locus-tag	class	description
ES966_00010	COG0592	DNA-directed DNA polymerase activity
ES966_00015	COG2501	S4 domain
ES966_00030	COG0187	DNA topoisomerase II activity
ES966_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES966_00070	COG0516	GMP reductase activity
ES966_00070	COG0517	IMP dehydrogenase activity
ES966_00075	COG1686	Belongs to the peptidase S11 family
ES966_00095	COG1929	Belongs to the glycerate kinase type-1 family
ES966_00105	COG1428	Deoxynucleoside kinase
ES966_00110	COG1428	Deoxynucleoside kinase
ES966_00115	COG3858	chitin binding
ES966_00115	COG1388	LysM domain
ES966_00120	COG1335	isochorismatase
ES966_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES966_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES966_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES966_00195	COG3853	Toxic anion resistance protein (TelA)
ES966_00200	COG1982	Orn Lys Arg decarboxylase major
ES966_00210	COG3870	Protein conserved in bacteria
ES966_00215	COG1728	Protein conserved in bacteria
ES966_00220	COG0470	DNA polymerase III
ES966_00225	COG1774	PSP1 C-terminal conserved region
ES966_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES966_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES966_00250	COG2002	toxin-antitoxin pair type II binding
ES966_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_00260	COG0084	hydrolase, TatD family'
ES966_00265	COG3583	domain protein
ES966_00265	COG3584	3D domain protein
ES966_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES966_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES966_00285	COG4466	Protein conserved in bacteria
ES966_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES966_00305	COG0251	oxidation-reduction process
ES966_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES966_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES966_00345	COG2002	toxin-antitoxin pair type II binding
ES966_00350	COG2244	polysaccharide biosynthetic process
ES966_00355	COG3956	TIGRFAM MazG family protein
ES966_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES966_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES966_00380	COG1098	S1 RNA binding domain
ES966_00395	COG2208	phosphoserine phosphatase activity
ES966_00400	COG2304	oxidoreductase activity
ES966_00405	COG0515	serine threonine protein kinase
ES966_00410	COG0037	tRNA processing
ES966_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES966_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES966_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES966_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES966_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
ES966_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES966_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES966_00475	COG1396	sequence-specific DNA binding
ES966_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES966_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES966_00565	COG4463	regulation of RNA biosynthetic process
ES966_00570	COG3880	PFAM UvrB UvrC protein
ES966_00580	COG0542	response to heat
ES966_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES966_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES966_00595	COG4956	integral membrane protein (PIN domain superfamily)
ES966_00615	COG1045	serine acetyltransferase
ES966_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES966_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES966_00635	COG3688	RNA-binding protein containing a PIN domain
ES966_00640	COG1595	DNA-templated transcription, initiation
ES966_00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES966_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES966_00655	COG0250	Participates in transcription elongation, termination and antitermination
ES966_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ES966_00675	COG0222	ribosome binding
ES966_00680	COG2813	Specifically methylates the guanine in position
ES966_00695	COG1358	cellular component organization or biogenesis
ES966_00720	COG0596	Alpha beta hydrolase
ES966_00725	COG0051	transcription antitermination factor activity, RNA binding
ES966_00740	COG0089	rRNA binding
ES966_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ES966_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ES966_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES966_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
ES966_00820	COG1841	ribosomal large subunit assembly
ES966_00830	COG0201	protein transport
ES966_00840	COG0024	Methionine aminopeptidase
ES966_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ES966_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES966_00880	COG1122	ATPase activity
ES966_00885	COG1122	ATPase activity
ES966_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES966_00910	COG2226	methyltransferase
ES966_00915	COG2318	DinB family
ES966_00925	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_00930	COG0489	protein tyrosine kinase activity
ES966_00940	COG2194	sulfuric ester hydrolase activity
ES966_00945	COG0726	polysaccharide deacetylase
ES966_01005	COG0738	Major facilitator superfamily
ES966_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES966_01020	COG1063	alcohol dehydrogenase
ES966_01025	COG0659	secondary active sulfate transmembrane transporter activity
ES966_01030	COG0385	Bile acid
ES966_01035	COG2819	hydrolase of the alpha beta superfamily
ES966_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_01055	COG2207	Transcriptional regulator
ES966_01060	COG3876	Protein conserved in bacteria
ES966_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
ES966_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES966_01075	COG1263	PTS System
ES966_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_01090	COG1683	Conserved Protein
ES966_01120	COG1595	DNA-templated transcription, initiation
ES966_01125	COG5662	AntiSigma factor
ES966_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES966_01135	COG4856	YbbR-like protein
ES966_01175	COG1063	alcohol dehydrogenase
ES966_01185	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_01225	COG1346	cytolysis
ES966_01230	COG1380	Effector of murein hydrolase LrgA
ES966_01235	COG1846	Transcriptional regulator
ES966_01240	COG1113	amino acid transport
ES966_01245	COG1011	Hydrolase
ES966_01250	COG4585	Histidine kinase
ES966_01255	COG2197	response regulator
ES966_01260	COG1131	(ABC) transporter
ES966_01300	COG0531	amino acid
ES966_01325	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_01330	COG2271	Major facilitator Superfamily
ES966_01345	COG2368	4-hydroxyphenylacetate
ES966_01355	COG3409	Peptidoglycan-binding domain 1 protein
ES966_01370	COG0371	Dehydrogenase
ES966_01380	COG1183	phosphatidylcholine synthase activity
ES966_01385	COG0586	Pfam SNARE associated Golgi protein
ES966_01390	COG0688	phosphatidylethanolamine metabolic process
ES966_01405	COG1301	dicarboxylic acid transport
ES966_01410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_01415	COG0833	amino acid
ES966_01420	COG2040	homocysteine
ES966_01425	COG1115	amino acid carrier protein
ES966_01430	COG2066	Belongs to the glutaminase family
ES966_01435	COG4191	Histidine kinase
ES966_01440	COG0784	Response regulator, receiver
ES966_01465	COG3773	Cell wall hydrolase
ES966_01475	COG3540	Alkaline phosphatase
ES966_01480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES966_01485	COG0805	protein transport
ES966_01495	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES966_01500	COG0477	Major facilitator Superfamily
ES966_01505	COG1309	transcriptional regulator
ES966_01510	COG0252	asparaginase activity
ES966_01515	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES966_01520	COG1405	negative regulation of cell septum assembly
ES966_01520	COG3012	SEC-C Motif Domain Protein
ES966_01525	COG0667	Aldo Keto reductase
ES966_01535	COG1595	DNA-templated transcription, initiation
ES966_01540	COG1595	DNA-templated transcription, initiation
ES966_01545	COG1876	peptidase activity
ES966_01550	COG0457	Tetratricopeptide repeat
ES966_01555	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_01575	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES966_01580	COG1121	(ABC) transporter
ES966_01585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES966_01590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_01595	COG2310	stress, protein
ES966_01600	COG2310	stress, protein
ES966_01605	COG2310	stress, protein
ES966_01610	COG0861	Integral membrane protein TerC family
ES966_01620	COG3853	Toxic anion resistance protein (TelA)
ES966_01625	COG0477	Major facilitator Superfamily
ES966_01630	COG4175	Glycine betaine
ES966_01630	COG0517	IMP dehydrogenase activity
ES966_01635	COG4176	ABC-type proline glycine betaine transport system permease component
ES966_01640	COG2113	Glycine betaine
ES966_01645	COG1473	amidohydrolase
ES966_01650	COG1288	antiporter activity
ES966_01660	COG0366	Alpha amylase catalytic
ES966_01670	COG2814	Major facilitator Superfamily
ES966_01675	COG1846	Transcriptional regulator
ES966_01680	COG1280	lysine exporter protein (LysE YggA)
ES966_01685	COG3403	YqcI/YcgG family
ES966_01690	COG1113	amino acid transport
ES966_01695	COG3665	Urea carboxylase-associated protein
ES966_01710	COG1660	Displays ATPase and GTPase activities
ES966_01720	COG2271	Major facilitator Superfamily
ES966_01725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES966_01730	COG3458	cephalosporin-C deacetylase activity
ES966_01735	COG3541	Predicted nucleotidyltransferase
ES966_01740	COG0506	proline dehydrogenase activity
ES966_01745	COG1012	belongs to the aldehyde dehydrogenase family
ES966_01755	COG2508	Transcriptional regulator
ES966_01765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES966_01765	COG1587	Uroporphyrinogen-III synthase
ES966_01770	COG2146	nitrite reductase [NAD(P)H] activity
ES966_01775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES966_01785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES966_01790	COG2223	nitrite transmembrane transporter activity
ES966_01795	COG0523	cobalamin synthesis protein
ES966_01800	COG1063	alcohol dehydrogenase
ES966_01805	COG1714	RDD family
ES966_01815	COG2723	6-phospho-beta-galactosidase activity
ES966_01825	COG3209	COG3209 Rhs family protein
ES966_01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES966_01835	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES966_01840	COG1733	regulation of RNA biosynthetic process
ES966_01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_01860	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES966_01875	COG2364	Membrane
ES966_01880	COG1126	abc transporter atp-binding protein
ES966_01885	COG0765	amino acid transport
ES966_01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_01895	COG0583	DNA-binding transcription factor activity
ES966_01900	COG0163	prenyltransferase activity
ES966_01905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ES966_01920	COG3104	oligopeptide transport
ES966_01925	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_01935	COG0697	spore germination
ES966_01945	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES966_01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_01965	COG0765	amino acid transport
ES966_01970	COG1126	abc transporter atp-binding protein
ES966_01980	COG2079	MmgE PrpD family protein
ES966_01985	COG1136	(ABC) transporter
ES966_01990	COG0577	efflux transmembrane transporter activity
ES966_01995	COG0745	RESPONSE REGULATOR receiver
ES966_02000	COG3850	Histidine kinase
ES966_02000	COG5002	protein histidine kinase activity
ES966_02005	COG0457	Tetratricopeptide repeat
ES966_02020	COG0527	aspartate kinase activity
ES966_02025	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_02030	COG4605	iron ion homeostasis
ES966_02035	COG4604	ABC transporter, ATP-binding protein
ES966_02040	COG4607	ABC-type enterochelin transport system periplasmic component
ES966_02045	COG2814	Major facilitator Superfamily
ES966_02050	COG1309	transcriptional regulator
ES966_02055	COG0778	Nitroreductase
ES966_02060	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES966_02065	COG0640	Transcriptional regulator
ES966_02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_02080	COG1012	belongs to the aldehyde dehydrogenase family
ES966_02085	COG4975	Glucose uptake
ES966_02090	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_02095	COG4549	nuclear export factor GLE1
ES966_02105	COG1349	DNA-binding transcription factor activity
ES966_02120	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_02130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES966_02140	COG0561	phosphatase activity
ES966_02150	COG1914	H( )-stimulated, divalent metal cation uptake system
ES966_02160	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES966_02165	COG1984	allophanate hydrolase subunit 2
ES966_02170	COG1414	Transcriptional regulator
ES966_02185	COG2329	Antibiotic biosynthesis monooxygenase
ES966_02195	COG4989	oxidoreductase activity
ES966_02200	COG3711	transcriptional antiterminator
ES966_02205	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_02210	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_02215	COG1917	Cupin 2, conserved barrel domain protein
ES966_02220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_02225	COG3871	stress protein (general stress protein 26)
ES966_02235	COG2814	Major facilitator Superfamily
ES966_02240	COG1522	sequence-specific DNA binding
ES966_02245	COG0551	DNA topoisomerase type I activity
ES966_02245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES966_02250	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ES966_02260	COG5298	Protein conserved in bacteria
ES966_02265	COG1215	transferase activity, transferring glycosyl groups
ES966_02275	COG0531	amino acid
ES966_02280	COG0494	nUDIX hydrolase
ES966_02285	COG0028	Belongs to the TPP enzyme family
ES966_02290	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_02290	COG3409	Peptidoglycan-binding domain 1 protein
ES966_02290	COG1388	LysM domain
ES966_02310	COG0457	Tetratricopeptide repeat
ES966_02340	COG1914	H( )-stimulated, divalent metal cation uptake system
ES966_02355	COG4876	unkown
ES966_02370	COG2217	Heavy metal translocating P-type atpase
ES966_02375	COG3729	General stress protein
ES966_02380	COG0662	Cupin 2, conserved barrel domain protein
ES966_02385	COG2329	Antibiotic biosynthesis monooxygenase
ES966_02390	COG3546	catalase activity
ES966_02395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES966_02405	COG4565	transcriptional regulatory protein
ES966_02410	COG1301	dicarboxylic acid transport
ES966_02415	COG0628	permease
ES966_02420	COG1131	(ABC) transporter
ES966_02425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES966_02435	COG1960	acyl-CoA dehydrogenase activity
ES966_02450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES966_02455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_02465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES966_02470	COG0513	Belongs to the DEAD box helicase family
ES966_02475	COG3402	PFAM membrane-flanked domain
ES966_02480	COG3428	Bacterial PH domain
ES966_02495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES966_02500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES966_02505	COG0864	Transcriptional regulator
ES966_02510	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES966_02515	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_02520	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_02525	COG2172	sigma factor antagonist activity
ES966_02545	COG1191	sigma factor activity
ES966_02550	COG2208	phosphoserine phosphatase activity
ES966_02555	COG2183	response to ionizing radiation
ES966_02605	COG0582	viral genome integration into host DNA
ES966_02610	COG2856	Zn peptidase
ES966_02615	COG1396	sequence-specific DNA binding
ES966_02700	COG0433	COG0433 Predicted ATPase
ES966_02735	COG0457	Tetratricopeptide repeat
ES966_02740	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES966_02750	COG0477	Major facilitator Superfamily
ES966_02770	COG2030	dehydratase
ES966_02785	COG1959	2 iron, 2 sulfur cluster binding
ES966_02790	COG2910	NAD(P)H-binding
ES966_02800	COG1309	transcriptional regulator
ES966_02805	COG3239	Fatty acid desaturase
ES966_02815	COG1278	Cold shock
ES966_02820	COG1329	Transcriptional regulator
ES966_02825	COG1794	racemase activity, acting on amino acids and derivatives
ES966_02840	COG3621	Patatin-like phospholipase
ES966_02850	COG0662	Cupin 2, conserved barrel domain protein
ES966_02865	COG0277	FAD linked oxidase domain protein
ES966_02890	COG0662	Cupin 2, conserved barrel domain protein
ES966_02895	COG2318	DinB family
ES966_02900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES966_02925	COG1064	alcohol dehydrogenase
ES966_02930	COG0789	Transcriptional regulator
ES966_02940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_02955	COG2814	Major facilitator Superfamily
ES966_02960	COG1309	transcriptional regulator
ES966_02965	COG5577	PFAM Coat F domain
ES966_02975	COG1063	alcohol dehydrogenase
ES966_02980	COG5577	PFAM Coat F domain
ES966_02995	COG4585	Histidine kinase
ES966_03000	COG2197	response regulator
ES966_03005	COG2409	Drug exporters of the RND superfamily
ES966_03010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
ES966_03020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_03025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_03035	COG2814	Major facilitator Superfamily
ES966_03040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_03050	COG0730	response to heat
ES966_03055	COG0456	acetyltransferase
ES966_03060	COG4978	Transcriptional regulator
ES966_03060	COG0789	Transcriptional regulator
ES966_03065	COG0697	spore germination
ES966_03070	COG1051	belongs to the nudix hydrolase family
ES966_03075	COG2226	methyltransferase
ES966_03080	COG0473	3-isopropylmalate dehydrogenase activity
ES966_03085	COG1802	Transcriptional regulator
ES966_03090	COG1819	glycosyl
ES966_03105	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES966_03110	COG1388	LysM domain
ES966_03115	COG2814	Major facilitator Superfamily
ES966_03120	COG2188	Transcriptional regulator
ES966_03125	COG2186	Transcriptional regulator
ES966_03135	COG2076	Multidrug Resistance protein
ES966_03140	COG2076	Multidrug Resistance protein
ES966_03145	COG1309	transcriptional regulator
ES966_03150	COG0531	amino acid
ES966_03160	COG3832	glyoxalase III activity
ES966_03165	COG0604	alcohol dehydrogenase
ES966_03175	COG2814	Major facilitator Superfamily
ES966_03215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES966_03220	COG0802	atpase or kinase
ES966_03225	COG1214	PFAM Peptidase M22, glycoprotease
ES966_03230	COG0456	acetyltransferase
ES966_03235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES966_03240	COG0488	(ABC) transporter
ES966_03255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES966_03260	COG0805	protein transport
ES966_03270	COG1266	CAAX protease self-immunity
ES966_03275	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ES966_03285	COG0156	8-amino-7-oxononanoate synthase activity
ES966_03305	COG3403	YqcI/YcgG family
ES966_03320	COG2814	Major facilitator Superfamily
ES966_03325	COG0457	Tetratricopeptide repeat
ES966_03330	COG1063	alcohol dehydrogenase
ES966_03335	COG2211	Major facilitator Superfamily
ES966_03340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES966_03350	COG1842	Phage shock protein A
ES966_03355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES966_03360	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES966_03365	COG4260	virion core protein, lumpy skin disease virus
ES966_03370	COG2755	lipolytic protein G-D-S-L family
ES966_03370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES966_03380	COG1595	DNA-templated transcription, initiation
ES966_03385	COG1063	alcohol dehydrogenase
ES966_03390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES966_03395	COG0823	Involved in the tonB-independent uptake of proteins
ES966_03410	COG2132	Multicopper oxidase
ES966_03415	COG1113	amino acid transport
ES966_03420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES966_03425	COG0714	Associated with various cellular activities
ES966_03430	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES966_03435	COG1305	Transglutaminase-like
ES966_03465	COG2211	Major facilitator Superfamily
ES966_03480	COG2252	PERMEase
ES966_03485	COG3064	Membrane
ES966_03505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES966_03510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES966_03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES966_03520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES966_03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES966_03540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES966_03550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES966_03555	COG0138	bifunctional purine biosynthesis protein purh
ES966_03560	COG0151	Belongs to the GarS family
ES966_03570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES966_03580	COG4496	protein, YerC YecD
ES966_03585	COG0069	glutamate synthase activity
ES966_03600	COG0210	DNA helicase
ES966_03610	COG4851	CamS sex pheromone cAM373 precursor
ES966_03615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES966_03620	COG1285	pathogenesis
ES966_03625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES966_03645	COG1309	transcriptional regulator
ES966_03655	COG1597	lipid kinase activity
ES966_03660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES966_03665	COG2197	response regulator
ES966_03675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_03685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_03695	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_03700	COG1131	(ABC) transporter
ES966_03740	COG5444	nuclease activity
ES966_03770	COG3546	catalase activity
ES966_03775	COG0454	-acetyltransferase
ES966_03785	COG2323	membrane
ES966_03790	COG2329	Antibiotic biosynthesis monooxygenase
ES966_03795	COG0346	lactoylglutathione lyase activity
ES966_03805	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_03810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ES966_03815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ES966_03830	COG5583	Uncharacterized small protein (DUF2292)
ES966_03835	COG0196	riboflavin kinase activity
ES966_03840	COG0670	Belongs to the BI1 family
ES966_03845	COG1846	Transcriptional regulator
ES966_03850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES966_03875	COG1131	(ABC) transporter
ES966_03890	COG1368	sulfuric ester hydrolase activity
ES966_03895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES966_03900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES966_03905	COG1442	glycosyl transferase family 8
ES966_03910	COG1216	Glycosyl transferase, family 2
ES966_03915	COG1442	glycosyl transferase family 8
ES966_03920	COG2223	nitrite transmembrane transporter activity
ES966_03925	COG0531	amino acid
ES966_03930	COG1012	belongs to the aldehyde dehydrogenase family
ES966_03935	COG0840	transmembrane signaling receptor activity
ES966_03940	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_03945	COG0463	Glycosyl transferase, family 2
ES966_03945	COG0457	Tetratricopeptide repeat
ES966_03950	COG0488	(ABC) transporter
ES966_03955	COG0789	Transcriptional regulator
ES966_03960	COG2814	Major facilitator Superfamily
ES966_03965	COG0488	(ABC) transporter
ES966_03970	COG0513	Belongs to the DEAD box helicase family
ES966_03980	COG2130	NADP-dependent
ES966_03995	COG3866	Pectate lyase
ES966_04000	COG0471	metal ion transport
ES966_04030	COG0745	RESPONSE REGULATOR receiver
ES966_04030	COG2972	Histidine kinase
ES966_04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_04055	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES966_04065	COG2258	MOSC domain
ES966_04085	COG0024	Methionine aminopeptidase
ES966_04090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_04090	COG1263	PTS System
ES966_04100	COG1368	sulfuric ester hydrolase activity
ES966_04110	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_04125	COG1263	PTS System
ES966_04125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_04130	COG0366	Alpha amylase catalytic
ES966_04135	COG2188	Transcriptional regulator
ES966_04140	COG0778	Nitroreductase
ES966_04155	COG0737	Belongs to the 5'-nucleotidase family
ES966_04160	COG0693	protein deglycase activity
ES966_04165	COG1609	Transcriptional regulator
ES966_04170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES966_04180	COG2814	Major facilitator Superfamily
ES966_04190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES966_04195	COG4980	gas vesicle protein
ES966_04200	COG1295	ribonuclease BN
ES966_04205	COG0477	Major facilitator Superfamily
ES966_04220	COG0668	transmembrane transport
ES966_04225	COG0535	radical SAM domain protein
ES966_04235	COG0726	polysaccharide deacetylase
ES966_04240	COG2084	Dehydrogenase
ES966_04250	COG0598	Magnesium transport protein CorA
ES966_04255	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES966_04260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES966_04270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES966_04275	COG4637	Psort location Cytoplasmic, score
ES966_04280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES966_04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_04295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES966_04300	COG3284	Transcriptional regulator
ES966_04310	COG1486	melibiose metabolic process
ES966_04315	COG1737	Transcriptional regulator
ES966_04325	COG1132	(ABC) transporter
ES966_04330	COG1132	(ABC) transporter
ES966_04335	COG2259	Doxx family
ES966_04340	COG2514	catechol 2,3-dioxygenase activity
ES966_04355	COG1695	Transcriptional regulator
ES966_04360	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES966_04365	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES966_04370	COG0574	Belongs to the PEP-utilizing enzyme family
ES966_04370	COG3848	Pyruvate phosphate dikinase
ES966_04375	COG2732	(Barnase) inhibitor
ES966_04380	COG2318	DinB family
ES966_04385	COG2814	Major facilitator Superfamily
ES966_04390	COG1846	Transcriptional regulator
ES966_04395	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES966_04395	COG0392	lysyltransferase activity
ES966_04400	COG0384	phenazine biosynthesis protein PhzF
ES966_04405	COG0778	Nitroreductase
ES966_04420	COG1090	epimerase
ES966_04435	COG2814	Major facilitator Superfamily
ES966_04445	COG3591	Belongs to the peptidase S1B family
ES966_04460	COG3103	Sh3 type 3 domain protein
ES966_04465	COG5658	integral membrane protein
ES966_04470	COG0596	Alpha beta hydrolase
ES966_04475	COG0463	Glycosyl transferase, family 2
ES966_04480	COG4485	Bacterial membrane protein, YfhO
ES966_04485	COG1988	membrane-bound metal-dependent
ES966_04490	COG1194	a g-specific adenine glycosylase
ES966_04500	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_04520	COG1132	(ABC) transporter
ES966_04525	COG4129	membrane
ES966_04535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES966_04540	COG0735	belongs to the Fur family
ES966_04680	COG5577	PFAM Coat F domain
ES966_04685	COG3340	Belongs to the peptidase S51 family
ES966_04695	COG0277	FAD linked oxidase domain protein
ES966_04705	COG0747	negative chemotaxis
ES966_04710	COG0601	transmembrane transport
ES966_04715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_04720	COG0444	Belongs to the ABC transporter superfamily
ES966_04725	COG4608	Belongs to the ABC transporter superfamily
ES966_04730	COG0753	catalase activity
ES966_04745	COG1116	anion transmembrane transporter activity
ES966_04750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES966_04755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES966_04780	COG1476	TRANSCRIPTIONal
ES966_04790	COG3382	B3 4 domain protein
ES966_04795	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES966_04805	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES966_04810	COG0789	Transcriptional regulator
ES966_04815	COG1664	Polymer-forming cytoskeletal
ES966_04820	COG1664	Polymer-forming cytoskeletal
ES966_04825	COG2766	serine protein kinase
ES966_04840	COG1846	Transcriptional regulator
ES966_04845	COG1566	PFAM secretion protein HlyD family protein
ES966_04850	COG2814	Major facilitator Superfamily
ES966_04855	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES966_04870	COG1725	Transcriptional regulator
ES966_04875	COG1131	(ABC) transporter
ES966_04880	COG1131	(ABC) transporter
ES966_04885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES966_04895	COG1278	Cold shock
ES966_04905	COG1464	Belongs to the NlpA lipoprotein family
ES966_04910	COG3706	GGDEF domain
ES966_04915	COG1823	symporter activity
ES966_04935	COG5577	PFAM Coat F domain
ES966_04940	COG0737	Belongs to the 5'-nucleotidase family
ES966_04940	COG1525	nuclease
ES966_04940	COG4085	toxin activity
ES966_04945	COG3764	Sortase (surface protein transpeptidase)
ES966_04950	COG0564	pseudouridine synthase activity
ES966_04960	COG0517	IMP dehydrogenase activity
ES966_04965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES966_04970	COG3153	acetyltransferase
ES966_04970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES966_04980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES966_04985	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES966_04990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES966_05000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES966_05010	COG2203	Gaf domain
ES966_05010	COG4585	Histidine kinase
ES966_05020	COG0431	NADPH-dependent FMN reductase
ES966_05035	COG1388	LysM domain
ES966_05035	COG0791	NLP P60 protein
ES966_05040	COG1959	2 iron, 2 sulfur cluster binding
ES966_05050	COG0668	transmembrane transport
ES966_05055	COG2719	SpoVR family
ES966_05060	COG1785	Belongs to the alkaline phosphatase family
ES966_05065	COG0791	NLP P60 protein
ES966_05065	COG1388	LysM domain
ES966_05070	COG0583	DNA-binding transcription factor activity
ES966_05075	COG0372	Belongs to the citrate synthase family
ES966_05080	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_05085	COG0531	amino acid
ES966_05090	COG0733	neurotransmitter:sodium symporter activity
ES966_05105	COG1595	DNA-templated transcription, initiation
ES966_05110	COG0204	Acyl-transferase
ES966_05115	COG1253	flavin adenine dinucleotide binding
ES966_05120	COG0789	Transcriptional regulator
ES966_05125	COG0436	Aminotransferase
ES966_05130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_05135	COG1253	flavin adenine dinucleotide binding
ES966_05140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES966_05145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES966_05150	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_05160	COG0668	transmembrane transport
ES966_05165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES966_05170	COG0726	polysaccharide deacetylase
ES966_05175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_05180	COG3226	Transcriptional regulator
ES966_05190	COG0589	response to stress
ES966_05195	COG1132	(ABC) transporter
ES966_05200	COG1132	(ABC) transporter
ES966_05205	COG0702	epimerase
ES966_05225	COG0189	ligase activity
ES966_05230	COG0189	ligase activity
ES966_05245	COG4335	DNA alkylation repair
ES966_05250	COG0561	phosphatase activity
ES966_05255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES966_05265	COG0475	glutathione-regulated potassium exporter activity
ES966_05270	COG0490	domain, Protein
ES966_05280	COG1024	Enoyl-CoA hydratase
ES966_05290	COG4152	abc transporter atp-binding protein
ES966_05295	COG1668	transmembrane transport
ES966_05300	COG0420	3'-5' exonuclease activity
ES966_05305	COG4717	serine-type aminopeptidase activity
ES966_05320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES966_05360	COG4980	gas vesicle protein
ES966_05375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES966_05380	COG0537	adenosine 5'-monophosphoramidase activity
ES966_05385	COG1131	(ABC) transporter
ES966_05390	COG4473	ABC transporter
ES966_05400	COG1473	amidohydrolase
ES966_05405	COG3069	C4-dicarboxylate transmembrane transporter activity
ES966_05410	COG2329	Antibiotic biosynthesis monooxygenase
ES966_05415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES966_05435	COG1309	transcriptional regulator
ES966_05440	COG1511	domain protein
ES966_05445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_05455	COG1363	Peptidase, m42
ES966_05460	COG1301	dicarboxylic acid transport
ES966_05470	COG1234	tRNA 3'-trailer cleavage
ES966_05475	COG0095	Lipoate-protein ligase
ES966_05480	COG0702	epimerase
ES966_05485	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_05495	COG0501	Belongs to the peptidase M48B family
ES966_05500	COG1404	Belongs to the peptidase S8 family
ES966_05515	COG0406	alpha-ribazole phosphatase activity
ES966_05520	COG0183	Belongs to the thiolase family
ES966_05525	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_05530	COG1268	BioY protein
ES966_05540	COG0723	plastoquinol--plastocyanin reductase activity
ES966_05540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES966_05545	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_05555	COG4903	ComK protein
ES966_05565	COG5646	InterPro IPR014922
ES966_05590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES966_05605	COG0398	Pfam SNARE associated Golgi protein
ES966_05610	COG0681	Belongs to the peptidase S26 family
ES966_05615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES966_05620	COG1846	Transcriptional regulator
ES966_05630	COG2814	Major facilitator Superfamily
ES966_05640	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES966_05645	COG2323	membrane
ES966_05660	COG0420	3'-5' exonuclease activity
ES966_05665	COG0419	ATPase involved in DNA repair
ES966_05670	COG1403	HNH endonuclease
ES966_05715	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES966_05730	COG0367	asparagine synthase
ES966_05740	COG0534	Mate efflux family protein
ES966_05745	COG2207	Transcriptional regulator
ES966_05745	COG1917	Cupin 2, conserved barrel domain protein
ES966_05750	COG1609	Transcriptional regulator
ES966_05755	COG0673	inositol 2-dehydrogenase activity
ES966_05760	COG2318	DinB family
ES966_05765	COG1279	arginine transmembrane transporter activity
ES966_05770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_05775	COG1357	PFAM Pentapeptide repeats (8 copies)
ES966_05780	COG2153	protein acetylation
ES966_05785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES966_05785	COG0646	methionine synthase
ES966_05795	COG2996	Protein conserved in bacteria
ES966_05805	COG0840	transmembrane signaling receptor activity
ES966_05810	COG2124	cytochrome p450
ES966_05820	COG1307	EDD domain protein, DegV family
ES966_05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_05840	COG0561	phosphatase activity
ES966_05845	COG1073	alpha beta
ES966_05850	COG2151	metal-sulfur cluster biosynthetic enzyme
ES966_05860	COG0277	FAD linked oxidase domain protein
ES966_05865	COG2271	Major facilitator Superfamily
ES966_05885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES966_05895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES966_05900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES966_05935	COG1744	ABC transporter substrate-binding protein PnrA-like
ES966_05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_05955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES966_05960	COG5504	Zn-dependent protease
ES966_05965	COG0444	Belongs to the ABC transporter superfamily
ES966_05970	COG4608	Belongs to the ABC transporter superfamily
ES966_05980	COG0601	transmembrane transport
ES966_05985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_05995	COG0180	Tryptophanyl-tRNA synthetase
ES966_06000	COG4166	transmembrane transport
ES966_06005	COG0601	transmembrane transport
ES966_06010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_06015	COG0444	Belongs to the ABC transporter superfamily
ES966_06020	COG4608	Belongs to the ABC transporter superfamily
ES966_06030	COG0456	acetyltransferase
ES966_06035	COG1393	Belongs to the ArsC family
ES966_06040	COG0861	Integral membrane protein TerC family
ES966_06045	COG4862	establishment of competence for transformation
ES966_06050	COG4469	Competence protein
ES966_06055	COG1164	Oligoendopeptidase f
ES966_06065	COG2346	COG2346, Truncated hemoglobins
ES966_06070	COG0741	lytic transglycosylase activity
ES966_06075	COG4116	CYTH
ES966_06085	COG2357	RelA SpoT domain protein
ES966_06095	COG0564	pseudouridine synthase activity
ES966_06105	COG0569	domain protein
ES966_06105	COG0475	glutathione-regulated potassium exporter activity
ES966_06110	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES966_06115	COG0352	thiamine-phosphate diphosphorylase activity
ES966_06120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES966_06125	COG2104	thiamine diphosphate biosynthetic process
ES966_06135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES966_06140	COG0351	phosphomethylpyrimidine kinase
ES966_06145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES966_06200	COG0210	DNA helicase
ES966_06220	COG1131	(ABC) transporter
ES966_06230	COG2153	protein acetylation
ES966_06240	COG2382	esterase
ES966_06245	COG0626	cystathionine gamma-synthase activity
ES966_06250	COG0626	cystathionine gamma-synthase activity
ES966_06330	COG3655	Transcriptional regulator
ES966_06370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_06370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_06410	COG1780	Probably involved in ribonucleotide reductase function
ES966_06415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES966_06420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES966_06425	COG0756	dUTP diphosphatase activity
ES966_06435	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ES966_06440	COG3584	3D domain protein
ES966_06480	COG1793	dna ligase
ES966_06535	COG0582	viral genome integration into host DNA
ES966_06620	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_06630	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_06650	COG4824	toxin secretion phage lysis holin
ES966_06655	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_06655	COG3409	Peptidoglycan-binding domain 1 protein
ES966_06690	COG0582	viral genome integration into host DNA
ES966_06790	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES966_06845	COG3328	transposase activity
ES966_06920	COG5444	nuclease activity
ES966_06950	COG2367	Beta-lactamase
ES966_06955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES966_06960	COG0477	Major facilitator Superfamily
ES966_06965	COG1846	Transcriptional regulator
ES966_06980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES966_06985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES966_06990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_06990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_06995	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES966_07025	COG1285	pathogenesis
ES966_07040	COG2205	protein histidine kinase activity
ES966_07050	COG3383	formate dehydrogenase (NAD+) activity
ES966_07055	COG2427	Protein of unknown function (DUF1641)
ES966_07060	COG2124	cytochrome p450
ES966_07075	COG1587	Uroporphyrinogen-III synthase
ES966_07080	COG0390	transport system, permease component
ES966_07085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES966_07090	COG0697	spore germination
ES966_07095	COG4297	protein containing double-stranded beta helix domain
ES966_07105	COG1252	NADH dehydrogenase
ES966_07120	COG1609	Transcriptional regulator
ES966_07125	COG0246	Mannitol dehydrogenase
ES966_07130	COG2721	sulfolactate sulfo-lyase activity
ES966_07135	COG0745	RESPONSE REGULATOR receiver
ES966_07140	COG2770	Histidine kinase
ES966_07140	COG2205	protein histidine kinase activity
ES966_07160	COG4585	Histidine kinase
ES966_07165	COG2197	response regulator
ES966_07195	COG0730	response to heat
ES966_07200	COG2318	DinB family
ES966_07205	COG0457	Tetratricopeptide repeat
ES966_07210	COG1388	LysM domain
ES966_07210	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_07210	COG3409	Peptidoglycan-binding domain 1 protein
ES966_07220	COG4195	phage-related replication protein
ES966_07225	COG2856	Zn peptidase
ES966_07230	COG1396	sequence-specific DNA binding
ES966_07240	COG1522	sequence-specific DNA binding
ES966_07245	COG1484	DNA-dependent DNA replication
ES966_07260	COG1595	DNA-templated transcription, initiation
ES966_07265	COG4193	domain, Protein
ES966_07300	COG3409	Peptidoglycan-binding domain 1 protein
ES966_07300	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_07315	COG0306	phosphate transporter
ES966_07320	COG1392	Phosphate transport regulator
ES966_07325	COG0531	amino acid
ES966_07330	COG0346	lactoylglutathione lyase activity
ES966_07335	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES966_07340	COG0463	Glycosyl transferase, family 2
ES966_07345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_07350	COG0477	Major facilitator Superfamily
ES966_07355	COG2362	D-Aminopeptidase
ES966_07360	COG0601	transmembrane transport
ES966_07365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES966_07370	COG0444	Belongs to the ABC transporter superfamily
ES966_07375	COG4166	transmembrane transport
ES966_07380	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES966_07385	COG4948	Mandelate Racemase Muconate Lactonizing
ES966_07390	COG0791	NLP P60 protein
ES966_07395	COG4608	Belongs to the ABC transporter superfamily
ES966_07400	COG2706	6-phosphogluconolactonase activity
ES966_07405	COG1834	amidinotransferase
ES966_07410	COG1607	acyl-coa hydrolase
ES966_07415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_07420	COG2076	Multidrug Resistance protein
ES966_07425	COG2076	Multidrug Resistance protein
ES966_07430	COG0788	formyltetrahydrofolate deformylase activity
ES966_07435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES966_07445	COG1764	response to oxidative stress
ES966_07450	COG1846	Transcriptional regulator
ES966_07455	COG1764	response to oxidative stress
ES966_07470	COG0457	Tetratricopeptide repeat
ES966_07470	COG0463	Glycosyl transferase, family 2
ES966_07480	COG2814	Major facilitator Superfamily
ES966_07485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES966_07495	COG1404	Belongs to the peptidase S8 family
ES966_07500	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_07505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES966_07510	COG1122	ATPase activity
ES966_07515	COG4721	ABC-type cobalt transport system, permease component
ES966_07520	COG1388	LysM domain
ES966_07520	COG3858	chitin binding
ES966_07540	COG2239	Acts as a magnesium transporter
ES966_07545	COG0789	Transcriptional regulator
ES966_07560	COG1846	Transcriptional regulator
ES966_07565	COG0726	polysaccharide deacetylase
ES966_07570	COG3285	dna ligase
ES966_07570	COG1793	dna ligase
ES966_07575	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES966_07580	COG0586	Pfam SNARE associated Golgi protein
ES966_07585	COG0861	Integral membrane protein TerC family
ES966_07590	COG1191	sigma factor activity
ES966_07615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES966_07620	COG2323	membrane
ES966_07635	COG5002	protein histidine kinase activity
ES966_07640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES966_07655	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES966_07660	COG0436	Aminotransferase
ES966_07690	COG3852	Histidine kinase
ES966_07695	COG1846	Transcriptional regulator
ES966_07700	COG1360	Flagellar Motor Protein
ES966_07705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES966_07710	COG0542	response to heat
ES966_07720	COG3949	Membrane
ES966_07735	COG0720	synthase
ES966_07740	COG0602	queuosine metabolic process
ES966_07745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES966_07750	COG1733	regulation of RNA biosynthetic process
ES966_07755	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_07775	COG4873	Protein conserved in bacteria
ES966_07785	COG3773	Cell wall hydrolase
ES966_07790	COG2244	polysaccharide biosynthetic process
ES966_07795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_07800	COG2217	Heavy metal translocating P-type atpase
ES966_07805	COG0006	proline dipeptidase activity
ES966_07810	COG1609	Transcriptional regulator
ES966_07815	COG3711	transcriptional antiterminator
ES966_07820	COG2190	(PTS) system
ES966_07820	COG1263	PTS System
ES966_07820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_07825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_07830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES966_07840	COG1533	DNA photolyase activity
ES966_07845	COG0840	transmembrane signaling receptor activity
ES966_07850	COG2084	Dehydrogenase
ES966_07855	COG2340	Cysteine-rich secretory protein family
ES966_07860	COG0768	penicillin binding
ES966_07865	COG4191	Histidine kinase
ES966_07870	COG0436	Aminotransferase
ES966_07880	COG0835	chemotaxis
ES966_07880	COG0784	Response regulator, receiver
ES966_07895	COG1376	ErfK ybiS ycfS ynhG family protein
ES966_07900	COG1408	metallophosphoesterase
ES966_07905	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_07915	COG2200	EAL domain
ES966_07920	COG4703	Protein of unknown function (DUF1797)
ES966_07925	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES966_07935	COG0517	IMP dehydrogenase activity
ES966_07940	COG0583	DNA-binding transcription factor activity
ES966_07955	COG0716	FMN binding
ES966_07975	COG0668	transmembrane transport
ES966_07980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_08000	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES966_08005	COG0303	'Molybdopterin
ES966_08010	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES966_08015	COG0314	molybdopterin synthase activity
ES966_08020	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES966_08030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES966_08035	COG1136	(ABC) transporter
ES966_08040	COG0577	efflux transmembrane transporter activity
ES966_08045	COG1349	DNA-binding transcription factor activity
ES966_08050	COG1105	Belongs to the carbohydrate kinase PfkB family
ES966_08055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_08055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_08055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_08060	COG0681	Belongs to the peptidase S26 family
ES966_08070	COG0488	(ABC) transporter
ES966_08075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES966_08080	COG2309	aminopeptidase activity
ES966_08090	COG1077	Cell shape determining protein MreB Mrl
ES966_08100	COG2002	toxin-antitoxin pair type II binding
ES966_08105	COG3852	Histidine kinase
ES966_08110	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ES966_08110	COG2105	PFAM AIG2 family protein
ES966_08115	COG0569	domain protein
ES966_08125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES966_08135	COG0561	phosphatase activity
ES966_08140	COG0242	peptide deformylase activity
ES966_08150	COG0497	DNA recombination
ES966_08170	COG4221	oxidoreductase activity
ES966_08170	COG3321	synthase
ES966_08170	COG0300	oxidoreductase activity
ES966_08170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_08175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_08175	COG4221	oxidoreductase activity
ES966_08175	COG3321	synthase
ES966_08175	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_08185	COG0300	oxidoreductase activity
ES966_08185	COG3321	synthase
ES966_08185	COG4221	oxidoreductase activity
ES966_08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_08195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_08195	COG3321	synthase
ES966_08195	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_08195	COG4221	oxidoreductase activity
ES966_08200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES966_08205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES966_08210	COG0022	dehydrogenase e1 component
ES966_08215	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_08220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES966_08225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_08240	COG1982	Orn Lys Arg decarboxylase major
ES966_08265	COG0483	inositol monophosphate 1-phosphatase activity
ES966_08275	COG3227	Zinc metalloprotease (Elastase)
ES966_08290	COG1595	DNA-templated transcription, initiation
ES966_08320	COG4896	Protein conserved in bacteria
ES966_08330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES966_08335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES966_08340	COG2066	Belongs to the glutaminase family
ES966_08350	COG0772	Belongs to the SEDS family
ES966_08355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES966_08370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES966_08370	COG2010	Cytochrome c
ES966_08375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES966_08380	COG1845	cytochrome c oxidase, subunit III
ES966_08385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES966_08390	COG3336	cytochrome c oxidase
ES966_08400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES966_08405	COG2340	Cysteine-rich secretory protein family
ES966_08420	COG3679	Belongs to the UPF0342 family
ES966_08435	COG0742	ribosomal rna small subunit methyltransferase
ES966_08445	COG3314	Sporulation integral membrane protein YlbJ
ES966_08450	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES966_08455	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES966_08465	COG1399	metal-binding, possibly nucleic acid-binding protein
ES966_08470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ES966_08485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES966_08505	COG4839	cell division protein FtsL
ES966_08515	COG0768	penicillin binding
ES966_08535	COG0772	Belongs to the SEDS family
ES966_08550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES966_08560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES966_08575	COG1191	sigma factor activity
ES966_08580	COG1191	sigma factor activity
ES966_08585	COG1119	ATPase activity
ES966_08590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_08605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES966_08615	COG0762	integral membrane protein
ES966_08620	COG2302	S4 RNA-binding domain
ES966_08625	COG3599	regulation of cell shape
ES966_08635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES966_08640	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES966_08650	COG0564	pseudouridine synthase activity
ES966_08660	COG2233	PERMEase
ES966_08670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES966_08675	COG0505	Belongs to the CarA family
ES966_08680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES966_08695	COG0284	orotidine-5'-phosphate decarboxylase activity
ES966_08700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES966_08710	COG0306	phosphate transporter
ES966_08725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES966_08730	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES966_08735	COG1648	precorrin-2 dehydrogenase activity
ES966_08750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES966_08755	COG1561	YicC-like family, N-terminal region
ES966_08760	COG2052	Domain of unknown function (DUF370)
ES966_08765	COG0194	GDP metabolic process
ES966_08775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES966_08780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES966_08785	COG0242	peptide deformylase activity
ES966_08795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES966_08795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES966_08805	COG0631	protein serine/threonine phosphatase activity
ES966_08810	COG0515	serine threonine protein kinase
ES966_08810	COG2815	serine threonine protein kinase
ES966_08820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES966_08825	COG1564	THIamine pyrophosphokinase
ES966_08840	COG1302	Protein conserved in bacteria
ES966_08845	COG1461	Dihydroxyacetone kinase
ES966_08850	COG1760	l-serine dehydratase
ES966_08855	COG1760	l-serine dehydratase
ES966_08860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES966_08875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES966_08880	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_08885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_08895	COG1196	nuclear chromosome segregation
ES966_08915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES966_08925	COG1837	Belongs to the UPF0109 family
ES966_08950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES966_08965	COG2257	FlhB HrpN YscU SpaS Family
ES966_08975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES966_08980	COG0758	DNA mediated transformation
ES966_08985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES966_08995	COG4974	Belongs to the 'phage' integrase family
ES966_09015	COG1815	bacterial-type flagellum-dependent cell motility
ES966_09020	COG1558	bacterial-type flagellum-dependent cell motility
ES966_09025	COG1677	Flagellar hook-basal body complex protein FliE
ES966_09030	COG1766	The M ring may be actively involved in energy transduction
ES966_09035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES966_09040	COG1317	bacterial-type flagellum organization
ES966_09045	COG1157	protein secretion by the type III secretion system
ES966_09050	COG2882	bacterial-type flagellum organization
ES966_09055	COG3334	PFAM MgtE intracellular
ES966_09060	COG3144	bacterial-type flagellum assembly
ES966_09065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES966_09070	COG4786	Flagellar basal body rod
ES966_09075	COG1582	Flagellar protein (FlbD)
ES966_09080	COG1580	Controls the rotational direction of flagella during chemotaxis
ES966_09085	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES966_09090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES966_09090	COG1776	CheC inhibitor of MCP methylation
ES966_09095	COG2201	protein-glutamate methylesterase activity
ES966_09100	COG3190	flagellar
ES966_09105	COG1338	Plays a role in the flagellum-specific transport system
ES966_09110	COG1987	bacterial-type flagellum assembly
ES966_09115	COG1684	flagellar biosynthetic protein fliR
ES966_09120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES966_09125	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES966_09130	COG1419	protein localization to endoplasmic reticulum
ES966_09135	COG0455	bacterial-type flagellum organization
ES966_09140	COG2201	protein-glutamate methylesterase activity
ES966_09145	COG2198	Histidine kinase
ES966_09145	COG0643	Histidine kinase
ES966_09150	COG0835	chemotaxis
ES966_09155	COG1776	CheC inhibitor of MCP methylation
ES966_09165	COG1191	sigma factor activity
ES966_09195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES966_09200	COG4589	Belongs to the CDS family
ES966_09210	COG0750	zinc metalloprotease
ES966_09230	COG0195	Participates in both transcription termination and antitermination
ES966_09235	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES966_09240	COG1358	cellular component organization or biogenesis
ES966_09250	COG1550	Protein conserved in bacteria
ES966_09265	COG0196	riboflavin kinase activity
ES966_09280	COG0726	polysaccharide deacetylase
ES966_09285	COG0612	Peptidase, M16
ES966_09290	COG1873	PFAM PRC-barrel domain
ES966_09295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES966_09300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES966_09305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES966_09310	COG0527	aspartate kinase activity
ES966_09320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES966_09325	COG0740	serine-type endopeptidase activity
ES966_09335	COG4980	gas vesicle protein
ES966_09335	COG1674	ftsk spoiiie
ES966_09340	COG2188	Transcriptional regulator
ES966_09345	COG2814	Major facilitator Superfamily
ES966_09350	COG1846	Transcriptional regulator
ES966_09355	COG1033	growth of symbiont in host cell
ES966_09355	COG2409	Drug exporters of the RND superfamily
ES966_09360	COG0612	Peptidase, M16
ES966_09365	COG0612	Peptidase, M16
ES966_09370	COG0300	oxidoreductase activity
ES966_09390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES966_09415	COG1692	metallophosphoesterase
ES966_09420	COG2359	stage V sporulation protein S
ES966_09440	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES966_09505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_09510	COG3425	synthase
ES966_09515	COG1024	Enoyl-CoA hydratase
ES966_09525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_09525	COG4221	oxidoreductase activity
ES966_09525	COG0300	oxidoreductase activity
ES966_09525	COG3321	synthase
ES966_09545	COG3321	synthase
ES966_09545	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES966_09545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_09545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ES966_09550	COG2124	cytochrome p450
ES966_09555	COG3209	COG3209 Rhs family protein
ES966_09560	COG3619	membrane
ES966_09570	COG1404	Belongs to the peptidase S8 family
ES966_09580	COG4195	phage-related replication protein
ES966_09585	COG1764	response to oxidative stress
ES966_09595	COG2076	Multidrug Resistance protein
ES966_09635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES966_09645	COG4112	unkown
ES966_09660	COG0464	growth
ES966_09665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES966_09670	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES966_09675	COG0789	Transcriptional regulator
ES966_09680	COG0174	glutamine synthetase
ES966_09710	COG2211	Major facilitator Superfamily
ES966_09715	COG3507	Belongs to the glycosyl hydrolase 43 family
ES966_09735	COG0574	Belongs to the PEP-utilizing enzyme family
ES966_09735	COG3848	Pyruvate phosphate dikinase
ES966_09760	COG2378	regulation of single-species biofilm formation
ES966_09765	COG2318	DinB family
ES966_09770	COG1064	alcohol dehydrogenase
ES966_09795	COG0456	acetyltransferase
ES966_09800	COG5444	nuclease activity
ES966_09865	COG3397	chitin binding
ES966_09885	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_09890	COG0756	dUTP diphosphatase activity
ES966_09895	COG4195	phage-related replication protein
ES966_09935	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES966_09955	COG0785	Cytochrome C biogenesis protein
ES966_09960	COG2201	protein-glutamate methylesterase activity
ES966_09965	COG4846	Membrane protein involved in cytochrome C biogenesis
ES966_09975	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_09990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES966_09995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_10015	COG0824	Thioesterase
ES966_10025	COG4841	protein insertion into membrane
ES966_10035	COG1832	CoA-binding protein
ES966_10040	COG0187	DNA topoisomerase II activity
ES966_10045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES966_10055	COG1115	amino acid carrier protein
ES966_10065	COG1063	alcohol dehydrogenase
ES966_10070	COG0800	Aldolase
ES966_10075	COG1312	Catalyzes the dehydration of D-mannonate
ES966_10080	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_10085	COG1609	Transcriptional regulator
ES966_10090	COG2271	Major facilitator Superfamily
ES966_10135	COG2205	protein histidine kinase activity
ES966_10140	COG0745	RESPONSE REGULATOR receiver
ES966_10150	COG3507	Belongs to the glycosyl hydrolase 43 family
ES966_10175	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_10180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES966_10185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES966_10190	COG2610	gluconate transmembrane transporter activity
ES966_10195	COG2124	cytochrome p450
ES966_10200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ES966_10215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES966_10225	COG2246	polysaccharide biosynthetic process
ES966_10230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES966_10235	COG0586	Pfam SNARE associated Golgi protein
ES966_10240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES966_10245	COG1024	Enoyl-CoA hydratase
ES966_10250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES966_10255	COG0511	ligase activity, forming carbon-carbon bonds
ES966_10260	COG0439	Biotin carboxylase
ES966_10265	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_10270	COG1960	acyl-CoA dehydrogenase activity
ES966_10275	COG1649	PFAM Uncharacterised BCR, COG1649
ES966_10285	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES966_10285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_10300	COG2323	membrane
ES966_10315	COG2323	membrane
ES966_10330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_10375	COG2027	D-alanyl-D-alanine carboxypeptidase
ES966_10385	COG0534	Mate efflux family protein
ES966_10400	COG0582	viral genome integration into host DNA
ES966_10405	COG0166	Belongs to the GPI family
ES966_10410	COG0405	Gamma-glutamyltransferase
ES966_10420	COG0640	Transcriptional regulator
ES966_10425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES966_10435	COG0604	alcohol dehydrogenase
ES966_10445	COG0493	'glutamate synthase
ES966_10450	COG0069	glutamate synthase activity
ES966_10450	COG0067	glutamate synthase
ES966_10450	COG0070	glutamate synthase
ES966_10455	COG0583	DNA-binding transcription factor activity
ES966_10460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES966_10475	COG0300	oxidoreductase activity
ES966_10480	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES966_10490	COG2814	Major facilitator Superfamily
ES966_10495	COG1070	Carbohydrate kinase
ES966_10505	COG0243	molybdopterin cofactor binding
ES966_10535	COG5444	nuclease activity
ES966_10540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_10545	COG0662	Cupin 2, conserved barrel domain protein
ES966_10545	COG2207	Transcriptional regulator
ES966_10550	COG1309	transcriptional regulator
ES966_10555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_10565	COG0640	Transcriptional regulator
ES966_10570	COG0741	lytic transglycosylase activity
ES966_10575	COG2322	membrane
ES966_10590	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES966_10600	COG3584	3D domain protein
ES966_10600	COG1388	LysM domain
ES966_10605	COG0514	ATP-dependent DNA helicase (RecQ)
ES966_10615	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES966_10620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES966_10635	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_10665	COG1012	belongs to the aldehyde dehydrogenase family
ES966_10670	COG1657	PFAM Prenyltransferase squalene oxidase
ES966_10675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES966_10680	COG0733	neurotransmitter:sodium symporter activity
ES966_10685	COG0385	Bile acid
ES966_10690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_10695	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_10705	COG4548	von Willebrand factor, type A
ES966_10710	COG0714	Associated with various cellular activities
ES966_10715	COG2032	superoxide dismutase activity
ES966_10720	COG0791	NLP P60 protein
ES966_10720	COG1388	LysM domain
ES966_10725	COG1819	glycosyl
ES966_10730	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES966_10735	COG0534	Mate efflux family protein
ES966_10740	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_10745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES966_10750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES966_10760	COG2962	Rard protein
ES966_10775	COG1942	4-Oxalocrotonate Tautomerase
ES966_10785	COG1733	regulation of RNA biosynthetic process
ES966_10790	COG0778	Nitroreductase
ES966_10795	COG0400	carboxylic ester hydrolase activity
ES966_10800	COG0346	lactoylglutathione lyase activity
ES966_10810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES966_10820	COG2723	6-phospho-beta-galactosidase activity
ES966_10825	COG2188	Transcriptional regulator
ES966_10830	COG3409	Peptidoglycan-binding domain 1 protein
ES966_10830	COG0793	Belongs to the peptidase S41A family
ES966_10835	COG2226	methyltransferase
ES966_10845	COG1876	peptidase activity
ES966_10865	COG0671	phosphoesterase, PA-phosphatase related
ES966_10895	COG1509	lysine 2,3-aminomutase activity
ES966_10900	COG0456	acetyltransferase
ES966_10905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_10910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES966_10915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES966_10920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES966_10935	COG0456	acetyltransferase
ES966_10940	COG0463	Glycosyl transferase, family 2
ES966_10955	COG4641	Protein conserved in bacteria
ES966_10965	COG1086	Polysaccharide biosynthesis protein
ES966_10980	COG1846	Transcriptional regulator
ES966_10985	COG4698	Protein conserved in bacteria
ES966_10990	COG2755	lipolytic protein G-D-S-L family
ES966_10995	COG1999	signal sequence binding
ES966_11005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES966_11010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES966_11015	COG1272	protein, Hemolysin III
ES966_11020	COG0204	Acyl-transferase
ES966_11025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES966_11040	COG2521	methyltransferase
ES966_11040	COG2136	Putative SAM-dependent methyltransferase
ES966_11055	COG1413	lyase activity
ES966_11060	COG1418	mRNA catabolic process
ES966_11065	COG0386	Belongs to the glutathione peroxidase family
ES966_11075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES966_11085	COG1278	Cold shock
ES966_11105	COG0328	RNA-DNA hybrid ribonuclease activity
ES966_11110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES966_11115	COG0328	RNA-DNA hybrid ribonuclease activity
ES966_11125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_11170	COG1335	isochorismatase
ES966_11180	COG2233	PERMEase
ES966_11190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES966_11195	COG1199	ATP-dependent helicase activity
ES966_11210	COG0116	Belongs to the methyltransferase superfamily
ES966_11240	COG3359	exonuclease
ES966_11245	COG1111	helicase
ES966_11245	COG1205	dead DEAH box helicase
ES966_11250	COG2190	(PTS) system
ES966_11255	COG0071	Belongs to the small heat shock protein (HSP20) family
ES966_11295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES966_11295	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES966_11305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES966_11310	COG3935	DnaD domain protein
ES966_11320	COG0436	Aminotransferase
ES966_11325	COG5353	protein conserved in bacteria
ES966_11335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES966_11335	COG1199	ATP-dependent helicase activity
ES966_11365	COG0438	transferase activity, transferring glycosyl groups
ES966_11370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES966_11385	COG1694	Mazg nucleotide pyrophosphohydrolase
ES966_11390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_11395	COG2140	Oxalate decarboxylase
ES966_11405	COG4347	Protein of unknown function (DUF1405)
ES966_11410	COG2010	Cytochrome c
ES966_11410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES966_11415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES966_11435	COG0457	Tetratricopeptide repeat
ES966_11445	COG0287	Prephenate dehydrogenase
ES966_11480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES966_11485	COG4401	Chorismate mutase type I
ES966_11500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES966_11505	COG0105	UTP biosynthetic process
ES966_11510	COG0142	geranyltranstransferase activity
ES966_11520	COG0142	geranyltranstransferase activity
ES966_11535	COG0776	regulation of translation
ES966_11580	COG0539	negative regulation of cytoplasmic translation
ES966_11590	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES966_11595	COG2959	enzyme of heme biosynthesis
ES966_11600	COG3409	Peptidoglycan-binding domain 1 protein
ES966_11600	COG3773	Cell wall hydrolase
ES966_11610	COG0492	ferredoxin-NADP+ reductase activity
ES966_11615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES966_11620	COG4862	establishment of competence for transformation
ES966_11625	COG1408	metallophosphoesterase
ES966_11635	COG1388	LysM domain
ES966_11640	COG1266	CAAX protease self-immunity
ES966_11645	COG0514	ATP-dependent DNA helicase (RecQ)
ES966_11650	COG4955	Helix-turn-helix domain
ES966_11655	COG1141	Ferredoxin
ES966_11660	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES966_11665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES966_11675	COG1595	DNA-templated transcription, initiation
ES966_11680	COG5002	protein histidine kinase activity
ES966_11685	COG0745	RESPONSE REGULATOR receiver
ES966_11690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES966_11695	COG1333	cytochrome c biogenesis protein
ES966_11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_11705	COG1187	pseudouridine synthase activity
ES966_11710	COG0700	Nucleoside recognition
ES966_11715	COG2715	membrane protein required for spore maturation
ES966_11720	COG1686	Belongs to the peptidase S11 family
ES966_11745	COG1547	Domain of unknown function (DUF309)
ES966_11755	COG0456	acetyltransferase
ES966_11770	COG0307	riboflavin synthase, alpha
ES966_11775	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES966_11775	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES966_11785	COG0681	Belongs to the peptidase S26 family
ES966_11795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES966_11800	COG4086	secreted protein
ES966_11805	COG0019	diaminopimelate decarboxylase activity
ES966_11810	COG0697	spore germination
ES966_11825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES966_11845	COG1191	sigma factor activity
ES966_11855	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_11860	COG1686	Belongs to the peptidase S11 family
ES966_11865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES966_11870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES966_11875	COG4974	Belongs to the 'phage' integrase family
ES966_11885	COG0735	belongs to the Fur family
ES966_11890	COG1300	Membrane
ES966_11905	COG0281	malic enzyme
ES966_11910	COG1757	Na H antiporter
ES966_11915	COG1027	Aspartate ammonia-lyase
ES966_11925	COG1396	sequence-specific DNA binding
ES966_11930	COG1379	DNA repair
ES966_11935	COG0494	nUDIX hydrolase
ES966_11945	COG0667	Aldo Keto reductase
ES966_11955	COG1073	alpha beta
ES966_11965	COG4918	Iron-sulphur cluster biosynthesis
ES966_11970	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES966_11970	COG0456	acetyltransferase
ES966_11975	COG2329	Antibiotic biosynthesis monooxygenase
ES966_11980	COG0456	acetyltransferase
ES966_11985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES966_12000	COG0628	permease
ES966_12010	COG0346	lactoylglutathione lyase activity
ES966_12020	COG3048	D-serine ammonia-lyase activity
ES966_12025	COG0300	oxidoreductase activity
ES966_12030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_12035	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES966_12045	COG3425	synthase
ES966_12050	COG2124	cytochrome p450
ES966_12065	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_12065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_12065	COG3321	synthase
ES966_12065	COG0300	oxidoreductase activity
ES966_12065	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_12070	COG0300	oxidoreductase activity
ES966_12070	COG3321	synthase
ES966_12070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_12070	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_12070	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_12075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES966_12075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_12075	COG3321	synthase
ES966_12075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_12075	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_12085	COG3321	synthase
ES966_12085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES966_12085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES966_12085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_12085	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_12090	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_12095	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_12110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES966_12110	COG2070	2-Nitropropane dioxygenase
ES966_12115	COG0250	Participates in transcription elongation, termination and antitermination
ES966_12140	COG0596	Alpha beta hydrolase
ES966_12155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES966_12160	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES966_12175	COG0706	membrane insertase activity
ES966_12180	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES966_12185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES966_12190	COG0346	lactoylglutathione lyase activity
ES966_12195	COG1376	ErfK ybiS ycfS ynhG family protein
ES966_12200	COG4129	membrane
ES966_12205	COG1126	abc transporter atp-binding protein
ES966_12210	COG0765	amino acid transport
ES966_12215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_12225	COG1597	lipid kinase activity
ES966_12230	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES966_12235	COG0022	dehydrogenase e1 component
ES966_12240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES966_12245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES966_12250	COG3426	butyrate kinase activity
ES966_12255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES966_12260	COG0280	phosphate acetyltransferase
ES966_12265	COG3290	protein histidine kinase activity
ES966_12265	COG3829	transcription factor binding
ES966_12275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES966_12280	COG2079	MmgE PrpD family protein
ES966_12290	COG1960	acyl-CoA dehydrogenase activity
ES966_12295	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES966_12300	COG0183	Belongs to the thiolase family
ES966_12305	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_12310	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_12330	COG1902	pentaerythritol trinitrate reductase activity
ES966_12345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES966_12350	COG0745	RESPONSE REGULATOR receiver
ES966_12355	COG0750	zinc metalloprotease
ES966_12360	COG0497	DNA recombination
ES966_12370	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES966_12380	COG0142	geranyltranstransferase activity
ES966_12390	COG1570	exodeoxyribonuclease VII activity
ES966_12405	COG1302	Protein conserved in bacteria
ES966_12410	COG0439	Biotin carboxylase
ES966_12415	COG0511	ligase activity, forming carbon-carbon bonds
ES966_12455	COG3854	ATPases associated with a variety of cellular activities
ES966_12470	COG0006	proline dipeptidase activity
ES966_12480	COG3872	metal-dependent enzyme
ES966_12490	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES966_12505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES966_12525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES966_12540	COG1396	sequence-specific DNA binding
ES966_12550	COG0681	Belongs to the peptidase S26 family
ES966_12575	COG4940	Competence protein ComGF
ES966_12585	COG4970	Tfp pilus assembly protein FimT
ES966_12590	COG4537	Required for transformation and DNA binding
ES966_12595	COG1459	type II secretion system
ES966_12600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES966_12610	COG1253	flavin adenine dinucleotide binding
ES966_12615	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_12625	COG1393	Belongs to the ArsC family
ES966_12635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_12645	COG0011	TIGRFAM Protein of
ES966_12655	COG2866	Carboxypeptidase
ES966_12660	COG1940	carbohydrate kinase activity
ES966_12665	COG4483	Protein conserved in bacteria
ES966_12670	COG1757	Na H antiporter
ES966_12680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES966_12685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES966_12695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES966_12700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES966_12705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES966_12710	COG0581	inorganic phosphate transmembrane transporter activity
ES966_12715	COG0573	inorganic phosphate transmembrane transporter activity
ES966_12720	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES966_12730	COG0477	Major facilitator Superfamily
ES966_12735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES966_12740	COG2839	Protein conserved in bacteria
ES966_12745	COG5521	maltodextrose utilization protein MalA
ES966_12750	COG1388	LysM domain
ES966_12760	COG4709	membrane
ES966_12765	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES966_12770	COG0735	belongs to the Fur family
ES966_12775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_12790	COG0513	Belongs to the DEAD box helicase family
ES966_12805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES966_12810	COG2384	SAM-dependent methyltransferase
ES966_12815	COG2010	Cytochrome c
ES966_12820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES966_12825	COG0358	DNA primase activity
ES966_12840	COG0517	IMP dehydrogenase activity
ES966_12845	COG0751	glycine-tRNA ligase activity
ES966_12865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES966_12870	COG0295	cytidine deaminase activity
ES966_12875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES966_12885	COG1480	7TM receptor with intracellular HD hydrolase
ES966_12890	COG1702	phosphate starvation-inducible protein PhoH
ES966_12895	COG0561	phosphatase activity
ES966_12910	COG4864	UPF0365 protein
ES966_12915	COG1030	water channel activity
ES966_12920	COG1610	YqeY-like protein
ES966_12925	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ES966_12930	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES966_12935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES966_12940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES966_12970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES966_12985	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_13000	COG1466	dna polymerase III delta subunit
ES966_13015	COG0658	competence protein
ES966_13015	COG2333	competence protein COMEC
ES966_13020	COG2131	deaminase
ES966_13025	COG1596	polysaccharide export
ES966_13025	COG1555	photosystem II stabilization
ES966_13030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES966_13035	COG2226	methyltransferase
ES966_13040	COG0799	negative regulation of ribosome biogenesis
ES966_13045	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES966_13055	COG1534	Rna-binding protein
ES966_13060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES966_13065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES966_13070	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES966_13080	COG2755	lipolytic protein G-D-S-L family
ES966_13085	COG0726	polysaccharide deacetylase
ES966_13090	COG0398	Pfam SNARE associated Golgi protein
ES966_13125	COG5444	nuclease activity
ES966_13130	COG4282	regulation of fungal-type cell wall biogenesis
ES966_13145	COG3708	Transcriptional regulator
ES966_13145	COG2207	Transcriptional regulator
ES966_13150	COG0583	DNA-binding transcription factor activity
ES966_13165	COG5002	protein histidine kinase activity
ES966_13165	COG0642	Histidine kinase
ES966_13170	COG0745	RESPONSE REGULATOR receiver
ES966_13175	COG2311	Membrane
ES966_13180	COG0454	-acetyltransferase
ES966_13185	COG0563	adenylate kinase activity
ES966_13195	COG2814	Major facilitator Superfamily
ES966_13205	COG0456	acetyltransferase
ES966_13210	COG2318	DinB family
ES966_13220	COG0561	phosphatase activity
ES966_13225	COG0561	phosphatase activity
ES966_13240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_13240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_13240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES966_13245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_13245	COG3711	transcriptional antiterminator
ES966_13255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES966_13260	COG0583	DNA-binding transcription factor activity
ES966_13265	COG2814	Major facilitator Superfamily
ES966_13270	COG2124	cytochrome p450
ES966_13270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES966_13275	COG1309	transcriptional regulator
ES966_13280	COG2226	methyltransferase
ES966_13295	COG2116	formate transmembrane transporter activity
ES966_13300	COG5609	conserved protein (DUF2294)
ES966_13305	COG3383	formate dehydrogenase (NAD+) activity
ES966_13310	COG2427	Protein of unknown function (DUF1641)
ES966_13320	COG0626	cystathionine gamma-synthase activity
ES966_13325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES966_13350	COG0768	penicillin binding
ES966_13380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES966_13405	COG0628	permease
ES966_13410	COG1126	abc transporter atp-binding protein
ES966_13415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_13420	COG0765	amino acid transport
ES966_13425	COG0765	amino acid transport
ES966_13440	COG3881	PFAM PRC-barrel domain
ES966_13445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES966_13450	COG0457	Tetratricopeptide repeat
ES966_13460	COG1104	cysteine desulfurase activity
ES966_13470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES966_13475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES966_13495	COG4991	sh3 domain protein
ES966_13495	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_13495	COG3103	Sh3 type 3 domain protein
ES966_13505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES966_13515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES966_13515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES966_13520	COG5416	Lipopolysaccharide assembly protein A domain
ES966_13525	COG0490	domain, Protein
ES966_13530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES966_13530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES966_13540	COG2244	polysaccharide biosynthetic process
ES966_13545	COG2323	membrane
ES966_13555	COG1862	Preprotein translocase
ES966_13600	COG1388	LysM domain
ES966_13610	COG0157	Belongs to the NadC ModD family
ES966_13615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES966_13620	COG1104	cysteine desulfurase activity
ES966_13625	COG1827	regulation of RNA biosynthetic process
ES966_13630	COG0077	Prephenate dehydratase
ES966_13645	COG3290	protein histidine kinase activity
ES966_13650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES966_13655	COG2868	ribosomal protein
ES966_13665	COG1994	Peptidase M50
ES966_13670	COG0739	heme binding
ES966_13675	COG2894	cell division
ES966_13685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES966_13690	COG1792	Involved in formation and maintenance of cell shape
ES966_13695	COG1077	Cell shape determining protein MreB Mrl
ES966_13715	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES966_13715	COG3409	Peptidoglycan-binding domain 1 protein
ES966_13720	COG4824	toxin secretion phage lysis holin
ES966_13740	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_13745	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_13755	COG3953	SLT domain
ES966_13755	COG5412	phage tail tape measure protein
ES966_13855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_13855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_13895	COG1396	sequence-specific DNA binding
ES966_13925	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES966_13930	COG0285	dihydrofolate synthase activity
ES966_13935	COG0525	valine-tRNA ligase activity
ES966_13945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES966_13950	COG1388	LysM domain
ES966_13960	COG0113	porphobilinogen synthase activity
ES966_13965	COG1587	Uroporphyrinogen-III synthase
ES966_13975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES966_13995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES966_14000	COG0470	DNA polymerase III
ES966_14000	COG1067	ATP-dependent peptidase activity
ES966_14015	COG0457	Tetratricopeptide repeat
ES966_14015	COG1477	protein flavinylation
ES966_14030	COG0473	3-isopropylmalate dehydrogenase activity
ES966_14045	COG0440	acetolactate synthase activity
ES966_14050	COG0028	Belongs to the TPP enzyme family
ES966_14080	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ES966_14105	COG0622	Phosphoesterase
ES966_14110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES966_14120	COG5401	PFAM Sporulation and spore germination
ES966_14135	COG2197	response regulator
ES966_14140	COG0824	Thioesterase
ES966_14145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES966_14150	COG1053	succinate dehydrogenase
ES966_14155	COG2009	succinate dehydrogenase
ES966_14160	COG1719	4-vinyl reductase, 4VR
ES966_14165	COG0527	aspartate kinase activity
ES966_14180	COG3118	belongs to the thioredoxin family
ES966_14185	COG3534	alpha-L-arabinofuranosidase
ES966_14190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES966_14195	COG2086	electron transfer activity
ES966_14200	COG1024	Enoyl-CoA hydratase
ES966_14205	COG1309	transcriptional regulator
ES966_14210	COG0318	PFAM AMP-dependent synthetase and ligase
ES966_14220	COG3766	membrane
ES966_14230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES966_14230	COG1796	DNA polymerase
ES966_14235	COG1286	toxin biosynthetic process
ES966_14250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_14250	COG0072	phenylalanine-tRNA ligase activity
ES966_14255	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES966_14260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES966_14270	COG3835	regulator
ES966_14275	COG0277	FAD linked oxidase domain protein
ES966_14280	COG0247	lactate metabolic process
ES966_14290	COG3534	alpha-L-arabinofuranosidase
ES966_14295	COG0395	ABC-type sugar transport system, permease component
ES966_14300	COG1175	transmembrane transport
ES966_14315	COG0647	UMP catabolic process
ES966_14320	COG0235	Class ii aldolase
ES966_14325	COG1069	ribulokinase activity
ES966_14330	COG2160	L-arabinose isomerase activity
ES966_14335	COG3507	Belongs to the glycosyl hydrolase 43 family
ES966_14340	COG1363	Peptidase, m42
ES966_14350	COG3326	Membrane
ES966_14365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES966_14370	COG1346	cytolysis
ES966_14375	COG1380	Effector of murein hydrolase LrgA
ES966_14380	COG3279	Response regulator of the LytR AlgR family
ES966_14385	COG3275	phosphorelay sensor kinase activity
ES966_14405	COG0398	Pfam SNARE associated Golgi protein
ES966_14410	COG1484	DNA-dependent DNA replication
ES966_14415	COG3611	Membrane attachment protein
ES966_14430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES966_14435	COG1733	regulation of RNA biosynthetic process
ES966_14440	COG2814	Major facilitator Superfamily
ES966_14445	COG0656	L-ascorbic acid biosynthetic process
ES966_14460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES966_14465	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_14465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES966_14470	COG5002	protein histidine kinase activity
ES966_14475	COG0745	RESPONSE REGULATOR receiver
ES966_14485	COG0538	isocitrate dehydrogenase activity
ES966_14490	COG0372	Belongs to the citrate synthase family
ES966_14495	COG0457	Tetratricopeptide repeat
ES966_14525	COG0628	permease
ES966_14530	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES966_14535	COG0469	pyruvate kinase activity
ES966_14555	COG0281	malic enzyme
ES966_14580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES966_14590	COG4109	DRTGG domain
ES966_14600	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_14615	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES966_14625	COG0827	DNA restriction-modification system
ES966_14630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES966_14635	COG3874	Sporulation protein YtfJ
ES966_14645	COG1714	RDD family
ES966_14650	COG0616	signal peptide processing
ES966_14655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES966_14660	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES966_14665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES966_14680	COG1104	cysteine desulfurase activity
ES966_14685	COG1114	Component of the transport system for branched-chain amino acids
ES966_14695	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES966_14700	COG1309	transcriptional regulator
ES966_14725	COG1012	belongs to the aldehyde dehydrogenase family
ES966_14730	COG4282	regulation of fungal-type cell wall biogenesis
ES966_14775	COG1017	nitric oxide dioxygenase activity
ES966_14775	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES966_14790	COG0693	protein deglycase activity
ES966_14805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES966_14810	COG1378	Sugar-specific transcriptional regulator TrmB
ES966_14835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES966_14840	COG0454	-acetyltransferase
ES966_14845	COG0517	IMP dehydrogenase activity
ES966_14850	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES966_14855	COG1360	Flagellar Motor Protein
ES966_14860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES966_14865	COG1609	Transcriptional regulator
ES966_14870	COG1605	Chorismate mutase
ES966_14870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES966_14875	COG3118	belongs to the thioredoxin family
ES966_14880	COG4980	gas vesicle protein
ES966_14885	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES966_14895	COG1674	ftsk spoiiie
ES966_14900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES966_14910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_14930	COG1363	Peptidase, m42
ES966_14935	COG5584	Small secreted protein
ES966_14940	COG0281	malic enzyme
ES966_14945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES966_14960	COG0510	thiamine kinase activity
ES966_14965	COG1597	lipid kinase activity
ES966_14975	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES966_14980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES966_14985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_14990	COG2252	PERMEase
ES966_14995	COG4473	ABC transporter
ES966_15000	COG1131	(ABC) transporter
ES966_15005	COG1349	DNA-binding transcription factor activity
ES966_15010	COG1187	pseudouridine synthase activity
ES966_15015	COG2244	polysaccharide biosynthetic process
ES966_15020	COG2081	HI0933 family
ES966_15060	COG1486	melibiose metabolic process
ES966_15070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES966_15085	COG1366	Belongs to the anti-sigma-factor antagonist family
ES966_15085	COG2202	Pas domain
ES966_15090	COG2814	Major facilitator Superfamily
ES966_15095	COG5522	Integral membrane protein (intg_mem_TP0381)
ES966_15100	COG0577	efflux transmembrane transporter activity
ES966_15105	COG1136	(ABC) transporter
ES966_15110	COG2205	protein histidine kinase activity
ES966_15115	COG0745	RESPONSE REGULATOR receiver
ES966_15120	COG0577	efflux transmembrane transporter activity
ES966_15125	COG1136	(ABC) transporter
ES966_15145	COG1131	(ABC) transporter
ES966_15150	COG1725	Transcriptional regulator
ES966_15170	COG1242	4 iron, 4 sulfur cluster binding
ES966_15175	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES966_15185	COG0584	glycerophosphoryl diester phosphodiesterase
ES966_15195	COG2267	carboxylic ester hydrolase activity
ES966_15200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES966_15205	COG1113	amino acid transport
ES966_15210	COG0367	asparagine synthase
ES966_15230	COG1506	peptidase
ES966_15235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES966_15240	COG1116	anion transmembrane transporter activity
ES966_15245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES966_15250	COG0494	nUDIX hydrolase
ES966_15255	COG4824	toxin secretion phage lysis holin
ES966_15260	COG0783	Belongs to the Dps family
ES966_15285	COG0288	reversible hydration of carbon dioxide
ES966_15295	COG1271	oxidase subunit
ES966_15300	COG1294	oxidase, subunit
ES966_15310	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES966_15315	COG1321	iron dependent repressor
ES966_15315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES966_15320	COG1121	(ABC) transporter
ES966_15325	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES966_15330	COG4948	Mandelate Racemase Muconate Lactonizing
ES966_15340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES966_15345	COG0596	Alpha beta hydrolase
ES966_15355	COG1169	isochorismate synthase
ES966_15360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES966_15365	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES966_15490	COG3859	Proton-coupled thiamine transporter YuaJ
ES966_15495	COG2268	Band 7 protein
ES966_15500	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES966_15505	COG2318	DinB family
ES966_15515	COG1454	alcohol dehydrogenase
ES966_15525	COG1510	regulation of RNA biosynthetic process
ES966_15535	COG0569	domain protein
ES966_15540	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_15545	COG1017	nitric oxide dioxygenase activity
ES966_15545	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES966_15565	COG0457	Tetratricopeptide repeat
ES966_15600	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ES966_15615	COG0628	permease
ES966_15620	COG0673	inositol 2-dehydrogenase activity
ES966_15625	COG0693	protein deglycase activity
ES966_15640	COG0840	transmembrane signaling receptor activity
ES966_15645	COG0840	transmembrane signaling receptor activity
ES966_15660	COG2070	2-Nitropropane dioxygenase
ES966_15665	COG0432	Pfam Uncharacterised protein family UPF0047
ES966_15670	COG0366	Alpha amylase catalytic
ES966_15675	COG1253	flavin adenine dinucleotide binding
ES966_15680	COG2738	Putative neutral zinc metallopeptidase
ES966_15695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES966_15725	COG1335	isochorismatase
ES966_15740	COG2155	Conserved Protein
ES966_15750	COG1098	S1 RNA binding domain
ES966_15755	COG0436	Aminotransferase
ES966_15760	COG1522	sequence-specific DNA binding
ES966_15765	COG2267	carboxylic ester hydrolase activity
ES966_15775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES966_15780	COG2205	protein histidine kinase activity
ES966_15790	COG5018	Exonuclease
ES966_15795	COG2814	Major facilitator Superfamily
ES966_15800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES966_15805	COG3011	Protein conserved in bacteria
ES966_15815	COG3290	protein histidine kinase activity
ES966_15820	COG4565	transcriptional regulatory protein
ES966_15850	COG2111	Na H antiporter
ES966_15850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES966_15855	COG2111	Na H antiporter
ES966_15860	COG1006	Multisubunit Na H antiporter MnhC subunit
ES966_15865	COG0651	ATP synthesis coupled electron transport
ES966_15870	COG1863	multisubunit Na H antiporter MnhE subunit
ES966_15875	COG2212	antiporter activity
ES966_15880	COG1320	monovalent cation:proton antiporter activity
ES966_15885	COG2050	protein possibly involved in aromatic compounds catabolism
ES966_15890	COG2197	response regulator
ES966_15895	COG4585	Histidine kinase
ES966_15905	COG0142	geranyltranstransferase activity
ES966_15925	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES966_15930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES966_15935	COG1335	isochorismatase
ES966_15940	COG5506	Protein of unknown function (DUF1694)
ES966_15955	COG0628	permease
ES966_15965	COG1418	mRNA catabolic process
ES966_15970	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_15990	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES966_15995	COG5417	Belongs to the EsaB family
ES966_16000	COG4842	Belongs to the WXG100 family
ES966_16005	COG2508	Transcriptional regulator
ES966_16005	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES966_16010	COG0686	Belongs to the AlaDH PNT family
ES966_16015	COG5634	Uncharacterized conserved protein (DUF2278)
ES966_16020	COG3251	PFAM MbtH domain protein
ES966_16025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES966_16030	COG1535	isochorismatase
ES966_16030	COG3433	isochorismatase activity
ES966_16035	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES966_16040	COG1169	isochorismate synthase
ES966_16045	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_16050	COG2819	hydrolase of the alpha beta superfamily
ES966_16055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES966_16060	COG1268	BioY protein
ES966_16065	COG2056	Na+-H+ antiporter family
ES966_16075	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES966_16080	COG3584	3D domain protein
ES966_16095	COG1252	NADH dehydrogenase
ES966_16145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES966_16150	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ES966_16155	COG0316	Belongs to the HesB IscA family
ES966_16165	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES966_16180	COG4837	Protein of unknown function (DUF1462)
ES966_16185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES966_16190	COG1506	peptidase
ES966_16190	COG0823	Involved in the tonB-independent uptake of proteins
ES966_16190	COG4946	Tricorn protease homolog
ES966_16200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES966_16205	COG0460	homoserine dehydrogenase
ES966_16210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES966_16215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES966_16220	COG0647	UMP catabolic process
ES966_16225	COG2445	Protein of unknown function DUF86
ES966_16230	COG4470	Protein conserved in bacteria
ES966_16245	COG0739	heme binding
ES966_16255	COG0737	Belongs to the 5'-nucleotidase family
ES966_16260	COG0730	response to heat
ES966_16265	COG1801	Protein of unknown function DUF72
ES966_16280	COG2508	Transcriptional regulator
ES966_16285	COG0457	Tetratricopeptide repeat
ES966_16300	COG2814	Major facilitator Superfamily
ES966_16305	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES966_16310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES966_16315	COG2356	endonuclease I
ES966_16320	COG3842	ATPase activity
ES966_16325	COG2188	Transcriptional regulator
ES966_16330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES966_16335	COG0395	ABC-type sugar transport system, permease component
ES966_16340	COG1175	transmembrane transport
ES966_16345	COG1653	transport
ES966_16350	COG2222	sugar isomerase
ES966_16355	COG0789	Transcriptional regulator
ES966_16380	COG0322	excinuclease ABC activity
ES966_16385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES966_16390	COG2226	methyltransferase
ES966_16405	COG3409	Peptidoglycan-binding domain 1 protein
ES966_16410	COG0719	Fe-S assembly protein
ES966_16415	COG0822	iron-sulfur transferase activity
ES966_16420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES966_16425	COG0719	Fe-S assembly protein
ES966_16430	COG0396	ATPase activity
ES966_16440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES966_16445	COG1464	Belongs to the NlpA lipoprotein family
ES966_16450	COG2011	ABC-type metal ion transport system permease component
ES966_16455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES966_16465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES966_16470	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES966_16485	COG1393	Belongs to the ArsC family
ES966_16490	COG1960	acyl-CoA dehydrogenase activity
ES966_16495	COG0183	Belongs to the thiolase family
ES966_16500	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES966_16500	COG1024	Enoyl-CoA hydratase
ES966_16520	COG5577	PFAM Coat F domain
ES966_16525	COG1846	Transcriptional regulator
ES966_16530	COG0477	Major facilitator Superfamily
ES966_16560	COG1120	ATPase activity
ES966_16575	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_16580	COG0783	Belongs to the Dps family
ES966_16585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_16595	COG0745	RESPONSE REGULATOR receiver
ES966_16600	COG2205	protein histidine kinase activity
ES966_16600	COG2770	Histidine kinase
ES966_16610	COG1309	transcriptional regulator
ES966_16615	COG0114	fumarate hydratase activity
ES966_16625	COG0697	spore germination
ES966_16630	COG0814	amino acid
ES966_16640	COG2197	response regulator
ES966_16650	COG4758	membrane
ES966_16655	COG3595	metallopeptidase activity
ES966_16660	COG1842	Phage shock protein A
ES966_16665	COG4758	membrane
ES966_16670	COG2814	Major facilitator Superfamily
ES966_16675	COG2096	Adenosyltransferase
ES966_16680	COG1120	ATPase activity
ES966_16685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_16690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_16695	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_16700	COG3386	PFAM SMP-30 Gluconolaconase
ES966_16705	COG2205	protein histidine kinase activity
ES966_16710	COG0745	RESPONSE REGULATOR receiver
ES966_16720	COG1191	sigma factor activity
ES966_16730	COG2140	Oxalate decarboxylase
ES966_16740	COG1120	ATPase activity
ES966_16745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_16750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_16760	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES966_16765	COG0531	amino acid
ES966_16780	COG1988	membrane-bound metal-dependent
ES966_16790	COG1910	domain protein
ES966_16795	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES966_16800	COG4149	molybdate abc transporter
ES966_16805	COG2197	response regulator
ES966_16810	COG3850	Histidine kinase
ES966_16815	COG1131	(ABC) transporter
ES966_16825	COG0842	Transport permease protein
ES966_16830	COG0656	L-ascorbic acid biosynthetic process
ES966_16855	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES966_16860	COG3973	AAA domain
ES966_16865	COG2860	membrane
ES966_16875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES966_16880	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES966_16885	COG2217	Heavy metal translocating P-type atpase
ES966_16890	COG2217	Heavy metal translocating P-type atpase
ES966_16895	COG2608	mercury ion transmembrane transporter activity
ES966_16900	COG1937	Protein conserved in bacteria
ES966_16905	COG0673	inositol 2-dehydrogenase activity
ES966_16915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_16920	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ES966_16925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_16930	COG1126	abc transporter atp-binding protein
ES966_16935	COG0765	amino acid transport
ES966_16940	COG0765	amino acid transport
ES966_16945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_16950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES966_16955	COG0454	-acetyltransferase
ES966_16960	COG0583	DNA-binding transcription factor activity
ES966_16965	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_16970	COG2732	(Barnase) inhibitor
ES966_16980	COG2732	(Barnase) inhibitor
ES966_17000	COG4824	toxin secretion phage lysis holin
ES966_17020	COG5434	Belongs to the glycosyl hydrolase 28 family
ES966_17025	COG1388	LysM domain
ES966_17025	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES966_17105	COG4626	Terminase
ES966_17105	COG1802	Transcriptional regulator
ES966_17135	COG0582	viral genome integration into host DNA
ES966_17140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ES966_17265	COG0582	viral genome integration into host DNA
ES966_17280	COG0557	exoribonuclease II activity
ES966_17285	COG1647	Serine aminopeptidase, S33
ES966_17290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES966_17295	COG1476	TRANSCRIPTIONal
ES966_17300	COG1396	sequence-specific DNA binding
ES966_17305	COG1396	sequence-specific DNA binding
ES966_17310	COG1733	regulation of RNA biosynthetic process
ES966_17340	COG1174	glycine betaine transport
ES966_17345	COG1732	Glycine betaine
ES966_17350	COG1174	glycine betaine transport
ES966_17355	COG1125	glycine betaine transport
ES966_17355	COG0517	IMP dehydrogenase activity
ES966_17360	COG1510	regulation of RNA biosynthetic process
ES966_17365	COG1174	glycine betaine transport
ES966_17370	COG1732	Glycine betaine
ES966_17375	COG1174	glycine betaine transport
ES966_17380	COG1125	glycine betaine transport
ES966_17380	COG0517	IMP dehydrogenase activity
ES966_17385	COG1510	regulation of RNA biosynthetic process
ES966_17390	COG2095	MarC family integral membrane protein
ES966_17395	COG3064	Membrane
ES966_17405	COG0456	acetyltransferase
ES966_17425	COG0126	phosphoglycerate kinase activity
ES966_17435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES966_17440	COG2390	Transcriptional regulator
ES966_17450	COG1609	Transcriptional regulator
ES966_17455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_17465	COG0697	spore germination
ES966_17475	COG1113	amino acid transport
ES966_17480	COG1737	Transcriptional regulator
ES966_17485	COG1070	Carbohydrate kinase
ES966_17510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES966_17515	COG2186	Transcriptional regulator
ES966_17520	COG1620	l-lactate permease
ES966_17525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES966_17535	COG5039	Polysaccharide pyruvyl transferase
ES966_17540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES966_17545	COG0110	maltose O-acetyltransferase activity
ES966_17550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES966_17555	COG2244	polysaccharide biosynthetic process
ES966_17560	COG1216	Glycosyl transferase, family 2
ES966_17565	COG5039	Polysaccharide pyruvyl transferase
ES966_17570	COG1216	Glycosyl transferase, family 2
ES966_17580	COG0438	transferase activity, transferring glycosyl groups
ES966_17585	COG1215	transferase activity, transferring glycosyl groups
ES966_17590	COG0438	transferase activity, transferring glycosyl groups
ES966_17595	COG1086	Polysaccharide biosynthesis protein
ES966_17600	COG0489	protein tyrosine kinase activity
ES966_17605	COG3944	biosynthesis protein
ES966_17610	COG1396	sequence-specific DNA binding
ES966_17615	COG2272	Belongs to the type-B carboxylesterase lipase family
ES966_17625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES966_17630	COG2364	Membrane
ES966_17635	COG0456	acetyltransferase
ES966_17640	COG3479	Phenolic acid decarboxylase
ES966_17685	COG1609	Transcriptional regulator
ES966_17695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES966_17700	COG0366	Alpha amylase catalytic
ES966_17705	COG1554	hydrolase, family 65, central catalytic
ES966_17710	COG5521	maltodextrose utilization protein MalA
ES966_17715	COG3833	ABC-type maltose transport systems, permease component
ES966_17720	COG1175	transmembrane transport
ES966_17725	COG2182	Extracellular solute-binding protein
ES966_17730	COG0366	Alpha amylase catalytic
ES966_17735	COG1609	Transcriptional regulator
ES966_17745	COG1694	Mazg nucleotide pyrophosphohydrolase
ES966_17750	COG0659	secondary active sulfate transmembrane transporter activity
ES966_17755	COG0288	reversible hydration of carbon dioxide
ES966_17765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES966_17770	COG4290	ribonuclease
ES966_17775	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES966_17780	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_17790	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES966_17800	COG1051	belongs to the nudix hydrolase family
ES966_17805	COG0492	ferredoxin-NADP+ reductase activity
ES966_17810	COG3883	PFAM NLP P60 protein
ES966_17810	COG0791	NLP P60 protein
ES966_17815	COG0457	Tetratricopeptide repeat
ES966_17820	COG5002	protein histidine kinase activity
ES966_17825	COG0745	RESPONSE REGULATOR receiver
ES966_17830	COG1132	(ABC) transporter
ES966_17835	COG0140	phosphoribosyl-ATP diphosphatase activity
ES966_17835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES966_17860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES966_17875	COG4990	cell redox homeostasis
ES966_17880	COG0110	maltose O-acetyltransferase activity
ES966_17900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES966_17915	COG1309	transcriptional regulator
ES966_17920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES966_17925	COG1950	PFAM Membrane protein of
ES966_17930	COG1983	PspC domain protein
ES966_17935	COG3595	metallopeptidase activity
ES966_17950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES966_17960	COG4897	Protein conserved in bacteria
ES966_17965	COG3848	Pyruvate phosphate dikinase
ES966_17965	COG0574	Belongs to the PEP-utilizing enzyme family
ES966_17970	COG1309	transcriptional regulator
ES966_17975	COG2814	Major facilitator Superfamily
ES966_17990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_18000	COG0793	Belongs to the peptidase S41A family
ES966_18000	COG3409	Peptidoglycan-binding domain 1 protein
ES966_18005	COG3420	alginic acid biosynthetic process
ES966_18010	COG2177	Part of the ABC transporter FtsEX involved in
ES966_18015	COG2884	Cell division ATP-binding protein ftsE
ES966_18020	COG2010	Cytochrome c
ES966_18025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_18040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES966_18055	COG1516	flagellar protein fliS
ES966_18060	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES966_18065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES966_18085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES966_18090	COG4786	Flagellar basal body rod
ES966_18090	COG1256	bacterial-type flagellum assembly
ES966_18095	COG3418	PFAM FlgN family protein
ES966_18100	COG2747	anti-sigma28 factor FlgM
ES966_18110	COG1040	competence protein
ES966_18120	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES966_18125	COG1307	EDD domain protein, DegV family
ES966_18130	COG2197	response regulator
ES966_18135	COG4585	Histidine kinase
ES966_18140	COG1739	Uncharacterized protein family UPF0029
ES966_18145	COG1316	TRANSCRIPTIONal
ES966_18150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES966_18155	COG0438	transferase activity, transferring glycosyl groups
ES966_18160	COG1215	transferase activity, transferring glycosyl groups
ES966_18165	COG3206	protein involved in exopolysaccharide biosynthesis
ES966_18170	COG3307	-O-antigen
ES966_18175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES966_18180	COG0438	transferase activity, transferring glycosyl groups
ES966_18180	COG0297	glycogen (starch) synthase activity
ES966_18185	COG2244	polysaccharide biosynthetic process
ES966_18195	COG2247	cell wall binding repeat
ES966_18195	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES966_18200	COG2385	sporulation resulting in formation of a cellular spore
ES966_18200	COG2247	cell wall binding repeat
ES966_18210	COG1316	TRANSCRIPTIONal
ES966_18220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES966_18225	COG1134	teichoic acid transport
ES966_18240	COG0438	transferase activity, transferring glycosyl groups
ES966_18245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ES966_18250	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ES966_18255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES966_18265	COG1482	cell wall glycoprotein biosynthetic process
ES966_18270	COG0697	spore germination
ES966_18290	COG2814	Major facilitator Superfamily
ES966_18295	COG1316	TRANSCRIPTIONal
ES966_18300	COG0561	phosphatase activity
ES966_18305	COG2433	Pfam Transposase IS66
ES966_18310	COG0791	NLP P60 protein
ES966_18320	COG2843	Capsule synthesis protein
ES966_18330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES966_18340	COG0697	spore germination
ES966_18345	COG0814	amino acid
ES966_18355	COG1609	Transcriptional regulator
ES966_18360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES966_18370	COG1129	ABC transporter
ES966_18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES966_18380	COG1879	ABC-type sugar transport system periplasmic component
ES966_18385	COG3103	Sh3 type 3 domain protein
ES966_18390	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES966_18395	COG3527	Alpha-acetolactate decarboxylase
ES966_18400	COG0028	Belongs to the TPP enzyme family
ES966_18405	COG0583	DNA-binding transcription factor activity
ES966_18410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES966_18425	COG5337	Spore coat protein CotH
ES966_18435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES966_18445	COG0405	Gamma-glutamyltransferase
ES966_18450	COG1522	sequence-specific DNA binding
ES966_18460	COG2059	Chromate
ES966_18470	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES966_18475	COG0583	DNA-binding transcription factor activity
ES966_18520	COG3878	Protein conserved in bacteria
ES966_18525	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES966_18530	COG4464	protein tyrosine phosphatase activity
ES966_18535	COG0489	protein tyrosine kinase activity
ES966_18540	COG3944	biosynthesis protein
ES966_18555	COG4715	Zinc finger, swim domain protein
ES966_18560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES966_18565	COG0561	phosphatase activity
ES966_18570	COG1349	DNA-binding transcription factor activity
ES966_18575	COG0629	single-stranded DNA binding
ES966_18600	COG0457	Tetratricopeptide repeat
ES966_18605	COG4786	Flagellar basal body rod
ES966_18610	COG4786	Flagellar basal body rod
ES966_18615	COG1077	Cell shape determining protein MreB Mrl
ES966_18620	COG1609	Transcriptional regulator
ES966_18625	COG1846	Transcriptional regulator
ES966_18630	COG2814	Major facilitator Superfamily
ES966_18635	COG1953	Uracil, thiamine, allantoin
ES966_18640	COG0477	Major facilitator Superfamily
ES966_18645	COG1335	isochorismatase
ES966_18650	COG0004	ammonium transporteR
ES966_18655	COG0347	Belongs to the P(II) protein family
ES966_18660	COG0772	Belongs to the SEDS family
ES966_18665	COG0671	phosphoesterase, PA-phosphatase related
ES966_18675	COG0739	heme binding
ES966_18680	COG1247	-acetyltransferase
ES966_18695	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES966_18705	COG0726	polysaccharide deacetylase
ES966_18715	COG1959	2 iron, 2 sulfur cluster binding
ES966_18730	COG0831	urea catabolic process
ES966_18740	COG1994	Peptidase M50
ES966_18745	COG0457	Tetratricopeptide repeat
ES966_18755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES966_18760	COG2304	oxidoreductase activity
ES966_18765	COG2304	oxidoreductase activity
ES966_18770	COG2385	sporulation resulting in formation of a cellular spore
ES966_18775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES966_18785	COG4836	Membrane
ES966_18825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES966_18855	COG0698	ribose 5-phosphate isomerase
ES966_18860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES966_18870	COG0009	L-threonylcarbamoyladenylate synthase
ES966_18875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES966_18895	COG2890	protein-(glutamine-N5) methyltransferase activity
ES966_18900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES966_18905	COG0346	lactoylglutathione lyase activity
ES966_18910	COG0789	Transcriptional regulator
ES966_18915	COG0679	Auxin Efflux Carrier
ES966_18920	COG0281	malic enzyme
ES966_18930	COG0254	rRNA binding
ES966_18935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES966_18940	COG1494	fructose-1,6-bisphosphatase
ES966_18945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES966_18955	COG0191	fructose-bisphosphate aldolase activity
ES966_18960	COG2204	response regulator
ES966_18965	COG4821	SIS domain
ES966_18980	COG0247	lactate metabolic process
ES966_18980	COG2181	nitrate reductase activity
ES966_18985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES966_19000	COG1132	(ABC) transporter
ES966_19005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES966_19015	COG2181	nitrate reductase activity
ES966_19020	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ES966_19025	COG1140	nitrate reductase beta subunit
ES966_19030	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ES966_19035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES966_19045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES966_19050	COG2223	nitrite transmembrane transporter activity
ES966_19060	COG4506	Protein conserved in bacteria
ES966_19065	COG0457	Tetratricopeptide repeat
ES966_19075	COG0010	Belongs to the arginase family
ES966_19080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES966_19100	COG1994	Peptidase M50
ES966_19105	COG1942	4-Oxalocrotonate Tautomerase
ES966_19110	COG1846	Transcriptional regulator
ES966_19120	COG0531	amino acid
ES966_19125	COG3465	dGTPase activity
ES966_19130	COG1078	dGTPase activity
ES966_19145	COG1695	Transcriptional regulator
ES966_19155	COG1131	(ABC) transporter
ES966_19160	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES966_19190	COG0583	DNA-binding transcription factor activity
ES966_19195	COG2855	membrane
ES966_19200	COG0280	phosphate acetyltransferase
ES966_19210	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_19215	COG0436	Aminotransferase
ES966_19245	COG2814	Major facilitator Superfamily
ES966_19250	COG2814	Major facilitator Superfamily
ES966_19255	COG0833	amino acid
ES966_19260	COG4187	Peptidase family M20/M25/M40
ES966_19265	COG1012	belongs to the aldehyde dehydrogenase family
ES966_19270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES966_19275	COG2205	protein histidine kinase activity
ES966_19280	COG0745	RESPONSE REGULATOR receiver
ES966_19295	COG1131	(ABC) transporter
ES966_19300	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES966_19305	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES966_19310	COG1088	dTDP-glucose 4,6-dehydratase activity
ES966_19315	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES966_19320	COG3980	spore coat polysaccharide biosynthesis protein
ES966_19330	COG2089	acid synthase
ES966_19335	COG0456	acetyltransferase
ES966_19340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES966_19345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES966_19350	COG0463	Glycosyl transferase, family 2
ES966_19360	COG2363	Small membrane protein
ES966_19365	COG2233	PERMEase
ES966_19380	COG1216	Glycosyl transferase, family 2
ES966_19395	COG1695	Transcriptional regulator
ES966_19400	COG0351	phosphomethylpyrimidine kinase
ES966_19410	COG1621	beta-fructofuranosidase activity
ES966_19415	COG1263	PTS System
ES966_19415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES966_19420	COG3711	transcriptional antiterminator
ES966_19430	COG1404	Belongs to the peptidase S8 family
ES966_19435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES966_19440	COG0778	Nitroreductase
ES966_19445	COG0772	Belongs to the SEDS family
ES966_19450	COG0454	-acetyltransferase
ES966_19470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES966_19475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES966_19480	COG2261	transglycosylase associated protein
ES966_19485	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES966_19490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES966_19495	COG2246	polysaccharide biosynthetic process
ES966_19500	COG1309	transcriptional regulator
ES966_19520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES966_19525	COG2837	iron assimilation
ES966_19530	COG2822	iron ion transport
ES966_19545	COG0583	DNA-binding transcription factor activity
ES966_19555	COG1346	cytolysis
ES966_19560	COG1131	(ABC) transporter
ES966_19590	COG4895	conserved protein (DUF2196)
ES966_19600	COG5504	Zn-dependent protease
ES966_19605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES966_19610	COG0346	lactoylglutathione lyase activity
ES966_19615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_19620	COG1404	Belongs to the peptidase S8 family
ES966_19625	COG1442	glycosyl transferase family 8
ES966_19630	COG2357	RelA SpoT domain protein
ES966_19635	COG1575	Belongs to the MenA family. Type 1 subfamily
ES966_19660	COG1696	Membrane protein involved in D-alanine export
ES966_19670	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES966_19675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES966_19680	COG1486	melibiose metabolic process
ES966_19685	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES966_19690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_19695	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_19700	COG3711	transcriptional antiterminator
ES966_19700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES966_19715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_19720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES966_19730	COG0640	Transcriptional regulator
ES966_19735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES966_19740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_19745	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES966_19750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES966_19755	COG2723	6-phospho-beta-galactosidase activity
ES966_19760	COG1940	carbohydrate kinase activity
ES966_19765	COG1482	cell wall glycoprotein biosynthetic process
ES966_19775	COG0753	catalase activity
ES966_19780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES966_19785	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES966_19790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES966_19795	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES966_19800	COG4988	ABC transporter
ES966_19805	COG1294	oxidase, subunit
ES966_19810	COG1271	oxidase subunit
ES966_19815	COG3493	citrate carrier protein
ES966_19820	COG0726	polysaccharide deacetylase
ES966_19825	COG3842	ATPase activity
ES966_19830	COG2508	Transcriptional regulator
ES966_19835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_19845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES966_19855	COG4894	glucomannan catabolic process
ES966_19860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES966_19865	COG0500	methyltransferase
ES966_19870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES966_19885	COG0693	protein deglycase activity
ES966_19885	COG0753	catalase activity
ES966_19890	COG2851	Citrate transporter
ES966_19895	COG2273	Hydrolase Family 16
ES966_19905	COG2270	Major facilitator Superfamily
ES966_19910	COG0513	Belongs to the DEAD box helicase family
ES966_20000	COG3209	COG3209 Rhs family protein
ES966_20010	COG0697	spore germination
ES966_20015	COG0589	response to stress
ES966_20025	COG0494	nUDIX hydrolase
ES966_20030	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
ES966_20060	COG0010	Belongs to the arginase family
ES966_20065	COG0833	amino acid
ES966_20075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES966_20085	COG2390	Transcriptional regulator
ES966_20115	COG1131	(ABC) transporter
ES966_20125	COG0561	phosphatase activity
ES966_20155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES966_20160	COG5294	Protein conserved in bacteria
ES966_20165	COG0577	efflux transmembrane transporter activity
ES966_20170	COG1136	(ABC) transporter
ES966_20175	COG2205	protein histidine kinase activity
ES966_20180	COG0745	RESPONSE REGULATOR receiver
ES966_20195	COG1082	Xylose isomerase domain protein TIM barrel
ES966_20205	COG2814	Major facilitator Superfamily
ES966_20235	COG1349	DNA-binding transcription factor activity
ES966_20240	COG0667	Aldo Keto reductase
ES966_20245	COG2814	Major facilitator Superfamily
ES966_20260	COG1028	Short-chain dehydrogenase reductase Sdr
ES966_20265	COG2197	response regulator
ES966_20270	COG4585	Histidine kinase
ES966_20275	COG3239	Fatty acid desaturase
ES966_20280	COG1309	transcriptional regulator
ES966_20285	COG1012	belongs to the aldehyde dehydrogenase family
ES966_20300	COG0640	Transcriptional regulator
ES966_20305	COG2814	Major facilitator Superfamily
ES966_20310	COG1714	RDD family
ES966_20320	COG0450	alkyl hydroperoxide reductase
ES966_20325	COG3634	alkyl hydroperoxide reductase activity
ES966_20330	COG3177	Filamentation induced by cAMP protein fic
ES966_20335	COG1113	amino acid transport
ES966_20345	COG2080	2 iron, 2 sulfur cluster binding
ES966_20360	COG2068	MobA-Related Protein
ES966_20385	COG1192	Involved in chromosome partitioning
ES966_20420	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES966_20425	COG0667	Aldo Keto reductase
ES966_20430	COG0456	acetyltransferase
ES966_20435	COG0457	Tetratricopeptide repeat
ES966_20440	COG0010	Belongs to the arginase family
ES966_20445	COG0833	amino acid
ES966_20450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES966_20455	COG5658	integral membrane protein
ES966_20460	COG0640	Transcriptional regulator
ES966_20465	COG3829	transcription factor binding
ES966_20475	COG0488	(ABC) transporter
ES966_20495	COG3850	Histidine kinase
ES966_20495	COG5002	protein histidine kinase activity
ES966_20510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES966_20515	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES966_20520	COG4853	Protein conserved in bacteria
ES966_20525	COG4863	YycH protein
ES966_20530	COG5002	protein histidine kinase activity
ES966_20535	COG0745	RESPONSE REGULATOR receiver
ES966_20570	COG0346	lactoylglutathione lyase activity
ES966_20575	COG0305	Participates in initiation and elongation during chromosome replication
ES966_20590	COG3093	addiction module antidote protein HigA
ES966_20600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES966_20605	COG0297	glycogen (starch) synthase activity
ES966_20615	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES966_20620	COG0438	transferase activity, transferring glycosyl groups
ES966_20630	COG2112	serine threonine protein kinase
ES966_20640	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES966_20645	COG4241	membrane
ES966_20655	COG5577	PFAM Coat F domain
ES966_20660	COG1733	regulation of RNA biosynthetic process
ES966_20675	COG1621	beta-fructofuranosidase activity
ES966_20680	COG1621	beta-fructofuranosidase activity
ES966_20690	COG2318	DinB family
ES966_20695	COG2211	Major facilitator Superfamily
ES966_20710	COG0778	Nitroreductase
ES966_20715	COG1846	Transcriptional regulator
ES966_20720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES966_20725	COG1846	Transcriptional regulator
ES966_20730	COG2153	protein acetylation
ES966_20740	COG0546	phosphoglycolate phosphatase activity
ES966_20820	COG1131	(ABC) transporter
ES966_20835	COG1331	Highly conserved protein containing a thioredoxin domain
ES966_20840	COG1266	CAAX protease self-immunity
ES966_20845	COG0477	Major facilitator Superfamily
ES966_20845	COG2814	Major facilitator Superfamily
ES966_20850	COG0346	lactoylglutathione lyase activity
ES966_20855	COG1609	Transcriptional regulator
ES966_20865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES966_20870	COG2169	Transcriptional regulator
ES966_20880	COG0629	single-stranded DNA binding
ES966_20890	COG0012	GTP binding
ES966_20895	COG0243	molybdopterin cofactor binding
ES966_20900	COG4481	Protein conserved in bacteria
ES966_20905	COG3949	Membrane
ES966_20920	COG1475	DNA binding
ES966_20925	COG1192	Involved in chromosome partitioning
ES966_20950	COG1847	R3H domain protein
ES966_20955	COG0706	membrane insertase activity
ES966_20965	COG0230	Belongs to the bacterial ribosomal protein bL34 family