locus-tag class description CT43_CH0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CT43_CH0003 ENOG410848D S4 domain protein YaaA CT43_CH0006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CT43_CH0008 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CT43_CH0014 ENOG4105ZMH deoxynucleoside kinase CT43_CH0016 ENOG4105GTG Isochorismatase CT43_CH0017 ENOG4108Z6B deaminase CT43_CH0018 ENOG4105C6E dna polymerase iii CT43_CH0022 ENOG41067KS pro-sigma K processing CT43_CH0024 ENOG4105CXN decarboxylase CT43_CH0026 ENOG4105FA2 dna polymerase iii CT43_CH0027 ENOG4105MA4 psp1 domain protein CT43_CH0029 ENOG41060K3 Methyltransferase CT43_CH0031 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CT43_CH0032 ENOG4105KRN Transcriptional regulator, abrb family CT43_CH0033 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CT43_CH0034 ENOG4105F8V Hydrolase, tatD family CT43_CH0035 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) CT43_CH0037 ENOG4105XFA sporulation peptidase YabG CT43_CH0038 ENOG4105W42 Veg protein CT43_CH0041 ENOG4105DFT pur operon repressor CT43_CH0042 ENOG4105KME endoribonuclease L-psp CT43_CH0045 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CT43_CH0046 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CT43_CH0048 ENOG4108JA2 transcriptioN-repair coupling factor CT43_CH0049 ENOG4108M14 stage v sporulation protein t CT43_CH0051 ENOG4108IY2 MazG family CT43_CH0052 ENOG41082I2 s4 domain protein CT43_CH0053 ENOG4105VYY sporulation protein yabp CT43_CH0056 ENOG41060GV RNA binding s1 domain protein CT43_CH0058 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CT43_CH0059 ENOG4108UGV hypoxanthine phosphoribosyltransferase CT43_CH0060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CT43_CH0063 ENOG4105C6T cysteine synthase CT43_CH0064 ENOG4105CRQ synthase (Component I) CT43_CH0065 ENOG4105DDQ anthranilate synthase CT43_CH0066 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CT43_CH0067 ENOG4105EEI dihydropteroate synthase CT43_CH0068 ENOG4105KRF dihydroneopterin aldolase CT43_CH0069 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CT43_CH0071 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CT43_CH0073 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CT43_CH0076 ENOG4108Z0C Uvrb UvrC protein CT43_CH0079 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CT43_CH0081 ENOG4105CTP PilT protein domain protein CT43_CH0085 ENOG4105D7W serine acetyltransferase CT43_CH0088 ENOG4105C2N RNA methyltransferase TrmH family group 3 CT43_CH0089 ENOG4105M0M Tetracycline resistance protein CT43_CH0090 ENOG4105QIV RNA polymerase CT43_CH0093 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CT43_CH0097 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CT43_CH0098 ENOG4107Y49 methyltransferase CT43_CH0100 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CT43_CH0101 ENOG4105XPM ribosomal protein CT43_CH0123 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CT43_CH0128 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CT43_CH0130 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CT43_CH0132 ENOG41067V7 50S ribosomal protein L36 CT43_CH0137 ENOG4108JJB ABC transporter CT43_CH0138 ENOG4108JJB ABC transporter CT43_CH0139 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CT43_CH0140 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CT43_CH0145 ENOG4105D1F ATP-binding protein CT43_CH0148 ENOG4108NMV polysaccharide deacetylase CT43_CH0152 ENOG4105C8B TIGR00159 family CT43_CH0153 ENOG4107U5W ybbr family CT43_CH0156 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CT43_CH0161 ENOG4108PSK reductase CT43_CH0162 ENOG4108UMI ABC transporter, permease CT43_CH0163 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CT43_CH0164 ENOG4105D01 (LipO)protein CT43_CH0165 ENOG4105CB2 alcohol dehydrogenase CT43_CH0167 ENOG4105IQ5 FAD linked oxidase domain protein CT43_CH0170 ENOG4105C2C drug resistance transporter, Bcr CflA CT43_CH0174 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CT43_CH0175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CT43_CH0176 ENOG4105C3U ABC transporter CT43_CH0177 ENOG4108JQ7 (ABC) transporter CT43_CH0181 ENOG4108J59 Extracellular solute-binding protein, family 5 CT43_CH0182 ENOG4108J59 Extracellular solute-binding protein, family 5 CT43_CH0185 ENOG4106Z1T Nicotinamide Mononucleotide Transporter CT43_CH0188 ENOG4105E0C molybdate abc transporter CT43_CH0189 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CT43_CH0190 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CT43_CH0191 ENOG4105EGI Transcriptional regulator CT43_CH0194 ENOG4105F6E Acyl-transferase CT43_CH0196 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CT43_CH0200 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CT43_CH0204 ENOG4105C5H ABC transporter CT43_CH0205 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CT43_CH0207 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CT43_CH0208 ENOG4105C3U ABC transporter CT43_CH0209 ENOG4108JQ7 (ABC) transporter CT43_CH0210 ENOG410667J hydrolase CT43_CH0213 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CT43_CH0214 ENOG4105ERH Fumarylacetoacetate hydrolase CT43_CH0216 ENOG4105CUB amino acid CT43_CH0218 ENOG4108SC4 )-transporter CT43_CH0219 ENOG4105CPF Cell wall formation (By similarity) CT43_CH0220 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CT43_CH0225 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CT43_CH0226 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CT43_CH0228 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CT43_CH0232 ENOG4105K8N protein family UPF0079, ATPase CT43_CH0233 ENOG41072GX Peptidase M22 Glycoprotease CT43_CH0234 ENOG410801F ribosomal-protein-alanine acetyltransferase CT43_CH0235 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CT43_CH0236 ENOG4105C5H ABC transporter CT43_CH0239 ENOG4108TYN CAAX amino terminal protease family protein CT43_CH0243 ENOG4107EV6 Inherit from COG: YD repeat protein CT43_CH0246 ENOG4105C7N Xanthine uracil vitamin C permease CT43_CH0248 ENOG4105BZU Histidine kinase CT43_CH0250 ENOG4107ZXU DSBA oxidoreductase CT43_CH0258 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) CT43_CH0261 ENOG4105SX7 Transporter CT43_CH0264 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CT43_CH0265 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CT43_CH0266 ENOG4105C83 adenylosuccinate lyase CT43_CH0268 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CT43_CH0273 ENOG4108V3E phosphoribosylglycinamide formyltransferase CT43_CH0275 ENOG4105C12 Phosphoribosylglycinamide synthetase CT43_CH0277 ENOG4105EGI Transcriptional regulator CT43_CH0282 ENOG4105C4R Atp-dependent dna helicase CT43_CH0283 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CT43_CH0287 ENOG4108W2Y isochorismatase CT43_CH0288 ENOG4108IDU Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CT43_CH0289 ENOG4108UMI ABC transporter, permease CT43_CH0290 ENOG4105D01 (LipO)protein CT43_CH0293 ENOG410834F Transcriptional regulator CT43_CH0294 ENOG4107I77 yiaA/B two helix domain CT43_CH0298 ENOG4105CBD Diacylglycerol kinase CT43_CH0300 ENOG4108JPW Aminotransferase CT43_CH0302 ENOG4105C26 Dehydrogenase CT43_CH0303 ENOG4105KPY Small multidrug resistance protein CT43_CH0309 ENOG4105D9N nucleoside CT43_CH0310 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CT43_CH0312 ENOG4108W15 Protein of unknown function (DUF1456) CT43_CH0315 ENOG4105DTQ mandelate racemase muconate lactonizing CT43_CH0317 ENOG4105DFD Na H antiporter CT43_CH0322 ENOG4105D3R alkyl hydroperoxide reductase CT43_CH0323 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CT43_CH0324 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CT43_CH0325 ENOG4107W7X Aldolase CT43_CH0326 ENOG4105EHG Permease protein CT43_CH0327 ENOG4105DQ5 transport system permease protein CT43_CH0328 ENOG4108V5C ABC transporter CT43_CH0329 ENOG4105CAY ferredoxin--nadp reductase CT43_CH0332 ENOG4106UIA CT43_CH0333 ENOG4106UIA CT43_CH0336 ENOG4105BZU Histidine kinase CT43_CH0340 ENOG410756H nucleotidyltransferase CT43_CH0344 ENOG4105E5Q amino acid AbC transporter CT43_CH0346 ENOG4105EAB amino acid AbC transporter CT43_CH0348 ENOG4105C8Q Methyl-accepting chemotaxis CT43_CH0351 ENOG4105DBV ornithine carbamoyltransferase CT43_CH0353 ENOG4105C5B carbamate kinase CT43_CH0354 ENOG4108W63 CRP FNR family transcriptional regulator CT43_CH0356 ENOG4105DNP FAD linked oxidase domain protein CT43_CH0358 ENOG4105CI1 PTS System CT43_CH0361 ENOG4105C9U ATP-dependent DNA helicase RecQ CT43_CH0364 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CT43_CH0368 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CT43_CH0369 ENOG4105D2X ABC transporter substrate-binding protein CT43_CH0371 ENOG4105C5H ABC transporter CT43_CH0377 ENOG41062JF Transcriptional regulator CT43_CH0380 ENOG4105DEU major facilitator superfamily CT43_CH0383 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CT43_CH0386 ENOG4108N0M stress protein CT43_CH0387 ENOG4106FN3 tellurium resistance protein CT43_CH0388 ENOG4106FN3 tellurium resistance protein CT43_CH0389 ENOG4107TS3 membrane protein, TerC CT43_CH0390 ENOG4108TTB tellurium resistance protein CT43_CH0393 ENOG41068PA UPF0435 protein CT43_CH0394 ENOG4105KJF protein tyrosine phosphatase CT43_CH0396 ENOG4107U9T Pfam:Ribonuclease_BN CT43_CH0397 ENOG4105C59 p-type ATPase CT43_CH0398 ENOG4108IPJ Membrane CT43_CH0402 ENOG4107ZTW SNARE associated Golgi CT43_CH0405 ENOG410606W general stress protein CT43_CH0406 ENOG4105UPD Calcium Proton CT43_CH0413 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CT43_CH0414 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CT43_CH0416 ENOG4108JUB Transcriptional regulator CT43_CH0418 ENOG4108IQI permease CT43_CH0425 ENOG4108A04 Beta-lactamase CT43_CH0428 ENOG4107R51 Glycosyl transferase, family 2 CT43_CH0429 ENOG4107QQG Dehydrogenase CT43_CH0430 ENOG4105C3I Nad-dependent epimerase dehydratase CT43_CH0431 ENOG4105CKK Glycosyl transferase, family 2 CT43_CH0433 ENOG4105F1A Pyruvate formate-lyase CT43_CH0437 ENOG4105CI2 imidazolone-5-propionate hydrolase CT43_CH0438 ENOG4105ECP epimerase CT43_CH0443 ENOG41067AE Membrane-bound metal-dependent hydrolase CT43_CH0444 ENOG4105CEN a g-specific adenine glycosylase CT43_CH0445 ENOG4106BXE CT43_CH0450 ENOG4105BZ1 (ABC) transporter CT43_CH0451 ENOG4107NBY Membrane CT43_CH0452 ENOG4105CBC glutamate synthase CT43_CH0454 ENOG4108IUW ABC transporter CT43_CH0458 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CT43_CH0459 ENOG4105G5W regulator Fur family CT43_CH0465 ENOG4108JQC penicillin-binding protein 1A CT43_CH0466 ENOG4108R9S DSBA oxidoreductase CT43_CH0467 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CT43_CH0469 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CT43_CH0470 ENOG4105BZU Histidine kinase CT43_CH0471 ENOG4105CYN Serine protein kinase CT43_CH0475 ENOG4105C94 Transporter CT43_CH0478 ENOG4105DZ6 Band 7 protein CT43_CH0480 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CT43_CH0481 ENOG4108V9W transcriptional regulatory protein CT43_CH0482 ENOG4105D4T Citrate transporter CT43_CH0487 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CT43_CH0488 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CT43_CH0489 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CT43_CH0490 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CT43_CH0491 ENOG4105BZ7 extracellular solute-binding protein family 1 CT43_CH0492 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CT43_CH0493 ENOG4108STX response regulator CT43_CH0494 ENOG4105US7 Histidine kinase CT43_CH0499 ENOG4108MRH transcriptional regulatory protein CT43_CH0501 ENOG4105C6K Malic enzyme CT43_CH0503 ENOG4108UZ3 Transporter CT43_CH0504 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CT43_CH0506 ENOG4105BZU Histidine kinase CT43_CH0507 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH0510 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CT43_CH0511 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CT43_CH0512 ENOG4108JB9 formate dehydrogenase CT43_CH0516 ENOG4105CUB amino acid CT43_CH0518 ENOG4105C59 p-type ATPase CT43_CH0519 ENOG4105DAP Nicotinate phosphoribosyltransferase CT43_CH0526 ENOG41073R8 VanW family CT43_CH0527 ENOG4108KGH TRANSCRIPTIONal CT43_CH0528 ENOG4105D9N nucleoside CT43_CH0529 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CT43_CH0530 ENOG4105C37 (CBS) domain CT43_CH0531 ENOG4108IJ0 Aspartate ammonia-lyase CT43_CH0532 ENOG4105DAA L-lactate CT43_CH0535 ENOG4105DUX Transporter CT43_CH0536 ENOG4108MES Periplasmic binding protein CT43_CH0537 ENOG4105DQ5 transport system permease protein CT43_CH0538 ENOG4108IHU transport system permease protein CT43_CH0539 ENOG4105E0A ABC, transporter CT43_CH0542 ENOG4105EXW epimerase dehydratase CT43_CH0544 ENOG4107T89 von Willebrand factor, type A CT43_CH0545 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CT43_CH0546 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CT43_CH0548 ENOG4105BZU Histidine kinase CT43_CH0549 ENOG4105D5Q Arginine ornithine antiporter CT43_CH0550 ENOG4107414 GntR family transcriptional regulator CT43_CH0551 ENOG4105C5Y PTS System CT43_CH0552 ENOG4105CG3 alpha amylase, catalytic region CT43_CH0555 ENOG4105E1K spore germination protein CT43_CH0557 ENOG4105CRN Aminoglycoside phosphotransferase CT43_CH0558 ENOG4105BZG amino acid carrier protein CT43_CH0559 ENOG4105CDA abc transporter atp-binding protein CT43_CH0560 ENOG4105CT1 (ABC) transporter CT43_CH0561 ENOG4105EAD ABC transporter CT43_CH0562 ENOG4105DRP amino acid AbC transporter CT43_CH0563 ENOG4105EKQ RNA-directed DNA polymerase CT43_CH0564 ENOG4108IQI permease CT43_CH0567 ENOG4105GFR rna polymerase sigma factor CT43_CH0569 ENOG4105D29 Helix-turn-helix type 11 domain protein CT43_CH0570 ENOG4105NAE bifunctional deaminase-reductase domain protein CT43_CH0571 ENOG4105BZU Histidine kinase CT43_CH0577 ENOG4105CHH sulfate transporter CT43_CH0578 ENOG41068KF Universal stress protein CT43_CH0580 ENOG4105DEF Extracellular solute-binding protein, family 5 CT43_CH0582 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CT43_CH0583 ENOG4108JQ7 (ABC) transporter CT43_CH0585 ENOG4105CXY transporter CT43_CH0586 ENOG41067TZ transcriptional regulator, MarR family CT43_CH0587 ENOG4105C0R drug resistance transporter emrb qaca subfamily CT43_CH0588 ENOG4105ETE Transcriptional regulator (LacI family CT43_CH0589 ENOG4108RVA ribokinase CT43_CH0591 ENOG4105C2J ABC transporter CT43_CH0592 ENOG4105CNN ABC, transporter CT43_CH0593 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CT43_CH0594 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CT43_CH0601 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) CT43_CH0603 ENOG4108IMY Transcriptional regulator CT43_CH0610 ENOG4108NF7 phage-type endonuclease CT43_CH0611 ENOG4108PNI recT protein CT43_CH0620 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH0623 ENOG4105WXW Antirepressor CT43_CH0628 ENOG4108C33 Resolvase CT43_CH0646 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CT43_CH0650 ENOG4105CNU cell division protein FtsK CT43_CH0658 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CT43_CH0659 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CT43_CH0660 ENOG41069ER domain protein CT43_CH0661 ENOG4105VZ8 Transcriptional regulator CT43_CH0662 ENOG4107D63 CT43_CH0670 ENOG4105C85 amino acid CT43_CH0671 ENOG4105C7N Xanthine uracil vitamin C permease CT43_CH0674 ENOG4105MA6 gCN5-related N-acetyltransferase CT43_CH0678 ENOG4105CCU oxidase (Subunit III) CT43_CH0679 ENOG4105BZ9 Cytochrome C oxidase, subunit I CT43_CH0680 ENOG4105E2S oxidase) subunit II CT43_CH0685 ENOG4106CAD Protein of unknown function (DUF3311) CT43_CH0686 ENOG4105E1V na solute symporter CT43_CH0689 ENOG4108NHD germination protein CT43_CH0691 ENOG4105CE1 Ferrous iron transport protein b CT43_CH0692 ENOG4105CE1 Ferrous iron transport protein b CT43_CH0693 ENOG4105CE1 Ferrous iron transport protein b CT43_CH0694 ENOG4105CVA phosphate CT43_CH0695 ENOG4105C8U phosphate abc transporter CT43_CH0696 ENOG4105E2Z phosphate ABC transporter (Permease CT43_CH0699 ENOG41080XQ Signal transduction protein with cbs domains CT43_CH0703 ENOG4105ETU transcriptional activator (TenA CT43_CH0705 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CT43_CH0707 ENOG4108VEU Thiamine monophosphate synthase CT43_CH0708 ENOG41080HI glycine oxidase CT43_CH0711 ENOG4105D06 uba thif-type nad fad binding protein CT43_CH0712 ENOG4105DWF phosphomethylpyrimidine kinase CT43_CH0717 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CT43_CH0720 ENOG4108INS Transcriptional regulator CT43_CH0723 ENOG4105C7N Xanthine uracil vitamin C permease CT43_CH0725 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CT43_CH0729 ENOG4105C5Y PTS System CT43_CH0732 ENOG4105K63 Thioredoxin CT43_CH0736 ENOG4108B31 Spore germination protein CT43_CH0740 ENOG4107Y03 Nitroreductase CT43_CH0741 ENOG4105ED1 spovr family CT43_CH0743 ENOG4105J4Q Transcriptional regulator CT43_CH0746 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CT43_CH0747 ENOG4105XTG Pfam:DUF156 CT43_CH0748 ENOG4105VFE sira family CT43_CH0749 ENOG4107TPS domain protein CT43_CH0750 ENOG4105VFE sira family CT43_CH0751 ENOG41085GJ domain protein CT43_CH0753 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CT43_CH0754 ENOG41087NI Sulfite exporter TauE/SafE CT43_CH0756 ENOG4108KGH TRANSCRIPTIONal CT43_CH0761 ENOG4105EMD TRANSCRIPTIONal CT43_CH0762 ENOG4105VCP PTS System CT43_CH0763 ENOG4105VZJ PTS System CT43_CH0767 ENOG41069ER domain protein CT43_CH0768 ENOG4107RBB ABC transporter, permease CT43_CH0769 ENOG4105C19 ABC transporter CT43_CH0775 ENOG4105WEF catalase CT43_CH0782 ENOG4107T5V SNARE associated Golgi CT43_CH0789 ENOG4105CUB amino acid CT43_CH0790 ENOG4107RWR Sodium hydrogen exchanger CT43_CH0792 ENOG4106KNT transcriptional regulator CT43_CH0800 ENOG4108YXU transcriptional regulator AsnC family CT43_CH0801 ENOG4105CH7 arginosuccinase CT43_CH0802 ENOG4105UBK short-chain dehydrogenase reductase CT43_CH0812 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CT43_CH0813 ENOG4105E5W Transporter CT43_CH0815 ENOG4107RKG DJ-1/PfpI family CT43_CH0816 ENOG4105CH6 catalase CT43_CH0818 ENOG4105D5Q Arginine ornithine antiporter CT43_CH0819 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CT43_CH0821 ENOG4105C26 Dehydrogenase CT43_CH0822 ENOG4105BZ1 (ABC) transporter CT43_CH0823 ENOG4105BZ1 (ABC) transporter CT43_CH0825 ENOG4105DRP amino acid AbC transporter CT43_CH0826 ENOG4105CDA abc transporter atp-binding protein CT43_CH0829 ENOG410839P CT43_CH0831 ENOG4108UH6 UPF0754 membrane protein CT43_CH0837 ENOG4107FQX Alpha-acetolactate decarboxylase CT43_CH0842 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CT43_CH0844 ENOG4105D4P Coproporphyrinogen iii oxidase CT43_CH0845 ENOG4105CEY Amp-dependent synthetase and ligase CT43_CH0848 ENOG4105CHH sulfate transporter CT43_CH0853 ENOG4105CGU Enoyl-CoA hydratase CT43_CH0857 ENOG4105DER m42 family CT43_CH0861 ENOG4105CTU Proline racemase CT43_CH0862 ENOG4105CIF Ornithine Cyclodeaminase CT43_CH0866 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CT43_CH0867 ENOG4105C3U ABC transporter CT43_CH0868 ENOG4108JQ7 (ABC) transporter CT43_CH0878 ENOG4105CSH Transporter CT43_CH0880 ENOG4108MRH transcriptional regulatory protein CT43_CH0882 ENOG4105M6F mutator MutT protein CT43_CH0885 ENOG4105CDU Replicative dna helicase CT43_CH0891 ENOG4105C0R drug resistance transporter emrb qaca subfamily CT43_CH0897 ENOG4105F6J Alpha beta hydrolase fold CT43_CH0905 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CT43_CH0908 ENOG4105F27 Major Facilitator CT43_CH0909 ENOG4105WAB arsR family transcriptional regulator CT43_CH0911 ENOG4105CMT Dihydroxyacetone kinase CT43_CH0913 ENOG4105CMT Dihydroxyacetone kinase CT43_CH0930 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CT43_CH0937 ENOG4105WN5 stage II sporulation protein CT43_CH0939 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH0941 ENOG4108MJI response regulator CT43_CH0942 ENOG4105BZU Histidine kinase CT43_CH0943 ENOG4105BZU Histidine kinase CT43_CH0949 ENOG4105DQ6 Transposase CT43_CH0952 ENOG4105EKQ RNA-directed DNA polymerase CT43_CH0954 ENOG4107QHE Choloylglycine hydrolase CT43_CH0958 ENOG4107VRP DNA repair exonuclease CT43_CH0959 ENOG4106D4I domain protein CT43_CH0962 ENOG410829K Lysine exporter protein (Lyse ygga) CT43_CH0968 ENOG4108MUZ hydrolase CT43_CH0973 ENOG4105F0F Oxalate decarboxylase CT43_CH0974 ENOG41067QW Transcriptional regulator CT43_CH0975 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CT43_CH0978 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CT43_CH0982 ENOG4105EMN RNA polymerase sigma factor CT43_CH0985 ENOG4105EEM helicase CT43_CH0987 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CT43_CH0991 ENOG4105K59 histidine triad (HIT) protein CT43_CH1006 ENOG410905X membrane-flanked domain protein CT43_CH1007 ENOG4105CKV Membrane CT43_CH1017 ENOG410905X membrane-flanked domain protein CT43_CH1018 ENOG4105CKV Membrane CT43_CH1019 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CT43_CH1020 ENOG4105BZ4 penicillin-binding protein CT43_CH1022 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CT43_CH1023 ENOG4105C1Q protoporphyrinogen oxidase CT43_CH1028 ENOG4105NA0 Transcriptional regulator CT43_CH1031 ENOG4105ECB domain protein CT43_CH1034 ENOG4108MK9 spermidine N(1)-acetyltransferase CT43_CH1036 ENOG4106AXD CT43_CH1037 ENOG4108RQ5 Beta-lactamase domain-containing protein CT43_CH1038 ENOG4105DF9 Lipoate-protein, ligase CT43_CH1040 ENOG4105CEY Amp-dependent synthetase and ligase CT43_CH1042 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CT43_CH1043 ENOG4108I5D sulfate abc transporter CT43_CH1044 ENOG4105ECW sulfate abc transporter CT43_CH1045 ENOG4108IJ6 ABC transporter CT43_CH1046 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) CT43_CH1047 ENOG4107RN3 metallophosphoesterase CT43_CH1048 ENOG4107TVP HD domain protein CT43_CH1050 ENOG4108AEY RNA polymerase sigma factor CT43_CH1051 ENOG41086D8 Transcriptional regulator CT43_CH1052 ENOG41085W3 Transposase CT43_CH1054 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CT43_CH1059 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CT43_CH1060 ENOG4105C8Q Methyl-accepting chemotaxis CT43_CH1061 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) CT43_CH1063 ENOG4107QP3 malate synthase g CT43_CH1067 ENOG4105VEQ Cold shock protein CT43_CH1075 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CT43_CH1076 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CT43_CH1084 ENOG4105ERH Fumarylacetoacetate hydrolase CT43_CH1086 ENOG4105C8Y Acetylornithine aminotransferase CT43_CH1089 ENOG4105CAQ asparagine synthetase CT43_CH1090 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CT43_CH1091 ENOG4105CH6 catalase CT43_CH1092 ENOG4105BZU Histidine kinase CT43_CH1096 ENOG4105QNR S1 RNA binding domain protein CT43_CH1097 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CT43_CH1099 ENOG4107AYK membrAne CT43_CH1100 ENOG41073B9 CT43_CH1102 ENOG4108KP7 hydrolase CT43_CH1104 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CT43_CH1110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CT43_CH1111 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CT43_CH1114 ENOG4105C31 Tryptophanyl-tRNA synthetase CT43_CH1117 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CT43_CH1118 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CT43_CH1120 ENOG4108JQ7 (ABC) transporter CT43_CH1121 ENOG4105UQX Mate efflux family protein CT43_CH1125 ENOG4108ZCF integral membrane protein CT43_CH1127 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CT43_CH1129 ENOG4105DPN Oligoendopeptidase f CT43_CH1131 ENOG4108Z18 K06886 hemoglobin CT43_CH1132 ENOG4105MIX Adenylate cyclase CT43_CH1133 ENOG4106EFP UPF0738 protein CT43_CH1135 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CT43_CH1136 ENOG4105EMS pseudouridine synthase CT43_CH1141 ENOG4105K64 Glycosyl transferase, family 2 CT43_CH1150 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CT43_CH1151 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CT43_CH1153 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CT43_CH1168 ENOG4105CK7 Sodium proline symporter CT43_CH1170 ENOG4105CRQ synthase (Component I) CT43_CH1171 ENOG4105DDQ anthranilate synthase CT43_CH1173 ENOG4105DK0 Indole-3-glycerol phosphate synthase CT43_CH1174 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CT43_CH1175 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CT43_CH1182 ENOG4105T65 Membrane-associated protein CT43_CH1187 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CT43_CH1191 ENOG4105C7S Dehydrogenase CT43_CH1193 ENOG4105VZ8 Transcriptional regulator CT43_CH1207 ENOG4105DZ1 carboxypeptidase CT43_CH1208 ENOG4105VFR signal peptidase CT43_CH1215 ENOG4105C26 Dehydrogenase CT43_CH1216 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CT43_CH1217 ENOG4105F38 ABC transporter, permease CT43_CH1218 ENOG4105D38 putrescine abc transporter CT43_CH1219 ENOG4107RUE extracellular solute-binding protein family 1 CT43_CH1221 ENOG4105EYF MMPL domain protein CT43_CH1223 ENOG4108YBP pseudouridine synthase CT43_CH1225 ENOG4105K4I Scp-like extracellular CT43_CH1226 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CT43_CH1227 ENOG4105CQB FAD linked oxidase domain protein CT43_CH1230 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH1232 ENOG4105BZU Histidine kinase CT43_CH1233 ENOG4105JXH GntR family transcriptional regulator CT43_CH1237 ENOG4106A3R peptidase CT43_CH1239 ENOG4108QTI )-transporter CT43_CH1240 ENOG4107TS3 membrane protein, TerC CT43_CH1241 ENOG4105CZN Potassium uptake protein CT43_CH1242 ENOG410681C small acid-soluble spore protein CT43_CH1243 ENOG4108Z7G MaoC domain protein dehydratase CT43_CH1247 ENOG4105CHR reductase CT43_CH1253 ENOG4105C4Y ABC transporter CT43_CH1254 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CT43_CH1255 ENOG4107RCV ABC transporter, permease CT43_CH1259 ENOG4105E98 transcriptional regulator DeoR family CT43_CH1262 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CT43_CH1264 ENOG4105PXI polysaccharide deacetylase CT43_CH1266 ENOG4105BZU Histidine kinase CT43_CH1267 ENOG41090MY MarR family Transcriptional regulator CT43_CH1269 ENOG4106DF1 CT43_CH1271 ENOG4105BZU Histidine kinase CT43_CH1272 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CT43_CH1273 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CT43_CH1274 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CT43_CH1282 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CT43_CH1283 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CT43_CH1284 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CT43_CH1285 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CT43_CH1286 ENOG4105CZV ABC transporter CT43_CH1288 ENOG4105CJ1 ABC, transporter CT43_CH1296 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CT43_CH1297 ENOG4105EA8 2-Nitropropane dioxygenase CT43_CH1298 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CT43_CH1300 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CT43_CH1305 ENOG4105NQC Flavodoxin CT43_CH1313 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CT43_CH1319 ENOG4105CZN Potassium uptake protein CT43_CH1320 ENOG41063Y9 CT43_CH1321 ENOG4105KBJ sporulation protein ytfj CT43_CH1325 ENOG4105CM2 brancheD-chain amino acid aminotransferase CT43_CH1326 ENOG4105C7K acetolactate synthase CT43_CH1327 ENOG4108ZP8 Acetolactate synthase small subunit CT43_CH1328 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CT43_CH1331 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CT43_CH1335 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CT43_CH1336 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CT43_CH1337 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CT43_CH1342 ENOG4107RVV histidinol phosphate phosphatase, hisj family CT43_CH1345 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CT43_CH1346 ENOG4105E0M Sulfatase CT43_CH1348 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CT43_CH1352 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CT43_CH1353 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CT43_CH1355 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CT43_CH1356 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CT43_CH1357 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CT43_CH1358 ENOG4105C8J )-transporter CT43_CH1363 ENOG4105DFD Na H antiporter CT43_CH1368 ENOG4105ENE Histidine kinase CT43_CH1369 ENOG4105WH1 Two component transcriptional regulator luxr family CT43_CH1372 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CT43_CH1377 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CT43_CH1381 ENOG4105CJ3 phosphate transporter CT43_CH1382 ENOG4107GRR phosphate transport regulator CT43_CH1383 ENOG4105BZ4 penicillin-binding protein CT43_CH1386 ENOG4105BZU Histidine kinase CT43_CH1387 ENOG4105I3N Conserved Protein CT43_CH1390 ENOG4105BZU Histidine kinase CT43_CH1396 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CT43_CH1397 ENOG4105DZ1 carboxypeptidase CT43_CH1398 ENOG4108JIC nucleoside recognition domain protein CT43_CH1400 ENOG4105FE9 pseudouridine synthase CT43_CH1401 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CT43_CH1402 ENOG4107TWT Cytochrome c biogenesis protein CT43_CH1403 ENOG4105CRE cytochrome C CT43_CH1404 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH1405 ENOG4105BZU Histidine kinase CT43_CH1406 ENOG4108WBT adenosyltransferase CT43_CH1409 ENOG4108SAX Membrane CT43_CH1412 ENOG4105C9U ATP-dependent DNA helicase RecQ CT43_CH1413 ENOG4105I7S Abortive infection protein CT43_CH1415 ENOG4107RGJ metallophosphoesterase CT43_CH1416 ENOG4108XDN Transcriptional regulator CT43_CH1417 ENOG4108S6Z Negative regulator of genetic competence CT43_CH1422 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CT43_CH1423 ENOG4107RB3 L-asparaginase CT43_CH1429 ENOG4105S2F CT43_CH1430 ENOG41065D1 CT43_CH1436 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CT43_CH1439 ENOG4105XXQ heptaprenyl diphosphate synthase component I CT43_CH1441 ENOG4105EAH synthase CT43_CH1442 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CT43_CH1443 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CT43_CH1446 ENOG41068YB TPR repeat-containing protein CT43_CH1449 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CT43_CH1450 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CT43_CH1457 ENOG4108JYZ YitT family CT43_CH1458 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CT43_CH1461 ENOG4105FJR Lmbe family CT43_CH1462 ENOG4105CPK Glycosyl transferase (Group 1 CT43_CH1466 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CT43_CH1469 ENOG4105DVT helicase CT43_CH1470 ENOG4105YAC CT43_CH1474 ENOG4105CSM endonuclease III CT43_CH1476 ENOG4105BZ4 penicillin-binding protein CT43_CH1485 ENOG4106F55 Protein of unknown function (DUF1273) CT43_CH1487 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CT43_CH1490 ENOG4105CTD carboxy-peptidase CT43_CH1492 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CT43_CH1493 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CT43_CH1494 ENOG4105C2W permease CT43_CH1495 ENOG4105DHF Membrane CT43_CH1497 ENOG410890F Dynamin family CT43_CH1499 ENOG4108W0I acetyltransferase CT43_CH1501 ENOG4105KHC sulfurtransferase CT43_CH1510 ENOG4105HTX biosynthesis protein CT43_CH1516 ENOG4105CPK Glycosyl transferase (Group 1 CT43_CH1519 ENOG4108SZE gCN5-related N-acetyltransferase CT43_CH1523 ENOG41081VK Ribonuclease CT43_CH1536 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CT43_CH1538 ENOG4107RWR Sodium hydrogen exchanger CT43_CH1539 ENOG4108Z5V transcriptional regulator, merr family CT43_CH1541 ENOG4105H67 Protein of unknown function (DUF421) CT43_CH1542 ENOG41080C8 DUF218 domain CT43_CH1554 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CT43_CH1556 ENOG4105DD5 Flagellar motor switch protein CT43_CH1559 ENOG4105BZU Histidine kinase CT43_CH1563 ENOG4105E1Q flagellar hook-associated protein CT43_CH1564 ENOG4105DTJ flagellar hook-associated protein CT43_CH1568 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CT43_CH1569 ENOG4108ZC9 flagellar basal-body rod protein flgc CT43_CH1570 ENOG41075Z6 flagellar hook-basal body complex protein fliE CT43_CH1571 ENOG4107U2N Flagellar M-ring protein CT43_CH1572 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CT43_CH1578 ENOG4105BZE flagellar hook protein, FlgE CT43_CH1581 ENOG4107R88 Chemotaxis protein (CheV) CT43_CH1583 ENOG4105I03 Flagellin CT43_CH1584 ENOG4105I03 Flagellin CT43_CH1585 ENOG4105E4C Lytic transglycosylase catalytic CT43_CH1587 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CT43_CH1588 ENOG4105DD5 Flagellar motor switch protein CT43_CH1590 ENOG4105CN7 Flagellar biosynthetic protein FliP CT43_CH1591 ENOG4105VS8 Flagellar biosynthetic protein fliq CT43_CH1593 ENOG4105D00 flagellar biosynthetic protein flhB CT43_CH1594 ENOG4105D7B Flagellar biosynthesis protein flha CT43_CH1595 ENOG4105FZW flagellar biosynthesis regulator FlhF CT43_CH1596 ENOG4105KTQ flagellar basal-body rod protein CT43_CH1597 ENOG4105CPU Monooxygenase CT43_CH1598 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CT43_CH1604 ENOG4105KAC Antibiotic biosynthesis monooxygenase CT43_CH1605 ENOG4107QZ7 Cellulose synthase catalytic subunit CT43_CH1610 ENOG4105DUM transcriptional regulator, lysR family CT43_CH1611 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CT43_CH1613 ENOG4105D38 putrescine abc transporter CT43_CH1622 ENOG4105CVJ phosphoglycerate mutase CT43_CH1624 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CT43_CH1628 ENOG4105CAQ asparagine synthetase CT43_CH1632 ENOG4105PGM cation diffusion facilitator family transporter CT43_CH1634 ENOG4105DRR Transcriptional regulator, GntR family CT43_CH1635 ENOG4108UZ3 Transporter CT43_CH1637 ENOG4105CKI cobalamin synthesis protein CT43_CH1638 ENOG4108PJD permease CT43_CH1642 ENOG4105DFD Na H antiporter CT43_CH1643 ENOG4105VUF Transcriptional regulator CT43_CH1645 ENOG4105C9Q fumarate hydratase class II CT43_CH1649 ENOG4107QJQ Mate efflux family protein CT43_CH1650 ENOG4105EC3 peptidase S51, dipeptidase E CT43_CH1654 ENOG4107QIV Cytochrome c biogenesis protein CT43_CH1655 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CT43_CH1658 ENOG4107JM4 Tetratricopeptide repeat CT43_CH1661 ENOG4105BZC d-serine deaminase CT43_CH1662 ENOG4106BRA Membrane CT43_CH1669 ENOG4105CJ1 ABC, transporter CT43_CH1673 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CT43_CH1675 ENOG4108IJ0 Aspartate ammonia-lyase CT43_CH1676 ENOG4105C6K Malic enzyme CT43_CH1687 ENOG4105FVX CT43_CH1690 ENOG4105CSR polyphosphate kinase 2 CT43_CH1691 ENOG4105U3E Transcriptional regulator CT43_CH1693 ENOG4105DXI Major Facilitator superfamily CT43_CH1696 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CT43_CH1697 ENOG4105EU0 Major facilitator Superfamily CT43_CH1698 ENOG4105C6T cysteine synthase CT43_CH1702 ENOG4105C8J )-transporter CT43_CH1704 ENOG4105X5K response regulator receiver protein CT43_CH1705 ENOG4105H67 Protein of unknown function (DUF421) CT43_CH1709 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CT43_CH1710 ENOG4105CHR reductase CT43_CH1711 ENOG4105CM2 brancheD-chain amino acid aminotransferase CT43_CH1712 ENOG4105C7K acetolactate synthase CT43_CH1714 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CT43_CH1716 ENOG4105C7B Threonine dehydratase CT43_CH1720 ENOG4105C6X Major Facilitator CT43_CH1721 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CT43_CH1723 ENOG4105DY9 regulatoR CT43_CH1724 ENOG4105CYC Transferase CT43_CH1728 ENOG4105EQ0 Major Facilitator superfamily CT43_CH1729 ENOG4108IND Tetr family transcriptional regulator CT43_CH1731 ENOG41068WN CT43_CH1736 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CT43_CH1739 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CT43_CH1741 ENOG4105C0X amino acid CT43_CH1751 ENOG410849A acetyltransferase, (GNAT) family CT43_CH1755 ENOG4107RHR regulatoR CT43_CH1757 ENOG4105D9N nucleoside CT43_CH1758 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CT43_CH1764 ENOG410811B TRANSCRIPTIONal CT43_CH1767 ENOG4107RAQ aminopeptidase CT43_CH1769 ENOG4107R16 Multicopper oxidase CT43_CH1777 ENOG4108T5E Copper resistance protein CT43_CH1778 ENOG4105KTB nuclear export factor GLE1 CT43_CH1780 ENOG4107RT3 EamA-like transporter family CT43_CH1781 ENOG4105GZI Transcriptional regulator CT43_CH1782 ENOG4108Z40 Transcriptional regulator CT43_CH1783 ENOG4107ZXU DSBA oxidoreductase CT43_CH1784 ENOG4108TVJ Nitroreductase CT43_CH1786 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CT43_CH1793 ENOG41085W3 Transposase CT43_CH1808 ENOG4105C2M dna polymerase I CT43_CH1827 ENOG4105KRN Transcriptional regulator, abrb family CT43_CH1854 ENOG4105XSJ toxin secretion phage lysis holin CT43_CH1870 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CT43_CH1872 ENOG4106F5Q Membrane CT43_CH1874 ENOG4106F5Q Membrane CT43_CH1875 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CT43_CH1878 ENOG4105CKI cobalamin synthesis protein CT43_CH1880 ENOG4105C0Z ABC transporter CT43_CH1881 ENOG4108IV0 ABC, transporter CT43_CH1882 ENOG4105C32 Amino acid ABC transporter (Permease) CT43_CH1884 ENOG4105EGI Transcriptional regulator CT43_CH1886 ENOG4105MDS 4-oxalocrotonate tautomerase CT43_CH1890 ENOG4105C4M (Ubiquinol oxidase) subunit I CT43_CH1891 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CT43_CH1892 ENOG4108JJ9 ABC, transporter CT43_CH1893 ENOG4108JJ8 (ABC) transporter CT43_CH1895 ENOG4105K64 Glycosyl transferase, family 2 CT43_CH1897 ENOG4108UT6 Transferase hexapeptide repeat containing protein CT43_CH1909 ENOG4105BZ1 (ABC) transporter CT43_CH1910 ENOG4105EFI regulatoR CT43_CH1911 ENOG4105BZU Histidine kinase CT43_CH1915 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CT43_CH1916 ENOG4108ZJ4 polysaccharide deacetylase CT43_CH1921 ENOG4105D6E homoserine dehydrogenase CT43_CH1923 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CT43_CH1926 ENOG4108KGH TRANSCRIPTIONal CT43_CH1928 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CT43_CH1929 ENOG4105BZU Histidine kinase CT43_CH1930 ENOG4107VMI polysaccharide deacetylase CT43_CH1932 ENOG4105KT7 mgtC SapB transporter CT43_CH1933 ENOG4105VRR gCN5-related N-acetyltransferase CT43_CH1935 ENOG4105DUU IucA IucC family protein CT43_CH1936 ENOG4105CEY Amp-dependent synthetase and ligase CT43_CH1939 ENOG4108WBH protein TIM barrel CT43_CH1940 ENOG4105YWU small acid-soluble spore protein CT43_CH1942 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CT43_CH1943 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CT43_CH1953 ENOG4105KRN Transcriptional regulator, abrb family CT43_CH1955 ENOG4105YVS arsR family transcriptional regulator CT43_CH1956 ENOG4105CPC Aldo Keto reductase CT43_CH1957 ENOG4107XZQ multidrug resistance protein CT43_CH1962 ENOG4105C8Q Methyl-accepting chemotaxis CT43_CH1965 ENOG4108K88 Membrane CT43_CH1966 ENOG4108WPJ Ferritin-like domain CT43_CH1969 ENOG4105DEN Luciferase family CT43_CH1972 ENOG4105VMI -acetyltransferase CT43_CH1973 ENOG4107QM2 Aldo Keto reductase CT43_CH1974 ENOG4105CKI cobalamin synthesis protein CT43_CH1976 ENOG4105DSE periplasmic solute binding protein CT43_CH1978 ENOG4105K4T epimerase CT43_CH1989 ENOG4107T5V SNARE associated Golgi CT43_CH1992 ENOG4108PJD permease CT43_CH1994 ENOG4108S4H thioesterase Superfamily protein CT43_CH1995 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CT43_CH1999 ENOG4105SXS Protein of unknown function (DUF456) CT43_CH2000 ENOG4105C37 (CBS) domain CT43_CH2006 ENOG4108Z7R Chaperone CsaA CT43_CH2009 ENOG4108ZRV stage ii sporulation protein p CT43_CH2011 ENOG4108VXD carboxy-peptidase CT43_CH2017 ENOG4108ZRV stage ii sporulation protein p CT43_CH2019 ENOG4108X4Q Hydrolase CT43_CH2020 ENOG41082F9 transcriptional regulator CT43_CH2021 ENOG4105D94 Major Facilitator Superfamily CT43_CH2023 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CT43_CH2024 ENOG4107RBS Methyltransferase CT43_CH2027 ENOG41087PP glycosyltransferase MGT family CT43_CH2028 ENOG4108JYZ YitT family CT43_CH2029 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CT43_CH2035 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CT43_CH2045 ENOG4105KBJ sporulation protein ytfj CT43_CH2050 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CT43_CH2054 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CT43_CH2055 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CT43_CH2057 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CT43_CH2058 ENOG4105EMN RNA polymerase sigma factor CT43_CH2061 ENOG4105CNW domain protein CT43_CH2063 ENOG4108V06 Glutathione peroxidase CT43_CH2066 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CT43_CH2068 ENOG4108IUE nitrate reductase beta subunit CT43_CH2069 ENOG4105R3A Nitrate reductase CT43_CH2071 ENOG4107V6Q Cyclic nucleotide-binding domain CT43_CH2072 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CT43_CH2073 ENOG4105D06 uba thif-type nad fad binding protein CT43_CH2074 ENOG4105CVM Molybdenum cofactor synthesis domain protein CT43_CH2075 ENOG4108ZAF Molybdopterin CT43_CH2080 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CT43_CH2081 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CT43_CH2082 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CT43_CH2083 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CT43_CH2084 ENOG4108IFG nitrite reductase, (NAD(P)H) CT43_CH2085 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CT43_CH2092 ENOG4105MCT stage V sporulation protein S CT43_CH2094 ENOG4108IBT Inherit from COG: transposase CT43_CH2098 ENOG4105C5H ABC transporter CT43_CH2101 ENOG4108UUM single-stranded DNA-binding protein CT43_CH2107 ENOG4107YX5 Pfam:DUF548 CT43_CH2108 ENOG4105C75 arginyL-tRNA synthetase CT43_CH2111 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CT43_CH2116 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CT43_CH2117 ENOG4105C5S asparaginyl-tRNA synthetase CT43_CH2121 ENOG4105EC2 ftsk spoIIIe CT43_CH2135 ENOG4105C8J )-transporter CT43_CH2139 ENOG4107XGZ Hydrolase CT43_CH2140 ENOG4105CY2 Citrate transporter CT43_CH2144 ENOG4105KD7 acetyltransferase CT43_CH2146 ENOG4105VMP Transcriptional regulator CT43_CH2147 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CT43_CH2152 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 CT43_CH2155 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CT43_CH2158 ENOG4107RVG penicillin-binding protein CT43_CH2160 ENOG4105E9Q Acyl-transferase CT43_CH2161 ENOG4108UT2 hemolysin iii CT43_CH2163 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CT43_CH2165 ENOG4108RCR degv family CT43_CH2167 ENOG4108KF3 Electron transport protein SCO1 SenC CT43_CH2168 ENOG4107Y70 Heat shock protein CT43_CH2169 ENOG4105CAQ asparagine synthetase CT43_CH2172 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CT43_CH2173 ENOG4108MES Periplasmic binding protein CT43_CH2174 ENOG4105F0I Aminotransferase CT43_CH2179 ENOG4105D8X mechanosensitive ion channel CT43_CH2180 ENOG4105BZU Histidine kinase CT43_CH2181 ENOG4105WH1 Two component transcriptional regulator luxr family CT43_CH2182 ENOG4106KNT transcriptional regulator CT43_CH2183 ENOG4107ZY0 Phenazine biosynthesis-like protein CT43_CH2189 ENOG4105CMG Carbohydrate kinase CT43_CH2190 ENOG4105C6Z Gluconate CT43_CH2192 ENOG4108YV3 Protein of unknown function (DUF2711) CT43_CH2198 ENOG4108IJ8 ABC transporter CT43_CH2199 ENOG4105E90 ABC transporter CT43_CH2206 ENOG4105C37 (CBS) domain CT43_CH2211 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CT43_CH2214 ENOG4107S4Y M20 DapE family protein YgeY CT43_CH2215 ENOG4108TSC N-acetyltransferase CT43_CH2216 ENOG4108JUB Transcriptional regulator CT43_CH2217 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CT43_CH2226 ENOG410841Q phosphoesterase PA-phosphatase related protein CT43_CH2228 ENOG4105SZ6 Thioredoxin CT43_CH2229 ENOG4105KNA -acetyltransferase CT43_CH2235 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CT43_CH2245 ENOG4105BZ4 penicillin-binding protein CT43_CH2246 ENOG4105CZM Major Facilitator CT43_CH2247 ENOG4105W8X HesB YadR YfhF-family protein CT43_CH2249 ENOG4105DXD 2-methylcitrate dehydratase CT43_CH2250 ENOG4105CR4 methylisocitrate lyase CT43_CH2251 ENOG4105C1G acyl-Coa dehydrogenase CT43_CH2252 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CT43_CH2254 ENOG4105N14 lysine exporter protein LysE YggA CT43_CH2255 ENOG4105E39 Enoyl-CoA hydratase CT43_CH2258 ENOG4107RFY SbcCD D subunit CT43_CH2259 ENOG4105EYH Exonuclease CT43_CH2264 ENOG4105FCD Major Facilitator CT43_CH2265 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CT43_CH2266 ENOG4105E4F Isochorismate synthase CT43_CH2267 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CT43_CH2268 ENOG4105WQI isochorismatase CT43_CH2269 ENOG4105CEY Amp-dependent synthetase and ligase CT43_CH2270 ENOG4105WQT MbtH domain protein CT43_CH2271 ENOG4105C0R drug resistance transporter emrb qaca subfamily CT43_CH2274 ENOG4105K70 DNA-binding protein CT43_CH2278 ENOG4105BZG amino acid carrier protein CT43_CH2282 ENOG4105FE9 pseudouridine synthase CT43_CH2283 ENOG4105C22 threonyL-tRNA synthetase CT43_CH2284 ENOG4105C19 ABC transporter CT43_CH2294 ENOG41081I9 integral membrane protein CT43_CH2296 ENOG4108Y4K DNA-binding transcriptional activator CT43_CH2300 ENOG4107MII Sugar-specific transcriptional regulator TrmB CT43_CH2302 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CT43_CH2304 ENOG4105EYF MMPL domain protein CT43_CH2309 ENOG4105WCN acetyltransferase CT43_CH2314 ENOG4105C1Q protoporphyrinogen oxidase CT43_CH2316 ENOG41068WN CT43_CH2322 ENOG4107V2S Transcriptional regulator CT43_CH2323 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CT43_CH2327 ENOG4105DND Transcriptional regulator CT43_CH2328 ENOG4108RPX mosc domain containing protein CT43_CH2331 ENOG4105BZ1 (ABC) transporter CT43_CH2332 ENOG4105BZ1 (ABC) transporter CT43_CH2351 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CT43_CH2353 ENOG4108IBT Inherit from COG: transposase CT43_CH2356 ENOG4108JCI Transcriptional regulator CT43_CH2362 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CT43_CH2363 ENOG4108KPJ rna polymerase sigma factor CT43_CH2368 ENOG4105F32 YngK protein CT43_CH2372 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CT43_CH2373 ENOG4105RD7 BadF BadG BcrA BcrD CT43_CH2374 ENOG4105R9Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CT43_CH2376 ENOG4105C7B Threonine dehydratase CT43_CH2377 ENOG4108INS Transcriptional regulator CT43_CH2380 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CT43_CH2382 ENOG4105C1J atp-dependent rna helicase CT43_CH2388 ENOG41088CC tellurite resistance protein tehB CT43_CH2390 ENOG4108I0C methyltransferase CT43_CH2391 ENOG4107RA9 decarboxylase CT43_CH2392 ENOG4105K56 Transcriptional regulator CT43_CH2393 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CT43_CH2399 ENOG4105CIN aminoacyl-histidine dipeptidase CT43_CH2405 ENOG4105KRN Transcriptional regulator, abrb family CT43_CH2407 ENOG4105EJ9 Membrane CT43_CH2408 ENOG4105EQK -acetyltransferase CT43_CH2416 ENOG4105W8Z 4'-phosphopantetheinyl transferase CT43_CH2421 ENOG4105CSV Glutaminase CT43_CH2426 ENOG4108Q8B Spore germination protein CT43_CH2427 ENOG4108NHD germination protein CT43_CH2428 ENOG4105II7 pyrroline-5-carboxylate reductase CT43_CH2429 ENOG4105CUB amino acid CT43_CH2430 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CT43_CH2432 ENOG41075H3 AraC family transcriptional regulator CT43_CH2437 ENOG4105BZU Histidine kinase CT43_CH2439 ENOG4107S9D Alpha beta hydrolase CT43_CH2451 ENOG41085W3 Transposase CT43_CH2453 ENOG4107RVG penicillin-binding protein CT43_CH2456 ENOG4105CJN penicillin-binding protein CT43_CH2457 ENOG4107RF6 penicillin-binding protein CT43_CH2460 ENOG4105DIN metallophosphoesterase CT43_CH2462 ENOG4105CJ1 ABC, transporter CT43_CH2464 ENOG4107Z3H Transcriptional regulator, TetR family CT43_CH2467 ENOG4105C1G acyl-Coa dehydrogenase CT43_CH2468 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CT43_CH2469 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CT43_CH2470 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CT43_CH2471 ENOG4105E39 Enoyl-CoA hydratase CT43_CH2472 ENOG4107QX3 carboxylase CT43_CH2473 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CT43_CH2476 ENOG41085W3 Transposase CT43_CH2482 ENOG4105DZ1 carboxypeptidase CT43_CH2485 ENOG4105T9C HD domain CT43_CH2487 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CT43_CH2491 ENOG41075H3 AraC family transcriptional regulator CT43_CH2497 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CT43_CH2499 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CT43_CH2503 ENOG4105KVH Transcriptional regulator CT43_CH2513 ENOG4105EFA 4-hydroxyphenylacetate CT43_CH2516 ENOG4105CPQ Dehydrogenase CT43_CH2518 ENOG410900G Protein of unknown function (DUF421) CT43_CH2520 ENOG4108V4B ThiJ pfpI CT43_CH2522 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CT43_CH2524 ENOG4105DK7 lysyl-tRNA synthetase CT43_CH2538 ENOG4105D6E homoserine dehydrogenase CT43_CH2540 ENOG4105CPF Cell wall formation (By similarity) CT43_CH2541 ENOG4105ETU transcriptional activator (TenA CT43_CH2547 ENOG4105VTR Integrase CT43_CH2562 ENOG4105KRN Transcriptional regulator, abrb family CT43_CH2585 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CT43_CH2597 ENOG41085W3 Transposase CT43_CH2599 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CT43_CH2617 ENOG410667J hydrolase CT43_CH2618 ENOG4105BZU Histidine kinase CT43_CH2619 ENOG4107RF6 penicillin-binding protein CT43_CH2624 ENOG4108JJB ABC transporter CT43_CH2627 ENOG4108HGU Histidine kinase CT43_CH2639 ENOG4105CB2 alcohol dehydrogenase CT43_CH2640 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CT43_CH2641 ENOG4105CJN penicillin-binding protein CT43_CH2656 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CT43_CH2661 ENOG4107Y9U Membrane CT43_CH2670 ENOG4105FCD Major Facilitator CT43_CH2672 ENOG4105E09 nadh pyrophosphatase CT43_CH2673 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CT43_CH2679 ENOG4108XI2 Domain of unknown function (DUF1963) CT43_CH2683 ENOG4108NRW Phospholipase, patatin family CT43_CH2684 ENOG4105KWG Pfam:DUF1696 CT43_CH2691 ENOG4105PKS Excinuclease abc c subunit domain protein CT43_CH2699 ENOG4107VFR oxidoreductase CT43_CH2705 ENOG4105U0R haloacid dehalogenase-like hydrolase CT43_CH2706 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH2707 ENOG4105BZU Histidine kinase CT43_CH2713 ENOG4107WD8 ABC transporter, permease CT43_CH2716 ENOG4105DY8 decarboxylase CT43_CH2719 ENOG4108IUM Glycogen debranching enzyme CT43_CH2721 ENOG4105CGH 5'-nucleotidase CT43_CH2725 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CT43_CH2727 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) CT43_CH2728 ENOG4105FDR Membrane CT43_CH2730 ENOG4105CIS alcohol dehydrogenase CT43_CH2731 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CT43_CH2746 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) CT43_CH2747 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) CT43_CH2748 ENOG4107Z3H Transcriptional regulator, TetR family CT43_CH2749 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CT43_CH2753 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CT43_CH2757 ENOG4105E98 transcriptional regulator DeoR family CT43_CH2760 ENOG41062ES Transcriptional regulator CT43_CH2764 ENOG4107QKR Dehydrogenase CT43_CH2766 ENOG4107RUY (E1 component), alpha subunit CT43_CH2769 ENOG4105E1F short-chain dehydrogenase reductase CT43_CH2770 ENOG4105RHY Pfam:UPF0157 CT43_CH2778 ENOG4107SQ8 Glycine betaine CT43_CH2779 ENOG4108IJ7 Glycine betaine CT43_CH2784 ENOG4105E66 phosphoriboisomerase A CT43_CH2785 ENOG41082BV acetyltransferase CT43_CH2786 ENOG4108M1A Chitin-binding protein CT43_CH2787 ENOG41087PP glycosyltransferase MGT family CT43_CH2792 ENOG4105MSB protein, conserved in bacteria CT43_CH2797 ENOG4108Z7F N-acetyltransferase CT43_CH2803 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CT43_CH2804 ENOG4105EEM helicase CT43_CH2806 ENOG4105DQ6 Transposase CT43_CH2811 ENOG4105C9U ATP-dependent DNA helicase RecQ CT43_CH2820 ENOG4108M1A Chitin-binding protein CT43_CH2824 ENOG4105BZG amino acid carrier protein CT43_CH2825 ENOG4105C26 Dehydrogenase CT43_CH2826 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CT43_CH2827 ENOG4105CTU Proline racemase CT43_CH2828 ENOG4105CTU Proline racemase CT43_CH2829 ENOG41080HI glycine oxidase CT43_CH2831 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CT43_CH2838 ENOG4105DCI Phosphohydrolase CT43_CH2839 ENOG4107T5V SNARE associated Golgi CT43_CH2841 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CT43_CH2845 ENOG4105DTQ mandelate racemase muconate lactonizing CT43_CH2848 ENOG4107SET aldo keto reductase CT43_CH2854 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CT43_CH2855 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CT43_CH2856 ENOG4105BZU Histidine kinase CT43_CH2857 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH2860 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 CT43_CH2864 ENOG4105DPN Oligoendopeptidase f CT43_CH2865 ENOG4105EPR degv family CT43_CH2874 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CT43_CH2875 ENOG4106K7D Major facilitator family transporter CT43_CH2881 ENOG4107BMA Transglycosylase associated protein CT43_CH2884 ENOG41089UC methyltransferase, type 11 CT43_CH2892 ENOG4105CHM Aminotransferase CT43_CH2895 ENOG4108ZMI UPF0477 protein CT43_CH2898 ENOG4105DVE abc transporter atp-binding protein CT43_CH2906 ENOG4105C02 permease CT43_CH2908 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CT43_CH2909 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CT43_CH2910 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CT43_CH2911 ENOG4105D7T ABC transporter CT43_CH2918 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CT43_CH2926 ENOG4107VC0 DNA alkylation repair enzyme CT43_CH2928 ENOG4105C6T cysteine synthase CT43_CH2929 ENOG4105C6T cysteine synthase CT43_CH2930 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CT43_CH2933 ENOG4107VMI polysaccharide deacetylase CT43_CH2935 ENOG4108ZCF integral membrane protein CT43_CH2936 ENOG4105E0M Sulfatase CT43_CH2937 ENOG4105C5H ABC transporter CT43_CH2938 ENOG4105EYF MMPL domain protein CT43_CH2939 ENOG41082JN Transcriptional regulator CT43_CH2944 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CT43_CH2945 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CT43_CH2954 ENOG41069ER domain protein CT43_CH2956 ENOG4105DNP FAD linked oxidase domain protein CT43_CH2961 ENOG4105D4B ABC, transporter CT43_CH2962 ENOG4105F5R ABC transporter CT43_CH2963 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CT43_CH2965 ENOG4105DKT Transcriptional regulator CT43_CH2966 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) CT43_CH2968 ENOG41061GT Aldolase CT43_CH2970 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CT43_CH2972 ENOG4105YVS arsR family transcriptional regulator CT43_CH2976 ENOG4105II7 pyrroline-5-carboxylate reductase CT43_CH2978 ENOG4107258 Transcriptional regulator CT43_CH2983 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CT43_CH2985 ENOG4105ECK Fatty Acid Desaturase CT43_CH2987 ENOG4107RBI VanW family CT43_CH2988 ENOG4105G6Z alkaline phosphatase CT43_CH2990 ENOG4105VMP Transcriptional regulator CT43_CH2994 ENOG41068WN CT43_CH3001 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CT43_CH3005 ENOG4105C8Y Acetylornithine aminotransferase CT43_CH3013 ENOG4108TVJ Nitroreductase CT43_CH3014 ENOG4105FS7 Transcriptional regulator CT43_CH3018 ENOG4105WEC Molybdate metabolism regulator CT43_CH3019 ENOG4105CMR udp-glucose 4-epimerase CT43_CH3024 ENOG4108DMH HTH_ARAC CT43_CH3025 ENOG4108XET gCN5-related N-acetyltransferase CT43_CH3029 ENOG4108PCN EamA-like transporter family CT43_CH3039 ENOG410635A Membrane CT43_CH3041 ENOG4108IQI permease CT43_CH3043 ENOG4105F1N DNA alkylation repair CT43_CH3045 ENOG4105BZU Histidine kinase CT43_CH3046 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH3048 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CT43_CH3054 ENOG4107RF6 penicillin-binding protein CT43_CH3055 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CT43_CH3056 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CT43_CH3059 ENOG4105E7W lamb ycsf family protein CT43_CH3061 ENOG4105P4J Allophanate hydrolase, subunit 1 CT43_CH3062 ENOG4107258 Transcriptional regulator CT43_CH3065 ENOG4106N3A copper homeostasis protein cutc CT43_CH3066 ENOG4108ZHR arsR family transcriptional regulator CT43_CH3068 ENOG4105FDT acyl-CoA dehydrogenase CT43_CH3072 ENOG4105DWD nucleoside recognition domain protein CT43_CH3083 ENOG4105CGH 5'-nucleotidase CT43_CH3085 ENOG4105CHJ isochorismatase hydrolase CT43_CH3090 ENOG41090MY MarR family Transcriptional regulator CT43_CH3103 ENOG4108606 TspO/MBR family CT43_CH3104 ENOG4105CVP deoxyribo-dipyrimidine photolyase CT43_CH3107 ENOG4108TWJ NADH dehydrogenase subunit 5 CT43_CH3108 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CT43_CH3109 ENOG4107VMI polysaccharide deacetylase CT43_CH3110 ENOG4105KY5 gCN5-related N-acetyltransferase CT43_CH3111 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CT43_CH3113 ENOG4105D6J arsenicaL-resistance protein CT43_CH3114 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CT43_CH3115 ENOG41085FC arsR family transcriptional regulator CT43_CH3117 ENOG4105NAE bifunctional deaminase-reductase domain protein CT43_CH3118 ENOG4107P5I polyketide synthase CT43_CH3119 ENOG4108IG5 Transcriptional regulator CT43_CH3128 ENOG4105F27 Major Facilitator CT43_CH3129 ENOG4105M4P Tetr family transcriptional regulator CT43_CH3130 ENOG4105CHR reductase CT43_CH3131 ENOG4108YXU transcriptional regulator AsnC family CT43_CH3140 ENOG4105N0V mono-oxygenase ydhR CT43_CH3145 ENOG41085W3 Transposase CT43_CH3148 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH3149 ENOG41062D9 Histidine kinase CT43_CH3157 ENOG4105C19 ABC transporter CT43_CH3164 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CT43_CH3165 ENOG4105C0R drug resistance transporter emrb qaca subfamily CT43_CH3170 ENOG4105K6H D-cysteine desulfhydrase CT43_CH3175 ENOG4105E0Y RtcB Protein CT43_CH3177 ENOG4105JQZ Methyltransferase CT43_CH3180 ENOG4105DNP FAD linked oxidase domain protein CT43_CH3182 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CT43_CH3186 ENOG4105BZU Histidine kinase CT43_CH3188 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CT43_CH3191 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CT43_CH3195 ENOG4108JQ1 Dehydrogenase CT43_CH3196 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CT43_CH3199 ENOG41082W1 Cupin 2, conserved barrel domain protein CT43_CH3200 ENOG410874W AraC family transcriptional regulator CT43_CH3204 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CT43_CH3208 ENOG4108VXD carboxy-peptidase CT43_CH3209 ENOG4105PNM synthesis protein CT43_CH3211 ENOG4108ISG Major Facilitator CT43_CH3214 ENOG4107MII Sugar-specific transcriptional regulator TrmB CT43_CH3215 ENOG4105CZM Major Facilitator CT43_CH3220 ENOG4105CRW Short chain fatty acid transporter CT43_CH3222 ENOG4105DYS nad(p)h dehydrogenase (quinone) CT43_CH3234 ENOG4108K8S endonuclease I CT43_CH3236 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CT43_CH3238 ENOG41067QW Transcriptional regulator CT43_CH3240 ENOG4108Z66 YbaK ebsC protein CT43_CH3241 ENOG4105CUT histidyl-tRNA synthetase CT43_CH3244 ENOG4105KVH Transcriptional regulator CT43_CH3245 ENOG4108RCM Nitroreductase CT43_CH3251 ENOG4108PSK reductase CT43_CH3265 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CT43_CH3266 ENOG4105DKQ ROK family CT43_CH3268 ENOG4108UW5 maltose o-acetyltransferase CT43_CH3269 ENOG4105C31 Tryptophanyl-tRNA synthetase CT43_CH3270 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CT43_CH3278 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) CT43_CH3280 ENOG4105EV4 Multidrug resistance protein mdtH CT43_CH3285 ENOG4105C37 (CBS) domain CT43_CH3288 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CT43_CH3289 ENOG4105FAW cDP-glucose 4,6-dehydratase CT43_CH3296 ENOG4105DDN Pentapeptide repeat-containing protein CT43_CH3297 ENOG4105XDF Protein of unknown function (DUF1272) CT43_CH3298 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CT43_CH3299 ENOG4105CMG Carbohydrate kinase CT43_CH3300 ENOG4105CMG Carbohydrate kinase CT43_CH3301 ENOG4105C6Z Gluconate CT43_CH3304 ENOG4105CV1 Transketolase (EC 2.2.1.1) CT43_CH3305 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CT43_CH3306 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CT43_CH3307 ENOG4105CIS alcohol dehydrogenase CT43_CH3308 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CT43_CH3310 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CT43_CH3313 ENOG4105C8Q Methyl-accepting chemotaxis CT43_CH3314 ENOG4108UX3 '-nucleotidase CT43_CH3315 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CT43_CH3316 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CT43_CH3317 ENOG4105KVH Transcriptional regulator CT43_CH3320 ENOG4105CV8 reductase CT43_CH3321 ENOG4105F27 Major Facilitator CT43_CH3323 ENOG41090KN UPF0303 protein CT43_CH3325 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CT43_CH3326 ENOG4105CHH sulfate transporter CT43_CH3329 ENOG4105C44 Serine transporter CT43_CH3336 ENOG4105KVH Transcriptional regulator CT43_CH3337 ENOG4108TZY GntR Family Transcriptional Regulator CT43_CH3339 ENOG4105D9R oxidoreductase CT43_CH3340 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CT43_CH3341 ENOG4105KVH Transcriptional regulator CT43_CH3342 ENOG4105KVH Transcriptional regulator CT43_CH3352 ENOG4105JAB phenazine biosynthesis protein, phzf family CT43_CH3354 ENOG4105CHR reductase CT43_CH3357 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CT43_CH3358 ENOG4105KVH Transcriptional regulator CT43_CH3361 ENOG4108ZJ4 polysaccharide deacetylase CT43_CH3375 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) CT43_CH3377 ENOG4107YXZ hydrolase, family 25 CT43_CH3383 ENOG4105H3G oxidoreductase CT43_CH3397 ENOG4108TN2 lmbE family CT43_CH3399 ENOG4107R3E Citrate transporter CT43_CH3402 ENOG4108MES Periplasmic binding protein CT43_CH3403 ENOG4105EHG Permease protein CT43_CH3404 ENOG4105DQ5 transport system permease protein CT43_CH3405 ENOG4105NX3 Membrane CT43_CH3409 ENOG4107CUJ Protein of unknown function (DUF2690) CT43_CH3411 ENOG4107V2S Transcriptional regulator CT43_CH3415 ENOG4105C98 muts2 protein CT43_CH3417 ENOG4105E5K Alpha-amylase CT43_CH3418 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CT43_CH3419 ENOG4105DPN Oligoendopeptidase f CT43_CH3423 ENOG4105FFC UPF0187 protein CT43_CH3426 ENOG4108A04 Beta-lactamase CT43_CH3431 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CT43_CH3434 ENOG41082BM Transcriptional regulator, arsr family CT43_CH3435 ENOG4105CB2 alcohol dehydrogenase CT43_CH3437 ENOG4107JM4 Tetratricopeptide repeat CT43_CH3442 ENOG4105CQB FAD linked oxidase domain protein CT43_CH3446 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C CT43_CH3447 ENOG4108M1A Chitin-binding protein CT43_CH3449 ENOG4105E1K spore germination protein CT43_CH3458 ENOG4105BZU Histidine kinase CT43_CH3459 ENOG4105C5H ABC transporter CT43_CH3460 ENOG41067SE Tetr family transcriptional regulator CT43_CH3461 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity CT43_CH3463 ENOG4108VXD carboxy-peptidase CT43_CH3464 ENOG4107DUR UPF0457 protein CT43_CH3468 ENOG4105BZU Histidine kinase CT43_CH3470 ENOG4105KT7 mgtC SapB transporter CT43_CH3473 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CT43_CH3474 ENOG4105EAB amino acid AbC transporter CT43_CH3476 ENOG4108HW4 amino acid AbC transporter CT43_CH3477 ENOG41073R8 VanW family CT43_CH3479 ENOG4108R1P CT43_CH3483 ENOG4105VEQ Cold shock protein CT43_CH3487 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CT43_CH3491 ENOG410904N short-chain dehydrogenase reductase CT43_CH3493 ENOG4106IQC argininosuccinate lyase CT43_CH3496 ENOG4108IA2 Sodium pantothenate symporter CT43_CH3498 ENOG4105C26 Dehydrogenase CT43_CH3499 ENOG4105CHR reductase CT43_CH3501 ENOG4105EWU Squalene--hopene cyclase CT43_CH3503 ENOG4105FR1 rard protein CT43_CH3504 ENOG410696E Membrane CT43_CH3507 ENOG4105D1F ATP-binding protein CT43_CH3509 ENOG4108ZAF Molybdopterin CT43_CH3510 ENOG4105CVM Molybdenum cofactor synthesis domain protein CT43_CH3511 ENOG4105D06 uba thif-type nad fad binding protein CT43_CH3512 ENOG4105TMB Formate nitrite transporter CT43_CH3514 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CT43_CH3515 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CT43_CH3517 ENOG4108JB9 formate dehydrogenase CT43_CH3518 ENOG4105E1K spore germination protein CT43_CH3521 ENOG4105CUB amino acid CT43_CH3530 ENOG4105DQ6 Transposase CT43_CH3534 ENOG4108KGH TRANSCRIPTIONal CT43_CH3536 ENOG4105EMN RNA polymerase sigma factor CT43_CH3539 ENOG4105CIG ABC transporter CT43_CH3543 ENOG4105D9R oxidoreductase CT43_CH3545 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CT43_CH3546 ENOG4105K4P CoA-binding domain protein CT43_CH3547 ENOG4105C0H protease CT43_CH3550 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CT43_CH3551 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CT43_CH3552 ENOG4105W8X HesB YadR YfhF-family protein CT43_CH3559 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CT43_CH3560 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CT43_CH3561 ENOG4108JJA ABC, transporter CT43_CH3562 ENOG4108I0Z Aconitate hydratase CT43_CH3568 ENOG4105E5W Transporter CT43_CH3570 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CT43_CH3574 ENOG4107F3J Amp-dependent synthetase and ligase CT43_CH3575 ENOG4107ZYJ bioY protein CT43_CH3576 ENOG4105CEY Amp-dependent synthetase and ligase CT43_CH3577 ENOG4108IMY Transcriptional regulator CT43_CH3584 ENOG4107AYK membrAne CT43_CH3586 ENOG4105BZU Histidine kinase CT43_CH3587 ENOG4105FBA Phospholipase Carboxylesterase CT43_CH3588 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CT43_CH3589 ENOG4105CK7 Sodium proline symporter CT43_CH3590 ENOG4105CBC glutamate synthase CT43_CH3591 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CT43_CH3592 ENOG4108VJ1 Transcriptional regulator (CarD family CT43_CH3593 ENOG4108903 Formimidoylglutamase CT43_CH3598 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) CT43_CH3604 ENOG4107QIV Cytochrome c biogenesis protein CT43_CH3608 ENOG4105CH2 amidohydrolase CT43_CH3610 ENOG4105CJ1 ABC, transporter CT43_CH3613 ENOG4107RSM transcriptional regulator CT43_CH3614 ENOG4105VAW lrga family CT43_CH3615 ENOG41067MG lrgb family CT43_CH3623 ENOG4105BZ1 (ABC) transporter CT43_CH3624 ENOG4105BZ1 (ABC) transporter CT43_CH3631 ENOG4108HW3 (ABC) transporter CT43_CH3632 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic CT43_CH3634 ENOG4105CGH 5'-nucleotidase CT43_CH3636 ENOG4108SVB resolvase CT43_CH3640 ENOG4105K7K Transcriptional regulator CT43_CH3641 ENOG4105C5F glutamine synthetase CT43_CH3642 ENOG4105KV4 Transcriptional regulator CT43_CH3643 ENOG4105CXI aluminum resistance protein CT43_CH3644 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CT43_CH3645 ENOG4105EN6 Membrane CT43_CH3647 ENOG4106F1P AAA ATPase, central domain protein CT43_CH3650 ENOG4105DQ6 Transposase CT43_CH3655 ENOG41069ER domain protein CT43_CH3656 ENOG4105DM4 PTS System CT43_CH3657 ENOG4105DE4 1-phosphofructokinase CT43_CH3658 ENOG4105E98 transcriptional regulator DeoR family CT43_CH3659 ENOG4107QW4 alcohol dehydrogenase CT43_CH3660 ENOG4108SJC Membrane CT43_CH3663 ENOG4105C85 amino acid CT43_CH3666 ENOG4105TMB Formate nitrite transporter CT43_CH3667 ENOG4105K70 DNA-binding protein CT43_CH3669 ENOG4105C59 p-type ATPase CT43_CH3670 ENOG410681U heavy metal transport detoxification protein CT43_CH3671 ENOG4105VPX protein, conserved in bacteria CT43_CH3675 ENOG4105NIV Esterase CT43_CH3676 ENOG4105E0A ABC, transporter CT43_CH3680 ENOG4105CGK Exodeoxyribonuclease III CT43_CH3682 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CT43_CH3683 ENOG4105D03 DNA-3-methyladenine glycosylase II CT43_CH3684 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CT43_CH3689 ENOG4105BZU Histidine kinase CT43_CH3696 ENOG41067MG lrgb family CT43_CH3700 ENOG4108S3Y transcriptional regulator CT43_CH3701 ENOG4105CS2 ec 3.2.1.21 CT43_CH3704 ENOG4105F0V Cell wall hydrolase CT43_CH3706 ENOG4105E0M Sulfatase CT43_CH3710 ENOG410890F Dynamin family CT43_CH3716 ENOG4105DQU oxidoreductase, subunit beta CT43_CH3717 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CT43_CH3718 ENOG4108IGT Dipeptidase CT43_CH3719 ENOG4105MCT stage V sporulation protein S CT43_CH3720 ENOG4105D48 metallophosphoesterase CT43_CH3724 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CT43_CH3727 ENOG4105XZV Protein of unknown function (DUF3243) CT43_CH3728 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CT43_CH3732 ENOG4105UIB (ABC) transporter CT43_CH3733 ENOG4108JQ9 ABC transporter CT43_CH3734 ENOG4105DIH basic membrane CT43_CH3735 ENOG4105FDP GntR family transcriptional regulator CT43_CH3736 ENOG4105CNU cell division protein FtsK CT43_CH3738 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CT43_CH3740 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CT43_CH3743 ENOG4108S0H Dipicolinic acid synthetase, b subunit CT43_CH3751 ENOG41085W3 Transposase CT43_CH3786 ENOG4105CDU Replicative dna helicase CT43_CH3793 ENOG4108IMY Transcriptional regulator CT43_CH3799 ENOG4108S0H Dipicolinic acid synthetase, b subunit CT43_CH3800 ENOG4105E35 Dipicolinate synthase subunit A CT43_CH3802 ENOG4105C1V Peptidase, M16 CT43_CH3806 ENOG4105DTN riboflavin biosynthesis protein ribF CT43_CH3809 ENOG4105W7A Protein of unknown function (DUF503) CT43_CH3811 ENOG4105VHM ribosomal protein CT43_CH3812 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CT43_CH3813 ENOG4105CHV Transcription elongation factor NusA CT43_CH3815 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CT43_CH3818 ENOG4105DZP Membrane-associated zinc metalloprotease CT43_CH3819 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CT43_CH3820 ENOG4105KNE Phosphatidate cytidylyltransferase CT43_CH3822 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CT43_CH3824 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CT43_CH3831 ENOG4108HE4 integrase family CT43_CH3833 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CT43_CH3834 ENOG4105C79 DNA protecting protein DprA CT43_CH3835 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CT43_CH3838 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CT43_CH3843 ENOG4105VB6 UPF0109 protein CT43_CH3847 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CT43_CH3848 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CT43_CH3851 ENOG4105CHR reductase CT43_CH3852 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CT43_CH3855 ENOG4105CB5 ATP-dependent DNA helicase recG CT43_CH3856 ENOG4105DP4 dak2 domain fusion protein ylov CT43_CH3857 ENOG4108ZAA Alkaline-shock protein CT43_CH3859 ENOG4105FJ0 thiamine CT43_CH3860 ENOG4105DJV ribulose-phosphate 3-epimerase CT43_CH3861 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CT43_CH3862 ENOG4105D9P serine threonine protein kinase CT43_CH3863 ENOG4108ZF3 Phosphatase CT43_CH3865 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CT43_CH3868 ENOG4105C25 Primosomal protein n' CT43_CH3869 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CT43_CH3873 ENOG4105DSJ YicC domain protein CT43_CH3875 ENOG4105F23 Fibronectin-binding protein CT43_CH3877 ENOG4105DC7 peptidase M24 CT43_CH3886 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CT43_CH3893 ENOG4105C34 Pseudouridine synthase CT43_CH3896 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CT43_CH3898 ENOG4105DBK s4 domain protein CT43_CH3899 ENOG41067XK integral membrane protein CT43_CH3901 ENOG4105DFA alanine racemase domain protein CT43_CH3902 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CT43_CH3903 ENOG4105WR5 sporulation protein, YlmC YmxH family CT43_CH3905 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH3907 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CT43_CH3908 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CT43_CH3910 ENOG4105D4A Cell wall formation (By similarity) CT43_CH3911 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CT43_CH3912 ENOG4105CNI cell division protein FtsW CT43_CH3915 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CT43_CH3916 ENOG4105CJN penicillin-binding protein CT43_CH3917 ENOG4105CJN penicillin-binding protein CT43_CH3920 ENOG41074B2 UPF0747 protein CT43_CH3925 ENOG4105KNH Nucleic acid-binding protein CT43_CH3927 ENOG41063PX domain protein CT43_CH3928 ENOG4105D78 K07001 NTE family protein CT43_CH3929 ENOG4105H20 Sporulation integral membrane protein YlbJ CT43_CH3931 ENOG4106H78 methyltransferase CT43_CH3935 ENOG4107TB6 phosphoglycerate mutase CT43_CH3938 ENOG4106UY4 Inherit from COG: Scp-like extracellular CT43_CH3941 ENOG4105DQ6 Transposase CT43_CH3943 ENOG4105EKQ RNA-directed DNA polymerase CT43_CH3953 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CT43_CH3954 ENOG4105CNI cell division protein FtsW CT43_CH3957 ENOG4108IAB Phoh family CT43_CH3961 ENOG4105QA2 CT43_CH3962 ENOG4105CI3 gtp-binding protein typa CT43_CH3964 ENOG4105ECY inositol monophosphatase CT43_CH3968 ENOG4105CXN decarboxylase CT43_CH3977 ENOG4105CPP Dehydrogenase, E1 component CT43_CH3980 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CT43_CH3981 ENOG4108X4Q Hydrolase CT43_CH3983 ENOG4105CN5 Metallo-Beta-Lactamase CT43_CH3984 ENOG4107ZYR domain protein CT43_CH3991 ENOG4108XRC Protein of unknown function (DUF458) CT43_CH3993 ENOG4107IN1 Protein of unknown function (DUF1797) CT43_CH3996 ENOG4105EPM Diguanylate phosphodiesterase CT43_CH3997 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CT43_CH4000 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CT43_CH4002 ENOG4105UIN CT43_CH4008 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CT43_CH4013 ENOG4108HGU Histidine kinase CT43_CH4016 ENOG4105CHM Aminotransferase CT43_CH4017 ENOG4105FKQ transcriptional regulator CT43_CH4018 ENOG4105EG2 ABC transporter, permease CT43_CH4020 ENOG4107FKK extracellular solute-binding protein family 1 CT43_CH4022 ENOG4105CG3 alpha amylase, catalytic region CT43_CH4029 ENOG4105CHU acetyl-coa acetyltransferase CT43_CH4035 ENOG4105K7K Transcriptional regulator CT43_CH4036 ENOG4105DTD Dehydrogenase CT43_CH4040 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CT43_CH4045 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CT43_CH4048 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CT43_CH4050 ENOG4105BZU Histidine kinase CT43_CH4054 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CT43_CH4058 ENOG4105CID antiterminator CT43_CH4060 ENOG4105FDP GntR family transcriptional regulator CT43_CH4062 ENOG4105CE4 GlcNAc 6-P deacetylase CT43_CH4068 ENOG4107ZE5 PPIases accelerate the folding of proteins CT43_CH4069 ENOG4105PTM secreted protein CT43_CH4070 ENOG4105J7I hydrolase CT43_CH4072 ENOG4105G6R Stage v sporulation protein ae CT43_CH4074 ENOG4105CZ3 stage V sporulation protein ad CT43_CH4075 ENOG41090VF Stage v sporulation protein ac CT43_CH4079 ENOG4105C8J )-transporter CT43_CH4080 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH4082 ENOG41082AN stage II sporulation protein CT43_CH4083 ENOG4105DZ1 carboxypeptidase CT43_CH4084 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CT43_CH4085 ENOG4105DVE abc transporter atp-binding protein CT43_CH4092 ENOG4105D7N magnesium and cobalt transport protein CorA CT43_CH4097 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CT43_CH4099 ENOG4105I3K Ferric uptake regulator, Fur family CT43_CH4100 ENOG4105MZ9 stage II sporulation protein m CT43_CH4105 ENOG4105CPC Aldo Keto reductase CT43_CH4107 ENOG4105RHY Pfam:UPF0157 CT43_CH4111 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CT43_CH4113 ENOG4108YM7 Gcn5-related n-acetyltransferase CT43_CH4117 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CT43_CH4118 ENOG4108R6K riboflavin synthase, subunit alpha CT43_CH4123 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CT43_CH4124 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CT43_CH4127 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CT43_CH4129 ENOG4105DFD Na H antiporter CT43_CH4130 ENOG4105CGH 5'-nucleotidase CT43_CH4142 ENOG4105DBV ornithine carbamoyltransferase CT43_CH4145 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CT43_CH4148 ENOG4108IXY short-chain dehydrogenase reductase CT43_CH4149 ENOG41069FQ Metallo-beta-lactamase superfamily CT43_CH4150 ENOG4105II7 pyrroline-5-carboxylate reductase CT43_CH4151 ENOG4105EJQ L-serine dehydratase CT43_CH4157 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CT43_CH4160 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CT43_CH4161 ENOG4105D9U N-acetyltransferase CT43_CH4163 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CT43_CH4164 ENOG4108QEG Membrane CT43_CH4165 ENOG4105CDA abc transporter atp-binding protein CT43_CH4166 ENOG4105E5Q amino acid AbC transporter CT43_CH4167 ENOG4108HW3 (ABC) transporter CT43_CH4169 ENOG4105G7B Protein of unknown function (DUF2992) CT43_CH4171 ENOG4108QY0 Membrane CT43_CH4173 ENOG4105C7S Dehydrogenase CT43_CH4174 ENOG4105CPP Dehydrogenase, E1 component CT43_CH4177 ENOG4105CKM Branched-chain carboxylic acid kinase CT43_CH4178 ENOG4107RDP Dehydrogenase CT43_CH4180 ENOG4108JUB Transcriptional regulator CT43_CH4182 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CT43_CH4185 ENOG4107QQR Sporulation CT43_CH4186 ENOG4105S1Z Stage IV sporulation protein B CT43_CH4187 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CT43_CH4188 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CT43_CH4189 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CT43_CH4190 ENOG4105DX0 Hemolysin A CT43_CH4192 ENOG4105CTB Polyprenyl synthetase CT43_CH4195 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CT43_CH4197 ENOG4108ZSR alkaline shock protein CT43_CH4198 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CT43_CH4202 ENOG410644B Stage III sporulation protein af CT43_CH4204 ENOG4105KQ4 Stage iii sporulation protein ad CT43_CH4205 ENOG4108CQH stage III sporulation protein AC CT43_CH4206 ENOG4105KR5 Stage iii sporulation protein CT43_CH4207 ENOG4105CD2 stage iii sporulation protein aa CT43_CH4212 ENOG4105DC7 peptidase M24 CT43_CH4213 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CT43_CH4215 ENOG4105CBJ Metal-dependent enzyme CT43_CH4217 ENOG4107YBY Hydrolase CT43_CH4223 ENOG41082GG biotin lipoate A B protein ligase CT43_CH4224 ENOG4105WZW rhodanese family CT43_CH4229 ENOG41080TC multidrug resistance protein CT43_CH4236 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CT43_CH4242 ENOG4105C0D helicase CT43_CH4259 ENOG4107R6U sodium dicarboxylate symporter CT43_CH4267 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CT43_CH4268 ENOG4105D7V transposase CT43_CH4269 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CT43_CH4270 ENOG4105C3R Methionine synthase CT43_CH4272 ENOG4105C28 cystathionine CT43_CH4273 ENOG4105C28 cystathionine CT43_CH4277 ENOG4105C5X domain protein CT43_CH4279 ENOG4105DKQ ROK family CT43_CH4281 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CT43_CH4284 ENOG4108UTW Plays a role in the regulation of phosphate uptake CT43_CH4285 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CT43_CH4286 ENOG4105C8U phosphate abc transporter CT43_CH4287 ENOG4105C8U phosphate abc transporter CT43_CH4288 ENOG4105EXS phosphate abc transporter CT43_CH4289 ENOG4107RF6 penicillin-binding protein CT43_CH4291 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CT43_CH4296 ENOG4105N80 Ferric uptake regulator, Fur family CT43_CH4298 ENOG4105FDK ABC transporter CT43_CH4299 ENOG4108JYZ YitT family CT43_CH4300 ENOG41069ZM Protein of unknown function (DUF2624) CT43_CH4305 ENOG4105EGD dinuclear metal center protein, YbgI family CT43_CH4308 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH4309 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CT43_CH4316 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CT43_CH4317 ENOG4105KG3 cytidine deaminase CT43_CH4318 ENOG4107YR5 Diacylglycerol kinase CT43_CH4319 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CT43_CH4320 ENOG4105CTJ Metal Dependent Phosphohydrolase CT43_CH4321 ENOG4105C9A Phoh family CT43_CH4323 ENOG41068P3 sporulation protein YqfC CT43_CH4325 ENOG4105KTH gatB Yqey CT43_CH4327 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CT43_CH4328 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CT43_CH4334 ENOG4105CSA Coproporphyrinogen iii oxidase CT43_CH4335 ENOG4105KVH Transcriptional regulator CT43_CH4340 ENOG4105TQK DNA polymerase iii, delta' subunit CT43_CH4342 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CT43_CH4343 ENOG4108UK2 deaminase CT43_CH4344 ENOG4105KQC Competence protein CT43_CH4346 ENOG4105DXX methyltransferase CT43_CH4348 ENOG4108WF2 Metal Dependent Phosphohydrolase CT43_CH4350 ENOG410812S Rna-binding protein CT43_CH4352 ENOG4105CQW ribosome biogenesis GTPase YqeH CT43_CH4353 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CT43_CH4356 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH4360 ENOG4108TVJ Nitroreductase CT43_CH4363 ENOG4105G6Z alkaline phosphatase CT43_CH4364 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CT43_CH4365 ENOG4108MUZ hydrolase CT43_CH4372 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CT43_CH4374 ENOG4105MIR Phenylalanine 4-monooxygenase CT43_CH4376 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CT43_CH4384 ENOG4105S6R Iron-hydroxamate transporter permease subunit CT43_CH4385 ENOG4108V5C ABC transporter CT43_CH4388 ENOG4108EKI Dehydrogenase CT43_CH4389 ENOG4105C28 cystathionine CT43_CH4395 ENOG4107XRG penicillin-binding protein CT43_CH4396 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CT43_CH4398 ENOG4105CFP Peptidase U32 CT43_CH4399 ENOG4105XYU peptidase (U32 family) CT43_CH4400 ENOG4108VQJ O-methyltransferase CT43_CH4401 ENOG4105HHA aminodeoxychorismate lyase CT43_CH4405 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CT43_CH4407 ENOG4105C02 permease CT43_CH4410 ENOG41060CR CT43_CH4411 ENOG4105C7H Helicase, RecD TraA family CT43_CH4413 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CT43_CH4414 ENOG4105C3J Cysteine desulfurase CT43_CH4416 ENOG4105D1H recombination factor protein RarA CT43_CH4417 ENOG4108VCI transcription factor, rsfa family CT43_CH4418 ENOG4105CUZ uba thif-type nad fad binding protein CT43_CH4420 ENOG4105CUT histidyl-tRNA synthetase CT43_CH4422 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CT43_CH4423 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CT43_CH4425 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CT43_CH4426 ENOG41076HS cation diffusion facilitator family transporter CT43_CH4427 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CT43_CH4429 ENOG4105CKP Polysaccharide Biosynthesis Protein CT43_CH4430 ENOG4108QG2 Membrane CT43_CH4432 ENOG4105VIE preprotein translocase, subunit YajC CT43_CH4435 ENOG41061AI Protein of unknown function (DUF2905) CT43_CH4438 ENOG4108HUF Transporter CT43_CH4444 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CT43_CH4445 ENOG4108IYU L-aspartate oxidase CT43_CH4448 ENOG4108RPX mosc domain containing protein CT43_CH4449 ENOG4105CQC Prephenate dehydratase CT43_CH4452 ENOG4105C19 ABC transporter CT43_CH4453 ENOG4105EWM Histidine kinase CT43_CH4455 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CT43_CH4458 ENOG4105X36 (ribosomal) protein CT43_CH4460 ENOG4105C03 ribonuclease CT43_CH4463 ENOG4107QMS site-determining protein CT43_CH4466 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CT43_CH4467 ENOG4105DFF Rod shape-determining protein mreb CT43_CH4471 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CT43_CH4472 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CT43_CH4474 ENOG41068KH stage VI sporulation protein D CT43_CH4476 ENOG4105D52 delta-aminolevulinic acid dehydratase CT43_CH4481 ENOG4105K56 Transcriptional regulator CT43_CH4485 ENOG4108IUQ atp-dependent protease CT43_CH4490 ENOG4108QCI YvbH-like oligomerisation region CT43_CH4511 ENOG4105M59 Phosphodiesterase, mj0936 family CT43_CH4514 ENOG4108XJQ germination protein CT43_CH4516 ENOG4108PCX Major Facilitator CT43_CH4518 ENOG4105KBX Transcriptional regulator, TetR family CT43_CH4520 ENOG4105PFC Transcriptional regulator CT43_CH4522 ENOG4105DZC cytosine deaminase CT43_CH4523 ENOG41067S9 phage shock protein C, PspC CT43_CH4524 ENOG4108JCI Transcriptional regulator CT43_CH4526 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CT43_CH4527 ENOG4108Z40 Transcriptional regulator CT43_CH4528 ENOG4105RHA ABC transporter, permease CT43_CH4529 ENOG4108IUX (ABC) transporter CT43_CH4530 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family CT43_CH4531 ENOG4105ER2 Ompa motb domain protein CT43_CH4532 ENOG4105E14 MotA TolQ exbB proton channel CT43_CH4533 ENOG4108VXD carboxy-peptidase CT43_CH4535 ENOG4105E33 succinate dehydrogenase CT43_CH4537 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CT43_CH4539 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CT43_CH4540 ENOG4105K63 Thioredoxin CT43_CH4541 ENOG4105C10 Electron transfer flavoprotein CT43_CH4542 ENOG4105BZJ Electron transfer flavoprotein CT43_CH4543 ENOG41060WC Enoyl-CoA hydratase CT43_CH4544 ENOG4107Z3H Transcriptional regulator, TetR family CT43_CH4545 ENOG4105CEY Amp-dependent synthetase and ligase CT43_CH4547 ENOG4105J76 Periplasmic binding protein CT43_CH4548 ENOG4105S6R Iron-hydroxamate transporter permease subunit CT43_CH4558 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CT43_CH4561 ENOG4105DR4 Methyltransferase CT43_CH4563 ENOG4105KFN sortase, SrtB family CT43_CH4564 ENOG4105E0A ABC, transporter CT43_CH4567 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CT43_CH4569 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) CT43_CH4571 ENOG4105FE9 pseudouridine synthase CT43_CH4573 ENOG4105DCG PHP domain protein CT43_CH4576 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CT43_CH4578 ENOG4105C5S asparaginyl-tRNA synthetase CT43_CH4579 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CT43_CH4581 ENOG4108RWN rrna methyltransferase CT43_CH4587 ENOG4105C0R drug resistance transporter emrb qaca subfamily CT43_CH4588 ENOG4105CW7 secretion protein, HlyD family CT43_CH4589 ENOG4108JGH Tetr family transcriptional regulator CT43_CH4590 ENOG4105CN9 Peptidase m42 family protein CT43_CH4594 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CT43_CH4595 ENOG4105C22 threonyL-tRNA synthetase CT43_CH4596 ENOG4108TDW sporulation protein YtxC CT43_CH4600 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CT43_CH4602 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CT43_CH4603 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CT43_CH4605 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CT43_CH4606 ENOG4105C2M dna polymerase I CT43_CH4607 ENOG4105BZU Histidine kinase CT43_CH4608 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CT43_CH4613 ENOG4108HMX isocitrate dehydrogenase (NADP) CT43_CH4614 ENOG4105BZN citrate synthase CT43_CH4616 ENOG4108REF Sporulation integral membrane protein ytvi CT43_CH4617 ENOG4105FS0 cytoplasmic membrane protein CT43_CH4622 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CT43_CH4623 ENOG4105C6K Malic enzyme CT43_CH4624 ENOG4105C0B DNA polymerase III (alpha subunit) CT43_CH4625 ENOG4105VV2 CT43_CH4627 ENOG4105SFS phosphoesterase RecJ domain protein CT43_CH4634 ENOG4105DC7 peptidase M24 CT43_CH4641 ENOG4105Z7P Acetyltransferase (GNAT) family CT43_CH4642 ENOG41082W1 Cupin 2, conserved barrel domain protein CT43_CH4646 ENOG4107YZX Universal stress protein CT43_CH4655 ENOG4108JYZ YitT family CT43_CH4659 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CT43_CH4661 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CT43_CH4662 ENOG4105KBJ sporulation protein ytfj CT43_CH4665 ENOG4105EFZ amidohydrolase CT43_CH4667 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CT43_CH4672 ENOG4105RQF LysR family Transcriptional regulator CT43_CH4674 ENOG4105U5Y Transcriptional regulator CT43_CH4676 ENOG4105C28 cystathionine CT43_CH4682 ENOG4105EMN RNA polymerase sigma factor CT43_CH4684 ENOG4108UW5 maltose o-acetyltransferase CT43_CH4686 ENOG4105F1V Acetoin utilization protein CT43_CH4687 ENOG4105W87 Cbs domain CT43_CH4688 ENOG4105DGU Histone deacetylase CT43_CH4689 ENOG4106HB6 Alpha beta hydrolase CT43_CH4691 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CT43_CH4692 ENOG4105BZU Histidine kinase CT43_CH4693 ENOG4107SNB ankyrin repeat protein YahD CT43_CH4694 ENOG4105EP9 oxidoreductase CT43_CH4699 ENOG4105ETE Transcriptional regulator (LacI family CT43_CH4704 ENOG4105C88 aminopeptidase CT43_CH4708 ENOG4108IPJ Membrane CT43_CH4715 ENOG4108VDD TRNA binding domain protein CT43_CH4721 ENOG4105C8F Beta-lactamase domain protein CT43_CH4723 ENOG4108V15 phosphotransferase enzyme family CT43_CH4724 ENOG4108IUM Glycogen debranching enzyme CT43_CH4726 ENOG4107QSE Dipeptidase CT43_CH4727 ENOG4105YW5 deoR family transcriptional regulator CT43_CH4730 ENOG4105CBX hi0933 family CT43_CH4737 ENOG4108VJ1 Transcriptional regulator (CarD family CT43_CH4738 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CT43_CH4739 ENOG4105CSC Glucose uptake protein CT43_CH4742 ENOG4108ZAF Molybdopterin CT43_CH4743 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CT43_CH4744 ENOG4105CVM Molybdenum cofactor synthesis domain protein CT43_CH4746 ENOG4105D06 uba thif-type nad fad binding protein CT43_CH4747 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CT43_CH4751 ENOG41085GJ domain protein CT43_CH4753 ENOG4105DWV Homoserine O-trans-acetylase CT43_CH4755 ENOG4108B31 Spore germination protein CT43_CH4760 ENOG4105C8T Leucyl-tRNA synthetase CT43_CH4761 ENOG410605W Major Facilitator CT43_CH4762 ENOG4107S91 Sodium hydrogen exchanger CT43_CH4763 ENOG4105NCW Trka-c domain protein CT43_CH4766 ENOG4105C19 ABC transporter CT43_CH4768 ENOG4105D7V transposase CT43_CH4772 ENOG4105N5T Radical SAM Protein CT43_CH4774 ENOG4105DA5 (ABC) transporter CT43_CH4780 ENOG4105E8V Alpha Beta Hydrolase Fold protein CT43_CH4781 ENOG4108Z0R Transferase CT43_CH4782 ENOG4105YVM Phosphoesterase, PA-phosphatase related CT43_CH4783 ENOG4105BZF Glycosyl transferase (Group 1 CT43_CH4785 ENOG4105EPU Molybdenum cofactor synthesis domain protein CT43_CH4800 ENOG4105BZU Histidine kinase CT43_CH4801 ENOG4105BZU Histidine kinase CT43_CH4802 ENOG4105CH6 catalase CT43_CH4803 ENOG4107S9D Alpha beta hydrolase CT43_CH4804 ENOG4107T7U Sulfatase CT43_CH4808 ENOG4105D2X ABC transporter substrate-binding protein CT43_CH4810 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CT43_CH4819 ENOG41080TC multidrug resistance protein CT43_CH4820 ENOG410839T multidrug resistance protein CT43_CH4823 ENOG4108V2W Carbonate dehydratase CT43_CH4824 ENOG4105C4M (Ubiquinol oxidase) subunit I CT43_CH4825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CT43_CH4832 ENOG41087YS Phage shock protein A CT43_CH4837 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CT43_CH4838 ENOG4105BZU Histidine kinase CT43_CH4839 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH4844 ENOG4108UGV hypoxanthine phosphoribosyltransferase CT43_CH4845 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CT43_CH4848 ENOG4105C19 ABC transporter CT43_CH4850 ENOG4107ZTW SNARE associated Golgi CT43_CH4853 ENOG4105C19 ABC transporter CT43_CH4854 ENOG41086D8 Transcriptional regulator CT43_CH4857 ENOG41082BM Transcriptional regulator, arsr family CT43_CH4867 ENOG4105C6Z Gluconate CT43_CH4868 ENOG4105FDP GntR family transcriptional regulator CT43_CH4872 ENOG41069H0 dihydroorotase EC 3.5.2.3 CT43_CH4876 ENOG4105DTQ mandelate racemase muconate lactonizing CT43_CH4877 ENOG4105CEY Amp-dependent synthetase and ligase CT43_CH4878 ENOG4108IPT Naphthoate synthase CT43_CH4879 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CT43_CH4880 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CT43_CH4881 ENOG4105E4F Isochorismate synthase CT43_CH4882 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CT43_CH4884 ENOG4105VEQ Cold shock protein CT43_CH4892 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CT43_CH4893 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CT43_CH4895 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CT43_CH4898 ENOG4105KT7 mgtC SapB transporter CT43_CH4899 ENOG4107PBV potassium channel CT43_CH4902 ENOG4105WG9 Conserved Protein CT43_CH4904 ENOG4105CHM Aminotransferase CT43_CH4905 ENOG4108ZB6 transcriptional regulator AsnC family CT43_CH4906 ENOG4105C5I Dehydrogenase CT43_CH4907 ENOG4108MUZ hydrolase CT43_CH4909 ENOG4105C87 Aminotransferase class I and II CT43_CH4912 ENOG4105Y38 Kinase-associated protein B CT43_CH4914 ENOG4107R3E Citrate transporter CT43_CH4917 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CT43_CH4918 ENOG4105KA0 thioesterase Superfamily protein CT43_CH4921 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CT43_CH4926 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CT43_CH4927 ENOG4106YN8 Prenyltransferase CT43_CH4929 ENOG41069ER domain protein CT43_CH4932 ENOG4105CEP NADH dehydrogenase CT43_CH4938 ENOG4105EWC Purine nucleoside phosphorylase CT43_CH4949 ENOG4105XSJ toxin secretion phage lysis holin CT43_CH4975 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH4980 ENOG4108ZUE Phage regulatory protein rha CT43_CH4985 ENOG4108IMY Transcriptional regulator CT43_CH4992 ENOG4108VQJ O-methyltransferase CT43_CH4995 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CT43_CH5000 ENOG4108JJA ABC, transporter CT43_CH5001 ENOG4105C4B ABC transporter, permease CT43_CH5002 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CT43_CH5008 ENOG41083MR nifu domain-containing protein CT43_CH5011 ENOG4108W5N phosphatidylglycerophosphatase a CT43_CH5015 ENOG4105DAX Pfam:DUF2983 CT43_CH5017 ENOG4105DYS nad(p)h dehydrogenase (quinone) CT43_CH5018 ENOG4105D4U had-superfamily hydrolase, subfamily iia CT43_CH5021 ENOG4105CBT Fructose-1,6-bisphosphatase CT43_CH5025 ENOG4105MMD transcriptional regulator CT43_CH5026 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CT43_CH5027 ENOG4107TXC Transcriptional regulator CT43_CH5028 ENOG41090T1 Membrane CT43_CH5033 ENOG4105FAA peptidase M23 CT43_CH5034 ENOG4108YTE sporulation protein YunB CT43_CH5035 ENOG4105KZD Domain of unknown function (DUF1805) CT43_CH5036 ENOG4107R8B 5'-nucleotidase CT43_CH5037 ENOG4105DIW FeS assembly protein SUFB CT43_CH5038 ENOG4108UNV SUF system FeS assembly protein, NifU family CT43_CH5039 ENOG4105C9B Cysteine desulfurase CT43_CH5040 ENOG4105JRK feS assembly protein SufD CT43_CH5041 ENOG4105C3K feS assembly ATPase SufC CT43_CH5042 ENOG4105D01 (LipO)protein CT43_CH5043 ENOG4105D01 (LipO)protein CT43_CH5044 ENOG4108UMI ABC transporter, permease CT43_CH5045 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CT43_CH5050 ENOG41080E8 Transcriptional regulator, Spx MgsR family CT43_CH5058 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CT43_CH5064 ENOG4108W8B Beta-lactamase domain protein CT43_CH5065 ENOG4105C1G acyl-Coa dehydrogenase CT43_CH5066 ENOG4105CHU acetyl-coa acetyltransferase CT43_CH5069 ENOG4105DZ1 carboxypeptidase CT43_CH5073 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CT43_CH5075 ENOG4108SUT Major Facilitator Superfamily CT43_CH5076 ENOG4107R7I amino acid CT43_CH5080 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CT43_CH5082 ENOG4107AYK membrAne CT43_CH5089 ENOG4107ZTW SNARE associated Golgi CT43_CH5091 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CT43_CH5092 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH5093 ENOG4105BZU Histidine kinase CT43_CH5099 ENOG4105C8Q Methyl-accepting chemotaxis CT43_CH5100 ENOG4105C8Q Methyl-accepting chemotaxis CT43_CH5101 ENOG4105VG1 fes assembly suf system protein CT43_CH5102 ENOG4105D4Y metalloprotease CT43_CH5103 ENOG4105C2I pirin domain protein CT43_CH5106 ENOG4107T5V SNARE associated Golgi CT43_CH5107 ENOG4107S91 Sodium hydrogen exchanger CT43_CH5108 ENOG4105NCW Trka-c domain protein CT43_CH5110 ENOG4108RMU ferritin dps family protein CT43_CH5114 ENOG4108URH decarboxylase CT43_CH5116 ENOG41090A1 ferritin CT43_CH5118 ENOG4105D9N nucleoside CT43_CH5119 ENOG4105D9N nucleoside CT43_CH5123 ENOG4108RYK Nad-dependent epimerase dehydratase CT43_CH5126 ENOG4105CV8 reductase CT43_CH5127 ENOG4105F27 Major Facilitator CT43_CH5128 ENOG4105KVH Transcriptional regulator CT43_CH5131 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CT43_CH5132 ENOG4105D4A Cell wall formation (By similarity) CT43_CH5137 ENOG4105WMR Protein CrcB homolog CT43_CH5138 ENOG4105WMR Protein CrcB homolog CT43_CH5141 ENOG4108MK9 spermidine N(1)-acetyltransferase CT43_CH5142 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CT43_CH5144 ENOG4108W2Y isochorismatase CT43_CH5150 ENOG4108IPW abc transporter atp-binding protein CT43_CH5151 ENOG4105CM4 permease protein CT43_CH5157 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CT43_CH5159 ENOG4105XZU Preprotein translocase, subunit SecG CT43_CH5160 ENOG41067MG lrgb family CT43_CH5170 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH5173 ENOG4105BZU Histidine kinase CT43_CH5174 ENOG4108W5X Transcriptional Regulator, LuxR family CT43_CH5177 ENOG41090VF Stage v sporulation protein ac CT43_CH5178 ENOG4105CZ3 stage V sporulation protein ad CT43_CH5181 ENOG4108QY0 Membrane CT43_CH5182 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CT43_CH5183 ENOG4105KRI phosphocarrier protein (HPr CT43_CH5185 ENOG4105CHW UPF0052 protein CT43_CH5186 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CT43_CH5187 ENOG4108Z4K mutator MutT protein CT43_CH5189 ENOG4105C3M thioredoxin reductase CT43_CH5191 ENOG4108S4C acetyltransferase CT43_CH5195 ENOG41086DT Membrane protein of unknown function CT43_CH5197 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CT43_CH5201 ENOG4107TXC Transcriptional regulator CT43_CH5205 ENOG4105DUM transcriptional regulator, lysR family CT43_CH5207 ENOG4108WS4 fmn reductase CT43_CH5209 ENOG4105BZ1 (ABC) transporter CT43_CH5211 ENOG4105CN1 protease CT43_CH5212 ENOG4105CRP Part of the ABC transporter FtsEX involved in CT43_CH5213 ENOG4105CAK Cell division ATP-binding protein ftsE CT43_CH5217 ENOG4105MS2 ribosomal subunit Interface protein CT43_CH5219 ENOG4105VEQ Cold shock protein CT43_CH5220 ENOG41081UC Inherit from COG: Competence protein CT43_CH5223 ENOG4105KVH Transcriptional regulator CT43_CH5225 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CT43_CH5226 ENOG4108KGH TRANSCRIPTIONal CT43_CH5227 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CT43_CH5228 ENOG4105C6Y Udp-glucose 6-dehydrogenase CT43_CH5229 ENOG4105ESV Glycosyl transferase, family 4 CT43_CH5231 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CT43_CH5235 ENOG4105F8D glycoside hydrolase family 4 CT43_CH5236 ENOG4105VCP PTS System CT43_CH5237 ENOG4105CK1 PTS System CT43_CH5239 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CT43_CH5240 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CT43_CH5241 ENOG4105VCP PTS System CT43_CH5243 ENOG4105VZJ PTS System CT43_CH5247 ENOG4105ECB domain protein CT43_CH5248 ENOG4107RSM transcriptional regulator CT43_CH5256 ENOG4105DAA L-lactate CT43_CH5258 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) CT43_CH5260 ENOG4105E0M Sulfatase CT43_CH5268 ENOG4107R8N Glycosyl transferase, family 2 CT43_CH5270 ENOG4105C94 Transporter CT43_CH5271 ENOG41069ER domain protein CT43_CH5276 ENOG4105KBK Zinc finger, swim domain protein CT43_CH5277 ENOG4105C0D helicase CT43_CH5279 ENOG41085W3 Transposase CT43_CH5284 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CT43_CH5286 ENOG4107RBB ABC transporter, permease CT43_CH5287 ENOG4105C19 ABC transporter CT43_CH5291 ENOG4105CXY transporter CT43_CH5294 ENOG4105BZU Histidine kinase CT43_CH5295 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH5296 ENOG4105DG6 mannose-6-phosphate isomerase CT43_CH5297 ENOG4105DM4 PTS System CT43_CH5299 ENOG4105CMR udp-glucose 4-epimerase CT43_CH5301 ENOG4108KGH TRANSCRIPTIONal CT43_CH5302 ENOG4105DG6 mannose-6-phosphate isomerase CT43_CH5303 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CT43_CH5305 ENOG4107T8Q Glycosyl transferase (Group 1 CT43_CH5306 ENOG4107EF8 Glycosyl transferase (Group 1 CT43_CH5308 ENOG4107RA4 Glycosyl transferase (Group 1 CT43_CH5309 ENOG4108UW5 maltose o-acetyltransferase CT43_CH5312 ENOG4105D3Q Sugar transferase CT43_CH5313 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CT43_CH5314 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CT43_CH5315 ENOG4107YJ4 chain length determinant protein CT43_CH5316 ENOG4105HTX biosynthesis protein CT43_CH5317 ENOG4107YJ4 chain length determinant protein CT43_CH5320 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CT43_CH5322 ENOG4105FRN stage II sporulation protein CT43_CH5325 ENOG4105DY9 regulatoR CT43_CH5329 ENOG4106778 Protein of unknown function (DUF1146) CT43_CH5330 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CT43_CH5331 ENOG4105C8S subunit m CT43_CH5332 ENOG4105D65 subunit l CT43_CH5337 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CT43_CH5338 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CT43_CH5340 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CT43_CH5341 ENOG4105BZU Histidine kinase CT43_CH5351 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CT43_CH5352 ENOG41062M3 atp synthase CT43_CH5356 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CT43_CH5357 ENOG4108UIC UPF0340 protein CT43_CH5358 ENOG4108YZG isomerase CT43_CH5361 ENOG4108VGI doxx family CT43_CH5362 ENOG4107XC4 flavin reductase domain protein, FMN-binding CT43_CH5365 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CT43_CH5367 ENOG4108ZXQ stage ii sporulation protein r CT43_CH5368 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CT43_CH5369 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CT43_CH5372 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CT43_CH5373 ENOG4105CBT Fructose-1,6-bisphosphatase CT43_CH5374 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CT43_CH5378 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CT43_CH5381 ENOG4105C1G acyl-Coa dehydrogenase CT43_CH5382 ENOG4105C1G acyl-Coa dehydrogenase CT43_CH5383 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CT43_CH5385 ENOG4105DF6 Fe-S oxidoreductase CT43_CH5388 ENOG4105BZU Histidine kinase CT43_CH5391 ENOG4105D4Y metalloprotease CT43_CH5393 ENOG4105BZU Histidine kinase CT43_CH5394 ENOG4105KCT ABC transporter CT43_CH5395 ENOG4108M15 ABC transporter CT43_CH5396 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CT43_CH5398 ENOG4105IIU Aminopeptidase CT43_CH5402 ENOG4105EMN RNA polymerase sigma factor CT43_CH5404 ENOG410684U Domain of unknown function (DUF1934) CT43_CH5409 ENOG4105CYW agmatinase CT43_CH5411 ENOG4105DXB Major Facilitator superfamily CT43_CH5412 ENOG4107SWG transcriptional regulator MERR family CT43_CH5414 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CT43_CH5415 ENOG4105BZ4 penicillin-binding protein CT43_CH5416 ENOG4108XFG YwhD family CT43_CH5417 ENOG4108Z4T Peptidase M50 CT43_CH5418 ENOG41069HH 4-oxalocrotonate tautomerase CT43_CH5419 ENOG4105DCI Phosphohydrolase CT43_CH5420 ENOG4108MES Periplasmic binding protein CT43_CH5421 ENOG4105E0A ABC, transporter CT43_CH5422 ENOG4105EHG Permease protein CT43_CH5423 ENOG4105DQ5 transport system permease protein CT43_CH5425 ENOG4108VCI transcription factor, rsfa family CT43_CH5426 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CT43_CH5427 ENOG4108IJ2 phosphate acetyltransferase CT43_CH5428 ENOG4107UEZ chlorite dismutase CT43_CH5430 ENOG4108VKI Cell wall hydrolase CT43_CH5434 ENOG4107SVH Potassium channel protein CT43_CH5436 ENOG410667J hydrolase CT43_CH5437 ENOG4105VCH membrane CT43_CH5439 ENOG4108TU7 Inherit from COG: (ABC) transporter CT43_CH5440 ENOG4105CJ1 ABC, transporter CT43_CH5441 ENOG41090WU lipolytic protein G-D-S-L family CT43_CH5444 ENOG4105D6E homoserine dehydrogenase CT43_CH5445 ENOG4105CVG Homoserine O-transsuccinylase CT43_CH5449 ENOG4108Y4K DNA-binding transcriptional activator CT43_CH5451 ENOG4105WH1 Two component transcriptional regulator luxr family CT43_CH5452 ENOG4105BZU Histidine kinase CT43_CH5453 ENOG4105DWF phosphomethylpyrimidine kinase CT43_CH5454 ENOG4105BZU Histidine kinase CT43_CH5455 ENOG4105VCD cytoplasmic protein CT43_CH5456 ENOG4105D22 carbon starvation protein CT43_CH5457 ENOG4105DY9 regulatoR CT43_CH5461 ENOG4105CG5 Glycosyl transferase (Group 1 CT43_CH5463 ENOG4105EN6 Membrane CT43_CH5464 ENOG4106YBV Methyl-accepting chemotaxis CT43_CH5466 ENOG4108S4H thioesterase Superfamily protein CT43_CH5467 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CT43_CH5469 ENOG4105K64 Glycosyl transferase, family 2 CT43_CH5471 ENOG4105EJV Membrane CT43_CH5472 ENOG4105CKK Glycosyl transferase, family 2 CT43_CH5474 ENOG4108IG5 Transcriptional regulator CT43_CH5475 ENOG4105C5H ABC transporter CT43_CH5476 ENOG41067SE Tetr family transcriptional regulator CT43_CH5478 ENOG4105E0X reductase CT43_CH5479 ENOG4106F5Q Membrane CT43_CH5482 ENOG4108NEV two component transcriptional regulator, LytTR family CT43_CH5483 ENOG4108HRK Histidine kinase CT43_CH5484 ENOG4107RGD Major Facilitator superfamily CT43_CH5487 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CT43_CH5489 ENOG4105IW1 AmiS UreI transporter CT43_CH5491 ENOG4105CMR udp-glucose 4-epimerase CT43_CH5492 ENOG4108UT2 hemolysin iii CT43_CH5494 ENOG4105C1J atp-dependent rna helicase CT43_CH5497 ENOG4105DPN Oligoendopeptidase f CT43_CH5499 ENOG4105BZU Histidine kinase CT43_CH5502 ENOG4105C0H protease CT43_CH5503 ENOG4105Q2H domain protein CT43_CH5506 ENOG4105BZU Histidine kinase CT43_CH5507 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CT43_CH5508 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CT43_CH5509 ENOG4105CDU Replicative dna helicase CT43_CH5511 ENOG4105BZR domain protein CT43_CH5512 ENOG4108XMW Membrane CT43_CH5514 ENOG4108UUM single-stranded DNA-binding protein CT43_CH5516 ENOG4105C3G gtp-binding protein CT43_CH5517 ENOG4105VDK protein, conserved in bacteria CT43_CH5518 ENOG4105D8X mechanosensitive ion channel CT43_CH5519 ENOG4108ZDA Sporulation protein YyaC CT43_CH5520 ENOG4105FA0 parb-like partition protein CT43_CH5521 ENOG4107QJE Chromosome Partitioning Protein CT43_CH5524 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CT43_CH5525 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CT43_CH5527 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CT43_P127018 ENOG4105EKQ RNA-directed DNA polymerase CT43_P127024 ENOG4108KU9 integrase family CT43_P127025 ENOG4108FPN Integrase CT43_P127026 ENOG4105K70 DNA-binding protein CT43_P127029 ENOG4105D7V transposase CT43_P127032 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) CT43_P127034 ENOG4105E2X shikimate dehydrogenase CT43_P127042 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CT43_P127056 ENOG4105K4H Nlp p60 protein CT43_P127058 ENOG4105EKQ RNA-directed DNA polymerase CT43_P127077 ENOG4105EKQ RNA-directed DNA polymerase CT43_P127094 ENOG4105DR5 peptidase CT43_P281003 ENOG4105XSJ toxin secretion phage lysis holin CT43_P281012 ENOG4105D7V transposase CT43_P281017 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CT43_P281022 ENOG4107RT3 EamA-like transporter family CT43_P281031 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CT43_P281043 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CT43_P281048 ENOG4108J59 Extracellular solute-binding protein, family 5 CT43_P281049 ENOG4105KRN Transcriptional regulator, abrb family CT43_P281053 ENOG4105K70 DNA-binding protein CT43_P281057 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CT43_P281058 ENOG4108FPN Integrase CT43_P281059 ENOG4108KU9 integrase family CT43_P281062 ENOG4107TSN permease CT43_P281071 ENOG4108WS4 fmn reductase CT43_P281072 ENOG4107V2S Transcriptional regulator CT43_P281077 ENOG410780I phosphoprotein phosphatase activity CT43_P281080 ENOG4108IBT Inherit from COG: transposase CT43_P281082 ENOG4105DHF Membrane CT43_P281092 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281094 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281096 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281100 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281112 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281143 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281146 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281148 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281149 ENOG4105CNU cell division protein FtsK CT43_P281155 ENOG4105VIZ double-strand break repair protein CT43_P281156 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CT43_P281183 ENOG4105FB9 CRISPR-associated protein CT43_P281196 ENOG4105EKQ RNA-directed DNA polymerase CT43_P281220 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) CT43_P281223 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CT43_P281224 ENOG4105DQ6 Transposase CT43_P281230 ENOG4105D7V transposase CT43_P281233 ENOG4105C7F AcnD-accessory protein PrpF CT43_P281236 ENOG4105D7V transposase CT43_P281245 ENOG41082BM Transcriptional regulator, arsr family CT43_P281251 ENOG4105CI2 imidazolone-5-propionate hydrolase CT43_P281252 ENOG4107AYK membrAne CT43_P281253 ENOG4107RSM transcriptional regulator CT43_P281266 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CT43_P281267 ENOG4105NCW Trka-c domain protein CT43_P281268 ENOG4107S91 Sodium hydrogen exchanger CT43_P281269 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CT43_P281272 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) CT43_P51024 ENOG41085W3 Transposase CT43_P51026 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis CT43_P51067 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CT43_P72004 ENOG4108KU9 integrase family CT43_P72005 ENOG4108FPN Integrase CT43_P72011 ENOG4105EKQ RNA-directed DNA polymerase CT43_P72018 ENOG4105K4H Nlp p60 protein CT43_P72053 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CT43_P72059 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CT43_P83026 ENOG41085W3 Transposase CT43_P83040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CT43_P83052 ENOG4105KRN Transcriptional regulator, abrb family CT43_P83085 ENOG4105EKQ RNA-directed DNA polymerase