locus-tag class description AQ980_00205 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) AQ980_00300 ENOG4108TYN CAAX amino terminal protease family protein AQ980_00315 ENOG4105C5H ABC transporter AQ980_00320 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AQ980_00325 ENOG410801F ribosomal-protein-alanine acetyltransferase AQ980_00330 ENOG41072GX Peptidase M22 Glycoprotease AQ980_00335 ENOG4105K8N protein family UPF0079, ATPase AQ980_00440 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AQ980_00450 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AQ980_00455 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AQ980_00480 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AQ980_00485 ENOG4105CPF Cell wall formation (By similarity) AQ980_00490 ENOG4108SC4 )-transporter AQ980_00495 ENOG4105CUB amino acid AQ980_00505 ENOG4105ERH Fumarylacetoacetate hydrolase AQ980_00510 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase AQ980_00540 ENOG410667J hydrolase AQ980_00550 ENOG4105DQ6 Transposase AQ980_00555 ENOG4108JQ7 (ABC) transporter AQ980_00560 ENOG4105C3U ABC transporter AQ980_00565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AQ980_00580 ENOG4105EKQ RNA-directed DNA polymerase AQ980_00600 ENOG4105DEF Extracellular solute-binding protein, family 5 AQ980_00610 ENOG4105C5H ABC transporter AQ980_00635 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AQ980_00655 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AQ980_00675 ENOG4105F6E Acyl-transferase AQ980_00695 ENOG4105EGI Transcriptional regulator AQ980_00710 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AQ980_00715 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AQ980_00720 ENOG4105E0C molybdate abc transporter AQ980_00745 ENOG4108J59 Extracellular solute-binding protein, family 5 AQ980_00750 ENOG4108J59 Extracellular solute-binding protein, family 5 AQ980_00780 ENOG4105C2C drug resistance transporter, Bcr CflA AQ980_00795 ENOG4105IQ5 FAD linked oxidase domain protein AQ980_00805 ENOG4105CB2 alcohol dehydrogenase AQ980_00810 ENOG4105D01 (LipO)protein AQ980_00815 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AQ980_00820 ENOG4108UMI ABC transporter, permease AQ980_00825 ENOG4108PSK reductase AQ980_00845 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AQ980_00860 ENOG4107U5W ybbr family AQ980_00865 ENOG4105C8B TIGR00159 family AQ980_00945 ENOG4108NMV polysaccharide deacetylase AQ980_00960 ENOG4105D1F ATP-binding protein AQ980_00985 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AQ980_00990 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AQ980_00995 ENOG4108JJB ABC transporter AQ980_01000 ENOG4108JJB ABC transporter AQ980_01025 ENOG41067V7 50S ribosomal protein L36 AQ980_01035 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AQ980_01045 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AQ980_01070 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AQ980_01175 ENOG4105XPM ribosomal protein AQ980_01190 ENOG4107Y49 methyltransferase AQ980_01215 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AQ980_01230 ENOG4105QIV RNA polymerase AQ980_01235 ENOG4105M0M Tetracycline resistance protein AQ980_01240 ENOG4105C2N RNA methyltransferase TrmH family group 3 AQ980_01255 ENOG4105D7W serine acetyltransferase AQ980_01270 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AQ980_01275 ENOG4105CTP PilT protein domain protein AQ980_01285 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AQ980_01300 ENOG4108Z0C Uvrb UvrC protein AQ980_01390 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AQ980_01400 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AQ980_01405 ENOG4105KRF dihydroneopterin aldolase AQ980_01410 ENOG4105EEI dihydropteroate synthase AQ980_01415 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AQ980_01420 ENOG4105DDQ anthranilate synthase AQ980_01425 ENOG4105CRQ synthase (Component I) AQ980_01430 ENOG4105C6T cysteine synthase AQ980_01445 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AQ980_01450 ENOG4108UGV hypoxanthine phosphoribosyltransferase AQ980_01455 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AQ980_01475 ENOG41060GV RNA binding s1 domain protein AQ980_01490 ENOG4105VYY sporulation protein yabp AQ980_01495 ENOG41082I2 s4 domain protein AQ980_01500 ENOG4108IY2 MazG family AQ980_01510 ENOG4108M14 stage v sporulation protein t AQ980_01515 ENOG4108JA2 transcriptioN-repair coupling factor AQ980_01525 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AQ980_01530 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AQ980_01535 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AQ980_01545 ENOG4105KME endoribonuclease L-psp AQ980_01550 ENOG4105DFT pur operon repressor AQ980_01565 ENOG4105W42 Veg protein AQ980_01570 ENOG4105XFA sporulation peptidase YabG AQ980_01580 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) AQ980_01585 ENOG4105F8V Hydrolase, tatD family AQ980_01590 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AQ980_01595 ENOG4105KRN Transcriptional regulator, abrb family AQ980_01600 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AQ980_01610 ENOG41060K3 Methyltransferase AQ980_01620 ENOG4105MA4 psp1 domain protein AQ980_01625 ENOG4105FA2 dna polymerase iii AQ980_01635 ENOG4105CXN decarboxylase AQ980_01670 ENOG41067KS pro-sigma K processing AQ980_01690 ENOG4105C6E dna polymerase iii AQ980_01695 ENOG4108Z6B deaminase AQ980_01705 ENOG4105GTG Isochorismatase AQ980_01715 ENOG4105ZMH deoxynucleoside kinase AQ980_01750 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AQ980_01785 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AQ980_01800 ENOG410848D S4 domain protein YaaA AQ980_01805 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AQ980_01825 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AQ980_01835 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AQ980_01840 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AQ980_01855 ENOG4107QJE Chromosome Partitioning Protein AQ980_01860 ENOG4105FA0 parb-like partition protein AQ980_01865 ENOG4108ZDA Sporulation protein YyaC AQ980_01870 ENOG4105D8X mechanosensitive ion channel AQ980_01875 ENOG4105VDK protein, conserved in bacteria AQ980_01880 ENOG4105C3G gtp-binding protein AQ980_01890 ENOG4108UUM single-stranded DNA-binding protein AQ980_01900 ENOG4108XMW Membrane AQ980_01905 ENOG4105BZR domain protein AQ980_01915 ENOG4105CDU Replicative dna helicase AQ980_01920 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AQ980_01945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_01950 ENOG4105BZU Histidine kinase AQ980_01965 ENOG4105Q2H domain protein AQ980_01970 ENOG4105C0H protease AQ980_01985 ENOG4105BZU Histidine kinase AQ980_02005 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) AQ980_02010 ENOG4105C1J atp-dependent rna helicase AQ980_02025 ENOG4105EKQ RNA-directed DNA polymerase AQ980_02045 ENOG4108UT2 hemolysin iii AQ980_02050 ENOG4105CMR udp-glucose 4-epimerase AQ980_02055 ENOG4105IW1 AmiS UreI transporter AQ980_02065 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AQ980_02080 ENOG4107RGD Major Facilitator superfamily AQ980_02085 ENOG4108HRK Histidine kinase AQ980_02090 ENOG4108NEV two component transcriptional regulator, LytTR family AQ980_02105 ENOG4106F5Q Membrane AQ980_02110 ENOG4105E0X reductase AQ980_02120 ENOG41067SE Tetr family transcriptional regulator AQ980_02125 ENOG4105C5H ABC transporter AQ980_02130 ENOG4105CKK Glycosyl transferase, family 2 AQ980_02135 ENOG4105EJV Membrane AQ980_02145 ENOG4105K64 Glycosyl transferase, family 2 AQ980_02160 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) AQ980_02165 ENOG4108S4H thioesterase Superfamily protein AQ980_02175 ENOG4106YBV Methyl-accepting chemotaxis AQ980_02180 ENOG4105EN6 Membrane AQ980_02190 ENOG4105CG5 Glycosyl transferase (Group 1 AQ980_02200 ENOG41079KZ Major Facilitator Superfamily AQ980_02205 ENOG4105DY9 regulatoR AQ980_02210 ENOG4105D22 carbon starvation protein AQ980_02215 ENOG4105VCD cytoplasmic protein AQ980_02220 ENOG4105BZU Histidine kinase AQ980_02225 ENOG4105DWF phosphomethylpyrimidine kinase AQ980_02230 ENOG4105BZU Histidine kinase AQ980_02235 ENOG4105WH1 Two component transcriptional regulator luxr family AQ980_02245 ENOG4108Y4K DNA-binding transcriptional activator AQ980_02270 ENOG4105D6E homoserine dehydrogenase AQ980_02285 ENOG41090WU lipolytic protein G-D-S-L family AQ980_02290 ENOG4105CJ1 ABC, transporter AQ980_02295 ENOG4108TU7 Inherit from COG: (ABC) transporter AQ980_02305 ENOG4105VCH membrane AQ980_02310 ENOG410667J hydrolase AQ980_02320 ENOG4107SVH Potassium channel protein AQ980_02340 ENOG4108VKI Cell wall hydrolase AQ980_02350 ENOG4107UEZ chlorite dismutase AQ980_02355 ENOG4108IJ2 phosphate acetyltransferase AQ980_02360 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AQ980_02365 ENOG4108VCI transcription factor, rsfa family AQ980_02375 ENOG4105DQ5 transport system permease protein AQ980_02380 ENOG4105EHG Permease protein AQ980_02385 ENOG4105E0A ABC, transporter AQ980_02390 ENOG4108MES Periplasmic binding protein AQ980_02395 ENOG4105DCI Phosphohydrolase AQ980_02400 ENOG41069HH 4-oxalocrotonate tautomerase AQ980_02405 ENOG4108Z4T Peptidase M50 AQ980_02410 ENOG4108XFG YwhD family AQ980_02415 ENOG4105BZ4 penicillin-binding protein AQ980_02420 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AQ980_02425 ENOG4107SWG transcriptional regulator MERR family AQ980_02430 ENOG4105DXB Major Facilitator superfamily AQ980_02440 ENOG4105CYW agmatinase AQ980_02465 ENOG410684U Domain of unknown function (DUF1934) AQ980_02475 ENOG4105EMN RNA polymerase sigma factor AQ980_02500 ENOG4105DQ6 Transposase AQ980_02505 ENOG4105IIU Aminopeptidase AQ980_02515 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AQ980_02520 ENOG4108M15 ABC transporter AQ980_02525 ENOG4105KCT ABC transporter AQ980_02530 ENOG4105BZU Histidine kinase AQ980_02540 ENOG4105D4Y metalloprotease AQ980_02555 ENOG4105BZU Histidine kinase AQ980_02575 ENOG4105EKQ RNA-directed DNA polymerase AQ980_02595 ENOG4105DF6 Fe-S oxidoreductase AQ980_02605 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AQ980_02610 ENOG4105C1G acyl-Coa dehydrogenase AQ980_02615 ENOG4105C1G acyl-Coa dehydrogenase AQ980_02630 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AQ980_02650 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AQ980_02655 ENOG4105CBT Fructose-1,6-bisphosphatase AQ980_02660 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AQ980_02670 ENOG4107104 thymidine kinase AQ980_02675 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AQ980_02680 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AQ980_02685 ENOG4108ZXQ stage ii sporulation protein r AQ980_02695 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AQ980_02715 ENOG4107XC4 flavin reductase domain protein, FMN-binding AQ980_02720 ENOG4108VGI doxx family AQ980_02735 ENOG4108YZG isomerase AQ980_02740 ENOG4108UIC UPF0340 protein AQ980_02745 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AQ980_02765 ENOG41062M3 atp synthase AQ980_02770 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) AQ980_02825 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AQ980_02835 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain AQ980_02840 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AQ980_02865 ENOG4105D65 subunit l AQ980_02870 ENOG4105C8S subunit m AQ980_02875 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AQ980_02880 ENOG4106778 Protein of unknown function (DUF1146) AQ980_02900 ENOG4105DY9 regulatoR AQ980_02915 ENOG4105FRN stage II sporulation protein AQ980_02925 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AQ980_02940 ENOG4107YJ4 chain length determinant protein AQ980_02945 ENOG4105HTX biosynthesis protein AQ980_02950 ENOG4107YJ4 chain length determinant protein AQ980_02955 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AQ980_02960 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AQ980_02965 ENOG4105D3Q Sugar transferase AQ980_02975 ENOG4105K64 Glycosyl transferase, family 2 AQ980_02985 ENOG4107STW synthase AQ980_03000 ENOG4105C6Y Udp-glucose 6-dehydrogenase AQ980_03005 ENOG4105CMR udp-glucose 4-epimerase AQ980_03010 ENOG4108KGH TRANSCRIPTIONal AQ980_03020 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_03025 ENOG4105BZU Histidine kinase AQ980_03040 ENOG4105CXY transporter AQ980_03050 ENOG4105C19 ABC transporter AQ980_03055 ENOG4107RBB ABC transporter, permease AQ980_03065 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ980_03095 ENOG4105C0D helicase AQ980_03100 ENOG4105KBK Zinc finger, swim domain protein AQ980_03125 ENOG41069ER domain protein AQ980_03130 ENOG4105C94 Transporter AQ980_03140 ENOG4107R8N Glycosyl transferase, family 2 AQ980_03165 ENOG4105E0M Sulfatase AQ980_03175 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) AQ980_03185 ENOG4105D7V transposase AQ980_03190 ENOG4105DAA L-lactate AQ980_03225 ENOG4107RSM transcriptional regulator AQ980_03230 ENOG4105ECB domain protein AQ980_03250 ENOG4105VZJ PTS System AQ980_03260 ENOG4105VCP PTS System AQ980_03270 ENOG4105CK1 PTS System AQ980_03275 ENOG4105VCP PTS System AQ980_03280 ENOG4105F8D glycoside hydrolase family 4 AQ980_03300 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AQ980_03310 ENOG4105ESV Glycosyl transferase, family 4 AQ980_03315 ENOG4105C6Y Udp-glucose 6-dehydrogenase AQ980_03320 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AQ980_03325 ENOG4108KGH TRANSCRIPTIONal AQ980_03330 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AQ980_03340 ENOG4105KVH Transcriptional regulator AQ980_03355 ENOG41081UC Inherit from COG: Competence protein AQ980_03360 ENOG4105VEQ Cold shock protein AQ980_03365 ENOG4105MS2 ribosomal subunit Interface protein AQ980_03395 ENOG4108RDQ ABC transporter AQ980_03410 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AQ980_03425 ENOG4105CAK Cell division ATP-binding protein ftsE AQ980_03430 ENOG4105CRP Part of the ABC transporter FtsEX involved in AQ980_03435 ENOG4105CN1 protease AQ980_03445 ENOG4105BZ1 (ABC) transporter AQ980_03460 ENOG4108WS4 fmn reductase AQ980_03470 ENOG4105DUM transcriptional regulator, lysR family AQ980_03490 ENOG4107TXC Transcriptional regulator AQ980_03505 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AQ980_03510 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AQ980_03520 ENOG41086DT Membrane protein of unknown function AQ980_03540 ENOG4108S4C acetyltransferase AQ980_03550 ENOG4105C3M thioredoxin reductase AQ980_03560 ENOG4108Z4K mutator MutT protein AQ980_03565 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AQ980_03570 ENOG4105CHW UPF0052 protein AQ980_03580 ENOG4105KRI phosphocarrier protein (HPr AQ980_03585 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AQ980_03590 ENOG4108QY0 Membrane AQ980_03605 ENOG4105CZ3 stage V sporulation protein ad AQ980_03610 ENOG41090VF Stage v sporulation protein ac AQ980_03630 ENOG4105VTR Integrase AQ980_03655 ENOG4106050 phage regulatory protein, rha family AQ980_03735 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AQ980_03805 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AQ980_03870 ENOG41085W3 Transposase AQ980_03875 ENOG4105XSJ toxin secretion phage lysis holin AQ980_03880 ENOG41085W3 Transposase AQ980_03885 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AQ980_03920 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ980_03970 ENOG41067MG lrgb family AQ980_03975 ENOG4105XZU Preprotein translocase, subunit SecG AQ980_03985 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AQ980_04010 ENOG4105EKQ RNA-directed DNA polymerase AQ980_04025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_04040 ENOG4105CM4 permease protein AQ980_04045 ENOG4108IPW abc transporter atp-binding protein AQ980_04070 ENOG4108VY7 phosphate-starvation-inducible protein PsiE AQ980_04075 ENOG4108MK9 spermidine N(1)-acetyltransferase AQ980_04080 ENOG4105C5H ABC transporter AQ980_04100 ENOG4105WMR Protein CrcB homolog AQ980_04105 ENOG4105WMR Protein CrcB homolog AQ980_04125 ENOG4105D4A Cell wall formation (By similarity) AQ980_04130 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AQ980_04145 ENOG4105KVH Transcriptional regulator AQ980_04150 ENOG4105F27 Major Facilitator AQ980_04155 ENOG4105CV8 reductase AQ980_04170 ENOG4108RYK Nad-dependent epimerase dehydratase AQ980_04185 ENOG4105D9N nucleoside AQ980_04195 ENOG4105EKQ RNA-directed DNA polymerase AQ980_04200 ENOG4105D9N nucleoside AQ980_04205 ENOG4105D9N nucleoside AQ980_04215 ENOG41090A1 ferritin AQ980_04225 ENOG4108URH decarboxylase AQ980_04240 ENOG4108RMU ferritin dps family protein AQ980_04255 ENOG4105NCW Trka-c domain protein AQ980_04260 ENOG4107S91 Sodium hydrogen exchanger AQ980_04265 ENOG4107T5V SNARE associated Golgi AQ980_04280 ENOG4105C2I pirin domain protein AQ980_04285 ENOG4105D4Y metalloprotease AQ980_04290 ENOG4105VG1 fes assembly suf system protein AQ980_04295 ENOG4105C8Q Methyl-accepting chemotaxis AQ980_04310 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AQ980_04325 ENOG4105BZU Histidine kinase AQ980_04330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_04335 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AQ980_04345 ENOG4107ZTW SNARE associated Golgi AQ980_04380 ENOG4107AYK membrAne AQ980_04390 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins AQ980_04400 ENOG4107R7I amino acid AQ980_04405 ENOG4108SUT Major Facilitator Superfamily AQ980_04420 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AQ980_04440 ENOG4105DZ1 carboxypeptidase AQ980_04455 ENOG4105CHU acetyl-coa acetyltransferase AQ980_04460 ENOG4105C1G acyl-Coa dehydrogenase AQ980_04465 ENOG4108W8B Beta-lactamase domain protein AQ980_04485 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AQ980_04505 ENOG41080E8 Transcriptional regulator, Spx MgsR family AQ980_04530 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AQ980_04535 ENOG4108UMI ABC transporter, permease AQ980_04540 ENOG4105D01 (LipO)protein AQ980_04545 ENOG4105D01 (LipO)protein AQ980_04550 ENOG4105C3K feS assembly ATPase SufC AQ980_04555 ENOG4105JRK feS assembly protein SufD AQ980_04560 ENOG4105C9B Cysteine desulfurase AQ980_04565 ENOG4108UNV SUF system FeS assembly protein, NifU family AQ980_04570 ENOG4105DIW FeS assembly protein SUFB AQ980_04575 ENOG4107R8B 5'-nucleotidase AQ980_04580 ENOG4105KZD Domain of unknown function (DUF1805) AQ980_04585 ENOG4108YTE sporulation protein YunB AQ980_04590 ENOG4105FAA peptidase M23 AQ980_04615 ENOG41090T1 Membrane AQ980_04620 ENOG4107TXC Transcriptional regulator AQ980_04625 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AQ980_04630 ENOG4105MMD transcriptional regulator AQ980_04655 ENOG4105CBT Fructose-1,6-bisphosphatase AQ980_04670 ENOG4105D4U had-superfamily hydrolase, subfamily iia AQ980_04675 ENOG4105DYS nad(p)h dehydrogenase (quinone) AQ980_04685 ENOG4105DAX Pfam:DUF2983 AQ980_04705 ENOG4108W5N phosphatidylglycerophosphatase a AQ980_04720 ENOG41083MR nifu domain-containing protein AQ980_04770 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AQ980_04775 ENOG4105C4B ABC transporter, permease AQ980_04780 ENOG4108JJA ABC, transporter AQ980_04805 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AQ980_04810 ENOG4105DQ6 Transposase AQ980_04815 ENOG4105IYK transposase AQ980_04850 ENOG4108IMY Transcriptional regulator AQ980_04990 ENOG4105CAR Terminase, large subunit AQ980_05000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AQ980_05060 ENOG4105XSJ toxin secretion phage lysis holin AQ980_05065 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AQ980_05125 ENOG4105EWC Purine nucleoside phosphorylase AQ980_05155 ENOG4105CEP NADH dehydrogenase AQ980_05170 ENOG41069ER domain protein AQ980_05190 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AQ980_05205 ENOG4105KA0 thioesterase Superfamily protein AQ980_05210 ENOG4105DQ6 Transposase AQ980_05220 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) AQ980_05235 ENOG4107R3E Citrate transporter AQ980_05245 ENOG4105Y38 Kinase-associated protein B AQ980_05260 ENOG4105C87 Aminotransferase class I and II AQ980_05270 ENOG4108MUZ hydrolase AQ980_05275 ENOG4105C5I Dehydrogenase AQ980_05280 ENOG4108ZB6 transcriptional regulator AsnC family AQ980_05285 ENOG4105CHM Aminotransferase AQ980_05295 ENOG4105WG9 Conserved Protein AQ980_05315 ENOG4107PBV potassium channel AQ980_05320 ENOG4105KT7 mgtC SapB transporter AQ980_05355 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AQ980_05450 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AQ980_05470 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AQ980_05515 ENOG4105VEQ Cold shock protein AQ980_05525 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AQ980_05530 ENOG4105E4F Isochorismate synthase AQ980_05540 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AQ980_05545 ENOG4108IPT Naphthoate synthase AQ980_05565 ENOG4105DTQ mandelate racemase muconate lactonizing AQ980_05585 ENOG41069H0 dihydroorotase EC 3.5.2.3 AQ980_05605 ENOG4105FDP GntR family transcriptional regulator AQ980_05610 ENOG4105DQ6 Transposase AQ980_05620 ENOG4105C6Z Gluconate AQ980_05670 ENOG41082BM Transcriptional regulator, arsr family AQ980_05685 ENOG41086D8 Transcriptional regulator AQ980_05690 ENOG4105C19 ABC transporter AQ980_05705 ENOG4107ZTW SNARE associated Golgi AQ980_05730 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AQ980_05735 ENOG4108UGV hypoxanthine phosphoribosyltransferase AQ980_05760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_05765 ENOG4105BZU Histidine kinase AQ980_05795 ENOG41087YS Phage shock protein A AQ980_05835 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AQ980_05840 ENOG4105C4M (Ubiquinol oxidase) subunit I AQ980_05845 ENOG4108V2W Carbonate dehydratase AQ980_05905 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AQ980_05915 ENOG4105D2X ABC transporter substrate-binding protein AQ980_05935 ENOG4107T7U Sulfatase AQ980_05940 ENOG4107S9D Alpha beta hydrolase AQ980_05950 ENOG4105BZU Histidine kinase AQ980_05955 ENOG4105BZU Histidine kinase AQ980_05965 ENOG4105E98 transcriptional regulator DeoR family AQ980_05970 ENOG4107XGZ Hydrolase AQ980_06015 ENOG4108MK9 spermidine N(1)-acetyltransferase AQ980_06030 ENOG4105EPU Molybdenum cofactor synthesis domain protein AQ980_06040 ENOG4105BZF Glycosyl transferase (Group 1 AQ980_06045 ENOG4105YVM Phosphoesterase, PA-phosphatase related AQ980_06050 ENOG4108Z0R Transferase AQ980_06055 ENOG4105E8V Alpha Beta Hydrolase Fold protein AQ980_06085 ENOG4105N5T Radical SAM Protein AQ980_06105 ENOG4105C19 ABC transporter AQ980_06120 ENOG4105NCW Trka-c domain protein AQ980_06125 ENOG4107S91 Sodium hydrogen exchanger AQ980_06130 ENOG410605W Major Facilitator AQ980_06135 ENOG4105C8T Leucyl-tRNA synthetase AQ980_06165 ENOG4108B31 Spore germination protein AQ980_06175 ENOG4105DWV Homoserine O-trans-acetylase AQ980_06185 ENOG41085GJ domain protein AQ980_06205 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AQ980_06210 ENOG4105D06 uba thif-type nad fad binding protein AQ980_06220 ENOG4105CVM Molybdenum cofactor synthesis domain protein AQ980_06225 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AQ980_06230 ENOG4108ZAF Molybdopterin AQ980_06245 ENOG4105CSC Glucose uptake protein AQ980_06250 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AQ980_06255 ENOG4108VJ1 Transcriptional regulator (CarD family AQ980_06295 ENOG4105CBX hi0933 family AQ980_06310 ENOG4105YW5 deoR family transcriptional regulator AQ980_06315 ENOG4107QSE Dipeptidase AQ980_06325 ENOG4108IUM Glycogen debranching enzyme AQ980_06330 ENOG4108V15 phosphotransferase enzyme family AQ980_06345 ENOG4105C8F Beta-lactamase domain protein AQ980_06375 ENOG4108VDD TRNA binding domain protein AQ980_06420 ENOG4105C88 aminopeptidase AQ980_06440 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AQ980_06450 ENOG4105ETE Transcriptional regulator (LacI family AQ980_06480 ENOG4105EP9 oxidoreductase AQ980_06485 ENOG4105DY9 regulatoR AQ980_06510 ENOG4107SNB ankyrin repeat protein YahD AQ980_06520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ980_06535 ENOG4105DGU Histone deacetylase AQ980_06540 ENOG4105W87 Cbs domain AQ980_06545 ENOG4105F1V Acetoin utilization protein AQ980_06555 ENOG4108UW5 maltose o-acetyltransferase AQ980_06565 ENOG4105EMN RNA polymerase sigma factor AQ980_06605 ENOG4105C28 cystathionine AQ980_06615 ENOG4105U5Y Transcriptional regulator AQ980_06625 ENOG4105RQF LysR family Transcriptional regulator AQ980_06650 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AQ980_06660 ENOG4105EFZ amidohydrolase AQ980_06675 ENOG4105KBJ sporulation protein ytfj AQ980_06680 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AQ980_06690 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AQ980_06710 ENOG4108JYZ YitT family AQ980_06755 ENOG4107YZX Universal stress protein AQ980_06775 ENOG41082W1 Cupin 2, conserved barrel domain protein AQ980_06810 ENOG4105DC7 peptidase M24 AQ980_06815 ENOG4105E8R UPF0173 metal-dependent hydrolase AQ980_06840 ENOG4105SFS phosphoesterase RecJ domain protein AQ980_06850 ENOG4105VV2 AQ980_06855 ENOG4105C0B DNA polymerase III (alpha subunit) AQ980_06860 ENOG4105C6K Malic enzyme AQ980_06865 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AQ980_06890 ENOG4105FS0 cytoplasmic membrane protein AQ980_06895 ENOG4108REF Sporulation integral membrane protein ytvi AQ980_06910 ENOG4105BZN citrate synthase AQ980_06915 ENOG4108HMX isocitrate dehydrogenase (NADP) AQ980_06935 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ980_06940 ENOG4105BZU Histidine kinase AQ980_06945 ENOG4105C2M dna polymerase I AQ980_06950 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AQ980_06960 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AQ980_06965 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AQ980_06970 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AQ980_06995 ENOG4108TDW sporulation protein YtxC AQ980_07000 ENOG4105C22 threonyL-tRNA synthetase AQ980_07005 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AQ980_07025 ENOG4105CN9 Peptidase m42 family protein AQ980_07030 ENOG4108JGH Tetr family transcriptional regulator AQ980_07035 ENOG4105CW7 secretion protein, HlyD family AQ980_07040 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ980_07070 ENOG4108RWN rrna methyltransferase AQ980_07080 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AQ980_07085 ENOG4105C5S asparaginyl-tRNA synthetase AQ980_07105 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AQ980_07120 ENOG4105DCG PHP domain protein AQ980_07135 ENOG4105FE9 pseudouridine synthase AQ980_07145 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) AQ980_07155 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) AQ980_07170 ENOG4105E0A ABC, transporter AQ980_07175 ENOG4105KFN sortase, SrtB family AQ980_07185 ENOG4105DR4 Methyltransferase AQ980_07200 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ980_07255 ENOG4105J76 Periplasmic binding protein AQ980_07265 ENOG4105CEY Amp-dependent synthetase and ligase AQ980_07270 ENOG4107Z3H Transcriptional regulator, TetR family AQ980_07275 ENOG41060WC Enoyl-CoA hydratase AQ980_07280 ENOG4105BZJ Electron transfer flavoprotein AQ980_07285 ENOG4105C10 Electron transfer flavoprotein AQ980_07290 ENOG4105K63 Thioredoxin AQ980_07295 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AQ980_07305 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AQ980_07315 ENOG4105E33 succinate dehydrogenase AQ980_07325 ENOG4108VXD carboxy-peptidase AQ980_07330 ENOG4105E14 MotA TolQ exbB proton channel AQ980_07335 ENOG4105ER2 Ompa motb domain protein AQ980_07340 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family AQ980_07345 ENOG4108IUX (ABC) transporter AQ980_07350 ENOG4105RHA ABC transporter, permease AQ980_07355 ENOG4108Z40 Transcriptional regulator AQ980_07360 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AQ980_07370 ENOG4108JCI Transcriptional regulator AQ980_07375 ENOG41067S9 phage shock protein C, PspC AQ980_07380 ENOG4105DZC cytosine deaminase AQ980_07390 ENOG4105PFC Transcriptional regulator AQ980_07410 ENOG4108XJQ germination protein AQ980_07420 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AQ980_07425 ENOG4105M59 Phosphodiesterase, mj0936 family AQ980_07445 ENOG4108QCI YvbH-like oligomerisation region AQ980_07470 ENOG4108IUQ atp-dependent protease AQ980_07490 ENOG4105K56 Transcriptional regulator AQ980_07515 ENOG4105D52 delta-aminolevulinic acid dehydratase AQ980_07525 ENOG41068KH stage VI sporulation protein D AQ980_07535 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AQ980_07540 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AQ980_07560 ENOG4105DFF Rod shape-determining protein mreb AQ980_07565 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AQ980_07580 ENOG4107QMS site-determining protein AQ980_07595 ENOG4105C03 ribonuclease AQ980_07605 ENOG4105X36 (ribosomal) protein AQ980_07620 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AQ980_07630 ENOG4105EWM Histidine kinase AQ980_07635 ENOG4105C19 ABC transporter AQ980_07650 ENOG4105CQC Prephenate dehydratase AQ980_07655 ENOG4108RPX mosc domain containing protein AQ980_07670 ENOG4108IYU L-aspartate oxidase AQ980_07675 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AQ980_07680 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AQ980_07705 ENOG4108HUF Transporter AQ980_07720 ENOG41061AI Protein of unknown function (DUF2905) AQ980_07735 ENOG4105VIE preprotein translocase, subunit YajC AQ980_07745 ENOG4108QG2 Membrane AQ980_07750 ENOG4105CKP Polysaccharide Biosynthesis Protein AQ980_07760 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AQ980_07765 ENOG41076HS cation diffusion facilitator family transporter AQ980_07770 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AQ980_07780 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AQ980_07785 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AQ980_07795 ENOG4105CUT histidyl-tRNA synthetase AQ980_07805 ENOG4105CUZ uba thif-type nad fad binding protein AQ980_07815 ENOG4108VCI transcription factor, rsfa family AQ980_07820 ENOG4105D1H recombination factor protein RarA AQ980_07830 ENOG4105C3J Cysteine desulfurase AQ980_07835 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AQ980_07845 ENOG4105C7H Helicase, RecD TraA family AQ980_07850 ENOG41060CR AQ980_07865 ENOG4105C02 permease AQ980_07875 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AQ980_07895 ENOG4105HHA aminodeoxychorismate lyase AQ980_07900 ENOG4108VQJ O-methyltransferase AQ980_07905 ENOG4105XYU peptidase (U32 family) AQ980_07910 ENOG4105CFP Peptidase U32 AQ980_07920 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AQ980_07930 ENOG4107XRG penicillin-binding protein AQ980_07960 ENOG4105C28 cystathionine AQ980_07965 ENOG4108EKI Dehydrogenase AQ980_07975 ENOG4108V5C ABC transporter AQ980_07980 ENOG4105S6R Iron-hydroxamate transporter permease subunit AQ980_08020 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AQ980_08030 ENOG4105MIR Phenylalanine 4-monooxygenase AQ980_08080 ENOG4108MUZ hydrolase AQ980_08085 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AQ980_08090 ENOG4105G6Z alkaline phosphatase AQ980_08105 ENOG4108TVJ Nitroreductase AQ980_08125 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ980_08140 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AQ980_08145 ENOG4105CQW ribosome biogenesis GTPase YqeH AQ980_08155 ENOG410812S Rna-binding protein AQ980_08165 ENOG4108WF2 Metal Dependent Phosphohydrolase AQ980_08175 ENOG4105DXX methyltransferase AQ980_08185 ENOG4105KQC Competence protein AQ980_08190 ENOG4108UK2 deaminase AQ980_08195 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AQ980_08205 ENOG4105TQK DNA polymerase iii, delta' subunit AQ980_08230 ENOG4105KVH Transcriptional regulator AQ980_08235 ENOG4105CSA Coproporphyrinogen iii oxidase AQ980_08265 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AQ980_08270 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AQ980_08280 ENOG4105KTH gatB Yqey AQ980_08285 ENOG41068P3 sporulation protein YqfC AQ980_08295 ENOG4105C9A Phoh family AQ980_08300 ENOG4105CTJ Metal Dependent Phosphohydrolase AQ980_08310 ENOG4107YR5 Diacylglycerol kinase AQ980_08315 ENOG4105KG3 cytidine deaminase AQ980_08320 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AQ980_08350 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AQ980_08355 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ980_08370 ENOG4105EGD dinuclear metal center protein, YbgI family AQ980_08395 ENOG41069ZM Protein of unknown function (DUF2624) AQ980_08400 ENOG4108JYZ YitT family AQ980_08405 ENOG4105FDK ABC transporter AQ980_08415 ENOG4105N80 Ferric uptake regulator, Fur family AQ980_08440 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AQ980_08450 ENOG4107RF6 penicillin-binding protein AQ980_08455 ENOG4105EXS phosphate abc transporter AQ980_08460 ENOG4105C8U phosphate abc transporter AQ980_08465 ENOG4105C8U phosphate abc transporter AQ980_08470 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AQ980_08475 ENOG4108UTW Plays a role in the regulation of phosphate uptake AQ980_08490 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AQ980_08500 ENOG4105DKQ ROK family AQ980_08510 ENOG4105C5X domain protein AQ980_08530 ENOG4105C28 cystathionine AQ980_08535 ENOG4105C28 cystathionine AQ980_08550 ENOG4105C3R Methionine synthase AQ980_08555 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AQ980_08675 ENOG4105C0D helicase AQ980_08705 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AQ980_08710 ENOG4105CJ1 ABC, transporter AQ980_08745 ENOG41080TC multidrug resistance protein AQ980_08770 ENOG4105WZW rhodanese family AQ980_08775 ENOG41082GG biotin lipoate A B protein ligase AQ980_08805 ENOG4107YBY Hydrolase AQ980_08815 ENOG4105CBJ Metal-dependent enzyme AQ980_08825 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AQ980_08830 ENOG4105DC7 peptidase M24 AQ980_08855 ENOG4105CD2 stage iii sporulation protein aa AQ980_08860 ENOG4105KR5 Stage iii sporulation protein AQ980_08865 ENOG4108CQH stage III sporulation protein AC AQ980_08870 ENOG4105KQ4 Stage iii sporulation protein ad AQ980_08880 ENOG410644B Stage III sporulation protein af AQ980_08905 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AQ980_08910 ENOG4108ZSR alkaline shock protein AQ980_08920 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AQ980_08935 ENOG4105CTB Polyprenyl synthetase AQ980_08945 ENOG4105DX0 Hemolysin A AQ980_08950 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AQ980_08955 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AQ980_08960 ENOG4105S1Z Stage IV sporulation protein B AQ980_08970 ENOG4107QQR Sporulation AQ980_08985 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AQ980_08995 ENOG4108JUB Transcriptional regulator AQ980_09010 ENOG4107RDP Dehydrogenase AQ980_09030 ENOG4105CPP Dehydrogenase, E1 component AQ980_09035 ENOG4105C7S Dehydrogenase AQ980_09050 ENOG4108QY0 Membrane AQ980_09060 ENOG4105G7B Protein of unknown function (DUF2992) AQ980_09070 ENOG4108HW3 (ABC) transporter AQ980_09075 ENOG4105E5Q amino acid AbC transporter AQ980_09080 ENOG4105CDA abc transporter atp-binding protein AQ980_09085 ENOG4108QEG Membrane AQ980_09090 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AQ980_09105 ENOG4105D9U N-acetyltransferase AQ980_09110 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AQ980_09125 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AQ980_09145 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AQ980_09160 ENOG4105EJQ L-serine dehydratase AQ980_09165 ENOG4105II7 pyrroline-5-carboxylate reductase AQ980_09170 ENOG41069FQ Metallo-beta-lactamase superfamily AQ980_09175 ENOG4108IXY short-chain dehydrogenase reductase AQ980_09190 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) AQ980_09205 ENOG4105DBV ornithine carbamoyltransferase AQ980_09230 ENOG4105CGH 5'-nucleotidase AQ980_09235 ENOG4105DFD Na H antiporter AQ980_09245 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AQ980_09260 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AQ980_09265 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AQ980_09290 ENOG4108R6K riboflavin synthase, subunit alpha AQ980_09295 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AQ980_09315 ENOG4108YM7 Gcn5-related n-acetyltransferase AQ980_09320 ENOG4105ETE Transcriptional regulator (LacI family AQ980_09330 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AQ980_09350 ENOG4105RHY Pfam:UPF0157 AQ980_09360 ENOG4105CPC Aldo Keto reductase AQ980_09380 ENOG4105MZ9 stage II sporulation protein m AQ980_09385 ENOG4105I3K Ferric uptake regulator, Fur family AQ980_09395 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AQ980_09420 ENOG4105D7N magnesium and cobalt transport protein CorA AQ980_09450 ENOG4105DVE abc transporter atp-binding protein AQ980_09455 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AQ980_09460 ENOG4105DZ1 carboxypeptidase AQ980_09465 ENOG41082AN stage II sporulation protein AQ980_09475 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ980_09500 ENOG41090VF Stage v sporulation protein ac AQ980_09505 ENOG4105CZ3 stage V sporulation protein ad AQ980_09515 ENOG4105G6R Stage v sporulation protein ae AQ980_09525 ENOG4105J7I hydrolase AQ980_09530 ENOG4105PTM secreted protein AQ980_09535 ENOG4107ZE5 PPIases accelerate the folding of proteins AQ980_09575 ENOG4105CE4 GlcNAc 6-P deacetylase AQ980_09585 ENOG4105FDP GntR family transcriptional regulator AQ980_09595 ENOG4105CID antiterminator AQ980_09610 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AQ980_09630 ENOG4105BZU Histidine kinase AQ980_09640 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AQ980_09655 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AQ980_09680 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AQ980_09710 ENOG41082BM Transcriptional regulator, arsr family AQ980_09715 ENOG4105C26 Dehydrogenase AQ980_09740 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AQ980_09760 ENOG4105DTD Dehydrogenase AQ980_09765 ENOG4105K7K Transcriptional regulator AQ980_09800 ENOG4105CHU acetyl-coa acetyltransferase AQ980_09840 ENOG4105CG3 alpha amylase, catalytic region AQ980_09850 ENOG4107FKK extracellular solute-binding protein family 1 AQ980_09860 ENOG4105EG2 ABC transporter, permease AQ980_09865 ENOG4105FKQ transcriptional regulator AQ980_09870 ENOG4105CHM Aminotransferase AQ980_09880 ENOG4108HGU Histidine kinase AQ980_09900 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AQ980_09940 ENOG4105UIN AQ980_09950 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AQ980_09965 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AQ980_09970 ENOG4105EPM Diguanylate phosphodiesterase AQ980_09985 ENOG4107IN1 Protein of unknown function (DUF1797) AQ980_09995 ENOG4108XRC Protein of unknown function (DUF458) AQ980_10030 ENOG4107ZYR domain protein AQ980_10035 ENOG4105CN5 Metallo-Beta-Lactamase AQ980_10045 ENOG4108X4Q Hydrolase AQ980_10050 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AQ980_10065 ENOG4105CPP Dehydrogenase, E1 component AQ980_10110 ENOG4105CXN decarboxylase AQ980_10130 ENOG4105ECY inositol monophosphatase AQ980_10140 ENOG4105CI3 gtp-binding protein typa AQ980_10145 ENOG4105QA2 AQ980_10165 ENOG4108IAB Phoh family AQ980_10180 ENOG4105CNI cell division protein FtsW AQ980_10185 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AQ980_10235 ENOG4106UY4 Inherit from COG: Scp-like extracellular AQ980_10250 ENOG4107TB6 phosphoglycerate mutase AQ980_10270 ENOG4106H78 methyltransferase AQ980_10280 ENOG4105H20 Sporulation integral membrane protein YlbJ AQ980_10285 ENOG4105D78 K07001 NTE family protein AQ980_10290 ENOG41063PX domain protein AQ980_10300 ENOG4105KNH Nucleic acid-binding protein AQ980_10325 ENOG41074B2 UPF0747 protein AQ980_10340 ENOG4105CJN penicillin-binding protein AQ980_10345 ENOG4105CJN penicillin-binding protein AQ980_10350 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AQ980_10365 ENOG4105CNI cell division protein FtsW AQ980_10370 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AQ980_10375 ENOG4105D4A Cell wall formation (By similarity) AQ980_10385 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AQ980_10390 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AQ980_10400 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ980_10410 ENOG4105WR5 sporulation protein, YlmC YmxH family AQ980_10415 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AQ980_10420 ENOG4105DFA alanine racemase domain protein AQ980_10430 ENOG41067XK integral membrane protein AQ980_10435 ENOG4105DBK s4 domain protein AQ980_10445 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AQ980_10460 ENOG4105C34 Pseudouridine synthase AQ980_10480 ENOG4105CD3 dihydroorotase AQ980_10490 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AQ980_10495 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AQ980_10510 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AQ980_10535 ENOG4105DC7 peptidase M24 AQ980_10540 ENOG4105F23 Fibronectin-binding protein AQ980_10550 ENOG4105DSJ YicC domain protein AQ980_10570 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AQ980_10575 ENOG4105C25 Primosomal protein n' AQ980_10590 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AQ980_10600 ENOG4108ZF3 Phosphatase AQ980_10605 ENOG4105D9P serine threonine protein kinase AQ980_10610 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AQ980_10615 ENOG4105DJV ribulose-phosphate 3-epimerase AQ980_10620 ENOG4105FJ0 thiamine AQ980_10635 ENOG4108ZAA Alkaline-shock protein AQ980_10640 ENOG4105DP4 dak2 domain fusion protein ylov AQ980_10645 ENOG4105CB5 ATP-dependent DNA helicase recG AQ980_10660 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AQ980_10665 ENOG4105CHR reductase AQ980_10680 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AQ980_10685 ENOG4105EKQ RNA-directed DNA polymerase AQ980_10690 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AQ980_10695 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AQ980_10715 ENOG4105VB6 UPF0109 protein AQ980_10740 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AQ980_10755 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AQ980_10760 ENOG4105C79 DNA protecting protein DprA AQ980_10765 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AQ980_10775 ENOG4108HE4 integrase family AQ980_10805 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AQ980_10815 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AQ980_10820 ENOG4105KNE Phosphatidate cytidylyltransferase AQ980_10825 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AQ980_10830 ENOG4105DZP Membrane-associated zinc metalloprotease AQ980_10840 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AQ980_10850 ENOG4105CHV Transcription elongation factor NusA AQ980_10855 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AQ980_10860 ENOG4105VHM ribosomal protein AQ980_10870 ENOG4105W7A Protein of unknown function (DUF503) AQ980_10885 ENOG4105DTN riboflavin biosynthesis protein ribF AQ980_10905 ENOG4105C1V Peptidase, M16 AQ980_10915 ENOG4105E35 Dipicolinate synthase subunit A AQ980_10920 ENOG4108S0H Dipicolinic acid synthetase, b subunit AQ980_10925 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AQ980_10935 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AQ980_10950 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AQ980_10960 ENOG4105CNU cell division protein FtsK AQ980_10965 ENOG4105FDP GntR family transcriptional regulator AQ980_10970 ENOG4105DIH basic membrane AQ980_10975 ENOG4108JQ9 ABC transporter AQ980_10980 ENOG4105UIB (ABC) transporter AQ980_11000 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AQ980_11005 ENOG4105XZV Protein of unknown function (DUF3243) AQ980_11020 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AQ980_11040 ENOG4105D48 metallophosphoesterase AQ980_11045 ENOG4105MCT stage V sporulation protein S AQ980_11050 ENOG4108IGT Dipeptidase AQ980_11055 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein AQ980_11060 ENOG4105DQU oxidoreductase, subunit beta AQ980_11095 ENOG410890F Dynamin family AQ980_11100 ENOG4105E0M Sulfatase AQ980_11110 ENOG4105F0V Cell wall hydrolase AQ980_11120 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AQ980_11125 ENOG4105CS2 ec 3.2.1.21 AQ980_11130 ENOG4108S3Y transcriptional regulator AQ980_11150 ENOG41067MG lrgb family AQ980_11170 ENOG4105C5E polysaccharide biosynthesis protein AQ980_11190 ENOG4105BZU Histidine kinase AQ980_11215 ENOG4105D03 DNA-3-methyladenine glycosylase II AQ980_11220 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AQ980_11245 ENOG4105E0A ABC, transporter AQ980_11250 ENOG4105NIV Esterase AQ980_11260 ENOG4105VPX protein, conserved in bacteria AQ980_11265 ENOG410681U heavy metal transport detoxification protein AQ980_11270 ENOG4105C59 p-type ATPase AQ980_11280 ENOG4105K70 DNA-binding protein AQ980_11285 ENOG4105TMB Formate nitrite transporter AQ980_11300 ENOG4105C85 amino acid AQ980_11315 ENOG4108SJC Membrane AQ980_11320 ENOG4107QW4 alcohol dehydrogenase AQ980_11325 ENOG4105E98 transcriptional regulator DeoR family AQ980_11330 ENOG4105DE4 1-phosphofructokinase AQ980_11335 ENOG4105DM4 PTS System AQ980_11340 ENOG41069ER domain protein AQ980_11370 ENOG4106F1P AAA ATPase, central domain protein AQ980_11380 ENOG4105EN6 Membrane AQ980_11385 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AQ980_11390 ENOG4105CXI aluminum resistance protein AQ980_11395 ENOG4105KV4 Transcriptional regulator AQ980_11400 ENOG4105C5F glutamine synthetase AQ980_11405 ENOG4105K7K Transcriptional regulator AQ980_11425 ENOG4108SVB resolvase AQ980_11445 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AQ980_11450 ENOG4108HW3 (ABC) transporter AQ980_11485 ENOG4105BZ1 (ABC) transporter AQ980_11490 ENOG4105BZ1 (ABC) transporter AQ980_11530 ENOG41067MG lrgb family AQ980_11535 ENOG4105VAW lrga family AQ980_11540 ENOG4107RSM transcriptional regulator AQ980_11565 ENOG4105DQ6 Transposase AQ980_11570 ENOG4105IYK transposase AQ980_11575 ENOG4105CH2 amidohydrolase AQ980_11585 ENOG4107QIV Cytochrome c biogenesis protein AQ980_11620 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) AQ980_11635 ENOG4105CGP Urocanate hydratase AQ980_11645 ENOG4108903 Formimidoylglutamase AQ980_11650 ENOG4108VJ1 Transcriptional regulator (CarD family AQ980_11660 ENOG4105EKQ RNA-directed DNA polymerase AQ980_11670 ENOG4105CBC glutamate synthase AQ980_11685 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AQ980_11690 ENOG4105FBA Phospholipase Carboxylesterase AQ980_11695 ENOG4105BZU Histidine kinase AQ980_11705 ENOG4107AYK membrAne AQ980_11745 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AQ980_11760 ENOG4105IW1 AmiS UreI transporter AQ980_11765 ENOG4105D9G High-affinity AQ980_11790 ENOG4108IMY Transcriptional regulator AQ980_11795 ENOG4105CEY Amp-dependent synthetase and ligase AQ980_11800 ENOG4107ZYJ bioY protein AQ980_11805 ENOG4107F3J Amp-dependent synthetase and ligase AQ980_11825 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AQ980_11835 ENOG4105E5W Transporter AQ980_11865 ENOG4108I0Z Aconitate hydratase AQ980_11870 ENOG4105BZ1 (ABC) transporter AQ980_11885 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AQ980_11890 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AQ980_11915 ENOG4105D7V transposase AQ980_11925 ENOG4105W8X HesB YadR YfhF-family protein AQ980_11930 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AQ980_11935 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AQ980_11945 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_11950 ENOG4105C0H protease AQ980_11955 ENOG4105K4P CoA-binding domain protein AQ980_11965 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AQ980_11975 ENOG4105D9R oxidoreductase AQ980_11995 ENOG4105CIG ABC transporter AQ980_12005 ENOG4105EMN RNA polymerase sigma factor AQ980_12015 ENOG4108KGH TRANSCRIPTIONal AQ980_12070 ENOG4105CUB amino acid AQ980_12085 ENOG4105E1K spore germination protein AQ980_12095 ENOG4108JB9 formate dehydrogenase AQ980_12105 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AQ980_12110 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AQ980_12120 ENOG4105TMB Formate nitrite transporter AQ980_12125 ENOG4105D06 uba thif-type nad fad binding protein AQ980_12130 ENOG4105CVM Molybdenum cofactor synthesis domain protein AQ980_12135 ENOG4108ZAF Molybdopterin AQ980_12145 ENOG4105D1F ATP-binding protein AQ980_12160 ENOG410696E Membrane AQ980_12165 ENOG4105FR1 rard protein AQ980_12175 ENOG4105EWU Squalene--hopene cyclase AQ980_12185 ENOG4105CHR reductase AQ980_12190 ENOG4105C26 Dehydrogenase AQ980_12200 ENOG4108IA2 Sodium pantothenate symporter AQ980_12215 ENOG4106IQC argininosuccinate lyase AQ980_12225 ENOG410904N short-chain dehydrogenase reductase AQ980_12245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AQ980_12270 ENOG4105VEQ Cold shock protein AQ980_12290 ENOG4108R1P AQ980_12300 ENOG41073R8 VanW family AQ980_12305 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AQ980_12315 ENOG4105KT7 mgtC SapB transporter AQ980_12325 ENOG4105BZU Histidine kinase AQ980_12350 ENOG4105C5H ABC transporter AQ980_12430 ENOG4105FAW cDP-glucose 4,6-dehydratase AQ980_12435 ENOG4108IAJ Nad-dependent epimerase dehydratase AQ980_12445 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AQ980_12470 ENOG4105EKQ RNA-directed DNA polymerase AQ980_12500 ENOG4105E1K spore germination protein AQ980_12510 ENOG4108M1A Chitin-binding protein AQ980_12515 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C AQ980_12525 ENOG4105CEP NADH dehydrogenase AQ980_12530 ENOG4107TPS domain protein AQ980_12540 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AQ980_12565 ENOG4105CQB FAD linked oxidase domain protein AQ980_12570 ENOG4105C09 Bile acid AQ980_12595 ENOG4105CIS alcohol dehydrogenase AQ980_12600 ENOG41082BM Transcriptional regulator, arsr family AQ980_12615 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AQ980_12640 ENOG4108A04 Beta-lactamase AQ980_12670 ENOG4105DPN Oligoendopeptidase f AQ980_12675 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AQ980_12680 ENOG4105E5K Alpha-amylase AQ980_12685 ENOG4105C98 muts2 protein AQ980_12700 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AQ980_12710 ENOG4107V2S Transcriptional regulator AQ980_12720 ENOG4107CUJ Protein of unknown function (DUF2690) AQ980_12725 ENOG41068WN AQ980_12745 ENOG4105NX3 Membrane AQ980_12750 ENOG4105DQ5 transport system permease protein AQ980_12755 ENOG4105EHG Permease protein AQ980_12760 ENOG4108MES Periplasmic binding protein AQ980_12765 ENOG4105WCN acetyltransferase AQ980_12775 ENOG4107R3E Citrate transporter AQ980_12785 ENOG4108TN2 lmbE family AQ980_12870 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) AQ980_12935 ENOG4108ZJ4 polysaccharide deacetylase AQ980_12950 ENOG4105KVH Transcriptional regulator AQ980_12955 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AQ980_12965 ENOG4105KNA -acetyltransferase AQ980_12980 ENOG4105JAB phenazine biosynthesis protein, phzf family AQ980_13020 ENOG4105D9R oxidoreductase AQ980_13025 ENOG4108TZY GntR Family Transcriptional Regulator AQ980_13050 ENOG4105C44 Serine transporter AQ980_13065 ENOG4105KVH Transcriptional regulator AQ980_13070 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AQ980_13075 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AQ980_13080 ENOG4108UX3 '-nucleotidase AQ980_13085 ENOG4105C8Q Methyl-accepting chemotaxis AQ980_13115 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AQ980_13120 ENOG4105CV1 Transketolase (EC 2.2.1.1) AQ980_13130 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AQ980_13135 ENOG4105C6Z Gluconate AQ980_13140 ENOG4105CMG Carbohydrate kinase AQ980_13145 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AQ980_13150 ENOG4105XDF Protein of unknown function (DUF1272) AQ980_13155 ENOG4105DDN Pentapeptide repeat-containing protein AQ980_13190 ENOG4105FAW cDP-glucose 4,6-dehydratase AQ980_13195 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AQ980_13210 ENOG4105C37 (CBS) domain AQ980_13240 ENOG4105EV4 Multidrug resistance protein mdtH AQ980_13250 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AQ980_13280 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AQ980_13285 ENOG4105C31 Tryptophanyl-tRNA synthetase AQ980_13355 ENOG4108PSK reductase AQ980_13385 ENOG4108RCM Nitroreductase AQ980_13390 ENOG4105KVH Transcriptional regulator AQ980_13400 ENOG4108Z66 YbaK ebsC protein AQ980_13470 ENOG4105DYS nad(p)h dehydrogenase (quinone) AQ980_13480 ENOG4105CRW Short chain fatty acid transporter AQ980_13495 ENOG4105CZM Major Facilitator AQ980_13500 ENOG4107MII Sugar-specific transcriptional regulator TrmB AQ980_13515 ENOG4108ISG Major Facilitator AQ980_13525 ENOG4105PNM synthesis protein AQ980_13530 ENOG4108VXD carboxy-peptidase AQ980_13660 ENOG4108IMY Transcriptional regulator AQ980_13675 ENOG4107VMI polysaccharide deacetylase AQ980_13680 ENOG4108RZE Tetr family transcriptional regulator AQ980_13685 ENOG4105CAQ asparagine synthetase AQ980_13720 ENOG4105EJQ L-serine dehydratase AQ980_13725 ENOG4105C44 Serine transporter AQ980_13750 ENOG4105F6S Spore photoproduct lyase AQ980_13760 ENOG4105CVK Glutamate decarboxylase AQ980_13775 ENOG4108NHD germination protein AQ980_13785 ENOG4105CNI cell division protein FtsW AQ980_13790 ENOG4105CJW magnesium transporter AQ980_13800 ENOG4107RVG penicillin-binding protein AQ980_13815 ENOG4107RF6 penicillin-binding protein AQ980_13820 ENOG4107RF6 penicillin-binding protein AQ980_13850 ENOG4105CJ1 ABC, transporter AQ980_13860 ENOG4107Z3H Transcriptional regulator, TetR family AQ980_13875 ENOG4105C1G acyl-Coa dehydrogenase AQ980_13880 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AQ980_13885 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AQ980_13890 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AQ980_13895 ENOG4105E39 Enoyl-CoA hydratase AQ980_13900 ENOG4107QX3 carboxylase AQ980_13905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AQ980_13930 ENOG41085W3 Transposase AQ980_13945 ENOG4105DBI uridine monophosphokinase AQ980_13960 ENOG4105DZ1 carboxypeptidase AQ980_13980 ENOG4105T9C HD domain AQ980_13990 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AQ980_14010 ENOG41075H3 AraC family transcriptional regulator AQ980_14055 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AQ980_14065 ENOG4105MDS 4-oxalocrotonate tautomerase AQ980_14070 ENOG4107V2S Transcriptional regulator AQ980_14080 ENOG4105CJ1 ABC, transporter AQ980_14115 ENOG4105EFA 4-hydroxyphenylacetate AQ980_14140 ENOG4105EKQ RNA-directed DNA polymerase AQ980_14160 ENOG410900G Protein of unknown function (DUF421) AQ980_14165 ENOG4108V4B ThiJ pfpI AQ980_14175 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AQ980_14185 ENOG4105DK7 lysyl-tRNA synthetase AQ980_14210 ENOG4105EKQ RNA-directed DNA polymerase AQ980_14255 ENOG4105D6E homoserine dehydrogenase AQ980_14265 ENOG4105CPF Cell wall formation (By similarity) AQ980_14270 ENOG4105ETU transcriptional activator (TenA AQ980_14305 ENOG41085W3 Transposase AQ980_14365 ENOG410667J hydrolase AQ980_14370 ENOG4105BZU Histidine kinase AQ980_14375 ENOG4107RF6 penicillin-binding protein AQ980_14400 ENOG4108JJB ABC transporter AQ980_14410 ENOG4108HGU Histidine kinase AQ980_14415 ENOG4105VTR Integrase AQ980_14475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_14480 ENOG4105GR3 Histidine kinase AQ980_14485 ENOG4105CB2 alcohol dehydrogenase AQ980_14490 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AQ980_14495 ENOG4105CJN penicillin-binding protein AQ980_14540 ENOG4105F27 Major Facilitator AQ980_14545 ENOG4107Y80 Major Facilitator superfamily AQ980_14565 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AQ980_14585 ENOG4107Y9U Membrane AQ980_14605 ENOG4105EGD dinuclear metal center protein, YbgI family AQ980_14630 ENOG4105FCD Major Facilitator AQ980_14640 ENOG4105E09 nadh pyrophosphatase AQ980_14645 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AQ980_14670 ENOG4108XI2 Domain of unknown function (DUF1963) AQ980_14695 ENOG4108NRW Phospholipase, patatin family AQ980_14700 ENOG4105KWG Pfam:DUF1696 AQ980_14710 ENOG4108YYS metal-dependent hydrolase (By similarity) AQ980_14725 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AQ980_14735 ENOG4105PKS Excinuclease abc c subunit domain protein AQ980_14755 ENOG4107VFR oxidoreductase AQ980_14780 ENOG4105U0R haloacid dehalogenase-like hydrolase AQ980_14785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_14790 ENOG4105BZU Histidine kinase AQ980_14810 ENOG4107WD8 ABC transporter, permease AQ980_14825 ENOG4105DY8 decarboxylase AQ980_14870 ENOG4108IUM Glycogen debranching enzyme AQ980_14880 ENOG4105CGH 5'-nucleotidase AQ980_14895 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AQ980_14900 ENOG4105FDR Membrane AQ980_14905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ980_14960 ENOG4105MSI germination protein ypeb AQ980_14990 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) AQ980_14995 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) AQ980_15000 ENOG4107Z3H Transcriptional regulator, TetR family AQ980_15030 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AQ980_15065 ENOG41062ES Transcriptional regulator AQ980_15080 ENOG4107QKR Dehydrogenase AQ980_15090 ENOG4107RUY (E1 component), alpha subunit AQ980_15100 ENOG4105JHE Major Facilitator Superfamily AQ980_15120 ENOG4105EKQ RNA-directed DNA polymerase AQ980_15135 ENOG4105E1F short-chain dehydrogenase reductase AQ980_15140 ENOG4105RHY Pfam:UPF0157 AQ980_15180 ENOG4107SQ8 Glycine betaine AQ980_15185 ENOG4108IJ7 Glycine betaine AQ980_15210 ENOG4105E66 phosphoriboisomerase A AQ980_15215 ENOG41082BV acetyltransferase AQ980_15220 ENOG4108M1A Chitin-binding protein AQ980_15225 ENOG41087PP glycosyltransferase MGT family AQ980_15250 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AQ980_15255 ENOG4105MSB protein, conserved in bacteria AQ980_15280 ENOG4108Z7F N-acetyltransferase AQ980_15300 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AQ980_15305 ENOG4105EEM helicase AQ980_15315 ENOG41066HZ AIG2-like family AQ980_15320 ENOG4105C9U ATP-dependent DNA helicase RecQ AQ980_15340 ENOG4105DQ6 Transposase AQ980_15360 ENOG4105DQ6 Transposase AQ980_15395 ENOG4108M1A Chitin-binding protein AQ980_15410 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AQ980_15420 ENOG4105BZG amino acid carrier protein AQ980_15425 ENOG4105C26 Dehydrogenase AQ980_15430 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AQ980_15435 ENOG4105CTU Proline racemase AQ980_15440 ENOG4105CTU Proline racemase AQ980_15445 ENOG41080HI glycine oxidase AQ980_15455 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein AQ980_15485 ENOG4107T5V SNARE associated Golgi AQ980_15495 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AQ980_15515 ENOG4105DTQ mandelate racemase muconate lactonizing AQ980_15530 ENOG4107SET aldo keto reductase AQ980_15565 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) AQ980_15570 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AQ980_15575 ENOG4105BZU Histidine kinase AQ980_15580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_15610 ENOG4105DPN Oligoendopeptidase f AQ980_15615 ENOG4105EPR degv family AQ980_15675 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AQ980_15680 ENOG4106K7D Major facilitator family transporter AQ980_15700 ENOG4107BMA Transglycosylase associated protein AQ980_15715 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AQ980_15750 ENOG4105CHM Aminotransferase AQ980_15765 ENOG4108ZMI UPF0477 protein AQ980_15780 ENOG4105DVE abc transporter atp-binding protein AQ980_15835 ENOG4105C02 permease AQ980_15850 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AQ980_15855 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AQ980_15860 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AQ980_15865 ENOG4105D7T ABC transporter AQ980_15890 ENOG4108AQF aminoglycoside N(3)-acetyltransferase AQ980_15930 ENOG4107VC0 DNA alkylation repair enzyme AQ980_15935 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AQ980_15940 ENOG4107VMI polysaccharide deacetylase AQ980_15945 ENOG4108ZCF integral membrane protein AQ980_15950 ENOG4105E0M Sulfatase AQ980_15955 ENOG4105C5H ABC transporter AQ980_15970 ENOG4105EYF MMPL domain protein AQ980_15975 ENOG41082JN Transcriptional regulator AQ980_16000 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AQ980_16005 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AQ980_16045 ENOG41069ER domain protein AQ980_16055 ENOG4105DNP FAD linked oxidase domain protein AQ980_16075 ENOG4105D4B ABC, transporter AQ980_16080 ENOG4105F5R ABC transporter AQ980_16085 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AQ980_16095 ENOG4105DKT Transcriptional regulator AQ980_16100 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AQ980_16110 ENOG41061GT Aldolase AQ980_16125 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AQ980_16155 ENOG4105DQ6 Transposase AQ980_16170 ENOG4105II7 pyrroline-5-carboxylate reductase AQ980_16180 ENOG4107258 Transcriptional regulator AQ980_16195 ENOG4105ECK Fatty Acid Desaturase AQ980_16205 ENOG4107RBI VanW family AQ980_16210 ENOG4105G6Z alkaline phosphatase AQ980_16220 ENOG4105VMP Transcriptional regulator AQ980_16240 ENOG41068WN AQ980_16275 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AQ980_16300 ENOG4105CKK Glycosyl transferase, family 2 AQ980_16320 ENOG4105CKK Glycosyl transferase, family 2 AQ980_16345 ENOG4105C8Y Acetylornithine aminotransferase AQ980_16390 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AQ980_16450 ENOG4108IBT Inherit from COG: transposase AQ980_16470 ENOG4108TVJ Nitroreductase AQ980_16475 ENOG4105FS7 Transcriptional regulator AQ980_16490 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) AQ980_16495 ENOG4105WEC Molybdate metabolism regulator AQ980_16515 ENOG4108DMH HTH_ARAC AQ980_16520 ENOG4108FWV Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AQ980_16525 ENOG4108XET gCN5-related N-acetyltransferase AQ980_16540 ENOG4108PCN EamA-like transporter family AQ980_16550 ENOG4107XJU UPF0178 protein AQ980_16585 ENOG410635A Membrane AQ980_16595 ENOG4108IQI permease AQ980_16640 ENOG4107RF6 penicillin-binding protein AQ980_16650 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AQ980_16680 ENOG4105P4J Allophanate hydrolase, subunit 1 AQ980_16685 ENOG4107258 Transcriptional regulator AQ980_16695 ENOG4106N3A copper homeostasis protein cutc AQ980_16700 ENOG4108ZHR arsR family transcriptional regulator AQ980_16710 ENOG4105FDT acyl-CoA dehydrogenase AQ980_16725 ENOG4105DWD nucleoside recognition domain protein AQ980_16735 ENOG4105M18 -acetyltransferase AQ980_16755 ENOG4105DQ6 Transposase AQ980_16760 ENOG4105IYK transposase AQ980_16795 ENOG4107EXU Short-chain dehydrogenase reductase Sdr AQ980_16820 ENOG4105E2A Dehydrogenase AQ980_16825 ENOG4105BZU Histidine kinase AQ980_16850 ENOG41075H3 AraC family transcriptional regulator AQ980_16870 ENOG4105CGH 5'-nucleotidase AQ980_16880 ENOG4105CHJ isochorismatase hydrolase AQ980_16975 ENOG4108606 TspO/MBR family AQ980_16980 ENOG4105CVP deoxyribo-dipyrimidine photolyase AQ980_17005 ENOG4105F2M alpha beta hydrolase fold-3 domain protein AQ980_17020 ENOG4108TWJ NADH dehydrogenase subunit 5 AQ980_17025 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AQ980_17030 ENOG4107VMI polysaccharide deacetylase AQ980_17035 ENOG4105KY5 gCN5-related N-acetyltransferase AQ980_17040 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AQ980_17045 ENOG4105ECQ AraC Family Transcriptional Regulator AQ980_17050 ENOG4105Z7P Acetyltransferase (GNAT) family AQ980_17060 ENOG4105D6J arsenicaL-resistance protein AQ980_17065 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AQ980_17070 ENOG41085FC arsR family transcriptional regulator AQ980_17080 ENOG4105F27 Major Facilitator AQ980_17085 ENOG4105M4P Tetr family transcriptional regulator AQ980_17090 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AQ980_17095 ENOG4108YXU transcriptional regulator AsnC family AQ980_17175 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AQ980_17180 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ980_17200 ENOG4105K6H D-cysteine desulfhydrase AQ980_17210 ENOG4105E0Y RtcB Protein AQ980_17220 ENOG4105JQZ Methyltransferase AQ980_17240 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) AQ980_17245 ENOG4105BZU Histidine kinase AQ980_17255 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AQ980_17285 ENOG4108JQ1 Dehydrogenase AQ980_17290 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AQ980_17315 ENOG4108KDT Molybdate metabolism regulator AQ980_17325 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AQ980_17400 ENOG4105CJW magnesium transporter AQ980_17410 ENOG4105EKQ RNA-directed DNA polymerase AQ980_17455 ENOG4105W8Z 4'-phosphopantetheinyl transferase AQ980_17490 ENOG4105EQK -acetyltransferase AQ980_17495 ENOG4105EJ9 Membrane AQ980_17505 ENOG4105DQ6 Transposase AQ980_17510 ENOG4105IYK transposase AQ980_17515 ENOG4105KRN Transcriptional regulator, abrb family AQ980_17540 ENOG4105CIN aminoacyl-histidine dipeptidase AQ980_17565 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AQ980_17570 ENOG4105K56 Transcriptional regulator AQ980_17575 ENOG4107RA9 decarboxylase AQ980_17580 ENOG4108I0C methyltransferase AQ980_17590 ENOG41088CC tellurite resistance protein tehB AQ980_17605 ENOG4108RZE Tetr family transcriptional regulator AQ980_17615 ENOG4105C1J atp-dependent rna helicase AQ980_17625 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AQ980_17645 ENOG4108INS Transcriptional regulator AQ980_17650 ENOG4105C7B Threonine dehydratase AQ980_17665 ENOG4105RD7 BadF BadG BcrA BcrD AQ980_17690 ENOG4105F32 YngK protein AQ980_17715 ENOG4108KPJ rna polymerase sigma factor AQ980_17720 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) AQ980_17755 ENOG4108JCI Transcriptional regulator AQ980_17785 ENOG4105BZ1 (ABC) transporter AQ980_17790 ENOG4105BZ1 (ABC) transporter AQ980_17805 ENOG4108RPX mosc domain containing protein AQ980_17810 ENOG4105DND Transcriptional regulator AQ980_17830 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AQ980_17835 ENOG4107V2S Transcriptional regulator AQ980_17865 ENOG41068WN AQ980_17875 ENOG4105C1Q protoporphyrinogen oxidase AQ980_17900 ENOG4105WCN acetyltransferase AQ980_17925 ENOG4105EYF MMPL domain protein AQ980_17935 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AQ980_17960 ENOG4108Y4K DNA-binding transcriptional activator AQ980_17970 ENOG41081I9 integral membrane protein AQ980_18010 ENOG4105C19 ABC transporter AQ980_18015 ENOG4105C22 threonyL-tRNA synthetase AQ980_18020 ENOG4105FE9 pseudouridine synthase AQ980_18040 ENOG4105BZG amino acid carrier protein AQ980_18060 ENOG4105K70 DNA-binding protein AQ980_18075 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ980_18080 ENOG4105WQT MbtH domain protein AQ980_18085 ENOG4105CEY Amp-dependent synthetase and ligase AQ980_18090 ENOG4105WQI isochorismatase AQ980_18095 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AQ980_18100 ENOG4105E4F Isochorismate synthase AQ980_18105 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AQ980_18110 ENOG4105FCD Major Facilitator AQ980_18135 ENOG4105EYH Exonuclease AQ980_18140 ENOG4107RFY SbcCD D subunit AQ980_18155 ENOG4105E39 Enoyl-CoA hydratase AQ980_18160 ENOG4105N14 lysine exporter protein LysE YggA AQ980_18170 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AQ980_18175 ENOG4105C1G acyl-Coa dehydrogenase AQ980_18180 ENOG4105CR4 methylisocitrate lyase AQ980_18185 ENOG4105DXD 2-methylcitrate dehydratase AQ980_18195 ENOG4105W8X HesB YadR YfhF-family protein AQ980_18200 ENOG4105CZM Major Facilitator AQ980_18210 ENOG4105BZ4 penicillin-binding protein AQ980_18275 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AQ980_18310 ENOG4105SZ6 Thioredoxin AQ980_18320 ENOG410841Q phosphoesterase PA-phosphatase related protein AQ980_18365 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AQ980_18370 ENOG4108JUB Transcriptional regulator AQ980_18375 ENOG4108TSC N-acetyltransferase AQ980_18380 ENOG4107S4Y M20 DapE family protein YgeY AQ980_18395 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AQ980_18420 ENOG4105C37 (CBS) domain AQ980_18455 ENOG4105E90 ABC transporter AQ980_18460 ENOG4108IJ8 ABC transporter AQ980_18490 ENOG4108YV3 Protein of unknown function (DUF2711) AQ980_18500 ENOG4105C6Z Gluconate AQ980_18505 ENOG4105CMG Carbohydrate kinase AQ980_18525 ENOG4107ZY0 Phenazine biosynthesis-like protein AQ980_18530 ENOG4106KNT transcriptional regulator AQ980_18535 ENOG4105WH1 Two component transcriptional regulator luxr family AQ980_18540 ENOG4105BZU Histidine kinase AQ980_18545 ENOG4105D8X mechanosensitive ion channel AQ980_18575 ENOG4105F0I Aminotransferase AQ980_18580 ENOG4108MES Periplasmic binding protein AQ980_18600 ENOG4105CAQ asparagine synthetase AQ980_18605 ENOG4107Y70 Heat shock protein AQ980_18610 ENOG4108KF3 Electron transport protein SCO1 SenC AQ980_18620 ENOG4108RCR degv family AQ980_18630 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AQ980_18640 ENOG4108UT2 hemolysin iii AQ980_18645 ENOG4105E9Q Acyl-transferase AQ980_18650 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AQ980_18655 ENOG4107RVG penicillin-binding protein AQ980_18665 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AQ980_18670 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) AQ980_18685 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 AQ980_18710 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AQ980_18715 ENOG4105VMP Transcriptional regulator AQ980_18725 ENOG4105KD7 acetyltransferase AQ980_18745 ENOG4105CY2 Citrate transporter AQ980_18770 ENOG4105C8J )-transporter AQ980_18775 ENOG4105C5S asparaginyl-tRNA synthetase AQ980_18785 ENOG4105IYK transposase AQ980_18790 ENOG4105DQ6 Transposase AQ980_18810 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AQ980_18835 ENOG4105C75 arginyL-tRNA synthetase AQ980_18840 ENOG4107YX5 Pfam:DUF548 AQ980_18865 ENOG4108UUM single-stranded DNA-binding protein AQ980_18975 ENOG4105C5H ABC transporter AQ980_19000 ENOG4108FPN Integrase AQ980_19005 ENOG4108KU9 integrase family AQ980_19020 ENOG4107TSN permease AQ980_19045 ENOG4105MCT stage V sporulation protein S AQ980_19080 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AQ980_19085 ENOG4108IFG nitrite reductase, (NAD(P)H) AQ980_19090 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AQ980_19095 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AQ980_19100 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AQ980_19105 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AQ980_19120 ENOG41067WU Molybdopterin converting factor (Subunit 1) AQ980_19125 ENOG4108ZAF Molybdopterin AQ980_19130 ENOG4105CVM Molybdenum cofactor synthesis domain protein AQ980_19135 ENOG4105D06 uba thif-type nad fad binding protein AQ980_19140 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AQ980_19145 ENOG4107V6Q Cyclic nucleotide-binding domain AQ980_19155 ENOG4105R3A Nitrate reductase AQ980_19160 ENOG4108IUE nitrate reductase beta subunit AQ980_19175 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AQ980_19190 ENOG4108V06 Glutathione peroxidase AQ980_19205 ENOG4105CNW domain protein AQ980_19220 ENOG4105EMN RNA polymerase sigma factor AQ980_19230 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AQ980_19240 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AQ980_19245 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AQ980_19265 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AQ980_19290 ENOG4105KBJ sporulation protein ytfj AQ980_19385 ENOG4108MGT Required for secretion of EsxA and EsxB AQ980_19390 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) AQ980_19420 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AQ980_19450 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ980_19455 ENOG4108JYZ YitT family AQ980_19460 ENOG41087PP glycosyltransferase MGT family AQ980_19470 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AQ980_19525 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis AQ980_19535 ENOG41085W3 Transposase AQ980_19570 ENOG4105EKQ RNA-directed DNA polymerase AQ980_19620 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AQ980_19630 ENOG4105CAR Terminase, large subunit AQ980_19755 ENOG4106050 phage regulatory protein, rha family AQ980_19795 ENOG4108ZRV stage ii sporulation protein p AQ980_19825 ENOG4108VXD carboxy-peptidase AQ980_19835 ENOG4108ZRV stage ii sporulation protein p AQ980_19855 ENOG4108Z7R Chaperone CsaA AQ980_19865 ENOG4105IYK transposase AQ980_19870 ENOG4105DQ6 Transposase AQ980_19885 ENOG4105C37 (CBS) domain AQ980_19890 ENOG4105SXS Protein of unknown function (DUF456) AQ980_19910 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AQ980_19915 ENOG4108S4H thioesterase Superfamily protein AQ980_19925 ENOG4108PJD permease AQ980_19940 ENOG4107T5V SNARE associated Golgi AQ980_19985 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AQ980_19995 ENOG4105K4T epimerase AQ980_20005 ENOG4105EKQ RNA-directed DNA polymerase AQ980_20025 ENOG4105DSE periplasmic solute binding protein AQ980_20035 ENOG4105CKI cobalamin synthesis protein AQ980_20045 ENOG4107QM2 Aldo Keto reductase AQ980_20050 ENOG4105VMI -acetyltransferase AQ980_20065 ENOG4105DEN Luciferase family AQ980_20075 ENOG4105DQ6 Transposase AQ980_20090 ENOG4108WPJ Ferritin-like domain AQ980_20095 ENOG4108K88 Membrane AQ980_20115 ENOG4105C8Q Methyl-accepting chemotaxis AQ980_20140 ENOG4105KAF membrAne AQ980_20150 ENOG4107XZQ multidrug resistance protein AQ980_20155 ENOG4105CPC Aldo Keto reductase AQ980_20160 ENOG4105YVS arsR family transcriptional regulator AQ980_20170 ENOG4105KRN Transcriptional regulator, abrb family AQ980_20220 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ980_20225 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AQ980_20235 ENOG4105YWU small acid-soluble spore protein AQ980_20240 ENOG4108WBH protein TIM barrel AQ980_20255 ENOG4105CEY Amp-dependent synthetase and ligase AQ980_20285 ENOG4105D7V transposase AQ980_20295 ENOG4105VRR gCN5-related N-acetyltransferase AQ980_20300 ENOG4105KT7 mgtC SapB transporter AQ980_20310 ENOG4107VMI polysaccharide deacetylase AQ980_20315 ENOG4105BZU Histidine kinase AQ980_20320 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ980_20330 ENOG4108KGH TRANSCRIPTIONal AQ980_20345 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AQ980_20355 ENOG4105D6E homoserine dehydrogenase AQ980_20360 ENOG41085W3 Transposase AQ980_20380 ENOG4108ZJ4 polysaccharide deacetylase AQ980_20385 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AQ980_20395 ENOG4105BZU Histidine kinase AQ980_20400 ENOG4105EFI regulatoR AQ980_20405 ENOG4105BZ1 (ABC) transporter AQ980_20460 ENOG4108UT6 Transferase hexapeptide repeat containing protein AQ980_20470 ENOG4105K64 Glycosyl transferase, family 2 AQ980_20480 ENOG4108JJ8 (ABC) transporter AQ980_20485 ENOG4108JJ9 ABC, transporter AQ980_20490 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AQ980_20495 ENOG4105C4M (Ubiquinol oxidase) subunit I AQ980_20525 ENOG4105EGI Transcriptional regulator AQ980_20535 ENOG4105C32 Amino acid ABC transporter (Permease) AQ980_20540 ENOG4108IV0 ABC, transporter AQ980_20545 ENOG4105C0Z ABC transporter AQ980_20555 ENOG4105CKI cobalamin synthesis protein AQ980_20565 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AQ980_20570 ENOG4106F5Q Membrane AQ980_20585 ENOG4108TVJ Nitroreductase AQ980_20590 ENOG4107ZXU DSBA oxidoreductase AQ980_20595 ENOG4108Z40 Transcriptional regulator AQ980_20600 ENOG4105GZI Transcriptional regulator AQ980_20605 ENOG4107RT3 EamA-like transporter family AQ980_20610 ENOG4105KTB nuclear export factor GLE1 AQ980_20615 ENOG4108T5E Copper resistance protein AQ980_20655 ENOG4107R16 Multicopper oxidase AQ980_20665 ENOG4107RAQ aminopeptidase AQ980_20690 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AQ980_20695 ENOG4105D9N nucleoside AQ980_20705 ENOG4107RHR regulatoR AQ980_20720 ENOG4105K8R UPF0145 protein AQ980_20745 ENOG4105C0X amino acid AQ980_20755 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AQ980_20770 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AQ980_20775 ENOG41068WN AQ980_20795 ENOG4105K5X acetyltransferase AQ980_20800 ENOG4105CYC Transferase AQ980_20805 ENOG4105DY9 regulatoR AQ980_20815 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AQ980_20820 ENOG4105C6X Major Facilitator AQ980_20845 ENOG4105C7B Threonine dehydratase AQ980_20850 ENOG4105C01 Dihydroxy-acid dehydratase AQ980_20855 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AQ980_20865 ENOG4105C7K acetolactate synthase AQ980_20870 ENOG4105CM2 brancheD-chain amino acid aminotransferase AQ980_20875 ENOG4105CHR reductase AQ980_20900 ENOG4105H67 Protein of unknown function (DUF421) AQ980_20905 ENOG4105X5K response regulator receiver protein AQ980_20910 ENOG4105C8J )-transporter AQ980_20930 ENOG4105C6T cysteine synthase AQ980_20935 ENOG4105EU0 Major facilitator Superfamily AQ980_20940 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AQ980_20950 ENOG4105DXI Major Facilitator superfamily AQ980_20960 ENOG4105U3E Transcriptional regulator AQ980_20965 ENOG4105CSR polyphosphate kinase 2 AQ980_20980 ENOG4105E09 nadh pyrophosphatase AQ980_20985 ENOG4105FVX AQ980_21015 ENOG41067QW Transcriptional regulator AQ980_21025 ENOG4105DQ6 Transposase AQ980_21060 ENOG4105C6K Malic enzyme AQ980_21065 ENOG4108IJ0 Aspartate ammonia-lyase AQ980_21080 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AQ980_21105 ENOG4105CJ1 ABC, transporter AQ980_21140 ENOG4106BRA Membrane AQ980_21160 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AQ980_21180 ENOG4105EC3 peptidase S51, dipeptidase E AQ980_21185 ENOG4107QJQ Mate efflux family protein AQ980_21210 ENOG4105C9Q fumarate hydratase class II AQ980_21220 ENOG4105VUF Transcriptional regulator AQ980_21225 ENOG4105DFD Na H antiporter AQ980_21240 ENOG4108PJD permease AQ980_21245 ENOG4105CKI cobalamin synthesis protein AQ980_21255 ENOG4108UZ3 Transporter AQ980_21260 ENOG4105DRR Transcriptional regulator, GntR family AQ980_21270 ENOG4105PGM cation diffusion facilitator family transporter AQ980_21290 ENOG4105CAQ asparagine synthetase AQ980_21310 ENOG41085W3 Transposase AQ980_21315 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) AQ980_21325 ENOG4105CVJ phosphoglycerate mutase AQ980_21355 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component AQ980_21360 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AQ980_21365 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AQ980_21370 ENOG4105DUM transcriptional regulator, lysR family AQ980_21430 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AQ980_21435 ENOG4105KTQ flagellar basal-body rod protein AQ980_21440 ENOG4105FZW flagellar biosynthesis regulator FlhF AQ980_21445 ENOG4105D7B Flagellar biosynthesis protein flha AQ980_21450 ENOG4105D00 flagellar biosynthetic protein flhB AQ980_21460 ENOG4105VS8 Flagellar biosynthetic protein fliq AQ980_21465 ENOG4105CN7 Flagellar biosynthetic protein FliP AQ980_21475 ENOG4105DD5 Flagellar motor switch protein AQ980_21480 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AQ980_21490 ENOG4105E4C Lytic transglycosylase catalytic AQ980_21495 ENOG4105I03 Flagellin AQ980_21500 ENOG4105I03 Flagellin AQ980_21505 ENOG4105I03 Flagellin AQ980_21510 ENOG4105I03 Flagellin AQ980_21520 ENOG4107R88 Chemotaxis protein (CheV) AQ980_21535 ENOG4105BZE flagellar hook protein, FlgE AQ980_21565 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AQ980_21570 ENOG4107U2N Flagellar M-ring protein AQ980_21575 ENOG41075Z6 flagellar hook-basal body complex protein fliE AQ980_21580 ENOG4108ZC9 flagellar basal-body rod protein flgc AQ980_21585 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AQ980_21605 ENOG4105DTJ flagellar hook-associated protein AQ980_21610 ENOG4105E1Q flagellar hook-associated protein AQ980_21630 ENOG4105BZU Histidine kinase AQ980_21645 ENOG4105DD5 Flagellar motor switch protein AQ980_21650 ENOG4105CBS Chea signal transduction histidine kinase AQ980_21655 ENOG4107YTP response regulator receiver protein AQ980_21660 ENOG4105ER2 Ompa motb domain protein AQ980_21665 ENOG4107R0U MotA TolQ exbB proton channel AQ980_21675 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AQ980_21715 ENOG41080C8 DUF218 domain AQ980_21720 ENOG4105H67 Protein of unknown function (DUF421) AQ980_21730 ENOG4108Z5V transcriptional regulator, merr family AQ980_21735 ENOG4105CN5 Metallo-Beta-Lactamase AQ980_21740 ENOG4107RWR Sodium hydrogen exchanger AQ980_21750 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AQ980_21815 ENOG41081VK Ribonuclease AQ980_21835 ENOG4108SZE gCN5-related N-acetyltransferase AQ980_21850 ENOG4105CPK Glycosyl transferase (Group 1 AQ980_21880 ENOG4105HTX biosynthesis protein AQ980_21925 ENOG4105KHC sulfurtransferase AQ980_21935 ENOG4108W0I acetyltransferase AQ980_21945 ENOG410890F Dynamin family AQ980_21950 ENOG4105DHF Membrane AQ980_21955 ENOG4105C2W permease AQ980_21960 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AQ980_21965 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AQ980_21975 ENOG4105CTD carboxy-peptidase AQ980_21980 ENOG4105DVT helicase AQ980_21990 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AQ980_22000 ENOG4106F55 Protein of unknown function (DUF1273) AQ980_22040 ENOG4105BZ4 penicillin-binding protein AQ980_22050 ENOG4105CSM endonuclease III AQ980_22070 ENOG4105YAC AQ980_22075 ENOG4105DVT helicase AQ980_22090 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AQ980_22115 ENOG4105CPK Glycosyl transferase (Group 1 AQ980_22120 ENOG4105FJR Lmbe family AQ980_22135 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AQ980_22140 ENOG4108JYZ YitT family AQ980_22150 ENOG4105DQ6 Transposase AQ980_22185 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AQ980_22190 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) AQ980_22205 ENOG41068YB TPR repeat-containing protein AQ980_22225 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AQ980_22230 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AQ980_22235 ENOG4105EAH synthase AQ980_22245 ENOG4105XXQ heptaprenyl diphosphate synthase component I AQ980_22260 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AQ980_22290 ENOG41065D1 AQ980_22295 ENOG4105S2F AQ980_22310 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AQ980_22330 ENOG4107RB3 L-asparaginase AQ980_22335 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AQ980_22360 ENOG4108S6Z Negative regulator of genetic competence AQ980_22365 ENOG4108XDN Transcriptional regulator AQ980_22370 ENOG4107RGJ metallophosphoesterase AQ980_22380 ENOG4105I7S Abortive infection protein AQ980_22385 ENOG4105C9U ATP-dependent DNA helicase RecQ AQ980_22400 ENOG4108SAX Membrane AQ980_22415 ENOG4108WBT adenosyltransferase AQ980_22420 ENOG4105BZU Histidine kinase AQ980_22425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_22430 ENOG4105CRE cytochrome C AQ980_22435 ENOG4107TWT Cytochrome c biogenesis protein AQ980_22440 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AQ980_22445 ENOG4105FE9 pseudouridine synthase AQ980_22455 ENOG4108JIC nucleoside recognition domain protein AQ980_22460 ENOG4105DZ1 carboxypeptidase AQ980_22465 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AQ980_22495 ENOG4105BZU Histidine kinase AQ980_22510 ENOG4105I3N Conserved Protein AQ980_22515 ENOG4105BZU Histidine kinase AQ980_22530 ENOG4105BZ4 penicillin-binding protein AQ980_22535 ENOG4107GRR phosphate transport regulator AQ980_22540 ENOG4105CJ3 phosphate transporter AQ980_22565 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AQ980_22590 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AQ980_22610 ENOG4105WH1 Two component transcriptional regulator luxr family AQ980_22615 ENOG4105ENE Histidine kinase AQ980_22635 ENOG4105DFD Na H antiporter AQ980_22655 ENOG4105C8J )-transporter AQ980_22665 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AQ980_22670 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AQ980_22675 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AQ980_22685 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AQ980_22690 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AQ980_22695 ENOG4107S4M Sulfate adenylate transferase AQ980_22710 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AQ980_22720 ENOG4105E0M Sulfatase AQ980_22725 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AQ980_22740 ENOG4107RVV histidinol phosphate phosphatase, hisj family AQ980_22755 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AQ980_22760 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AQ980_22765 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AQ980_22770 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AQ980_22775 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AQ980_22780 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AQ980_22795 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AQ980_22810 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AQ980_22815 ENOG4108ZP8 Acetolactate synthase small subunit AQ980_22820 ENOG4105C7K acetolactate synthase AQ980_22825 ENOG4105CM2 brancheD-chain amino acid aminotransferase AQ980_22855 ENOG4105KBJ sporulation protein ytfj AQ980_22860 ENOG41063Y9 AQ980_22865 ENOG4105CZN Potassium uptake protein AQ980_22930 ENOG4105NQC Flavodoxin AQ980_22955 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AQ980_22965 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AQ980_22970 ENOG4105EA8 2-Nitropropane dioxygenase AQ980_22975 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AQ980_23015 ENOG4105CJ1 ABC, transporter AQ980_23025 ENOG4105CZV ABC transporter AQ980_23030 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AQ980_23045 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AQ980_23050 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AQ980_23100 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AQ980_23105 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AQ980_23110 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AQ980_23115 ENOG4105BZU Histidine kinase AQ980_23125 ENOG4106DF1 AQ980_23135 ENOG41090MY MarR family Transcriptional regulator AQ980_23140 ENOG4105BZU Histidine kinase AQ980_23150 ENOG4105PXI polysaccharide deacetylase AQ980_23160 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AQ980_23175 ENOG4105E98 transcriptional regulator DeoR family AQ980_23195 ENOG4107RCV ABC transporter, permease AQ980_23200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AQ980_23205 ENOG4105C4Y ABC transporter AQ980_23235 ENOG4105CHR reductase AQ980_23255 ENOG4108Z7G MaoC domain protein dehydratase AQ980_23260 ENOG410681C small acid-soluble spore protein AQ980_23265 ENOG4105CZN Potassium uptake protein AQ980_23270 ENOG4107TS3 membrane protein, TerC AQ980_23275 ENOG4108QTI )-transporter AQ980_23285 ENOG4106A3R peptidase AQ980_23305 ENOG4105JXH GntR family transcriptional regulator AQ980_23310 ENOG4105BZU Histidine kinase AQ980_23315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_23330 ENOG4105CQB FAD linked oxidase domain protein AQ980_23335 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AQ980_23340 ENOG4105K4I Scp-like extracellular AQ980_23350 ENOG4108YBP pseudouridine synthase AQ980_23360 ENOG4105EYF MMPL domain protein AQ980_23370 ENOG4107RUE extracellular solute-binding protein family 1 AQ980_23375 ENOG4105D38 putrescine abc transporter AQ980_23380 ENOG4105F38 ABC transporter, permease AQ980_23385 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AQ980_23390 ENOG4105C26 Dehydrogenase AQ980_23425 ENOG4105VFR signal peptidase AQ980_23430 ENOG4105DZ1 carboxypeptidase AQ980_23440 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AQ980_23460 ENOG4105RHA ABC transporter, permease AQ980_23465 ENOG4108IUX (ABC) transporter AQ980_23480 ENOG4105DQ6 Transposase AQ980_23515 ENOG4105VZ8 Transcriptional regulator AQ980_23520 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AQ980_23525 ENOG4105C7S Dehydrogenase AQ980_23545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AQ980_23550 ENOG4105DQ6 Transposase AQ980_23625 ENOG4105DK0 Indole-3-glycerol phosphate synthase AQ980_23635 ENOG4105DDQ anthranilate synthase AQ980_23640 ENOG4105CRQ synthase (Component I) AQ980_23650 ENOG4105CK7 Sodium proline symporter AQ980_23680 ENOG4108ZMI UPF0477 protein AQ980_23730 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AQ980_23740 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AQ980_23745 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AQ980_23765 ENOG4107TVC Glycosyl transferase, family 2 AQ980_23785 ENOG4105K64 Glycosyl transferase, family 2 AQ980_23805 ENOG4105EMS pseudouridine synthase AQ980_23810 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AQ980_23820 ENOG4106EFP UPF0738 protein AQ980_23825 ENOG4105MIX Adenylate cyclase AQ980_23830 ENOG4108Z18 K06886 hemoglobin AQ980_23845 ENOG4105DPN Oligoendopeptidase f AQ980_23855 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AQ980_23865 ENOG4108ZCF integral membrane protein AQ980_23890 ENOG4105UQX Mate efflux family protein AQ980_23895 ENOG4108JQ7 (ABC) transporter AQ980_23905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AQ980_23910 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AQ980_23930 ENOG4105C31 Tryptophanyl-tRNA synthetase AQ980_23950 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AQ980_23955 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AQ980_23980 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AQ980_23995 ENOG4108KP7 hydrolase AQ980_24005 ENOG41073B9 AQ980_24010 ENOG4107AYK membrAne AQ980_24020 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AQ980_24035 ENOG4105QNR S1 RNA binding domain protein AQ980_24040 ENOG4108VPT UPF0234 protein AQ980_24055 ENOG4105BZU Histidine kinase AQ980_24095 ENOG4105CH6 catalase AQ980_24100 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AQ980_24105 ENOG4105CAQ asparagine synthetase AQ980_24130 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AQ980_24135 ENOG4105XSJ toxin secretion phage lysis holin AQ980_24205 ENOG41085W3 Transposase AQ980_24240 ENOG41085W3 Transposase AQ980_24260 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AQ980_24355 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AQ980_24370 ENOG4105CAQ asparagine synthetase AQ980_24385 ENOG4105C8Y Acetylornithine aminotransferase AQ980_24395 ENOG4105ERH Fumarylacetoacetate hydrolase AQ980_24475 ENOG4105VEQ Cold shock protein AQ980_24495 ENOG4107QP3 malate synthase g AQ980_24505 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) AQ980_24510 ENOG4105C8Q Methyl-accepting chemotaxis AQ980_24515 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AQ980_24535 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ980_24550 ENOG41086D8 Transcriptional regulator AQ980_24555 ENOG4108AEY RNA polymerase sigma factor AQ980_24565 ENOG4107TVP HD domain protein AQ980_24570 ENOG4107RN3 metallophosphoesterase AQ980_24575 ENOG4105ENX hydrolase AQ980_24585 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) AQ980_24660 ENOG4108IJ6 ABC transporter AQ980_24665 ENOG4105ECW sulfate abc transporter AQ980_24670 ENOG4108I5D sulfate abc transporter AQ980_24675 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AQ980_24685 ENOG4105CEY Amp-dependent synthetase and ligase AQ980_24700 ENOG4105DF9 Lipoate-protein, ligase AQ980_24705 ENOG4108RQ5 Beta-lactamase domain-containing protein AQ980_24710 ENOG4106AXD AQ980_24720 ENOG4108MK9 spermidine N(1)-acetyltransferase AQ980_24750 ENOG4105ECB domain protein AQ980_24750 ENOG4105ECB domain protein AQ980_24765 ENOG4105NA0 Transcriptional regulator AQ980_24790 ENOG4105C1Q protoporphyrinogen oxidase AQ980_24795 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AQ980_24805 ENOG4105BZ4 penicillin-binding protein AQ980_24810 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AQ980_24815 ENOG4105CKV Membrane AQ980_24820 ENOG410905X membrane-flanked domain protein AQ980_24860 ENOG4105CKV Membrane AQ980_24865 ENOG410905X membrane-flanked domain protein AQ980_24895 ENOG4105K59 histidine triad (HIT) protein AQ980_24925 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AQ980_24930 ENOG4105EEM helicase AQ980_24935 ENOG4105CNI cell division protein FtsW AQ980_24945 ENOG4105EMN RNA polymerase sigma factor AQ980_24960 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AQ980_24975 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AQ980_24980 ENOG41067QW Transcriptional regulator AQ980_24985 ENOG4105F0F Oxalate decarboxylase AQ980_25045 ENOG4106D4I domain protein AQ980_25050 ENOG4107VRP DNA repair exonuclease AQ980_25070 ENOG4107QHE Choloylglycine hydrolase AQ980_25080 ENOG4105C6F GntR Family Transcriptional Regulator AQ980_25095 ENOG4105K8R UPF0145 protein AQ980_25120 ENOG4105BZU Histidine kinase AQ980_25125 ENOG4105BZU Histidine kinase AQ980_25130 ENOG4108MJI response regulator AQ980_25140 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AQ980_25150 ENOG4105WN5 stage II sporulation protein AQ980_25270 ENOG4105CMT Dihydroxyacetone kinase AQ980_25275 ENOG4108NIW Leucine export protein LeuE AQ980_25295 ENOG4105WAB arsR family transcriptional regulator AQ980_25300 ENOG4105F27 Major Facilitator AQ980_25305 ENOG4105DQ6 Transposase AQ980_25320 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AQ980_25375 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AQ980_25395 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AQ980_25425 ENOG4105F6J Alpha beta hydrolase fold AQ980_25440 ENOG4105EKQ RNA-directed DNA polymerase AQ980_25465 ENOG4107VUZ AQ980_25510 ENOG4105DQ6 Transposase AQ980_25525 ENOG4105D9U N-acetyltransferase AQ980_25540 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ980_25550 ENOG41087YS Phage shock protein A AQ980_25565 ENOG4108Z86 Glutamine amidotransferase AQ980_25590 ENOG4105CDU Replicative dna helicase AQ980_25605 ENOG4105CDU Replicative dna helicase AQ980_25620 ENOG4105M6F mutator MutT protein AQ980_25630 ENOG4108MRH transcriptional regulatory protein AQ980_25640 ENOG4105CSH Transporter AQ980_25695 ENOG4108IBT Inherit from COG: transposase AQ980_25720 ENOG4105DQ6 Transposase AQ980_25755 ENOG4108JQ7 (ABC) transporter AQ980_25765 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AQ980_25810 ENOG4105DER m42 family AQ980_25830 ENOG4105CGU Enoyl-CoA hydratase AQ980_25855 ENOG4105CHH sulfate transporter AQ980_25870 ENOG4105CEY Amp-dependent synthetase and ligase AQ980_25875 ENOG4105D4P Coproporphyrinogen iii oxidase AQ980_25880 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AQ980_25895 ENOG4108VX5 3-methyladenine DNA glycosylase AQ980_25905 ENOG4107FQX Alpha-acetolactate decarboxylase AQ980_25940 ENOG410839P AQ980_25955 ENOG4105CDA abc transporter atp-binding protein AQ980_25960 ENOG4105DRP amino acid AbC transporter AQ980_25970 ENOG4105BZ1 (ABC) transporter AQ980_25975 ENOG4105BZ1 (ABC) transporter AQ980_25985 ENOG4105C26 Dehydrogenase AQ980_25995 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AQ980_26000 ENOG4105D5Q Arginine ornithine antiporter AQ980_26010 ENOG4105CH6 catalase AQ980_26015 ENOG4107RKG DJ-1/PfpI family AQ980_26025 ENOG4105E5W Transporter AQ980_26030 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AQ980_26065 ENOG4105KPY Small multidrug resistance protein AQ980_26075 ENOG4105UBK short-chain dehydrogenase reductase AQ980_26080 ENOG4105CH7 arginosuccinase AQ980_26085 ENOG4108YXU transcriptional regulator AsnC family AQ980_26125 ENOG4106KNT transcriptional regulator AQ980_26135 ENOG4107RWR Sodium hydrogen exchanger AQ980_26140 ENOG4105CUB amino acid AQ980_26175 ENOG4107T5V SNARE associated Golgi AQ980_26210 ENOG4105WEF catalase AQ980_26240 ENOG4105C19 ABC transporter AQ980_26245 ENOG4107RBB ABC transporter, permease AQ980_26250 ENOG41069ER domain protein AQ980_26275 ENOG4105VZJ PTS System AQ980_26280 ENOG4105VCP PTS System AQ980_26285 ENOG4105EMD TRANSCRIPTIONal AQ980_26310 ENOG4108KGH TRANSCRIPTIONal AQ980_26320 ENOG41087NI Sulfite exporter TauE/SafE AQ980_26325 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase AQ980_26340 ENOG4105VFE sira family AQ980_26345 ENOG4107TPS domain protein AQ980_26350 ENOG4105VFE sira family AQ980_26355 ENOG4105XTG Pfam:DUF156 AQ980_26360 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase AQ980_26370 ENOG4108TCS Glutamyl endopeptidase AQ980_26380 ENOG4105ED1 spovr family AQ980_26385 ENOG4107Y03 Nitroreductase AQ980_26400 ENOG4105DQ6 Transposase AQ980_26415 ENOG4108B31 Spore germination protein AQ980_26435 ENOG4105K63 Thioredoxin AQ980_26450 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AQ980_26460 ENOG4105C7N Xanthine uracil vitamin C permease AQ980_26470 ENOG4105C19 ABC transporter AQ980_26545 ENOG4105DWF phosphomethylpyrimidine kinase AQ980_26550 ENOG4105D06 uba thif-type nad fad binding protein AQ980_26565 ENOG41080HI glycine oxidase AQ980_26570 ENOG4108VEU Thiamine monophosphate synthase AQ980_26580 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AQ980_26590 ENOG4105ETU transcriptional activator (TenA AQ980_26615 ENOG41080XQ Signal transduction protein with cbs domains AQ980_26740 ENOG4105E2Z phosphate ABC transporter (Permease AQ980_26745 ENOG4105C8U phosphate abc transporter AQ980_26750 ENOG4105CVA phosphate AQ980_26755 ENOG4105CE1 Ferrous iron transport protein b AQ980_26760 ENOG4105CE1 Ferrous iron transport protein b AQ980_26765 ENOG4105CE1 Ferrous iron transport protein b AQ980_26775 ENOG4108NHD germination protein AQ980_26790 ENOG4105E1V na solute symporter AQ980_26795 ENOG4106CAD Protein of unknown function (DUF3311) AQ980_26815 ENOG4105E2S oxidase) subunit II AQ980_26820 ENOG4105BZ9 Cytochrome C oxidase, subunit I AQ980_26825 ENOG4105CCU oxidase (Subunit III) AQ980_26845 ENOG4105MA6 gCN5-related N-acetyltransferase AQ980_26860 ENOG4105C7N Xanthine uracil vitamin C permease AQ980_26865 ENOG4105C85 amino acid AQ980_26885 ENOG4105DUX Transporter AQ980_26900 ENOG4107D63 AQ980_26905 ENOG4105VZ8 Transcriptional regulator AQ980_26910 ENOG41069ER domain protein AQ980_26915 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AQ980_26920 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AQ980_26960 ENOG4105CNU cell division protein FtsK AQ980_27050 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AQ980_27060 ENOG4105CAR Terminase, large subunit AQ980_27200 ENOG4108IMY Transcriptional regulator AQ980_27215 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) AQ980_27230 ENOG4105DQ6 Transposase AQ980_27265 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AQ980_27270 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AQ980_27275 ENOG4105CNN ABC, transporter AQ980_27280 ENOG4105C2J ABC transporter AQ980_27290 ENOG4108RVA ribokinase AQ980_27295 ENOG4105ETE Transcriptional regulator (LacI family AQ980_27300 ENOG4105C0R drug resistance transporter emrb qaca subfamily AQ980_27305 ENOG41067TZ transcriptional regulator, MarR family AQ980_27310 ENOG4105CXY transporter AQ980_27320 ENOG41068KF Universal stress protein AQ980_27330 ENOG4105CHH sulfate transporter AQ980_27345 ENOG4105BZU Histidine kinase AQ980_27350 ENOG4105NAE bifunctional deaminase-reductase domain protein AQ980_27355 ENOG4105D29 Helix-turn-helix type 11 domain protein AQ980_27365 ENOG4105GFR rna polymerase sigma factor AQ980_27380 ENOG4108IQI permease AQ980_27385 ENOG4105DRP amino acid AbC transporter AQ980_27390 ENOG4105EAD ABC transporter AQ980_27395 ENOG4105CT1 (ABC) transporter AQ980_27400 ENOG4105CDA abc transporter atp-binding protein AQ980_27410 ENOG4105BZG amino acid carrier protein AQ980_27415 ENOG4105CRN Aminoglycoside phosphotransferase AQ980_27420 ENOG4105E1K spore germination protein AQ980_27435 ENOG4105CG3 alpha amylase, catalytic region AQ980_27440 ENOG4105C5Y PTS System AQ980_27445 ENOG4107414 GntR family transcriptional regulator AQ980_27450 ENOG4105D5Q Arginine ornithine antiporter AQ980_27455 ENOG4105BZU Histidine kinase AQ980_27465 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AQ980_27470 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AQ980_27475 ENOG4107T89 von Willebrand factor, type A AQ980_27485 ENOG4105EXW epimerase dehydratase AQ980_27490 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AQ980_27495 ENOG4105DMQ Methyltransferase AQ980_27500 ENOG4105E0A ABC, transporter AQ980_27505 ENOG4108IHU transport system permease protein AQ980_27510 ENOG4105DQ5 transport system permease protein AQ980_27515 ENOG4108MES Periplasmic binding protein AQ980_27520 ENOG4105DUX Transporter AQ980_27545 ENOG4105DAA L-lactate AQ980_27550 ENOG4108IJ0 Aspartate ammonia-lyase AQ980_27555 ENOG4105C37 (CBS) domain AQ980_27560 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AQ980_27570 ENOG4105EKQ RNA-directed DNA polymerase AQ980_27585 ENOG4105D9N nucleoside AQ980_27590 ENOG4108KGH TRANSCRIPTIONal AQ980_27595 ENOG41073R8 VanW family AQ980_27630 ENOG4105DAP Nicotinate phosphoribosyltransferase AQ980_27635 ENOG4105C59 p-type ATPase AQ980_27650 ENOG4105CUB amino acid AQ980_27670 ENOG4108JB9 formate dehydrogenase AQ980_27675 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AQ980_27680 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) AQ980_27695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AQ980_27700 ENOG4105BZU Histidine kinase AQ980_27710 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AQ980_27715 ENOG4108UZ3 Transporter AQ980_27725 ENOG4105C6K Malic enzyme AQ980_27735 ENOG4108MRH transcriptional regulatory protein AQ980_27760 ENOG4105US7 Histidine kinase AQ980_27765 ENOG4108STX response regulator AQ980_27770 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AQ980_27775 ENOG4105BZ7 extracellular solute-binding protein family 1 AQ980_27780 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AQ980_27785 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AQ980_27790 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AQ980_27795 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AQ980_27820 ENOG4105D4T Citrate transporter AQ980_27825 ENOG4108V9W transcriptional regulatory protein AQ980_27830 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AQ980_27840 ENOG4105DZ6 Band 7 protein AQ980_27855 ENOG4105C94 Transporter AQ980_27875 ENOG4105CYN Serine protein kinase AQ980_27890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AQ980_27900 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AQ980_27910 ENOG4108R9S DSBA oxidoreductase AQ980_27915 ENOG4108JQC penicillin-binding protein 1A AQ980_27925 ENOG4105CDY transcriptional regulatory protein AQ980_28035 ENOG4105G5W regulator Fur family AQ980_28040 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AQ980_28060 ENOG4108IUW ABC transporter AQ980_28070 ENOG4105CBC glutamate synthase AQ980_28075 ENOG4107NBY Membrane AQ980_28080 ENOG4105BZ1 (ABC) transporter AQ980_28100 ENOG4106BXE AQ980_28105 ENOG4105CEN a g-specific adenine glycosylase AQ980_28110 ENOG41067AE Membrane-bound metal-dependent hydrolase AQ980_28140 ENOG4105ECP epimerase AQ980_28145 ENOG4105CI2 imidazolone-5-propionate hydrolase AQ980_28160 ENOG4108QBV Monogalactosyldiacylglycerol synthase AQ980_28165 ENOG4105F1A Pyruvate formate-lyase AQ980_28185 ENOG4105C3I Nad-dependent epimerase dehydratase AQ980_28190 ENOG4107QQG Dehydrogenase AQ980_28195 ENOG4105CKK Glycosyl transferase, family 2 AQ980_28210 ENOG4108A04 Beta-lactamase AQ980_28255 ENOG4108IQI permease AQ980_28265 ENOG4108JUB Transcriptional regulator AQ980_28275 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AQ980_28280 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AQ980_28315 ENOG4105UPD Calcium Proton AQ980_28320 ENOG410606W general stress protein AQ980_28335 ENOG4107ZTW SNARE associated Golgi AQ980_28360 ENOG4105C59 p-type ATPase AQ980_28365 ENOG4107U9T Pfam:Ribonuclease_BN AQ980_28375 ENOG4105KJF protein tyrosine phosphatase AQ980_28380 ENOG41068PA UPF0435 protein AQ980_28395 ENOG4108TTB tellurium resistance protein AQ980_28400 ENOG4107TS3 membrane protein, TerC AQ980_28405 ENOG4106FN3 tellurium resistance protein AQ980_28410 ENOG4106FN3 tellurium resistance protein AQ980_28415 ENOG4108N0M stress protein AQ980_28430 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AQ980_28445 ENOG4105DEU major facilitator superfamily AQ980_28460 ENOG41062JF Transcriptional regulator AQ980_28500 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AQ980_28520 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AQ980_28535 ENOG4105C9U ATP-dependent DNA helicase RecQ AQ980_28550 ENOG4105CI1 PTS System AQ980_28580 ENOG4108W63 CRP FNR family transcriptional regulator AQ980_28585 ENOG4105C5B carbamate kinase AQ980_28595 ENOG4105DBV ornithine carbamoyltransferase AQ980_28610 ENOG4105C8Q Methyl-accepting chemotaxis AQ980_28620 ENOG4105EAB amino acid AbC transporter AQ980_28625 ENOG4105E5Q amino acid AbC transporter AQ980_28650 ENOG4105D2S major facilitator superfamily AQ980_28655 ENOG410756H nucleotidyltransferase AQ980_28675 ENOG4105BZU Histidine kinase AQ980_28690 ENOG4106UIA AQ980_28695 ENOG4106UIA AQ980_28715 ENOG4105CAY ferredoxin--nadp reductase AQ980_28725 ENOG4108V5C ABC transporter AQ980_28730 ENOG4105DQ5 transport system permease protein AQ980_28735 ENOG4105EHG Permease protein AQ980_28740 ENOG4107W7X Aldolase AQ980_28745 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AQ980_28750 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AQ980_28755 ENOG4105D3R alkyl hydroperoxide reductase AQ980_28785 ENOG4105DTQ mandelate racemase muconate lactonizing AQ980_28800 ENOG4108W15 Protein of unknown function (DUF1456) AQ980_28810 ENOG4108FPN Integrase AQ980_28815 ENOG4108KU9 integrase family AQ980_28830 ENOG4107TSN permease AQ980_28915 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AQ980_28920 ENOG41085W3 Transposase AQ980_28930 ENOG4105CAR Terminase, large subunit AQ980_29065 ENOG4105KRN Transcriptional regulator, abrb family AQ980_29075 ENOG4106CVF DNA replication protein AQ980_29120 ENOG4105VTR Integrase AQ980_29125 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AQ980_29130 ENOG4105D9N nucleoside AQ980_29155 ENOG4105KPY Small multidrug resistance protein AQ980_29160 ENOG4105C26 Dehydrogenase AQ980_29170 ENOG4108JPW Aminotransferase AQ980_29175 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AQ980_29180 ENOG4105CBD Diacylglycerol kinase AQ980_29200 ENOG4107I77 yiaA/B two helix domain AQ980_29205 ENOG410834F Transcriptional regulator AQ980_29225 ENOG4105D01 (LipO)protein AQ980_29230 ENOG4108UMI ABC transporter, permease AQ980_29235 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AQ980_29240 ENOG4108W2Y isochorismatase AQ980_29260 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AQ980_29265 ENOG4105C4R Atp-dependent dna helicase AQ980_29295 ENOG4105C12 Phosphoribosylglycinamide synthetase AQ980_29305 ENOG4108V3E phosphoribosylglycinamide formyltransferase AQ980_29330 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AQ980_29340 ENOG4105C83 adenylosuccinate lyase AQ980_29345 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AQ980_29350 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AQ980_29385 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) AQ980_29435 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AQ980_29480 ENOG4107ZXU DSBA oxidoreductase AQ980_29505 ENOG4105BZU Histidine kinase AQ980_29515 ENOG4105C7N Xanthine uracil vitamin C permease AQ980_29525 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AQ980_29550 ENOG4105XSJ toxin secretion phage lysis holin AQ980_29620 ENOG4105EKQ RNA-directed DNA polymerase AQ980_29680 ENOG4105FB9 CRISPR-associated protein AQ980_29815 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AQ980_29820 ENOG4105VIZ double-strand break repair protein AQ980_29855 ENOG4105EKQ RNA-directed DNA polymerase AQ980_29865 ENOG4105EKQ RNA-directed DNA polymerase AQ980_29870 ENOG4105EKQ RNA-directed DNA polymerase AQ980_30025 ENOG4105EKQ RNA-directed DNA polymerase AQ980_30090 ENOG4105EKQ RNA-directed DNA polymerase AQ980_30100 ENOG4105EKQ RNA-directed DNA polymerase AQ980_30110 ENOG4105EKQ RNA-directed DNA polymerase AQ980_30155 ENOG4105DHF Membrane AQ980_30165 ENOG4108IBT Inherit from COG: transposase AQ980_30175 ENOG410780I phosphoprotein phosphatase activity AQ980_30200 ENOG4107V2S Transcriptional regulator AQ980_30205 ENOG4108WS4 fmn reductase AQ980_30250 ENOG4107TSN permease AQ980_30265 ENOG4108KU9 integrase family AQ980_30270 ENOG4108FPN Integrase AQ980_30275 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AQ980_30290 ENOG4105K70 DNA-binding protein AQ980_30305 ENOG4105KRN Transcriptional regulator, abrb family AQ980_30310 ENOG4108J59 Extracellular solute-binding protein, family 5 AQ980_30325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AQ980_30375 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving AQ980_30405 ENOG4105E1J oxidoreductase AQ980_30415 ENOG4107RT3 EamA-like transporter family AQ980_30425 ENOG4105EKQ RNA-directed DNA polymerase AQ980_30450 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AQ980_30490 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AQ980_30520 ENOG4105D7V transposase AQ980_30530 ENOG4105CHH sulfate transporter AQ980_30535 ENOG4107YZX Universal stress protein AQ980_30540 ENOG4105CN5 Metallo-Beta-Lactamase AQ980_30550 ENOG410900G Protein of unknown function (DUF421) AQ980_30560 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AQ980_30615 ENOG4105XSJ toxin secretion phage lysis holin AQ980_30655 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) AQ980_30805 ENOG4105CHH sulfate transporter AQ980_30815 ENOG410900G Protein of unknown function (DUF421) AQ980_30825 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AQ980_30885 ENOG4108IBT Inherit from COG: transposase AQ980_30960 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AQ980_31010 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AQ980_31165 ENOG4105K4H Nlp p60 protein AQ980_31175 ENOG410900G Protein of unknown function (DUF421) AQ980_31185 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AQ980_31410 ENOG4105DR5 peptidase AQ980_31555 ENOG4105K4H Nlp p60 protein AQ980_31630 ENOG4105CHH sulfate transporter AQ980_31700 ENOG4105C9U ATP-dependent DNA helicase RecQ AQ980_31730 ENOG4105DQ6 Transposase AQ980_31760 ENOG4108J59 Extracellular solute-binding protein, family 5 AQ980_32020 ENOG4105EKQ RNA-directed DNA polymerase AQ980_32070 ENOG4108IMY Transcriptional regulator AQ980_32190 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) AQ980_32245 ENOG4108TFU terminase (Small subunit) AQ980_32345 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase