locus-tag class description Bt4C1_00020 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Bt4C1_00055 ENOG4105ZMH deoxynucleoside kinase Bt4C1_00065 ENOG4105GTG Isochorismatase Bt4C1_00070 ENOG4108Z6B deaminase Bt4C1_00080 ENOG4105C6E dna polymerase iii Bt4C1_00100 ENOG41067KS pro-sigma K processing Bt4C1_00135 ENOG4105CXN decarboxylase Bt4C1_00145 ENOG4105FA2 dna polymerase iii Bt4C1_00150 ENOG4105MA4 psp1 domain protein Bt4C1_00160 ENOG41060K3 Methyltransferase Bt4C1_00170 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Bt4C1_00175 ENOG4105KRN Transcriptional regulator, abrb family Bt4C1_00180 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Bt4C1_00185 ENOG4105F8V Hydrolase, tatD family Bt4C1_00190 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) Bt4C1_00200 ENOG4105XFA sporulation peptidase YabG Bt4C1_00205 ENOG4105W42 Veg protein Bt4C1_00220 ENOG4105DFT pur operon repressor Bt4C1_00225 ENOG4105KME endoribonuclease L-psp Bt4C1_00240 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Bt4C1_00245 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Bt4C1_00255 ENOG4108JA2 transcriptioN-repair coupling factor Bt4C1_00260 ENOG4108M14 stage v sporulation protein t Bt4C1_00270 ENOG4108IY2 MazG family Bt4C1_00275 ENOG41082I2 s4 domain protein Bt4C1_00280 ENOG4105VYY sporulation protein yabp Bt4C1_00295 ENOG41060GV RNA binding s1 domain protein Bt4C1_00315 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Bt4C1_00320 ENOG4108UGV hypoxanthine phosphoribosyltransferase Bt4C1_00325 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Bt4C1_00340 ENOG4105C6T cysteine synthase Bt4C1_00345 ENOG4105CRQ synthase (Component I) Bt4C1_00350 ENOG4105DDQ anthranilate synthase Bt4C1_00355 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 Bt4C1_00360 ENOG4105EEI dihydropteroate synthase Bt4C1_00365 ENOG4105KRF dihydroneopterin aldolase Bt4C1_00370 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Bt4C1_00380 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Bt4C1_00410 ENOG4108Z0C Uvrb UvrC protein Bt4C1_00425 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Bt4C1_00435 ENOG4105CTP PilT protein domain protein Bt4C1_00455 ENOG4105D7W serine acetyltransferase Bt4C1_00470 ENOG4105C2N RNA methyltransferase TrmH family group 3 Bt4C1_00475 ENOG4105M0M Tetracycline resistance protein Bt4C1_00480 ENOG4105QIV RNA polymerase Bt4C1_00490 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Bt4C1_00515 ENOG4107Y49 methyltransferase Bt4C1_00525 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Bt4C1_00530 ENOG4105XPM ribosomal protein Bt4C1_00635 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Bt4C1_00660 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Bt4C1_00670 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Bt4C1_00680 ENOG41067V7 50S ribosomal protein L36 Bt4C1_00705 ENOG4108JJB ABC transporter Bt4C1_00710 ENOG4108JJB ABC transporter Bt4C1_00715 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Bt4C1_00720 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Bt4C1_00745 ENOG4105D1F ATP-binding protein Bt4C1_00760 ENOG4108NMV polysaccharide deacetylase Bt4C1_00840 ENOG4105C8B TIGR00159 family Bt4C1_00845 ENOG4107U5W ybbr family Bt4C1_00860 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Bt4C1_00880 ENOG4108PSK reductase Bt4C1_00885 ENOG4108UMI ABC transporter, permease Bt4C1_00890 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_00895 ENOG4105D01 (LipO)protein Bt4C1_00900 ENOG4105CB2 alcohol dehydrogenase Bt4C1_00910 ENOG4105IQ5 FAD linked oxidase domain protein Bt4C1_00925 ENOG4105C2C drug resistance transporter, Bcr CflA Bt4C1_00945 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Bt4C1_00950 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Bt4C1_00955 ENOG4105C3U ABC transporter Bt4C1_00960 ENOG4108JQ7 (ABC) transporter Bt4C1_00980 ENOG4108J59 Extracellular solute-binding protein, family 5 Bt4C1_00985 ENOG4108J59 Extracellular solute-binding protein, family 5 Bt4C1_01005 ENOG4105E0C molybdate abc transporter Bt4C1_01010 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Bt4C1_01015 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family Bt4C1_01035 ENOG4105F6E Acyl-transferase Bt4C1_01050 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) Bt4C1_01070 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) Bt4C1_01090 ENOG4105C5H ABC transporter Bt4C1_01100 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein Bt4C1_01110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Bt4C1_01115 ENOG4105C3U ABC transporter Bt4C1_01120 ENOG4108JQ7 (ABC) transporter Bt4C1_01125 ENOG410667J hydrolase Bt4C1_01160 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Bt4C1_01165 ENOG4105ERH Fumarylacetoacetate hydrolase Bt4C1_01175 ENOG4105CUB amino acid Bt4C1_01180 ENOG4108SC4 )-transporter Bt4C1_01185 ENOG4105CPF Cell wall formation (By similarity) Bt4C1_01190 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Bt4C1_01215 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein Bt4C1_01220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Bt4C1_01230 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) Bt4C1_01330 ENOG4105K8N protein family UPF0079, ATPase Bt4C1_01335 ENOG41072GX Peptidase M22 Glycoprotease Bt4C1_01340 ENOG410801F ribosomal-protein-alanine acetyltransferase Bt4C1_01345 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Bt4C1_01350 ENOG4105C5H ABC transporter Bt4C1_01365 ENOG4108TYN CAAX amino terminal protease family protein Bt4C1_01385 ENOG4105C7N Xanthine uracil vitamin C permease Bt4C1_01395 ENOG4105BZU Histidine kinase Bt4C1_01420 ENOG4107ZXU DSBA oxidoreductase Bt4C1_01465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Bt4C1_01485 ENOG410631K Membrane Bt4C1_01510 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) Bt4C1_01515 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Bt4C1_01520 ENOG4105C83 adenylosuccinate lyase Bt4C1_01530 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Bt4C1_01555 ENOG4108V3E phosphoribosylglycinamide formyltransferase Bt4C1_01565 ENOG4105C12 Phosphoribosylglycinamide synthetase Bt4C1_01590 ENOG4105C4R Atp-dependent dna helicase Bt4C1_01615 ENOG4108W2Y isochorismatase Bt4C1_01620 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_01625 ENOG4108UMI ABC transporter, permease Bt4C1_01630 ENOG4105D01 (LipO)protein Bt4C1_01645 ENOG410834F Transcriptional regulator Bt4C1_01650 ENOG4107I77 yiaA/B two helix domain Bt4C1_01670 ENOG4105CBD Diacylglycerol kinase Bt4C1_01680 ENOG4108JPW Aminotransferase Bt4C1_01690 ENOG4105C26 Dehydrogenase Bt4C1_01695 ENOG4105KPY Small multidrug resistance protein Bt4C1_01720 ENOG4105D9N nucleoside Bt4C1_01725 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Bt4C1_01735 ENOG4108W15 Protein of unknown function (DUF1456) Bt4C1_01750 ENOG4105DTQ mandelate racemase muconate lactonizing Bt4C1_01760 ENOG4105DFD Na H antiporter Bt4C1_01780 ENOG4105D3R alkyl hydroperoxide reductase Bt4C1_01785 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) Bt4C1_01790 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Bt4C1_01795 ENOG4107W7X Aldolase Bt4C1_01800 ENOG4105EHG Permease protein Bt4C1_01805 ENOG4105DQ5 transport system permease protein Bt4C1_01810 ENOG4108V5C ABC transporter Bt4C1_01830 ENOG4106UIA Bt4C1_01835 ENOG4106UIA Bt4C1_01850 ENOG4105BZU Histidine kinase Bt4C1_01870 ENOG410756H nucleotidyltransferase Bt4C1_01875 ENOG4105D2S major facilitator superfamily Bt4C1_01890 ENOG4105E5Q amino acid AbC transporter Bt4C1_01895 ENOG4105EAB amino acid AbC transporter Bt4C1_01900 ENOG4105CDA abc transporter atp-binding protein Bt4C1_01905 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_01920 ENOG4105DBV ornithine carbamoyltransferase Bt4C1_01930 ENOG4105C5B carbamate kinase Bt4C1_01935 ENOG4108W63 CRP FNR family transcriptional regulator Bt4C1_01945 ENOG4105DNP FAD linked oxidase domain protein Bt4C1_01955 ENOG4105CI1 PTS System Bt4C1_01970 ENOG4105C9U ATP-dependent DNA helicase RecQ Bt4C1_01985 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Bt4C1_02005 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Bt4C1_02010 ENOG4105D2X ABC transporter substrate-binding protein Bt4C1_02045 ENOG41062JF Transcriptional regulator Bt4C1_02060 ENOG4105DEU major facilitator superfamily Bt4C1_02090 ENOG4108N0M stress protein Bt4C1_02095 ENOG4106FN3 tellurium resistance protein Bt4C1_02100 ENOG4106FN3 tellurium resistance protein Bt4C1_02105 ENOG4107TS3 membrane protein, TerC Bt4C1_02110 ENOG4108TTB tellurium resistance protein Bt4C1_02125 ENOG41068PA UPF0435 protein Bt4C1_02130 ENOG4105KJF protein tyrosine phosphatase Bt4C1_02140 ENOG4107U9T Pfam:Ribonuclease_BN Bt4C1_02145 ENOG4105C59 p-type ATPase Bt4C1_02150 ENOG4108IPJ Membrane Bt4C1_02170 ENOG4107ZTW SNARE associated Golgi Bt4C1_02185 ENOG410606W general stress protein Bt4C1_02190 ENOG4105UPD Calcium Proton Bt4C1_02225 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Bt4C1_02235 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Bt4C1_02245 ENOG4108JUB Transcriptional regulator Bt4C1_02255 ENOG4108IQI permease Bt4C1_02280 ENOG4105CSV Glutaminase Bt4C1_02290 ENOG4108A04 Beta-lactamase Bt4C1_02305 ENOG4105CKK Glycosyl transferase, family 2 Bt4C1_02310 ENOG4107QQG Dehydrogenase Bt4C1_02315 ENOG4105C3I Nad-dependent epimerase dehydratase Bt4C1_02320 ENOG4105CKK Glycosyl transferase, family 2 Bt4C1_02330 ENOG4105F1A Pyruvate formate-lyase Bt4C1_02350 ENOG4105CI2 imidazolone-5-propionate hydrolase Bt4C1_02355 ENOG4105ECP epimerase Bt4C1_02385 ENOG41067AE Membrane-bound metal-dependent hydrolase Bt4C1_02390 ENOG4105CEN a g-specific adenine glycosylase Bt4C1_02395 ENOG4106BXE Bt4C1_02415 ENOG4105BZ1 (ABC) transporter Bt4C1_02420 ENOG4107NBY Membrane Bt4C1_02425 ENOG4105CBC glutamate synthase Bt4C1_02435 ENOG4108IUW ABC transporter Bt4C1_02455 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Bt4C1_02460 ENOG4105G5W regulator Fur family Bt4C1_02565 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Bt4C1_02655 ENOG4108JQC penicillin-binding protein 1A Bt4C1_02660 ENOG4108R9S DSBA oxidoreductase Bt4C1_02670 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Bt4C1_02680 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Bt4C1_02685 ENOG4105BZU Histidine kinase Bt4C1_02690 ENOG4105CYN Serine protein kinase Bt4C1_02705 ENOG4105C94 Transporter Bt4C1_02720 ENOG4105DZ6 Band 7 protein Bt4C1_02730 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism Bt4C1_02735 ENOG4108V9W transcriptional regulatory protein Bt4C1_02740 ENOG4105D4T Citrate transporter Bt4C1_02765 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Bt4C1_02770 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_02775 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Bt4C1_02780 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component Bt4C1_02785 ENOG4105BZ7 extracellular solute-binding protein family 1 Bt4C1_02790 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Bt4C1_02795 ENOG4108STX response regulator Bt4C1_02800 ENOG4105US7 Histidine kinase Bt4C1_02825 ENOG4108MRH transcriptional regulatory protein Bt4C1_02835 ENOG4105C6K Malic enzyme Bt4C1_02845 ENOG4108UZ3 Transporter Bt4C1_02850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_02860 ENOG4105BZU Histidine kinase Bt4C1_02885 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Bt4C1_02890 ENOG4108JB9 formate dehydrogenase Bt4C1_02910 ENOG4105CUB amino acid Bt4C1_02920 ENOG4105C59 p-type ATPase Bt4C1_02925 ENOG4105DAP Nicotinate phosphoribosyltransferase Bt4C1_02955 ENOG41073R8 VanW family Bt4C1_02960 ENOG4108KGH TRANSCRIPTIONal Bt4C1_02965 ENOG4105D9N nucleoside Bt4C1_02970 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase Bt4C1_02975 ENOG4105C37 (CBS) domain Bt4C1_02980 ENOG4108IJ0 Aspartate ammonia-lyase Bt4C1_02985 ENOG4105DAA L-lactate Bt4C1_03000 ENOG4105DUX Transporter Bt4C1_03005 ENOG4108MES Periplasmic binding protein Bt4C1_03010 ENOG4105DQ5 transport system permease protein Bt4C1_03015 ENOG4108IHU transport system permease protein Bt4C1_03020 ENOG4105E0A ABC, transporter Bt4C1_03035 ENOG4105EXW epimerase dehydratase Bt4C1_03045 ENOG4107T89 von Willebrand factor, type A Bt4C1_03050 ENOG4105GMT ATPase associated with various cellular activities aaa_5 Bt4C1_03055 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Bt4C1_03065 ENOG4105BZU Histidine kinase Bt4C1_03070 ENOG4105D5Q Arginine ornithine antiporter Bt4C1_03075 ENOG4107414 GntR family transcriptional regulator Bt4C1_03080 ENOG4105C5Y PTS System Bt4C1_03085 ENOG4105CG3 alpha amylase, catalytic region Bt4C1_03100 ENOG4105E1K spore germination protein Bt4C1_03110 ENOG4105CRN Aminoglycoside phosphotransferase Bt4C1_03115 ENOG4105BZG amino acid carrier protein Bt4C1_03125 ENOG4105CDA abc transporter atp-binding protein Bt4C1_03130 ENOG4105CT1 (ABC) transporter Bt4C1_03135 ENOG4105EAD ABC transporter Bt4C1_03140 ENOG4105DRP amino acid AbC transporter Bt4C1_03145 ENOG4108IQI permease Bt4C1_03160 ENOG4105GFR rna polymerase sigma factor Bt4C1_03170 ENOG4105D29 Helix-turn-helix type 11 domain protein Bt4C1_03175 ENOG4105NAE bifunctional deaminase-reductase domain protein Bt4C1_03180 ENOG4105BZU Histidine kinase Bt4C1_03205 ENOG4105CHH sulfate transporter Bt4C1_03210 ENOG41068KF Universal stress protein Bt4C1_03220 ENOG4105CXY transporter Bt4C1_03225 ENOG41067TZ transcriptional regulator, MarR family Bt4C1_03230 ENOG4105C0R drug resistance transporter emrb qaca subfamily Bt4C1_03235 ENOG4105ETE Transcriptional regulator (LacI family Bt4C1_03240 ENOG4108RVA ribokinase Bt4C1_03250 ENOG4105C2J ABC transporter Bt4C1_03255 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Bt4C1_03350 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) Bt4C1_03490 ENOG4105XSJ toxin secretion phage lysis holin Bt4C1_03520 ENOG4105C2J ABC transporter Bt4C1_03525 ENOG4105CNN ABC, transporter Bt4C1_03530 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Bt4C1_03535 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Bt4C1_03575 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) Bt4C1_03605 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Bt4C1_03610 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Bt4C1_03615 ENOG41069ER domain protein Bt4C1_03620 ENOG4105VZ8 Transcriptional regulator Bt4C1_03625 ENOG4107D63 Bt4C1_03640 ENOG4105DUX Transporter Bt4C1_03660 ENOG4105C85 amino acid Bt4C1_03665 ENOG4105C7N Xanthine uracil vitamin C permease Bt4C1_03680 ENOG4105MA6 gCN5-related N-acetyltransferase Bt4C1_03705 ENOG4105BZ9 Cytochrome C oxidase, subunit I Bt4C1_03710 ENOG4105E2S oxidase) subunit II Bt4C1_03730 ENOG4106CAD Protein of unknown function (DUF3311) Bt4C1_03735 ENOG4105E1V na solute symporter Bt4C1_03750 ENOG4108NHD germination protein Bt4C1_03755 ENOG4105CE1 Ferrous iron transport protein b Bt4C1_03760 ENOG4105CE1 Ferrous iron transport protein b Bt4C1_03765 ENOG4105CE1 Ferrous iron transport protein b Bt4C1_03770 ENOG4105CVA phosphate Bt4C1_03775 ENOG4105C8U phosphate abc transporter Bt4C1_03780 ENOG4105E2Z phosphate ABC transporter (Permease Bt4C1_03905 ENOG41080XQ Signal transduction protein with cbs domains Bt4C1_03925 ENOG4105ETU transcriptional activator (TenA Bt4C1_03935 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Bt4C1_03945 ENOG4108VEU Thiamine monophosphate synthase Bt4C1_03950 ENOG41080HI glycine oxidase Bt4C1_03965 ENOG4105D06 uba thif-type nad fad binding protein Bt4C1_03970 ENOG4105DWF phosphomethylpyrimidine kinase Bt4C1_04020 ENOG4108INS Transcriptional regulator Bt4C1_04035 ENOG4105C7N Xanthine uracil vitamin C permease Bt4C1_04045 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein Bt4C1_04060 ENOG4105K63 Thioredoxin Bt4C1_04080 ENOG4108B31 Spore germination protein Bt4C1_04100 ENOG4107Y03 Nitroreductase Bt4C1_04105 ENOG4105ED1 spovr family Bt4C1_04115 ENOG4105XTG Pfam:DUF156 Bt4C1_04120 ENOG4105VFE sira family Bt4C1_04125 ENOG4107TPS domain protein Bt4C1_04130 ENOG4105VFE sira family Bt4C1_04135 ENOG4105VFE sira family Bt4C1_04145 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase Bt4C1_04150 ENOG41087NI Sulfite exporter TauE/SafE Bt4C1_04160 ENOG4108KGH TRANSCRIPTIONal Bt4C1_04185 ENOG4105EMD TRANSCRIPTIONal Bt4C1_04190 ENOG4105VCP PTS System Bt4C1_04195 ENOG4105VZJ PTS System Bt4C1_04220 ENOG41069ER domain protein Bt4C1_04225 ENOG4107RBB ABC transporter, permease Bt4C1_04230 ENOG4105C19 ABC transporter Bt4C1_04260 ENOG4105WEF catalase Bt4C1_04295 ENOG4107T5V SNARE associated Golgi Bt4C1_04325 ENOG4105CUB amino acid Bt4C1_04330 ENOG4107RWR Sodium hydrogen exchanger Bt4C1_04340 ENOG4106KNT transcriptional regulator Bt4C1_04380 ENOG4108YXU transcriptional regulator AsnC family Bt4C1_04390 ENOG4105UBK short-chain dehydrogenase reductase Bt4C1_04395 ENOG4105W1Y Transcriptional regulator Bt4C1_04400 ENOG4105KPY Small multidrug resistance protein Bt4C1_04425 ENOG4105DQ6 Transposase Bt4C1_04450 ENOG4107RKG DJ-1/PfpI family Bt4C1_04455 ENOG4105CH6 catalase Bt4C1_04465 ENOG4105D5Q Arginine ornithine antiporter Bt4C1_04470 ENOG4105C26 Dehydrogenase Bt4C1_04475 ENOG4105BZ1 (ABC) transporter Bt4C1_04480 ENOG4105BZ1 (ABC) transporter Bt4C1_04490 ENOG4105DRP amino acid AbC transporter Bt4C1_04495 ENOG4105CDA abc transporter atp-binding protein Bt4C1_04510 ENOG410839P Bt4C1_04545 ENOG4107FQX Alpha-acetolactate decarboxylase Bt4C1_04565 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Bt4C1_04570 ENOG4105D4P Coproporphyrinogen iii oxidase Bt4C1_04585 ENOG4105CHH sulfate transporter Bt4C1_04610 ENOG4105CGU Enoyl-CoA hydratase Bt4C1_04630 ENOG4105DER m42 family Bt4C1_04650 ENOG4105CTU Proline racemase Bt4C1_04655 ENOG4105CIF Ornithine Cyclodeaminase Bt4C1_04670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Bt4C1_04680 ENOG4108JQ7 (ABC) transporter Bt4C1_04710 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Bt4C1_04725 ENOG4105D06 uba thif-type nad fad binding protein Bt4C1_04730 ENOG4107SFI Major Facilitator superfamily Bt4C1_04760 ENOG4105DQ6 Transposase Bt4C1_04780 ENOG4108IBT Inherit from COG: transposase Bt4C1_04835 ENOG4105CSH Transporter Bt4C1_04845 ENOG4108MRH transcriptional regulatory protein Bt4C1_04905 ENOG4105CDU Replicative dna helicase Bt4C1_04935 ENOG4105C0R drug resistance transporter emrb qaca subfamily Bt4C1_04950 ENOG4105D9U N-acetyltransferase Bt4C1_04975 ENOG4105F6J Alpha beta hydrolase fold Bt4C1_05025 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Bt4C1_05035 ENOG4105F27 Major Facilitator Bt4C1_05040 ENOG4105WAB arsR family transcriptional regulator Bt4C1_05050 ENOG4105CMT Dihydroxyacetone kinase Bt4C1_05070 ENOG410847I Transcriptional regulator, BadM Rrf2 family Bt4C1_05150 ENOG4105WN5 stage II sporulation protein Bt4C1_05160 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Bt4C1_05170 ENOG4108MJI response regulator Bt4C1_05175 ENOG4105BZU Histidine kinase Bt4C1_05180 ENOG4105BZU Histidine kinase Bt4C1_05215 ENOG4105EKQ RNA-directed DNA polymerase Bt4C1_05225 ENOG4107QHE Choloylglycine hydrolase Bt4C1_05245 ENOG4107VRP DNA repair exonuclease Bt4C1_05250 ENOG4106D4I domain protein Bt4C1_05260 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Bt4C1_05290 ENOG4106050 phage regulatory protein, rha family Bt4C1_05360 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) Bt4C1_05550 ENOG410829K Lysine exporter protein (Lyse ygga) Bt4C1_05575 ENOG4108MUZ hydrolase Bt4C1_05590 ENOG4105F0F Oxalate decarboxylase Bt4C1_05595 ENOG41067QW Transcriptional regulator Bt4C1_05600 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator Bt4C1_05615 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Bt4C1_05630 ENOG4105EMN RNA polymerase sigma factor Bt4C1_05640 ENOG4105CNI cell division protein FtsW Bt4C1_05645 ENOG4105EEM helicase Bt4C1_05655 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Bt4C1_05680 ENOG4105K59 histidine triad (HIT) protein Bt4C1_05710 ENOG410905X membrane-flanked domain protein Bt4C1_05715 ENOG4105CKV Membrane Bt4C1_05755 ENOG410905X membrane-flanked domain protein Bt4C1_05760 ENOG4105CKV Membrane Bt4C1_05765 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation Bt4C1_05770 ENOG4105BZ4 penicillin-binding protein Bt4C1_05780 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Bt4C1_05785 ENOG4105C1Q protoporphyrinogen oxidase Bt4C1_05815 ENOG4105ECB domain protein Bt4C1_05845 ENOG4106AXD Bt4C1_05850 ENOG4108RQ5 Beta-lactamase domain-containing protein Bt4C1_05855 ENOG4105DF9 Lipoate-protein, ligase Bt4C1_05865 ENOG4105CEY Amp-dependent synthetase and ligase Bt4C1_05890 ENOG4105ST3 Transcriptional regulator Bt4C1_05895 ENOG4105ENX hydrolase Bt4C1_05900 ENOG4107RN3 metallophosphoesterase Bt4C1_05905 ENOG4107TVP HD domain protein Bt4C1_05915 ENOG4108AEY RNA polymerase sigma factor Bt4C1_05920 ENOG41086D8 Transcriptional regulator Bt4C1_05955 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 Bt4C1_05960 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_05970 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) Bt4C1_05980 ENOG4107QP3 malate synthase g Bt4C1_06000 ENOG4105VEQ Cold shock protein Bt4C1_06015 ENOG4105XVF Competence transcription factor Bt4C1_06080 ENOG4105ERH Fumarylacetoacetate hydrolase Bt4C1_06090 ENOG4105C8Y Acetylornithine aminotransferase Bt4C1_06105 ENOG4105CAQ asparagine synthetase Bt4C1_06110 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Bt4C1_06115 ENOG4105CH6 catalase Bt4C1_06120 ENOG4105BZU Histidine kinase Bt4C1_06140 ENOG4105QNR S1 RNA binding domain protein Bt4C1_06145 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Bt4C1_06150 ENOG4107AYK membrAne Bt4C1_06155 ENOG41073B9 Bt4C1_06165 ENOG4108KP7 hydrolase Bt4C1_06175 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Bt4C1_06200 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Bt4C1_06205 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Bt4C1_06225 ENOG4105C31 Tryptophanyl-tRNA synthetase Bt4C1_06240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Bt4C1_06245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Bt4C1_06255 ENOG4108JQ7 (ABC) transporter Bt4C1_06260 ENOG4105UQX Mate efflux family protein Bt4C1_06280 ENOG4108ZCF integral membrane protein Bt4C1_06290 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Bt4C1_06300 ENOG4105DPN Oligoendopeptidase f Bt4C1_06310 ENOG4108Z18 K06886 hemoglobin Bt4C1_06315 ENOG4105MIX Adenylate cyclase Bt4C1_06330 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Bt4C1_06335 ENOG4105EMS pseudouridine synthase Bt4C1_06355 ENOG4105K64 Glycosyl transferase, family 2 Bt4C1_06375 ENOG4107TVC Glycosyl transferase, family 2 Bt4C1_06395 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Bt4C1_06400 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Bt4C1_06410 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase Bt4C1_06485 ENOG4105CK7 Sodium proline symporter Bt4C1_06490 ENOG4105CRQ synthase (Component I) Bt4C1_06495 ENOG4105DDQ anthranilate synthase Bt4C1_06595 ENOG4105C7S Dehydrogenase Bt4C1_06605 ENOG4105VZ8 Transcriptional regulator Bt4C1_06630 ENOG4108IUX (ABC) transporter Bt4C1_06635 ENOG4105RHA ABC transporter, permease Bt4C1_06665 ENOG4105DZ1 carboxypeptidase Bt4C1_06670 ENOG4105VFR signal peptidase Bt4C1_06705 ENOG4105C26 Dehydrogenase Bt4C1_06710 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_06715 ENOG4105F38 ABC transporter, permease Bt4C1_06720 ENOG4105D38 putrescine abc transporter Bt4C1_06725 ENOG4107RUE extracellular solute-binding protein family 1 Bt4C1_06730 ENOG410841Q phosphoesterase PA-phosphatase related protein Bt4C1_06735 ENOG4105EYF MMPL domain protein Bt4C1_06745 ENOG4108YBP pseudouridine synthase Bt4C1_06755 ENOG4105K4I Scp-like extracellular Bt4C1_06760 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Bt4C1_06765 ENOG4105CQB FAD linked oxidase domain protein Bt4C1_06780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_06785 ENOG4105BZU Histidine kinase Bt4C1_06790 ENOG4105JXH GntR family transcriptional regulator Bt4C1_06810 ENOG4106A3R peptidase Bt4C1_06820 ENOG4108QTI )-transporter Bt4C1_06825 ENOG4107TS3 membrane protein, TerC Bt4C1_06830 ENOG4105CZN Potassium uptake protein Bt4C1_06835 ENOG410681C small acid-soluble spore protein Bt4C1_06840 ENOG4108Z7G MaoC domain protein dehydratase Bt4C1_06860 ENOG4105CHR reductase Bt4C1_06890 ENOG4105C4Y ABC transporter Bt4C1_06895 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_06900 ENOG4107RCV ABC transporter, permease Bt4C1_06920 ENOG4105E98 transcriptional regulator DeoR family Bt4C1_06935 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) Bt4C1_06945 ENOG4105PXI polysaccharide deacetylase Bt4C1_06955 ENOG4105BZU Histidine kinase Bt4C1_06960 ENOG41090MY MarR family Transcriptional regulator Bt4C1_06970 ENOG4106DF1 Bt4C1_06980 ENOG4105BZU Histidine kinase Bt4C1_06990 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase Bt4C1_06995 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Bt4C1_07035 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Bt4C1_07040 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Bt4C1_07045 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Bt4C1_07050 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_07055 ENOG4105CZV ABC transporter Bt4C1_07065 ENOG4105CJ1 ABC, transporter Bt4C1_07080 ENOG4105DQ6 Transposase Bt4C1_07115 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A Bt4C1_07120 ENOG4105EA8 2-Nitropropane dioxygenase Bt4C1_07125 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD Bt4C1_07135 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein Bt4C1_07160 ENOG4105NQC Flavodoxin Bt4C1_07200 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Bt4C1_07230 ENOG4105CZN Potassium uptake protein Bt4C1_07235 ENOG41063Y9 Bt4C1_07240 ENOG4105KBJ sporulation protein ytfj Bt4C1_07260 ENOG4105CM2 brancheD-chain amino acid aminotransferase Bt4C1_07265 ENOG4105C7K acetolactate synthase Bt4C1_07270 ENOG4108ZP8 Acetolactate synthase small subunit Bt4C1_07275 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Bt4C1_07310 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Bt4C1_07345 ENOG4107RVV histidinol phosphate phosphatase, hisj family Bt4C1_07360 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase Bt4C1_07365 ENOG4105E0M Sulfatase Bt4C1_07375 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Bt4C1_07395 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) Bt4C1_07400 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Bt4C1_07410 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Bt4C1_07415 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein Bt4C1_07420 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein Bt4C1_07425 ENOG4105C8J )-transporter Bt4C1_07445 ENOG4105DFD Na H antiporter Bt4C1_07465 ENOG4105ENE Histidine kinase Bt4C1_07470 ENOG4105WH1 Two component transcriptional regulator luxr family Bt4C1_07485 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Bt4C1_07510 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Bt4C1_07530 ENOG4105CJ3 phosphate transporter Bt4C1_07535 ENOG4107GRR phosphate transport regulator Bt4C1_07540 ENOG4105BZ4 penicillin-binding protein Bt4C1_07555 ENOG4105BZU Histidine kinase Bt4C1_07560 ENOG4105I3N Conserved Protein Bt4C1_07575 ENOG4105BZU Histidine kinase Bt4C1_07605 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Bt4C1_07610 ENOG4105DZ1 carboxypeptidase Bt4C1_07615 ENOG4108JIC nucleoside recognition domain protein Bt4C1_07625 ENOG4105FE9 pseudouridine synthase Bt4C1_07630 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Bt4C1_07635 ENOG4107TWT Cytochrome c biogenesis protein Bt4C1_07640 ENOG4105CRE cytochrome C Bt4C1_07645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_07650 ENOG4105BZU Histidine kinase Bt4C1_07655 ENOG4108WBT adenosyltransferase Bt4C1_07660 ENOG41063SB peptidase Bt4C1_07670 ENOG4108SAX Membrane Bt4C1_07685 ENOG4105C9U ATP-dependent DNA helicase RecQ Bt4C1_07690 ENOG4105I7S Abortive infection protein Bt4C1_07700 ENOG4107RGJ metallophosphoesterase Bt4C1_07705 ENOG4108XDN Transcriptional regulator Bt4C1_07710 ENOG4108S6Z Negative regulator of genetic competence Bt4C1_07735 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase Bt4C1_07740 ENOG4107RB3 L-asparaginase Bt4C1_07770 ENOG4105S2F Bt4C1_07775 ENOG41065D1 Bt4C1_07805 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) Bt4C1_07820 ENOG4105XXQ heptaprenyl diphosphate synthase component I Bt4C1_07830 ENOG4105EAH synthase Bt4C1_07835 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Bt4C1_07840 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Bt4C1_07855 ENOG41068YB TPR repeat-containing protein Bt4C1_07870 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) Bt4C1_07875 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Bt4C1_07910 ENOG4108JYZ YitT family Bt4C1_07915 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase Bt4C1_07930 ENOG4105FJR Lmbe family Bt4C1_07935 ENOG4105CPK Glycosyl transferase (Group 1 Bt4C1_07970 ENOG4105DVT helicase Bt4C1_07975 ENOG4105YAC Bt4C1_07995 ENOG4105CSM endonuclease III Bt4C1_08005 ENOG4105BZ4 penicillin-binding protein Bt4C1_08060 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Bt4C1_08070 ENOG4105DVT helicase Bt4C1_08075 ENOG4105CTD carboxy-peptidase Bt4C1_08095 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Bt4C1_08105 ENOG4105C2W permease Bt4C1_08110 ENOG4105DHF Membrane Bt4C1_08115 ENOG410890F Dynamin family Bt4C1_08125 ENOG4108W0I acetyltransferase Bt4C1_08135 ENOG4105KHC sulfurtransferase Bt4C1_08160 ENOG4106032 Glutathionylspermidine synthase Bt4C1_08220 ENOG4105CPK Glycosyl transferase (Group 1 Bt4C1_08235 ENOG4108SZE gCN5-related N-acetyltransferase Bt4C1_08255 ENOG41081VK Ribonuclease Bt4C1_08320 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Bt4C1_08330 ENOG4107RWR Sodium hydrogen exchanger Bt4C1_08335 ENOG4105CN5 Metallo-Beta-Lactamase Bt4C1_08340 ENOG4108Z5V transcriptional regulator, merr family Bt4C1_08350 ENOG4105H67 Protein of unknown function (DUF421) Bt4C1_08355 ENOG41080C8 DUF218 domain Bt4C1_08390 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Bt4C1_08400 ENOG4107R0U MotA TolQ exbB proton channel Bt4C1_08405 ENOG4105ER2 Ompa motb domain protein Bt4C1_08410 ENOG4107YTP response regulator receiver protein Bt4C1_08415 ENOG4105CBS Chea signal transduction histidine kinase Bt4C1_08420 ENOG4105DD5 Flagellar motor switch protein Bt4C1_08435 ENOG4105BZU Histidine kinase Bt4C1_08455 ENOG4105E1Q flagellar hook-associated protein Bt4C1_08460 ENOG4105DTJ flagellar hook-associated protein Bt4C1_08480 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) Bt4C1_08485 ENOG4108ZC9 flagellar basal-body rod protein flgc Bt4C1_08490 ENOG41075Z6 flagellar hook-basal body complex protein fliE Bt4C1_08495 ENOG4107U2N Flagellar M-ring protein Bt4C1_08500 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Bt4C1_08530 ENOG4105BZE flagellar hook protein, FlgE Bt4C1_08545 ENOG4107R88 Chemotaxis protein (CheV) Bt4C1_08555 ENOG4105I03 Flagellin Bt4C1_08560 ENOG4105I03 Flagellin Bt4C1_08565 ENOG4105I03 Flagellin Bt4C1_08570 ENOG4105I03 Flagellin Bt4C1_08575 ENOG4105E4C Lytic transglycosylase catalytic Bt4C1_08585 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Bt4C1_08590 ENOG4105DD5 Flagellar motor switch protein Bt4C1_08600 ENOG4105CN7 Flagellar biosynthetic protein FliP Bt4C1_08605 ENOG4105VS8 Flagellar biosynthetic protein fliq Bt4C1_08615 ENOG4105D00 flagellar biosynthetic protein flhB Bt4C1_08620 ENOG4105D7B Flagellar biosynthesis protein flha Bt4C1_08625 ENOG4105FZW flagellar biosynthesis regulator FlhF Bt4C1_08630 ENOG4105KTQ flagellar basal-body rod protein Bt4C1_08635 ENOG4105CPU Monooxygenase Bt4C1_08640 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Bt4C1_08670 ENOG4105KAC Antibiotic biosynthesis monooxygenase Bt4C1_08700 ENOG4105DUM transcriptional regulator, lysR family Bt4C1_08705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_08715 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component Bt4C1_08720 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Bt4C1_08750 ENOG4105CVJ phosphoglycerate mutase Bt4C1_08760 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Bt4C1_08770 ENOG4105K56 Transcriptional regulator Bt4C1_08780 ENOG4105CAQ asparagine synthetase Bt4C1_08800 ENOG4105PGM cation diffusion facilitator family transporter Bt4C1_08815 ENOG4105CKI cobalamin synthesis protein Bt4C1_08820 ENOG4108PJD permease Bt4C1_08835 ENOG4105DFD Na H antiporter Bt4C1_08840 ENOG4105VUF Transcriptional regulator Bt4C1_08850 ENOG4105C9Q fumarate hydratase class II Bt4C1_08870 ENOG4107QJQ Mate efflux family protein Bt4C1_08875 ENOG4105EC3 peptidase S51, dipeptidase E Bt4C1_08895 ENOG4107QIV Cytochrome c biogenesis protein Bt4C1_08900 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Bt4C1_08910 ENOG4107JM4 Tetratricopeptide repeat Bt4C1_08930 ENOG4106BRA Membrane Bt4C1_08965 ENOG4105CJ1 ABC, transporter Bt4C1_08985 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Bt4C1_08995 ENOG4108IJ0 Aspartate ammonia-lyase Bt4C1_09000 ENOG4105C6K Malic enzyme Bt4C1_09055 ENOG4105FVX Bt4C1_09065 ENOG4105CSR polyphosphate kinase 2 Bt4C1_09070 ENOG4105U3E Transcriptional regulator Bt4C1_09080 ENOG4105DXI Major Facilitator superfamily Bt4C1_09090 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Bt4C1_09095 ENOG4105EU0 Major facilitator Superfamily Bt4C1_09100 ENOG4105C6T cysteine synthase Bt4C1_09120 ENOG4105C8J )-transporter Bt4C1_09130 ENOG4105X5K response regulator receiver protein Bt4C1_09135 ENOG4105H67 Protein of unknown function (DUF421) Bt4C1_09155 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Bt4C1_09160 ENOG4105CHR reductase Bt4C1_09165 ENOG4105CM2 brancheD-chain amino acid aminotransferase Bt4C1_09170 ENOG4105C7K acetolactate synthase Bt4C1_09180 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Bt4C1_09190 ENOG4105C7B Threonine dehydratase Bt4C1_09215 ENOG4105C6X Major Facilitator Bt4C1_09220 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Bt4C1_09235 ENOG4105DY9 regulatoR Bt4C1_09240 ENOG4105CYC Transferase Bt4C1_09265 ENOG41068WN Bt4C1_09285 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) Bt4C1_09300 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Bt4C1_09310 ENOG4105C0X amino acid Bt4C1_09345 ENOG410849A acetyltransferase, (GNAT) family Bt4C1_09350 ENOG4105K8R UPF0145 protein Bt4C1_09365 ENOG4107RHR regulatoR Bt4C1_09375 ENOG4105D9N nucleoside Bt4C1_09380 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) Bt4C1_09385 ENOG4105KG3 cytidine deaminase Bt4C1_09395 ENOG4105DQ6 Transposase Bt4C1_09410 ENOG4108IBT Inherit from COG: transposase Bt4C1_09440 ENOG4107RAQ aminopeptidase Bt4C1_09450 ENOG4107R16 Multicopper oxidase Bt4C1_09490 ENOG4108T5E Copper resistance protein Bt4C1_09495 ENOG4105KTB nuclear export factor GLE1 Bt4C1_09500 ENOG4107RT3 EamA-like transporter family Bt4C1_09505 ENOG4105GZI Transcriptional regulator Bt4C1_09510 ENOG4108Z40 Transcriptional regulator Bt4C1_09515 ENOG4107ZXU DSBA oxidoreductase Bt4C1_09520 ENOG4108TVJ Nitroreductase Bt4C1_09530 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Bt4C1_09535 ENOG4106F5Q Membrane Bt4C1_09540 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Bt4C1_09550 ENOG4105CKI cobalamin synthesis protein Bt4C1_09560 ENOG4105C0Z ABC transporter Bt4C1_09565 ENOG4108IV0 ABC, transporter Bt4C1_09570 ENOG4105C32 Amino acid ABC transporter (Permease) Bt4C1_09580 ENOG4105EGI Transcriptional regulator Bt4C1_09590 ENOG4105MDS 4-oxalocrotonate tautomerase Bt4C1_09610 ENOG4105C4M (Ubiquinol oxidase) subunit I Bt4C1_09615 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Bt4C1_09620 ENOG4108JJ9 ABC, transporter Bt4C1_09625 ENOG4108JJ8 (ABC) transporter Bt4C1_09635 ENOG4105K64 Glycosyl transferase, family 2 Bt4C1_09645 ENOG4108UT6 Transferase hexapeptide repeat containing protein Bt4C1_09700 ENOG4105BZ1 (ABC) transporter Bt4C1_09705 ENOG4105EFI regulatoR Bt4C1_09710 ENOG4105BZU Histidine kinase Bt4C1_09735 ENOG4108ZJ4 polysaccharide deacetylase Bt4C1_09755 ENOG4105D6E homoserine dehydrogenase Bt4C1_09780 ENOG4108KGH TRANSCRIPTIONal Bt4C1_09795 ENOG4105KT7 mgtC SapB transporter Bt4C1_09810 ENOG4105DUU IucA IucC family protein Bt4C1_09815 ENOG4105CEY Amp-dependent synthetase and ligase Bt4C1_09830 ENOG4108WBH protein TIM barrel Bt4C1_09835 ENOG4105YWU small acid-soluble spore protein Bt4C1_09845 ENOG4108ZUB Lysine exporter protein (Lyse ygga) Bt4C1_09850 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_09895 ENOG4105KRN Transcriptional regulator, abrb family Bt4C1_09905 ENOG4105YVS arsR family transcriptional regulator Bt4C1_09910 ENOG4105CPC Aldo Keto reductase Bt4C1_09940 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_09955 ENOG4108K88 Membrane Bt4C1_09960 ENOG4108WPJ Ferritin-like domain Bt4C1_09975 ENOG4105DEN Luciferase family Bt4C1_09990 ENOG4105VMI -acetyltransferase Bt4C1_09995 ENOG4107QM2 Aldo Keto reductase Bt4C1_10000 ENOG4105CKI cobalamin synthesis protein Bt4C1_10010 ENOG4105DSE periplasmic solute binding protein Bt4C1_10020 ENOG4105K4T epimerase Bt4C1_10030 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Bt4C1_10055 ENOG4105CVJ phosphoglycerate mutase Bt4C1_10075 ENOG4107T5V SNARE associated Golgi Bt4C1_10090 ENOG4108PJD permease Bt4C1_10100 ENOG4108S4H thioesterase Superfamily protein Bt4C1_10105 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Bt4C1_10125 ENOG4105SXS Protein of unknown function (DUF456) Bt4C1_10130 ENOG4105C37 (CBS) domain Bt4C1_10160 ENOG4108Z7R Chaperone CsaA Bt4C1_10175 ENOG4108ZRV stage ii sporulation protein p Bt4C1_10185 ENOG4108VXD carboxy-peptidase Bt4C1_10215 ENOG4108ZRV stage ii sporulation protein p Bt4C1_10225 ENOG4108X4Q Hydrolase Bt4C1_10230 ENOG41082F9 transcriptional regulator Bt4C1_10235 ENOG4105D94 Major Facilitator Superfamily Bt4C1_10245 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Bt4C1_10250 ENOG4107RBS Methyltransferase Bt4C1_10265 ENOG41087PP glycosyltransferase MGT family Bt4C1_10270 ENOG4108JYZ YitT family Bt4C1_10275 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_10305 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Bt4C1_10325 ENOG4106PAW secretion accessory protein EsaA YueB Bt4C1_10335 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) Bt4C1_10435 ENOG4105KBJ sporulation protein ytfj Bt4C1_10460 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Bt4C1_10480 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) Bt4C1_10485 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Bt4C1_10495 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Bt4C1_10500 ENOG4105EMN RNA polymerase sigma factor Bt4C1_10510 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Bt4C1_10520 ENOG4105CNW domain protein Bt4C1_10530 ENOG4108V06 Glutathione peroxidase Bt4C1_10545 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Bt4C1_10555 ENOG4108IUE nitrate reductase beta subunit Bt4C1_10560 ENOG4105R3A Nitrate reductase Bt4C1_10570 ENOG4107V6Q Cyclic nucleotide-binding domain Bt4C1_10575 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Bt4C1_10580 ENOG4105D06 uba thif-type nad fad binding protein Bt4C1_10585 ENOG4105CVM Molybdenum cofactor synthesis domain protein Bt4C1_10590 ENOG4108ZAF Molybdopterin Bt4C1_10615 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein Bt4C1_10620 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein Bt4C1_10625 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Bt4C1_10630 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit Bt4C1_10635 ENOG4108IFG nitrite reductase, (NAD(P)H) Bt4C1_10640 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) Bt4C1_10675 ENOG4105MCT stage V sporulation protein S Bt4C1_10710 ENOG4105C5H ABC transporter Bt4C1_10725 ENOG4108UUM single-stranded DNA-binding protein Bt4C1_10755 ENOG4107YX5 Pfam:DUF548 Bt4C1_10760 ENOG4105C75 arginyL-tRNA synthetase Bt4C1_10780 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Bt4C1_10795 ENOG4105C5S asparaginyl-tRNA synthetase Bt4C1_10800 ENOG4105C8J )-transporter Bt4C1_10805 ENOG4108EF6 Proline imino-peptidase Bt4C1_10820 ENOG4107XGZ Hydrolase Bt4C1_10825 ENOG4105CY2 Citrate transporter Bt4C1_10845 ENOG4105KD7 acetyltransferase Bt4C1_10855 ENOG4105VMP Transcriptional regulator Bt4C1_10860 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Bt4C1_10885 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 Bt4C1_10900 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) Bt4C1_10915 ENOG4107RVG penicillin-binding protein Bt4C1_10925 ENOG4105E9Q Acyl-transferase Bt4C1_10930 ENOG4108UT2 hemolysin iii Bt4C1_10940 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Bt4C1_10950 ENOG4108RCR degv family Bt4C1_10960 ENOG4108KF3 Electron transport protein SCO1 SenC Bt4C1_10965 ENOG4107Y70 Heat shock protein Bt4C1_10970 ENOG4105CAQ asparagine synthetase Bt4C1_10985 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Bt4C1_10990 ENOG4108MES Periplasmic binding protein Bt4C1_10995 ENOG4105F0I Aminotransferase Bt4C1_11020 ENOG4105D8X mechanosensitive ion channel Bt4C1_11025 ENOG4105BZU Histidine kinase Bt4C1_11030 ENOG4105WH1 Two component transcriptional regulator luxr family Bt4C1_11035 ENOG4106KNT transcriptional regulator Bt4C1_11040 ENOG4107ZY0 Phenazine biosynthesis-like protein Bt4C1_11060 ENOG4105CMG Carbohydrate kinase Bt4C1_11065 ENOG4105C6Z Gluconate Bt4C1_11075 ENOG4108YV3 Protein of unknown function (DUF2711) Bt4C1_11105 ENOG4108IJ8 ABC transporter Bt4C1_11110 ENOG4105E90 ABC transporter Bt4C1_11145 ENOG4105C37 (CBS) domain Bt4C1_11170 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Bt4C1_11185 ENOG4107S4Y M20 DapE family protein YgeY Bt4C1_11190 ENOG4108TSC N-acetyltransferase Bt4C1_11195 ENOG4108JUB Transcriptional regulator Bt4C1_11200 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Bt4C1_11240 ENOG410841Q phosphoesterase PA-phosphatase related protein Bt4C1_11250 ENOG4105SZ6 Thioredoxin Bt4C1_11290 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Bt4C1_11345 ENOG4105BZ4 penicillin-binding protein Bt4C1_11355 ENOG4105CZM Major Facilitator Bt4C1_11360 ENOG4105W8X HesB YadR YfhF-family protein Bt4C1_11370 ENOG4105DXD 2-methylcitrate dehydratase Bt4C1_11375 ENOG4105CR4 methylisocitrate lyase Bt4C1_11380 ENOG4105C1G acyl-Coa dehydrogenase Bt4C1_11385 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Bt4C1_11395 ENOG4105N14 lysine exporter protein LysE YggA Bt4C1_11400 ENOG4105E39 Enoyl-CoA hydratase Bt4C1_11415 ENOG4107RFY SbcCD D subunit Bt4C1_11420 ENOG4105EYH Exonuclease Bt4C1_11440 ENOG4105FCD Major Facilitator Bt4C1_11445 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase Bt4C1_11450 ENOG4105E4F Isochorismate synthase Bt4C1_11455 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Bt4C1_11460 ENOG4105WQI isochorismatase Bt4C1_11465 ENOG4105CEY Amp-dependent synthetase and ligase Bt4C1_11470 ENOG4105WQT MbtH domain protein Bt4C1_11475 ENOG4105C0R drug resistance transporter emrb qaca subfamily Bt4C1_11490 ENOG4105K70 DNA-binding protein Bt4C1_11510 ENOG4105BZG amino acid carrier protein Bt4C1_11530 ENOG4105FE9 pseudouridine synthase Bt4C1_11535 ENOG4105C22 threonyL-tRNA synthetase Bt4C1_11540 ENOG4105C19 ABC transporter Bt4C1_11570 ENOG41081I9 integral membrane protein Bt4C1_11580 ENOG4108Y4K DNA-binding transcriptional activator Bt4C1_11595 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Bt4C1_11605 ENOG4105EYF MMPL domain protein Bt4C1_11630 ENOG4105WCN acetyltransferase Bt4C1_11655 ENOG4105C1Q protoporphyrinogen oxidase Bt4C1_11665 ENOG41068WN Bt4C1_11695 ENOG4107V2S Transcriptional regulator Bt4C1_11700 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Bt4C1_11710 ENOG4105DND Transcriptional regulator Bt4C1_11715 ENOG4108RPX mosc domain containing protein Bt4C1_11730 ENOG4105BZ1 (ABC) transporter Bt4C1_11735 ENOG4105BZ1 (ABC) transporter Bt4C1_11760 ENOG4108JCI Transcriptional regulator Bt4C1_11790 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) Bt4C1_11795 ENOG4108KPJ rna polymerase sigma factor Bt4C1_11820 ENOG4105F32 YngK protein Bt4C1_11845 ENOG4105RD7 BadF BadG BcrA BcrD Bt4C1_11850 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Bt4C1_11855 ENOG4107STF Involved in phosphonate degradation (By similarity) Bt4C1_11860 ENOG4105C7B Threonine dehydratase Bt4C1_11865 ENOG4108INS Transcriptional regulator Bt4C1_11955 ENOG4105C2M dna polymerase I Bt4C1_12040 ENOG4105KRN Transcriptional regulator, abrb family Bt4C1_12080 ENOG4108C33 Resolvase Bt4C1_12190 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Bt4C1_12255 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Bt4C1_12265 ENOG4105C1J atp-dependent rna helicase Bt4C1_12270 ENOG41088CC tellurite resistance protein tehB Bt4C1_12280 ENOG4108I0C methyltransferase Bt4C1_12320 ENOG4105CIN aminoacyl-histidine dipeptidase Bt4C1_12345 ENOG4105KRN Transcriptional regulator, abrb family Bt4C1_12355 ENOG4105EJ9 Membrane Bt4C1_12400 ENOG4105W8Z 4'-phosphopantetheinyl transferase Bt4C1_12410 ENOG4105CHR reductase Bt4C1_12470 ENOG4108W0I acetyltransferase Bt4C1_12475 ENOG4107QQG Dehydrogenase Bt4C1_12480 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Bt4C1_12485 ENOG4108IAJ Nad-dependent epimerase dehydratase Bt4C1_12490 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Bt4C1_12505 ENOG4105FJR Lmbe family Bt4C1_12515 ENOG4105IIU Aminopeptidase Bt4C1_12520 ENOG4108SC4 )-transporter Bt4C1_12565 ENOG4108IMY Transcriptional regulator Bt4C1_12575 ENOG4107VMI polysaccharide deacetylase Bt4C1_12605 ENOG4107RVG penicillin-binding protein Bt4C1_12620 ENOG4107RF6 penicillin-binding protein Bt4C1_12625 ENOG4107RF6 penicillin-binding protein Bt4C1_12635 ENOG4105DIN metallophosphoesterase Bt4C1_12645 ENOG4105CJ1 ABC, transporter Bt4C1_12655 ENOG4107Z3H Transcriptional regulator, TetR family Bt4C1_12670 ENOG4105C1G acyl-Coa dehydrogenase Bt4C1_12675 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Bt4C1_12680 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Bt4C1_12685 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Bt4C1_12690 ENOG4105E39 Enoyl-CoA hydratase Bt4C1_12695 ENOG4107QX3 carboxylase Bt4C1_12700 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Bt4C1_12725 ENOG4105DZ1 carboxypeptidase Bt4C1_12740 ENOG4105T9C HD domain Bt4C1_12755 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Bt4C1_12775 ENOG41075H3 AraC family transcriptional regulator Bt4C1_12805 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Bt4C1_12815 ENOG4105CHR reductase Bt4C1_12820 ENOG4105KVH Transcriptional regulator Bt4C1_12880 ENOG4105CPQ Dehydrogenase Bt4C1_12890 ENOG410900G Protein of unknown function (DUF421) Bt4C1_12900 ENOG4108V4B ThiJ pfpI Bt4C1_12910 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Bt4C1_12915 ENOG4105DK7 lysyl-tRNA synthetase Bt4C1_12940 ENOG4106NZI LysR family Transcriptional regulator Bt4C1_12945 ENOG4105CPC Aldo Keto reductase Bt4C1_12990 ENOG4105D6E homoserine dehydrogenase Bt4C1_13000 ENOG4105CPF Cell wall formation (By similarity) Bt4C1_13005 ENOG4105ETU transcriptional activator (TenA Bt4C1_13095 ENOG410667J hydrolase Bt4C1_13100 ENOG4105BZU Histidine kinase Bt4C1_13105 ENOG4107RF6 penicillin-binding protein Bt4C1_13130 ENOG4108JJB ABC transporter Bt4C1_13140 ENOG4108HGU Histidine kinase Bt4C1_13215 ENOG4105CB2 alcohol dehydrogenase Bt4C1_13220 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Bt4C1_13225 ENOG4105CJN penicillin-binding protein Bt4C1_13255 ENOG4107HNS degV-like protein Bt4C1_13305 ENOG4107Y9U Membrane Bt4C1_13325 ENOG4105EGD dinuclear metal center protein, YbgI family Bt4C1_13330 ENOG4105M6F mutator MutT protein Bt4C1_13350 ENOG4105FCD Major Facilitator Bt4C1_13365 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Bt4C1_13370 ENOG4108Z4K mutator MutT protein Bt4C1_13385 ENOG4108XI2 Domain of unknown function (DUF1963) Bt4C1_13405 ENOG4108NRW Phospholipase, patatin family Bt4C1_13410 ENOG4105KWG Pfam:DUF1696 Bt4C1_13435 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Bt4C1_13445 ENOG4105PKS Excinuclease abc c subunit domain protein Bt4C1_13480 ENOG41087PP glycosyltransferase MGT family Bt4C1_13485 ENOG41087PP glycosyltransferase MGT family Bt4C1_13500 ENOG4107VFR oxidoreductase Bt4C1_13525 ENOG4105U0R haloacid dehalogenase-like hydrolase Bt4C1_13530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_13535 ENOG4105BZU Histidine kinase Bt4C1_13555 ENOG4107WD8 ABC transporter, permease Bt4C1_13570 ENOG4105DY8 decarboxylase Bt4C1_13585 ENOG4108IUM Glycogen debranching enzyme Bt4C1_13595 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic Bt4C1_13610 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) Bt4C1_13615 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Bt4C1_13620 ENOG4105FDR Membrane Bt4C1_13625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_13675 ENOG4105MSI germination protein ypeb Bt4C1_13705 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) Bt4C1_13710 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) Bt4C1_13715 ENOG4107Z3H Transcriptional regulator, TetR family Bt4C1_13730 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family Bt4C1_13745 ENOG4105E98 transcriptional regulator DeoR family Bt4C1_13760 ENOG41062ES Transcriptional regulator Bt4C1_13780 ENOG4107QKR Dehydrogenase Bt4C1_13790 ENOG4107RUY (E1 component), alpha subunit Bt4C1_13800 ENOG4105E1F short-chain dehydrogenase reductase Bt4C1_13830 ENOG4107SQ8 Glycine betaine Bt4C1_13835 ENOG4108IJ7 Glycine betaine Bt4C1_13845 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Bt4C1_13860 ENOG4105E66 phosphoriboisomerase A Bt4C1_13865 ENOG41082BV acetyltransferase Bt4C1_13885 ENOG4108M1A Chitin-binding protein Bt4C1_13890 ENOG41087PP glycosyltransferase MGT family Bt4C1_13900 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Bt4C1_13915 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Bt4C1_13920 ENOG4105MSB protein, conserved in bacteria Bt4C1_13945 ENOG4108Z7F N-acetyltransferase Bt4C1_13970 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Bt4C1_13975 ENOG4105EEM helicase Bt4C1_13990 ENOG4105C9U ATP-dependent DNA helicase RecQ Bt4C1_14045 ENOG4108M1A Chitin-binding protein Bt4C1_14065 ENOG4105BZG amino acid carrier protein Bt4C1_14070 ENOG4105C26 Dehydrogenase Bt4C1_14075 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Bt4C1_14085 ENOG4105CTU Proline racemase Bt4C1_14090 ENOG41080HI glycine oxidase Bt4C1_14100 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein Bt4C1_14135 ENOG4105DCI Phosphohydrolase Bt4C1_14140 ENOG4107T5V SNARE associated Golgi Bt4C1_14150 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD Bt4C1_14165 ENOG4105DTQ mandelate racemase muconate lactonizing Bt4C1_14180 ENOG4107SET aldo keto reductase Bt4C1_14220 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) Bt4C1_14225 ENOG4105BZU Histidine kinase Bt4C1_14230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_14255 ENOG4105DPN Oligoendopeptidase f Bt4C1_14260 ENOG4105EPR degv family Bt4C1_14320 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) Bt4C1_14325 ENOG4106K7D Major facilitator family transporter Bt4C1_14345 ENOG4107BMA Transglycosylase associated protein Bt4C1_14360 ENOG41089UC methyltransferase, type 11 Bt4C1_14395 ENOG4105CHM Aminotransferase Bt4C1_14410 ENOG4108ZMI UPF0477 protein Bt4C1_14470 ENOG4105C02 permease Bt4C1_14485 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Bt4C1_14490 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein Bt4C1_14495 ENOG4105D7T ABC transporter Bt4C1_14520 ENOG4108AQF aminoglycoside N(3)-acetyltransferase Bt4C1_14555 ENOG4107VC0 DNA alkylation repair enzyme Bt4C1_14560 ENOG4105C6T cysteine synthase Bt4C1_14565 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase Bt4C1_14580 ENOG4107VMI polysaccharide deacetylase Bt4C1_14600 ENOG4108ZCF integral membrane protein Bt4C1_14605 ENOG4105E0M Sulfatase Bt4C1_14610 ENOG4105C5H ABC transporter Bt4C1_14615 ENOG4105EYF MMPL domain protein Bt4C1_14620 ENOG41082JN Transcriptional regulator Bt4C1_14645 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Bt4C1_14650 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Bt4C1_14685 ENOG41069ER domain protein Bt4C1_14715 ENOG4105D4B ABC, transporter Bt4C1_14725 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane Bt4C1_14735 ENOG4105DKT Transcriptional regulator Bt4C1_14740 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) Bt4C1_14750 ENOG41061GT Aldolase Bt4C1_14765 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) Bt4C1_14795 ENOG4105II7 pyrroline-5-carboxylate reductase Bt4C1_14805 ENOG4107258 Transcriptional regulator Bt4C1_14820 ENOG4105E0Y RtcB Protein Bt4C1_14825 ENOG4105ECK Fatty Acid Desaturase Bt4C1_14835 ENOG4107RBI VanW family Bt4C1_14840 ENOG4105G6Z alkaline phosphatase Bt4C1_14850 ENOG4105VMP Transcriptional regulator Bt4C1_14870 ENOG4105KNA -acetyltransferase Bt4C1_14895 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Bt4C1_14920 ENOG4105C8Y Acetylornithine aminotransferase Bt4C1_14950 ENOG41090AA Bt4C1_14955 ENOG4106BHF Bt4C1_14975 ENOG4108IBT Inherit from COG: transposase Bt4C1_14995 ENOG4108TVJ Nitroreductase Bt4C1_15000 ENOG4105FS7 Transcriptional regulator Bt4C1_15015 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Bt4C1_15020 ENOG4105WEC Molybdate metabolism regulator Bt4C1_15025 ENOG4105CMR udp-glucose 4-epimerase Bt4C1_15030 ENOG4105C19 ABC transporter Bt4C1_15055 ENOG4108XET gCN5-related N-acetyltransferase Bt4C1_15065 ENOG4105E09 nadh pyrophosphatase Bt4C1_15070 ENOG4108PCN EamA-like transporter family Bt4C1_15115 ENOG410635A Membrane Bt4C1_15125 ENOG4108IQI permease Bt4C1_15170 ENOG4108VJ1 Transcriptional regulator (CarD family Bt4C1_15180 ENOG4105BZU Histidine kinase Bt4C1_15205 ENOG4107RF6 penicillin-binding protein Bt4C1_15210 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Bt4C1_15240 ENOG4105P4J Allophanate hydrolase, subunit 1 Bt4C1_15245 ENOG4107258 Transcriptional regulator Bt4C1_15255 ENOG4106N3A copper homeostasis protein cutc Bt4C1_15260 ENOG4108ZHR arsR family transcriptional regulator Bt4C1_15270 ENOG4105FDT acyl-CoA dehydrogenase Bt4C1_15285 ENOG4105DWD nucleoside recognition domain protein Bt4C1_15325 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Bt4C1_15350 ENOG4105E2A Dehydrogenase Bt4C1_15365 ENOG4105HDK L-asparaginase Bt4C1_15370 ENOG4108IMY Transcriptional regulator Bt4C1_15380 ENOG4108B31 Spore germination protein Bt4C1_15390 ENOG4105BZU Histidine kinase Bt4C1_15415 ENOG41075H3 AraC family transcriptional regulator Bt4C1_15420 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Bt4C1_15425 ENOG4105CUB amino acid Bt4C1_15430 ENOG4105II7 pyrroline-5-carboxylate reductase Bt4C1_15435 ENOG4108NHD germination protein Bt4C1_15440 ENOG4108Q8B Spore germination protein Bt4C1_15475 ENOG4106A3M Cytochrome p-450 Bt4C1_15500 ENOG4105CHJ isochorismatase hydrolase Bt4C1_15525 ENOG41090MY MarR family Transcriptional regulator Bt4C1_15550 ENOG4105F6J Alpha beta hydrolase fold Bt4C1_15565 ENOG4108606 TspO/MBR family Bt4C1_15570 ENOG4105CVP deoxyribo-dipyrimidine photolyase Bt4C1_15585 ENOG4108TWJ NADH dehydrogenase subunit 5 Bt4C1_15590 ENOG4105GPN Uncharacterized conserved protein (DUF2294) Bt4C1_15595 ENOG4107VMI polysaccharide deacetylase Bt4C1_15605 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Bt4C1_15610 ENOG4105DSE periplasmic solute binding protein Bt4C1_15615 ENOG4105CC5 ABC transporter Bt4C1_15620 ENOG4105DIK (ABC) transporter Bt4C1_15640 ENOG4105D6J arsenicaL-resistance protein Bt4C1_15645 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase Bt4C1_15650 ENOG41085FC arsR family transcriptional regulator Bt4C1_15695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_15700 ENOG41062D9 Histidine kinase Bt4C1_15735 ENOG4105DNP FAD linked oxidase domain protein Bt4C1_15745 ENOG4105C19 ABC transporter Bt4C1_15775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) Bt4C1_15780 ENOG4105C0R drug resistance transporter emrb qaca subfamily Bt4C1_15795 ENOG4105K6H D-cysteine desulfhydrase Bt4C1_15810 ENOG4105JQZ Methyltransferase Bt4C1_15830 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) Bt4C1_15835 ENOG4105BZU Histidine kinase Bt4C1_15850 ENOG4108U05 Transcriptional regulator Bt4C1_15855 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 Bt4C1_15865 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) Bt4C1_15880 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A Bt4C1_15900 ENOG4108JQ1 Dehydrogenase Bt4C1_15905 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Bt4C1_15920 ENOG41082W1 Cupin 2, conserved barrel domain protein Bt4C1_15925 ENOG410874W AraC family transcriptional regulator Bt4C1_15940 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Bt4C1_15950 ENOG4108IG5 Transcriptional regulator Bt4C1_16065 ENOG4107EV6 Inherit from COG: YD repeat protein Bt4C1_16090 ENOG4108VXD carboxy-peptidase Bt4C1_16095 ENOG4105PNM synthesis protein Bt4C1_16105 ENOG4108ISG Major Facilitator Bt4C1_16120 ENOG4107MII Sugar-specific transcriptional regulator TrmB Bt4C1_16125 ENOG4105CZM Major Facilitator Bt4C1_16135 ENOG4105CRW Short chain fatty acid transporter Bt4C1_16145 ENOG4105DYS nad(p)h dehydrogenase (quinone) Bt4C1_16205 ENOG4108K8S endonuclease I Bt4C1_16215 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) Bt4C1_16220 ENOG4108Z66 YbaK ebsC protein Bt4C1_16240 ENOG4105KVH Transcriptional regulator Bt4C1_16245 ENOG4108RCM Nitroreductase Bt4C1_16275 ENOG4108PSK reductase Bt4C1_16340 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase Bt4C1_16345 ENOG4105DKQ ROK family Bt4C1_16350 ENOG4106UW1 Major Facilitator superfamily Bt4C1_16355 ENOG4108UW5 maltose o-acetyltransferase Bt4C1_16360 ENOG4105C31 Tryptophanyl-tRNA synthetase Bt4C1_16365 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Bt4C1_16405 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Bt4C1_16415 ENOG4105EV4 Multidrug resistance protein mdtH Bt4C1_16445 ENOG4105C37 (CBS) domain Bt4C1_16470 ENOG4105DDN Pentapeptide repeat-containing protein Bt4C1_16475 ENOG4105XDF Protein of unknown function (DUF1272) Bt4C1_16480 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) Bt4C1_16485 ENOG4105CMG Carbohydrate kinase Bt4C1_16490 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Bt4C1_16500 ENOG4105CV1 Transketolase (EC 2.2.1.1) Bt4C1_16505 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase Bt4C1_16520 ENOG4105C44 Serine transporter Bt4C1_16550 ENOG4105KVH Transcriptional regulator Bt4C1_16555 ENOG4108TZY GntR Family Transcriptional Regulator Bt4C1_16560 ENOG4105D9R oxidoreductase Bt4C1_16605 ENOG4105JAB phenazine biosynthesis protein, phzf family Bt4C1_16620 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein Bt4C1_16625 ENOG4105KVH Transcriptional regulator Bt4C1_16630 ENOG4107SCK Monooxygenase Bt4C1_16645 ENOG4108ZJ4 polysaccharide deacetylase Bt4C1_16700 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Bt4C1_16730 ENOG4105H3G oxidoreductase Bt4C1_16765 ENOG4105CIS alcohol dehydrogenase Bt4C1_16800 ENOG4108TN2 lmbE family Bt4C1_16810 ENOG4107R3E Citrate transporter Bt4C1_16820 ENOG4105WCN acetyltransferase Bt4C1_16825 ENOG4105NX3 Membrane Bt4C1_16845 ENOG4107CUJ Protein of unknown function (DUF2690) Bt4C1_16855 ENOG4107V2S Transcriptional regulator Bt4C1_16875 ENOG4105C98 muts2 protein Bt4C1_16885 ENOG4105E5K Alpha-amylase Bt4C1_16890 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase Bt4C1_16895 ENOG4105DPN Oligoendopeptidase f Bt4C1_16900 ENOG4105DWY Agmatine deiminase Bt4C1_16925 ENOG4108A04 Beta-lactamase Bt4C1_16935 ENOG4105E5T Major Facilitator Superfamily Bt4C1_16950 ENOG4107VXM glycerophosphoryl diester phosphodiesterase Bt4C1_16960 ENOG41082BM Transcriptional regulator, arsr family Bt4C1_16965 ENOG4105CIS alcohol dehydrogenase Bt4C1_16985 ENOG4105C09 Bile acid Bt4C1_16990 ENOG4105CQB FAD linked oxidase domain protein Bt4C1_17010 ENOG4105CEP NADH dehydrogenase Bt4C1_17035 ENOG4105D2T synthase Bt4C1_17050 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Bt4C1_17055 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Bt4C1_17060 ENOG4105C1B dTDP-glucose 4-6-dehydratase Bt4C1_17065 ENOG4105C5E polysaccharide biosynthesis protein Bt4C1_17090 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C Bt4C1_17095 ENOG4108M1A Chitin-binding protein Bt4C1_17105 ENOG4105E1K spore germination protein Bt4C1_17125 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase Bt4C1_17140 ENOG4105FAW cDP-glucose 4,6-dehydratase Bt4C1_17190 ENOG4105BZU Histidine kinase Bt4C1_17200 ENOG4105C5H ABC transporter Bt4C1_17205 ENOG41067SE Tetr family transcriptional regulator Bt4C1_17210 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity Bt4C1_17220 ENOG4108VXD carboxy-peptidase Bt4C1_17225 ENOG4107DUR UPF0457 protein Bt4C1_17245 ENOG4105BZU Histidine kinase Bt4C1_17255 ENOG4105KT7 mgtC SapB transporter Bt4C1_17265 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase Bt4C1_17270 ENOG41073R8 VanW family Bt4C1_17280 ENOG4108R1P Bt4C1_17295 ENOG4105VEQ Cold shock protein Bt4C1_17315 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Bt4C1_17335 ENOG410904N short-chain dehydrogenase reductase Bt4C1_17345 ENOG4106IQC argininosuccinate lyase Bt4C1_17360 ENOG4108IA2 Sodium pantothenate symporter Bt4C1_17370 ENOG4105C26 Dehydrogenase Bt4C1_17375 ENOG4105CHR reductase Bt4C1_17385 ENOG4105EWU Squalene--hopene cyclase Bt4C1_17395 ENOG4105FR1 rard protein Bt4C1_17400 ENOG410696E Membrane Bt4C1_17415 ENOG4105D1F ATP-binding protein Bt4C1_17425 ENOG4108ZAF Molybdopterin Bt4C1_17430 ENOG4105CVM Molybdenum cofactor synthesis domain protein Bt4C1_17435 ENOG4105D06 uba thif-type nad fad binding protein Bt4C1_17440 ENOG4105TMB Formate nitrite transporter Bt4C1_17450 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Bt4C1_17455 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) Bt4C1_17465 ENOG4108JB9 formate dehydrogenase Bt4C1_17470 ENOG4105E1K spore germination protein Bt4C1_17535 ENOG4107QJT sodium dicarboxylate symporter Bt4C1_17540 ENOG4108KGH TRANSCRIPTIONal Bt4C1_17550 ENOG4105EMN RNA polymerase sigma factor Bt4C1_17560 ENOG4105CIG ABC transporter Bt4C1_17580 ENOG4105D9R oxidoreductase Bt4C1_17590 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Bt4C1_17595 ENOG4105K4P CoA-binding domain protein Bt4C1_17600 ENOG4105C0H protease Bt4C1_17605 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_17615 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase Bt4C1_17620 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Bt4C1_17625 ENOG4105W8X HesB YadR YfhF-family protein Bt4C1_17650 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Bt4C1_17655 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Bt4C1_17665 ENOG4105BZ1 (ABC) transporter Bt4C1_17670 ENOG4108I0Z Aconitate hydratase Bt4C1_17700 ENOG4105E5W Transporter Bt4C1_17710 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Bt4C1_17730 ENOG4107F3J Amp-dependent synthetase and ligase Bt4C1_17735 ENOG4107ZYJ bioY protein Bt4C1_17740 ENOG4105CEY Amp-dependent synthetase and ligase Bt4C1_17745 ENOG4108IMY Transcriptional regulator Bt4C1_17780 ENOG4107AYK membrAne Bt4C1_17790 ENOG4105BZU Histidine kinase Bt4C1_17795 ENOG4105FBA Phospholipase Carboxylesterase Bt4C1_17800 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase Bt4C1_17805 ENOG4105CK7 Sodium proline symporter Bt4C1_17815 ENOG4105CBC glutamate synthase Bt4C1_17820 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Bt4C1_17825 ENOG4108VJ1 Transcriptional regulator (CarD family Bt4C1_17830 ENOG4108903 Formimidoylglutamase Bt4C1_17885 ENOG4107QIV Cytochrome c biogenesis protein Bt4C1_17895 ENOG4105CH2 amidohydrolase Bt4C1_17905 ENOG4105CJ1 ABC, transporter Bt4C1_17925 ENOG4107RSM transcriptional regulator Bt4C1_17930 ENOG4105VAW lrga family Bt4C1_17935 ENOG41067MG lrgb family Bt4C1_17975 ENOG4105BZ1 (ABC) transporter Bt4C1_17980 ENOG4105BZ1 (ABC) transporter Bt4C1_18015 ENOG4108HW3 (ABC) transporter Bt4C1_18020 ENOG4105CGH 5'-nucleotidase Bt4C1_18030 ENOG4108SVB resolvase Bt4C1_18050 ENOG4105K7K Transcriptional regulator Bt4C1_18060 ENOG4105E4C Lytic transglycosylase catalytic Bt4C1_18065 ENOG41065S2 pneumococcal vaccine antigen Bt4C1_18100 ENOG4105C5F glutamine synthetase Bt4C1_18105 ENOG4105KV4 Transcriptional regulator Bt4C1_18110 ENOG4105CXI aluminum resistance protein Bt4C1_18115 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Bt4C1_18120 ENOG4105EN6 Membrane Bt4C1_18130 ENOG4106F1P AAA ATPase, central domain protein Bt4C1_18160 ENOG41069ER domain protein Bt4C1_18165 ENOG4105DM4 PTS System Bt4C1_18170 ENOG4105DE4 1-phosphofructokinase Bt4C1_18175 ENOG4105E98 transcriptional regulator DeoR family Bt4C1_18180 ENOG4107QW4 alcohol dehydrogenase Bt4C1_18185 ENOG4108SJC Membrane Bt4C1_18200 ENOG4105C85 amino acid Bt4C1_18225 ENOG4105K70 DNA-binding protein Bt4C1_18235 ENOG4105C59 p-type ATPase Bt4C1_18240 ENOG410681U heavy metal transport detoxification protein Bt4C1_18245 ENOG4105VPX protein, conserved in bacteria Bt4C1_18265 ENOG4105NIV Esterase Bt4C1_18270 ENOG4105E0A ABC, transporter Bt4C1_18290 ENOG4105CGK Exodeoxyribonuclease III Bt4C1_18300 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Bt4C1_18305 ENOG4105D03 DNA-3-methyladenine glycosylase II Bt4C1_18335 ENOG4105BZU Histidine kinase Bt4C1_18370 ENOG41067MG lrgb family Bt4C1_18395 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_18400 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C Bt4C1_18410 ENOG4105F0V Cell wall hydrolase Bt4C1_18420 ENOG4105E0M Sulfatase Bt4C1_18425 ENOG410890F Dynamin family Bt4C1_18460 ENOG4105DQU oxidoreductase, subunit beta Bt4C1_18465 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Bt4C1_18470 ENOG4108IGT Dipeptidase Bt4C1_18475 ENOG4105MCT stage V sporulation protein S Bt4C1_18480 ENOG4105D48 metallophosphoesterase Bt4C1_18505 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Bt4C1_18520 ENOG4105XZV Protein of unknown function (DUF3243) Bt4C1_18525 ENOG4108RKS Short-chain dehydrogenase reductase Sdr Bt4C1_18545 ENOG4105UIB (ABC) transporter Bt4C1_18550 ENOG4108JQ9 ABC transporter Bt4C1_18555 ENOG4105DIH basic membrane Bt4C1_18560 ENOG4105FDP GntR family transcriptional regulator Bt4C1_18565 ENOG4105CNU cell division protein FtsK Bt4C1_18575 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit Bt4C1_18585 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Bt4C1_18595 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Bt4C1_18600 ENOG4108S0H Dipicolinic acid synthetase, b subunit Bt4C1_18605 ENOG4105E35 Dipicolinate synthase subunit A Bt4C1_18615 ENOG4105C1V Peptidase, M16 Bt4C1_18635 ENOG4105DTN riboflavin biosynthesis protein ribF Bt4C1_18650 ENOG4105W7A Protein of unknown function (DUF503) Bt4C1_18660 ENOG4105VHM ribosomal protein Bt4C1_18665 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination Bt4C1_18670 ENOG4105CHV Transcription elongation factor NusA Bt4C1_18680 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Bt4C1_18690 ENOG4105DZP Membrane-associated zinc metalloprotease Bt4C1_18695 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Bt4C1_18700 ENOG4105KNE Phosphatidate cytidylyltransferase Bt4C1_18705 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Bt4C1_18715 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Bt4C1_18745 ENOG4108HE4 integrase family Bt4C1_18755 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Bt4C1_18760 ENOG4105C79 DNA protecting protein DprA Bt4C1_18765 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Bt4C1_18780 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) Bt4C1_18805 ENOG4105VB6 UPF0109 protein Bt4C1_18825 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Bt4C1_18830 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Bt4C1_18845 ENOG4105CHR reductase Bt4C1_18850 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Bt4C1_18865 ENOG4105CB5 ATP-dependent DNA helicase recG Bt4C1_18870 ENOG4105DP4 dak2 domain fusion protein ylov Bt4C1_18875 ENOG4108ZAA Alkaline-shock protein Bt4C1_18890 ENOG4105FJ0 thiamine Bt4C1_18895 ENOG4105DJV ribulose-phosphate 3-epimerase Bt4C1_18900 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) Bt4C1_18905 ENOG4105D9P serine threonine protein kinase Bt4C1_18910 ENOG4108ZF3 Phosphatase Bt4C1_18920 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Bt4C1_18935 ENOG4105C25 Primosomal protein n' Bt4C1_18940 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Bt4C1_18960 ENOG4105DSJ YicC domain protein Bt4C1_18970 ENOG4105F23 Fibronectin-binding protein Bt4C1_19060 ENOG4105C34 Pseudouridine synthase Bt4C1_19075 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Bt4C1_19085 ENOG4105DBK s4 domain protein Bt4C1_19090 ENOG41067XK integral membrane protein Bt4C1_19100 ENOG4105DFA alanine racemase domain protein Bt4C1_19105 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Bt4C1_19110 ENOG4105WR5 sporulation protein, YlmC YmxH family Bt4C1_19120 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Bt4C1_19130 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Bt4C1_19135 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Bt4C1_19145 ENOG4105D4A Cell wall formation (By similarity) Bt4C1_19150 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Bt4C1_19155 ENOG4105CNI cell division protein FtsW Bt4C1_19170 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Bt4C1_19175 ENOG4105CJN penicillin-binding protein Bt4C1_19180 ENOG4105CJN penicillin-binding protein Bt4C1_19220 ENOG4105KNH Nucleic acid-binding protein Bt4C1_19230 ENOG41063PX domain protein Bt4C1_19235 ENOG4105D78 K07001 NTE family protein Bt4C1_19240 ENOG4105H20 Sporulation integral membrane protein YlbJ Bt4C1_19250 ENOG4106H78 methyltransferase Bt4C1_19270 ENOG4107TB6 phosphoglycerate mutase Bt4C1_19285 ENOG4106UY4 Inherit from COG: Scp-like extracellular Bt4C1_19335 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Bt4C1_19340 ENOG4105CNI cell division protein FtsW Bt4C1_19355 ENOG4108IAB Phoh family Bt4C1_19375 ENOG4105QA2 Bt4C1_19380 ENOG4105CI3 gtp-binding protein typa Bt4C1_19390 ENOG4105ECY inositol monophosphatase Bt4C1_19410 ENOG4105CXN decarboxylase Bt4C1_19460 ENOG4105CPP Dehydrogenase, E1 component Bt4C1_19475 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Bt4C1_19480 ENOG4108X4Q Hydrolase Bt4C1_19490 ENOG4105CN5 Metallo-Beta-Lactamase Bt4C1_19495 ENOG4107ZYR domain protein Bt4C1_19530 ENOG4108XRC Protein of unknown function (DUF458) Bt4C1_19540 ENOG4107IN1 Protein of unknown function (DUF1797) Bt4C1_19555 ENOG4105EPM Diguanylate phosphodiesterase Bt4C1_19560 ENOG4105K6S Short-chain dehydrogenase reductase Sdr Bt4C1_19575 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Bt4C1_19585 ENOG4105UIN Bt4C1_19640 ENOG4108HGU Histidine kinase Bt4C1_19650 ENOG4105CHM Aminotransferase Bt4C1_19655 ENOG4105FKQ transcriptional regulator Bt4C1_19660 ENOG4105EG2 ABC transporter, permease Bt4C1_19670 ENOG4107FKK extracellular solute-binding protein family 1 Bt4C1_19680 ENOG4105CG3 alpha amylase, catalytic region Bt4C1_19725 ENOG4105CHU acetyl-coa acetyltransferase Bt4C1_19755 ENOG4105K7K Transcriptional regulator Bt4C1_19760 ENOG4105DTD Dehydrogenase Bt4C1_19780 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Bt4C1_19805 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) Bt4C1_19820 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Bt4C1_19830 ENOG4105BZU Histidine kinase Bt4C1_19850 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Bt4C1_19865 ENOG4105CID antiterminator Bt4C1_19875 ENOG4105FDP GntR family transcriptional regulator Bt4C1_19885 ENOG4105CE4 GlcNAc 6-P deacetylase Bt4C1_19920 ENOG4107ZE5 PPIases accelerate the folding of proteins Bt4C1_19925 ENOG4105PTM secreted protein Bt4C1_19930 ENOG4105J7I hydrolase Bt4C1_19940 ENOG4105G6R Stage v sporulation protein ae Bt4C1_19950 ENOG4105CZ3 stage V sporulation protein ad Bt4C1_19955 ENOG41090VF Stage v sporulation protein ac Bt4C1_19980 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Bt4C1_19990 ENOG41082AN stage II sporulation protein Bt4C1_19995 ENOG4105DZ1 carboxypeptidase Bt4C1_20000 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_20005 ENOG4105DVE abc transporter atp-binding protein Bt4C1_20040 ENOG4105D7N magnesium and cobalt transport protein CorA Bt4C1_20065 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Bt4C1_20075 ENOG4105I3K Ferric uptake regulator, Fur family Bt4C1_20080 ENOG4105MZ9 stage II sporulation protein m Bt4C1_20100 ENOG4105CPC Aldo Keto reductase Bt4C1_20110 ENOG4105RHY Pfam:UPF0157 Bt4C1_20130 ENOG4107SKW Inherit from COG: Alpha beta hydrolase Bt4C1_20140 ENOG4105ETE Transcriptional regulator (LacI family Bt4C1_20145 ENOG4108YM7 Gcn5-related n-acetyltransferase Bt4C1_20165 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Bt4C1_20170 ENOG4108R6K riboflavin synthase, subunit alpha Bt4C1_20195 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Bt4C1_20200 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Bt4C1_20215 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Bt4C1_20225 ENOG4105DFD Na H antiporter Bt4C1_20230 ENOG4105CGH 5'-nucleotidase Bt4C1_20255 ENOG4105DBV ornithine carbamoyltransferase Bt4C1_20270 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Bt4C1_20285 ENOG4108IXY short-chain dehydrogenase reductase Bt4C1_20290 ENOG41069FQ Metallo-beta-lactamase superfamily Bt4C1_20295 ENOG4105II7 pyrroline-5-carboxylate reductase Bt4C1_20300 ENOG4105EJQ L-serine dehydratase Bt4C1_20325 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic Bt4C1_20340 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) Bt4C1_20345 ENOG4105D9U N-acetyltransferase Bt4C1_20355 ENOG4108VZI ErfK ybiS ycfS ynhG family protein Bt4C1_20360 ENOG4108QEG Membrane Bt4C1_20365 ENOG4105CDA abc transporter atp-binding protein Bt4C1_20370 ENOG4105E5Q amino acid AbC transporter Bt4C1_20375 ENOG4108HW3 (ABC) transporter Bt4C1_20385 ENOG4105G7B Protein of unknown function (DUF2992) Bt4C1_20395 ENOG4108QY0 Membrane Bt4C1_20405 ENOG4105C7S Dehydrogenase Bt4C1_20410 ENOG4105CPP Dehydrogenase, E1 component Bt4C1_20430 ENOG4107RDP Dehydrogenase Bt4C1_20445 ENOG4108JUB Transcriptional regulator Bt4C1_20455 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Bt4C1_20470 ENOG4107QQR Sporulation Bt4C1_20475 ENOG4105S1Z Stage IV sporulation protein B Bt4C1_20480 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Bt4C1_20485 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Bt4C1_20490 ENOG4105DX0 Hemolysin A Bt4C1_20500 ENOG4105CTB Polyprenyl synthetase Bt4C1_20525 ENOG4108ZSR alkaline shock protein Bt4C1_20530 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Bt4C1_20550 ENOG410644B Stage III sporulation protein af Bt4C1_20560 ENOG4105KQ4 Stage iii sporulation protein ad Bt4C1_20565 ENOG4108CQH stage III sporulation protein AC Bt4C1_20570 ENOG4105KR5 Stage iii sporulation protein Bt4C1_20575 ENOG4105CD2 stage iii sporulation protein aa Bt4C1_20600 ENOG4105DC7 peptidase M24 Bt4C1_20615 ENOG4105CBJ Metal-dependent enzyme Bt4C1_20625 ENOG4107YBY Hydrolase Bt4C1_20655 ENOG41082GG biotin lipoate A B protein ligase Bt4C1_20660 ENOG4105WZW rhodanese family Bt4C1_20685 ENOG41080TC multidrug resistance protein Bt4C1_20715 ENOG4105CJ1 ABC, transporter Bt4C1_20720 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_20750 ENOG4105C0D helicase Bt4C1_20780 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Bt4C1_20835 ENOG4107R6U sodium dicarboxylate symporter Bt4C1_20870 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Bt4C1_20875 ENOG4105C3R Methionine synthase Bt4C1_20885 ENOG4105C28 cystathionine Bt4C1_20890 ENOG4105C28 cystathionine Bt4C1_20910 ENOG4105C5X domain protein Bt4C1_20915 ENOG4105DKQ ROK family Bt4C1_20925 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase Bt4C1_20940 ENOG4108UTW Plays a role in the regulation of phosphate uptake Bt4C1_20945 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_20950 ENOG4105C8U phosphate abc transporter Bt4C1_20955 ENOG4105C8U phosphate abc transporter Bt4C1_20965 ENOG4107RF6 penicillin-binding protein Bt4C1_20975 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Bt4C1_21000 ENOG4105N80 Ferric uptake regulator, Fur family Bt4C1_21010 ENOG4105FDK ABC transporter Bt4C1_21015 ENOG4108JYZ YitT family Bt4C1_21020 ENOG41069ZM Protein of unknown function (DUF2624) Bt4C1_21045 ENOG4105EGD dinuclear metal center protein, YbgI family Bt4C1_21060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Bt4C1_21065 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Bt4C1_21090 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Bt4C1_21095 ENOG4105KG3 cytidine deaminase Bt4C1_21100 ENOG4107YR5 Diacylglycerol kinase Bt4C1_21110 ENOG4105CTJ Metal Dependent Phosphohydrolase Bt4C1_21115 ENOG4105C9A Phoh family Bt4C1_21125 ENOG41068P3 sporulation protein YqfC Bt4C1_21130 ENOG4105KTH gatB Yqey Bt4C1_21140 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Bt4C1_21145 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) Bt4C1_21175 ENOG4105CSA Coproporphyrinogen iii oxidase Bt4C1_21180 ENOG4105KVH Transcriptional regulator Bt4C1_21205 ENOG4105TQK DNA polymerase iii, delta' subunit Bt4C1_21215 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 Bt4C1_21220 ENOG4108UK2 deaminase Bt4C1_21225 ENOG4105KQC Competence protein Bt4C1_21235 ENOG4105DXX methyltransferase Bt4C1_21245 ENOG4108WF2 Metal Dependent Phosphohydrolase Bt4C1_21255 ENOG410812S Rna-binding protein Bt4C1_21265 ENOG4105CQW ribosome biogenesis GTPase YqeH Bt4C1_21270 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase Bt4C1_21285 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Bt4C1_21305 ENOG4108TVJ Nitroreductase Bt4C1_21320 ENOG4105G6Z alkaline phosphatase Bt4C1_21325 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Bt4C1_21330 ENOG4108MUZ hydrolase Bt4C1_21365 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin Bt4C1_21370 ENOG4105MIR Phenylalanine 4-monooxygenase Bt4C1_21380 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase Bt4C1_21420 ENOG4105S6R Iron-hydroxamate transporter permease subunit Bt4C1_21425 ENOG4108HUF Transporter Bt4C1_21435 ENOG4108EKI Dehydrogenase Bt4C1_21440 ENOG4105C28 cystathionine Bt4C1_21470 ENOG4107XRG penicillin-binding protein Bt4C1_21480 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Bt4C1_21490 ENOG4105CFP Peptidase U32 Bt4C1_21495 ENOG4105XYU peptidase (U32 family) Bt4C1_21500 ENOG4108VQJ O-methyltransferase Bt4C1_21505 ENOG4105HHA aminodeoxychorismate lyase Bt4C1_21525 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Bt4C1_21535 ENOG4105C02 permease Bt4C1_21550 ENOG41060CR Bt4C1_21555 ENOG4105C7H Helicase, RecD TraA family Bt4C1_21565 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Bt4C1_21570 ENOG4105C3J Cysteine desulfurase Bt4C1_21580 ENOG4105D1H recombination factor protein RarA Bt4C1_21585 ENOG4108VCI transcription factor, rsfa family Bt4C1_21590 ENOG4105CUZ uba thif-type nad fad binding protein Bt4C1_21600 ENOG4105CUT histidyl-tRNA synthetase Bt4C1_21620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Bt4C1_21630 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Bt4C1_21635 ENOG41076HS cation diffusion facilitator family transporter Bt4C1_21640 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Bt4C1_21650 ENOG4105CKP Polysaccharide Biosynthesis Protein Bt4C1_21655 ENOG4108QG2 Membrane Bt4C1_21665 ENOG4105VIE preprotein translocase, subunit YajC Bt4C1_21680 ENOG41061AI Protein of unknown function (DUF2905) Bt4C1_21695 ENOG4108HUF Transporter Bt4C1_21725 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Bt4C1_21730 ENOG4108IYU L-aspartate oxidase Bt4C1_21745 ENOG4108RPX mosc domain containing protein Bt4C1_21755 ENOG4105CQC Prephenate dehydratase Bt4C1_21775 ENOG4105EWM Histidine kinase Bt4C1_21800 ENOG4105X36 (ribosomal) protein Bt4C1_21810 ENOG4105C03 ribonuclease Bt4C1_21825 ENOG4107QMS site-determining protein Bt4C1_21840 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) Bt4C1_21845 ENOG4105DFF Rod shape-determining protein mreb Bt4C1_21865 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Bt4C1_21870 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Bt4C1_21880 ENOG41068KH stage VI sporulation protein D Bt4C1_21890 ENOG4105D52 delta-aminolevulinic acid dehydratase Bt4C1_21915 ENOG4105K56 Transcriptional regulator Bt4C1_21935 ENOG4108IUQ atp-dependent protease Bt4C1_21955 ENOG4108QCI YvbH-like oligomerisation region Bt4C1_21960 ENOG4105DQ6 Transposase Bt4C1_22050 ENOG4105M59 Phosphodiesterase, mj0936 family Bt4C1_22065 ENOG4108XJQ germination protein Bt4C1_22075 ENOG4108PCX Major Facilitator Bt4C1_22085 ENOG4105KBX Transcriptional regulator, TetR family Bt4C1_22095 ENOG4105PFC Transcriptional regulator Bt4C1_22105 ENOG4105DZC cytosine deaminase Bt4C1_22110 ENOG41067S9 phage shock protein C, PspC Bt4C1_22115 ENOG4108JCI Transcriptional regulator Bt4C1_22125 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Bt4C1_22130 ENOG4108Z40 Transcriptional regulator Bt4C1_22135 ENOG4105RHA ABC transporter, permease Bt4C1_22140 ENOG4108IUX (ABC) transporter Bt4C1_22145 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family Bt4C1_22150 ENOG4105ER2 Ompa motb domain protein Bt4C1_22155 ENOG4105E14 MotA TolQ exbB proton channel Bt4C1_22160 ENOG4108VXD carboxy-peptidase Bt4C1_22170 ENOG4105E33 succinate dehydrogenase Bt4C1_22180 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit Bt4C1_22195 ENOG4105K63 Thioredoxin Bt4C1_22200 ENOG4105C10 Electron transfer flavoprotein Bt4C1_22205 ENOG4105BZJ Electron transfer flavoprotein Bt4C1_22210 ENOG41060WC Enoyl-CoA hydratase Bt4C1_22215 ENOG4107Z3H Transcriptional regulator, TetR family Bt4C1_22220 ENOG4105CEY Amp-dependent synthetase and ligase Bt4C1_22230 ENOG4105J76 Periplasmic binding protein Bt4C1_22235 ENOG4105S6R Iron-hydroxamate transporter permease subunit Bt4C1_22270 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Bt4C1_22285 ENOG4105DR4 Methyltransferase Bt4C1_22295 ENOG4105KFN sortase, SrtB family Bt4C1_22300 ENOG4105E0A ABC, transporter Bt4C1_22315 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) Bt4C1_22325 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) Bt4C1_22335 ENOG4105FE9 pseudouridine synthase Bt4C1_22345 ENOG4105DCG PHP domain protein Bt4C1_22360 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Bt4C1_22375 ENOG4105C5S asparaginyl-tRNA synthetase Bt4C1_22380 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Bt4C1_22390 ENOG4108RWN rrna methyltransferase Bt4C1_22415 ENOG4105C0R drug resistance transporter emrb qaca subfamily Bt4C1_22420 ENOG4105CW7 secretion protein, HlyD family Bt4C1_22425 ENOG4108JGH Tetr family transcriptional regulator Bt4C1_22430 ENOG4105CN9 Peptidase m42 family protein Bt4C1_22450 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Bt4C1_22455 ENOG4105C22 threonyL-tRNA synthetase Bt4C1_22460 ENOG4108TDW sporulation protein YtxC Bt4C1_22485 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Bt4C1_22490 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Bt4C1_22495 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Bt4C1_22505 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Bt4C1_22510 ENOG4105C2M dna polymerase I Bt4C1_22515 ENOG4105BZU Histidine kinase Bt4C1_22520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Bt4C1_22540 ENOG4108HMX isocitrate dehydrogenase (NADP) Bt4C1_22545 ENOG4105BZN citrate synthase Bt4C1_22555 ENOG4108REF Sporulation integral membrane protein ytvi Bt4C1_22560 ENOG4105FS0 cytoplasmic membrane protein Bt4C1_22585 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family Bt4C1_22595 ENOG4105C0B DNA polymerase III (alpha subunit) Bt4C1_22600 ENOG4105VV2 Bt4C1_22610 ENOG4105SFS phosphoesterase RecJ domain protein Bt4C1_22640 ENOG4105DC7 peptidase M24 Bt4C1_22675 ENOG4105Z7P Acetyltransferase (GNAT) family Bt4C1_22680 ENOG41082W1 Cupin 2, conserved barrel domain protein Bt4C1_22695 ENOG4107YZX Universal stress protein Bt4C1_22735 ENOG4108JYZ YitT family Bt4C1_22755 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Bt4C1_22765 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Bt4C1_22770 ENOG4105KBJ sporulation protein ytfj Bt4C1_22785 ENOG4105EFZ amidohydrolase Bt4C1_22795 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Bt4C1_22820 ENOG4107RSM transcriptional regulator Bt4C1_22830 ENOG4105U5Y Transcriptional regulator Bt4C1_22840 ENOG4105C28 cystathionine Bt4C1_22875 ENOG4105EMN RNA polymerase sigma factor Bt4C1_22885 ENOG4108UW5 maltose o-acetyltransferase Bt4C1_22895 ENOG4105F1V Acetoin utilization protein Bt4C1_22900 ENOG4105W87 Cbs domain Bt4C1_22905 ENOG4105DGU Histone deacetylase Bt4C1_22920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Bt4C1_22925 ENOG4105BZU Histidine kinase Bt4C1_22930 ENOG4107SNB ankyrin repeat protein YahD Bt4C1_22935 ENOG4105EP9 oxidoreductase Bt4C1_22965 ENOG4105ETE Transcriptional regulator (LacI family Bt4C1_22975 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Bt4C1_22980 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Bt4C1_23000 ENOG4105C88 aminopeptidase Bt4C1_23020 ENOG4108IPJ Membrane Bt4C1_23055 ENOG4108VDD TRNA binding domain protein Bt4C1_23085 ENOG4105C8F Beta-lactamase domain protein Bt4C1_23100 ENOG4108V15 phosphotransferase enzyme family Bt4C1_23105 ENOG4108IUM Glycogen debranching enzyme Bt4C1_23115 ENOG4107QSE Dipeptidase Bt4C1_23120 ENOG4105YW5 deoR family transcriptional regulator Bt4C1_23135 ENOG4105CBX hi0933 family Bt4C1_23170 ENOG4108VJ1 Transcriptional regulator (CarD family Bt4C1_23175 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Bt4C1_23180 ENOG4105CSC Glucose uptake protein Bt4C1_23195 ENOG4108ZAF Molybdopterin Bt4C1_23200 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein Bt4C1_23205 ENOG4105CVM Molybdenum cofactor synthesis domain protein Bt4C1_23215 ENOG4105D06 uba thif-type nad fad binding protein Bt4C1_23220 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Bt4C1_23240 ENOG41085GJ domain protein Bt4C1_23250 ENOG4105DWV Homoserine O-trans-acetylase Bt4C1_23260 ENOG4108B31 Spore germination protein Bt4C1_23290 ENOG410605W Major Facilitator Bt4C1_23295 ENOG4107S91 Sodium hydrogen exchanger Bt4C1_23300 ENOG4105NCW Trka-c domain protein Bt4C1_23315 ENOG4105C19 ABC transporter Bt4C1_23335 ENOG4105N5T Radical SAM Protein Bt4C1_23360 ENOG4105E8V Alpha Beta Hydrolase Fold protein Bt4C1_23365 ENOG4108Z0R Transferase Bt4C1_23370 ENOG4105YVM Phosphoesterase, PA-phosphatase related Bt4C1_23375 ENOG4105BZF Glycosyl transferase (Group 1 Bt4C1_23385 ENOG4105EPU Molybdenum cofactor synthesis domain protein Bt4C1_23465 ENOG4105BZU Histidine kinase Bt4C1_23470 ENOG4105BZU Histidine kinase Bt4C1_23480 ENOG4107S9D Alpha beta hydrolase Bt4C1_23485 ENOG4107T7U Sulfatase Bt4C1_23510 ENOG4105D2X ABC transporter substrate-binding protein Bt4C1_23520 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component Bt4C1_23575 ENOG41080TC multidrug resistance protein Bt4C1_23580 ENOG410839T multidrug resistance protein Bt4C1_23600 ENOG4108V2W Carbonate dehydratase Bt4C1_23610 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Bt4C1_23655 ENOG41087YS Phage shock protein A Bt4C1_23680 ENOG4105N67 Proton-coupled thiamine transporter YuaJ Bt4C1_23685 ENOG4105BZU Histidine kinase Bt4C1_23690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_23715 ENOG4108UGV hypoxanthine phosphoribosyltransferase Bt4C1_23720 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) Bt4C1_23765 ENOG4107ZTW SNARE associated Golgi Bt4C1_23780 ENOG4105C19 ABC transporter Bt4C1_23785 ENOG41086D8 Transcriptional regulator Bt4C1_23795 ENOG4105CJ1 ABC, transporter Bt4C1_23805 ENOG41082BM Transcriptional regulator, arsr family Bt4C1_23850 ENOG4105C6Z Gluconate Bt4C1_23855 ENOG4105FDP GntR family transcriptional regulator Bt4C1_23875 ENOG41069H0 dihydroorotase EC 3.5.2.3 Bt4C1_23895 ENOG4105DTQ mandelate racemase muconate lactonizing Bt4C1_23905 ENOG4108IPT Naphthoate synthase Bt4C1_23910 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) Bt4C1_23920 ENOG4105E4F Isochorismate synthase Bt4C1_23925 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase Bt4C1_23935 ENOG4105VEQ Cold shock protein Bt4C1_23975 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) Bt4C1_23990 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Bt4C1_23995 ENOG4108Q5F Tetr family transcriptional regulator Bt4C1_24140 ENOG4105KT7 mgtC SapB transporter Bt4C1_24145 ENOG4107PBV potassium channel Bt4C1_24160 ENOG4105WG9 Conserved Protein Bt4C1_24170 ENOG4105CHM Aminotransferase Bt4C1_24175 ENOG4108ZB6 transcriptional regulator AsnC family Bt4C1_24180 ENOG4105C5I Dehydrogenase Bt4C1_24185 ENOG4108MUZ hydrolase Bt4C1_24195 ENOG4105C87 Aminotransferase class I and II Bt4C1_24210 ENOG4105Y38 Kinase-associated protein B Bt4C1_24220 ENOG4107R3E Citrate transporter Bt4C1_24235 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Bt4C1_24240 ENOG4105KA0 thioesterase Superfamily protein Bt4C1_24255 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Bt4C1_24275 ENOG41069ER domain protein Bt4C1_24290 ENOG4105CEP NADH dehydrogenase Bt4C1_24315 ENOG4105EWC Purine nucleoside phosphorylase Bt4C1_24340 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Bt4C1_24365 ENOG4108JJA ABC, transporter Bt4C1_24370 ENOG4105C4B ABC transporter, permease Bt4C1_24375 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Bt4C1_24430 ENOG41083MR nifu domain-containing protein Bt4C1_24445 ENOG4108W5N phosphatidylglycerophosphatase a Bt4C1_24465 ENOG4105DAX Pfam:DUF2983 Bt4C1_24475 ENOG4105DYS nad(p)h dehydrogenase (quinone) Bt4C1_24480 ENOG4105D4U had-superfamily hydrolase, subfamily iia Bt4C1_24495 ENOG4105CBT Fructose-1,6-bisphosphatase Bt4C1_24510 ENOG4105MMD transcriptional regulator Bt4C1_24515 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Bt4C1_24520 ENOG4107TXC Transcriptional regulator Bt4C1_24525 ENOG41090T1 Membrane Bt4C1_24550 ENOG4105FAA peptidase M23 Bt4C1_24555 ENOG4108YTE sporulation protein YunB Bt4C1_24560 ENOG4105KZD Domain of unknown function (DUF1805) Bt4C1_24565 ENOG4107R8B 5'-nucleotidase Bt4C1_24570 ENOG4105DIW FeS assembly protein SUFB Bt4C1_24575 ENOG4108UNV SUF system FeS assembly protein, NifU family Bt4C1_24580 ENOG4105C9B Cysteine desulfurase Bt4C1_24585 ENOG4105JRK feS assembly protein SufD Bt4C1_24590 ENOG4105C3K feS assembly ATPase SufC Bt4C1_24595 ENOG4105D01 (LipO)protein Bt4C1_24600 ENOG4105D01 (LipO)protein Bt4C1_24605 ENOG4108UMI ABC transporter, permease Bt4C1_24610 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Bt4C1_24635 ENOG41080E8 Transcriptional regulator, Spx MgsR family Bt4C1_24655 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Bt4C1_24670 ENOG4108W8B Beta-lactamase domain protein Bt4C1_24675 ENOG4105C1G acyl-Coa dehydrogenase Bt4C1_24680 ENOG4105CHU acetyl-coa acetyltransferase Bt4C1_24695 ENOG4105DZ1 carboxypeptidase Bt4C1_24715 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer Bt4C1_24730 ENOG4108SUT Major Facilitator Superfamily Bt4C1_24735 ENOG4107R7I amino acid Bt4C1_24750 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Bt4C1_24760 ENOG4107AYK membrAne Bt4C1_24790 ENOG4107ZTW SNARE associated Golgi Bt4C1_24800 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein Bt4C1_24805 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_24810 ENOG4105BZU Histidine kinase Bt4C1_24835 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_24840 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_24845 ENOG4105VG1 fes assembly suf system protein Bt4C1_24850 ENOG4105D4Y metalloprotease Bt4C1_24855 ENOG4105C2I pirin domain protein Bt4C1_24870 ENOG4107T5V SNARE associated Golgi Bt4C1_24875 ENOG4107S91 Sodium hydrogen exchanger Bt4C1_24880 ENOG4105NCW Trka-c domain protein Bt4C1_24890 ENOG4108RMU ferritin dps family protein Bt4C1_24905 ENOG4108URH decarboxylase Bt4C1_24915 ENOG41090A1 ferritin Bt4C1_24925 ENOG4105D9N nucleoside Bt4C1_24930 ENOG4105D9N nucleoside Bt4C1_24945 ENOG4108RYK Nad-dependent epimerase dehydratase Bt4C1_24960 ENOG4105CV8 reductase Bt4C1_24965 ENOG4105F27 Major Facilitator Bt4C1_24970 ENOG4105KVH Transcriptional regulator Bt4C1_24985 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Bt4C1_24990 ENOG4105D4A Cell wall formation (By similarity) Bt4C1_25015 ENOG4105WMR Protein CrcB homolog Bt4C1_25035 ENOG4105C5H ABC transporter Bt4C1_25040 ENOG4108MK9 spermidine N(1)-acetyltransferase Bt4C1_25050 ENOG4108VY7 phosphate-starvation-inducible protein PsiE Bt4C1_25060 ENOG4108W2Y isochorismatase Bt4C1_25080 ENOG4108V2W Carbonate dehydratase Bt4C1_25085 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) Bt4C1_25105 ENOG4108IPW abc transporter atp-binding protein Bt4C1_25110 ENOG4105CM4 permease protein Bt4C1_25145 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Bt4C1_25155 ENOG4105XZU Preprotein translocase, subunit SecG Bt4C1_25160 ENOG41067MG lrgb family Bt4C1_25210 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Bt4C1_25235 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Bt4C1_25455 ENOG4105VTR Integrase Bt4C1_25530 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Bt4C1_25545 ENOG41090VF Stage v sporulation protein ac Bt4C1_25550 ENOG4105CZ3 stage V sporulation protein ad Bt4C1_25565 ENOG4108QY0 Membrane Bt4C1_25570 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Bt4C1_25575 ENOG4105KRI phosphocarrier protein (HPr Bt4C1_25585 ENOG4105CHW UPF0052 protein Bt4C1_25595 ENOG4108Z4K mutator MutT protein Bt4C1_25605 ENOG4105C3M thioredoxin reductase Bt4C1_25615 ENOG4108S4C acetyltransferase Bt4C1_25635 ENOG41086DT Membrane protein of unknown function Bt4C1_25645 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Bt4C1_25665 ENOG4107TXC Transcriptional regulator Bt4C1_25680 ENOG4105HMI Membrane Bt4C1_25685 ENOG4105DUM transcriptional regulator, lysR family Bt4C1_25695 ENOG4108WS4 fmn reductase Bt4C1_25700 ENOG4105C5H ABC transporter Bt4C1_25710 ENOG4105BZ1 (ABC) transporter Bt4C1_25720 ENOG4105CN1 protease Bt4C1_25725 ENOG4105CRP Part of the ABC transporter FtsEX involved in Bt4C1_25730 ENOG4105CAK Cell division ATP-binding protein ftsE Bt4C1_25740 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Bt4C1_25750 ENOG4105MS2 ribosomal subunit Interface protein Bt4C1_25755 ENOG4105VEQ Cold shock protein Bt4C1_25760 ENOG41081UC Inherit from COG: Competence protein Bt4C1_25785 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase Bt4C1_25790 ENOG4105XSJ toxin secretion phage lysis holin Bt4C1_26000 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Bt4C1_26005 ENOG4108C33 Resolvase Bt4C1_26015 ENOG4105K4H Nlp p60 protein Bt4C1_26020 ENOG4105KVH Transcriptional regulator Bt4C1_26030 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Bt4C1_26035 ENOG4108KGH TRANSCRIPTIONal Bt4C1_26040 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase Bt4C1_26045 ENOG4105C6Y Udp-glucose 6-dehydrogenase Bt4C1_26050 ENOG4105ESV Glycosyl transferase, family 4 Bt4C1_26060 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Bt4C1_26080 ENOG4105F8D glycoside hydrolase family 4 Bt4C1_26085 ENOG4105VCP PTS System Bt4C1_26090 ENOG4105CK1 PTS System Bt4C1_26100 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Bt4C1_26105 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) Bt4C1_26110 ENOG4105VCP PTS System Bt4C1_26120 ENOG4105VZJ PTS System Bt4C1_26140 ENOG4105ECB domain protein Bt4C1_26145 ENOG4107RSM transcriptional regulator Bt4C1_26180 ENOG4105DAA L-lactate Bt4C1_26190 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) Bt4C1_26200 ENOG4105E0M Sulfatase Bt4C1_26225 ENOG4107R8N Glycosyl transferase, family 2 Bt4C1_26235 ENOG4105C94 Transporter Bt4C1_26240 ENOG41069ER domain protein Bt4C1_26265 ENOG4105KBK Zinc finger, swim domain protein Bt4C1_26270 ENOG4105C0D helicase Bt4C1_26300 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Bt4C1_26310 ENOG4107RBB ABC transporter, permease Bt4C1_26315 ENOG4105C19 ABC transporter Bt4C1_26325 ENOG4105CXY transporter Bt4C1_26340 ENOG4105BZU Histidine kinase Bt4C1_26345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_26355 ENOG4108KGH TRANSCRIPTIONal Bt4C1_26365 ENOG4105C6Y Udp-glucose 6-dehydrogenase Bt4C1_26390 ENOG4105D3Q Sugar transferase Bt4C1_26395 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Bt4C1_26400 ENOG4108RB3 Capsular polysaccharide biosynthesis protein Bt4C1_26405 ENOG4107YJ4 chain length determinant protein Bt4C1_26410 ENOG4105HTX biosynthesis protein Bt4C1_26415 ENOG4107YJ4 chain length determinant protein Bt4C1_26430 ENOG4105MT0 Sporulation transcriptional regulator spoiiid Bt4C1_26440 ENOG4105FRN stage II sporulation protein Bt4C1_26455 ENOG4105DY9 regulatoR Bt4C1_26475 ENOG4106778 Protein of unknown function (DUF1146) Bt4C1_26480 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Bt4C1_26485 ENOG4105C8S subunit m Bt4C1_26490 ENOG4105D65 subunit l Bt4C1_26515 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Bt4C1_26520 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Bt4C1_26530 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Bt4C1_26535 ENOG4105BZU Histidine kinase Bt4C1_26585 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) Bt4C1_26590 ENOG41062M3 atp synthase Bt4C1_26610 ENOG4108UIC UPF0340 protein Bt4C1_26615 ENOG4108YZG isomerase Bt4C1_26630 ENOG4108VGI doxx family Bt4C1_26635 ENOG4107XC4 flavin reductase domain protein, FMN-binding Bt4C1_26650 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Bt4C1_26660 ENOG4108ZXQ stage ii sporulation protein r Bt4C1_26665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Bt4C1_26670 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Bt4C1_26685 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Bt4C1_26690 ENOG4105CBT Fructose-1,6-bisphosphatase Bt4C1_26695 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Bt4C1_26730 ENOG4105C1G acyl-Coa dehydrogenase Bt4C1_26735 ENOG4105C1G acyl-Coa dehydrogenase Bt4C1_26740 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Bt4C1_26750 ENOG4105DF6 Fe-S oxidoreductase Bt4C1_26765 ENOG4105BZU Histidine kinase Bt4C1_26780 ENOG4105D4Y metalloprotease Bt4C1_26790 ENOG4105BZU Histidine kinase Bt4C1_26795 ENOG4105KCT ABC transporter Bt4C1_26800 ENOG4108M15 ABC transporter Bt4C1_26805 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) Bt4C1_26815 ENOG4105IIU Aminopeptidase Bt4C1_26835 ENOG4105EMN RNA polymerase sigma factor Bt4C1_26845 ENOG410684U Domain of unknown function (DUF1934) Bt4C1_26865 ENOG4105CYW agmatinase Bt4C1_26875 ENOG4105DXB Major Facilitator superfamily Bt4C1_26880 ENOG4107SWG transcriptional regulator MERR family Bt4C1_26885 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Bt4C1_26890 ENOG4105BZ4 penicillin-binding protein Bt4C1_26895 ENOG4108XFG YwhD family Bt4C1_26900 ENOG4108Z4T Peptidase M50 Bt4C1_26905 ENOG41069HH 4-oxalocrotonate tautomerase Bt4C1_26910 ENOG4105DCI Phosphohydrolase Bt4C1_26915 ENOG4108MES Periplasmic binding protein Bt4C1_26920 ENOG4105E0A ABC, transporter Bt4C1_26925 ENOG4105EHG Permease protein Bt4C1_26930 ENOG4105DQ5 transport system permease protein Bt4C1_26940 ENOG4108VCI transcription factor, rsfa family Bt4C1_26945 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) Bt4C1_26950 ENOG4108IJ2 phosphate acetyltransferase Bt4C1_26955 ENOG4107UEZ chlorite dismutase Bt4C1_26965 ENOG4108VKI Cell wall hydrolase Bt4C1_26985 ENOG4107SVH Potassium channel protein Bt4C1_26995 ENOG410667J hydrolase Bt4C1_27000 ENOG4105VCH membrane Bt4C1_27010 ENOG4108TU7 Inherit from COG: (ABC) transporter Bt4C1_27015 ENOG4105CJ1 ABC, transporter Bt4C1_27020 ENOG41090WU lipolytic protein G-D-S-L family Bt4C1_27035 ENOG4105D6E homoserine dehydrogenase Bt4C1_27055 ENOG4108Y4K DNA-binding transcriptional activator Bt4C1_27065 ENOG4105WH1 Two component transcriptional regulator luxr family Bt4C1_27070 ENOG4105BZU Histidine kinase Bt4C1_27075 ENOG4105DWF phosphomethylpyrimidine kinase Bt4C1_27080 ENOG4105BZU Histidine kinase Bt4C1_27085 ENOG4105VCD cytoplasmic protein Bt4C1_27090 ENOG4105D22 carbon starvation protein Bt4C1_27095 ENOG4105DY9 regulatoR Bt4C1_27100 ENOG41079KZ Major Facilitator Superfamily Bt4C1_27110 ENOG4105CG5 Glycosyl transferase (Group 1 Bt4C1_27120 ENOG4105EN6 Membrane Bt4C1_27125 ENOG4106YBV Methyl-accepting chemotaxis Bt4C1_27135 ENOG4108S4H thioesterase Superfamily protein Bt4C1_27140 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Bt4C1_27155 ENOG4105K64 Glycosyl transferase, family 2 Bt4C1_27165 ENOG4105EJV Membrane Bt4C1_27170 ENOG4105CKK Glycosyl transferase, family 2 Bt4C1_27180 ENOG4108IG5 Transcriptional regulator Bt4C1_27185 ENOG4105C5H ABC transporter Bt4C1_27190 ENOG41067SE Tetr family transcriptional regulator Bt4C1_27200 ENOG4105E0X reductase Bt4C1_27205 ENOG4106F5Q Membrane Bt4C1_27220 ENOG4108NEV two component transcriptional regulator, LytTR family Bt4C1_27225 ENOG4108HRK Histidine kinase Bt4C1_27230 ENOG4107RGD Major Facilitator superfamily Bt4C1_27245 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Bt4C1_27255 ENOG4105IW1 AmiS UreI transporter Bt4C1_27265 ENOG4105CMR udp-glucose 4-epimerase Bt4C1_27270 ENOG4108UT2 hemolysin iii Bt4C1_27280 ENOG4105C1J atp-dependent rna helicase Bt4C1_27285 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) Bt4C1_27290 ENOG4105DPN Oligoendopeptidase f Bt4C1_27305 ENOG4105BZU Histidine kinase Bt4C1_27385 ENOG4105C0H protease Bt4C1_27390 ENOG4105Q2H domain protein Bt4C1_27405 ENOG4105BZU Histidine kinase Bt4C1_27410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Bt4C1_27435 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Bt4C1_27440 ENOG4105CDU Replicative dna helicase Bt4C1_27450 ENOG4105BZR domain protein Bt4C1_27455 ENOG4108XMW Membrane Bt4C1_27465 ENOG4108UUM single-stranded DNA-binding protein Bt4C1_27475 ENOG4105C3G gtp-binding protein Bt4C1_27480 ENOG4105VDK protein, conserved in bacteria Bt4C1_27485 ENOG4105D8X mechanosensitive ion channel Bt4C1_27490 ENOG4108ZDA Sporulation protein YyaC Bt4C1_27495 ENOG4105FA0 parb-like partition protein Bt4C1_27500 ENOG4107QJE Chromosome Partitioning Protein Bt4C1_27520 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Bt4C1_27530 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Bt4C1_27550 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Bt4C1_27555 ENOG410848D S4 domain protein YaaA Bt4C1_27570 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Bt4C1_27660 ENOG4107AYK membrAne Bt4C1_27665 ENOG4107RSM transcriptional regulator Bt4C1_27680 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Bt4C1_27695 ENOG4108J59 Extracellular solute-binding protein, family 5 Bt4C1_27705 ENOG4105KRN Transcriptional regulator, abrb family Bt4C1_27720 ENOG4105K70 DNA-binding protein Bt4C1_27735 ENOG4105EKQ RNA-directed DNA polymerase Bt4C1_27765 ENOG4106A3M Cytochrome p-450 Bt4C1_27770 ENOG410625E Bt4C1_27785 ENOG4105DHF Membrane Bt4C1_27850 ENOG4105EKQ RNA-directed DNA polymerase Bt4C1_27865 ENOG4105EKQ RNA-directed DNA polymerase Bt4C1_28065 ENOG4105EKQ RNA-directed DNA polymerase Bt4C1_28070 ENOG4105EKQ RNA-directed DNA polymerase Bt4C1_28110 ENOG4105CK5 oxidoreductase Bt4C1_28330 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Bt4C1_28360 ENOG4105D7V transposase Bt4C1_28370 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) Bt4C1_28375 ENOG4105NA0 Transcriptional regulator Bt4C1_28395 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase Bt4C1_28405 ENOG4105D7V transposase Bt4C1_28445 ENOG41082BM Transcriptional regulator, arsr family Bt4C1_28480 ENOG4108MRH transcriptional regulatory protein Bt4C1_28485 ENOG4105C5I Dehydrogenase Bt4C1_28530 ENOG4105D7V transposase Bt4C1_28540 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_28545 ENOG4105NCW Trka-c domain protein Bt4C1_28550 ENOG4107S91 Sodium hydrogen exchanger Bt4C1_28555 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase Bt4C1_28565 ENOG4105C8Q Methyl-accepting chemotaxis Bt4C1_28585 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) Bt4C1_28620 ENOG4105XSJ toxin secretion phage lysis holin Bt4C1_28645 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase Bt4C1_28685 ENOG4105EKQ RNA-directed DNA polymerase Bt4C1_28900 ENOG4108J59 Extracellular solute-binding protein, family 5 Bt4C1_28935 ENOG410780I phosphoprotein phosphatase activity Bt4C1_28965 ENOG4105C9U ATP-dependent DNA helicase RecQ Bt4C1_29090 ENOG4105K4H Nlp p60 protein Bt4C1_29245 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Bt4C1_29275 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Bt4C1_29390 ENOG4105C7H Helicase, RecD TraA family