locus-tag	class	description
FE838_00010	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FE838_00015	COG3177	Filamentation induced by cAMP protein fic
FE838_00125	COG0739	heme binding
FE838_00125	COG0741	lytic transglycosylase activity
FE838_00125	COG1196	nuclear chromosome segregation
FE838_00205	COG1192	Involved in chromosome partitioning
FE838_00215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FE838_00220	COG0778	Nitroreductase
FE838_00230	COG1640	4-alpha-glucanotransferase
FE838_00245	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FE838_00265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FE838_00270	COG0318	PFAM AMP-dependent synthetase and ligase
FE838_00305	COG0359	binds to the 23S rRNA
FE838_00310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FE838_00315	COG0360	Binds together with S18 to 16S ribosomal RNA
FE838_00335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FE838_00340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FE838_00370	COG1131	(ABC) transporter
FE838_00385	COG2431	L-lysine efflux transmembrane transporter activity
FE838_00395	COG1193	negative regulation of DNA recombination
FE838_00430	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FE838_00445	COG2234	aminopeptidase activity
FE838_00470	COG0702	epimerase
FE838_00475	COG1629	transport
FE838_00490	COG3537	Alpha-1,2-mannosidase
FE838_00505	COG1629	transport
FE838_00505	COG4206	TonB-dependent receptor
FE838_00525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FE838_00530	COG0802	atpase or kinase
FE838_00555	COG0714	Associated with various cellular activities
FE838_00605	COG3385	transposase activity
FE838_00640	COG3118	belongs to the thioredoxin family
FE838_00650	COG0688	phosphatidylethanolamine metabolic process
FE838_00655	COG1183	phosphatidylcholine synthase activity
FE838_00675	COG0792	nuclease activity
FE838_00700	COG0534	Mate efflux family protein
FE838_00705	COG0528	UMP kinase activity
FE838_00740	COG0233	cytoplasmic translational termination
FE838_00745	COG1162	GTPase activity
FE838_00755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE838_00775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
FE838_00775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
FE838_00785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FE838_00795	COG1629	transport
FE838_00795	COG4206	TonB-dependent receptor
FE838_00815	COG1629	transport
FE838_00830	COG4974	Belongs to the 'phage' integrase family
FE838_00835	COG4771	TonB-dependent receptor
FE838_00845	COG2095	MarC family integral membrane protein
FE838_00860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FE838_00870	COG1435	thymidine kinase activity
FE838_00875	COG0628	permease
FE838_00885	COG4974	Belongs to the 'phage' integrase family
FE838_00990	COG3344	reverse transcriptase
FE838_01060	COG1475	DNA binding
FE838_01065	COG3969	phosphoadenosine phosphosulfate
FE838_01130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FE838_01130	COG0551	DNA topoisomerase type I activity
FE838_01270	COG2433	Pfam Transposase IS66
FE838_01285	COG2433	Pfam Transposase IS66
FE838_01325	COG1396	sequence-specific DNA binding
FE838_01335	COG4771	TonB-dependent receptor
FE838_01345	COG4771	TonB-dependent receptor
FE838_01380	COG0693	protein deglycase activity
FE838_01435	COG0300	oxidoreductase activity
FE838_01445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FE838_01450	COG1595	DNA-templated transcription, initiation
FE838_01455	COG0110	maltose O-acetyltransferase activity
FE838_01465	COG1522	sequence-specific DNA binding
FE838_01490	COG2205	protein histidine kinase activity
FE838_01490	COG3292	Two component regulator propeller
FE838_01490	COG0745	RESPONSE REGULATOR receiver
FE838_01500	COG1629	transport
FE838_01540	COG2818	Glycosylase
FE838_01545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FE838_01550	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
FE838_01555	COG0460	homoserine dehydrogenase
FE838_01555	COG0527	aspartate kinase activity
FE838_01565	COG0252	asparaginase activity
FE838_01575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FE838_01580	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FE838_01590	COG4771	TonB-dependent receptor
FE838_01610	COG0826	peptidase U32
FE838_01615	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FE838_01625	COG0436	Aminotransferase
FE838_01630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FE838_01650	COG0519	Catalyzes the synthesis of GMP from XMP
FE838_01655	COG5002	protein histidine kinase activity
FE838_01660	COG2205	protein histidine kinase activity
FE838_01670	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FE838_01680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FE838_01750	COG3250	beta-galactosidase activity
FE838_01755	COG2204	response regulator
FE838_01760	COG0446	pyridine nucleotide-disulphide oxidoreductase
FE838_01785	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_01790	COG0737	Belongs to the 5'-nucleotidase family
FE838_01795	COG0737	Belongs to the 5'-nucleotidase family
FE838_01825	COG4974	Belongs to the 'phage' integrase family
FE838_01890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FE838_01895	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_01905	COG4771	TonB-dependent receptor
FE838_01980	COG1333	cytochrome c biogenesis protein
FE838_01980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FE838_02075	COG0335	large ribosomal subunit rRNA binding
FE838_02095	COG1940	carbohydrate kinase activity
FE838_02100	COG0577	efflux transmembrane transporter activity
FE838_02100	COG1136	(ABC) transporter
FE838_02105	COG0577	efflux transmembrane transporter activity
FE838_02105	COG1136	(ABC) transporter
FE838_02110	COG1136	(ABC) transporter
FE838_02110	COG0577	efflux transmembrane transporter activity
FE838_02115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_02125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FE838_02125	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FE838_02135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FE838_02155	COG2996	Protein conserved in bacteria
FE838_02180	COG0039	L-malate dehydrogenase activity
FE838_02190	COG2217	Heavy metal translocating P-type atpase
FE838_02220	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FE838_02225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FE838_02230	COG0509	glycine decarboxylation via glycine cleavage system
FE838_02245	COG0006	proline dipeptidase activity
FE838_02250	COG3250	beta-galactosidase activity
FE838_02255	COG3408	Glycogen debranching enzyme
FE838_02260	COG3458	cephalosporin-C deacetylase activity
FE838_02275	COG1283	sodium-dependent phosphate transmembrane transporter activity
FE838_02290	COG4206	TonB-dependent receptor
FE838_02290	COG1629	transport
FE838_02330	COG1773	rubredoxin
FE838_02340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FE838_02345	COG1011	Hydrolase
FE838_02350	COG0196	riboflavin kinase activity
FE838_02360	COG1266	CAAX protease self-immunity
FE838_02370	COG3655	Transcriptional regulator
FE838_02375	COG2166	iron-sulfur cluster assembly
FE838_02380	COG2234	aminopeptidase activity
FE838_02385	COG1619	proteins homologs of microcin C7 resistance protein MccF
FE838_02395	COG0280	phosphate acetyltransferase
FE838_02400	COG3426	butyrate kinase activity
FE838_02440	COG1629	transport
FE838_02440	COG4206	TonB-dependent receptor
FE838_02455	COG1185	polyribonucleotide nucleotidyltransferase activity
FE838_02465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FE838_02485	COG1595	DNA-templated transcription, initiation
FE838_02495	COG0076	glutamate decarboxylase activity
FE838_02500	COG2066	Belongs to the glutaminase family
FE838_02510	COG0531	amino acid
FE838_02690	COG4804	nuclease activity
FE838_02735	COG3344	reverse transcriptase
FE838_02745	COG3344	reverse transcriptase
FE838_02755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FE838_02755	COG2205	protein histidine kinase activity
FE838_02755	COG2198	Histidine kinase
FE838_02755	COG0784	Response regulator, receiver
FE838_02760	COG4948	Mandelate Racemase Muconate Lactonizing
FE838_02765	COG0657	acetylesterase activity
FE838_02765	COG2755	lipolytic protein G-D-S-L family
FE838_02770	COG3661	Belongs to the glycosyl hydrolase 67 family
FE838_02785	COG0702	epimerase
FE838_02790	COG4771	TonB-dependent receptor
FE838_02800	COG0745	RESPONSE REGULATOR receiver
FE838_02800	COG3292	Two component regulator propeller
FE838_02800	COG2205	protein histidine kinase activity
FE838_02810	COG3537	Alpha-1,2-mannosidase
FE838_02840	COG4974	Belongs to the 'phage' integrase family
FE838_02885	COG0551	DNA topoisomerase type I activity
FE838_02885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FE838_03105	COG0667	Aldo Keto reductase
FE838_03110	COG3250	beta-galactosidase activity
FE838_03145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_03155	COG1309	transcriptional regulator
FE838_03160	COG2986	histidine ammonia-lyase
FE838_03170	COG1228	amidohydrolase
FE838_03180	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FE838_03195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FE838_03210	COG0203	ribosomal protein L17
FE838_03215	COG0202	RNA polymerase activity
FE838_03220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FE838_03225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FE838_03230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FE838_03235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FE838_03240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FE838_03255	COG0200	Binds to the 23S rRNA
FE838_03260	COG1841	ribosomal large subunit assembly
FE838_03265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FE838_03270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FE838_03275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FE838_03280	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FE838_03285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FE838_03290	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FE838_03295	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FE838_03300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FE838_03305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FE838_03310	COG0255	Belongs to the universal ribosomal protein uL29 family
FE838_03315	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FE838_03320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FE838_03325	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FE838_03330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FE838_03335	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FE838_03340	COG0089	rRNA binding
FE838_03345	COG0088	Forms part of the polypeptide exit tunnel
FE838_03350	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FE838_03355	COG0051	transcription antitermination factor activity, RNA binding
FE838_03360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FE838_03365	COG0049	tRNA binding
FE838_03370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FE838_03380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FE838_03385	COG0085	RNA polymerase activity
FE838_03390	COG0222	ribosome binding
FE838_03395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FE838_03400	COG0081	regulation of translation
FE838_03405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FE838_03415	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FE838_03425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FE838_03455	COG4974	Belongs to the 'phage' integrase family
FE838_03460	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FE838_03470	COG0006	proline dipeptidase activity
FE838_03475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FE838_03495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FE838_03505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FE838_03515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FE838_03530	COG1027	Aspartate ammonia-lyase
FE838_03535	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FE838_03540	COG0252	asparaginase activity
FE838_03555	COG2096	Adenosyltransferase
FE838_03570	COG3328	transposase activity
FE838_03600	COG0515	serine threonine protein kinase
FE838_03600	COG2815	serine threonine protein kinase
FE838_03615	COG0631	protein serine/threonine phosphatase activity
FE838_03625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE838_03665	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
FE838_03665	COG0662	Cupin 2, conserved barrel domain protein
FE838_03670	COG0318	PFAM AMP-dependent synthetase and ligase
FE838_03675	COG1396	sequence-specific DNA binding
FE838_03690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FE838_03705	COG2059	Chromate
FE838_03710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FE838_03715	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FE838_03745	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FE838_03755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FE838_03775	COG0483	inositol monophosphate 1-phosphatase activity
FE838_03785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FE838_03790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FE838_03795	COG4206	TonB-dependent receptor
FE838_03795	COG1629	transport
FE838_03825	COG3634	alkyl hydroperoxide reductase activity
FE838_03835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FE838_03840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FE838_03860	COG1629	transport
FE838_03860	COG4206	TonB-dependent receptor
FE838_03900	COG0745	RESPONSE REGULATOR receiver
FE838_03900	COG0745	RESPONSE REGULATOR receiver
FE838_03900	COG2205	protein histidine kinase activity
FE838_03900	COG2205	protein histidine kinase activity
FE838_03900	COG3292	Two component regulator propeller
FE838_03900	COG3292	Two component regulator propeller
FE838_03915	COG0018	arginyl-trna synthetase
FE838_03925	COG0705	Rhomboid family
FE838_03940	COG0339	signal peptide processing
FE838_03945	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FE838_03955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FE838_03955	COG0674	pyruvate-flavodoxin oxidoreductase activity
FE838_03960	COG1013	pyruvate-flavodoxin oxidoreductase activity
FE838_03965	COG4591	ABC-type transport system involved in lipoprotein release permease component
FE838_03970	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FE838_03990	COG4974	Belongs to the 'phage' integrase family
FE838_04005	COG0606	chelatase, subunit chli
FE838_04025	COG2205	protein histidine kinase activity
FE838_04045	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_04050	COG3250	beta-galactosidase activity
FE838_04065	COG0561	phosphatase activity
FE838_04070	COG4206	TonB-dependent receptor
FE838_04070	COG1629	transport
FE838_04075	COG2205	protein histidine kinase activity
FE838_04075	COG0745	RESPONSE REGULATOR receiver
FE838_04075	COG0745	RESPONSE REGULATOR receiver
FE838_04075	COG2205	protein histidine kinase activity
FE838_04075	COG3292	Two component regulator propeller
FE838_04075	COG3292	Two component regulator propeller
FE838_04095	COG0438	transferase activity, transferring glycosyl groups
FE838_04100	COG0438	transferase activity, transferring glycosyl groups
FE838_04115	COG1215	transferase activity, transferring glycosyl groups
FE838_04120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FE838_04140	COG1442	glycosyl transferase family 8
FE838_04155	COG1216	Glycosyl transferase, family 2
FE838_04155	COG1442	glycosyl transferase family 8
FE838_04190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FE838_04210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE838_04215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FE838_04245	COG4771	TonB-dependent receptor
FE838_04260	COG0745	RESPONSE REGULATOR receiver
FE838_04260	COG3292	Two component regulator propeller
FE838_04260	COG2205	protein histidine kinase activity
FE838_04300	COG1629	transport
FE838_04335	COG3940	Belongs to the glycosyl hydrolase 43 family
FE838_04340	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FE838_04345	COG3119	arylsulfatase activity
FE838_04370	COG0702	epimerase
FE838_04375	COG4206	TonB-dependent receptor
FE838_04375	COG1629	transport
FE838_04385	COG3250	beta-galactosidase activity
FE838_04390	COG3292	Two component regulator propeller
FE838_04390	COG0745	RESPONSE REGULATOR receiver
FE838_04390	COG2205	protein histidine kinase activity
FE838_04445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE838_04445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE838_04460	COG0438	transferase activity, transferring glycosyl groups
FE838_04470	COG0438	transferase activity, transferring glycosyl groups
FE838_04505	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FE838_04510	COG0438	transferase activity, transferring glycosyl groups
FE838_04515	COG1216	Glycosyl transferase, family 2
FE838_04520	COG2133	pyrroloquinoline quinone binding
FE838_04520	COG5183	chlorophyll binding
FE838_04540	COG4206	TonB-dependent receptor
FE838_04540	COG1629	transport
FE838_04555	COG1882	Formate acetyltransferase
FE838_04600	COG5492	domain, Protein
FE838_04615	COG0702	epimerase
FE838_04620	COG4771	TonB-dependent receptor
FE838_04625	COG3250	beta-galactosidase activity
FE838_04635	COG3292	Two component regulator propeller
FE838_04635	COG0745	RESPONSE REGULATOR receiver
FE838_04635	COG3292	Two component regulator propeller
FE838_04635	COG2205	protein histidine kinase activity
FE838_04635	COG0745	RESPONSE REGULATOR receiver
FE838_04635	COG2205	protein histidine kinase activity
FE838_04655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FE838_04660	COG0545	Peptidyl-prolyl cis-trans isomerase
FE838_04665	COG0545	Peptidyl-prolyl cis-trans isomerase
FE838_04710	COG2003	Belongs to the UPF0758 family
FE838_04795	COG0210	DNA helicase
FE838_04850	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_04865	COG1629	transport
FE838_04870	COG0561	phosphatase activity
FE838_04925	COG4771	TonB-dependent receptor
FE838_04945	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FE838_04950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FE838_04975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FE838_04980	COG3409	Peptidoglycan-binding domain 1 protein
FE838_04980	COG0793	Belongs to the peptidase S41A family
FE838_05035	COG1629	transport
FE838_05050	COG3292	Two component regulator propeller
FE838_05050	COG2205	protein histidine kinase activity
FE838_05050	COG0745	RESPONSE REGULATOR receiver
FE838_05060	COG3119	arylsulfatase activity
FE838_05075	COG1053	succinate dehydrogenase
FE838_05080	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FE838_05090	COG3119	arylsulfatase activity
FE838_05135	COG3345	alpha-galactosidase
FE838_05160	COG0758	DNA mediated transformation
FE838_05160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FE838_05170	COG0826	peptidase U32
FE838_05175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FE838_05200	COG0557	exoribonuclease II activity
FE838_05215	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FE838_05220	COG1917	Cupin 2, conserved barrel domain protein
FE838_05225	COG1621	beta-fructofuranosidase activity
FE838_05245	COG1501	Belongs to the glycosyl hydrolase 31 family
FE838_05265	COG0702	epimerase
FE838_05270	COG4771	TonB-dependent receptor
FE838_05295	COG3408	Glycogen debranching enzyme
FE838_05295	COG3119	arylsulfatase activity
FE838_05305	COG2205	protein histidine kinase activity
FE838_05305	COG3292	Two component regulator propeller
FE838_05305	COG0745	RESPONSE REGULATOR receiver
FE838_05325	COG3119	arylsulfatase activity
FE838_05335	COG4771	TonB-dependent receptor
FE838_05365	COG3119	arylsulfatase activity
FE838_05380	COG1073	alpha beta
FE838_05385	COG2814	Major facilitator Superfamily
FE838_05395	COG1012	belongs to the aldehyde dehydrogenase family
FE838_05405	COG0012	GTP binding
FE838_05410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FE838_05415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FE838_05430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FE838_05435	COG0662	Cupin 2, conserved barrel domain protein
FE838_05435	COG2207	Transcriptional regulator
FE838_05440	COG0697	spore germination
FE838_05455	COG0495	leucyl-tRNA aminoacylation
FE838_05460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FE838_05465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FE838_05470	COG1360	Flagellar Motor Protein
FE838_05475	COG3537	Alpha-1,2-mannosidase
FE838_05495	COG0745	RESPONSE REGULATOR receiver
FE838_05495	COG3292	Two component regulator propeller
FE838_05495	COG2205	protein histidine kinase activity
FE838_05505	COG4974	Belongs to the 'phage' integrase family
FE838_05610	COG1629	transport
FE838_05630	COG5434	Belongs to the glycosyl hydrolase 28 family
FE838_05640	COG0584	glycerophosphoryl diester phosphodiesterase
FE838_05645	COG4948	Mandelate Racemase Muconate Lactonizing
FE838_05650	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FE838_05670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FE838_05670	COG0731	radical SAM domain protein
FE838_05690	COG2205	protein histidine kinase activity
FE838_05690	COG0745	RESPONSE REGULATOR receiver
FE838_05690	COG3292	Two component regulator propeller
FE838_05690	COG3292	Two component regulator propeller
FE838_05690	COG0745	RESPONSE REGULATOR receiver
FE838_05690	COG2205	protein histidine kinase activity
FE838_05700	COG4206	TonB-dependent receptor
FE838_05700	COG1629	transport
FE838_05715	COG3119	arylsulfatase activity
FE838_05720	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_05725	COG3250	beta-galactosidase activity
FE838_05735	COG0659	secondary active sulfate transmembrane transporter activity
FE838_05740	COG1592	Rubrerythrin
FE838_05765	COG2027	D-alanyl-D-alanine carboxypeptidase
FE838_05795	COG0427	acetyl-CoA hydrolase
FE838_05805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FE838_05830	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_05880	COG2177	Part of the ABC transporter FtsEX involved in
FE838_05890	COG1968	undecaprenyl-diphosphatase activity
FE838_05895	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FE838_05900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FE838_05910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FE838_05925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FE838_05950	COG1611	Belongs to the LOG family
FE838_05965	COG0594	ribonuclease P activity
FE838_05970	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FE838_05980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FE838_05990	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FE838_05995	COG1028	Short-chain dehydrogenase reductase Sdr
FE838_06035	COG1629	transport
FE838_06035	COG4206	TonB-dependent receptor
FE838_06060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FE838_06075	COG1121	(ABC) transporter
FE838_06085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FE838_06085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FE838_06105	COG1506	peptidase
FE838_06105	COG0823	Involved in the tonB-independent uptake of proteins
FE838_06110	COG0116	Belongs to the methyltransferase superfamily
FE838_06110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FE838_06115	COG1045	serine acetyltransferase
FE838_06120	COG3275	phosphorelay sensor kinase activity
FE838_06125	COG3279	Response regulator of the LytR AlgR family
FE838_06140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE838_06140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FE838_06145	COG0142	geranyltranstransferase activity
FE838_06165	COG1694	Mazg nucleotide pyrophosphohydrolase
FE838_06170	COG1490	D-aminoacyl-tRNA deacylase activity
FE838_06175	COG0322	excinuclease ABC activity
FE838_06180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FE838_06185	COG0445	tRNA wobble uridine modification
FE838_06200	COG4771	TonB-dependent receptor
FE838_06230	COG2197	response regulator
FE838_06240	COG1629	transport
FE838_06240	COG4206	TonB-dependent receptor
FE838_06260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FE838_06265	COG0700	Nucleoside recognition
FE838_06270	COG2255	four-way junction helicase activity
FE838_06290	COG3591	Belongs to the peptidase S1B family
FE838_06305	COG3250	beta-galactosidase activity
FE838_06310	COG3250	beta-galactosidase activity
FE838_06315	COG4948	Mandelate Racemase Muconate Lactonizing
FE838_06325	COG0702	epimerase
FE838_06330	COG4771	TonB-dependent receptor
FE838_06355	COG2205	protein histidine kinase activity
FE838_06355	COG3292	Two component regulator propeller
FE838_06355	COG0745	RESPONSE REGULATOR receiver
FE838_06360	COG0513	Belongs to the DEAD box helicase family
FE838_06385	COG0612	Peptidase, M16
FE838_06395	COG4771	TonB-dependent receptor
FE838_06400	COG0702	epimerase
FE838_06415	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_06435	COG0681	Belongs to the peptidase S26 family
FE838_06445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FE838_06455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE838_06465	COG5492	domain, Protein
FE838_06475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FE838_06500	COG0702	epimerase
FE838_06505	COG4771	TonB-dependent receptor
FE838_06510	COG3119	arylsulfatase activity
FE838_06515	COG0745	RESPONSE REGULATOR receiver
FE838_06515	COG3292	Two component regulator propeller
FE838_06515	COG0745	RESPONSE REGULATOR receiver
FE838_06515	COG2205	protein histidine kinase activity
FE838_06515	COG3292	Two component regulator propeller
FE838_06515	COG2205	protein histidine kinase activity
FE838_06525	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE838_06530	COG1538	Outer membrane efflux protein
FE838_06540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_06545	COG3250	beta-galactosidase activity
FE838_06570	COG0702	epimerase
FE838_06575	COG4771	TonB-dependent receptor
FE838_06585	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FE838_06590	COG3119	arylsulfatase activity
FE838_06595	COG5492	domain, Protein
FE838_06600	COG0215	cysteine-tRNA ligase activity
FE838_06605	COG0561	phosphatase activity
FE838_06610	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FE838_06615	COG0482	sulfurtransferase activity
FE838_06625	COG0205	6-phosphofructokinase activity
FE838_06630	COG0571	ribonuclease III activity
FE838_06635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FE838_06640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FE838_06650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FE838_06680	COG1216	Glycosyl transferase, family 2
FE838_06680	COG1442	glycosyl transferase family 8
FE838_06700	COG1216	Glycosyl transferase, family 2
FE838_06700	COG1442	glycosyl transferase family 8
FE838_06705	COG1216	Glycosyl transferase, family 2
FE838_06720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FE838_06725	COG0436	Aminotransferase
FE838_06745	COG0463	Glycosyl transferase, family 2
FE838_06775	COG1132	(ABC) transporter
FE838_06800	COG3341	Caulimovirus viroplasmin
FE838_06800	COG0328	RNA-DNA hybrid ribonuclease activity
FE838_06810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FE838_06815	COG1166	arginine decarboxylase activity
FE838_06820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FE838_06825	COG1595	DNA-templated transcription, initiation
FE838_06855	COG0779	Required for maturation of 30S ribosomal subunits
FE838_06860	COG0195	Participates in both transcription termination and antitermination
FE838_06865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FE838_06875	COG0719	Fe-S assembly protein
FE838_06880	COG0396	ATPase activity
FE838_06885	COG0719	Fe-S assembly protein
FE838_06890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FE838_06895	COG0393	Putative heavy-metal-binding
FE838_06905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FE838_06910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FE838_06930	COG5433	transposase activity
FE838_06945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FE838_06995	COG0187	DNA topoisomerase II activity
FE838_07000	COG0268	Binds directly to 16S ribosomal RNA
FE838_07015	COG1381	Involved in DNA repair and RecF pathway recombination
FE838_07075	COG1610	YqeY-like protein
FE838_07080	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FE838_07095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FE838_07100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FE838_07105	COG0772	Belongs to the SEDS family
FE838_07110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FE838_07115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FE838_07120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FE838_07135	COG0275	rRNA processing
FE838_07140	COG2001	Belongs to the MraZ family
FE838_07145	COG1595	DNA-templated transcription, initiation
FE838_07160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FE838_07165	COG0756	dUTP diphosphatase activity
FE838_07180	COG4942	peptidase
FE838_07185	COG3292	Two component regulator propeller
FE838_07185	COG2205	protein histidine kinase activity
FE838_07185	COG0745	RESPONSE REGULATOR receiver
FE838_07215	COG0673	inositol 2-dehydrogenase activity
FE838_07225	COG0673	inositol 2-dehydrogenase activity
FE838_07235	COG0702	epimerase
FE838_07240	COG4771	TonB-dependent receptor
FE838_07290	COG0702	epimerase
FE838_07295	COG4771	TonB-dependent receptor
FE838_07330	COG1629	transport
FE838_07345	COG3119	arylsulfatase activity
FE838_07380	COG4771	TonB-dependent receptor
FE838_07385	COG0702	epimerase
FE838_07420	COG3250	beta-galactosidase activity
FE838_07435	COG3507	Belongs to the glycosyl hydrolase 43 family
FE838_07450	COG1629	transport
FE838_07455	COG0561	phosphatase activity
FE838_07490	COG3537	Alpha-1,2-mannosidase
FE838_07505	COG3537	Alpha-1,2-mannosidase
FE838_07515	COG2017	converts alpha-aldose to the beta-anomer
FE838_07600	COG1373	ATPase (AAA superfamily
FE838_07605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FE838_07610	COG1022	Amp-dependent synthetase and ligase
FE838_07615	COG0612	Peptidase, M16
FE838_07620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FE838_07630	COG2954	triphosphatase activity
FE838_07695	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_07705	COG4771	TonB-dependent receptor
FE838_07765	COG0673	inositol 2-dehydrogenase activity
FE838_07775	COG0673	inositol 2-dehydrogenase activity
FE838_07795	COG0363	glucosamine-6-phosphate deaminase activity
FE838_07800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FE838_07820	COG3345	alpha-galactosidase
FE838_07850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_07865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FE838_07865	COG0517	IMP dehydrogenase activity
FE838_07880	COG4771	TonB-dependent receptor
FE838_07890	COG2814	Major facilitator Superfamily
FE838_07900	COG3458	cephalosporin-C deacetylase activity
FE838_07905	COG1609	Transcriptional regulator
FE838_07905	COG2207	Transcriptional regulator
FE838_07915	COG0423	glycine-tRNA ligase activity
FE838_07925	COG1609	Transcriptional regulator
FE838_07940	COG0738	Major facilitator superfamily
FE838_07945	COG1063	alcohol dehydrogenase
FE838_07960	COG2211	Major facilitator Superfamily
FE838_07965	COG2385	sporulation resulting in formation of a cellular spore
FE838_07965	COG2247	cell wall binding repeat
FE838_07970	COG1215	transferase activity, transferring glycosyl groups
FE838_07975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FE838_08045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FE838_08055	COG0475	glutathione-regulated potassium exporter activity
FE838_08055	COG0589	response to stress
FE838_08060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FE838_08065	COG1136	(ABC) transporter
FE838_08075	COG0733	neurotransmitter:sodium symporter activity
FE838_08085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FE838_08090	COG0784	Response regulator, receiver
FE838_08090	COG5002	protein histidine kinase activity
FE838_08095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FE838_08100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FE838_08105	COG0312	modulator of DNA gyrase
FE838_08110	COG0312	modulator of DNA gyrase
FE838_08115	COG1704	LemA family
FE838_08145	COG3507	Belongs to the glycosyl hydrolase 43 family
FE838_08160	COG1501	Belongs to the glycosyl hydrolase 31 family
FE838_08170	COG4948	Mandelate Racemase Muconate Lactonizing
FE838_08180	COG3507	Belongs to the glycosyl hydrolase 43 family
FE838_08185	COG1082	Xylose isomerase domain protein TIM barrel
FE838_08215	COG1629	transport
FE838_08215	COG4206	TonB-dependent receptor
FE838_08255	COG0745	RESPONSE REGULATOR receiver
FE838_08255	COG3292	Two component regulator propeller
FE838_08255	COG2205	protein histidine kinase activity
FE838_08265	COG1629	transport
FE838_08315	COG1346	cytolysis
FE838_08320	COG1380	Effector of murein hydrolase LrgA
FE838_08325	COG0280	phosphate acetyltransferase
FE838_08330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FE838_08335	COG0463	Glycosyl transferase, family 2
FE838_08335	COG1216	Glycosyl transferase, family 2
FE838_08340	COG2003	Belongs to the UPF0758 family
FE838_08350	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE838_08355	COG0366	Alpha amylase catalytic
FE838_08370	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FE838_08375	COG1629	transport
FE838_08375	COG4206	TonB-dependent receptor
FE838_08380	COG1082	Xylose isomerase domain protein TIM barrel
FE838_08385	COG0366	Alpha amylase catalytic
FE838_08405	COG1785	Belongs to the alkaline phosphatase family
FE838_08410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FE838_08415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FE838_08420	COG2815	serine threonine protein kinase
FE838_08420	COG0515	serine threonine protein kinase
FE838_08425	COG0564	pseudouridine synthase activity
FE838_08430	COG1181	Belongs to the D-alanine--D-alanine ligase family
FE838_08450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FE838_08455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FE838_08460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FE838_08465	COG0436	Aminotransferase
FE838_08475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FE838_08490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FE838_08495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FE838_08505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FE838_08505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FE838_08510	COG2890	protein-(glutamine-N5) methyltransferase activity
FE838_08520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FE838_08530	COG0165	Argininosuccinate lyase
FE838_08545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FE838_08570	COG3292	Two component regulator propeller
FE838_08570	COG0745	RESPONSE REGULATOR receiver
FE838_08570	COG3292	Two component regulator propeller
FE838_08570	COG2205	protein histidine kinase activity
FE838_08570	COG0745	RESPONSE REGULATOR receiver
FE838_08570	COG2205	protein histidine kinase activity
FE838_08575	COG0471	metal ion transport
FE838_08630	COG4771	TonB-dependent receptor
FE838_08650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FE838_08655	COG1396	sequence-specific DNA binding
FE838_08655	COG1917	Cupin 2, conserved barrel domain protein
FE838_08660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FE838_08665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FE838_08670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FE838_08675	COG0137	argininosuccinate synthase activity
FE838_08685	COG1438	arginine binding
FE838_08690	COG1070	Carbohydrate kinase
FE838_08695	COG4806	L-rhamnose isomerase
FE838_08705	COG0235	Class ii aldolase
FE838_08710	COG1454	alcohol dehydrogenase
FE838_08740	COG0564	pseudouridine synthase activity
FE838_08800	COG3537	Alpha-1,2-mannosidase
FE838_08810	COG0745	RESPONSE REGULATOR receiver
FE838_08810	COG2205	protein histidine kinase activity
FE838_08810	COG3292	Two component regulator propeller
FE838_08820	COG1629	transport
FE838_08820	COG4206	TonB-dependent receptor
FE838_08825	COG0702	epimerase
FE838_08860	COG3119	arylsulfatase activity
FE838_08875	COG3119	arylsulfatase activity
FE838_08880	COG0745	RESPONSE REGULATOR receiver
FE838_08880	COG3292	Two component regulator propeller
FE838_08880	COG2205	protein histidine kinase activity
FE838_08885	COG2204	response regulator
FE838_08890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FE838_08895	COG0612	Peptidase, M16
FE838_08900	COG0534	Mate efflux family protein
FE838_08905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FE838_08905	COG2205	protein histidine kinase activity
FE838_08925	COG0488	(ABC) transporter
FE838_08930	COG3590	peptidase
FE838_08935	COG0138	bifunctional purine biosynthesis protein purh
FE838_08960	COG0772	Belongs to the SEDS family
FE838_08970	COG1774	PSP1 C-terminal conserved region
FE838_08975	COG0470	DNA polymerase III
FE838_08980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FE838_08990	COG2193	ferroxidase activity
FE838_09075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FE838_09080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FE838_09085	COG1160	GTP binding
FE838_09095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FE838_09100	COG1127	ABC transporter
FE838_09105	COG0724	RNA recognition motif
FE838_09110	COG0544	peptidyl-prolyl cis-trans isomerase activity
FE838_09115	COG0740	serine-type endopeptidase activity
FE838_09120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FE838_09125	COG0514	ATP-dependent DNA helicase (RecQ)
FE838_09130	COG0517	IMP dehydrogenase activity
FE838_09130	COG0516	GMP reductase activity
FE838_09135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE838_09145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FE838_09160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FE838_09175	COG4771	TonB-dependent receptor
FE838_09195	COG3537	Alpha-1,2-mannosidase
FE838_09240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FE838_09255	COG3022	response to hydroperoxide
FE838_09260	COG0110	maltose O-acetyltransferase activity
FE838_09280	COG1187	pseudouridine synthase activity
FE838_09285	COG0017	Asparaginyl-tRNA synthetase
FE838_09295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FE838_09300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FE838_09305	COG0052	Belongs to the universal ribosomal protein uS2 family
FE838_09310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FE838_09330	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FE838_09335	COG0179	Fumarylacetoacetate (FAA) hydrolase
FE838_09340	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FE838_09360	COG0482	sulfurtransferase activity
FE838_09370	COG1570	exodeoxyribonuclease VII activity
FE838_09380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FE838_09390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FE838_09395	COG0489	protein tyrosine kinase activity
FE838_09405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE838_09440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_09460	COG0714	Associated with various cellular activities
FE838_09465	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FE838_09470	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FE838_09475	COG0039	L-malate dehydrogenase activity
FE838_09510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FE838_09515	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FE838_09520	COG0811	peptide transport
FE838_09525	COG0848	biopolymer transport protein
FE838_09540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FE838_09545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FE838_09550	COG0105	UTP biosynthetic process
FE838_09555	COG0739	heme binding
FE838_09570	COG0149	triose-phosphate isomerase activity
FE838_09580	COG0302	gtp cyclohydrolase
FE838_09585	COG0358	DNA primase activity
FE838_09595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FE838_09600	COG0436	Aminotransferase
FE838_09615	COG0514	ATP-dependent DNA helicase (RecQ)
FE838_09620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FE838_09620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FE838_09640	COG0009	L-threonylcarbamoyladenylate synthase
FE838_09650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FE838_09655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FE838_09660	COG0658	competence protein
FE838_09660	COG2333	competence protein COMEC
FE838_09665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FE838_09675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FE838_09685	COG4771	TonB-dependent receptor
FE838_09690	COG0561	phosphatase activity
FE838_09710	COG3292	Two component regulator propeller
FE838_09710	COG0745	RESPONSE REGULATOR receiver
FE838_09710	COG2205	protein histidine kinase activity
FE838_09715	COG4771	TonB-dependent receptor
FE838_09735	COG3537	Alpha-1,2-mannosidase
FE838_09740	COG3537	Alpha-1,2-mannosidase
FE838_09750	COG3537	Alpha-1,2-mannosidase
FE838_09755	COG3279	Response regulator of the LytR AlgR family
FE838_09760	COG3275	phosphorelay sensor kinase activity
FE838_09765	COG1566	PFAM secretion protein HlyD family protein
FE838_09780	COG0386	Belongs to the glutathione peroxidase family
FE838_09785	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FE838_09790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FE838_09805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FE838_09820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FE838_09825	COG0742	ribosomal rna small subunit methyltransferase
FE838_09840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE838_09845	COG4771	TonB-dependent receptor
FE838_09880	COG3537	Alpha-1,2-mannosidase
FE838_09885	COG3537	Alpha-1,2-mannosidase
FE838_09905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FE838_09910	COG0739	heme binding
FE838_09920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FE838_09925	COG0741	lytic transglycosylase activity
FE838_09925	COG1388	LysM domain
FE838_09935	COG1475	DNA binding
FE838_09940	COG1192	Involved in chromosome partitioning
FE838_09945	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FE838_09950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE838_09960	COG4589	Belongs to the CDS family
FE838_09965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FE838_09970	COG0799	negative regulation of ribosome biogenesis
FE838_10045	COG4974	Belongs to the 'phage' integrase family
FE838_10050	COG4974	Belongs to the 'phage' integrase family
FE838_10055	COG4974	Belongs to the 'phage' integrase family
FE838_10100	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_10135	COG0702	epimerase
FE838_10140	COG1629	transport
FE838_10140	COG4206	TonB-dependent receptor
FE838_10145	COG3291	Pkd domain containing protein
FE838_10145	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_10150	COG1196	nuclear chromosome segregation
FE838_10155	COG2239	Acts as a magnesium transporter
FE838_10160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FE838_10170	COG2195	Cleaves the N-terminal amino acid of tripeptides
FE838_10205	COG1119	ATPase activity
FE838_10215	COG0668	transmembrane transport
FE838_10220	COG0662	Cupin 2, conserved barrel domain protein
FE838_10220	COG2207	Transcriptional regulator
FE838_10245	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE838_10250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FE838_10255	COG0713	ATP synthesis coupled electron transport
FE838_10270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FE838_10275	COG0649	NAD binding
FE838_10275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE838_10280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE838_10285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FE838_10320	COG3250	beta-galactosidase activity
FE838_10330	COG3250	beta-galactosidase activity
FE838_10340	COG2755	lipolytic protein G-D-S-L family
FE838_10340	COG0657	acetylesterase activity
FE838_10355	COG1629	transport
FE838_10360	COG0702	epimerase
FE838_10375	COG0702	epimerase
FE838_10390	COG4771	TonB-dependent receptor
FE838_10395	COG0702	epimerase
FE838_10400	COG1629	transport
FE838_10400	COG4206	TonB-dependent receptor
FE838_10415	COG3537	Alpha-1,2-mannosidase
FE838_10435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FE838_10440	COG0569	domain protein
FE838_10445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FE838_10455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FE838_10460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FE838_10465	COG0805	protein transport
FE838_10475	COG2271	Major facilitator Superfamily
FE838_10480	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FE838_10485	COG3775	system Galactitol-specific IIC component
FE838_10500	COG2755	lipolytic protein G-D-S-L family
FE838_10505	COG0745	RESPONSE REGULATOR receiver
FE838_10505	COG3292	Two component regulator propeller
FE838_10505	COG2205	protein histidine kinase activity
FE838_10515	COG0702	epimerase
FE838_10520	COG4771	TonB-dependent receptor
FE838_10540	COG3279	Response regulator of the LytR AlgR family
FE838_10555	COG1629	transport
FE838_10555	COG4206	TonB-dependent receptor
FE838_10570	COG0745	RESPONSE REGULATOR receiver
FE838_10570	COG2205	protein histidine kinase activity
FE838_10570	COG3292	Two component regulator propeller
FE838_10575	COG1242	4 iron, 4 sulfur cluster binding
FE838_10585	COG0363	glucosamine-6-phosphate deaminase activity
FE838_10590	COG0009	L-threonylcarbamoyladenylate synthase
FE838_10600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE838_10605	COG0561	phosphatase activity
FE838_10625	COG4771	TonB-dependent receptor
FE838_10635	COG3292	Two component regulator propeller
FE838_10635	COG2205	protein histidine kinase activity
FE838_10635	COG0745	RESPONSE REGULATOR receiver
FE838_10640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FE838_10645	COG1408	metallophosphoesterase
FE838_10665	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FE838_10695	COG2755	lipolytic protein G-D-S-L family
FE838_10730	COG3250	beta-galactosidase activity
FE838_10735	COG3345	alpha-galactosidase
FE838_10770	COG4771	TonB-dependent receptor
FE838_10775	COG0702	epimerase
FE838_10790	COG4771	TonB-dependent receptor
FE838_10815	COG2755	lipolytic protein G-D-S-L family
FE838_10825	COG3401	FG-GAP repeat protein
FE838_10835	COG3254	rhamnose metabolic process
FE838_10840	COG2205	protein histidine kinase activity
FE838_10840	COG0745	RESPONSE REGULATOR receiver
FE838_10840	COG3292	Two component regulator propeller
FE838_10840	COG2205	protein histidine kinase activity
FE838_10840	COG0745	RESPONSE REGULATOR receiver
FE838_10840	COG3292	Two component regulator propeller
FE838_10855	COG3250	beta-galactosidase activity
FE838_10860	COG0745	RESPONSE REGULATOR receiver
FE838_10860	COG2205	protein histidine kinase activity
FE838_10860	COG3292	Two component regulator propeller
FE838_10870	COG0546	phosphoglycolate phosphatase activity
FE838_10890	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FE838_10900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FE838_10910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FE838_10915	COG1506	peptidase
FE838_10915	COG0823	Involved in the tonB-independent uptake of proteins
FE838_10965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FE838_10980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FE838_10980	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FE838_10985	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FE838_10990	COG1078	dGTPase activity
FE838_10995	COG0284	orotidine-5'-phosphate decarboxylase activity
FE838_11000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FE838_11010	COG1704	LemA family
FE838_11025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FE838_11030	COG2226	methyltransferase
FE838_11035	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FE838_11040	COG1702	phosphate starvation-inducible protein PhoH
FE838_11050	COG2268	Band 7 protein
FE838_11135	COG0745	RESPONSE REGULATOR receiver
FE838_11135	COG3292	Two component regulator propeller
FE838_11135	COG2205	protein histidine kinase activity
FE838_11140	COG0101	tRNA pseudouridine synthase activity
FE838_11160	COG3250	beta-galactosidase activity
FE838_11165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FE838_11170	COG0673	inositol 2-dehydrogenase activity
FE838_11190	COG4771	TonB-dependent receptor
FE838_11210	COG5434	Belongs to the glycosyl hydrolase 28 family
FE838_11215	COG0673	inositol 2-dehydrogenase activity
FE838_11230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FE838_11240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FE838_11250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FE838_11255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FE838_11260	COG0793	Belongs to the peptidase S41A family
FE838_11265	COG2131	deaminase
FE838_11275	COG0339	signal peptide processing
FE838_11285	COG1970	mechanosensitive ion channel activity
FE838_11290	COG0519	Catalyzes the synthesis of GMP from XMP
FE838_11290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FE838_11300	COG4771	TonB-dependent receptor
FE838_11370	COG0438	transferase activity, transferring glycosyl groups
FE838_11375	COG0463	Glycosyl transferase, family 2
FE838_11460	COG4771	TonB-dependent receptor
FE838_11490	COG0438	transferase activity, transferring glycosyl groups
FE838_11505	COG0297	glycogen (starch) synthase activity
FE838_11510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FE838_11515	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FE838_11520	COG0543	2 iron, 2 sulfur cluster binding
FE838_11530	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FE838_11535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FE838_11540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FE838_11555	COG0791	NLP P60 protein
FE838_11570	COG0612	Peptidase, M16
FE838_11575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FE838_11580	COG1597	lipid kinase activity
FE838_11585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FE838_11600	COG1136	(ABC) transporter
FE838_11620	COG2211	Major facilitator Superfamily
FE838_11625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FE838_11640	COG1674	ftsk spoiiie
FE838_11650	COG0492	ferredoxin-NADP+ reductase activity
FE838_11655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_11690	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FE838_11690	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FE838_11700	COG1234	tRNA 3'-trailer cleavage
FE838_11720	COG3956	TIGRFAM MazG family protein
FE838_11735	COG0525	valine-tRNA ligase activity
FE838_11740	COG0784	Response regulator, receiver
FE838_11740	COG5002	protein histidine kinase activity
FE838_11740	COG2205	protein histidine kinase activity
FE838_11755	COG1629	transport
FE838_11755	COG4206	TonB-dependent receptor
FE838_11780	COG0653	protein targeting
FE838_11785	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
FE838_11800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FE838_11820	COG1253	flavin adenine dinucleotide binding
FE838_11830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FE838_11840	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FE838_11845	COG2204	response regulator
FE838_11885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FE838_11885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FE838_11895	COG3104	oligopeptide transport
FE838_11905	COG0563	adenylate kinase activity
FE838_11910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FE838_11940	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_11945	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_11955	COG2814	Major facilitator Superfamily
FE838_11960	COG0457	Tetratricopeptide repeat
FE838_11965	COG2706	6-phosphogluconolactonase activity
FE838_11995	COG1629	transport
FE838_11995	COG4206	TonB-dependent receptor
FE838_12055	COG3142	Participates in the control of copper homeostasis
FE838_12060	COG1418	mRNA catabolic process
FE838_12090	COG1070	Carbohydrate kinase
FE838_12095	COG1063	alcohol dehydrogenase
FE838_12100	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FE838_12125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FE838_12125	COG1333	cytochrome c biogenesis protein
FE838_12165	COG3328	transposase activity
FE838_12230	COG0673	inositol 2-dehydrogenase activity
FE838_12240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FE838_12245	COG2832	Protein of unknown function (DUF454)
FE838_12255	COG0602	queuosine metabolic process
FE838_12260	COG0247	lactate metabolic process
FE838_12265	COG1139	Iron-sulfur cluster binding protein
FE838_12275	COG0351	phosphomethylpyrimidine kinase
FE838_12285	COG4771	TonB-dependent receptor
FE838_12300	COG4589	Belongs to the CDS family
FE838_12310	COG2304	oxidoreductase activity
FE838_12330	COG1393	Belongs to the ArsC family
FE838_12340	COG4206	TonB-dependent receptor
FE838_12340	COG1629	transport
FE838_12355	COG2233	PERMEase
FE838_12360	COG1509	lysine 2,3-aminomutase activity
FE838_12375	COG1115	amino acid carrier protein
FE838_12430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FE838_12435	COG1388	LysM domain
FE838_12435	COG0741	lytic transglycosylase activity
FE838_12495	COG0534	Mate efflux family protein
FE838_12505	COG0564	pseudouridine synthase activity
FE838_12530	COG0346	lactoylglutathione lyase activity
FE838_12590	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FE838_12595	COG4804	nuclease activity
FE838_12600	COG0732	type I restriction modification DNA specificity domain
FE838_12675	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FE838_12680	COG3586	endonuclease activity
FE838_12695	COG3645	SOS response
FE838_12720	COG0582	viral genome integration into host DNA
FE838_12745	COG4974	Belongs to the 'phage' integrase family
FE838_12760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FE838_12765	COG5002	protein histidine kinase activity
FE838_12765	COG0784	Response regulator, receiver
FE838_12770	COG2910	NAD(P)H-binding
FE838_12780	COG4864	UPF0365 protein
FE838_12795	COG0037	tRNA processing
FE838_12805	COG1477	protein flavinylation
FE838_12810	COG1971	Probably functions as a manganese efflux pump
FE838_12825	COG0463	Glycosyl transferase, family 2
FE838_12840	COG3279	Response regulator of the LytR AlgR family
FE838_12865	COG1595	DNA-templated transcription, initiation
FE838_12870	COG0148	phosphopyruvate hydratase activity
FE838_12880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FE838_12910	COG5433	transposase activity
FE838_12915	COG1082	Xylose isomerase domain protein TIM barrel
FE838_12920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FE838_12925	COG2195	Cleaves the N-terminal amino acid of tripeptides
FE838_12930	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FE838_12935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FE838_12935	COG4651	solute:proton antiporter activity
FE838_12945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FE838_12950	COG0193	aminoacyl-tRNA hydrolase activity
FE838_12955	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FE838_12965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FE838_12970	COG1862	Preprotein translocase
FE838_12980	COG0237	dephospho-CoA kinase activity
FE838_12995	COG0542	response to heat
FE838_13005	COG0583	DNA-binding transcription factor activity
FE838_13020	COG0443	Heat shock 70 kDa protein
FE838_13055	COG2855	membrane
FE838_13060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FE838_13065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FE838_13085	COG0443	Heat shock 70 kDa protein
FE838_13155	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FE838_13170	COG3119	arylsulfatase activity
FE838_13180	COG0702	epimerase
FE838_13185	COG4771	TonB-dependent receptor
FE838_13200	COG0306	phosphate transporter
FE838_13210	COG0586	Pfam SNARE associated Golgi protein
FE838_13265	COG0038	chloride channel
FE838_13270	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FE838_13285	COG1940	carbohydrate kinase activity
FE838_13295	COG3119	arylsulfatase activity
FE838_13305	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FE838_13310	COG0702	epimerase
FE838_13315	COG4771	TonB-dependent receptor
FE838_13325	COG5434	Belongs to the glycosyl hydrolase 28 family
FE838_13330	COG3292	Two component regulator propeller
FE838_13330	COG0745	RESPONSE REGULATOR receiver
FE838_13330	COG2205	protein histidine kinase activity
FE838_13335	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
FE838_13340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FE838_13350	COG3250	beta-galactosidase activity
FE838_13365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FE838_13370	COG1629	transport
FE838_13370	COG4206	TonB-dependent receptor
FE838_13380	COG5002	protein histidine kinase activity
FE838_13405	COG1760	l-serine dehydratase
FE838_13410	COG0598	Magnesium transport protein CorA
FE838_13415	COG1193	negative regulation of DNA recombination
FE838_13425	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_13440	COG3250	beta-galactosidase activity
FE838_13465	COG0668	transmembrane transport
FE838_13470	COG1523	belongs to the glycosyl hydrolase 13 family
FE838_13480	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FE838_13490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_13500	COG1538	Outer membrane efflux protein
FE838_13510	COG0456	acetyltransferase
FE838_13520	COG3189	MarR family transcriptional regulator
FE838_13525	COG0561	phosphatase activity
FE838_13530	COG1169	isochorismate synthase
FE838_13535	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FE838_13540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FE838_13545	COG4948	Mandelate Racemase Muconate Lactonizing
FE838_13565	COG4206	TonB-dependent receptor
FE838_13565	COG1629	transport
FE838_13605	COG0783	Belongs to the Dps family
FE838_13610	COG0583	DNA-binding transcription factor activity
FE838_13620	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FE838_13640	COG1595	DNA-templated transcription, initiation
FE838_13650	COG4771	TonB-dependent receptor
FE838_13660	COG0584	glycerophosphoryl diester phosphodiesterase
FE838_13665	COG0584	glycerophosphoryl diester phosphodiesterase
FE838_13670	COG2271	Major facilitator Superfamily
FE838_13715	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_13720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FE838_13725	COG1882	Formate acetyltransferase
FE838_13735	COG4974	Belongs to the 'phage' integrase family
FE838_13765	COG5290	Psort location Cytoplasmic, score
FE838_13815	COG0326	Molecular chaperone. Has ATPase activity
FE838_13970	COG1475	DNA binding
FE838_13990	COG0584	glycerophosphoryl diester phosphodiesterase
FE838_14035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FE838_14080	COG2198	Histidine kinase
FE838_14080	COG5002	protein histidine kinase activity
FE838_14080	COG0784	Response regulator, receiver
FE838_14145	COG1629	transport
FE838_14145	COG4206	TonB-dependent receptor
FE838_14220	COG1216	Glycosyl transferase, family 2
FE838_14220	COG1442	glycosyl transferase family 8
FE838_14230	COG1215	transferase activity, transferring glycosyl groups
FE838_14235	COG1216	Glycosyl transferase, family 2
FE838_14250	COG1442	glycosyl transferase family 8
FE838_14250	COG1216	Glycosyl transferase, family 2
FE838_14255	COG1216	Glycosyl transferase, family 2
FE838_14270	COG0438	transferase activity, transferring glycosyl groups
FE838_14275	COG0438	transferase activity, transferring glycosyl groups
FE838_14280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FE838_14330	COG2885	chlorophyll binding
FE838_14365	COG4988	ABC transporter
FE838_14390	COG4974	Belongs to the 'phage' integrase family
FE838_14400	COG2003	Belongs to the UPF0758 family
FE838_14540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FE838_14540	COG0551	DNA topoisomerase type I activity
FE838_14585	COG0798	PFAM Bile acid sodium symporter
FE838_14590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FE838_14630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FE838_14670	COG1028	Short-chain dehydrogenase reductase Sdr
FE838_14675	COG3385	transposase activity
FE838_14680	COG1082	Xylose isomerase domain protein TIM barrel
FE838_14685	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FE838_14710	COG3292	Two component regulator propeller
FE838_14710	COG0745	RESPONSE REGULATOR receiver
FE838_14710	COG2205	protein histidine kinase activity
FE838_14710	COG2205	protein histidine kinase activity
FE838_14710	COG0745	RESPONSE REGULATOR receiver
FE838_14710	COG3292	Two component regulator propeller
FE838_14715	COG1595	DNA-templated transcription, initiation
FE838_14720	COG1629	transport
FE838_14720	COG4206	TonB-dependent receptor
FE838_14730	COG5492	domain, Protein
FE838_14745	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FE838_14755	COG1253	flavin adenine dinucleotide binding
FE838_14760	COG0501	Belongs to the peptidase M48B family
FE838_14785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE838_14790	COG0482	sulfurtransferase activity
FE838_14795	COG2197	response regulator
FE838_14820	COG2814	Major facilitator Superfamily
FE838_14825	COG4953	penicillin-binding protein 1C
FE838_14830	COG2373	Large extracellular alpha-helical protein
FE838_14835	COG0545	Peptidyl-prolyl cis-trans isomerase
FE838_14910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FE838_14915	COG0646	methionine synthase
FE838_14915	COG1410	methionine synthase
FE838_14920	COG0778	Nitroreductase
FE838_14925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FE838_14935	COG0572	uridine kinase
FE838_14945	COG4232	protein-disulfide reductase activity
FE838_14950	COG1741	Belongs to the pirin family
FE838_14965	COG4771	TonB-dependent receptor
FE838_14970	COG0702	epimerase
FE838_14995	COG2271	Major facilitator Superfamily
FE838_15015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FE838_15020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FE838_15025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FE838_15030	COG0131	Imidazoleglycerol-phosphate dehydratase
FE838_15040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FE838_15040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FE838_15045	COG4206	TonB-dependent receptor
FE838_15045	COG1629	transport
FE838_15095	COG1773	rubredoxin
FE838_15095	COG1592	Rubrerythrin
FE838_15120	COG1373	ATPase (AAA superfamily
FE838_15130	COG3279	Response regulator of the LytR AlgR family
FE838_15180	COG4974	Belongs to the 'phage' integrase family
FE838_15200	COG3591	Belongs to the peptidase S1B family
FE838_15205	COG3591	Belongs to the peptidase S1B family
FE838_15210	COG0641	radical SAM
FE838_15240	COG0420	3'-5' exonuclease activity
FE838_15250	COG1408	metallophosphoesterase
FE838_15265	COG1410	methionine synthase
FE838_15265	COG0646	methionine synthase
FE838_15275	COG0463	Glycosyl transferase, family 2
FE838_15280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FE838_15290	COG1032	radical SAM domain protein
FE838_15310	COG0363	glucosamine-6-phosphate deaminase activity
FE838_15315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FE838_15355	COG2205	protein histidine kinase activity
FE838_15355	COG0745	RESPONSE REGULATOR receiver
FE838_15355	COG3292	Two component regulator propeller
FE838_15360	COG1629	transport
FE838_15365	COG0702	epimerase
FE838_15380	COG4771	TonB-dependent receptor
FE838_15420	COG3328	transposase activity
FE838_15445	COG0811	peptide transport
FE838_15450	COG0848	biopolymer transport protein
FE838_15500	COG1131	(ABC) transporter
FE838_15535	COG1752	Esterase of the alpha-beta hydrolase superfamily
FE838_15575	COG0508	dehydrogenase complex catalyzes the overall conversion of
FE838_15580	COG0022	dehydrogenase e1 component
FE838_15590	COG2264	protein methyltransferase activity
FE838_15605	COG4206	TonB-dependent receptor
FE838_15605	COG1629	transport
FE838_15620	COG0590	tRNA wobble adenosine to inosine editing
FE838_15625	COG0673	inositol 2-dehydrogenase activity
FE838_15650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
FE838_15690	COG0714	Associated with various cellular activities
FE838_15695	COG2425	protein containing a von Willebrand factor type A (vWA) domain
FE838_15710	COG1501	Belongs to the glycosyl hydrolase 31 family
FE838_15715	COG5012	cobalamin binding
FE838_15745	COG0698	ribose 5-phosphate isomerase
FE838_15750	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FE838_15765	COG1070	Carbohydrate kinase
FE838_15770	COG2160	L-arabinose isomerase activity
FE838_15820	COG0702	epimerase
FE838_15825	COG1629	transport
FE838_15825	COG4206	TonB-dependent receptor
FE838_15830	COG0702	epimerase
FE838_15835	COG4206	TonB-dependent receptor
FE838_15835	COG1629	transport
FE838_15845	COG3292	Two component regulator propeller
FE838_15845	COG2205	protein histidine kinase activity
FE838_15845	COG0745	RESPONSE REGULATOR receiver
FE838_15850	COG3507	Belongs to the glycosyl hydrolase 43 family
FE838_15860	COG3507	Belongs to the glycosyl hydrolase 43 family
FE838_15865	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FE838_15880	COG1482	cell wall glycoprotein biosynthetic process
FE838_15920	COG1086	Polysaccharide biosynthesis protein
FE838_16020	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_16055	COG4221	oxidoreductase activity
FE838_16065	COG1218	3'(2'),5'-bisphosphate nucleotidase
FE838_16070	COG3273	potassium ion transport
FE838_16070	COG0471	metal ion transport
FE838_16075	COG0529	Catalyzes the synthesis of activated sulfate
FE838_16080	COG0175	sulfate reduction
FE838_16085	COG2895	sulfate adenylyltransferase (ATP) activity
FE838_16105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FE838_16110	COG0242	peptide deformylase activity
FE838_16120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FE838_16125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FE838_16130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FE838_16135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FE838_16145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FE838_16150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FE838_16155	COG0674	pyruvate-flavodoxin oxidoreductase activity
FE838_16155	COG1013	pyruvate-flavodoxin oxidoreductase activity
FE838_16155	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FE838_16155	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
FE838_16165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FE838_16180	COG1940	carbohydrate kinase activity
FE838_16185	COG2081	HI0933 family
FE838_16195	COG2814	Major facilitator Superfamily
FE838_16205	COG4771	TonB-dependent receptor
FE838_16240	COG2755	lipolytic protein G-D-S-L family
FE838_16240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FE838_16250	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_16270	COG4771	TonB-dependent receptor
FE838_16295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_16300	COG2755	lipolytic protein G-D-S-L family
FE838_16300	COG0657	acetylesterase activity
FE838_16310	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_16315	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_16320	COG3250	beta-galactosidase activity
FE838_16340	COG1091	dTDP-4-dehydrorhamnose reductase activity
FE838_16390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FE838_16400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FE838_16430	COG4771	TonB-dependent receptor
FE838_16435	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FE838_16445	COG2721	sulfolactate sulfo-lyase activity
FE838_16450	COG1609	Transcriptional regulator
FE838_16485	COG1429	ligase activity, forming nitrogen-metal bonds
FE838_16490	COG4771	TonB-dependent receptor
FE838_16510	COG1230	cation diffusion facilitator family transporter
FE838_16515	COG0490	domain, Protein
FE838_16515	COG2985	domain, Protein
FE838_16525	COG4771	TonB-dependent receptor
FE838_16535	COG4771	TonB-dependent receptor
FE838_16550	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_16565	COG1132	(ABC) transporter
FE838_16605	COG0716	FMN binding
FE838_16610	COG0138	bifunctional purine biosynthesis protein purh
FE838_16625	COG2197	response regulator
FE838_16630	COG0110	maltose O-acetyltransferase activity
FE838_16640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FE838_16645	COG2205	protein histidine kinase activity
FE838_16645	COG0745	RESPONSE REGULATOR receiver
FE838_16645	COG3292	Two component regulator propeller
FE838_16655	COG0252	asparaginase activity
FE838_16660	COG0159	tryptophan synthase activity
FE838_16665	COG0135	phosphoribosylanthranilate isomerase activity
FE838_16670	COG0134	indole-3-glycerol-phosphate synthase activity
FE838_16675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FE838_16685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FE838_16690	COG0133	tryptophan synthase activity
FE838_16705	COG1979	alcohol dehydrogenase
FE838_16720	COG0490	domain, Protein
FE838_16720	COG0471	metal ion transport
FE838_16730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FE838_16745	COG0004	ammonium transporteR
FE838_16750	COG0347	Belongs to the P(II) protein family
FE838_16760	COG0436	Aminotransferase
FE838_16765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FE838_16780	COG0367	asparagine synthase
FE838_16790	COG0070	glutamate synthase
FE838_16790	COG0067	glutamate synthase
FE838_16790	COG0069	glutamate synthase activity
FE838_16795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FE838_16805	COG0505	Belongs to the CarA family
FE838_16810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FE838_16820	COG1917	Cupin 2, conserved barrel domain protein
FE838_16820	COG2207	Transcriptional regulator
FE838_16835	COG1131	(ABC) transporter
FE838_16840	COG0842	Transport permease protein
FE838_16845	COG0842	Transport permease protein
FE838_16855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FE838_16860	COG2949	membrane
FE838_16885	COG0556	nucleotide-excision repair
FE838_16890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FE838_16920	COG1388	LysM domain
FE838_16920	COG3942	CHAP domain
FE838_16930	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FE838_16935	COG3104	oligopeptide transport
FE838_16945	COG1695	Transcriptional regulator
FE838_16950	COG1983	PspC domain protein
FE838_16970	COG1506	peptidase
FE838_16970	COG0823	Involved in the tonB-independent uptake of proteins
FE838_16975	COG0534	Mate efflux family protein
FE838_16980	COG0706	membrane insertase activity
FE838_16985	COG0504	CTP synthase activity
FE838_17040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FE838_17045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FE838_17075	COG0438	transferase activity, transferring glycosyl groups
FE838_17100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FE838_17135	COG4656	Part of a membrane complex involved in electron transport
FE838_17140	COG4658	electron transport chain
FE838_17145	COG4659	FMN binding
FE838_17150	COG4660	Part of a membrane complex involved in electron transport
FE838_17155	COG4657	Part of a membrane complex involved in electron transport
FE838_17160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FE838_17170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FE838_17175	COG0305	Participates in initiation and elongation during chromosome replication
FE838_17180	COG0072	phenylalanine-tRNA ligase activity
FE838_17180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FE838_17185	COG0217	transcriptional regulatory protein
FE838_17205	COG0708	Exodeoxyribonuclease III
FE838_17220	COG0481	GTPase activity
FE838_17230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FE838_17250	COG0024	Methionine aminopeptidase
FE838_17270	COG0564	pseudouridine synthase activity
FE838_17275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FE838_17285	COG0574	Belongs to the PEP-utilizing enzyme family
FE838_17285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FE838_17300	COG0352	thiamine-phosphate diphosphorylase activity
FE838_17305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FE838_17310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FE838_17315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FE838_17320	COG2022	thiamine diphosphate biosynthetic process
FE838_17325	COG0352	thiamine-phosphate diphosphorylase activity
FE838_17335	COG5002	protein histidine kinase activity
FE838_17350	COG0210	DNA helicase
FE838_17405	COG0681	Belongs to the peptidase S26 family
FE838_17415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_17435	COG2249	NAD(P)H dehydrogenase (quinone) activity
FE838_17480	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FE838_17485	COG3118	belongs to the thioredoxin family
FE838_17505	COG2205	protein histidine kinase activity
FE838_17510	COG0745	RESPONSE REGULATOR receiver
FE838_17515	COG1082	Xylose isomerase domain protein TIM barrel
FE838_17520	COG0318	PFAM AMP-dependent synthetase and ligase
FE838_17525	COG3263	regulation of cellular component size
FE838_17530	COG2233	PERMEase
FE838_17535	COG1151	hydroxylamine reductase activity
FE838_17570	COG1136	(ABC) transporter
FE838_17580	COG0534	Mate efflux family protein
FE838_17590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FE838_17600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FE838_17620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
FE838_17630	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_17655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FE838_17660	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FE838_17670	COG0356	it plays a direct role in the translocation of protons across the membrane
FE838_17675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FE838_17680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FE838_17685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FE838_17690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FE838_17695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FE838_17705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FE838_17710	COG2431	L-lysine efflux transmembrane transporter activity
FE838_17725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE838_17740	COG2207	Transcriptional regulator
FE838_17780	COG2985	domain, Protein
FE838_17785	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FE838_17790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FE838_17805	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
FE838_17810	COG0540	Belongs to the ATCase OTCase family
FE838_17825	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FE838_17840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FE838_17845	COG2205	protein histidine kinase activity
FE838_17870	COG4206	TonB-dependent receptor
FE838_17870	COG1629	transport
FE838_17885	COG3250	beta-galactosidase activity
FE838_17890	COG3153	acetyltransferase
FE838_17905	COG3292	Two component regulator propeller
FE838_17905	COG2205	protein histidine kinase activity
FE838_17905	COG0745	RESPONSE REGULATOR receiver
FE838_17935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE838_17945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FE838_17950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FE838_17965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FE838_17990	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
FE838_18000	COG2326	polyphosphate kinase activity
FE838_18045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FE838_18050	COG0045	succinate-CoA ligase (ADP-forming) activity
FE838_18055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FE838_18060	COG0351	phosphomethylpyrimidine kinase
FE838_18075	COG2115	Belongs to the xylose isomerase family
FE838_18080	COG2814	Major facilitator Superfamily
FE838_18080	COG0477	Major facilitator Superfamily
FE838_18125	COG0798	PFAM Bile acid sodium symporter
FE838_18130	COG3153	acetyltransferase
FE838_18130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FE838_18140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FE838_18150	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FE838_18165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FE838_18195	COG3015	lipoprotein NlpE involved in copper resistance
FE838_18200	COG0784	Response regulator, receiver
FE838_18200	COG2198	Histidine kinase
FE838_18200	COG2205	protein histidine kinase activity
FE838_18220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FE838_18235	COG1904	glucuronate isomerase
FE838_18245	COG0246	Mannitol dehydrogenase
FE838_18275	COG0513	Belongs to the DEAD box helicase family
FE838_18280	COG3830	Belongs to the UPF0237 family
FE838_18280	COG0560	Phosphoserine phosphatase
FE838_18305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FE838_18310	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FE838_18395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FE838_18405	COG3852	Histidine kinase
FE838_18430	COG1136	(ABC) transporter
FE838_18465	COG4771	TonB-dependent receptor
FE838_18480	COG0156	8-amino-7-oxononanoate synthase activity
FE838_18485	COG1597	lipid kinase activity
FE838_18490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FE838_18520	COG1132	(ABC) transporter
FE838_18540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FE838_18570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FE838_18585	COG0543	2 iron, 2 sulfur cluster binding
FE838_18590	COG0167	dihydroorotate dehydrogenase activity
FE838_18595	COG0336	Belongs to the RNA methyltransferase TrmD family
FE838_18600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FE838_18605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FE838_18630	COG0326	Molecular chaperone. Has ATPase activity
FE838_18685	COG2304	oxidoreductase activity
FE838_18700	COG0714	Associated with various cellular activities
FE838_18705	COG0776	regulation of translation
FE838_18715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FE838_18720	COG0552	protein localization to endoplasmic reticulum
FE838_18730	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FE838_18735	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FE838_18760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FE838_18795	COG2205	protein histidine kinase activity
FE838_18800	COG0745	RESPONSE REGULATOR receiver
FE838_18805	COG0442	prolyl-tRNA aminoacylation
FE838_18915	COG0582	viral genome integration into host DNA
FE838_18950	COG4974	Belongs to the 'phage' integrase family
FE838_18965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_18980	COG2205	protein histidine kinase activity
FE838_18980	COG3292	Two component regulator propeller
FE838_18980	COG0745	RESPONSE REGULATOR receiver
FE838_18990	COG4206	TonB-dependent receptor
FE838_19020	COG1595	DNA-templated transcription, initiation
FE838_19040	COG1011	Hydrolase
FE838_19050	COG0300	oxidoreductase activity
FE838_19065	COG2966	Psort location CytoplasmicMembrane, score
FE838_19095	COG0745	RESPONSE REGULATOR receiver
FE838_19095	COG3292	Two component regulator propeller
FE838_19095	COG2205	protein histidine kinase activity
FE838_19105	COG3250	beta-galactosidase activity
FE838_19135	COG5002	protein histidine kinase activity
FE838_19140	COG0745	RESPONSE REGULATOR receiver
FE838_19150	COG3250	beta-galactosidase activity
FE838_19170	COG3250	beta-galactosidase activity
FE838_19180	COG2205	protein histidine kinase activity
FE838_19180	COG5002	protein histidine kinase activity
FE838_19180	COG0784	Response regulator, receiver
FE838_19235	COG2755	lipolytic protein G-D-S-L family
FE838_19235	COG0657	acetylesterase activity
FE838_19240	COG0167	dihydroorotate dehydrogenase activity
FE838_19250	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FE838_19260	COG3408	Glycogen debranching enzyme
FE838_19270	COG1028	Short-chain dehydrogenase reductase Sdr
FE838_19290	COG3408	Glycogen debranching enzyme
FE838_19315	COG0702	epimerase
FE838_19320	COG4206	TonB-dependent receptor
FE838_19320	COG1629	transport
FE838_19335	COG0702	epimerase
FE838_19340	COG1629	transport
FE838_19355	COG3537	Alpha-1,2-mannosidase
FE838_19360	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FE838_19395	COG4206	TonB-dependent receptor
FE838_19395	COG1629	transport
FE838_19425	COG4206	TonB-dependent receptor
FE838_19425	COG1629	transport
FE838_19450	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_19470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FE838_19535	COG1475	DNA binding
FE838_19540	COG3969	phosphoadenosine phosphosulfate
FE838_19565	COG3275	phosphorelay sensor kinase activity
FE838_19585	COG1678	Uncharacterized ACR, COG1678
FE838_19600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FE838_19610	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FE838_19640	COG0321	lipoyl(octanoyl) transferase activity
FE838_19650	COG2217	Heavy metal translocating P-type atpase
FE838_19700	COG0010	Belongs to the arginase family
FE838_19705	COG0058	SHG alpha-glucan phosphorylase activity
FE838_19710	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FE838_19710	COG4651	solute:proton antiporter activity
FE838_19715	COG0205	6-phosphofructokinase activity
FE838_19730	COG0588	phosphoglycerate mutase activity
FE838_19735	COG1830	Aldolase
FE838_19745	COG2095	MarC family integral membrane protein
FE838_19800	COG0667	Aldo Keto reductase
FE838_19815	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FE838_19820	COG4771	TonB-dependent receptor
FE838_19835	COG2706	6-phosphogluconolactonase activity
FE838_19840	COG2207	Transcriptional regulator
FE838_19920	COG4974	Belongs to the 'phage' integrase family
FE838_19960	COG0357	Ribosomal RNA small subunit methyltransferase G
FE838_19965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FE838_19970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FE838_19970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FE838_19975	COG0778	Nitroreductase
FE838_19985	COG1739	Uncharacterized protein family UPF0029
FE838_20000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FE838_20010	COG2871	sodium ion transport
FE838_20015	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FE838_20025	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FE838_20030	COG1805	sodium ion transport
FE838_20070	COG1215	transferase activity, transferring glycosyl groups
FE838_20080	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_20120	COG1442	glycosyl transferase family 8
FE838_20120	COG1216	Glycosyl transferase, family 2
FE838_20125	COG2244	polysaccharide biosynthetic process
FE838_20135	COG1442	glycosyl transferase family 8
FE838_20145	COG1215	transferase activity, transferring glycosyl groups
FE838_20170	COG0488	(ABC) transporter
FE838_20190	COG1162	GTPase activity
FE838_20200	COG2755	lipolytic protein G-D-S-L family
FE838_20200	COG0657	acetylesterase activity
FE838_20205	COG0534	Mate efflux family protein
FE838_20210	COG2885	chlorophyll binding
FE838_20215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FE838_20230	COG1704	LemA family
FE838_20235	COG0501	Belongs to the peptidase M48B family
FE838_20260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FE838_20270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FE838_20300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_20305	COG1136	(ABC) transporter
FE838_20310	COG1136	(ABC) transporter
FE838_20310	COG0577	efflux transmembrane transporter activity
FE838_20320	COG3279	Response regulator of the LytR AlgR family
FE838_20330	COG2135	peptidase activity
FE838_20335	COG2837	iron assimilation
FE838_20345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FE838_20350	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FE838_20355	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FE838_20360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FE838_20365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE838_20370	COG0318	PFAM AMP-dependent synthetase and ligase
FE838_20380	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FE838_20385	COG0490	domain, Protein
FE838_20385	COG2985	domain, Protein
FE838_20430	COG0737	Belongs to the 5'-nucleotidase family
FE838_20435	COG2205	protein histidine kinase activity
FE838_20435	COG2202	Pas domain
FE838_20440	COG2183	response to ionizing radiation
FE838_20460	COG0488	(ABC) transporter
FE838_20465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FE838_20470	COG0484	heat shock protein binding
FE838_20550	COG1733	regulation of RNA biosynthetic process
FE838_20560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FE838_20560	COG0784	Response regulator, receiver
FE838_20560	COG2198	Histidine kinase
FE838_20560	COG2205	protein histidine kinase activity
FE838_20570	COG3275	phosphorelay sensor kinase activity
FE838_20595	COG0228	four-way junction DNA binding
FE838_20600	COG2188	Transcriptional regulator
FE838_20605	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
FE838_20615	COG1070	Carbohydrate kinase
FE838_20625	COG0738	Major facilitator superfamily
FE838_20670	COG2207	Transcriptional regulator
FE838_20685	COG1177	transmembrane transport
FE838_20690	COG1176	ABC-type spermidine putrescine transport system, permease component I
FE838_20695	COG3842	ATPase activity
FE838_20700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FE838_20705	COG0058	SHG alpha-glucan phosphorylase activity
FE838_20715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FE838_20735	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
FE838_20760	COG1725	Transcriptional regulator
FE838_20770	COG1131	(ABC) transporter
FE838_20820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FE838_20825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FE838_20830	COG4948	Mandelate Racemase Muconate Lactonizing
FE838_20845	COG1295	ribonuclease BN
FE838_20860	COG2972	Histidine kinase
FE838_20870	COG0704	Plays a role in the regulation of phosphate uptake
FE838_20875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FE838_20880	COG0581	inorganic phosphate transmembrane transporter activity
FE838_20885	COG0573	inorganic phosphate transmembrane transporter activity
FE838_20895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FE838_20905	COG0586	Pfam SNARE associated Golgi protein
FE838_20915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FE838_20930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FE838_20935	COG0167	dihydroorotate dehydrogenase activity
FE838_20940	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FE838_20965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FE838_21025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FE838_21035	COG1216	Glycosyl transferase, family 2
FE838_21070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FE838_21075	COG0497	DNA recombination
FE838_21090	COG0592	DNA-directed DNA polymerase activity
FE838_21105	COG0321	lipoyl(octanoyl) transferase activity
FE838_21105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FE838_21110	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FE838_21120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FE838_21125	COG0156	8-amino-7-oxononanoate synthase activity
FE838_21140	COG0019	diaminopimelate decarboxylase activity
FE838_21145	COG0527	aspartate kinase activity
FE838_21150	COG2884	Cell division ATP-binding protein ftsE
FE838_21155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FE838_21155	COG0140	phosphoribosyl-ATP diphosphatase activity
FE838_21160	COG0107	imidazoleglycerol-phosphate synthase activity
FE838_21165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FE838_21170	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FE838_21175	COG0788	formyltetrahydrofolate deformylase activity
FE838_21190	COG0693	protein deglycase activity
FE838_21195	COG0656	L-ascorbic acid biosynthetic process
FE838_21215	COG0534	Mate efflux family protein
FE838_21220	COG2076	Multidrug Resistance protein
FE838_21235	COG2885	chlorophyll binding
FE838_21235	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FE838_21270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FE838_21285	COG2814	Major facilitator Superfamily
FE838_21310	COG1309	transcriptional regulator
FE838_21315	COG1924	4 iron, 4 sulfur cluster binding
FE838_21335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FE838_21340	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FE838_21355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FE838_21365	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FE838_21380	COG4771	TonB-dependent receptor
FE838_21440	COG1312	Catalyzes the dehydration of D-mannonate
FE838_21445	COG1028	Short-chain dehydrogenase reductase Sdr
FE838_21450	COG1609	Transcriptional regulator
FE838_21465	COG1929	Belongs to the glycerate kinase type-1 family
FE838_21470	COG2223	nitrite transmembrane transporter activity
FE838_21480	COG4771	TonB-dependent receptor
FE838_21490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FE838_21490	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FE838_21505	COG2226	methyltransferase
FE838_21515	COG5002	protein histidine kinase activity
FE838_21515	COG0784	Response regulator, receiver
FE838_21520	COG0511	ligase activity, forming carbon-carbon bonds
FE838_21525	COG0439	Biotin carboxylase
FE838_21530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FE838_21545	COG1620	l-lactate permease
FE838_21550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FE838_21555	COG1690	Belongs to the RtcB family
FE838_21600	COG0110	maltose O-acetyltransferase activity
FE838_21610	COG0577	efflux transmembrane transporter activity
FE838_21615	COG0577	efflux transmembrane transporter activity
FE838_21615	COG1136	(ABC) transporter
FE838_21640	COG0628	permease
FE838_21645	COG1215	transferase activity, transferring glycosyl groups
FE838_21655	COG0569	domain protein
FE838_21655	COG0189	ligase activity
FE838_21660	COG1136	(ABC) transporter
FE838_21660	COG0577	efflux transmembrane transporter activity
FE838_21665	COG0436	Aminotransferase
FE838_21680	COG0488	(ABC) transporter
FE838_21695	COG0745	RESPONSE REGULATOR receiver
FE838_21700	COG5002	protein histidine kinase activity
FE838_21745	COG3033	Beta-eliminating lyase
FE838_21770	COG0629	single-stranded DNA binding
FE838_21775	COG1194	a g-specific adenine glycosylase
FE838_21785	COG1530	ribonuclease E activity
FE838_21790	COG2885	chlorophyll binding
FE838_21815	COG2885	chlorophyll binding
FE838_21880	COG0305	Participates in initiation and elongation during chromosome replication
FE838_21895	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_21915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FE838_21925	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FE838_21940	COG4191	Histidine kinase
FE838_21945	COG2204	response regulator
FE838_21955	COG5002	protein histidine kinase activity
FE838_21955	COG0784	Response regulator, receiver
FE838_21955	COG2205	protein histidine kinase activity
FE838_21985	COG1252	NADH dehydrogenase
FE838_21990	COG1705	Flagellar rod assembly protein muramidase FlgJ
FE838_22005	COG3059	membrane
FE838_22010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FE838_22015	COG0488	(ABC) transporter
FE838_22040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FE838_22050	COG0739	heme binding
FE838_22055	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FE838_22060	COG1629	transport
FE838_22060	COG4206	TonB-dependent receptor
FE838_22070	COG0686	Belongs to the AlaDH PNT family
FE838_22115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FE838_22125	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FE838_22135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FE838_22165	COG1595	DNA-templated transcription, initiation
FE838_22180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FE838_22185	COG1741	Belongs to the pirin family
FE838_22190	COG0259	pyridoxamine-phosphate oxidase activity
FE838_22245	COG0456	acetyltransferase
FE838_22290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FE838_22290	COG1918	ferrous iron import across plasma membrane
FE838_22295	COG0037	tRNA processing
FE838_22310	COG3119	arylsulfatase activity
FE838_22315	COG2205	protein histidine kinase activity
FE838_22315	COG2202	Pas domain
FE838_22320	COG2205	protein histidine kinase activity
FE838_22320	COG2202	Pas domain
FE838_22325	COG0534	Mate efflux family protein
FE838_22330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FE838_22350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FE838_22355	COG1858	cytochrome C peroxidase
FE838_22360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FE838_22375	COG1983	PspC domain protein
FE838_22380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FE838_22405	COG2195	Cleaves the N-terminal amino acid of tripeptides
FE838_22425	COG4206	TonB-dependent receptor
FE838_22425	COG1629	transport
FE838_22440	COG3119	arylsulfatase activity
FE838_22445	COG0668	transmembrane transport
FE838_22450	COG3119	arylsulfatase activity
FE838_22460	COG3250	beta-galactosidase activity
FE838_22465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FE838_22470	COG3119	arylsulfatase activity
FE838_22480	COG0702	epimerase
FE838_22485	COG1629	transport
FE838_22485	COG4206	TonB-dependent receptor
FE838_22495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FE838_22500	COG1660	Displays ATPase and GTPase activities
FE838_22505	COG2205	protein histidine kinase activity
FE838_22505	COG2205	protein histidine kinase activity
FE838_22505	COG3292	Two component regulator propeller
FE838_22505	COG0745	RESPONSE REGULATOR receiver
FE838_22505	COG3292	Two component regulator propeller
FE838_22505	COG0745	RESPONSE REGULATOR receiver
FE838_22510	COG3119	arylsulfatase activity
FE838_22555	COG1216	Glycosyl transferase, family 2
FE838_22560	COG1216	Glycosyl transferase, family 2
FE838_22570	COG1442	glycosyl transferase family 8
FE838_22570	COG1216	Glycosyl transferase, family 2
FE838_22580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FE838_22590	COG2244	polysaccharide biosynthetic process
FE838_22620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FE838_22625	COG1830	Aldolase
FE838_22630	COG0588	phosphoglycerate mutase activity
FE838_22635	COG0784	Response regulator, receiver
FE838_22635	COG2205	protein histidine kinase activity
FE838_22640	COG1119	ATPase activity
FE838_22645	COG1523	belongs to the glycosyl hydrolase 13 family
FE838_22650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FE838_22665	COG0560	Phosphoserine phosphatase
FE838_22680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FE838_22685	COG2814	Major facilitator Superfamily
FE838_22690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FE838_22695	COG0126	phosphoglycerate kinase activity
FE838_22715	COG0424	maF-like protein
FE838_22735	COG0778	Nitroreductase
FE838_22745	COG0288	reversible hydration of carbon dioxide
FE838_22755	COG4771	TonB-dependent receptor
FE838_22770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FE838_22780	COG0511	ligase activity, forming carbon-carbon bonds
FE838_22785	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FE838_22795	COG0191	fructose-bisphosphate aldolase activity
FE838_22800	COG0254	rRNA binding
FE838_22805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_22810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FE838_22880	COG1216	Glycosyl transferase, family 2
FE838_22900	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FE838_22910	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
FE838_22915	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FE838_22940	COG4750	Nucleotidyl transferase
FE838_22980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FE838_22995	COG1280	lysine exporter protein (LysE YggA)
FE838_23005	COG3292	Two component regulator propeller
FE838_23005	COG0745	RESPONSE REGULATOR receiver
FE838_23005	COG2205	protein histidine kinase activity
FE838_23005	COG3292	Two component regulator propeller
FE838_23005	COG0745	RESPONSE REGULATOR receiver
FE838_23005	COG2205	protein histidine kinase activity
FE838_23020	COG1649	PFAM Uncharacterised BCR, COG1649
FE838_23045	COG1966	Carbon starvation protein
FE838_23080	COG2113	Glycine betaine
FE838_23085	COG4176	ABC-type proline glycine betaine transport system permease component
FE838_23105	COG0745	RESPONSE REGULATOR receiver
FE838_23105	COG3292	Two component regulator propeller
FE838_23105	COG2205	protein histidine kinase activity
FE838_23120	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FE838_23120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FE838_23130	COG1621	beta-fructofuranosidase activity
FE838_23145	COG0561	phosphatase activity
FE838_23150	COG4206	TonB-dependent receptor
FE838_23150	COG1629	transport
FE838_23160	COG1621	beta-fructofuranosidase activity
FE838_23175	COG3250	beta-galactosidase activity
FE838_23180	COG3537	Alpha-1,2-mannosidase
FE838_23215	COG1629	transport
FE838_23225	COG3250	beta-galactosidase activity
FE838_23235	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_23245	COG1472	Belongs to the glycosyl hydrolase 3 family
FE838_23260	COG1752	Esterase of the alpha-beta hydrolase superfamily
FE838_23265	COG0475	glutathione-regulated potassium exporter activity
FE838_23305	COG2885	chlorophyll binding
FE838_23325	COG3279	Response regulator of the LytR AlgR family
FE838_23360	COG2205	protein histidine kinase activity
FE838_23365	COG2205	protein histidine kinase activity
FE838_23380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FE838_23385	COG1960	acyl-CoA dehydrogenase activity
FE838_23405	COG1956	GAF domain-containing protein
FE838_23415	COG0484	heat shock protein binding
FE838_23420	COG2194	sulfuric ester hydrolase activity
FE838_23460	COG3385	transposase activity
FE838_23500	COG0459	protein refolding
FE838_23505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FE838_23520	COG2205	protein histidine kinase activity
FE838_23520	COG0784	Response regulator, receiver
FE838_23520	COG5002	protein histidine kinase activity
FE838_23530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FE838_23540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FE838_23545	COG1506	peptidase
FE838_23545	COG0823	Involved in the tonB-independent uptake of proteins
FE838_23555	COG0124	histidyl-tRNA synthetase
FE838_23570	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FE838_23595	COG0514	ATP-dependent DNA helicase (RecQ)
FE838_23615	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FE838_23625	COG0671	phosphoesterase, PA-phosphatase related
FE838_23640	COG0473	3-isopropylmalate dehydrogenase activity
FE838_23645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FE838_23650	COG0066	3-isopropylmalate dehydratase activity
FE838_23655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FE838_23660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FE838_23710	COG4948	Mandelate Racemase Muconate Lactonizing
FE838_23720	COG3507	Belongs to the glycosyl hydrolase 43 family
FE838_23725	COG0702	epimerase
FE838_23730	COG4771	TonB-dependent receptor
FE838_23750	COG0616	signal peptide processing
FE838_23755	COG1663	tetraacyldisaccharide 4'-kinase activity
FE838_23760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FE838_23765	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FE838_23785	COG0513	Belongs to the DEAD box helicase family
FE838_23790	COG2070	2-Nitropropane dioxygenase
FE838_23795	COG0724	RNA recognition motif
FE838_23810	COG3973	AAA domain
FE838_23830	COG5433	transposase activity
FE838_23850	COG1704	LemA family
FE838_23865	COG0534	Mate efflux family protein
FE838_23875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FE838_23885	COG1917	Cupin 2, conserved barrel domain protein
FE838_23885	COG4977	sequence-specific DNA binding
FE838_23920	COG1028	Short-chain dehydrogenase reductase Sdr
FE838_23930	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FE838_23945	COG0439	Biotin carboxylase
FE838_23950	COG0511	ligase activity, forming carbon-carbon bonds
FE838_23950	COG5016	pyruvate
FE838_23955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FE838_23965	COG2855	membrane
FE838_23980	COG2873	o-acetylhomoserine
FE838_24015	COG4974	Belongs to the 'phage' integrase family
FE838_24020	COG4974	Belongs to the 'phage' integrase family
FE838_24115	COG1192	Involved in chromosome partitioning
FE838_24145	COG1120	ATPase activity
FE838_24150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FE838_24215	COG1538	Outer membrane efflux protein
FE838_24245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FE838_24265	COG0024	Methionine aminopeptidase
FE838_24275	COG0617	tRNA 3'-terminal CCA addition
FE838_24295	COG0632	four-way junction helicase activity
FE838_24300	COG0673	inositol 2-dehydrogenase activity
FE838_24320	COG1272	protein, Hemolysin III
FE838_24335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FE838_24360	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_24385	COG3328	transposase activity
FE838_24395	COG1328	CTP reductase activity
FE838_24405	COG2814	Major facilitator Superfamily
FE838_24410	COG0750	zinc metalloprotease
FE838_24415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FE838_24425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FE838_24430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FE838_24450	COG0194	GDP metabolic process
FE838_24460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FE838_24470	COG1408	metallophosphoesterase
FE838_24475	COG1575	Belongs to the MenA family. Type 1 subfamily
FE838_24480	COG1088	dTDP-glucose 4,6-dehydratase activity
FE838_24485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FE838_24495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FE838_24515	COG2205	protein histidine kinase activity
FE838_24540	COG3023	N-Acetylmuramoyl-L-alanine amidase
FE838_24565	COG4771	TonB-dependent receptor
FE838_24570	COG1629	transport
FE838_24580	COG2205	protein histidine kinase activity
FE838_24580	COG0784	Response regulator, receiver
FE838_24585	COG0488	(ABC) transporter
FE838_24635	COG1595	DNA-templated transcription, initiation
FE838_24650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FE838_24660	COG1522	sequence-specific DNA binding
FE838_24690	COG0811	peptide transport
FE838_24700	COG0084	hydrolase, TatD family'
FE838_24720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FE838_24725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FE838_24730	COG0205	6-phosphofructokinase activity
FE838_24755	COG1902	pentaerythritol trinitrate reductase activity
FE838_24770	COG0372	Belongs to the citrate synthase family
FE838_24775	COG0538	isocitrate dehydrogenase activity
FE838_24785	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
FE838_24790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FE838_24805	COG0028	Belongs to the TPP enzyme family
FE838_24810	COG0129	dihydroxy-acid dehydratase activity
FE838_24815	COG1047	Peptidyl-prolyl cis-trans
FE838_24820	COG3681	Belongs to the UPF0597 family
FE838_24840	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FE838_24845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FE838_24870	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FE838_24870	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FE838_24875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FE838_24880	COG2985	domain, Protein
FE838_24880	COG0569	domain protein
FE838_24915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FE838_24920	COG1120	ATPase activity
FE838_24935	COG2188	Transcriptional regulator
FE838_24955	COG4206	TonB-dependent receptor
FE838_24955	COG1629	transport
FE838_25015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FE838_25020	COG1609	Transcriptional regulator
FE838_25020	COG2207	Transcriptional regulator
FE838_25030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FE838_25035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FE838_25040	COG0166	Belongs to the GPI family
FE838_25070	COG2502	aspartate--ammonia ligase
FE838_25075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FE838_25100	COG3876	Protein conserved in bacteria
FE838_25130	COG0860	N-Acetylmuramoyl-L-alanine amidase