locus-tag	class	description
I8N73_00010	COG0592	DNA-directed DNA polymerase activity
I8N73_00015	COG2501	S4 domain
I8N73_00030	COG0187	DNA topoisomerase II activity
I8N73_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N73_00070	COG0516	GMP reductase activity
I8N73_00070	COG0517	IMP dehydrogenase activity
I8N73_00075	COG1686	Belongs to the peptidase S11 family
I8N73_00095	COG1929	Belongs to the glycerate kinase type-1 family
I8N73_00105	COG1428	Deoxynucleoside kinase
I8N73_00110	COG1428	Deoxynucleoside kinase
I8N73_00115	COG1388	LysM domain
I8N73_00115	COG3858	chitin binding
I8N73_00120	COG1335	isochorismatase
I8N73_00125	COG0590	tRNA wobble adenosine to inosine editing
I8N73_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I8N73_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I8N73_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I8N73_00195	COG3853	Toxic anion resistance protein (TelA)
I8N73_00200	COG1982	Orn Lys Arg decarboxylase major
I8N73_00210	COG3870	Protein conserved in bacteria
I8N73_00215	COG1728	Protein conserved in bacteria
I8N73_00220	COG0470	DNA polymerase III
I8N73_00225	COG1774	PSP1 C-terminal conserved region
I8N73_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I8N73_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I8N73_00250	COG2002	toxin-antitoxin pair type II binding
I8N73_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_00260	COG0084	hydrolase, TatD family'
I8N73_00265	COG3584	3D domain protein
I8N73_00265	COG3583	domain protein
I8N73_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N73_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I8N73_00285	COG4466	Protein conserved in bacteria
I8N73_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I8N73_00305	COG0251	oxidation-reduction process
I8N73_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I8N73_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I8N73_00345	COG2002	toxin-antitoxin pair type II binding
I8N73_00350	COG2244	polysaccharide biosynthetic process
I8N73_00355	COG3956	TIGRFAM MazG family protein
I8N73_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I8N73_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I8N73_00380	COG1098	S1 RNA binding domain
I8N73_00395	COG2208	phosphoserine phosphatase activity
I8N73_00400	COG2304	oxidoreductase activity
I8N73_00405	COG0515	serine threonine protein kinase
I8N73_00410	COG0037	tRNA processing
I8N73_00415	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I8N73_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I8N73_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N73_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N73_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N73_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
I8N73_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I8N73_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I8N73_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I8N73_00475	COG1396	sequence-specific DNA binding
I8N73_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N73_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I8N73_00565	COG4463	regulation of RNA biosynthetic process
I8N73_00570	COG3880	PFAM UvrB UvrC protein
I8N73_00580	COG0542	response to heat
I8N73_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I8N73_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I8N73_00595	COG4956	integral membrane protein (PIN domain superfamily)
I8N73_00615	COG1045	serine acetyltransferase
I8N73_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I8N73_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N73_00635	COG3688	RNA-binding protein containing a PIN domain
I8N73_00640	COG1595	DNA-templated transcription, initiation
I8N73_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N73_00655	COG0250	Participates in transcription elongation, termination and antitermination
I8N73_00680	COG2813	Specifically methylates the guanine in position
I8N73_00695	COG1358	cellular component organization or biogenesis
I8N73_00720	COG0596	Alpha beta hydrolase
I8N73_00830	COG0201	protein transport
I8N73_00840	COG0024	Methionine aminopeptidase
I8N73_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I8N73_00875	COG1122	ATPase activity
I8N73_00880	COG1122	ATPase activity
I8N73_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N73_00905	COG2226	methyltransferase
I8N73_00910	COG2318	DinB family
I8N73_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_00925	COG0489	protein tyrosine kinase activity
I8N73_00935	COG2194	sulfuric ester hydrolase activity
I8N73_00940	COG0726	polysaccharide deacetylase
I8N73_00980	COG3299	homolog of phage Mu protein gp47
I8N73_00985	COG3778	Protein conserved in bacteria
I8N73_01025	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_01025	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_01035	COG5444	nuclease activity
I8N73_01060	COG0457	Tetratricopeptide repeat
I8N73_01070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I8N73_01105	COG0738	Major facilitator superfamily
I8N73_01110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8N73_01125	COG0659	secondary active sulfate transmembrane transporter activity
I8N73_01130	COG0385	Bile acid
I8N73_01135	COG2819	hydrolase of the alpha beta superfamily
I8N73_01140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_01145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_01150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_01155	COG2207	Transcriptional regulator
I8N73_01155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_01160	COG3876	Protein conserved in bacteria
I8N73_01165	COG1472	Belongs to the glycosyl hydrolase 3 family
I8N73_01170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_01175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_01175	COG1263	PTS System
I8N73_01185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_01190	COG1683	Conserved Protein
I8N73_01220	COG1595	DNA-templated transcription, initiation
I8N73_01225	COG5662	AntiSigma factor
I8N73_01230	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N73_01235	COG4856	YbbR-like protein
I8N73_01275	COG1346	cytolysis
I8N73_01280	COG1380	Effector of murein hydrolase LrgA
I8N73_01285	COG1846	Transcriptional regulator
I8N73_01290	COG1113	amino acid transport
I8N73_01295	COG1011	Hydrolase
I8N73_01300	COG4585	Histidine kinase
I8N73_01305	COG2197	response regulator
I8N73_01310	COG1131	(ABC) transporter
I8N73_01330	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8N73_01350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_01350	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_01350	COG3321	synthase
I8N73_01350	COG4221	oxidoreductase activity
I8N73_01355	COG0300	oxidoreductase activity
I8N73_01355	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_01355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_01355	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_01355	COG3321	synthase
I8N73_01395	COG0531	amino acid
I8N73_01405	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_01410	COG2271	Major facilitator Superfamily
I8N73_01420	COG2368	4-hydroxyphenylacetate
I8N73_01430	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_01445	COG0371	Dehydrogenase
I8N73_01455	COG1183	phosphatidylcholine synthase activity
I8N73_01460	COG0586	Pfam SNARE associated Golgi protein
I8N73_01465	COG0688	phosphatidylethanolamine metabolic process
I8N73_01480	COG1301	dicarboxylic acid transport
I8N73_01485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_01490	COG0833	amino acid
I8N73_01495	COG2040	homocysteine
I8N73_01500	COG1115	amino acid carrier protein
I8N73_01505	COG2066	Belongs to the glutaminase family
I8N73_01510	COG4191	Histidine kinase
I8N73_01515	COG0784	Response regulator, receiver
I8N73_01530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_01535	COG0778	Nitroreductase
I8N73_01540	COG0346	lactoylglutathione lyase activity
I8N73_01545	COG2259	Doxx family
I8N73_01550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_01560	COG3773	Cell wall hydrolase
I8N73_01565	COG3540	Alkaline phosphatase
I8N73_01570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N73_01575	COG0805	protein transport
I8N73_01585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N73_01590	COG0477	Major facilitator Superfamily
I8N73_01595	COG1309	transcriptional regulator
I8N73_01600	COG0252	asparaginase activity
I8N73_01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I8N73_01610	COG1405	negative regulation of cell septum assembly
I8N73_01610	COG3012	SEC-C Motif Domain Protein
I8N73_01615	COG0667	Aldo Keto reductase
I8N73_01625	COG1595	DNA-templated transcription, initiation
I8N73_01630	COG1595	DNA-templated transcription, initiation
I8N73_01635	COG1876	peptidase activity
I8N73_01640	COG0457	Tetratricopeptide repeat
I8N73_01645	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_01650	COG0366	Alpha amylase catalytic
I8N73_01655	COG0803	Belongs to the bacterial solute-binding protein 9 family
I8N73_01660	COG1121	(ABC) transporter
I8N73_01665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I8N73_01670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_01675	COG2310	stress, protein
I8N73_01680	COG2310	stress, protein
I8N73_01685	COG2310	stress, protein
I8N73_01690	COG0861	Integral membrane protein TerC family
I8N73_01700	COG3853	Toxic anion resistance protein (TelA)
I8N73_01705	COG0477	Major facilitator Superfamily
I8N73_01710	COG0517	IMP dehydrogenase activity
I8N73_01710	COG4175	Glycine betaine
I8N73_01715	COG4176	ABC-type proline glycine betaine transport system permease component
I8N73_01720	COG2113	Glycine betaine
I8N73_01725	COG1473	amidohydrolase
I8N73_01730	COG1288	antiporter activity
I8N73_01740	COG0366	Alpha amylase catalytic
I8N73_01750	COG2814	Major facilitator Superfamily
I8N73_01755	COG1846	Transcriptional regulator
I8N73_01760	COG1280	lysine exporter protein (LysE YggA)
I8N73_01765	COG3403	YqcI/YcgG family
I8N73_01770	COG1113	amino acid transport
I8N73_01775	COG3665	Urea carboxylase-associated protein
I8N73_01795	COG1082	Xylose isomerase domain protein TIM barrel
I8N73_01800	COG2271	Major facilitator Superfamily
I8N73_01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I8N73_01810	COG3458	cephalosporin-C deacetylase activity
I8N73_01815	COG3541	Predicted nucleotidyltransferase
I8N73_01820	COG0506	proline dehydrogenase activity
I8N73_01825	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_01830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_01835	COG2508	Transcriptional regulator
I8N73_01845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N73_01845	COG1587	Uroporphyrinogen-III synthase
I8N73_01850	COG2146	nitrite reductase [NAD(P)H] activity
I8N73_01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N73_01860	COG0243	molybdopterin cofactor binding
I8N73_01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I8N73_01870	COG2223	nitrite transmembrane transporter activity
I8N73_01875	COG0523	cobalamin synthesis protein
I8N73_01880	COG1063	alcohol dehydrogenase
I8N73_01885	COG1714	RDD family
I8N73_01895	COG2723	6-phospho-beta-galactosidase activity
I8N73_01905	COG3209	COG3209 Rhs family protein
I8N73_01910	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I8N73_01915	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I8N73_01920	COG1733	regulation of RNA biosynthetic process
I8N73_01925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_01930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_01935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_01940	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I8N73_01955	COG0697	spore germination
I8N73_01960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_01970	COG2364	Membrane
I8N73_01975	COG1126	abc transporter atp-binding protein
I8N73_01980	COG0765	amino acid transport
I8N73_01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_01990	COG0583	DNA-binding transcription factor activity
I8N73_01995	COG0163	prenyltransferase activity
I8N73_02000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I8N73_02015	COG3104	oligopeptide transport
I8N73_02020	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_02030	COG0697	spore germination
I8N73_02040	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N73_02045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_02050	COG0456	acetyltransferase
I8N73_02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_02060	COG0765	amino acid transport
I8N73_02065	COG1126	abc transporter atp-binding protein
I8N73_02070	COG1473	amidohydrolase
I8N73_02075	COG2079	MmgE PrpD family protein
I8N73_02080	COG1136	(ABC) transporter
I8N73_02085	COG0577	efflux transmembrane transporter activity
I8N73_02090	COG0745	RESPONSE REGULATOR receiver
I8N73_02095	COG5002	protein histidine kinase activity
I8N73_02095	COG3850	Histidine kinase
I8N73_02100	COG0457	Tetratricopeptide repeat
I8N73_02115	COG0527	aspartate kinase activity
I8N73_02120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_02125	COG4605	iron ion homeostasis
I8N73_02130	COG4604	ABC transporter, ATP-binding protein
I8N73_02135	COG4607	ABC-type enterochelin transport system periplasmic component
I8N73_02140	COG2814	Major facilitator Superfamily
I8N73_02145	COG1309	transcriptional regulator
I8N73_02150	COG0778	Nitroreductase
I8N73_02155	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N73_02160	COG0640	Transcriptional regulator
I8N73_02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_02170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I8N73_02175	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_02180	COG4975	Glucose uptake
I8N73_02185	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_02190	COG4549	nuclear export factor GLE1
I8N73_02195	COG2372	response to copper ion
I8N73_02195	COG1276	copper resistance
I8N73_02200	COG1349	DNA-binding transcription factor activity
I8N73_02210	COG2213	PTS system mannitol-specific
I8N73_02215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_02225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I8N73_02235	COG0561	phosphatase activity
I8N73_02245	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N73_02255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I8N73_02260	COG1984	allophanate hydrolase subunit 2
I8N73_02265	COG1414	Transcriptional regulator
I8N73_02270	COG2755	lipolytic protein G-D-S-L family
I8N73_02280	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_02285	COG0768	penicillin binding
I8N73_02290	COG4989	oxidoreductase activity
I8N73_02295	COG3711	transcriptional antiterminator
I8N73_02300	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_02305	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_02310	COG1917	Cupin 2, conserved barrel domain protein
I8N73_02315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_02320	COG3871	stress protein (general stress protein 26)
I8N73_02330	COG2814	Major facilitator Superfamily
I8N73_02335	COG1522	sequence-specific DNA binding
I8N73_02340	COG0551	DNA topoisomerase type I activity
I8N73_02340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N73_02345	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I8N73_02350	COG3706	GGDEF domain
I8N73_02355	COG5298	Protein conserved in bacteria
I8N73_02360	COG1215	transferase activity, transferring glycosyl groups
I8N73_02370	COG0531	amino acid
I8N73_02380	COG0028	Belongs to the TPP enzyme family
I8N73_02405	COG1794	racemase activity, acting on amino acids and derivatives
I8N73_02435	COG1914	H( )-stimulated, divalent metal cation uptake system
I8N73_02445	COG4876	unkown
I8N73_02455	COG2076	Multidrug Resistance protein
I8N73_02460	COG2217	Heavy metal translocating P-type atpase
I8N73_02465	COG3729	General stress protein
I8N73_02470	COG0662	Cupin 2, conserved barrel domain protein
I8N73_02475	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_02480	COG3546	catalase activity
I8N73_02485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I8N73_02490	COG3290	protein histidine kinase activity
I8N73_02495	COG4565	transcriptional regulatory protein
I8N73_02500	COG1301	dicarboxylic acid transport
I8N73_02505	COG0628	permease
I8N73_02510	COG1131	(ABC) transporter
I8N73_02515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N73_02525	COG1960	acyl-CoA dehydrogenase activity
I8N73_02540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I8N73_02560	COG0513	Belongs to the DEAD box helicase family
I8N73_02565	COG3402	PFAM membrane-flanked domain
I8N73_02570	COG3428	Bacterial PH domain
I8N73_02575	COG0705	Rhomboid family
I8N73_02585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I8N73_02590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N73_02595	COG0864	Transcriptional regulator
I8N73_02600	COG2337	Toxic component of a toxin-antitoxin (TA) module
I8N73_02605	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_02610	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_02615	COG2172	sigma factor antagonist activity
I8N73_02620	COG2208	phosphoserine phosphatase activity
I8N73_02625	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_02635	COG1191	sigma factor activity
I8N73_02640	COG2208	phosphoserine phosphatase activity
I8N73_02645	COG2183	response to ionizing radiation
I8N73_02695	COG0582	viral genome integration into host DNA
I8N73_02700	COG2856	Zn peptidase
I8N73_02705	COG1396	sequence-specific DNA binding
I8N73_02735	COG1674	ftsk spoiiie
I8N73_02740	COG2946	Replication initiation factor
I8N73_02770	COG0433	COG0433 Predicted ATPase
I8N73_02780	COG5644	endopeptidase inhibitor activity
I8N73_02785	COG0791	NLP P60 protein
I8N73_02785	COG0741	lytic transglycosylase activity
I8N73_02800	COG0457	Tetratricopeptide repeat
I8N73_02810	COG3403	YqcI/YcgG family
I8N73_02815	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N73_02825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I8N73_02830	COG1522	sequence-specific DNA binding
I8N73_02845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8N73_02850	COG0477	Major facilitator Superfamily
I8N73_02855	COG1846	Transcriptional regulator
I8N73_02865	COG2030	dehydratase
I8N73_02880	COG1959	2 iron, 2 sulfur cluster binding
I8N73_02885	COG2910	NAD(P)H-binding
I8N73_02890	COG3239	Fatty acid desaturase
I8N73_02900	COG1278	Cold shock
I8N73_02905	COG1329	Transcriptional regulator
I8N73_02910	COG1794	racemase activity, acting on amino acids and derivatives
I8N73_02925	COG3621	Patatin-like phospholipase
I8N73_02935	COG0662	Cupin 2, conserved barrel domain protein
I8N73_02950	COG0277	FAD linked oxidase domain protein
I8N73_02980	COG2318	DinB family
I8N73_03010	COG0351	phosphomethylpyrimidine kinase
I8N73_03025	COG1064	alcohol dehydrogenase
I8N73_03030	COG0789	Transcriptional regulator
I8N73_03040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_03055	COG2814	Major facilitator Superfamily
I8N73_03060	COG1309	transcriptional regulator
I8N73_03065	COG0697	spore germination
I8N73_03070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_03075	COG5577	PFAM Coat F domain
I8N73_03085	COG1063	alcohol dehydrogenase
I8N73_03090	COG5577	PFAM Coat F domain
I8N73_03100	COG4585	Histidine kinase
I8N73_03105	COG2197	response regulator
I8N73_03110	COG2409	Drug exporters of the RND superfamily
I8N73_03115	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I8N73_03120	COG0488	(ABC) transporter
I8N73_03125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_03130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_03140	COG2814	Major facilitator Superfamily
I8N73_03150	COG0456	acetyltransferase
I8N73_03160	COG1051	belongs to the nudix hydrolase family
I8N73_03165	COG2226	methyltransferase
I8N73_03170	COG0473	3-isopropylmalate dehydrogenase activity
I8N73_03175	COG1802	Transcriptional regulator
I8N73_03180	COG1819	glycosyl
I8N73_03195	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_03205	COG1388	LysM domain
I8N73_03210	COG2814	Major facilitator Superfamily
I8N73_03215	COG2188	Transcriptional regulator
I8N73_03220	COG2186	Transcriptional regulator
I8N73_03225	COG2807	transmembrane transport
I8N73_03230	COG2076	Multidrug Resistance protein
I8N73_03235	COG2076	Multidrug Resistance protein
I8N73_03240	COG1309	transcriptional regulator
I8N73_03245	COG0531	amino acid
I8N73_03255	COG3832	glyoxalase III activity
I8N73_03260	COG0604	alcohol dehydrogenase
I8N73_03265	COG2814	Major facilitator Superfamily
I8N73_03305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I8N73_03310	COG0802	atpase or kinase
I8N73_03315	COG1214	PFAM Peptidase M22, glycoprotease
I8N73_03320	COG0456	acetyltransferase
I8N73_03325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I8N73_03330	COG0488	(ABC) transporter
I8N73_03345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I8N73_03350	COG0805	protein transport
I8N73_03360	COG1266	CAAX protease self-immunity
I8N73_03375	COG0745	RESPONSE REGULATOR receiver
I8N73_03390	COG3290	protein histidine kinase activity
I8N73_03470	COG0457	Tetratricopeptide repeat
I8N73_03475	COG1063	alcohol dehydrogenase
I8N73_03480	COG2211	Major facilitator Superfamily
I8N73_03485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N73_03495	COG1842	Phage shock protein A
I8N73_03500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N73_03505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I8N73_03510	COG4260	virion core protein, lumpy skin disease virus
I8N73_03515	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I8N73_03515	COG2755	lipolytic protein G-D-S-L family
I8N73_03525	COG1595	DNA-templated transcription, initiation
I8N73_03530	COG1063	alcohol dehydrogenase
I8N73_03535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I8N73_03540	COG0823	Involved in the tonB-independent uptake of proteins
I8N73_03555	COG2132	Multicopper oxidase
I8N73_03560	COG1113	amino acid transport
I8N73_03565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_03570	COG0714	Associated with various cellular activities
I8N73_03575	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I8N73_03580	COG1305	Transglutaminase-like
I8N73_03605	COG2252	PERMEase
I8N73_03610	COG3064	Membrane
I8N73_03630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I8N73_03635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I8N73_03640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I8N73_03645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I8N73_03650	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I8N73_03665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I8N73_03675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I8N73_03680	COG0138	bifunctional purine biosynthesis protein purh
I8N73_03685	COG0151	Belongs to the GarS family
I8N73_03695	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I8N73_03700	COG1470	cell adhesion involved in biofilm formation
I8N73_03705	COG4496	protein, YerC YecD
I8N73_03710	COG0069	glutamate synthase activity
I8N73_03720	COG0210	DNA helicase
I8N73_03730	COG4851	CamS sex pheromone cAM373 precursor
I8N73_03735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N73_03740	COG1285	pathogenesis
I8N73_03745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_03765	COG1309	transcriptional regulator
I8N73_03770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I8N73_03775	COG1597	lipid kinase activity
I8N73_03780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N73_03790	COG1131	(ABC) transporter
I8N73_03810	COG5444	nuclease activity
I8N73_03830	COG5444	nuclease activity
I8N73_03855	COG3546	catalase activity
I8N73_03860	COG0454	-acetyltransferase
I8N73_03870	COG2323	membrane
I8N73_03875	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_03880	COG0346	lactoylglutathione lyase activity
I8N73_03885	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_03890	COG5583	Uncharacterized small protein (DUF2292)
I8N73_03895	COG0196	riboflavin kinase activity
I8N73_03900	COG0670	Belongs to the BI1 family
I8N73_03905	COG1846	Transcriptional regulator
I8N73_03910	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N73_03920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N73_03920	COG2124	cytochrome p450
I8N73_03935	COG1131	(ABC) transporter
I8N73_03945	COG1368	sulfuric ester hydrolase activity
I8N73_03950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I8N73_03955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_03960	COG1442	glycosyl transferase family 8
I8N73_03965	COG1216	Glycosyl transferase, family 2
I8N73_03970	COG1442	glycosyl transferase family 8
I8N73_03975	COG2223	nitrite transmembrane transporter activity
I8N73_03980	COG0531	amino acid
I8N73_03985	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_03990	COG0840	transmembrane signaling receptor activity
I8N73_03995	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_04000	COG0457	Tetratricopeptide repeat
I8N73_04000	COG0463	Glycosyl transferase, family 2
I8N73_04005	COG0488	(ABC) transporter
I8N73_04010	COG0789	Transcriptional regulator
I8N73_04015	COG2814	Major facilitator Superfamily
I8N73_04020	COG0488	(ABC) transporter
I8N73_04025	COG0513	Belongs to the DEAD box helicase family
I8N73_04030	COG0456	acetyltransferase
I8N73_04035	COG2130	NADP-dependent
I8N73_04050	COG3866	Pectate lyase
I8N73_04055	COG0471	metal ion transport
I8N73_04075	COG0745	RESPONSE REGULATOR receiver
I8N73_04075	COG2972	Histidine kinase
I8N73_04080	COG3279	Response regulator of the LytR AlgR family
I8N73_04090	COG3764	Sortase (surface protein transpeptidase)
I8N73_04095	COG3290	protein histidine kinase activity
I8N73_04100	COG4565	transcriptional regulatory protein
I8N73_04105	COG3181	Tripartite tricarboxylate transporter family receptor
I8N73_04110	COG2851	Citrate transporter
I8N73_04115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_04120	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I8N73_04130	COG2258	MOSC domain
I8N73_04150	COG0024	Methionine aminopeptidase
I8N73_04155	COG1263	PTS System
I8N73_04155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_04165	COG1368	sulfuric ester hydrolase activity
I8N73_04175	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_04190	COG1263	PTS System
I8N73_04195	COG0366	Alpha amylase catalytic
I8N73_04200	COG2188	Transcriptional regulator
I8N73_04205	COG0778	Nitroreductase
I8N73_04220	COG0737	Belongs to the 5'-nucleotidase family
I8N73_04225	COG0693	protein deglycase activity
I8N73_04230	COG1609	Transcriptional regulator
I8N73_04245	COG2814	Major facilitator Superfamily
I8N73_04255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N73_04260	COG4980	gas vesicle protein
I8N73_04265	COG1295	ribonuclease BN
I8N73_04270	COG0477	Major facilitator Superfamily
I8N73_04275	COG0387	Pfam Sodium calcium exchanger
I8N73_04285	COG0668	transmembrane transport
I8N73_04290	COG0535	radical SAM domain protein
I8N73_04300	COG0726	polysaccharide deacetylase
I8N73_04305	COG2084	Dehydrogenase
I8N73_04315	COG0598	Magnesium transport protein CorA
I8N73_04320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I8N73_04325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I8N73_04340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I8N73_04345	COG4637	Psort location Cytoplasmic, score
I8N73_04350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N73_04355	COG0022	dehydrogenase e1 component
I8N73_04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_04365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N73_04370	COG3284	Transcriptional regulator
I8N73_04380	COG1486	melibiose metabolic process
I8N73_04385	COG1737	Transcriptional regulator
I8N73_04390	COG1263	PTS System
I8N73_04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_04395	COG1132	(ABC) transporter
I8N73_04400	COG1132	(ABC) transporter
I8N73_04405	COG2259	Doxx family
I8N73_04410	COG2514	catechol 2,3-dioxygenase activity
I8N73_04420	COG1695	Transcriptional regulator
I8N73_04425	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N73_04430	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I8N73_04435	COG3848	Pyruvate phosphate dikinase
I8N73_04435	COG0574	Belongs to the PEP-utilizing enzyme family
I8N73_04440	COG2732	(Barnase) inhibitor
I8N73_04445	COG2318	DinB family
I8N73_04450	COG2814	Major facilitator Superfamily
I8N73_04455	COG1846	Transcriptional regulator
I8N73_04460	COG0392	lysyltransferase activity
I8N73_04460	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I8N73_04465	COG0384	phenazine biosynthesis protein PhzF
I8N73_04470	COG0778	Nitroreductase
I8N73_04485	COG1090	epimerase
I8N73_04500	COG2814	Major facilitator Superfamily
I8N73_04510	COG3591	Belongs to the peptidase S1B family
I8N73_04525	COG3103	Sh3 type 3 domain protein
I8N73_04530	COG5658	integral membrane protein
I8N73_04535	COG0596	Alpha beta hydrolase
I8N73_04540	COG0463	Glycosyl transferase, family 2
I8N73_04545	COG4485	Bacterial membrane protein, YfhO
I8N73_04550	COG1988	membrane-bound metal-dependent
I8N73_04555	COG1194	a g-specific adenine glycosylase
I8N73_04565	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_04585	COG1132	(ABC) transporter
I8N73_04590	COG4129	membrane
I8N73_04600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I8N73_04605	COG0735	belongs to the Fur family
I8N73_04715	COG1757	Na H antiporter
I8N73_04720	COG3340	Belongs to the peptidase S51 family
I8N73_04730	COG0277	FAD linked oxidase domain protein
I8N73_04740	COG0747	negative chemotaxis
I8N73_04745	COG0601	transmembrane transport
I8N73_04750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_04755	COG0444	Belongs to the ABC transporter superfamily
I8N73_04760	COG4608	Belongs to the ABC transporter superfamily
I8N73_04765	COG0753	catalase activity
I8N73_04775	COG1116	anion transmembrane transporter activity
I8N73_04780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N73_04785	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N73_04805	COG1476	TRANSCRIPTIONal
I8N73_04815	COG3382	B3 4 domain protein
I8N73_04820	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I8N73_04830	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I8N73_04835	COG0789	Transcriptional regulator
I8N73_04840	COG1664	Polymer-forming cytoskeletal
I8N73_04845	COG1664	Polymer-forming cytoskeletal
I8N73_04850	COG2766	serine protein kinase
I8N73_04860	COG1846	Transcriptional regulator
I8N73_04865	COG1566	PFAM secretion protein HlyD family protein
I8N73_04870	COG2814	Major facilitator Superfamily
I8N73_04875	COG0655	NAD(P)H dehydrogenase (quinone) activity
I8N73_04890	COG1725	Transcriptional regulator
I8N73_04895	COG1131	(ABC) transporter
I8N73_04900	COG1131	(ABC) transporter
I8N73_04905	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N73_04910	COG1278	Cold shock
I8N73_04915	COG1464	Belongs to the NlpA lipoprotein family
I8N73_04920	COG3706	GGDEF domain
I8N73_04925	COG1823	symporter activity
I8N73_04945	COG5577	PFAM Coat F domain
I8N73_04950	COG0737	Belongs to the 5'-nucleotidase family
I8N73_04950	COG1525	nuclease
I8N73_04950	COG4085	toxin activity
I8N73_04955	COG3764	Sortase (surface protein transpeptidase)
I8N73_04960	COG0564	pseudouridine synthase activity
I8N73_04970	COG0517	IMP dehydrogenase activity
I8N73_04975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I8N73_04980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N73_04980	COG3153	acetyltransferase
I8N73_04985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N73_04990	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I8N73_04995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I8N73_05005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I8N73_05010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I8N73_05015	COG4585	Histidine kinase
I8N73_05015	COG2203	Gaf domain
I8N73_05020	COG2197	response regulator
I8N73_05025	COG0431	NADPH-dependent FMN reductase
I8N73_05040	COG0791	NLP P60 protein
I8N73_05040	COG1388	LysM domain
I8N73_05045	COG1959	2 iron, 2 sulfur cluster binding
I8N73_05050	COG0668	transmembrane transport
I8N73_05055	COG2719	SpoVR family
I8N73_05060	COG1785	Belongs to the alkaline phosphatase family
I8N73_05065	COG0791	NLP P60 protein
I8N73_05065	COG1388	LysM domain
I8N73_05070	COG0583	DNA-binding transcription factor activity
I8N73_05075	COG0372	Belongs to the citrate synthase family
I8N73_05080	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_05085	COG0531	amino acid
I8N73_05090	COG0733	neurotransmitter:sodium symporter activity
I8N73_05105	COG1595	DNA-templated transcription, initiation
I8N73_05110	COG0204	Acyl-transferase
I8N73_05115	COG1253	flavin adenine dinucleotide binding
I8N73_05120	COG0789	Transcriptional regulator
I8N73_05125	COG0436	Aminotransferase
I8N73_05130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N73_05135	COG1253	flavin adenine dinucleotide binding
I8N73_05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N73_05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I8N73_05150	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_05160	COG0668	transmembrane transport
I8N73_05165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I8N73_05170	COG0726	polysaccharide deacetylase
I8N73_05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_05180	COG3226	Transcriptional regulator
I8N73_05190	COG0589	response to stress
I8N73_05195	COG1132	(ABC) transporter
I8N73_05200	COG1132	(ABC) transporter
I8N73_05205	COG0702	epimerase
I8N73_05220	COG0189	ligase activity
I8N73_05225	COG0189	ligase activity
I8N73_05240	COG4335	DNA alkylation repair
I8N73_05245	COG0561	phosphatase activity
I8N73_05250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N73_05260	COG0475	glutathione-regulated potassium exporter activity
I8N73_05265	COG0490	domain, Protein
I8N73_05275	COG1024	Enoyl-CoA hydratase
I8N73_05285	COG4152	abc transporter atp-binding protein
I8N73_05290	COG1668	transmembrane transport
I8N73_05295	COG0420	3'-5' exonuclease activity
I8N73_05300	COG4717	serine-type aminopeptidase activity
I8N73_05315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I8N73_05350	COG4980	gas vesicle protein
I8N73_05365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I8N73_05370	COG0537	adenosine 5'-monophosphoramidase activity
I8N73_05375	COG1131	(ABC) transporter
I8N73_05380	COG4473	ABC transporter
I8N73_05390	COG1473	amidohydrolase
I8N73_05395	COG3069	C4-dicarboxylate transmembrane transporter activity
I8N73_05400	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_05405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_05415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I8N73_05425	COG1309	transcriptional regulator
I8N73_05430	COG1511	domain protein
I8N73_05435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N73_05445	COG1363	Peptidase, m42
I8N73_05450	COG1301	dicarboxylic acid transport
I8N73_05460	COG1234	tRNA 3'-trailer cleavage
I8N73_05465	COG0095	Lipoate-protein ligase
I8N73_05470	COG0702	epimerase
I8N73_05475	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_05485	COG0501	Belongs to the peptidase M48B family
I8N73_05490	COG1404	Belongs to the peptidase S8 family
I8N73_05495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I8N73_05500	COG0406	alpha-ribazole phosphatase activity
I8N73_05505	COG0183	Belongs to the thiolase family
I8N73_05510	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_05515	COG1268	BioY protein
I8N73_05520	COG0840	transmembrane signaling receptor activity
I8N73_05525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N73_05525	COG0723	plastoquinol--plastocyanin reductase activity
I8N73_05530	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_05540	COG4903	ComK protein
I8N73_05550	COG5646	InterPro IPR014922
I8N73_05575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_05590	COG0398	Pfam SNARE associated Golgi protein
I8N73_05595	COG0681	Belongs to the peptidase S26 family
I8N73_05600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I8N73_05605	COG1846	Transcriptional regulator
I8N73_05610	COG3180	Ammonia monooxygenase
I8N73_05615	COG2814	Major facilitator Superfamily
I8N73_05625	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I8N73_05630	COG2323	membrane
I8N73_05645	COG0420	3'-5' exonuclease activity
I8N73_05650	COG0419	ATPase involved in DNA repair
I8N73_05655	COG1403	HNH endonuclease
I8N73_05695	COG0179	Fumarylacetoacetate (FAA) hydrolase
I8N73_05715	COG0367	asparagine synthase
I8N73_05720	COG1562	ergosterol biosynthetic process
I8N73_05725	COG0534	Mate efflux family protein
I8N73_05730	COG2207	Transcriptional regulator
I8N73_05730	COG1917	Cupin 2, conserved barrel domain protein
I8N73_05735	COG2318	DinB family
I8N73_05740	COG1357	PFAM Pentapeptide repeats (8 copies)
I8N73_05745	COG2153	protein acetylation
I8N73_05750	COG0646	methionine synthase
I8N73_05750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I8N73_05760	COG2996	Protein conserved in bacteria
I8N73_05765	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N73_05770	COG0840	transmembrane signaling receptor activity
I8N73_05775	COG2124	cytochrome p450
I8N73_05785	COG1307	EDD domain protein, DegV family
I8N73_05790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_05810	COG0561	phosphatase activity
I8N73_05815	COG1073	alpha beta
I8N73_05820	COG2151	metal-sulfur cluster biosynthetic enzyme
I8N73_05830	COG0277	FAD linked oxidase domain protein
I8N73_05835	COG2271	Major facilitator Superfamily
I8N73_05845	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I8N73_05855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N73_05860	COG0505	Belongs to the CarA family
I8N73_05865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N73_05870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I8N73_05885	COG2267	carboxylic ester hydrolase activity
I8N73_05895	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N73_05910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N73_05915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I8N73_05920	COG5504	Zn-dependent protease
I8N73_05925	COG0444	Belongs to the ABC transporter superfamily
I8N73_05930	COG4608	Belongs to the ABC transporter superfamily
I8N73_05940	COG0601	transmembrane transport
I8N73_05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_05960	COG0180	Tryptophanyl-tRNA synthetase
I8N73_05965	COG4166	transmembrane transport
I8N73_05970	COG0601	transmembrane transport
I8N73_05975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_05980	COG0444	Belongs to the ABC transporter superfamily
I8N73_05985	COG4608	Belongs to the ABC transporter superfamily
I8N73_05995	COG0456	acetyltransferase
I8N73_06000	COG1393	Belongs to the ArsC family
I8N73_06005	COG0861	Integral membrane protein TerC family
I8N73_06015	COG4862	establishment of competence for transformation
I8N73_06020	COG4469	Competence protein
I8N73_06025	COG1164	Oligoendopeptidase f
I8N73_06035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N73_06040	COG2346	COG2346, Truncated hemoglobins
I8N73_06045	COG0741	lytic transglycosylase activity
I8N73_06050	COG4116	CYTH
I8N73_06060	COG2357	RelA SpoT domain protein
I8N73_06065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N73_06070	COG0564	pseudouridine synthase activity
I8N73_06080	COG0569	domain protein
I8N73_06080	COG0475	glutathione-regulated potassium exporter activity
I8N73_06085	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I8N73_06090	COG0352	thiamine-phosphate diphosphorylase activity
I8N73_06095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N73_06100	COG2104	thiamine diphosphate biosynthetic process
I8N73_06110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N73_06115	COG0351	phosphomethylpyrimidine kinase
I8N73_06120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I8N73_06175	COG0210	DNA helicase
I8N73_06195	COG1131	(ABC) transporter
I8N73_06205	COG2153	protein acetylation
I8N73_06215	COG2382	esterase
I8N73_06220	COG0626	cystathionine gamma-synthase activity
I8N73_06225	COG0626	cystathionine gamma-synthase activity
I8N73_06255	COG5444	nuclease activity
I8N73_06295	COG0135	phosphoribosylanthranilate isomerase activity
I8N73_06305	COG2367	Beta-lactamase
I8N73_06310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I8N73_06320	COG1846	Transcriptional regulator
I8N73_06330	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I8N73_06335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8N73_06340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8N73_06345	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_06345	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_06350	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N73_06375	COG1285	pathogenesis
I8N73_06390	COG2205	protein histidine kinase activity
I8N73_06400	COG3383	formate dehydrogenase (NAD+) activity
I8N73_06405	COG2427	Protein of unknown function (DUF1641)
I8N73_06410	COG2124	cytochrome p450
I8N73_06415	COG1819	glycosyl
I8N73_06425	COG1587	Uroporphyrinogen-III synthase
I8N73_06430	COG0390	transport system, permease component
I8N73_06435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N73_06440	COG0697	spore germination
I8N73_06445	COG4297	protein containing double-stranded beta helix domain
I8N73_06455	COG1252	NADH dehydrogenase
I8N73_06465	COG2211	Major facilitator Superfamily
I8N73_06470	COG1609	Transcriptional regulator
I8N73_06475	COG0246	Mannitol dehydrogenase
I8N73_06480	COG2721	sulfolactate sulfo-lyase activity
I8N73_06485	COG0745	RESPONSE REGULATOR receiver
I8N73_06490	COG2770	Histidine kinase
I8N73_06490	COG2205	protein histidine kinase activity
I8N73_06505	COG0730	response to heat
I8N73_06510	COG2318	DinB family
I8N73_06515	COG0457	Tetratricopeptide repeat
I8N73_06525	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_06525	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_06525	COG1388	LysM domain
I8N73_06535	COG4195	phage-related replication protein
I8N73_06545	COG2856	Zn peptidase
I8N73_06550	COG1396	sequence-specific DNA binding
I8N73_06560	COG1522	sequence-specific DNA binding
I8N73_06565	COG1484	DNA-dependent DNA replication
I8N73_06585	COG1595	DNA-templated transcription, initiation
I8N73_06590	COG5484	DNA packaging
I8N73_06590	COG3728	DNA packaging
I8N73_06595	COG1783	phage Terminase large subunit
I8N73_06600	COG5518	Phage portal protein
I8N73_06605	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I8N73_06610	COG4653	Phage capsid family
I8N73_06660	COG5412	phage tail tape measure protein
I8N73_06660	COG3953	SLT domain
I8N73_06660	COG5412	phage tail tape measure protein
I8N73_06660	COG3953	SLT domain
I8N73_06660	COG5412	phage tail tape measure protein
I8N73_06660	COG3953	SLT domain
I8N73_06665	COG1652	LysM domain
I8N73_06670	COG4193	domain, Protein
I8N73_06680	COG3628	GPW Gp25 family protein
I8N73_06685	COG3299	homolog of phage Mu protein gp47
I8N73_06690	COG3778	Protein conserved in bacteria
I8N73_06730	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_06730	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_06745	COG0306	phosphate transporter
I8N73_06750	COG1392	Phosphate transport regulator
I8N73_06755	COG0531	amino acid
I8N73_06760	COG0346	lactoylglutathione lyase activity
I8N73_06765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8N73_06770	COG0463	Glycosyl transferase, family 2
I8N73_06780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_06785	COG0477	Major facilitator Superfamily
I8N73_06790	COG2362	D-Aminopeptidase
I8N73_06795	COG0601	transmembrane transport
I8N73_06800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I8N73_06805	COG0444	Belongs to the ABC transporter superfamily
I8N73_06810	COG4166	transmembrane transport
I8N73_06815	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N73_06820	COG4948	Mandelate Racemase Muconate Lactonizing
I8N73_06825	COG0791	NLP P60 protein
I8N73_06830	COG4608	Belongs to the ABC transporter superfamily
I8N73_06835	COG2706	6-phosphogluconolactonase activity
I8N73_06840	COG1834	amidinotransferase
I8N73_06845	COG1607	acyl-coa hydrolase
I8N73_06850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_06855	COG2076	Multidrug Resistance protein
I8N73_06860	COG2076	Multidrug Resistance protein
I8N73_06865	COG0788	formyltetrahydrofolate deformylase activity
I8N73_06870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N73_06880	COG1764	response to oxidative stress
I8N73_06885	COG1846	Transcriptional regulator
I8N73_06890	COG1764	response to oxidative stress
I8N73_06905	COG0463	Glycosyl transferase, family 2
I8N73_06905	COG0457	Tetratricopeptide repeat
I8N73_06915	COG2814	Major facilitator Superfamily
I8N73_06920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N73_06930	COG1404	Belongs to the peptidase S8 family
I8N73_06935	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_06940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I8N73_06945	COG1122	ATPase activity
I8N73_06950	COG4721	ABC-type cobalt transport system, permease component
I8N73_06955	COG1388	LysM domain
I8N73_06955	COG3858	chitin binding
I8N73_06965	COG2239	Acts as a magnesium transporter
I8N73_06970	COG0789	Transcriptional regulator
I8N73_06985	COG1846	Transcriptional regulator
I8N73_06990	COG0726	polysaccharide deacetylase
I8N73_06995	COG1793	dna ligase
I8N73_06995	COG3285	dna ligase
I8N73_07000	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I8N73_07005	COG0586	Pfam SNARE associated Golgi protein
I8N73_07010	COG0861	Integral membrane protein TerC family
I8N73_07015	COG1191	sigma factor activity
I8N73_07040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I8N73_07045	COG2323	membrane
I8N73_07055	COG3594	Acyltransferase
I8N73_07060	COG5002	protein histidine kinase activity
I8N73_07065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N73_07080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I8N73_07085	COG0436	Aminotransferase
I8N73_07115	COG3852	Histidine kinase
I8N73_07120	COG1846	Transcriptional regulator
I8N73_07125	COG1360	Flagellar Motor Protein
I8N73_07130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N73_07135	COG0542	response to heat
I8N73_07140	COG3949	Membrane
I8N73_07155	COG0720	synthase
I8N73_07160	COG0602	queuosine metabolic process
I8N73_07170	COG1733	regulation of RNA biosynthetic process
I8N73_07175	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_07185	COG4641	Protein conserved in bacteria
I8N73_07185	COG1388	LysM domain
I8N73_07190	COG1388	LysM domain
I8N73_07195	COG3858	chitin binding
I8N73_07205	COG4873	Protein conserved in bacteria
I8N73_07215	COG3773	Cell wall hydrolase
I8N73_07220	COG2244	polysaccharide biosynthetic process
I8N73_07225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_07230	COG2217	Heavy metal translocating P-type atpase
I8N73_07235	COG0006	proline dipeptidase activity
I8N73_07240	COG1609	Transcriptional regulator
I8N73_07245	COG3711	transcriptional antiterminator
I8N73_07250	COG2190	(PTS) system
I8N73_07250	COG1263	PTS System
I8N73_07250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_07255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_07260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I8N73_07270	COG1533	DNA photolyase activity
I8N73_07275	COG0840	transmembrane signaling receptor activity
I8N73_07280	COG2084	Dehydrogenase
I8N73_07285	COG2340	Cysteine-rich secretory protein family
I8N73_07290	COG0768	penicillin binding
I8N73_07295	COG4191	Histidine kinase
I8N73_07300	COG0436	Aminotransferase
I8N73_07310	COG0835	chemotaxis
I8N73_07310	COG0784	Response regulator, receiver
I8N73_07320	COG2814	Major facilitator Superfamily
I8N73_07325	COG1376	ErfK ybiS ycfS ynhG family protein
I8N73_07330	COG1408	metallophosphoesterase
I8N73_07335	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_07345	COG2200	EAL domain
I8N73_07350	COG4703	Protein of unknown function (DUF1797)
I8N73_07355	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I8N73_07365	COG0517	IMP dehydrogenase activity
I8N73_07370	COG0583	DNA-binding transcription factor activity
I8N73_07375	COG0716	FMN binding
I8N73_07385	COG0716	FMN binding
I8N73_07405	COG0668	transmembrane transport
I8N73_07410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_07430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N73_07435	COG0303	'Molybdopterin
I8N73_07440	COG1763	Mo-molybdopterin cofactor biosynthetic process
I8N73_07445	COG0314	molybdopterin synthase activity
I8N73_07450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I8N73_07460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I8N73_07465	COG1136	(ABC) transporter
I8N73_07470	COG0577	efflux transmembrane transporter activity
I8N73_07475	COG1349	DNA-binding transcription factor activity
I8N73_07480	COG1105	Belongs to the carbohydrate kinase PfkB family
I8N73_07485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_07485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_07485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_07490	COG0681	Belongs to the peptidase S26 family
I8N73_07500	COG0488	(ABC) transporter
I8N73_07505	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N73_07510	COG2309	aminopeptidase activity
I8N73_07520	COG1077	Cell shape determining protein MreB Mrl
I8N73_07525	COG2002	toxin-antitoxin pair type II binding
I8N73_07530	COG3852	Histidine kinase
I8N73_07535	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I8N73_07535	COG2105	PFAM AIG2 family protein
I8N73_07540	COG0569	domain protein
I8N73_07550	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N73_07560	COG0561	phosphatase activity
I8N73_07565	COG0242	peptide deformylase activity
I8N73_07575	COG0497	DNA recombination
I8N73_07585	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_07585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_07585	COG4221	oxidoreductase activity
I8N73_07585	COG3321	synthase
I8N73_07590	COG3321	synthase
I8N73_07590	COG0300	oxidoreductase activity
I8N73_07590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_07590	COG4221	oxidoreductase activity
I8N73_07595	COG4221	oxidoreductase activity
I8N73_07595	COG3321	synthase
I8N73_07595	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_07595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_07600	COG0300	oxidoreductase activity
I8N73_07600	COG3321	synthase
I8N73_07600	COG4221	oxidoreductase activity
I8N73_07600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_07605	COG0300	oxidoreductase activity
I8N73_07605	COG3321	synthase
I8N73_07605	COG4221	oxidoreductase activity
I8N73_07605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_07610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_07610	COG0300	oxidoreductase activity
I8N73_07610	COG3321	synthase
I8N73_07610	COG4221	oxidoreductase activity
I8N73_07615	COG4221	oxidoreductase activity
I8N73_07615	COG3321	synthase
I8N73_07615	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_07615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_07620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_07625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N73_07630	COG0022	dehydrogenase e1 component
I8N73_07635	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N73_07645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_07660	COG1982	Orn Lys Arg decarboxylase major
I8N73_07680	COG0483	inositol monophosphate 1-phosphatase activity
I8N73_07690	COG3227	Zinc metalloprotease (Elastase)
I8N73_07715	COG1217	gtp-binding protein TYPA
I8N73_07725	COG4896	Protein conserved in bacteria
I8N73_07735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I8N73_07740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N73_07745	COG2066	Belongs to the glutaminase family
I8N73_07755	COG0772	Belongs to the SEDS family
I8N73_07760	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I8N73_07775	COG2010	Cytochrome c
I8N73_07775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N73_07780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N73_07785	COG1845	cytochrome c oxidase, subunit III
I8N73_07790	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I8N73_07795	COG3336	cytochrome c oxidase
I8N73_07805	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I8N73_07810	COG2340	Cysteine-rich secretory protein family
I8N73_07825	COG3679	Belongs to the UPF0342 family
I8N73_07840	COG0742	ribosomal rna small subunit methyltransferase
I8N73_07850	COG3314	Sporulation integral membrane protein YlbJ
I8N73_07855	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N73_07860	COG3480	Lon protease (S16) C-terminal proteolytic domain
I8N73_07870	COG1399	metal-binding, possibly nucleic acid-binding protein
I8N73_07890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I8N73_07910	COG4839	cell division protein FtsL
I8N73_07915	COG0768	penicillin binding
I8N73_07920	COG0768	penicillin binding
I8N73_07940	COG0772	Belongs to the SEDS family
I8N73_07955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I8N73_07960	COG0849	cell division
I8N73_07965	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I8N73_07970	COG1404	Belongs to the peptidase S8 family
I8N73_07970	COG4412	M6 family metalloprotease domain protein
I8N73_07980	COG1191	sigma factor activity
I8N73_07985	COG1191	sigma factor activity
I8N73_07990	COG1119	ATPase activity
I8N73_07995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_08000	COG1873	PFAM PRC-barrel domain
I8N73_08005	COG1496	oxidoreductase activity
I8N73_08010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I8N73_08020	COG0762	integral membrane protein
I8N73_08025	COG2302	S4 RNA-binding domain
I8N73_08030	COG3599	regulation of cell shape
I8N73_08035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I8N73_08040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N73_08050	COG0564	pseudouridine synthase activity
I8N73_08060	COG2233	PERMEase
I8N73_08070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I8N73_08075	COG0505	Belongs to the CarA family
I8N73_08080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I8N73_08095	COG0284	orotidine-5'-phosphate decarboxylase activity
I8N73_08100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I8N73_08110	COG0306	phosphate transporter
I8N73_08125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I8N73_08130	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I8N73_08135	COG1648	precorrin-2 dehydrogenase activity
I8N73_08145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I8N73_08150	COG1561	YicC-like family, N-terminal region
I8N73_08160	COG0194	GDP metabolic process
I8N73_08170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N73_08175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I8N73_08180	COG0242	peptide deformylase activity
I8N73_08190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I8N73_08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I8N73_08200	COG0631	protein serine/threonine phosphatase activity
I8N73_08205	COG2815	serine threonine protein kinase
I8N73_08205	COG0515	serine threonine protein kinase
I8N73_08215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I8N73_08220	COG1564	THIamine pyrophosphokinase
I8N73_08235	COG1302	Protein conserved in bacteria
I8N73_08240	COG1461	Dihydroxyacetone kinase
I8N73_08245	COG1760	l-serine dehydratase
I8N73_08250	COG1760	l-serine dehydratase
I8N73_08255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I8N73_08270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N73_08275	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_08290	COG1196	nuclear chromosome segregation
I8N73_08295	COG0552	protein localization to endoplasmic reticulum
I8N73_08310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I8N73_08320	COG1837	Belongs to the UPF0109 family
I8N73_08345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N73_08360	COG2257	FlhB HrpN YscU SpaS Family
I8N73_08370	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I8N73_08375	COG0758	DNA mediated transformation
I8N73_08380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I8N73_08390	COG4974	Belongs to the 'phage' integrase family
I8N73_08410	COG1815	bacterial-type flagellum-dependent cell motility
I8N73_08415	COG1558	bacterial-type flagellum-dependent cell motility
I8N73_08420	COG1677	Flagellar hook-basal body complex protein FliE
I8N73_08425	COG1766	The M ring may be actively involved in energy transduction
I8N73_08430	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N73_08435	COG1317	bacterial-type flagellum organization
I8N73_08440	COG1157	protein secretion by the type III secretion system
I8N73_08445	COG2882	bacterial-type flagellum organization
I8N73_08450	COG3334	PFAM MgtE intracellular
I8N73_08455	COG3144	bacterial-type flagellum assembly
I8N73_08460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I8N73_08465	COG4786	Flagellar basal body rod
I8N73_08470	COG1582	Flagellar protein (FlbD)
I8N73_08475	COG1580	Controls the rotational direction of flagella during chemotaxis
I8N73_08480	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N73_08485	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I8N73_08485	COG1776	CheC inhibitor of MCP methylation
I8N73_08490	COG2201	protein-glutamate methylesterase activity
I8N73_08495	COG3190	flagellar
I8N73_08500	COG1338	Plays a role in the flagellum-specific transport system
I8N73_08505	COG1987	bacterial-type flagellum assembly
I8N73_08510	COG1684	flagellar biosynthetic protein fliR
I8N73_08515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N73_08520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I8N73_08525	COG1419	protein localization to endoplasmic reticulum
I8N73_08530	COG0455	bacterial-type flagellum organization
I8N73_08535	COG2201	protein-glutamate methylesterase activity
I8N73_08540	COG2198	Histidine kinase
I8N73_08540	COG0643	Histidine kinase
I8N73_08545	COG0835	chemotaxis
I8N73_08550	COG1776	CheC inhibitor of MCP methylation
I8N73_08560	COG1191	sigma factor activity
I8N73_08590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I8N73_08595	COG4589	Belongs to the CDS family
I8N73_08605	COG0750	zinc metalloprotease
I8N73_08615	COG2176	DNA-directed DNA polymerase activity
I8N73_08625	COG0195	Participates in both transcription termination and antitermination
I8N73_08630	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I8N73_08635	COG1358	cellular component organization or biogenesis
I8N73_08645	COG1550	Protein conserved in bacteria
I8N73_08660	COG0196	riboflavin kinase activity
I8N73_08675	COG0726	polysaccharide deacetylase
I8N73_08680	COG0612	Peptidase, M16
I8N73_08685	COG1873	PFAM PRC-barrel domain
I8N73_08690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N73_08695	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I8N73_08700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I8N73_08705	COG0527	aspartate kinase activity
I8N73_08715	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I8N73_08720	COG0740	serine-type endopeptidase activity
I8N73_08730	COG1674	ftsk spoiiie
I8N73_08730	COG4980	gas vesicle protein
I8N73_08735	COG2188	Transcriptional regulator
I8N73_08740	COG2814	Major facilitator Superfamily
I8N73_08745	COG1846	Transcriptional regulator
I8N73_08750	COG2409	Drug exporters of the RND superfamily
I8N73_08750	COG1033	growth of symbiont in host cell
I8N73_08755	COG0612	Peptidase, M16
I8N73_08760	COG0612	Peptidase, M16
I8N73_08765	COG0300	oxidoreductase activity
I8N73_08780	COG1426	Protein conserved in bacteria
I8N73_08785	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I8N73_08800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I8N73_08810	COG1692	metallophosphoesterase
I8N73_08815	COG2359	stage V sporulation protein S
I8N73_08835	COG4550	Control of competence regulator ComK, YlbF/YmcA
I8N73_08900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_08905	COG3425	synthase
I8N73_08910	COG1024	Enoyl-CoA hydratase
I8N73_08915	COG1024	Enoyl-CoA hydratase
I8N73_08920	COG0300	oxidoreductase activity
I8N73_08920	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_08920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_08920	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_08920	COG3321	synthase
I8N73_08925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_08925	COG4221	oxidoreductase activity
I8N73_08925	COG3321	synthase
I8N73_08925	COG0300	oxidoreductase activity
I8N73_08930	COG3321	synthase
I8N73_08930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_08930	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_08930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_08930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_08930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_08930	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_08930	COG3321	synthase
I8N73_08930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_08930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_08935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_08935	COG3321	synthase
I8N73_08935	COG4221	oxidoreductase activity
I8N73_08935	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_08940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I8N73_08940	COG3321	synthase
I8N73_08940	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N73_08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_08945	COG2124	cytochrome p450
I8N73_08950	COG3209	COG3209 Rhs family protein
I8N73_08955	COG3619	membrane
I8N73_08980	COG4195	phage-related replication protein
I8N73_08985	COG1764	response to oxidative stress
I8N73_08995	COG2076	Multidrug Resistance protein
I8N73_09035	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_09040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_09045	COG4112	unkown
I8N73_09050	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_09060	COG1525	nuclease
I8N73_09065	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_09075	COG5444	nuclease activity
I8N73_09120	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N73_09125	COG0457	Tetratricopeptide repeat
I8N73_09145	COG5632	N-Acetylmuramoyl-L-alanine amidase
I8N73_09145	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_09150	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_09170	COG2433	Pfam Transposase IS66
I8N73_09180	COG0741	lytic transglycosylase activity
I8N73_09180	COG0739	heme binding
I8N73_09180	COG1196	nuclear chromosome segregation
I8N73_09195	COG0582	viral genome integration into host DNA
I8N73_09295	COG4373	Mu-like prophage FluMu protein gp28
I8N73_09340	COG0776	regulation of translation
I8N73_09420	COG3655	Transcriptional regulator
I8N73_09540	COG3655	Transcriptional regulator
I8N73_09615	COG3646	Phage regulatory protein
I8N73_09615	COG3645	SOS response
I8N73_09625	COG1793	dna ligase
I8N73_09630	COG2135	peptidase activity
I8N73_09650	COG4195	phage-related replication protein
I8N73_09655	COG3420	alginic acid biosynthetic process
I8N73_09655	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_09705	COG3584	3D domain protein
I8N73_09720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I8N73_09725	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I8N73_09800	COG1780	Probably involved in ribonucleotide reductase function
I8N73_09805	COG1372	Participates in initiation and elongation during chromosome replication
I8N73_09805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_09815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I8N73_09820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_09830	COG0756	dUTP diphosphatase activity
I8N73_09850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I8N73_09855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N73_09890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N73_09925	COG3331	DNA recombination
I8N73_09940	COG0464	growth
I8N73_09945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I8N73_09950	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I8N73_09955	COG0789	Transcriptional regulator
I8N73_09960	COG0174	glutamine synthetase
I8N73_09970	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_09995	COG2211	Major facilitator Superfamily
I8N73_10000	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_10015	COG1070	Carbohydrate kinase
I8N73_10020	COG0574	Belongs to the PEP-utilizing enzyme family
I8N73_10020	COG3848	Pyruvate phosphate dikinase
I8N73_10040	COG1064	alcohol dehydrogenase
I8N73_10060	COG0456	acetyltransferase
I8N73_10085	COG3397	chitin binding
I8N73_10095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_10110	COG5434	Belongs to the glycosyl hydrolase 28 family
I8N73_10115	COG0756	dUTP diphosphatase activity
I8N73_10120	COG4195	phage-related replication protein
I8N73_10155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N73_10165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I8N73_10185	COG0785	Cytochrome C biogenesis protein
I8N73_10190	COG2201	protein-glutamate methylesterase activity
I8N73_10195	COG4846	Membrane protein involved in cytochrome C biogenesis
I8N73_10205	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_10220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I8N73_10225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_10245	COG0824	Thioesterase
I8N73_10255	COG4841	protein insertion into membrane
I8N73_10265	COG1832	CoA-binding protein
I8N73_10270	COG0187	DNA topoisomerase II activity
I8N73_10275	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I8N73_10285	COG1115	amino acid carrier protein
I8N73_10295	COG1063	alcohol dehydrogenase
I8N73_10300	COG0800	Aldolase
I8N73_10305	COG1312	Catalyzes the dehydration of D-mannonate
I8N73_10310	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_10315	COG1609	Transcriptional regulator
I8N73_10320	COG2271	Major facilitator Superfamily
I8N73_10360	COG0457	Tetratricopeptide repeat
I8N73_10390	COG0577	efflux transmembrane transporter activity
I8N73_10390	COG1136	(ABC) transporter
I8N73_10420	COG2205	protein histidine kinase activity
I8N73_10425	COG0745	RESPONSE REGULATOR receiver
I8N73_10435	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_10460	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_10465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N73_10470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N73_10475	COG2610	gluconate transmembrane transporter activity
I8N73_10480	COG2124	cytochrome p450
I8N73_10500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N73_10510	COG2246	polysaccharide biosynthetic process
I8N73_10515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N73_10520	COG0586	Pfam SNARE associated Golgi protein
I8N73_10525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N73_10530	COG1024	Enoyl-CoA hydratase
I8N73_10535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I8N73_10540	COG0511	ligase activity, forming carbon-carbon bonds
I8N73_10545	COG0439	Biotin carboxylase
I8N73_10550	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_10555	COG1960	acyl-CoA dehydrogenase activity
I8N73_10560	COG1649	PFAM Uncharacterised BCR, COG1649
I8N73_10570	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I8N73_10570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_10575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_10580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_10585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_10590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_10595	COG2027	D-alanyl-D-alanine carboxypeptidase
I8N73_10600	COG2017	converts alpha-aldose to the beta-anomer
I8N73_10605	COG0534	Mate efflux family protein
I8N73_10620	COG0582	viral genome integration into host DNA
I8N73_10625	COG0166	Belongs to the GPI family
I8N73_10630	COG0405	Gamma-glutamyltransferase
I8N73_10635	COG2814	Major facilitator Superfamily
I8N73_10640	COG0640	Transcriptional regulator
I8N73_10645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I8N73_10655	COG0604	alcohol dehydrogenase
I8N73_10660	COG0493	'glutamate synthase
I8N73_10665	COG0070	glutamate synthase
I8N73_10665	COG0069	glutamate synthase activity
I8N73_10665	COG0067	glutamate synthase
I8N73_10670	COG0583	DNA-binding transcription factor activity
I8N73_10675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I8N73_10690	COG0300	oxidoreductase activity
I8N73_10695	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N73_10705	COG2814	Major facilitator Superfamily
I8N73_10710	COG1070	Carbohydrate kinase
I8N73_10715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N73_10720	COG0243	molybdopterin cofactor binding
I8N73_10745	COG5444	nuclease activity
I8N73_10750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_10760	COG1309	transcriptional regulator
I8N73_10765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_10775	COG0640	Transcriptional regulator
I8N73_10780	COG0741	lytic transglycosylase activity
I8N73_10785	COG2322	membrane
I8N73_10800	COG1619	proteins homologs of microcin C7 resistance protein MccF
I8N73_10810	COG3584	3D domain protein
I8N73_10810	COG1388	LysM domain
I8N73_10815	COG0514	ATP-dependent DNA helicase (RecQ)
I8N73_10825	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I8N73_10830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N73_10845	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_10875	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_10880	COG1657	PFAM Prenyltransferase squalene oxidase
I8N73_10885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N73_10890	COG0733	neurotransmitter:sodium symporter activity
I8N73_10895	COG0385	Bile acid
I8N73_10900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_10905	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_10915	COG4548	von Willebrand factor, type A
I8N73_10920	COG0714	Associated with various cellular activities
I8N73_10925	COG2032	superoxide dismutase activity
I8N73_10930	COG0791	NLP P60 protein
I8N73_10930	COG1388	LysM domain
I8N73_10935	COG1819	glycosyl
I8N73_10940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I8N73_10945	COG0534	Mate efflux family protein
I8N73_10950	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_10955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_10960	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_10970	COG2962	Rard protein
I8N73_10985	COG1942	4-Oxalocrotonate Tautomerase
I8N73_10995	COG1733	regulation of RNA biosynthetic process
I8N73_11000	COG0778	Nitroreductase
I8N73_11005	COG0400	carboxylic ester hydrolase activity
I8N73_11010	COG0346	lactoylglutathione lyase activity
I8N73_11020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I8N73_11030	COG2723	6-phospho-beta-galactosidase activity
I8N73_11035	COG2188	Transcriptional regulator
I8N73_11040	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_11040	COG0793	Belongs to the peptidase S41A family
I8N73_11045	COG2226	methyltransferase
I8N73_11055	COG1876	peptidase activity
I8N73_11075	COG0671	phosphoesterase, PA-phosphatase related
I8N73_11105	COG1509	lysine 2,3-aminomutase activity
I8N73_11110	COG0456	acetyltransferase
I8N73_11115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_11120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I8N73_11125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I8N73_11130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I8N73_11135	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I8N73_11145	COG0456	acetyltransferase
I8N73_11150	COG0463	Glycosyl transferase, family 2
I8N73_11165	COG4641	Protein conserved in bacteria
I8N73_11175	COG1086	Polysaccharide biosynthesis protein
I8N73_11220	COG1388	LysM domain
I8N73_11225	COG0457	Tetratricopeptide repeat
I8N73_11235	COG3391	amine dehydrogenase activity
I8N73_11250	COG5444	nuclease activity
I8N73_11255	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_11260	COG1525	nuclease
I8N73_11265	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I8N73_11285	COG1846	Transcriptional regulator
I8N73_11290	COG4698	Protein conserved in bacteria
I8N73_11295	COG2755	lipolytic protein G-D-S-L family
I8N73_11300	COG1999	signal sequence binding
I8N73_11310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I8N73_11315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I8N73_11320	COG1272	protein, Hemolysin III
I8N73_11325	COG0204	Acyl-transferase
I8N73_11330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N73_11345	COG2136	Putative SAM-dependent methyltransferase
I8N73_11345	COG2521	methyltransferase
I8N73_11360	COG1413	lyase activity
I8N73_11370	COG0386	Belongs to the glutathione peroxidase family
I8N73_11380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I8N73_11390	COG1278	Cold shock
I8N73_11410	COG0328	RNA-DNA hybrid ribonuclease activity
I8N73_11415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I8N73_11420	COG0328	RNA-DNA hybrid ribonuclease activity
I8N73_11430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N73_11445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N73_11455	COG1755	Isoprenylcysteine carboxyl methyltransferase
I8N73_11460	COG3424	synthase
I8N73_11485	COG1335	isochorismatase
I8N73_11495	COG2233	PERMEase
I8N73_11505	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I8N73_11510	COG1199	ATP-dependent helicase activity
I8N73_11525	COG0116	Belongs to the methyltransferase superfamily
I8N73_11555	COG3359	exonuclease
I8N73_11560	COG1205	dead DEAH box helicase
I8N73_11560	COG1111	helicase
I8N73_11565	COG2190	(PTS) system
I8N73_11570	COG0071	Belongs to the small heat shock protein (HSP20) family
I8N73_11610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_11610	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N73_11620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I8N73_11625	COG3935	DnaD domain protein
I8N73_11635	COG0436	Aminotransferase
I8N73_11640	COG5353	protein conserved in bacteria
I8N73_11650	COG1199	ATP-dependent helicase activity
I8N73_11650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I8N73_11680	COG0438	transferase activity, transferring glycosyl groups
I8N73_11685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_11700	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N73_11705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_11710	COG2140	Oxalate decarboxylase
I8N73_11720	COG4347	Protein of unknown function (DUF1405)
I8N73_11725	COG2010	Cytochrome c
I8N73_11725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N73_11730	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I8N73_11735	COG0723	plastoquinol--plastocyanin reductase activity
I8N73_11750	COG0457	Tetratricopeptide repeat
I8N73_11765	COG0287	Prephenate dehydrogenase
I8N73_11800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I8N73_11805	COG4401	Chorismate mutase type I
I8N73_11820	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I8N73_11825	COG0105	UTP biosynthetic process
I8N73_11830	COG0142	geranyltranstransferase activity
I8N73_11840	COG0142	geranyltranstransferase activity
I8N73_11855	COG0776	regulation of translation
I8N73_11860	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I8N73_11900	COG0539	negative regulation of cytoplasmic translation
I8N73_11915	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I8N73_11920	COG2959	enzyme of heme biosynthesis
I8N73_11925	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_11925	COG3773	Cell wall hydrolase
I8N73_11930	COG2339	peptidase activity
I8N73_11935	COG0492	ferredoxin-NADP+ reductase activity
I8N73_11940	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N73_11945	COG4862	establishment of competence for transformation
I8N73_11950	COG1408	metallophosphoesterase
I8N73_11960	COG1388	LysM domain
I8N73_11965	COG1266	CAAX protease self-immunity
I8N73_11970	COG0514	ATP-dependent DNA helicase (RecQ)
I8N73_11975	COG4955	Helix-turn-helix domain
I8N73_11980	COG1141	Ferredoxin
I8N73_11985	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I8N73_11990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I8N73_12000	COG1595	DNA-templated transcription, initiation
I8N73_12005	COG5002	protein histidine kinase activity
I8N73_12010	COG0745	RESPONSE REGULATOR receiver
I8N73_12015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N73_12020	COG1333	cytochrome c biogenesis protein
I8N73_12025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_12030	COG1187	pseudouridine synthase activity
I8N73_12035	COG0700	Nucleoside recognition
I8N73_12040	COG2715	membrane protein required for spore maturation
I8N73_12045	COG1686	Belongs to the peptidase S11 family
I8N73_12070	COG1547	Domain of unknown function (DUF309)
I8N73_12075	COG0456	acetyltransferase
I8N73_12090	COG0307	riboflavin synthase, alpha
I8N73_12095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N73_12095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I8N73_12105	COG0681	Belongs to the peptidase S26 family
I8N73_12115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I8N73_12120	COG4086	secreted protein
I8N73_12125	COG0019	diaminopimelate decarboxylase activity
I8N73_12130	COG0697	spore germination
I8N73_12145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I8N73_12165	COG1191	sigma factor activity
I8N73_12175	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_12180	COG1686	Belongs to the peptidase S11 family
I8N73_12185	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I8N73_12190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I8N73_12195	COG4974	Belongs to the 'phage' integrase family
I8N73_12205	COG0735	belongs to the Fur family
I8N73_12210	COG1300	Membrane
I8N73_12225	COG0281	malic enzyme
I8N73_12230	COG1757	Na H antiporter
I8N73_12235	COG1027	Aspartate ammonia-lyase
I8N73_12240	COG0252	asparaginase activity
I8N73_12245	COG1396	sequence-specific DNA binding
I8N73_12250	COG1379	DNA repair
I8N73_12255	COG0494	nUDIX hydrolase
I8N73_12265	COG0667	Aldo Keto reductase
I8N73_12275	COG1073	alpha beta
I8N73_12285	COG4918	Iron-sulphur cluster biosynthesis
I8N73_12290	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I8N73_12290	COG0456	acetyltransferase
I8N73_12295	COG2329	Antibiotic biosynthesis monooxygenase
I8N73_12300	COG0456	acetyltransferase
I8N73_12305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I8N73_12330	COG0346	lactoylglutathione lyase activity
I8N73_12340	COG3048	D-serine ammonia-lyase activity
I8N73_12345	COG0300	oxidoreductase activity
I8N73_12350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_12355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N73_12360	COG1024	Enoyl-CoA hydratase
I8N73_12365	COG3425	synthase
I8N73_12370	COG2124	cytochrome p450
I8N73_12375	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_12375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_12375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_12375	COG3321	synthase
I8N73_12380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_12380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_12380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_12380	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12380	COG3321	synthase
I8N73_12385	COG3321	synthase
I8N73_12385	COG0300	oxidoreductase activity
I8N73_12385	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_12385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_12385	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12390	COG0300	oxidoreductase activity
I8N73_12390	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_12390	COG3321	synthase
I8N73_12390	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_12395	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_12395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_12395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_12395	COG3321	synthase
I8N73_12400	COG3321	synthase
I8N73_12400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_12400	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12400	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_12400	COG0300	oxidoreductase activity
I8N73_12405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I8N73_12405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_12405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_12405	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12405	COG3321	synthase
I8N73_12410	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_12415	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_12430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I8N73_12430	COG2070	2-Nitropropane dioxygenase
I8N73_12435	COG0250	Participates in transcription elongation, termination and antitermination
I8N73_12455	COG0596	Alpha beta hydrolase
I8N73_12470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I8N73_12475	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I8N73_12490	COG0706	membrane insertase activity
I8N73_12495	COG2195	Cleaves the N-terminal amino acid of tripeptides
I8N73_12500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I8N73_12505	COG0346	lactoylglutathione lyase activity
I8N73_12515	COG1376	ErfK ybiS ycfS ynhG family protein
I8N73_12520	COG4129	membrane
I8N73_12525	COG1126	abc transporter atp-binding protein
I8N73_12530	COG0765	amino acid transport
I8N73_12535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_12545	COG1597	lipid kinase activity
I8N73_12550	COG0508	dehydrogenase complex catalyzes the overall conversion of
I8N73_12555	COG0022	dehydrogenase e1 component
I8N73_12560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I8N73_12565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I8N73_12570	COG3426	butyrate kinase activity
I8N73_12575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N73_12580	COG0280	phosphate acetyltransferase
I8N73_12585	COG3829	transcription factor binding
I8N73_12585	COG3290	protein histidine kinase activity
I8N73_12595	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I8N73_12600	COG2079	MmgE PrpD family protein
I8N73_12605	COG0372	Belongs to the citrate synthase family
I8N73_12610	COG1960	acyl-CoA dehydrogenase activity
I8N73_12615	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N73_12620	COG0183	Belongs to the thiolase family
I8N73_12625	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_12630	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_12655	COG1902	pentaerythritol trinitrate reductase activity
I8N73_12670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I8N73_12675	COG0745	RESPONSE REGULATOR receiver
I8N73_12680	COG0750	zinc metalloprotease
I8N73_12685	COG0497	DNA recombination
I8N73_12695	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I8N73_12705	COG0142	geranyltranstransferase activity
I8N73_12715	COG1570	exodeoxyribonuclease VII activity
I8N73_12730	COG1302	Protein conserved in bacteria
I8N73_12735	COG0439	Biotin carboxylase
I8N73_12740	COG0511	ligase activity, forming carbon-carbon bonds
I8N73_12780	COG3854	ATPases associated with a variety of cellular activities
I8N73_12795	COG0006	proline dipeptidase activity
I8N73_12805	COG3872	metal-dependent enzyme
I8N73_12815	COG1752	Esterase of the alpha-beta hydrolase superfamily
I8N73_12830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N73_12850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N73_12865	COG1396	sequence-specific DNA binding
I8N73_12875	COG0681	Belongs to the peptidase S26 family
I8N73_12900	COG4940	Competence protein ComGF
I8N73_12910	COG4970	Tfp pilus assembly protein FimT
I8N73_12915	COG4537	Required for transformation and DNA binding
I8N73_12920	COG1459	type II secretion system
I8N73_12925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I8N73_12930	COG0598	Magnesium transport protein CorA
I8N73_12935	COG1253	flavin adenine dinucleotide binding
I8N73_12940	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_12950	COG1393	Belongs to the ArsC family
I8N73_12960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_12970	COG0011	TIGRFAM Protein of
I8N73_12980	COG2866	Carboxypeptidase
I8N73_12985	COG1940	carbohydrate kinase activity
I8N73_12990	COG4483	Protein conserved in bacteria
I8N73_12995	COG1757	Na H antiporter
I8N73_13005	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I8N73_13020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N73_13025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N73_13030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I8N73_13035	COG0581	inorganic phosphate transmembrane transporter activity
I8N73_13040	COG0573	inorganic phosphate transmembrane transporter activity
I8N73_13045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I8N73_13050	COG0768	penicillin binding
I8N73_13055	COG0477	Major facilitator Superfamily
I8N73_13060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I8N73_13065	COG2839	Protein conserved in bacteria
I8N73_13070	COG5521	maltodextrose utilization protein MalA
I8N73_13075	COG1388	LysM domain
I8N73_13085	COG4709	membrane
I8N73_13090	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I8N73_13095	COG0735	belongs to the Fur family
I8N73_13100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_13115	COG0513	Belongs to the DEAD box helicase family
I8N73_13130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I8N73_13135	COG2384	SAM-dependent methyltransferase
I8N73_13140	COG2010	Cytochrome c
I8N73_13145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I8N73_13150	COG0358	DNA primase activity
I8N73_13165	COG0517	IMP dehydrogenase activity
I8N73_13170	COG0751	glycine-tRNA ligase activity
I8N73_13190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I8N73_13195	COG0295	cytidine deaminase activity
I8N73_13200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I8N73_13210	COG1480	7TM receptor with intracellular HD hydrolase
I8N73_13215	COG1702	phosphate starvation-inducible protein PhoH
I8N73_13220	COG0561	phosphatase activity
I8N73_13235	COG4864	UPF0365 protein
I8N73_13240	COG1030	water channel activity
I8N73_13245	COG1610	YqeY-like protein
I8N73_13255	COG1283	sodium-dependent phosphate transmembrane transporter activity
I8N73_13260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I8N73_13265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I8N73_13295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I8N73_13310	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_13325	COG1466	dna polymerase III delta subunit
I8N73_13340	COG0658	competence protein
I8N73_13340	COG2333	competence protein COMEC
I8N73_13345	COG2131	deaminase
I8N73_13350	COG1555	photosystem II stabilization
I8N73_13350	COG1596	polysaccharide export
I8N73_13355	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I8N73_13360	COG2226	methyltransferase
I8N73_13365	COG0799	negative regulation of ribosome biogenesis
I8N73_13370	COG1713	HD superfamily hydrolase involved in NAD metabolism
I8N73_13380	COG1534	Rna-binding protein
I8N73_13385	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I8N73_13390	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I8N73_13395	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I8N73_13405	COG2755	lipolytic protein G-D-S-L family
I8N73_13415	COG0398	Pfam SNARE associated Golgi protein
I8N73_13450	COG5444	nuclease activity
I8N73_13455	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_13470	COG0583	DNA-binding transcription factor activity
I8N73_13485	COG5002	protein histidine kinase activity
I8N73_13485	COG0642	Histidine kinase
I8N73_13490	COG0745	RESPONSE REGULATOR receiver
I8N73_13495	COG2311	Membrane
I8N73_13505	COG0454	-acetyltransferase
I8N73_13510	COG0563	adenylate kinase activity
I8N73_13520	COG2814	Major facilitator Superfamily
I8N73_13530	COG0456	acetyltransferase
I8N73_13535	COG2318	DinB family
I8N73_13545	COG0561	phosphatase activity
I8N73_13550	COG0561	phosphatase activity
I8N73_13560	COG1482	cell wall glycoprotein biosynthetic process
I8N73_13565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_13565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_13565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I8N73_13570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_13570	COG3711	transcriptional antiterminator
I8N73_13580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I8N73_13585	COG0583	DNA-binding transcription factor activity
I8N73_13590	COG2814	Major facilitator Superfamily
I8N73_13595	COG2124	cytochrome p450
I8N73_13595	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N73_13600	COG1309	transcriptional regulator
I8N73_13605	COG2226	methyltransferase
I8N73_13620	COG2116	formate transmembrane transporter activity
I8N73_13625	COG5609	conserved protein (DUF2294)
I8N73_13630	COG3383	formate dehydrogenase (NAD+) activity
I8N73_13635	COG2427	Protein of unknown function (DUF1641)
I8N73_13645	COG0626	cystathionine gamma-synthase activity
I8N73_13650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N73_13675	COG0768	penicillin binding
I8N73_13690	COG0826	peptidase U32
I8N73_13695	COG0826	peptidase U32
I8N73_13700	COG4122	O-methyltransferase activity
I8N73_13705	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I8N73_13720	COG4472	Bacterial protein of unknown function (DUF965)
I8N73_13730	COG0628	permease
I8N73_13735	COG1126	abc transporter atp-binding protein
I8N73_13740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_13745	COG0765	amino acid transport
I8N73_13750	COG0765	amino acid transport
I8N73_13765	COG3881	PFAM PRC-barrel domain
I8N73_13770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I8N73_13775	COG0457	Tetratricopeptide repeat
I8N73_13785	COG1104	cysteine desulfurase activity
I8N73_13790	COG1959	2 iron, 2 sulfur cluster binding
I8N73_13795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I8N73_13800	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I8N73_13825	COG4991	sh3 domain protein
I8N73_13825	COG3103	Sh3 type 3 domain protein
I8N73_13825	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_13835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I8N73_13845	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I8N73_13845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I8N73_13850	COG5416	Lipopolysaccharide assembly protein A domain
I8N73_13855	COG0490	domain, Protein
I8N73_13860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N73_13860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I8N73_13870	COG2244	polysaccharide biosynthetic process
I8N73_13875	COG2323	membrane
I8N73_13885	COG1862	Preprotein translocase
I8N73_13930	COG1388	LysM domain
I8N73_13940	COG0157	Belongs to the NadC ModD family
I8N73_13945	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I8N73_13950	COG1104	cysteine desulfurase activity
I8N73_13955	COG1827	regulation of RNA biosynthetic process
I8N73_13960	COG0077	Prephenate dehydratase
I8N73_13975	COG3290	protein histidine kinase activity
I8N73_13980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I8N73_13985	COG2868	ribosomal protein
I8N73_13995	COG1994	Peptidase M50
I8N73_14000	COG0739	heme binding
I8N73_14005	COG2894	cell division
I8N73_14015	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I8N73_14025	COG1077	Cell shape determining protein MreB Mrl
I8N73_14045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I8N73_14050	COG0285	dihydrofolate synthase activity
I8N73_14055	COG0525	valine-tRNA ligase activity
I8N73_14065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N73_14070	COG1388	LysM domain
I8N73_14080	COG0113	porphobilinogen synthase activity
I8N73_14085	COG1587	Uroporphyrinogen-III synthase
I8N73_14095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I8N73_14115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I8N73_14120	COG1067	ATP-dependent peptidase activity
I8N73_14120	COG0470	DNA polymerase III
I8N73_14135	COG0457	Tetratricopeptide repeat
I8N73_14135	COG1477	protein flavinylation
I8N73_14150	COG0473	3-isopropylmalate dehydrogenase activity
I8N73_14165	COG0440	acetolactate synthase activity
I8N73_14170	COG0028	Belongs to the TPP enzyme family
I8N73_14200	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I8N73_14220	COG0622	Phosphoesterase
I8N73_14225	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I8N73_14235	COG5401	PFAM Sporulation and spore germination
I8N73_14245	COG1846	Transcriptional regulator
I8N73_14250	COG2197	response regulator
I8N73_14255	COG0824	Thioesterase
I8N73_14260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I8N73_14265	COG1053	succinate dehydrogenase
I8N73_14270	COG2009	succinate dehydrogenase
I8N73_14275	COG1719	4-vinyl reductase, 4VR
I8N73_14280	COG0527	aspartate kinase activity
I8N73_14290	COG3118	belongs to the thioredoxin family
I8N73_14295	COG3534	alpha-L-arabinofuranosidase
I8N73_14300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I8N73_14305	COG2086	electron transfer activity
I8N73_14310	COG1024	Enoyl-CoA hydratase
I8N73_14315	COG1309	transcriptional regulator
I8N73_14320	COG0318	PFAM AMP-dependent synthetase and ligase
I8N73_14330	COG3766	membrane
I8N73_14340	COG1796	DNA polymerase
I8N73_14340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N73_14345	COG1286	toxin biosynthetic process
I8N73_14365	COG0072	phenylalanine-tRNA ligase activity
I8N73_14365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_14370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I8N73_14375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I8N73_14385	COG3835	regulator
I8N73_14390	COG0277	FAD linked oxidase domain protein
I8N73_14395	COG0247	lactate metabolic process
I8N73_14400	COG1966	Carbon starvation protein
I8N73_14405	COG3534	alpha-L-arabinofuranosidase
I8N73_14410	COG0395	ABC-type sugar transport system, permease component
I8N73_14415	COG1175	transmembrane transport
I8N73_14420	COG1653	transport
I8N73_14430	COG0647	UMP catabolic process
I8N73_14435	COG0235	Class ii aldolase
I8N73_14440	COG1069	ribulokinase activity
I8N73_14445	COG2160	L-arabinose isomerase activity
I8N73_14450	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_14455	COG1363	Peptidase, m42
I8N73_14465	COG3326	Membrane
I8N73_14470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I8N73_14480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I8N73_14485	COG1346	cytolysis
I8N73_14490	COG1380	Effector of murein hydrolase LrgA
I8N73_14495	COG3279	Response regulator of the LytR AlgR family
I8N73_14500	COG3275	phosphorelay sensor kinase activity
I8N73_14505	COG1011	Hydrolase
I8N73_14520	COG0398	Pfam SNARE associated Golgi protein
I8N73_14525	COG1484	DNA-dependent DNA replication
I8N73_14530	COG3611	Membrane attachment protein
I8N73_14545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N73_14550	COG1733	regulation of RNA biosynthetic process
I8N73_14555	COG2814	Major facilitator Superfamily
I8N73_14560	COG0656	L-ascorbic acid biosynthetic process
I8N73_14565	COG0237	dephospho-CoA kinase activity
I8N73_14570	COG1971	Probably functions as a manganese efflux pump
I8N73_14575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I8N73_14580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N73_14580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I8N73_14585	COG5002	protein histidine kinase activity
I8N73_14590	COG0745	RESPONSE REGULATOR receiver
I8N73_14600	COG0538	isocitrate dehydrogenase activity
I8N73_14605	COG0372	Belongs to the citrate synthase family
I8N73_14625	COG0628	permease
I8N73_14630	COG3030	protein affecting phage T7 exclusion by the F plasmid
I8N73_14635	COG0469	pyruvate kinase activity
I8N73_14655	COG0281	malic enzyme
I8N73_14660	COG0587	DNA-directed DNA polymerase activity
I8N73_14680	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I8N73_14690	COG4109	DRTGG domain
I8N73_14700	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_14715	COG0521	Mo-molybdopterin cofactor biosynthetic process
I8N73_14725	COG0827	DNA restriction-modification system
I8N73_14730	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I8N73_14735	COG3874	Sporulation protein YtfJ
I8N73_14745	COG1714	RDD family
I8N73_14750	COG0616	signal peptide processing
I8N73_14755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I8N73_14760	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I8N73_14765	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N73_14780	COG1104	cysteine desulfurase activity
I8N73_14785	COG1114	Component of the transport system for branched-chain amino acids
I8N73_14795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I8N73_14800	COG1309	transcriptional regulator
I8N73_14805	COG1956	GAF domain-containing protein
I8N73_14810	COG2199	diguanylate cyclase activity
I8N73_14810	COG2203	Gaf domain
I8N73_14820	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_14825	COG4282	regulation of fungal-type cell wall biogenesis
I8N73_14840	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8N73_14840	COG1017	nitric oxide dioxygenase activity
I8N73_14865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I8N73_14870	COG1378	Sugar-specific transcriptional regulator TrmB
I8N73_14890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I8N73_14895	COG0454	-acetyltransferase
I8N73_14900	COG0517	IMP dehydrogenase activity
I8N73_14905	COG0123	including yeast histone deacetylase and acetoin utilization protein
I8N73_14910	COG1360	Flagellar Motor Protein
I8N73_14915	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I8N73_14920	COG1609	Transcriptional regulator
I8N73_14925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I8N73_14925	COG1605	Chorismate mutase
I8N73_14930	COG3118	belongs to the thioredoxin family
I8N73_14935	COG4980	gas vesicle protein
I8N73_14940	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I8N73_14950	COG1674	ftsk spoiiie
I8N73_14955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I8N73_14965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_14975	COG1363	Peptidase, m42
I8N73_14980	COG5584	Small secreted protein
I8N73_14985	COG0281	malic enzyme
I8N73_14990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I8N73_15005	COG0510	thiamine kinase activity
I8N73_15010	COG1597	lipid kinase activity
I8N73_15020	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I8N73_15025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I8N73_15030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_15035	COG2252	PERMEase
I8N73_15040	COG4473	ABC transporter
I8N73_15045	COG1131	(ABC) transporter
I8N73_15050	COG1349	DNA-binding transcription factor activity
I8N73_15055	COG1187	pseudouridine synthase activity
I8N73_15060	COG2244	polysaccharide biosynthetic process
I8N73_15065	COG2081	HI0933 family
I8N73_15070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I8N73_15080	COG1609	Transcriptional regulator
I8N73_15085	COG1653	transport
I8N73_15090	COG1175	transmembrane transport
I8N73_15095	COG0395	ABC-type sugar transport system, permease component
I8N73_15100	COG1486	melibiose metabolic process
I8N73_15110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I8N73_15125	COG2202	Pas domain
I8N73_15125	COG1366	Belongs to the anti-sigma-factor antagonist family
I8N73_15130	COG2814	Major facilitator Superfamily
I8N73_15135	COG5522	Integral membrane protein (intg_mem_TP0381)
I8N73_15140	COG0577	efflux transmembrane transporter activity
I8N73_15145	COG1136	(ABC) transporter
I8N73_15150	COG2205	protein histidine kinase activity
I8N73_15155	COG0745	RESPONSE REGULATOR receiver
I8N73_15160	COG0577	efflux transmembrane transporter activity
I8N73_15165	COG1136	(ABC) transporter
I8N73_15185	COG1131	(ABC) transporter
I8N73_15190	COG1725	Transcriptional regulator
I8N73_15200	COG0640	Transcriptional regulator
I8N73_15205	COG0477	Major facilitator Superfamily
I8N73_15210	COG1242	4 iron, 4 sulfur cluster binding
I8N73_15215	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I8N73_15225	COG0584	glycerophosphoryl diester phosphodiesterase
I8N73_15235	COG2267	carboxylic ester hydrolase activity
I8N73_15240	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I8N73_15245	COG1113	amino acid transport
I8N73_15250	COG0367	asparagine synthase
I8N73_15270	COG1506	peptidase
I8N73_15275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I8N73_15280	COG1116	anion transmembrane transporter activity
I8N73_15285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I8N73_15290	COG0494	nUDIX hydrolase
I8N73_15295	COG4824	toxin secretion phage lysis holin
I8N73_15300	COG0783	Belongs to the Dps family
I8N73_15325	COG0288	reversible hydration of carbon dioxide
I8N73_15335	COG1271	oxidase subunit
I8N73_15340	COG1294	oxidase, subunit
I8N73_15350	COG4948	Mandelate Racemase Muconate Lactonizing
I8N73_15360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I8N73_15365	COG0596	Alpha beta hydrolase
I8N73_15375	COG1169	isochorismate synthase
I8N73_15380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I8N73_15385	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I8N73_15510	COG3859	Proton-coupled thiamine transporter YuaJ
I8N73_15515	COG2268	Band 7 protein
I8N73_15520	COG1585	Membrane protein implicated in regulation of membrane protease activity
I8N73_15525	COG2318	DinB family
I8N73_15535	COG1454	alcohol dehydrogenase
I8N73_15540	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_15545	COG1510	regulation of RNA biosynthetic process
I8N73_15555	COG0569	domain protein
I8N73_15560	COG1705	Flagellar rod assembly protein muramidase FlgJ
I8N73_15565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I8N73_15565	COG1017	nitric oxide dioxygenase activity
I8N73_15590	COG0628	permease
I8N73_15595	COG0673	inositol 2-dehydrogenase activity
I8N73_15600	COG0693	protein deglycase activity
I8N73_15605	COG0840	transmembrane signaling receptor activity
I8N73_15610	COG0840	transmembrane signaling receptor activity
I8N73_15615	COG0840	transmembrane signaling receptor activity
I8N73_15620	COG0840	transmembrane signaling receptor activity
I8N73_15635	COG2070	2-Nitropropane dioxygenase
I8N73_15640	COG0432	Pfam Uncharacterised protein family UPF0047
I8N73_15645	COG0366	Alpha amylase catalytic
I8N73_15650	COG1253	flavin adenine dinucleotide binding
I8N73_15655	COG2738	Putative neutral zinc metallopeptidase
I8N73_15670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I8N73_15695	COG1335	isochorismatase
I8N73_15700	COG1979	alcohol dehydrogenase
I8N73_15705	COG1979	alcohol dehydrogenase
I8N73_15710	COG2155	Conserved Protein
I8N73_15715	COG1098	S1 RNA binding domain
I8N73_15720	COG0436	Aminotransferase
I8N73_15725	COG1522	sequence-specific DNA binding
I8N73_15730	COG2267	carboxylic ester hydrolase activity
I8N73_15740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I8N73_15745	COG2205	protein histidine kinase activity
I8N73_15755	COG5018	Exonuclease
I8N73_15760	COG2814	Major facilitator Superfamily
I8N73_15765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_15770	COG3011	Protein conserved in bacteria
I8N73_15780	COG3290	protein histidine kinase activity
I8N73_15785	COG4565	transcriptional regulatory protein
I8N73_15790	COG1744	ABC transporter substrate-binding protein PnrA-like
I8N73_15795	COG3845	ABC transporter
I8N73_15800	COG4603	Belongs to the binding-protein-dependent transport system permease family
I8N73_15805	COG1079	Belongs to the binding-protein-dependent transport system permease family
I8N73_15815	COG2111	Na H antiporter
I8N73_15815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I8N73_15820	COG2111	Na H antiporter
I8N73_15825	COG1006	Multisubunit Na H antiporter MnhC subunit
I8N73_15830	COG0651	ATP synthesis coupled electron transport
I8N73_15835	COG1863	multisubunit Na H antiporter MnhE subunit
I8N73_15840	COG2212	antiporter activity
I8N73_15845	COG1320	monovalent cation:proton antiporter activity
I8N73_15850	COG2050	protein possibly involved in aromatic compounds catabolism
I8N73_15855	COG2197	response regulator
I8N73_15860	COG4585	Histidine kinase
I8N73_15870	COG0142	geranyltranstransferase activity
I8N73_15885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I8N73_15890	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I8N73_15895	COG1335	isochorismatase
I8N73_15900	COG5506	Protein of unknown function (DUF1694)
I8N73_15915	COG0628	permease
I8N73_15925	COG1418	mRNA catabolic process
I8N73_15930	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_15940	COG1511	domain protein
I8N73_15945	COG0433	COG0433 Predicted ATPase
I8N73_15945	COG1674	ftsk spoiiie
I8N73_15950	COG4499	WXG100 protein secretion system (Wss), protein YukC
I8N73_15955	COG5417	Belongs to the EsaB family
I8N73_15960	COG4842	Belongs to the WXG100 family
I8N73_15965	COG2508	Transcriptional regulator
I8N73_15965	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I8N73_15970	COG0686	Belongs to the AlaDH PNT family
I8N73_15975	COG5634	Uncharacterized conserved protein (DUF2278)
I8N73_15980	COG3251	PFAM MbtH domain protein
I8N73_15985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I8N73_15990	COG1535	isochorismatase
I8N73_15990	COG3433	isochorismatase activity
I8N73_15995	COG1021	2,3-dihydroxybenzoate-AMP ligase
I8N73_16000	COG1169	isochorismate synthase
I8N73_16005	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_16010	COG2819	hydrolase of the alpha beta superfamily
I8N73_16015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I8N73_16020	COG1268	BioY protein
I8N73_16025	COG2056	Na+-H+ antiporter family
I8N73_16035	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I8N73_16040	COG3584	3D domain protein
I8N73_16055	COG1252	NADH dehydrogenase
I8N73_16085	COG1131	(ABC) transporter
I8N73_16105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I8N73_16110	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
I8N73_16115	COG0316	Belongs to the HesB IscA family
I8N73_16125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N73_16135	COG1252	NADH dehydrogenase
I8N73_16140	COG4837	Protein of unknown function (DUF1462)
I8N73_16145	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I8N73_16150	COG0823	Involved in the tonB-independent uptake of proteins
I8N73_16150	COG4946	Tricorn protease homolog
I8N73_16150	COG1506	peptidase
I8N73_16160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I8N73_16165	COG0460	homoserine dehydrogenase
I8N73_16170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I8N73_16175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I8N73_16180	COG0647	UMP catabolic process
I8N73_16185	COG2445	Protein of unknown function DUF86
I8N73_16190	COG4470	Protein conserved in bacteria
I8N73_16200	COG0739	heme binding
I8N73_16210	COG0737	Belongs to the 5'-nucleotidase family
I8N73_16215	COG0730	response to heat
I8N73_16220	COG1801	Protein of unknown function DUF72
I8N73_16235	COG2508	Transcriptional regulator
I8N73_16250	COG2814	Major facilitator Superfamily
I8N73_16255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I8N73_16260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I8N73_16265	COG2356	endonuclease I
I8N73_16270	COG3842	ATPase activity
I8N73_16275	COG2188	Transcriptional regulator
I8N73_16280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N73_16285	COG0395	ABC-type sugar transport system, permease component
I8N73_16290	COG1175	transmembrane transport
I8N73_16295	COG1653	transport
I8N73_16300	COG2222	sugar isomerase
I8N73_16305	COG0789	Transcriptional regulator
I8N73_16330	COG0322	excinuclease ABC activity
I8N73_16335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I8N73_16340	COG2226	methyltransferase
I8N73_16350	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_16355	COG0719	Fe-S assembly protein
I8N73_16360	COG0822	iron-sulfur transferase activity
I8N73_16365	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I8N73_16370	COG0719	Fe-S assembly protein
I8N73_16375	COG0396	ATPase activity
I8N73_16385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8N73_16390	COG1464	Belongs to the NlpA lipoprotein family
I8N73_16395	COG2011	ABC-type metal ion transport system permease component
I8N73_16400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I8N73_16410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I8N73_16415	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I8N73_16430	COG1393	Belongs to the ArsC family
I8N73_16435	COG1960	acyl-CoA dehydrogenase activity
I8N73_16440	COG0183	Belongs to the thiolase family
I8N73_16445	COG1024	Enoyl-CoA hydratase
I8N73_16445	COG1250	3-hydroxyacyl-CoA dehydrogenase
I8N73_16460	COG0477	Major facilitator Superfamily
I8N73_16470	COG5577	PFAM Coat F domain
I8N73_16475	COG1846	Transcriptional regulator
I8N73_16480	COG0477	Major facilitator Superfamily
I8N73_16485	COG0583	DNA-binding transcription factor activity
I8N73_16510	COG1120	ATPase activity
I8N73_16525	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_16530	COG0783	Belongs to the Dps family
I8N73_16535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_16540	COG0745	RESPONSE REGULATOR receiver
I8N73_16545	COG2770	Histidine kinase
I8N73_16545	COG2205	protein histidine kinase activity
I8N73_16555	COG1309	transcriptional regulator
I8N73_16560	COG0114	fumarate hydratase activity
I8N73_16570	COG0697	spore germination
I8N73_16575	COG0814	amino acid
I8N73_16585	COG2197	response regulator
I8N73_16590	COG4585	Histidine kinase
I8N73_16595	COG4758	membrane
I8N73_16600	COG3595	metallopeptidase activity
I8N73_16605	COG1842	Phage shock protein A
I8N73_16610	COG4758	membrane
I8N73_16615	COG2814	Major facilitator Superfamily
I8N73_16620	COG2096	Adenosyltransferase
I8N73_16625	COG1120	ATPase activity
I8N73_16630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_16635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_16640	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_16645	COG3386	PFAM SMP-30 Gluconolaconase
I8N73_16650	COG2205	protein histidine kinase activity
I8N73_16655	COG0745	RESPONSE REGULATOR receiver
I8N73_16665	COG1191	sigma factor activity
I8N73_16675	COG2140	Oxalate decarboxylase
I8N73_16685	COG1120	ATPase activity
I8N73_16690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_16695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_16700	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_16705	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I8N73_16710	COG0531	amino acid
I8N73_16720	COG1988	membrane-bound metal-dependent
I8N73_16725	COG1368	sulfuric ester hydrolase activity
I8N73_16730	COG1910	domain protein
I8N73_16735	COG0725	ABC transporter, periplasmic molybdate-binding protein
I8N73_16740	COG4149	molybdate abc transporter
I8N73_16745	COG2197	response regulator
I8N73_16750	COG3850	Histidine kinase
I8N73_16755	COG1131	(ABC) transporter
I8N73_16765	COG0842	Transport permease protein
I8N73_16770	COG0656	L-ascorbic acid biosynthetic process
I8N73_16790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I8N73_16795	COG3973	AAA domain
I8N73_16800	COG2860	membrane
I8N73_16810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I8N73_16815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I8N73_16820	COG2217	Heavy metal translocating P-type atpase
I8N73_16825	COG2217	Heavy metal translocating P-type atpase
I8N73_16830	COG2608	mercury ion transmembrane transporter activity
I8N73_16835	COG1937	Protein conserved in bacteria
I8N73_16840	COG0673	inositol 2-dehydrogenase activity
I8N73_16850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_16855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I8N73_16860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_16865	COG1126	abc transporter atp-binding protein
I8N73_16870	COG0765	amino acid transport
I8N73_16875	COG0765	amino acid transport
I8N73_16880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_16885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I8N73_16890	COG0454	-acetyltransferase
I8N73_16895	COG0583	DNA-binding transcription factor activity
I8N73_16900	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_16905	COG2732	(Barnase) inhibitor
I8N73_16910	COG2732	(Barnase) inhibitor
I8N73_16925	COG0557	exoribonuclease II activity
I8N73_16930	COG1647	Serine aminopeptidase, S33
I8N73_16935	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I8N73_16940	COG1476	TRANSCRIPTIONal
I8N73_16945	COG1396	sequence-specific DNA binding
I8N73_16950	COG1396	sequence-specific DNA binding
I8N73_16955	COG1733	regulation of RNA biosynthetic process
I8N73_16980	COG1131	(ABC) transporter
I8N73_16985	COG1174	glycine betaine transport
I8N73_16990	COG1732	Glycine betaine
I8N73_16995	COG1174	glycine betaine transport
I8N73_17000	COG0517	IMP dehydrogenase activity
I8N73_17000	COG1125	glycine betaine transport
I8N73_17005	COG1510	regulation of RNA biosynthetic process
I8N73_17010	COG1174	glycine betaine transport
I8N73_17015	COG1732	Glycine betaine
I8N73_17020	COG1174	glycine betaine transport
I8N73_17025	COG1125	glycine betaine transport
I8N73_17025	COG0517	IMP dehydrogenase activity
I8N73_17030	COG1510	regulation of RNA biosynthetic process
I8N73_17035	COG2095	MarC family integral membrane protein
I8N73_17040	COG3064	Membrane
I8N73_17045	COG4640	response to antibiotic
I8N73_17050	COG0456	acetyltransferase
I8N73_17065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I8N73_17080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_17085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I8N73_17090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_17100	COG2234	aminopeptidase activity
I8N73_17120	COG0126	phosphoglycerate kinase activity
I8N73_17125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I8N73_17130	COG2390	Transcriptional regulator
I8N73_17135	COG2814	Major facilitator Superfamily
I8N73_17140	COG1609	Transcriptional regulator
I8N73_17145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_17155	COG0583	DNA-binding transcription factor activity
I8N73_17160	COG0697	spore germination
I8N73_17175	COG1609	Transcriptional regulator
I8N73_17185	COG0561	phosphatase activity
I8N73_17190	COG1737	Transcriptional regulator
I8N73_17195	COG1070	Carbohydrate kinase
I8N73_17220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_17225	COG2186	Transcriptional regulator
I8N73_17230	COG1620	l-lactate permease
I8N73_17235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I8N73_17245	COG5039	Polysaccharide pyruvyl transferase
I8N73_17250	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_17255	COG0110	maltose O-acetyltransferase activity
I8N73_17260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I8N73_17265	COG2244	polysaccharide biosynthetic process
I8N73_17270	COG1216	Glycosyl transferase, family 2
I8N73_17275	COG5039	Polysaccharide pyruvyl transferase
I8N73_17280	COG1216	Glycosyl transferase, family 2
I8N73_17290	COG0438	transferase activity, transferring glycosyl groups
I8N73_17295	COG1215	transferase activity, transferring glycosyl groups
I8N73_17300	COG0438	transferase activity, transferring glycosyl groups
I8N73_17305	COG1086	Polysaccharide biosynthesis protein
I8N73_17310	COG0489	protein tyrosine kinase activity
I8N73_17315	COG3944	biosynthesis protein
I8N73_17320	COG1396	sequence-specific DNA binding
I8N73_17325	COG2272	Belongs to the type-B carboxylesterase lipase family
I8N73_17330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I8N73_17335	COG2364	Membrane
I8N73_17340	COG0456	acetyltransferase
I8N73_17345	COG3479	Phenolic acid decarboxylase
I8N73_17395	COG1357	PFAM Pentapeptide repeats (8 copies)
I8N73_17415	COG2223	nitrite transmembrane transporter activity
I8N73_17420	COG1609	Transcriptional regulator
I8N73_17430	COG0583	DNA-binding transcription factor activity
I8N73_17435	COG2828	Protein conserved in bacteria
I8N73_17440	COG0477	Major facilitator Superfamily
I8N73_17440	COG2814	Major facilitator Superfamily
I8N73_17445	COG1611	Belongs to the LOG family
I8N73_17450	COG1694	Mazg nucleotide pyrophosphohydrolase
I8N73_17455	COG0659	secondary active sulfate transmembrane transporter activity
I8N73_17460	COG0288	reversible hydration of carbon dioxide
I8N73_17465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I8N73_17470	COG4290	ribonuclease
I8N73_17475	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I8N73_17480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_17490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I8N73_17500	COG1051	belongs to the nudix hydrolase family
I8N73_17505	COG0492	ferredoxin-NADP+ reductase activity
I8N73_17510	COG3883	PFAM NLP P60 protein
I8N73_17510	COG0791	NLP P60 protein
I8N73_17515	COG0457	Tetratricopeptide repeat
I8N73_17520	COG5002	protein histidine kinase activity
I8N73_17525	COG0745	RESPONSE REGULATOR receiver
I8N73_17530	COG1132	(ABC) transporter
I8N73_17535	COG0140	phosphoribosyl-ATP diphosphatase activity
I8N73_17535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I8N73_17560	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I8N73_17575	COG4990	cell redox homeostasis
I8N73_17580	COG0110	maltose O-acetyltransferase activity
I8N73_17600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I8N73_17610	COG2188	Transcriptional regulator
I8N73_17615	COG1309	transcriptional regulator
I8N73_17620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I8N73_17625	COG1950	PFAM Membrane protein of
I8N73_17630	COG1983	PspC domain protein
I8N73_17635	COG3595	metallopeptidase activity
I8N73_17650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I8N73_17660	COG4897	Protein conserved in bacteria
I8N73_17665	COG3848	Pyruvate phosphate dikinase
I8N73_17665	COG0574	Belongs to the PEP-utilizing enzyme family
I8N73_17670	COG1309	transcriptional regulator
I8N73_17675	COG2814	Major facilitator Superfamily
I8N73_17685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_17695	COG0793	Belongs to the peptidase S41A family
I8N73_17695	COG3409	Peptidoglycan-binding domain 1 protein
I8N73_17700	COG3420	alginic acid biosynthetic process
I8N73_17705	COG2177	Part of the ABC transporter FtsEX involved in
I8N73_17710	COG2884	Cell division ATP-binding protein ftsE
I8N73_17715	COG2010	Cytochrome c
I8N73_17720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_17735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I8N73_17750	COG1516	flagellar protein fliS
I8N73_17755	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I8N73_17760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N73_17780	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I8N73_17785	COG1256	bacterial-type flagellum assembly
I8N73_17785	COG4786	Flagellar basal body rod
I8N73_17790	COG3418	PFAM FlgN family protein
I8N73_17795	COG2747	anti-sigma28 factor FlgM
I8N73_17805	COG1040	competence protein
I8N73_17815	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I8N73_17820	COG1307	EDD domain protein, DegV family
I8N73_17825	COG2197	response regulator
I8N73_17830	COG4585	Histidine kinase
I8N73_17835	COG1739	Uncharacterized protein family UPF0029
I8N73_17840	COG1316	TRANSCRIPTIONal
I8N73_17845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I8N73_17850	COG0438	transferase activity, transferring glycosyl groups
I8N73_17855	COG1215	transferase activity, transferring glycosyl groups
I8N73_17860	COG3206	protein involved in exopolysaccharide biosynthesis
I8N73_17865	COG3307	-O-antigen
I8N73_17870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N73_17875	COG0297	glycogen (starch) synthase activity
I8N73_17875	COG0438	transferase activity, transferring glycosyl groups
I8N73_17880	COG2244	polysaccharide biosynthetic process
I8N73_17890	COG0860	N-Acetylmuramoyl-L-alanine amidase
I8N73_17890	COG2247	cell wall binding repeat
I8N73_17895	COG2247	cell wall binding repeat
I8N73_17895	COG2385	sporulation resulting in formation of a cellular spore
I8N73_17905	COG1316	TRANSCRIPTIONal
I8N73_17910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I8N73_17915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I8N73_17920	COG1134	teichoic acid transport
I8N73_17925	COG1682	transport, permease protein
I8N73_17930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N73_17935	COG0438	transferase activity, transferring glycosyl groups
I8N73_17940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I8N73_17945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I8N73_17950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N73_17955	COG4193	domain, Protein
I8N73_17960	COG1482	cell wall glycoprotein biosynthetic process
I8N73_17965	COG0697	spore germination
I8N73_17970	COG0814	amino acid
I8N73_17980	COG1215	transferase activity, transferring glycosyl groups
I8N73_17985	COG2814	Major facilitator Superfamily
I8N73_17990	COG1316	TRANSCRIPTIONal
I8N73_17995	COG0561	phosphatase activity
I8N73_18000	COG2433	Pfam Transposase IS66
I8N73_18005	COG0791	NLP P60 protein
I8N73_18015	COG2843	Capsule synthesis protein
I8N73_18025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I8N73_18030	COG0697	spore germination
I8N73_18035	COG0814	amino acid
I8N73_18045	COG1609	Transcriptional regulator
I8N73_18050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I8N73_18060	COG1129	ABC transporter
I8N73_18065	COG1172	Belongs to the binding-protein-dependent transport system permease family
I8N73_18070	COG1879	ABC-type sugar transport system periplasmic component
I8N73_18075	COG3103	Sh3 type 3 domain protein
I8N73_18080	COG2249	NAD(P)H dehydrogenase (quinone) activity
I8N73_18085	COG3527	Alpha-acetolactate decarboxylase
I8N73_18090	COG0028	Belongs to the TPP enzyme family
I8N73_18095	COG0583	DNA-binding transcription factor activity
I8N73_18100	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N73_18115	COG5337	Spore coat protein CotH
I8N73_18125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I8N73_18135	COG0405	Gamma-glutamyltransferase
I8N73_18140	COG1522	sequence-specific DNA binding
I8N73_18145	COG2059	Chromate
I8N73_18150	COG2059	Chromate
I8N73_18175	COG5444	nuclease activity
I8N73_18190	COG3878	Protein conserved in bacteria
I8N73_18195	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I8N73_18200	COG4464	protein tyrosine phosphatase activity
I8N73_18205	COG0489	protein tyrosine kinase activity
I8N73_18210	COG3944	biosynthesis protein
I8N73_18220	COG4715	Zinc finger, swim domain protein
I8N73_18225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I8N73_18230	COG0561	phosphatase activity
I8N73_18235	COG1349	DNA-binding transcription factor activity
I8N73_18240	COG0629	single-stranded DNA binding
I8N73_18265	COG0457	Tetratricopeptide repeat
I8N73_18270	COG4786	Flagellar basal body rod
I8N73_18275	COG4786	Flagellar basal body rod
I8N73_18280	COG1077	Cell shape determining protein MreB Mrl
I8N73_18285	COG1609	Transcriptional regulator
I8N73_18290	COG1846	Transcriptional regulator
I8N73_18295	COG2814	Major facilitator Superfamily
I8N73_18300	COG1953	Uracil, thiamine, allantoin
I8N73_18305	COG0477	Major facilitator Superfamily
I8N73_18310	COG1335	isochorismatase
I8N73_18315	COG0004	ammonium transporteR
I8N73_18320	COG0347	Belongs to the P(II) protein family
I8N73_18325	COG0772	Belongs to the SEDS family
I8N73_18330	COG0671	phosphoesterase, PA-phosphatase related
I8N73_18340	COG0739	heme binding
I8N73_18345	COG1247	-acetyltransferase
I8N73_18360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N73_18370	COG0726	polysaccharide deacetylase
I8N73_18375	COG1959	2 iron, 2 sulfur cluster binding
I8N73_18390	COG0831	urea catabolic process
I8N73_18400	COG1994	Peptidase M50
I8N73_18405	COG0457	Tetratricopeptide repeat
I8N73_18415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I8N73_18425	COG2304	oxidoreductase activity
I8N73_18430	COG2304	oxidoreductase activity
I8N73_18435	COG2385	sporulation resulting in formation of a cellular spore
I8N73_18440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N73_18450	COG4836	Membrane
I8N73_18520	COG0698	ribose 5-phosphate isomerase
I8N73_18525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I8N73_18535	COG0009	L-threonylcarbamoyladenylate synthase
I8N73_18540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I8N73_18560	COG2890	protein-(glutamine-N5) methyltransferase activity
I8N73_18565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I8N73_18570	COG0346	lactoylglutathione lyase activity
I8N73_18575	COG0789	Transcriptional regulator
I8N73_18580	COG0679	Auxin Efflux Carrier
I8N73_18585	COG0281	malic enzyme
I8N73_18600	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I8N73_18605	COG1494	fructose-1,6-bisphosphatase
I8N73_18610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I8N73_18620	COG0191	fructose-bisphosphate aldolase activity
I8N73_18625	COG2204	response regulator
I8N73_18630	COG4821	SIS domain
I8N73_18645	COG0247	lactate metabolic process
I8N73_18645	COG2181	nitrate reductase activity
I8N73_18650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N73_18665	COG1132	(ABC) transporter
I8N73_18670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I8N73_18680	COG2181	nitrate reductase activity
I8N73_18685	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I8N73_18690	COG1140	nitrate reductase beta subunit
I8N73_18695	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I8N73_18700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N73_18710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I8N73_18715	COG2223	nitrite transmembrane transporter activity
I8N73_18725	COG4506	Protein conserved in bacteria
I8N73_18735	COG3391	amine dehydrogenase activity
I8N73_18740	COG3391	amine dehydrogenase activity
I8N73_18745	COG0457	Tetratricopeptide repeat
I8N73_18785	COG0010	Belongs to the arginase family
I8N73_18790	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I8N73_18795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I8N73_18810	COG1994	Peptidase M50
I8N73_18815	COG1942	4-Oxalocrotonate Tautomerase
I8N73_18820	COG1846	Transcriptional regulator
I8N73_18825	COG0531	amino acid
I8N73_18830	COG3465	dGTPase activity
I8N73_18835	COG1078	dGTPase activity
I8N73_18850	COG1695	Transcriptional regulator
I8N73_18860	COG1131	(ABC) transporter
I8N73_18865	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I8N73_18895	COG0583	DNA-binding transcription factor activity
I8N73_18900	COG2855	membrane
I8N73_18905	COG0280	phosphate acetyltransferase
I8N73_18915	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_18920	COG0436	Aminotransferase
I8N73_18950	COG2814	Major facilitator Superfamily
I8N73_18955	COG2814	Major facilitator Superfamily
I8N73_18960	COG0833	amino acid
I8N73_18965	COG4187	Peptidase family M20/M25/M40
I8N73_18970	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_18975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I8N73_18985	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I8N73_18990	COG1091	dTDP-4-dehydrorhamnose reductase activity
I8N73_18995	COG1088	dTDP-glucose 4,6-dehydratase activity
I8N73_19000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I8N73_19005	COG3980	spore coat polysaccharide biosynthesis protein
I8N73_19010	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I8N73_19015	COG2089	acid synthase
I8N73_19020	COG0456	acetyltransferase
I8N73_19025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I8N73_19030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I8N73_19035	COG0463	Glycosyl transferase, family 2
I8N73_19045	COG2363	Small membrane protein
I8N73_19050	COG2233	PERMEase
I8N73_19065	COG1216	Glycosyl transferase, family 2
I8N73_19080	COG1695	Transcriptional regulator
I8N73_19085	COG0351	phosphomethylpyrimidine kinase
I8N73_19095	COG1621	beta-fructofuranosidase activity
I8N73_19100	COG1263	PTS System
I8N73_19100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_19105	COG3711	transcriptional antiterminator
I8N73_19115	COG1404	Belongs to the peptidase S8 family
I8N73_19120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I8N73_19125	COG0778	Nitroreductase
I8N73_19130	COG0772	Belongs to the SEDS family
I8N73_19135	COG0454	-acetyltransferase
I8N73_19155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I8N73_19160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I8N73_19165	COG2261	transglycosylase associated protein
I8N73_19170	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I8N73_19175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I8N73_19180	COG2246	polysaccharide biosynthetic process
I8N73_19185	COG1309	transcriptional regulator
I8N73_19205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I8N73_19210	COG2837	iron assimilation
I8N73_19215	COG2822	iron ion transport
I8N73_19230	COG0583	DNA-binding transcription factor activity
I8N73_19240	COG1346	cytolysis
I8N73_19245	COG1131	(ABC) transporter
I8N73_19270	COG4895	conserved protein (DUF2196)
I8N73_19280	COG0789	Transcriptional regulator
I8N73_19285	COG5504	Zn-dependent protease
I8N73_19290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I8N73_19295	COG0346	lactoylglutathione lyase activity
I8N73_19300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_19305	COG1404	Belongs to the peptidase S8 family
I8N73_19310	COG1442	glycosyl transferase family 8
I8N73_19315	COG1846	Transcriptional regulator
I8N73_19320	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I8N73_19325	COG2357	RelA SpoT domain protein
I8N73_19330	COG1575	Belongs to the MenA family. Type 1 subfamily
I8N73_19345	COG1696	Membrane protein involved in D-alanine export
I8N73_19355	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I8N73_19360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I8N73_19365	COG1486	melibiose metabolic process
I8N73_19370	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N73_19375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_19380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_19385	COG3711	transcriptional antiterminator
I8N73_19385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I8N73_19395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_19400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I8N73_19410	COG0640	Transcriptional regulator
I8N73_19415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I8N73_19420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_19425	COG1447	Phosphotransferase system cellobiose-specific component IIA
I8N73_19430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I8N73_19435	COG2723	6-phospho-beta-galactosidase activity
I8N73_19440	COG1940	carbohydrate kinase activity
I8N73_19445	COG1482	cell wall glycoprotein biosynthetic process
I8N73_19455	COG0753	catalase activity
I8N73_19460	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I8N73_19465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I8N73_19470	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I8N73_19475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I8N73_19480	COG4988	ABC transporter
I8N73_19485	COG1294	oxidase, subunit
I8N73_19490	COG1271	oxidase subunit
I8N73_19495	COG3493	citrate carrier protein
I8N73_19500	COG0726	polysaccharide deacetylase
I8N73_19505	COG3842	ATPase activity
I8N73_19510	COG2508	Transcriptional regulator
I8N73_19515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_19525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I8N73_19540	COG4894	glucomannan catabolic process
I8N73_19545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I8N73_19550	COG0500	methyltransferase
I8N73_19555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N73_19570	COG0693	protein deglycase activity
I8N73_19570	COG0753	catalase activity
I8N73_19575	COG2851	Citrate transporter
I8N73_19580	COG2273	Hydrolase Family 16
I8N73_19585	COG3711	transcriptional antiterminator
I8N73_19590	COG2270	Major facilitator Superfamily
I8N73_19595	COG0513	Belongs to the DEAD box helicase family
I8N73_19695	COG3209	COG3209 Rhs family protein
I8N73_19705	COG0697	spore germination
I8N73_19710	COG0589	response to stress
I8N73_19715	COG2723	6-phospho-beta-galactosidase activity
I8N73_19720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I8N73_19720	COG1263	PTS System
I8N73_19720	COG2190	(PTS) system
I8N73_19735	COG3507	Belongs to the glycosyl hydrolase 43 family
I8N73_19760	COG0010	Belongs to the arginase family
I8N73_19765	COG0833	amino acid
I8N73_19770	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I8N73_19775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I8N73_19785	COG2390	Transcriptional regulator
I8N73_19790	COG0561	phosphatase activity
I8N73_19820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I8N73_19825	COG5294	Protein conserved in bacteria
I8N73_19830	COG0577	efflux transmembrane transporter activity
I8N73_19835	COG1136	(ABC) transporter
I8N73_19840	COG2205	protein histidine kinase activity
I8N73_19845	COG0745	RESPONSE REGULATOR receiver
I8N73_19860	COG1082	Xylose isomerase domain protein TIM barrel
I8N73_19870	COG2814	Major facilitator Superfamily
I8N73_19900	COG1349	DNA-binding transcription factor activity
I8N73_19905	COG0667	Aldo Keto reductase
I8N73_19915	COG2814	Major facilitator Superfamily
I8N73_19925	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_19930	COG2197	response regulator
I8N73_19935	COG4585	Histidine kinase
I8N73_19940	COG3239	Fatty acid desaturase
I8N73_19945	COG1309	transcriptional regulator
I8N73_19950	COG1012	belongs to the aldehyde dehydrogenase family
I8N73_19955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I8N73_19965	COG0640	Transcriptional regulator
I8N73_19970	COG2814	Major facilitator Superfamily
I8N73_19975	COG1714	RDD family
I8N73_19985	COG0450	alkyl hydroperoxide reductase
I8N73_19990	COG3634	alkyl hydroperoxide reductase activity
I8N73_19995	COG3177	Filamentation induced by cAMP protein fic
I8N73_20000	COG1113	amino acid transport
I8N73_20010	COG2080	2 iron, 2 sulfur cluster binding
I8N73_20025	COG2068	MobA-Related Protein
I8N73_20030	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I8N73_20105	COG2003	Belongs to the UPF0758 family
I8N73_20145	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I8N73_20150	COG0667	Aldo Keto reductase
I8N73_20155	COG0456	acetyltransferase
I8N73_20160	COG0457	Tetratricopeptide repeat
I8N73_20165	COG0010	Belongs to the arginase family
I8N73_20170	COG0833	amino acid
I8N73_20175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I8N73_20180	COG5658	integral membrane protein
I8N73_20185	COG0640	Transcriptional regulator
I8N73_20190	COG3829	transcription factor binding
I8N73_20200	COG0488	(ABC) transporter
I8N73_20215	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I8N73_20220	COG5002	protein histidine kinase activity
I8N73_20220	COG3850	Histidine kinase
I8N73_20225	COG0745	RESPONSE REGULATOR receiver
I8N73_20230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I8N73_20235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I8N73_20240	COG4853	Protein conserved in bacteria
I8N73_20245	COG4863	YycH protein
I8N73_20250	COG5002	protein histidine kinase activity
I8N73_20255	COG0745	RESPONSE REGULATOR receiver
I8N73_20285	COG0346	lactoylglutathione lyase activity
I8N73_20290	COG0305	Participates in initiation and elongation during chromosome replication
I8N73_20305	COG3093	addiction module antidote protein HigA
I8N73_20310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I8N73_20325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I8N73_20330	COG0438	transferase activity, transferring glycosyl groups
I8N73_20350	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I8N73_20355	COG4241	membrane
I8N73_20365	COG5577	PFAM Coat F domain
I8N73_20370	COG1733	regulation of RNA biosynthetic process
I8N73_20380	COG0697	spore germination
I8N73_20385	COG1621	beta-fructofuranosidase activity
I8N73_20390	COG1621	beta-fructofuranosidase activity
I8N73_20395	COG1802	Transcriptional regulator
I8N73_20400	COG2318	DinB family
I8N73_20405	COG2211	Major facilitator Superfamily
I8N73_20410	COG0583	DNA-binding transcription factor activity
I8N73_20425	COG0778	Nitroreductase
I8N73_20430	COG1846	Transcriptional regulator
I8N73_20435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I8N73_20440	COG1846	Transcriptional regulator
I8N73_20445	COG2153	protein acetylation
I8N73_20455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I8N73_20460	COG0583	DNA-binding transcription factor activity
I8N73_20465	COG1028	Short-chain dehydrogenase reductase Sdr
I8N73_20475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I8N73_20480	COG0697	spore germination
I8N73_20485	COG1331	Highly conserved protein containing a thioredoxin domain
I8N73_20490	COG1266	CAAX protease self-immunity
I8N73_20495	COG2814	Major facilitator Superfamily
I8N73_20495	COG0477	Major facilitator Superfamily
I8N73_20500	COG0346	lactoylglutathione lyase activity
I8N73_20505	COG1609	Transcriptional regulator
I8N73_20510	COG0708	Exodeoxyribonuclease III
I8N73_20515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I8N73_20520	COG2169	Transcriptional regulator
I8N73_20530	COG0629	single-stranded DNA binding
I8N73_20540	COG0012	GTP binding
I8N73_20545	COG0243	molybdopterin cofactor binding
I8N73_20550	COG4481	Protein conserved in bacteria
I8N73_20555	COG3949	Membrane
I8N73_20570	COG1475	DNA binding
I8N73_20575	COG1192	Involved in chromosome partitioning
I8N73_20600	COG1847	R3H domain protein
I8N73_20605	COG0706	membrane insertase activity