92_17545 ENOG4105C4B ABC transporter, permease XI92_17550 ENOG4108JJA ABC, transporter XI92_17575 ENOG4108YX9 iron--sulfur cluster insertion protein erpA XI92_17580 ENOG4105DQ6 Transposase XI92_17585 ENOG4105IYK transposase XI92_17620 ENOG4108IMY Transcriptional regulator XI92_17760 ENOG4105CAR Terminase, large subunit XI92_17770 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) XI92_17830 ENOG4105XSJ toxin secretion phage lysis holin XI92_17835 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase XI92_17895 ENOG4105EWC Purine nucleoside phosphorylase XI92_17925 ENOG4105CEP NADH dehydrogenase XI92_17940 ENOG41069ER domain protein XI92_17960 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase XI92_17975 ENOG4105KA0 thioesterase Superfamily protein XI92_17980 ENOG4105DQ6 Transposase XI92_17990 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) XI92_18005 ENOG4107R3E Citrate transporter XI92_18015 ENOG4105Y38 Kinase-associated protein B XI92_18030 ENOG4105C87 Aminotransferase class I and II XI92_18040 ENOG4108MUZ hydrolase XI92_18045 ENOG4105C5I Dehydrogenase XI92_18050 ENOG4108ZB6 transcriptional regulator AsnC family XI92_18055 ENOG4105CHM Aminotransferase XI92_18065 ENOG4105WG9 Conserved Protein XI92_18085 ENOG4107PBV potassium channel XI92_18090 ENOG4105KT7 mgtC SapB transporter XI92_18125 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation XI92_18220 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) XI92_18240 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) XI92_18285 ENOG4105VEQ Cold shock protein XI92_18295 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase XI92_18300 ENOG4105E4F Isochorismate synthase XI92_18310 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) XI92_18315 ENOG4108IPT Naphthoate synthase XI92_18335 ENOG4105DTQ mandelate racemase muconate lactonizing XI92_18355 ENOG41069H0 dihydroorotase EC 3.5.2.3 XI92_18375 ENOG4105FDP GntR family transcriptional regulator XI92_18380 ENOG4105DQ6 Transposase XI92_18390 ENOG4105C6Z Gluconate XI92_18440 ENOG41082BM Transcriptional regulator, arsr family XI92_18455 ENOG41086D8 Transcriptional regulator XI92_18460 ENOG4105C19 ABC transporter XI92_18475 ENOG4107ZTW SNARE associated Golgi XI92_18500 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) XI92_18505 ENOG4108UGV hypoxanthine phosphoribosyltransferase XI92_18530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_18535 ENOG4105BZU Histidine kinase XI92_18565 ENOG41087YS Phage shock protein A XI92_18605 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii XI92_18610 ENOG4105C4M (Ubiquinol oxidase) subunit I XI92_18615 ENOG4108V2W Carbonate dehydratase XI92_18675 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component XI92_18685 ENOG4105D2X ABC transporter substrate-binding protein XI92_18705 ENOG4107T7U Sulfatase XI92_18710 ENOG4107S9D Alpha beta hydrolase XI92_18720 ENOG4105BZU Histidine kinase XI92_18725 ENOG4105BZU Histidine kinase XI92_18735 ENOG4105E98 transcriptional regulator DeoR family XI92_18785 ENOG4108MK9 spermidine N(1)-acetyltransferase XI92_18800 ENOG4105EPU Molybdenum cofactor synthesis domain protein XI92_18810 ENOG4105BZF Glycosyl transferase (Group 1 XI92_18815 ENOG4105YVM Phosphoesterase, PA-phosphatase related XI92_18820 ENOG4108Z0R Transferase XI92_18825 ENOG4105E8V Alpha Beta Hydrolase Fold protein XI92_18855 ENOG4105N5T Radical SAM Protein XI92_18875 ENOG4105C19 ABC transporter XI92_18890 ENOG4105NCW Trka-c domain protein XI92_18895 ENOG4107S91 Sodium hydrogen exchanger XI92_18900 ENOG410605W Major Facilitator XI92_18905 ENOG4105C8T Leucyl-tRNA synthetase XI92_18935 ENOG4108B31 Spore germination protein XI92_18960 ENOG41085GJ domain protein XI92_18980 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) XI92_18985 ENOG4105D06 uba thif-type nad fad binding protein XI92_18995 ENOG4105CVM Molybdenum cofactor synthesis domain protein XI92_19000 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein XI92_19005 ENOG4108ZAF Molybdopterin XI92_19020 ENOG4105CSC Glucose uptake protein XI92_19025 ENOG4107EXU Short-chain dehydrogenase reductase Sdr XI92_19030 ENOG4108VJ1 Transcriptional regulator (CarD family XI92_19070 ENOG4105CBX hi0933 family XI92_19085 ENOG4105YW5 deoR family transcriptional regulator XI92_19090 ENOG4107QSE Dipeptidase XI92_19100 ENOG4108IUM Glycogen debranching enzyme XI92_19105 ENOG4108V15 phosphotransferase enzyme family XI92_19120 ENOG4105C8F Beta-lactamase domain protein XI92_19150 ENOG4108VDD TRNA binding domain protein XI92_19195 ENOG4105C88 aminopeptidase XI92_19215 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase XI92_19225 ENOG4105ETE Transcriptional regulator (LacI family XI92_19255 ENOG4105EP9 oxidoreductase XI92_19260 ENOG4105DY9 regulatoR XI92_19285 ENOG4107SNB ankyrin repeat protein YahD XI92_19295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XI92_19310 ENOG4105DGU Histone deacetylase XI92_19315 ENOG4105W87 Cbs domain XI92_19320 ENOG4105F1V Acetoin utilization protein XI92_19330 ENOG4108UW5 maltose o-acetyltransferase XI92_19340 ENOG4105EMN RNA polymerase sigma factor XI92_19380 ENOG4105C28 cystathionine XI92_19390 ENOG4105U5Y Transcriptional regulator XI92_19400 ENOG4105RQF LysR family Transcriptional regulator XI92_19425 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) XI92_19435 ENOG4105EFZ amidohydrolase XI92_19450 ENOG4105KBJ sporulation protein ytfj XI92_19455 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) XI92_19465 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) XI92_19485 ENOG4108JYZ YitT family XI92_19530 ENOG4107YZX Universal stress protein XI92_19550 ENOG41082W1 Cupin 2, conserved barrel domain protein XI92_19585 ENOG4105DC7 peptidase M24 XI92_19590 ENOG4105E8R UPF0173 metal-dependent hydrolase XI92_19615 ENOG4105SFS phosphoesterase RecJ domain protein XI92_19625 ENOG4105VV2 XI92_19630 ENOG4105C0B DNA polymerase III (alpha subunit) XI92_19635 ENOG4105C6K Malic enzyme XI92_19640 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family XI92_19665 ENOG4105FS0 cytoplasmic membrane protein XI92_19670 ENOG4108REF Sporulation integral membrane protein ytvi XI92_19685 ENOG4105BZN citrate synthase XI92_19690 ENOG4108HMX isocitrate dehydrogenase (NADP) XI92_19710 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XI92_19715 ENOG4105BZU Histidine kinase XI92_19720 ENOG4105C2M dna polymerase I XI92_19725 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) XI92_19735 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) XI92_19740 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase XI92_19745 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) XI92_19770 ENOG4108TDW sporulation protein YtxC XI92_19775 ENOG4105C22 threonyL-tRNA synthetase XI92_19780 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) XI92_19800 ENOG4105CN9 Peptidase m42 family protein XI92_19805 ENOG4108JGH Tetr family transcriptional regulator XI92_19810 ENOG4105CW7 secretion protein, HlyD family XI92_19815 ENOG4105C0R drug resistance transporter emrb qaca subfamily XI92_19845 ENOG4108RWN rrna methyltransferase XI92_19855 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) XI92_19860 ENOG4105C5S asparaginyl-tRNA synthetase XI92_19880 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) XI92_19895 ENOG4105DCG PHP domain protein XI92_19910 ENOG4105FE9 pseudouridine synthase XI92_19920 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) XI92_19930 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) XI92_19945 ENOG4105E0A ABC, transporter XI92_19950 ENOG4105KFN sortase, SrtB family XI92_19960 ENOG4105DR4 Methyltransferase XI92_19975 ENOG4105DPZ Two component transcriptional regulator (Winged helix family XI92_20030 ENOG4105J76 Periplasmic binding protein XI92_20040 ENOG4105CEY Amp-dependent synthetase and ligase XI92_20045 ENOG4107Z3H Transcriptional regulator, TetR family XI92_20050 ENOG41060WC Enoyl-CoA hydratase XI92_20055 ENOG4105BZJ Electron transfer flavoprotein XI92_20060 ENOG4105C10 Electron transfer flavoprotein XI92_20065 ENOG4105K63 Thioredoxin XI92_20070 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) XI92_20080 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit XI92_20090 ENOG4105E33 succinate dehydrogenase XI92_20100 ENOG4108VXD carboxy-peptidase XI92_20105 ENOG4105E14 MotA TolQ exbB proton channel XI92_20110 ENOG4105ER2 Ompa motb domain protein XI92_20115 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family XI92_20120 ENOG4108IUX (ABC) transporter XI92_20125 ENOG4105RHA ABC transporter, permease XI92_20130 ENOG4108Z40 Transcriptional regulator XI92_20135 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) XI92_20145 ENOG4108JCI Transcriptional regulator XI92_20150 ENOG41067S9 phage shock protein C, PspC XI92_20155 ENOG4105DZC cytosine deaminase XI92_20165 ENOG4105PFC Transcriptional regulator XI92_20185 ENOG4108XJQ germination protein XI92_20195 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) XI92_20200 ENOG4105M59 Phosphodiesterase, mj0936 family XI92_20220 ENOG4108QCI YvbH-like oligomerisation region XI92_20245 ENOG4108IUQ atp-dependent protease XI92_20265 ENOG4105K56 Transcriptional regulator XI92_20290 ENOG4105D52 delta-aminolevulinic acid dehydratase XI92_20300 ENOG41068KH stage VI sporulation protein D XI92_20310 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) XI92_20315 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase XI92_20335 ENOG4105DFF Rod shape-determining protein mreb XI92_20340 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) XI92_20355 ENOG4107QMS site-determining protein XI92_20370 ENOG4105C03 ribonuclease XI92_20380 ENOG4105X36 (ribosomal) protein XI92_20395 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control XI92_20405 ENOG4105EWM Histidine kinase XI92_20410 ENOG4105C19 ABC transporter XI92_20425 ENOG4105CQC Prephenate dehydratase XI92_20430 ENOG4108RPX mosc domain containing protein XI92_20445 ENOG4108IYU L-aspartate oxidase XI92_20450 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase XI92_20455 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) XI92_20480 ENOG4108HUF Transporter XI92_20495 ENOG41061AI Protein of unknown function (DUF2905) XI92_20510 ENOG4105VIE preprotein translocase, subunit YajC XI92_20520 ENOG4108QG2 Membrane XI92_20525 ENOG4105CKP Polysaccharide Biosynthesis Protein XI92_20535 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) XI92_20540 ENOG41076HS cation diffusion facilitator family transporter XI92_20545 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) XI92_20555 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) XI92_20560 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) XI92_20570 ENOG4105CUT histidyl-tRNA synthetase XI92_20580 ENOG4105CUZ uba thif-type nad fad binding protein XI92_20590 ENOG4108VCI transcription factor, rsfa family XI92_20595 ENOG4105D1H recombination factor protein RarA XI92_20605 ENOG4105C3J Cysteine desulfurase XI92_20610 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) XI92_20620 ENOG4105C7H Helicase, RecD TraA family XI92_20625 ENOG41060CR XI92_20640 ENOG4105C02 permease XI92_20650 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) XI92_20670 ENOG4105HHA aminodeoxychorismate lyase XI92_20675 ENOG4108VQJ O-methyltransferase XI92_20680 ENOG4105XYU peptidase (U32 family) XI92_20685 ENOG4105CFP Peptidase U32 XI92_20695 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) XI92_20705 ENOG4107XRG penicillin-binding protein XI92_20735 ENOG4105C28 cystathionine XI92_20740 ENOG4108EKI Dehydrogenase XI92_20750 ENOG4108V5C ABC transporter XI92_20755 ENOG4105S6R Iron-hydroxamate transporter permease subunit XI92_20795 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase XI92_20805 ENOG4105MIR Phenylalanine 4-monooxygenase XI92_20855 ENOG4108MUZ hydrolase XI92_20860 ENOG4105KEG ribosomal-protein-alanine acetyltransferase XI92_20865 ENOG4105G6Z alkaline phosphatase XI92_20880 ENOG4108TVJ Nitroreductase XI92_20900 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XI92_20915 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase XI92_20920 ENOG4105CQW ribosome biogenesis GTPase YqeH XI92_20930 ENOG410812S Rna-binding protein XI92_20940 ENOG4108WF2 Metal Dependent Phosphohydrolase XI92_20950 ENOG4105DXX methyltransferase XI92_20960 ENOG4105KQC Competence protein XI92_20965 ENOG4108UK2 deaminase XI92_20970 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 XI92_20980 ENOG4105TQK DNA polymerase iii, delta' subunit XI92_21005 ENOG4105KVH Transcriptional regulator XI92_21010 ENOG4105CSA Coproporphyrinogen iii oxidase XI92_21040 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) XI92_21045 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) XI92_21055 ENOG4105KTH gatB Yqey XI92_21080 ENOG4105CTJ Metal Dependent Phosphohydrolase XI92_21090 ENOG4107YR5 Diacylglycerol kinase XI92_21095 ENOG4105KG3 cytidine deaminase XI92_21100 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) XI92_21130 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) XI92_21135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XI92_21150 ENOG4105EGD dinuclear metal center protein, YbgI family XI92_21175 ENOG41069ZM Protein of unknown function (DUF2624) XI92_21180 ENOG4108JYZ YitT family XI92_21185 ENOG4105FDK ABC transporter XI92_21195 ENOG4105N80 Ferric uptake regulator, Fur family XI92_21220 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) XI92_21230 ENOG4107RF6 penicillin-binding protein XI92_21235 ENOG4105EXS phosphate abc transporter XI92_21240 ENOG4105C8U phosphate abc transporter XI92_21245 ENOG4105C8U phosphate abc transporter XI92_21250 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) XI92_21255 ENOG4108UTW Plays a role in the regulation of phosphate uptake XI92_21270 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase XI92_21280 ENOG4105DKQ ROK family XI92_21290 ENOG4105C5X domain protein XI92_21310 ENOG4105C28 cystathionine XI92_21315 ENOG4105C28 cystathionine XI92_21330 ENOG4105C3R Methionine synthase XI92_21335 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) XI92_21455 ENOG4105C0D helicase XI92_21485 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family XI92_21490 ENOG4105CJ1 ABC, transporter XI92_21525 ENOG41080TC multidrug resistance protein XI92_21550 ENOG4105WZW rhodanese family XI92_21555 ENOG41082GG biotin lipoate A B protein ligase XI92_21585 ENOG4107YBY Hydrolase XI92_21595 ENOG4105CBJ Metal-dependent enzyme XI92_21605 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) XI92_21610 ENOG4105DC7 peptidase M24 XI92_21635 ENOG4105CD2 stage iii sporulation protein aa XI92_21640 ENOG4105KR5 Stage iii sporulation protein XI92_21645 ENOG4108CQH stage III sporulation protein AC XI92_21650 ENOG4105KQ4 Stage iii sporulation protein ad XI92_21660 ENOG410644B Stage III sporulation protein af XI92_21685 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase XI92_21690 ENOG4108ZSR alkaline shock protein XI92_21700 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) XI92_21715 ENOG4105CTB Polyprenyl synthetase XI92_21725 ENOG4105DX0 Hemolysin A XI92_21730 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) XI92_21735 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) XI92_21740 ENOG4105S1Z Stage IV sporulation protein B XI92_21750 ENOG4107QQR Sporulation XI92_21765 ENOG4108QXE glycerophosphoryl diester phosphodiesterase XI92_21775 ENOG4108JUB Transcriptional regulator XI92_21790 ENOG4107RDP Dehydrogenase XI92_21810 ENOG4105CPP Dehydrogenase, E1 component XI92_21815 ENOG4105C7S Dehydrogenase XI92_21830 ENOG4108QY0 Membrane XI92_21840 ENOG4105G7B Protein of unknown function (DUF2992) XI92_21850 ENOG4108HW3 (ABC) transporter XI92_21855 ENOG4105E5Q amino acid AbC transporter XI92_21860 ENOG4105CDA abc transporter atp-binding protein XI92_21865 ENOG4108QEG Membrane XI92_21870 ENOG4108VZI ErfK ybiS ycfS ynhG family protein XI92_21885 ENOG4105D9U N-acetyltransferase XI92_21890 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) XI92_21905 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic XI92_21925 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) XI92_21940 ENOG4105EJQ L-serine dehydratase XI92_21945 ENOG4105II7 pyrroline-5-carboxylate reductase XI92_21950 ENOG41069FQ Metallo-beta-lactamase superfamily XI92_21955 ENOG4108IXY short-chain dehydrogenase reductase XI92_21970 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) XI92_21985 ENOG4105DBV ornithine carbamoyltransferase XI92_22010 ENOG4105CGH 5'-nucleotidase XI92_22015 ENOG4105DFD Na H antiporter XI92_22025 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) XI92_22040 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) XI92_22045 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) XI92_22070 ENOG4108R6K riboflavin synthase, subunit alpha XI92_22075 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) XI92_22095 ENOG4108YM7 Gcn5-related n-acetyltransferase XI92_22100 ENOG4105ETE Transcriptional regulator (LacI family XI92_22110 ENOG4107SKW Inherit from COG: Alpha beta hydrolase XI92_22130 ENOG4105RHY Pfam:UPF0157 XI92_22140 ENOG4105CPC Aldo Keto reductase XI92_22160 ENOG4105MZ9 stage II sporulation protein m XI92_22165 ENOG4105I3K Ferric uptake regulator, Fur family XI92_22175 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) XI92_22200 ENOG4105D7N magnesium and cobalt transport protein CorA XI92_22230 ENOG4105DVE abc transporter atp-binding protein XI92_22235 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family XI92_22240 ENOG4105DZ1 carboxypeptidase XI92_22245 ENOG41082AN stage II sporulation protein XI92_22255 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XI92_22280 ENOG41090VF Stage v sporulation protein ac XI92_22285 ENOG4105CZ3 stage V sporulation protein ad XI92_22295 ENOG4105G6R Stage v sporulation protein ae XI92_22305 ENOG4105J7I hydrolase XI92_22310 ENOG4105PTM secreted protein XI92_22355 ENOG4105CE4 GlcNAc 6-P deacetylase XI92_22365 ENOG4105FDP GntR family transcriptional regulator XI92_22375 ENOG4105CID antiterminator XI92_22390 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) XI92_22410 ENOG4105BZU Histidine kinase XI92_22420 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase XI92_22435 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) XI92_22460 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase XI92_22490 ENOG41082BM Transcriptional regulator, arsr family XI92_22495 ENOG4105C26 Dehydrogenase XI92_22520 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) XI92_22540 ENOG4105DTD Dehydrogenase XI92_22545 ENOG4105K7K Transcriptional regulator XI92_22580 ENOG4105CHU acetyl-coa acetyltransferase XI92_22620 ENOG4105CG3 alpha amylase, catalytic region XI92_22630 ENOG4107FKK extracellular solute-binding protein family 1 XI92_22640 ENOG4105EG2 ABC transporter, permease XI92_22645 ENOG4105FKQ transcriptional regulator XI92_22650 ENOG4105CHM Aminotransferase XI92_22660 ENOG4108HGU Histidine kinase XI92_22680 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) XI92_22720 ENOG4105UIN XI92_22730 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) XI92_22745 ENOG4105K6S Short-chain dehydrogenase reductase Sdr XI92_22750 ENOG4105EPM Diguanylate phosphodiesterase XI92_22765 ENOG4107IN1 Protein of unknown function (DUF1797) XI92_22775 ENOG4108XRC Protein of unknown function (DUF458) XI92_22810 ENOG4107ZYR domain protein XI92_22815 ENOG4105CN5 Metallo-Beta-Lactamase XI92_22825 ENOG4108X4Q Hydrolase XI92_22830 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) XI92_22845 ENOG4105CPP Dehydrogenase, E1 component XI92_22890 ENOG4105CXN decarboxylase XI92_22910 ENOG4105ECY inositol monophosphatase XI92_22920 ENOG4105CI3 gtp-binding protein typa XI92_22925 ENOG4105QA2 XI92_22945 ENOG4108IAB Phoh family XI92_22960 ENOG4105CNI cell division protein FtsW XI92_22965 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) XI92_23015 ENOG4106UY4 Inherit from COG: Scp-like extracellular XI92_23030 ENOG4107TB6 phosphoglycerate mutase XI92_23050 ENOG4106H78 methyltransferase XI92_23060 ENOG4105H20 Sporulation integral membrane protein YlbJ XI92_23065 ENOG4105D78 K07001 NTE family protein XI92_23070 ENOG41063PX domain protein XI92_23080 ENOG4105KNH Nucleic acid-binding protein XI92_23105 ENOG41074B2 UPF0747 protein XI92_23120 ENOG4105CJN penicillin-binding protein XI92_23125 ENOG4105CJN penicillin-binding protein XI92_23130 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) XI92_23145 ENOG4105CNI cell division protein FtsW XI92_23150 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) XI92_23155 ENOG4105D4A Cell wall formation (By similarity) XI92_23165 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) XI92_23170 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) XI92_23180 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) XI92_23190 ENOG4105WR5 sporulation protein, YlmC YmxH family XI92_23195 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase XI92_23200 ENOG4105DFA alanine racemase domain protein XI92_23210 ENOG41067XK integral membrane protein XI92_23215 ENOG4105DBK s4 domain protein XI92_23225 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) XI92_23240 ENOG4105C34 Pseudouridine synthase XI92_23260 ENOG4105CD3 dihydroorotase XI92_23270 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain XI92_23275 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) XI92_23290 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) XI92_23320 ENOG4105F23 Fibronectin-binding protein XI92_23330 ENOG4105DSJ YicC domain protein XI92_23350 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase XI92_23355 ENOG4105C25 Primosomal protein n' XI92_23370 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B XI92_23380 ENOG4108ZF3 Phosphatase XI92_23385 ENOG4105D9P serine threonine protein kinase XI92_23390 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) XI92_23395 ENOG4105DJV ribulose-phosphate 3-epimerase XI92_23400 ENOG4105FJ0 thiamine XI92_23415 ENOG4108ZAA Alkaline-shock protein XI92_23420 ENOG4105DP4 dak2 domain fusion protein ylov XI92_23425 ENOG4105CB5 ATP-dependent DNA helicase recG XI92_23440 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase XI92_23445 ENOG4105CHR reductase XI92_23460 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) XI92_23465 ENOG4105EKQ RNA-directed DNA polymerase XI92_23470 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) XI92_23475 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) XI92_23495 ENOG4105VB6 UPF0109 protein XI92_23520 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) XI92_23535 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha XI92_23540 ENOG4105C79 DNA protecting protein DprA XI92_23545 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) XI92_23555 ENOG4108HE4 integrase family XI92_23585 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) XI92_23595 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) XI92_23600 ENOG4105KNE Phosphatidate cytidylyltransferase XI92_23605 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) XI92_23610 ENOG4105DZP Membrane-associated zinc metalloprotease XI92_23620 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) XI92_23630 ENOG4105CHV Transcription elongation factor NusA XI92_23635 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination XI92_23640 ENOG4105VHM ribosomal protein XI92_23650 ENOG4105W7A Protein of unknown function (DUF503) XI92_23665 ENOG4105DTN riboflavin biosynthesis protein ribF XI92_23685 ENOG4105C1V Peptidase, M16 XI92_23695 ENOG4105E35 Dipicolinate synthase subunit A XI92_23700 ENOG4108S0H Dipicolinic acid synthetase, b subunit XI92_23705 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) XI92_23715 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) XI92_23730 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit XI92_23740 ENOG4105CNU cell division protein FtsK XI92_23745 ENOG4105FDP GntR family transcriptional regulator XI92_23750 ENOG4105DIH basic membrane XI92_23755 ENOG4108JQ9 ABC transporter XI92_23760 ENOG4105UIB (ABC) transporter XI92_23780 ENOG4108RKS Short-chain dehydrogenase reductase Sdr XI92_23785 ENOG4105XZV Protein of unknown function (DUF3243) XI92_23800 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase XI92_23820 ENOG4105D48 metallophosphoesterase XI92_23825 ENOG4105MCT stage V sporulation protein S XI92_23830 ENOG4108IGT Dipeptidase XI92_23835 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein XI92_23840 ENOG4105DQU oxidoreductase, subunit beta XI92_23875 ENOG410890F Dynamin family XI92_23880 ENOG4105E0M Sulfatase XI92_23890 ENOG4105F0V Cell wall hydrolase XI92_23900 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C XI92_23905 ENOG4105CS2 ec 3.2.1.21 XI92_23910 ENOG4108S3Y transcriptional regulator XI92_23930 ENOG41067MG lrgb family XI92_23950 ENOG4105C5E polysaccharide biosynthesis protein XI92_23970 ENOG4105BZU Histidine kinase XI92_23995 ENOG4105D03 DNA-3-methyladenine glycosylase II XI92_24000 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) XI92_24025 ENOG4105E0A ABC, transporter XI92_24030 ENOG4105NIV Esterase XI92_24040 ENOG4105VPX protein, conserved in bacteria XI92_24045 ENOG410681U heavy metal transport detoxification protein XI92_24050 ENOG4105C59 p-type ATPase XI92_24060 ENOG4105K70 DNA-binding protein XI92_24065 ENOG4105TMB Formate nitrite transporter XI92_24080 ENOG4105C85 amino acid XI92_24095 ENOG4108SJC Membrane XI92_24100 ENOG4107QW4 alcohol dehydrogenase XI92_24105 ENOG4105E98 transcriptional regulator DeoR family XI92_24110 ENOG4105DE4 1-phosphofructokinase XI92_24115 ENOG4105DM4 PTS System XI92_24120 ENOG41069ER domain protein XI92_24150 ENOG4106F1P AAA ATPase, central domain protein XI92_24160 ENOG4105EN6 Membrane XI92_24165 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) XI92_24170 ENOG4105CXI aluminum resistance protein XI92_24175 ENOG4105KV4 Transcriptional regulator XI92_24180 ENOG4105C5F glutamine synthetase XI92_24185 ENOG4105K7K Transcriptional regulator XI92_24205 ENOG4108SVB resolvase XI92_24225 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic XI92_24230 ENOG4108HW3 (ABC) transporter XI92_24265 ENOG4105BZ1 (ABC) transporter XI92_24270 ENOG4105BZ1 (ABC) transporter XI92_24310 ENOG41067MG lrgb family XI92_24315 ENOG4105VAW lrga family XI92_24320 ENOG4107RSM transcriptional regulator XI92_24345 ENOG4105DQ6 Transposase XI92_24350 ENOG4105IYK transposase XI92_24355 ENOG4105CH2 amidohydrolase XI92_24365 ENOG4107QIV Cytochrome c biogenesis protein XI92_24400 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) XI92_24415 ENOG4105CGP Urocanate hydratase XI92_24425 ENOG4108903 Formimidoylglutamase XI92_24430 ENOG4108VJ1 Transcriptional regulator (CarD family XI92_24440 ENOG4105EKQ RNA-directed DNA polymerase XI92_24450 ENOG4105CBC glutamate synthase XI92_24465 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase XI92_24470 ENOG4105FBA Phospholipase Carboxylesterase XI92_24475 ENOG4105BZU Histidine kinase XI92_24485 ENOG4107AYK membrAne XI92_24525 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) XI92_24545 ENOG4105D9G High-affinity XI92_24570 ENOG4108IMY Transcriptional regulator XI92_24575 ENOG4105CEY Amp-dependent synthetase and ligase XI92_24580 ENOG4107ZYJ bioY protein XI92_24585 ENOG4107F3J Amp-dependent synthetase and ligase XI92_24605 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) XI92_24615 ENOG4105E5W Transporter XI92_24645 ENOG4108I0Z Aconitate hydratase XI92_24650 ENOG4105BZ1 (ABC) transporter XI92_24670 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) XI92_24695 ENOG4105D7V transposase XI92_24705 ENOG4105W8X HesB YadR YfhF-family protein XI92_24710 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) XI92_24715 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase XI92_24725 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_24730 ENOG4105C0H protease XI92_24735 ENOG4105K4P CoA-binding domain protein XI92_24745 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) XI92_24755 ENOG4105D9R oxidoreductase XI92_24775 ENOG4105CIG ABC transporter XI92_24785 ENOG4105EMN RNA polymerase sigma factor XI92_24795 ENOG4108KGH TRANSCRIPTIONal XI92_24850 ENOG4105CUB amino acid XI92_24865 ENOG4105E1K spore germination protein XI92_24875 ENOG4108JB9 formate dehydrogenase XI92_24885 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) XI92_24890 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) XI92_24900 ENOG4105TMB Formate nitrite transporter XI92_24905 ENOG4105D06 uba thif-type nad fad binding protein XI92_24910 ENOG4105CVM Molybdenum cofactor synthesis domain protein XI92_24915 ENOG4108ZAF Molybdopterin XI92_24925 ENOG4105D1F ATP-binding protein XI92_24940 ENOG410696E Membrane XI92_24945 ENOG4105FR1 rard protein XI92_24955 ENOG4105EWU Squalene--hopene cyclase XI92_24965 ENOG4105CHR reductase XI92_24970 ENOG4105C26 Dehydrogenase XI92_24980 ENOG4108IA2 Sodium pantothenate symporter XI92_24995 ENOG4106IQC argininosuccinate lyase XI92_25005 ENOG410904N short-chain dehydrogenase reductase XI92_25025 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) XI92_25050 ENOG4105VEQ Cold shock protein XI92_25070 ENOG4108R1P XI92_25080 ENOG41073R8 VanW family XI92_25085 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase XI92_25095 ENOG4105KT7 mgtC SapB transporter XI92_25105 ENOG4105BZU Histidine kinase XI92_25130 ENOG4105C5H ABC transporter XI92_25215 ENOG4105FAW cDP-glucose 4,6-dehydratase XI92_25220 ENOG4108IAJ Nad-dependent epimerase dehydratase XI92_25255 ENOG4105EKQ RNA-directed DNA polymerase XI92_25285 ENOG4105E1K spore germination protein XI92_25295 ENOG4108M1A Chitin-binding protein XI92_25300 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C XI92_25310 ENOG4105CEP NADH dehydrogenase XI92_25315 ENOG4107TPS domain protein XI92_25325 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase XI92_25350 ENOG4105CQB FAD linked oxidase domain protein XI92_25355 ENOG4105C09 Bile acid XI92_25380 ENOG4105CIS alcohol dehydrogenase XI92_25385 ENOG41082BM Transcriptional regulator, arsr family XI92_25400 ENOG4107VXM glycerophosphoryl diester phosphodiesterase XI92_25425 ENOG4108A04 Beta-lactamase XI92_25455 ENOG4105DPN Oligoendopeptidase f XI92_25460 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase XI92_25465 ENOG4105E5K Alpha-amylase XI92_25470 ENOG4105C98 muts2 protein XI92_25485 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) XI92_25495 ENOG4107V2S Transcriptional regulator XI92_25505 ENOG4107CUJ Protein of unknown function (DUF2690) XI92_25510 ENOG41068WN XI92_25530 ENOG4105NX3 Membrane XI92_25535 ENOG4105DQ5 transport system permease protein XI92_25540 ENOG4105EHG Permease protein XI92_25545 ENOG4108MES Periplasmic binding protein XI92_25550 ENOG4105WCN acetyltransferase XI92_25560 ENOG4107R3E Citrate transporter XI92_25570 ENOG4108TN2 lmbE family XI92_25655 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) XI92_25720 ENOG4108ZJ4 polysaccharide deacetylase XI92_25735 ENOG4105KVH Transcriptional regulator XI92_25740 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein XI92_25750 ENOG4105KNA -acetyltransferase XI92_25765 ENOG4105JAB phenazine biosynthesis protein, phzf family XI92_25805 ENOG4105D9R oxidoreductase XI92_25810 ENOG4108TZY GntR Family Transcriptional Regulator XI92_25835 ENOG4105C44 Serine transporter XI92_25850 ENOG4105KVH Transcriptional regulator XI92_25855 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) XI92_25860 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) XI92_25865 ENOG4108UX3 '-nucleotidase XI92_25870 ENOG4105C8Q Methyl-accepting chemotaxis XI92_25900 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase XI92_25905 ENOG4105CV1 Transketolase (EC 2.2.1.1) XI92_25915 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) XI92_25920 ENOG4105C6Z Gluconate XI92_25925 ENOG4105CMG Carbohydrate kinase XI92_25930 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) XI92_25935 ENOG4105XDF Protein of unknown function (DUF1272) XI92_25940 ENOG4105DDN Pentapeptide repeat-containing protein XI92_25975 ENOG4105FAW cDP-glucose 4,6-dehydratase XI92_25980 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase XI92_25995 ENOG4105C37 (CBS) domain XI92_26025 ENOG4105EV4 Multidrug resistance protein mdtH XI92_26035 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) XI92_26065 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) XI92_26070 ENOG4105C31 Tryptophanyl-tRNA synthetase XI92_26140 ENOG4108PSK reductase XI92_26170 ENOG4108RCM Nitroreductase XI92_26175 ENOG4105KVH Transcriptional regulator XI92_26185 ENOG4108Z66 YbaK ebsC protein XI92_26255 ENOG4105DYS nad(p)h dehydrogenase (quinone) XI92_26265 ENOG4105CRW Short chain fatty acid transporter XI92_26280 ENOG4105CZM Major Facilitator XI92_26285 ENOG4107MII Sugar-specific transcriptional regulator TrmB XI92_26300 ENOG4108ISG Major Facilitator XI92_26310 ENOG4105PNM synthesis protein XI92_26315 ENOG4108VXD carboxy-peptidase XI92_26445 ENOG4108IMY Transcriptional regulator XI92_26460 ENOG4107VMI polysaccharide deacetylase XI92_26465 ENOG4108RZE Tetr family transcriptional regulator XI92_26470 ENOG4105CAQ asparagine synthetase XI92_26505 ENOG4105EJQ L-serine dehydratase XI92_26510 ENOG4105C44 Serine transporter XI92_26535 ENOG4105F6S Spore photoproduct lyase XI92_26545 ENOG4105CVK Glutamate decarboxylase XI92_26560 ENOG4108NHD germination protein XI92_26570 ENOG4105CNI cell division protein FtsW XI92_26580 ENOG4105CJW magnesium transporter XI92_26590 ENOG4107RVG penicillin-binding protein XI92_26605 ENOG4107RF6 penicillin-binding protein XI92_26610 ENOG4107RF6 penicillin-binding protein XI92_26640 ENOG4105CJ1 ABC, transporter XI92_26650 ENOG4107Z3H Transcriptional regulator, TetR family XI92_26665 ENOG4105C1G acyl-Coa dehydrogenase XI92_26670 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase XI92_26675 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit XI92_26680 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase XI92_26685 ENOG4105E39 Enoyl-CoA hydratase XI92_26690 ENOG4107QX3 carboxylase XI92_26695 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) XI92_26720 ENOG41085W3 Transposase XI92_26735 ENOG4105DBI uridine monophosphokinase XI92_26750 ENOG4105DZ1 carboxypeptidase XI92_26770 ENOG4105T9C HD domain XI92_26780 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) XI92_26800 ENOG41075H3 AraC family transcriptional regulator XI92_26845 ENOG4107EXU Short-chain dehydrogenase reductase Sdr XI92_26855 ENOG4105MDS 4-oxalocrotonate tautomerase XI92_26860 ENOG4107V2S Transcriptional regulator XI92_26870 ENOG4105CJ1 ABC, transporter XI92_26905 ENOG4105EFA 4-hydroxyphenylacetate XI92_26930 ENOG4105EKQ RNA-directed DNA polymerase XI92_26950 ENOG410900G Protein of unknown function (DUF421) XI92_26955 ENOG4108V4B ThiJ pfpI XI92_26965 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein XI92_26975 ENOG4105DK7 lysyl-tRNA synthetase XI92_27000 ENOG4105EKQ RNA-directed DNA polymerase XI92_27045 ENOG4105D6E homoserine dehydrogenase XI92_27055 ENOG4105CPF Cell wall formation (By similarity) XI92_27060 ENOG4105ETU transcriptional activator (TenA XI92_27095 ENOG41085W3 Transposase XI92_27155 ENOG410667J hydrolase XI92_27160 ENOG4105BZU Histidine kinase XI92_27165 ENOG4107RF6 penicillin-binding protein XI92_27190 ENOG4108JJB ABC transporter XI92_27200 ENOG4108HGU Histidine kinase XI92_27205 ENOG4105VTR Integrase XI92_27265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_27270 ENOG4105GR3 Histidine kinase XI92_27275 ENOG4105CB2 alcohol dehydrogenase XI92_27280 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase XI92_27285 ENOG4105CJN penicillin-binding protein XI92_27330 ENOG4105F27 Major Facilitator XI92_27335 ENOG4107Y80 Major Facilitator superfamily XI92_27355 ENOG4107VXM glycerophosphoryl diester phosphodiesterase XI92_27375 ENOG4107Y9U Membrane XI92_27395 ENOG4105EGD dinuclear metal center protein, YbgI family XI92_27420 ENOG4105FCD Major Facilitator XI92_27430 ENOG4105E09 nadh pyrophosphatase XI92_27435 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) XI92_27460 ENOG4108XI2 Domain of unknown function (DUF1963) XI92_27485 ENOG4108NRW Phospholipase, patatin family XI92_27490 ENOG4105KWG Pfam:DUF1696 XI92_27500 ENOG4108YYS metal-dependent hydrolase (By similarity) XI92_27515 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) XI92_27525 ENOG4105PKS Excinuclease abc c subunit domain protein XI92_27545 ENOG4107VFR oxidoreductase XI92_27570 ENOG4105U0R haloacid dehalogenase-like hydrolase XI92_27575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_27580 ENOG4105BZU Histidine kinase XI92_27600 ENOG4107WD8 ABC transporter, permease XI92_27615 ENOG4105DY8 decarboxylase XI92_27660 ENOG4108IUM Glycogen debranching enzyme XI92_27670 ENOG4105CGH 5'-nucleotidase XI92_27685 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) XI92_27690 ENOG4105FDR Membrane XI92_27695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family XI92_27750 ENOG4105MSI germination protein ypeb XI92_27780 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) XI92_27785 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) XI92_27790 ENOG4107Z3H Transcriptional regulator, TetR family XI92_27820 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family XI92_27855 ENOG41062ES Transcriptional regulator XI92_27870 ENOG4107QKR Dehydrogenase XI92_27880 ENOG4107RUY (E1 component), alpha subunit XI92_27890 ENOG4105JHE Major Facilitator Superfamily XI92_27910 ENOG4105EKQ RNA-directed DNA polymerase XI92_27925 ENOG4105E1F short-chain dehydrogenase reductase XI92_27930 ENOG4105RHY Pfam:UPF0157 XI92_27970 ENOG4107SQ8 Glycine betaine XI92_27975 ENOG4108IJ7 Glycine betaine XI92_28000 ENOG4105E66 phosphoriboisomerase A XI92_28005 ENOG41082BV acetyltransferase XI92_28010 ENOG4108M1A Chitin-binding protein XI92_28015 ENOG41087PP glycosyltransferase MGT family XI92_28040 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) XI92_28045 ENOG4105MSB protein, conserved in bacteria XI92_28070 ENOG4108Z7F N-acetyltransferase XI92_28090 ENOG4105KEG ribosomal-protein-alanine acetyltransferase XI92_28095 ENOG4105EEM helicase XI92_28105 ENOG41066HZ AIG2-like family XI92_28110 ENOG4105C9U ATP-dependent DNA helicase RecQ XI92_28130 ENOG4105DQ6 Transposase XI92_28150 ENOG4105DQ6 Transposase XI92_28180 ENOG4108M1A Chitin-binding protein XI92_28195 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) XI92_28205 ENOG4105BZG amino acid carrier protein XI92_28210 ENOG4105C26 Dehydrogenase XI92_28215 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) XI92_28220 ENOG4105CTU Proline racemase XI92_28225 ENOG4105CTU Proline racemase XI92_28230 ENOG41080HI glycine oxidase XI92_28240 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein XI92_28270 ENOG4107T5V SNARE associated Golgi XI92_28280 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD XI92_28300 ENOG4105DTQ mandelate racemase muconate lactonizing XI92_28315 ENOG4107SET aldo keto reductase XI92_28350 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) XI92_28355 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) XI92_28360 ENOG4105BZU Histidine kinase XI92_28365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_28395 ENOG4105DPN Oligoendopeptidase f XI92_28400 ENOG4105EPR degv family XI92_28465 ENOG4106K7D Major facilitator family transporter XI92_28485 ENOG4107BMA Transglycosylase associated protein XI92_28500 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) XI92_28535 ENOG4105CHM Aminotransferase XI92_28550 ENOG4108ZMI UPF0477 protein XI92_28565 ENOG4105DVE abc transporter atp-binding protein XI92_28620 ENOG4105C02 permease XI92_28635 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) XI92_28640 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component XI92_28645 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein XI92_28650 ENOG4105D7T ABC transporter XI92_28675 ENOG4108AQF aminoglycoside N(3)-acetyltransferase XI92_28715 ENOG4107VC0 DNA alkylation repair enzyme XI92_28720 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase XI92_28725 ENOG4107VMI polysaccharide deacetylase XI92_28730 ENOG4108ZCF integral membrane protein XI92_28735 ENOG4105E0M Sulfatase XI92_28740 ENOG4105C5H ABC transporter XI92_28755 ENOG4105EYF MMPL domain protein XI92_28760 ENOG41082JN Transcriptional regulator XI92_28785 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase XI92_28790 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase XI92_28830 ENOG41069ER domain protein XI92_28840 ENOG4105DNP FAD linked oxidase domain protein XI92_28860 ENOG4105D4B ABC, transporter XI92_28865 ENOG4105F5R ABC transporter XI92_28870 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane XI92_28880 ENOG4105DKT Transcriptional regulator XI92_28885 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) XI92_28895 ENOG41061GT Aldolase XI92_28910 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) XI92_28940 ENOG4105DQ6 Transposase XI92_28955 ENOG4105II7 pyrroline-5-carboxylate reductase XI92_28965 ENOG4107258 Transcriptional regulator XI92_28980 ENOG4105ECK Fatty Acid Desaturase XI92_28990 ENOG4107RBI VanW family XI92_28995 ENOG4105G6Z alkaline phosphatase XI92_29005 ENOG4105VMP Transcriptional regulator XI92_29025 ENOG41068WN XI92_29060 ENOG4105C7R Atpase associated with various cellular activities aaa_3 XI92_29085 ENOG4105CKK Glycosyl transferase, family 2 XI92_29105 ENOG4105CKK Glycosyl transferase, family 2 XI92_29175 ENOG4105C7R Atpase associated with various cellular activities aaa_3 XI92_29235 ENOG4108IBT Inherit from COG: transposase XI92_29255 ENOG4108TVJ Nitroreductase XI92_29260 ENOG4105FS7 Transcriptional regulator XI92_29275 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) XI92_29280 ENOG4105WEC Molybdate metabolism regulator XI92_29300 ENOG4108DMH HTH_ARAC XI92_29305 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) XI92_29310 ENOG4108XET gCN5-related N-acetyltransferase XI92_29325 ENOG4108PCN EamA-like transporter family XI92_29335 ENOG4107XJU UPF0178 protein XI92_29370 ENOG410635A Membrane XI92_29380 ENOG4108IQI permease XI92_29440 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) XI92_29470 ENOG4105P4J Allophanate hydrolase, subunit 1 XI92_29475 ENOG4107258 Transcriptional regulator XI92_29485 ENOG4106N3A copper homeostasis protein cutc XI92_29490 ENOG4108ZHR arsR family transcriptional regulator XI92_29500 ENOG4105FDT acyl-CoA dehydrogenase XI92_29515 ENOG4105DWD nucleoside recognition domain protein XI92_29525 ENOG4105M18 -acetyltransferase XI92_29545 ENOG4105DQ6 Transposase XI92_29550 ENOG4105IYK transposase XI92_29565 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) XI92_29585 ENOG4107EXU Short-chain dehydrogenase reductase Sdr XI92_29610 ENOG4105E2A Dehydrogenase XI92_29615 ENOG4105BZU Histidine kinase XI92_29680 ENOG4105EKQ RNA-directed DNA polymerase XI92_29690 ENOG4105EKQ RNA-directed DNA polymerase XI92_29695 ENOG4105EKQ RNA-directed DNA polymerase XI92_29835 ENOG4105CID antiterminator XI92_29840 ENOG4105C5Y PTS System XI92_29845 ENOG4105CS2 ec 3.2.1.21 XI92_29880 ENOG41068WN XI92_29920 ENOG4105EKQ RNA-directed DNA polymerase XI92_29925 ENOG4105EKQ RNA-directed DNA polymerase XI92_29935 ENOG4105EKQ RNA-directed DNA polymerase XI92_29980 ENOG41085W3 Transposase XI92_30065 ENOG4105EKQ RNA-directed DNA polymerase XI92_30080 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) XI92_30100 ENOG4105F6J Alpha beta hydrolase fold XI92_30105 ENOG4105DUX Transporter XI92_30145 ENOG4105CEY Amp-dependent synthetase and ligase XI92_30170 ENOG4107Y80 Major Facilitator superfamily XI92_30190 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) XI92_30200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family XI92_30205 ENOG4105BZU Histidine kinase XI92_30225 ENOG4105IYK transposase XI92_30230 ENOG4105DQ6 Transposase XI92_30235 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase XI92_30260 ENOG4105D7V transposase XI92_30275 ENOG4105D7V transposase XI92_30325 ENOG4107EXU Short-chain dehydrogenase reductase Sdr XI92_30335 ENOG4105BZ1 (ABC) transporter XI92_30340 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) XI92_30350 ENOG4105CZV ABC transporter XI92_30400 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase XI92_30430 ENOG4105DQ6 Transposase XI92_30455 ENOG4105BZ1 (ABC) transporter XI92_30475 ENOG41067FT ParB-like nuclease domain XI92_30520 ENOG4105IBP Cyclic peptide transporter XI92_30525 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) XI92_30530 ENOG4105C0W non-ribosomal peptide synthetase XI92_30545 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) XI92_30550 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase XI92_30565 ENOG4105C1G acyl-Coa dehydrogenase XI92_30585 ENOG4105C0W non-ribosomal peptide synthetase XI92_30585 ENOG4105C0W non-ribosomal peptide synthetase XI92_30600 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) XI92_30615 ENOG4107SET aldo keto reductase XI92_30640 ENOG4108IMY Transcriptional regulator XI92_30645 ENOG4108UT6 Transferase hexapeptide repeat containing protein XI92_30655 ENOG4105EKQ RNA-directed DNA polymerase XI92_30700 ENOG4105C4R Atp-dependent dna helicase XI92_30740 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) XI92_30760 ENOG410645S MarR family Transcriptional regulator XI92_30800 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) XI92_30810 ENOG4105K70 DNA-binding protein XI92_30815 ENOG4105D7V transposase XI92_30825 ENOG4107JM4 Tetratricopeptide repeat XI92_30830 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) XI92_30890 ENOG4105CAQ asparagine synthetase XI92_30895 ENOG4108RZE Tetr family transcriptional regulator XI92_30900 ENOG4105D7V transposase XI92_30945 ENOG4108IBT Inherit from COG: transposase XI92_30990 ENOG4105D7V transposase XI92_31005 ENOG4105DQ6 Transposase XI92_31035 ENOG4105D7V transposase XI92_31040 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis XI92_31050 ENOG41085W3 Transposase XI92_31060 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase XI92_31065 ENOG4105DR5 peptidase XI92_31070 ENOG41065S2 pneumococcal vaccine antigen XI92_31100 ENOG4108SHJ s-layer protein XI92_31115 ENOG4105D7V transposase XI92_31120 ENOG4107U9B transcriptional regulator XI92_31125 ENOG4108UMN azlc family XI92_31130 ENOG4105KMT branched-chain amino acid XI92_31160 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) XI92_31165 ENOG4108V2W Carbonate dehydratase XI92_31195 ENOG4108WZA zeta toxin XI92_31200 ENOG4105M6F mutator MutT protein XI92_31205 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) XI92_31215 ENOG4107JM4 Tetratricopeptide repeat XI92_31255 ENOG4105D7V transposase XI92_31345 ENOG4105EKQ RNA-directed DNA polymerase XI92_31500 ENOG4105EKQ RNA-directed DNA polymerase XI92_31565 ENOG4105EKQ RNA-directed DNA polymerase XI92_31575 ENOG4105EKQ RNA-directed DNA polymerase XI92_31585 ENOG4105EKQ RNA-directed DNA polymerase XI92_31630 ENOG4105DHF Membrane XI92_31640 ENOG4108IBT Inherit from COG: transposase XI92_31650 ENOG410780I phosphoprotein phosphatase activity XI92_31675 ENOG4107V2S Transcriptional regulator XI92_31680 ENOG4108WS4 fmn reductase XI92_31725 ENOG4107TSN permease XI92_31740 ENOG4108KU9 integrase family XI92_31745 ENOG4108FPN Integrase XI92_31750 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) XI92_31765 ENOG4105K70 DNA-binding protein XI92_31780 ENOG4105KRN Transcriptional regulator, abrb family XI92_31785 ENOG4108J59 Extracellular solute-binding protein, family 5 XI92_31800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) XI92_31850 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving XI92_31880 ENOG4105E1J oxidoreductase XI92_31890 ENOG4107RT3 EamA-like transporter family XI92_31900 ENOG4105EKQ RNA-directed DNA polymerase XI92_31925 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase XI92_31975 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase XI92_32005 ENOG4105D7V transposase XI92_32015 ENOG4105CHH sulfate transporter XI92_32020 ENOG4107YZX Universal stress protein XI92_32025 ENOG4105CN5 Metallo-Beta-Lactamase XI92_32035 ENOG410900G Protein of unknown function (DUF421) XI92_32045 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein XI92_32100 ENOG4105XSJ toxin secretion phage lysis holin XI92_32140 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) XI92_32155 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase XI92_32160 ENOG4107S91 Sodium hydrogen exchanger XI92_32165 ENOG4105NCW Trka-c domain protein XI92_32170 ENOG4105C8Q Methyl-accepting chemotaxis XI92_32180 ENOG4105D7V transposase XI92_32230 ENOG4105D7V transposase XI92_32240 ENOG4107RSM transcriptional regulator XI92_32245 ENOG4107AYK membrAne XI92_32250 ENOG4105CI2 imidazolone-5-propionate hydrolase XI92_32280 ENOG41082BM Transcriptional regulator, arsr family XI92_32320 ENOG4105D7V transposase XI92_32330 ENOG4105C7F AcnD-accessory protein PrpF XI92_32335 ENOG4105D7V transposase XI92_32365 ENOG4105DQ6 Transposase XI92_32370 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase XI92_32385 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) XI92_32495 ENOG4105EKQ RNA-directed DNA polymerase XI92_32555 ENOG4105FB9 CRISPR-associated protein XI92_32690 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) XI92_32695 ENOG4105VIZ double-strand break repair protein XI92_32730 ENOG4105EKQ RNA-directed DNA polymerase XI92_32740 ENOG4105EKQ RNA-directed DNA polymerase XI92_32745 ENOG4105EKQ RNA-directed DNA polymerase XI92_32865 ENOG4105EKQ RNA-directed DNA polymerase XI92_33125 ENOG4108J59 Extracellular solute-binding protein, family 5 XI92_33155 ENOG4105DQ6 Transposase XI92_33185 ENOG4105C9U ATP-dependent DNA helicase RecQ XI92_33245 ENOG4108TFU terminase (Small subunit) XI92_33345 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase XI92_33400 ENOG4108IMY Transcriptional regulator XI92_33520 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) XI92_33550 ENOG4107JM4 Tetratricopeptide repeat XI92_33560 ENOG4105D0M Protease HtpX homolog XI92_33715 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj XI92_33770 ENOG4107QYX exodeoxyribonuclease v alpha XI92_33810 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein XI92_33820 ENOG410900G Protein of unknown function (DUF421) XI92_34070 ENOG4105DR5 peptidase XI92_34405 ENOG4105CHH sulfate transporter XI92_34415 ENOG410900G Protein of unknown function (DUF421) XI92_34425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein XI92_34475 ENOG4108IBT Inherit from COG: transposase XI92_34550 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) XI92_34600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)