locus-tag	class	description
AL474_00015	COG2988	succinylglutamate desuccinylase activity
AL474_00045	COG0765	amino acid transport
AL474_00050	COG0765	amino acid transport
AL474_00055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_00090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL474_00095	COG1595	DNA-templated transcription, initiation
AL474_00105	COG3530	Putative quorum-sensing-regulated virulence factor
AL474_00110	COG0494	nUDIX hydrolase
AL474_00125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AL474_00130	COG0542	response to heat
AL474_00145	COG3468	outer membrane autotransporter barrel domain protein
AL474_00155	COG5441	Belongs to the UPF0261 family
AL474_00160	COG5564	TIM-barrel signal transduction protein
AL474_00175	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AL474_00190	COG1477	protein flavinylation
AL474_00210	COG1131	(ABC) transporter
AL474_00215	COG0842	Transport permease protein
AL474_00225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL474_00235	COG1562	ergosterol biosynthetic process
AL474_00240	COG1562	ergosterol biosynthetic process
AL474_00245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL474_00250	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_00270	COG2304	oxidoreductase activity
AL474_00300	COG0254	rRNA binding
AL474_00305	COG3483	tryptophan 2,3-dioxygenase activity
AL474_00310	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AL474_00315	COG2003	Belongs to the UPF0758 family
AL474_00320	COG1047	Peptidyl-prolyl cis-trans
AL474_00330	COG0625	glutathione transferase activity
AL474_00350	COG0523	cobalamin synthesis protein
AL474_00360	COG0583	DNA-binding transcription factor activity
AL474_00370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AL474_00380	COG0779	Required for maturation of 30S ribosomal subunits
AL474_00385	COG0195	Participates in both transcription termination and antitermination
AL474_00385	COG2251	uridine kinase activity
AL474_00390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL474_00395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL474_00400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL474_00420	COG1611	Belongs to the LOG family
AL474_00435	COG0412	Dienelactone hydrolase
AL474_00440	COG1283	sodium-dependent phosphate transmembrane transporter activity
AL474_00445	COG1760	l-serine dehydratase
AL474_00450	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL474_00455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AL474_00465	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL474_00475	COG0187	DNA topoisomerase II activity
AL474_00515	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL474_00535	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_00550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL474_00560	COG1653	transport
AL474_00565	COG1175	transmembrane transport
AL474_00570	COG0395	ABC-type sugar transport system, permease component
AL474_00575	COG3842	ATPase activity
AL474_00600	COG2363	Small membrane protein
AL474_00640	COG0095	Lipoate-protein ligase
AL474_00655	COG0625	glutathione transferase activity
AL474_00660	COG0386	Belongs to the glutathione peroxidase family
AL474_00680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_00710	COG2259	Doxx family
AL474_00755	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AL474_00790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AL474_00845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL474_00850	COG3568	Endonuclease Exonuclease Phosphatase
AL474_00855	COG1695	Transcriptional regulator
AL474_00875	COG0583	DNA-binding transcription factor activity
AL474_00890	COG1802	Transcriptional regulator
AL474_00900	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_00910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_00925	COG0066	3-isopropylmalate dehydratase activity
AL474_00935	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_00940	COG4948	Mandelate Racemase Muconate Lactonizing
AL474_00955	COG1126	abc transporter atp-binding protein
AL474_00965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_01005	COG1815	bacterial-type flagellum-dependent cell motility
AL474_01010	COG1558	bacterial-type flagellum-dependent cell motility
AL474_01015	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AL474_01020	COG1749	Flagellar hook protein flgE
AL474_01030	COG4786	Flagellar basal body rod
AL474_01035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AL474_01040	COG1706	bacterial-type flagellum-dependent cell motility
AL474_01050	COG1256	bacterial-type flagellum assembly
AL474_01060	COG0840	transmembrane signaling receptor activity
AL474_01065	COG0840	transmembrane signaling receptor activity
AL474_01070	COG0840	transmembrane signaling receptor activity
AL474_01090	COG1338	Plays a role in the flagellum-specific transport system
AL474_01110	COG1580	Controls the rotational direction of flagella during chemotaxis
AL474_01135	COG1157	protein secretion by the type III secretion system
AL474_01145	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL474_01155	COG1677	Flagellar hook-basal body complex protein FliE
AL474_01165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AL474_01205	COG0285	dihydrofolate synthase activity
AL474_01235	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AL474_01240	COG0024	Methionine aminopeptidase
AL474_01245	COG0052	Belongs to the universal ribosomal protein uS2 family
AL474_01250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL474_01255	COG0528	UMP kinase activity
AL474_01260	COG0233	cytoplasmic translational termination
AL474_01265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL474_01275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AL474_01280	COG0750	zinc metalloprotease
AL474_01285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL474_01290	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
AL474_01295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL474_01300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL474_01310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL474_01315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL474_01320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL474_01325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL474_01335	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL474_01335	COG0519	Catalyzes the synthesis of GMP from XMP
AL474_01350	COG0330	HflC and HflK could
AL474_01355	COG3706	GGDEF domain
AL474_01360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL474_01370	COG2867	negative regulation of translational initiation
AL474_01380	COG1960	acyl-CoA dehydrogenase activity
AL474_01385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL474_01415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL474_01420	COG0505	Belongs to the CarA family
AL474_01425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL474_01435	COG0406	alpha-ribazole phosphatase activity
AL474_01445	COG3842	ATPase activity
AL474_01465	COG5001	Diguanylate cyclase
AL474_01470	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL474_01475	COG4783	chaperone-mediated protein folding
AL474_01480	COG1763	Mo-molybdopterin cofactor biosynthetic process
AL474_01485	COG0303	'Molybdopterin
AL474_01490	COG0746	molybdenum cofactor guanylyltransferase activity
AL474_01495	COG0489	protein tyrosine kinase activity
AL474_01525	COG3383	formate dehydrogenase (NAD+) activity
AL474_01525	COG0243	molybdopterin cofactor binding
AL474_01560	COG1122	ATPase activity
AL474_01570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL474_01575	COG0066	3-isopropylmalate dehydratase activity
AL474_01580	COG0473	3-isopropylmalate dehydrogenase activity
AL474_01585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL474_01595	COG0101	tRNA pseudouridine synthase activity
AL474_01600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL474_01615	COG0135	phosphoribosylanthranilate isomerase activity
AL474_01630	COG3022	response to hydroperoxide
AL474_01645	COG3023	N-Acetylmuramoyl-L-alanine amidase
AL474_01655	COG0424	maF-like protein
AL474_01660	COG1399	metal-binding, possibly nucleic acid-binding protein
AL474_01665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL474_01670	COG0416	fatty acid biosynthetic process
AL474_01675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL474_01690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL474_01695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AL474_01720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL474_01725	COG0481	GTPase activity
AL474_01730	COG0681	Belongs to the peptidase S26 family
AL474_01735	COG0571	ribonuclease III activity
AL474_01740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL474_01745	COG1381	Involved in DNA repair and RecF pathway recombination
AL474_01770	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_01775	COG0670	Belongs to the BI1 family
AL474_01790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL474_01800	COG0583	DNA-binding transcription factor activity
AL474_01815	COG0583	DNA-binding transcription factor activity
AL474_01830	COG0791	NLP P60 protein
AL474_01840	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AL474_01850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL474_01855	COG0697	spore germination
AL474_01860	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AL474_01905	COG1446	asparaginase
AL474_01910	COG4172	Belongs to the ABC transporter superfamily
AL474_01915	COG0747	negative chemotaxis
AL474_01925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_01950	COG0504	CTP synthase activity
AL474_01965	COG0148	phosphopyruvate hydratase activity
AL474_01970	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AL474_02000	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL474_02010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL474_02065	COG0039	L-malate dehydrogenase activity
AL474_02070	COG2188	Transcriptional regulator
AL474_02075	COG2009	succinate dehydrogenase
AL474_02080	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AL474_02085	COG1053	succinate dehydrogenase
AL474_02090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL474_02095	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AL474_02100	COG0372	Belongs to the citrate synthase family
AL474_02130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL474_02135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AL474_02145	COG3642	lipopolysaccharide core region biosynthetic process
AL474_02150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AL474_02155	COG3842	ATPase activity
AL474_02160	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL474_02165	COG1177	transmembrane transport
AL474_02175	COG2094	Belongs to the DNA glycosylase MPG family
AL474_02190	COG1960	acyl-CoA dehydrogenase activity
AL474_02195	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL474_02200	COG0704	Plays a role in the regulation of phosphate uptake
AL474_02210	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AL474_02215	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AL474_02215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL474_02220	COG1643	Atp-dependent helicase
AL474_02235	COG0438	transferase activity, transferring glycosyl groups
AL474_02240	COG0726	polysaccharide deacetylase
AL474_02245	COG0463	Glycosyl transferase, family 2
AL474_02250	COG0438	transferase activity, transferring glycosyl groups
AL474_02255	COG2194	sulfuric ester hydrolase activity
AL474_02280	COG0859	PFAM glycosyl transferase family 9
AL474_02285	COG1132	(ABC) transporter
AL474_02305	COG1530	ribonuclease E activity
AL474_02345	COG3468	outer membrane autotransporter barrel domain protein
AL474_02350	COG0424	maF-like protein
AL474_02355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL474_02360	COG0799	negative regulation of ribosome biogenesis
AL474_02365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL474_02370	COG0408	coproporphyrinogen oxidase activity
AL474_02375	COG0151	Belongs to the GarS family
AL474_02380	COG0217	transcriptional regulatory protein
AL474_02385	COG0433	COG0433 Predicted ATPase
AL474_02390	COG1115	amino acid carrier protein
AL474_02395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL474_02405	COG1012	belongs to the aldehyde dehydrogenase family
AL474_02430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL474_02445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_02455	COG0747	negative chemotaxis
AL474_02465	COG0473	3-isopropylmalate dehydrogenase activity
AL474_02470	COG2814	Major facilitator Superfamily
AL474_02475	COG1566	PFAM secretion protein HlyD family protein
AL474_02485	COG1846	Transcriptional regulator
AL474_02495	COG0697	spore germination
AL474_02505	COG0501	Belongs to the peptidase M48B family
AL474_02525	COG0583	DNA-binding transcription factor activity
AL474_02530	COG3842	ATPase activity
AL474_02535	COG1178	ABC-type Fe3 transport system permease component
AL474_02540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL474_02545	COG1840	ABC-type Fe3 transport system, periplasmic component
AL474_02570	COG2233	PERMEase
AL474_02575	COG0840	transmembrane signaling receptor activity
AL474_02580	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL474_02610	COG4789	Type iii secretion
AL474_02675	COG4669	(LipO)protein
AL474_02705	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AL474_02710	COG4790	Type iii secretion
AL474_02715	COG4794	Type iii secretion
AL474_02720	COG4791	protein targeting
AL474_02725	COG4792	protein secretion
AL474_02740	COG1595	DNA-templated transcription, initiation
AL474_02760	COG2770	Histidine kinase
AL474_02760	COG2208	phosphoserine phosphatase activity
AL474_02770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL474_02775	COG2172	sigma factor antagonist activity
AL474_02780	COG1366	Belongs to the anti-sigma-factor antagonist family
AL474_02785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL474_02820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL474_02850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL474_02860	COG2252	PERMEase
AL474_02865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL474_02875	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL474_02880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AL474_02885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL474_02910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL474_02915	COG0789	Transcriptional regulator
AL474_02925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL474_02925	COG0678	peroxiredoxin activity
AL474_02935	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AL474_02940	COG0584	glycerophosphoryl diester phosphodiesterase
AL474_02945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL474_02955	COG4181	ATPase activity
AL474_02970	COG2823	Periplasmic or secreted lipoprotein
AL474_02980	COG3237	CsbD-like
AL474_03010	COG2833	Protein of unknown function (DUF455)
AL474_03015	COG2951	lytic endotransglycosylase activity
AL474_03030	COG1522	sequence-specific DNA binding
AL474_03040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL474_03045	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL474_03050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL474_03055	COG0196	riboflavin kinase activity
AL474_03060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AL474_03080	COG0210	DNA helicase
AL474_03085	COG4771	TonB-dependent receptor
AL474_03090	COG0488	(ABC) transporter
AL474_03095	COG2890	protein-(glutamine-N5) methyltransferase activity
AL474_03100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL474_03105	COG2171	N-acyltransferase activity
AL474_03140	COG1278	Cold shock
AL474_03150	COG1278	Cold shock
AL474_03160	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL474_03165	COG0740	serine-type endopeptidase activity
AL474_03170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL474_03175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AL474_03180	COG0583	DNA-binding transcription factor activity
AL474_03185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_03200	COG1024	Enoyl-CoA hydratase
AL474_03210	COG0183	Belongs to the thiolase family
AL474_03215	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_03235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AL474_03265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL474_03275	COG0556	nucleotide-excision repair
AL474_03280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL474_03290	COG1104	cysteine desulfurase activity
AL474_03295	COG0822	iron-sulfur transferase activity
AL474_03300	COG0316	Belongs to the HesB IscA family
AL474_03305	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AL474_03310	COG0443	Heat shock 70 kDa protein
AL474_03315	COG0633	Ferredoxin
AL474_03335	COG1024	Enoyl-CoA hydratase
AL474_03350	COG3395	kinase activity
AL474_03370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AL474_03380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_03405	COG0747	negative chemotaxis
AL474_03410	COG0601	transmembrane transport
AL474_03415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_03420	COG4172	Belongs to the ABC transporter superfamily
AL474_03425	COG0154	amidase activity
AL474_03470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL474_03475	COG0425	Belongs to the sulfur carrier protein TusA family
AL474_03485	COG0228	four-way junction DNA binding
AL474_03490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL474_03495	COG0336	Belongs to the RNA methyltransferase TrmD family
AL474_03500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL474_03520	COG0642	Histidine kinase
AL474_03535	COG0525	valine-tRNA ligase activity
AL474_03540	COG0105	UTP biosynthetic process
AL474_03545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL474_03555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AL474_03560	COG0124	histidyl-tRNA synthetase
AL474_03565	COG2976	Protein conserved in bacteria
AL474_03570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL474_03575	COG1160	GTP binding
AL474_03580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL474_03585	COG1923	regulation of RNA biosynthetic process
AL474_03590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL474_03595	COG0330	HflC and HflK could
AL474_03600	COG0330	HflC and HflK could
AL474_03605	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AL474_03610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL474_03620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL474_03630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL474_03660	COG0628	permease
AL474_03665	COG0842	Transport permease protein
AL474_03670	COG1131	(ABC) transporter
AL474_03750	COG4106	trans-aconitate 2-methyltransferase activity
AL474_03750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AL474_03755	COG1380	Effector of murein hydrolase LrgA
AL474_03770	COG3284	Transcriptional regulator
AL474_03775	COG1012	belongs to the aldehyde dehydrogenase family
AL474_03790	COG2733	membrane
AL474_03795	COG0583	DNA-binding transcription factor activity
AL474_03800	COG0384	phenazine biosynthesis protein PhzF
AL474_03805	COG5507	3-demethylubiquinone-9 3-methyltransferase
AL474_03810	COG2169	Transcriptional regulator
AL474_03840	COG0659	secondary active sulfate transmembrane transporter activity
AL474_03865	COG1132	(ABC) transporter
AL474_03910	COG2207	Transcriptional regulator
AL474_04040	COG2346	COG2346, Truncated hemoglobins
AL474_04065	COG0583	DNA-binding transcription factor activity
AL474_04080	COG0183	Belongs to the thiolase family
AL474_04095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_04100	COG0633	Ferredoxin
AL474_04110	COG1024	Enoyl-CoA hydratase
AL474_04115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AL474_04120	COG4638	Rieske (2fe-2S)
AL474_04130	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_04150	COG2224	Isocitrate lyase
AL474_04155	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL474_04155	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL474_04170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AL474_04175	COG0322	excinuclease ABC activity
AL474_04180	COG1472	Belongs to the glycosyl hydrolase 3 family
AL474_04185	COG0736	holo-[acyl-carrier-protein] synthase activity
AL474_04190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AL474_04200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL474_04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL474_04230	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AL474_04245	COG2032	superoxide dismutase activity
AL474_04260	COG1024	Enoyl-CoA hydratase
AL474_04270	COG1802	Transcriptional regulator
AL474_04280	COG0183	Belongs to the thiolase family
AL474_04285	COG1942	4-Oxalocrotonate Tautomerase
AL474_04295	COG4176	ABC-type proline glycine betaine transport system permease component
AL474_04315	COG2814	Major facilitator Superfamily
AL474_04320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL474_04325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL474_04350	COG1846	Transcriptional regulator
AL474_04355	COG2814	Major facilitator Superfamily
AL474_04360	COG0495	leucyl-tRNA aminoacylation
AL474_04375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AL474_04385	COG0154	amidase activity
AL474_04390	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL474_04445	COG0427	acetyl-CoA hydrolase
AL474_04450	COG0583	DNA-binding transcription factor activity
AL474_04465	COG0730	response to heat
AL474_04470	COG0697	spore germination
AL474_04505	COG2885	chlorophyll binding
AL474_04530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL474_04535	COG3384	dioxygenase
AL474_04550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL474_04555	COG3474	cytochrome
AL474_04565	COG1595	DNA-templated transcription, initiation
AL474_04580	COG2204	response regulator
AL474_04615	COG4964	Belongs to the GSP D family
AL474_04665	COG1846	Transcriptional regulator
AL474_04670	COG4172	Belongs to the ABC transporter superfamily
AL474_04675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_04680	COG0601	transmembrane transport
AL474_04685	COG0747	negative chemotaxis
AL474_04695	COG0598	Magnesium transport protein CorA
AL474_04700	COG0210	DNA helicase
AL474_04715	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL474_04720	COG1012	belongs to the aldehyde dehydrogenase family
AL474_04725	COG0483	inositol monophosphate 1-phosphatase activity
AL474_04730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AL474_04740	COG1045	serine acetyltransferase
AL474_04760	COG2197	response regulator
AL474_04765	COG1846	Transcriptional regulator
AL474_04785	COG0726	polysaccharide deacetylase
AL474_04785	COG1649	PFAM Uncharacterised BCR, COG1649
AL474_04790	COG1215	transferase activity, transferring glycosyl groups
AL474_04800	COG1902	pentaerythritol trinitrate reductase activity
AL474_04825	COG0251	oxidation-reduction process
AL474_04835	COG1832	CoA-binding protein
AL474_04840	COG1414	Transcriptional regulator
AL474_04845	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL474_04845	COG1902	pentaerythritol trinitrate reductase activity
AL474_04855	COG3842	ATPase activity
AL474_04865	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL474_04885	COG0583	DNA-binding transcription factor activity
AL474_04895	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_04900	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AL474_04920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL474_04925	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL474_04950	COG0527	aspartate kinase activity
AL474_04955	COG0037	tRNA processing
AL474_04965	COG0825	malonyl-CoA metabolic process
AL474_04975	COG0215	cysteine-tRNA ligase activity
AL474_04990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AL474_04995	COG1968	undecaprenyl-diphosphatase activity
AL474_05000	COG1253	flavin adenine dinucleotide binding
AL474_05025	COG0668	transmembrane transport
AL474_05075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL474_05090	COG2831	hemolysin activation secretion protein
AL474_05095	COG3539	Fimbrial protein
AL474_05100	COG3188	usher protein
AL474_05105	COG3121	Chaperone
AL474_05110	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AL474_05110	COG3210	domain, Protein
AL474_05110	COG3064	Membrane
AL474_05115	COG2197	response regulator
AL474_05120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_05120	COG2205	protein histidine kinase activity
AL474_05130	COG4336	lyase activity
AL474_05165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL474_05185	COG0028	Belongs to the TPP enzyme family
AL474_05200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL474_05210	COG1126	abc transporter atp-binding protein
AL474_05220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_05235	COG0084	hydrolase, TatD family'
AL474_05240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL474_05245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL474_05250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AL474_05270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_05275	COG1959	2 iron, 2 sulfur cluster binding
AL474_05280	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL474_05280	COG1017	nitric oxide dioxygenase activity
AL474_05315	COG0488	(ABC) transporter
AL474_05320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL474_05335	COG1024	Enoyl-CoA hydratase
AL474_05340	COG1619	proteins homologs of microcin C7 resistance protein MccF
AL474_05345	COG0590	tRNA wobble adenosine to inosine editing
AL474_05370	COG2212	antiporter activity
AL474_05375	COG1863	multisubunit Na H antiporter MnhE subunit
AL474_05380	COG0651	ATP synthesis coupled electron transport
AL474_05385	COG1006	Multisubunit Na H antiporter MnhC subunit
AL474_05390	COG2111	Na H antiporter
AL474_05390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL474_05410	COG0583	DNA-binding transcription factor activity
AL474_05415	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_05445	COG0431	NADPH-dependent FMN reductase
AL474_05490	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_05495	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL474_05525	COG0625	glutathione transferase activity
AL474_05535	COG2944	sequence-specific DNA binding
AL474_05545	COG2197	response regulator
AL474_05570	COG3119	arylsulfatase activity
AL474_05600	COG0714	Associated with various cellular activities
AL474_05620	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_05625	COG0861	Integral membrane protein TerC family
AL474_05670	COG0300	oxidoreductase activity
AL474_05695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL474_05710	COG0438	transferase activity, transferring glycosyl groups
AL474_05745	COG0783	Belongs to the Dps family
AL474_05760	COG0583	DNA-binding transcription factor activity
AL474_05765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL474_05780	COG0656	L-ascorbic acid biosynthetic process
AL474_05790	COG0583	DNA-binding transcription factor activity
AL474_05800	COG1840	ABC-type Fe3 transport system, periplasmic component
AL474_05805	COG1178	ABC-type Fe3 transport system permease component
AL474_05810	COG3842	ATPase activity
AL474_05820	COG1741	Belongs to the pirin family
AL474_05825	COG1741	Belongs to the pirin family
AL474_05830	COG0583	DNA-binding transcription factor activity
AL474_05835	COG2204	response regulator
AL474_05840	COG3852	Histidine kinase
AL474_05850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL474_05860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AL474_05865	COG2200	EAL domain
AL474_05865	COG2199	diguanylate cyclase activity
AL474_05890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AL474_05895	COG1561	YicC-like family, N-terminal region
AL474_05915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL474_05920	COG0791	NLP P60 protein
AL474_05925	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_05935	COG3258	Cytochrome c
AL474_05940	COG0194	GDP metabolic process
AL474_05945	COG1758	RNA polymerase activity
AL474_05950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL474_05955	COG1126	abc transporter atp-binding protein
AL474_05960	COG0765	amino acid transport
AL474_05965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_05980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL474_05985	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AL474_05990	COG3539	Fimbrial protein
AL474_05995	COG2850	peptidyl-arginine hydroxylation
AL474_06000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL474_06005	COG3360	Dodecin
AL474_06045	COG0009	L-threonylcarbamoyladenylate synthase
AL474_06050	COG2321	neutral zinc metallopeptidase
AL474_06070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL474_06075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL474_06110	COG1686	Belongs to the peptidase S11 family
AL474_06125	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AL474_06130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL474_06135	COG4974	Belongs to the 'phage' integrase family
AL474_06140	COG0583	DNA-binding transcription factor activity
AL474_06145	COG0028	Belongs to the TPP enzyme family
AL474_06160	COG0028	Belongs to the TPP enzyme family
AL474_06165	COG1126	abc transporter atp-binding protein
AL474_06170	COG0765	amino acid transport
AL474_06185	COG1414	Transcriptional regulator
AL474_06190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_06195	COG0009	L-threonylcarbamoyladenylate synthase
AL474_06200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL474_06205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL474_06210	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AL474_06220	COG2944	sequence-specific DNA binding
AL474_06230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL474_06285	COG1126	abc transporter atp-binding protein
AL474_06290	COG0765	amino acid transport
AL474_06295	COG0765	amino acid transport
AL474_06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_06310	COG2423	ornithine cyclodeaminase activity
AL474_06325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL474_06330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL474_06340	COG0189	ligase activity
AL474_06345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL474_06350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL474_06355	COG2197	response regulator
AL474_06375	COG3706	GGDEF domain
AL474_06395	COG3022	response to hydroperoxide
AL474_06405	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_06450	COG2814	Major facilitator Superfamily
AL474_06470	COG3706	GGDEF domain
AL474_06495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL474_06500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL474_06505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AL474_06510	COG1674	ftsk spoiiie
AL474_06515	COG0492	ferredoxin-NADP+ reductase activity
AL474_06535	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL474_06545	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AL474_06550	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AL474_06555	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AL474_06565	COG0745	RESPONSE REGULATOR receiver
AL474_06610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL474_06630	COG0612	Peptidase, M16
AL474_06640	COG0443	Heat shock 70 kDa protein
AL474_06650	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL474_06660	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL474_06665	COG1420	regulation of RNA biosynthetic process
AL474_06670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL474_06675	COG0497	DNA recombination
AL474_06680	COG0735	belongs to the Fur family
AL474_06685	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AL474_06690	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL474_06695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL474_06730	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL474_06730	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL474_06735	COG4311	Sarcosine oxidase, delta subunit
AL474_06740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_06750	COG0583	DNA-binding transcription factor activity
AL474_06760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL474_06785	COG4964	Belongs to the GSP D family
AL474_06825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AL474_06845	COG0181	hydroxymethylbilane synthase activity
AL474_06850	COG0861	Integral membrane protein TerC family
AL474_06855	COG0861	Integral membrane protein TerC family
AL474_06860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AL474_06865	COG0045	succinate-CoA ligase (ADP-forming) activity
AL474_06875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL474_06880	COG0583	DNA-binding transcription factor activity
AL474_06885	COG2137	regulation of response to DNA damage stimulus
AL474_06890	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL474_06900	COG0642	Histidine kinase
AL474_06910	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL474_06910	COG1024	Enoyl-CoA hydratase
AL474_06915	COG3842	ATPase activity
AL474_06930	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_06950	COG0583	DNA-binding transcription factor activity
AL474_06955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_06965	COG2974	May be involved in recombination
AL474_06970	COG0540	Belongs to the ATCase OTCase family
AL474_07035	COG0776	regulation of translation
AL474_07040	COG0072	phenylalanine-tRNA ligase activity
AL474_07040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL474_07045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL474_07050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL474_07055	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL474_07065	COG0756	dUTP diphosphatase activity
AL474_07075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL474_07090	COG0500	methyltransferase
AL474_07105	COG0586	Pfam SNARE associated Golgi protein
AL474_07135	COG1609	Transcriptional regulator
AL474_07140	COG4172	Belongs to the ABC transporter superfamily
AL474_07150	COG0601	transmembrane transport
AL474_07155	COG0747	negative chemotaxis
AL474_07175	COG1280	lysine exporter protein (LysE YggA)
AL474_07190	COG2814	Major facilitator Superfamily
AL474_07220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AL474_07235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AL474_07270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_07275	COG1116	anion transmembrane transporter activity
AL474_07285	COG1228	amidohydrolase
AL474_07300	COG0477	Major facilitator Superfamily
AL474_07310	COG3550	peptidyl-serine autophosphorylation
AL474_07320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL474_07320	COG0519	Catalyzes the synthesis of GMP from XMP
AL474_07370	COG0420	3'-5' exonuclease activity
AL474_07375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_07405	COG0395	ABC-type sugar transport system, permease component
AL474_07450	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_07455	COG1053	succinate dehydrogenase
AL474_07485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL474_07510	COG0602	queuosine metabolic process
AL474_07515	COG0720	synthase
AL474_07520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL474_07525	COG0235	Class ii aldolase
AL474_07555	COG0047	phosphoribosylformylglycinamidine synthase activity
AL474_07555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL474_07560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AL474_07565	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AL474_07570	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL474_07585	COG3539	Fimbrial protein
AL474_07595	COG2050	protein possibly involved in aromatic compounds catabolism
AL474_07600	COG1024	Enoyl-CoA hydratase
AL474_07605	COG1012	belongs to the aldehyde dehydrogenase family
AL474_07620	COG2151	metal-sulfur cluster biosynthetic enzyme
AL474_07625	COG3396	Phenylacetate-CoA oxygenase
AL474_07630	COG3460	Phenylacetate-CoA oxygenase
AL474_07635	COG3396	Phenylacetate-CoA oxygenase
AL474_07640	COG3327	negative regulation of DNA-templated transcription, initiation
AL474_07650	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AL474_07655	COG0501	Belongs to the peptidase M48B family
AL474_07660	COG1162	GTPase activity
AL474_07670	COG0601	transmembrane transport
AL474_07675	COG0747	negative chemotaxis
AL474_07720	COG0668	transmembrane transport
AL474_07725	COG0165	Argininosuccinate lyase
AL474_07745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL474_07750	COG0303	'Molybdopterin
AL474_07755	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL474_07770	COG0315	cyclic pyranopterin monophosphate synthase activity
AL474_07780	COG0412	Dienelactone hydrolase
AL474_07790	COG0678	peroxiredoxin activity
AL474_07800	COG0697	spore germination
AL474_07805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AL474_07830	COG0789	Transcriptional regulator
AL474_07850	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_07860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL474_07865	COG1845	cytochrome c oxidase, subunit III
AL474_07870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL474_07880	COG0477	Major facilitator Superfamily
AL474_07920	COG1309	transcriptional regulator
AL474_07925	COG2271	Major facilitator Superfamily
AL474_07945	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_07960	COG0506	proline dehydrogenase activity
AL474_07960	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AL474_07960	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AL474_07970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL474_07970	COG3008	intermembrane lipid transfer
AL474_07975	COG2995	paraquat-inducible protein a
AL474_07980	COG0542	response to heat
AL474_07995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AL474_08000	COG1278	Cold shock
AL474_08010	COG0183	Belongs to the thiolase family
AL474_08015	COG0038	chloride channel
AL474_08020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL474_08035	COG0811	peptide transport
AL474_08040	COG0848	biopolymer transport protein
AL474_08050	COG2835	tetraacyldisaccharide 4'-kinase activity
AL474_08055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AL474_08060	COG0563	adenylate kinase activity
AL474_08080	COG0268	Binds directly to 16S ribosomal RNA
AL474_08110	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AL474_08135	COG0436	Aminotransferase
AL474_08140	COG3737	Protein of unknown function (DUF498/DUF598)
AL474_08145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL474_08155	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AL474_08165	COG0305	Participates in initiation and elongation during chromosome replication
AL474_08175	COG0359	binds to the 23S rRNA
AL474_08180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL474_08185	COG2965	DNA replication, synthesis of RNA primer
AL474_08190	COG0360	Binds together with S18 to 16S ribosomal RNA
AL474_08195	COG1469	GTP cyclohydrolase I activity
AL474_08200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AL474_08205	COG0142	geranyltranstransferase activity
AL474_08210	COG1722	exodeoxyribonuclease VII activity
AL474_08220	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_08245	COG2239	Acts as a magnesium transporter
AL474_08250	COG1607	acyl-coa hydrolase
AL474_08255	COG2855	membrane
AL474_08265	COG1473	amidohydrolase
AL474_08270	COG0318	PFAM AMP-dependent synthetase and ligase
AL474_08290	COG1501	Belongs to the glycosyl hydrolase 31 family
AL474_08295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL474_08300	COG2011	ABC-type metal ion transport system permease component
AL474_08320	COG1454	alcohol dehydrogenase
AL474_08345	COG2186	Transcriptional regulator
AL474_08350	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_08370	COG1175	transmembrane transport
AL474_08375	COG0395	ABC-type sugar transport system, permease component
AL474_08380	COG3842	ATPase activity
AL474_08395	COG1653	transport
AL474_08415	COG2818	Glycosylase
AL474_08420	COG2982	Protein involved in outer membrane biogenesis
AL474_08430	COG1309	transcriptional regulator
AL474_08435	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_08475	COG0583	DNA-binding transcription factor activity
AL474_08480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL474_08485	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL474_08500	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_08505	COG0477	Major facilitator Superfamily
AL474_08515	COG0583	DNA-binding transcription factor activity
AL474_08520	COG1448	Aminotransferase
AL474_08525	COG1418	mRNA catabolic process
AL474_08550	COG1063	alcohol dehydrogenase
AL474_08570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_08580	COG0318	PFAM AMP-dependent synthetase and ligase
AL474_08590	COG1522	sequence-specific DNA binding
AL474_08595	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_08600	COG0307	riboflavin synthase, alpha
AL474_08605	COG0154	amidase activity
AL474_08625	COG2807	transmembrane transport
AL474_08630	COG0590	tRNA wobble adenosine to inosine editing
AL474_08640	COG0583	DNA-binding transcription factor activity
AL474_08660	COG0410	ABC transporter
AL474_08675	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_08680	COG0251	oxidation-reduction process
AL474_08685	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL474_08695	COG1414	Transcriptional regulator
AL474_08715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_08735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_08740	COG0154	amidase activity
AL474_08780	COG3909	cytochrome
AL474_08785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL474_08790	COG0625	glutathione transferase activity
AL474_08795	COG0730	response to heat
AL474_08800	COG0482	sulfurtransferase activity
AL474_08805	COG0583	DNA-binding transcription factor activity
AL474_08820	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AL474_08825	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AL474_08840	COG2819	hydrolase of the alpha beta superfamily
AL474_08845	COG0247	lactate metabolic process
AL474_08850	COG0277	FAD linked oxidase domain protein
AL474_08855	COG0277	FAD linked oxidase domain protein
AL474_08860	COG0277	FAD linked oxidase domain protein
AL474_08865	COG3064	Membrane
AL474_08865	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AL474_08865	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
AL474_08865	COG3210	domain, Protein
AL474_08865	COG3064	Membrane
AL474_08865	COG3210	domain, Protein
AL474_08870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AL474_08875	COG0312	modulator of DNA gyrase
AL474_08880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL474_08955	COG3220	belongs to the UPF0276 family
AL474_08975	COG0640	Transcriptional regulator
AL474_08980	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL474_08985	COG1845	cytochrome c oxidase, subunit III
AL474_08990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL474_09000	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AL474_09040	COG0583	DNA-binding transcription factor activity
AL474_09070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL474_09070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL474_09085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL474_09090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL474_09100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL474_09115	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AL474_09120	COG0316	Belongs to the HesB IscA family
AL474_09130	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL474_09135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL474_09140	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL474_09145	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL474_09150	COG0312	modulator of DNA gyrase
AL474_09155	COG3028	Belongs to the UPF0307 family
AL474_09170	COG1116	anion transmembrane transporter activity
AL474_09175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_09180	COG1335	isochorismatase
AL474_09185	COG0346	lactoylglutathione lyase activity
AL474_09190	COG0513	Belongs to the DEAD box helicase family
AL474_09195	COG3069	C4-dicarboxylate transmembrane transporter activity
AL474_09200	COG1802	Transcriptional regulator
AL474_09210	COG0045	succinate-CoA ligase (ADP-forming) activity
AL474_09210	COG1042	CoA-binding domain protein
AL474_09210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL474_09215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL474_09230	COG1522	sequence-specific DNA binding
AL474_09265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL474_09270	COG1696	Membrane protein involved in D-alanine export
AL474_09310	COG0439	Biotin carboxylase
AL474_09315	COG0511	ligase activity, forming carbon-carbon bonds
AL474_09320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AL474_09325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL474_09330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL474_09335	COG3150	esterase
AL474_09340	COG0557	exoribonuclease II activity
AL474_09350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL474_09370	COG1522	sequence-specific DNA binding
AL474_09375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_09380	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_09400	COG0653	protein targeting
AL474_09405	COG0739	heme binding
AL474_09415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AL474_09420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL474_09430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL474_09435	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL474_09440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL474_09445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL474_09455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL474_09460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL474_09465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL474_09475	COG3116	cell division
AL474_09480	COG0275	rRNA processing
AL474_09485	COG2001	Belongs to the MraZ family
AL474_09500	COG0418	dihydroorotase activity
AL474_09505	COG1473	amidohydrolase
AL474_09545	COG1522	sequence-specific DNA binding
AL474_09555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL474_09560	COG4654	Cytochrome c, class I
AL474_09565	COG0129	dihydroxy-acid dehydratase activity
AL474_09570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL474_09620	COG2084	Dehydrogenase
AL474_09640	COG2096	Adenosyltransferase
AL474_09650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL474_09655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL474_09660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AL474_09665	COG0523	cobalamin synthesis protein
AL474_09670	COG0735	belongs to the Fur family
AL474_09680	COG1121	(ABC) transporter
AL474_09690	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL474_09700	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
AL474_09720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AL474_09725	COG1560	Kdo2-lipid A biosynthetic process
AL474_09735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL474_09750	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AL474_09755	COG1950	PFAM Membrane protein of
AL474_09770	COG0583	DNA-binding transcription factor activity
AL474_09780	COG0477	Major facilitator Superfamily
AL474_09805	COG0513	Belongs to the DEAD box helicase family
AL474_09810	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL474_09820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL474_09825	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AL474_09900	COG0405	Gamma-glutamyltransferase
AL474_09910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_09935	COG1309	transcriptional regulator
AL474_09950	COG0745	RESPONSE REGULATOR receiver
AL474_09995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL474_10015	COG0582	viral genome integration into host DNA
AL474_10020	COG0012	GTP binding
AL474_10030	COG0193	aminoacyl-tRNA hydrolase activity
AL474_10035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL474_10040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL474_10050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL474_10055	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AL474_10065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL474_10090	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AL474_10100	COG1368	sulfuric ester hydrolase activity
AL474_10105	COG0642	Histidine kinase
AL474_10110	COG0745	RESPONSE REGULATOR receiver
AL474_10115	COG0277	FAD linked oxidase domain protein
AL474_10130	COG0166	Belongs to the GPI family
AL474_10135	COG0438	transferase activity, transferring glycosyl groups
AL474_10155	COG0438	transferase activity, transferring glycosyl groups
AL474_10170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AL474_10175	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL474_10180	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AL474_10190	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL474_10200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL474_10215	COG0747	negative chemotaxis
AL474_10220	COG0601	transmembrane transport
AL474_10225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_10245	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AL474_10250	COG0830	nickel cation binding
AL474_10260	COG0804	urea catabolic process
AL474_10265	COG0832	Belongs to the urease beta subunit family
AL474_10275	COG0831	urea catabolic process
AL474_10280	COG0829	nickel cation binding
AL474_10305	COG2188	Transcriptional regulator
AL474_10330	COG2719	SpoVR family
AL474_10335	COG2718	Belongs to the UPF0229 family
AL474_10355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_10370	COG1960	acyl-CoA dehydrogenase activity
AL474_10390	COG0411	ABC transporter
AL474_10465	COG0328	RNA-DNA hybrid ribonuclease activity
AL474_10470	COG2226	methyltransferase
AL474_10480	COG0741	lytic transglycosylase activity
AL474_10480	COG1388	LysM domain
AL474_10500	COG2979	Protein of unknown function (DUF533)
AL474_10520	COG0745	RESPONSE REGULATOR receiver
AL474_10535	COG1271	oxidase subunit
AL474_10540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL474_10545	COG0850	regulation of cytokinetic process
AL474_10550	COG2894	cell division
AL474_10555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AL474_10585	COG0601	transmembrane transport
AL474_10595	COG1215	transferase activity, transferring glycosyl groups
AL474_10610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AL474_10620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL474_10640	COG0318	PFAM AMP-dependent synthetase and ligase
AL474_10645	COG2188	Transcriptional regulator
AL474_10650	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL474_10655	COG2814	Major facilitator Superfamily
AL474_10665	COG0259	pyridoxamine-phosphate oxidase activity
AL474_10670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL474_10685	COG0583	DNA-binding transcription factor activity
AL474_10720	COG0134	indole-3-glycerol-phosphate synthase activity
AL474_10725	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL474_10730	COG0512	Glutamine amidotransferase of anthranilate synthase
AL474_10740	COG0546	phosphoglycolate phosphatase activity
AL474_10750	COG2967	ApaG domain
AL474_10755	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
AL474_10760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AL474_10765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL474_10770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL474_10780	COG0037	tRNA processing
AL474_10790	COG3634	alkyl hydroperoxide reductase activity
AL474_10795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL474_10800	COG1024	Enoyl-CoA hydratase
AL474_10825	COG0356	it plays a direct role in the translocation of protons across the membrane
AL474_10835	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL474_10840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL474_10845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL474_10850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL474_10855	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL474_10860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL474_10870	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL474_10875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL474_10880	COG0210	DNA helicase
AL474_10890	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL474_10905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_10910	COG0601	transmembrane transport
AL474_10930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL474_10935	COG1024	Enoyl-CoA hydratase
AL474_10940	COG1024	Enoyl-CoA hydratase
AL474_11000	COG2132	Multicopper oxidase
AL474_11010	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL474_11010	COG1024	Enoyl-CoA hydratase
AL474_11025	COG1414	Transcriptional regulator
AL474_11035	COG0154	amidase activity
AL474_11065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL474_11070	COG3568	Endonuclease Exonuclease Phosphatase
AL474_11075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL474_11115	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AL474_11125	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AL474_11140	COG1137	ATPase activity
AL474_11155	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AL474_11160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AL474_11160	COG2010	Cytochrome c
AL474_11175	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AL474_11215	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_11225	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AL474_11230	COG2890	protein-(glutamine-N5) methyltransferase activity
AL474_11235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL474_11240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL474_11285	COG1960	acyl-CoA dehydrogenase activity
AL474_11295	COG0183	Belongs to the thiolase family
AL474_11300	COG1522	sequence-specific DNA binding
AL474_11305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL474_11325	COG1024	Enoyl-CoA hydratase
AL474_11340	COG0604	alcohol dehydrogenase
AL474_11360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL474_11370	COG1960	acyl-CoA dehydrogenase activity
AL474_11375	COG1960	acyl-CoA dehydrogenase activity
AL474_11380	COG0277	FAD linked oxidase domain protein
AL474_11390	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_11410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL474_11420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_11425	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_11430	COG1960	acyl-CoA dehydrogenase activity
AL474_11450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL474_11455	COG1024	Enoyl-CoA hydratase
AL474_11460	COG1960	acyl-CoA dehydrogenase activity
AL474_11480	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL474_11485	COG0022	dehydrogenase e1 component
AL474_11490	COG1024	Enoyl-CoA hydratase
AL474_11495	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL474_11515	COG0683	leucine binding
AL474_11520	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_11525	COG0411	ABC transporter
AL474_11530	COG0410	ABC transporter
AL474_11535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL474_11550	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_11575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL474_11580	COG0793	Belongs to the peptidase S41A family
AL474_11585	COG4942	peptidase
AL474_11590	COG0588	phosphoglycerate mutase activity
AL474_11600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AL474_11605	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AL474_11610	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL474_11615	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_11630	COG2226	methyltransferase
AL474_11635	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AL474_11650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_11655	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AL474_11680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL474_11705	COG1335	isochorismatase
AL474_11710	COG2309	aminopeptidase activity
AL474_11720	COG3473	Maleate cis-trans isomerase
AL474_11750	COG0569	domain protein
AL474_11755	COG2204	response regulator
AL474_11760	COG5000	phosphorelay sensor kinase activity
AL474_11770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL474_11770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL474_11780	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
AL474_11805	COG0583	DNA-binding transcription factor activity
AL474_11825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL474_11830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_11850	COG1522	sequence-specific DNA binding
AL474_11860	COG0242	peptide deformylase activity
AL474_11870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL474_11880	COG0546	phosphoglycolate phosphatase activity
AL474_11905	COG1942	4-Oxalocrotonate Tautomerase
AL474_11910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_11930	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL474_11950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL474_11955	COG1024	Enoyl-CoA hydratase
AL474_11960	COG1414	Transcriptional regulator
AL474_11965	COG0318	PFAM AMP-dependent synthetase and ligase
AL474_11970	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_12020	COG0330	HflC and HflK could
AL474_12030	COG0251	oxidation-reduction process
AL474_12060	COG3723	Recombinational DNA repair protein, rece pathway
AL474_12095	COG0582	viral genome integration into host DNA
AL474_12130	COG0706	membrane insertase activity
AL474_12135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL474_12140	COG0594	ribonuclease P activity
AL474_12145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AL474_12165	COG1414	Transcriptional regulator
AL474_12170	COG0154	amidase activity
AL474_12185	COG1304	FMN binding
AL474_12235	COG0183	Belongs to the thiolase family
AL474_12240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AL474_12255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL474_12260	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_12280	COG1629	transport
AL474_12285	COG2922	Belongs to the Smg family
AL474_12310	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AL474_12315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_12320	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_12325	COG1012	belongs to the aldehyde dehydrogenase family
AL474_12335	COG0028	Belongs to the TPP enzyme family
AL474_12340	COG1522	sequence-specific DNA binding
AL474_12345	COG3781	membrane
AL474_12355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL474_12375	COG4206	TonB-dependent receptor
AL474_12380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL474_12385	COG2022	thiamine diphosphate biosynthetic process
AL474_12390	COG0351	phosphomethylpyrimidine kinase
AL474_12395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AL474_12410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL474_12420	COG0628	permease
AL474_12430	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AL474_12440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL474_12445	COG0049	tRNA binding
AL474_12450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL474_12455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL474_12460	COG0051	transcription antitermination factor activity, RNA binding
AL474_12465	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL474_12470	COG0088	Forms part of the polypeptide exit tunnel
AL474_12475	COG0089	rRNA binding
AL474_12480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL474_12485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL474_12490	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL474_12495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL474_12500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL474_12505	COG0255	Belongs to the universal ribosomal protein uL29 family
AL474_12510	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL474_12530	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL474_12535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL474_12540	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL474_12545	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL474_12550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL474_12555	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL474_12560	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL474_12565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL474_12570	COG1841	ribosomal large subunit assembly
AL474_12575	COG0200	Binds to the 23S rRNA
AL474_12580	COG0201	protein transport
AL474_12585	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL474_12590	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL474_12595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL474_12600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL474_12605	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL474_12610	COG0202	RNA polymerase activity
AL474_12615	COG0203	ribosomal protein L17
AL474_12625	COG1324	tolerance protein
AL474_12645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL474_12655	COG1333	cytochrome c biogenesis protein
AL474_12660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL474_12670	COG1965	Belongs to the frataxin family
AL474_12685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL474_12690	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AL474_12760	COG0438	transferase activity, transferring glycosyl groups
AL474_12780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_12805	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AL474_12830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL474_12835	COG1956	GAF domain-containing protein
AL474_12840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL474_12850	COG1652	LysM domain
AL474_12865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL474_12880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL474_12905	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_12920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_12935	COG1024	Enoyl-CoA hydratase
AL474_12950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_12955	COG1309	transcriptional regulator
AL474_12960	COG2816	NAD+ diphosphatase activity
AL474_12965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL474_13005	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_13050	COG2814	Major facilitator Superfamily
AL474_13055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL474_13075	COG1999	signal sequence binding
AL474_13080	COG0109	protoheme IX farnesyltransferase activity
AL474_13120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL474_13140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AL474_13145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL474_13155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AL474_13160	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AL474_13170	COG0070	glutamate synthase
AL474_13170	COG0069	glutamate synthase activity
AL474_13170	COG0067	glutamate synthase
AL474_13180	COG3047	cAMP biosynthetic process
AL474_13190	COG1127	ABC transporter
AL474_13195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL474_13200	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AL474_13205	COG2853	Lipoprotein
AL474_13220	COG0842	Transport permease protein
AL474_13230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL474_13235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL474_13240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL474_13245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL474_13250	COG0131	Imidazoleglycerol-phosphate dehydratase
AL474_13255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL474_13260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL474_13265	COG0107	imidazoleglycerol-phosphate synthase activity
AL474_13270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AL474_13280	COG0537	adenosine 5'-monophosphoramidase activity
AL474_13285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL474_13290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AL474_13305	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_13345	COG3451	type IV secretory pathway VirB4
AL474_13365	COG3504	Conjugal transfer protein
AL474_13370	COG2948	multi-organism process
AL474_13385	COG0697	spore germination
AL474_13405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL474_13410	COG0747	negative chemotaxis
AL474_13420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_13435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AL474_13445	COG0494	nUDIX hydrolase
AL474_13465	COG1538	Outer membrane efflux protein
AL474_13485	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AL474_13490	COG0237	dephospho-CoA kinase activity
AL474_13495	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AL474_13510	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL474_13515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AL474_13525	COG0477	Major facilitator Superfamily
AL474_13530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL474_13545	COG1126	abc transporter atp-binding protein
AL474_13550	COG0765	amino acid transport
AL474_13555	COG4597	amino acid ABC transporter
AL474_13560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_13565	COG2884	Cell division ATP-binding protein ftsE
AL474_13570	COG2177	Part of the ABC transporter FtsEX involved in
AL474_13575	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AL474_13585	COG1194	a g-specific adenine glycosylase
AL474_13595	COG2226	methyltransferase
AL474_13605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_13610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_13625	COG1024	Enoyl-CoA hydratase
AL474_13645	COG1024	Enoyl-CoA hydratase
AL474_13650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_13665	COG0753	catalase activity
AL474_13670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_13675	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AL474_13685	COG2175	clavaminate synthase activity
AL474_13690	COG1473	amidohydrolase
AL474_13695	COG4608	Belongs to the ABC transporter superfamily
AL474_13700	COG0444	Belongs to the ABC transporter superfamily
AL474_13710	COG0601	transmembrane transport
AL474_13715	COG0747	negative chemotaxis
AL474_13720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL474_13735	COG3850	Histidine kinase
AL474_13735	COG5002	protein histidine kinase activity
AL474_13755	COG0436	Aminotransferase
AL474_13765	COG0445	tRNA wobble uridine modification
AL474_13775	COG1192	Involved in chromosome partitioning
AL474_13785	COG1475	DNA binding
AL474_13815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL474_13825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL474_13835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL474_13840	COG0081	regulation of translation
AL474_13845	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL474_13850	COG0222	ribosome binding
AL474_13855	COG0085	RNA polymerase activity
AL474_13860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL474_13900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_13925	COG1024	Enoyl-CoA hydratase
AL474_13945	COG0752	glycyl-tRNA synthetase alpha subunit
AL474_13950	COG0751	glycine-tRNA ligase activity
AL474_13955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AL474_13960	COG0204	Acyl-transferase
AL474_13975	COG0242	peptide deformylase activity
AL474_14015	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL474_14020	COG2813	Specifically methylates the guanine in position
AL474_14020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL474_14030	COG2223	nitrite transmembrane transporter activity
AL474_14040	COG1794	racemase activity, acting on amino acids and derivatives
AL474_14045	COG1126	abc transporter atp-binding protein
AL474_14050	COG0765	amino acid transport
AL474_14055	COG0765	amino acid transport
AL474_14060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL474_14120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AL474_14150	COG0326	Molecular chaperone. Has ATPase activity
AL474_14155	COG0625	glutathione transferase activity
AL474_14170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL474_14175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL474_14205	COG0438	transferase activity, transferring glycosyl groups
AL474_14210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AL474_14215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AL474_14245	COG0859	PFAM glycosyl transferase family 9
AL474_14260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AL474_14270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AL474_14275	COG1127	ABC transporter
AL474_14300	COG1686	Belongs to the peptidase S11 family
AL474_14310	COG2921	Belongs to the UPF0250 family
AL474_14315	COG0321	lipoyl(octanoyl) transferase activity
AL474_14320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL474_14355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AL474_14365	COG0018	arginyl-trna synthetase
AL474_14385	COG0395	ABC-type sugar transport system, permease component
AL474_14390	COG1175	transmembrane transport
AL474_14395	COG1653	transport
AL474_14400	COG3842	ATPase activity
AL474_14405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AL474_14415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AL474_14440	COG0154	amidase activity
AL474_14445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL474_14455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AL474_14465	COG0583	DNA-binding transcription factor activity
AL474_14485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL474_14500	COG1802	Transcriptional regulator
AL474_14515	COG1024	Enoyl-CoA hydratase
AL474_14530	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_14550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL474_14560	COG0583	DNA-binding transcription factor activity
AL474_14565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL474_14575	COG5002	protein histidine kinase activity
AL474_14585	COG5002	protein histidine kinase activity
AL474_14590	COG0745	RESPONSE REGULATOR receiver
AL474_14595	COG2226	methyltransferase
AL474_14610	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AL474_14645	COG0513	Belongs to the DEAD box helicase family
AL474_14650	COG1280	lysine exporter protein (LysE YggA)
AL474_14655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL474_14695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL474_14695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL474_14705	COG0489	protein tyrosine kinase activity
AL474_14720	COG0717	Belongs to the dCTP deaminase family
AL474_14745	COG1982	Orn Lys Arg decarboxylase major
AL474_14750	COG2081	HI0933 family
AL474_14760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL474_14770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL474_14775	COG0509	glycine decarboxylation via glycine cleavage system
AL474_14780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL474_14780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL474_14820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL474_14835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AL474_14845	COG1414	Transcriptional regulator
AL474_14850	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_14855	COG2031	fatty acid transporter
AL474_14860	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL474_14875	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AL474_14880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL474_14890	COG4257	antibiotic catabolic process
AL474_14910	COG1012	belongs to the aldehyde dehydrogenase family
AL474_14915	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AL474_14945	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_14955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL474_14965	COG2188	Transcriptional regulator
AL474_14970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AL474_14995	COG0617	tRNA 3'-terminal CCA addition
AL474_15010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL474_15015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL474_15025	COG0586	Pfam SNARE associated Golgi protein
AL474_15030	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL474_15035	COG0802	atpase or kinase
AL474_15040	COG0114	fumarate hydratase activity
AL474_15050	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_15065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_15100	COG1294	oxidase, subunit
AL474_15110	COG4988	ABC transporter
AL474_15120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL474_15160	COG2969	positive regulation of protein catabolic process
AL474_15165	COG0625	glutathione transferase activity
AL474_15170	COG2857	Cytochrome c1
AL474_15175	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AL474_15180	COG0723	plastoquinol--plastocyanin reductase activity
AL474_15185	COG1970	mechanosensitive ion channel activity
AL474_15190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL474_15205	COG2808	Putative FMN-binding domain
AL474_15210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL474_15215	COG0747	negative chemotaxis
AL474_15220	COG0657	acetylesterase activity
AL474_15230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL474_15240	COG0129	dihydroxy-acid dehydratase activity
AL474_15245	COG2814	Major facilitator Superfamily
AL474_15250	COG0583	DNA-binding transcription factor activity
AL474_15260	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
AL474_15300	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_15310	COG0411	ABC transporter
AL474_15315	COG0410	ABC transporter
AL474_15330	COG1024	Enoyl-CoA hydratase
AL474_15335	COG1960	acyl-CoA dehydrogenase activity
AL474_15360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL474_15380	COG1678	Uncharacterized ACR, COG1678
AL474_15385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL474_15390	COG0540	Belongs to the ATCase OTCase family
AL474_15405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL474_15415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL474_15450	COG1234	tRNA 3'-trailer cleavage
AL474_15465	COG3064	Membrane
AL474_15480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL474_15500	COG1120	ATPase activity
AL474_15505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL474_15510	COG4558	Periplasmic binding protein
AL474_15515	COG3720	iron ion transport
AL474_15525	COG3712	iron ion homeostasis
AL474_15530	COG1595	DNA-templated transcription, initiation
AL474_15565	COG1802	Transcriptional regulator
AL474_15575	COG3069	C4-dicarboxylate transmembrane transporter activity
AL474_15585	COG1012	belongs to the aldehyde dehydrogenase family
AL474_15620	COG2860	membrane
AL474_15625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AL474_15630	COG0708	Exodeoxyribonuclease III
AL474_15635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL474_15640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL474_15645	COG0154	amidase activity
AL474_15650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL474_15655	COG1077	Cell shape determining protein MreB Mrl
AL474_15660	COG1792	Involved in formation and maintenance of cell shape
AL474_15675	COG0772	Belongs to the SEDS family
AL474_15680	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
AL474_15685	COG0471	metal ion transport
AL474_15690	COG1309	transcriptional regulator
AL474_15700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL474_15715	COG2823	Periplasmic or secreted lipoprotein
AL474_15720	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AL474_15735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL474_15755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_15765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_15790	COG0492	ferredoxin-NADP+ reductase activity
AL474_15800	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_15805	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL474_15805	COG1024	Enoyl-CoA hydratase
AL474_15810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_15815	COG0028	Belongs to the TPP enzyme family
AL474_15840	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_15850	COG0697	spore germination
AL474_15875	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AL474_15880	COG0463	Glycosyl transferase, family 2
AL474_15895	COG0786	glutamate:sodium symporter activity
AL474_15905	COG2031	fatty acid transporter
AL474_15920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL474_15935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL474_15950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL474_15960	COG1285	pathogenesis
AL474_15965	COG1253	flavin adenine dinucleotide binding
AL474_15970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_15975	COG1024	Enoyl-CoA hydratase
AL474_15980	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_15985	COG0583	DNA-binding transcription factor activity
AL474_15990	COG1960	acyl-CoA dehydrogenase activity
AL474_16000	COG0183	Belongs to the thiolase family
AL474_16020	COG0583	DNA-binding transcription factor activity
AL474_16025	COG1278	Cold shock
AL474_16035	COG1802	Transcriptional regulator
AL474_16040	COG1012	belongs to the aldehyde dehydrogenase family
AL474_16045	COG2031	fatty acid transporter
AL474_16050	COG1017	nitric oxide dioxygenase activity
AL474_16050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL474_16055	COG0251	oxidation-reduction process
AL474_16080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_16090	COG0583	DNA-binding transcription factor activity
AL474_16095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AL474_16105	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AL474_16110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL474_16115	COG0546	phosphoglycolate phosphatase activity
AL474_16125	COG1530	ribonuclease E activity
AL474_16150	COG0159	tryptophan synthase activity
AL474_16155	COG0133	tryptophan synthase activity
AL474_16165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AL474_16170	COG3228	Belongs to the MtfA family
AL474_16180	COG0251	oxidation-reduction process
AL474_16185	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL474_16190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AL474_16205	COG2878	Part of a membrane complex involved in electron transport
AL474_16210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL474_16215	COG0411	ABC transporter
AL474_16230	COG0559	Belongs to the binding-protein-dependent transport system permease family
AL474_16245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL474_16250	COG0411	ABC transporter
AL474_16265	COG1268	BioY protein
AL474_16270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL474_16275	COG1122	ATPase activity
AL474_16280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL474_16300	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL474_16310	COG1196	nuclear chromosome segregation
AL474_16315	COG0477	Major facilitator Superfamily
AL474_16320	COG1573	uracil-dna glycosylase
AL474_16325	COG1214	PFAM Peptidase M22, glycoprotease
AL474_16330	COG0745	RESPONSE REGULATOR receiver
AL474_16340	COG2205	protein histidine kinase activity
AL474_16345	COG0450	alkyl hydroperoxide reductase
AL474_16350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AL474_16370	COG2186	Transcriptional regulator
AL474_16390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL474_16400	COG0583	DNA-binding transcription factor activity
AL474_16410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL474_16415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AL474_16420	COG0137	argininosuccinate synthase activity
AL474_16425	COG3158	transport of potassium into the cell
AL474_16430	COG0642	Histidine kinase
AL474_16435	COG0745	RESPONSE REGULATOR receiver
AL474_16460	COG0776	regulation of translation
AL474_16465	COG3128	pkhd-type hydroxylase
AL474_16475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL474_16480	COG0557	exoribonuclease II activity
AL474_16500	COG2153	protein acetylation
AL474_16505	COG0679	Auxin Efflux Carrier
AL474_16510	COG2391	methyltransferase activity
AL474_16515	COG0069	glutamate synthase activity
AL474_16525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AL474_16535	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AL474_16575	COG3706	GGDEF domain
AL474_16605	COG0583	DNA-binding transcription factor activity
AL474_16615	COG1053	succinate dehydrogenase
AL474_16635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL474_16640	COG0459	protein refolding
AL474_16660	COG1252	NADH dehydrogenase
AL474_16665	COG0284	orotidine-5'-phosphate decarboxylase activity
AL474_16670	COG1058	Belongs to the CinA family
AL474_16670	COG1546	Belongs to the CinA family
AL474_16675	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AL474_16685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL474_16690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL474_16730	COG3639	organic phosphonate transmembrane transporter activity
AL474_16735	COG3639	organic phosphonate transmembrane transporter activity
AL474_16755	COG0742	ribosomal rna small subunit methyltransferase
AL474_16760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL474_16765	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AL474_16770	COG3135	benzoate transporter
AL474_16785	COG0640	Transcriptional regulator
AL474_16815	COG4172	Belongs to the ABC transporter superfamily
AL474_16820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_16825	COG0601	transmembrane transport
AL474_16835	COG0281	malic enzyme
AL474_16835	COG0280	phosphate acetyltransferase
AL474_16895	COG0583	DNA-binding transcription factor activity
AL474_16910	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AL474_16915	COG0167	dihydroorotate dehydrogenase activity
AL474_16935	COG1414	Transcriptional regulator
AL474_16940	COG1546	Belongs to the CinA family
AL474_16940	COG1058	Belongs to the CinA family
AL474_16960	COG0513	Belongs to the DEAD box helicase family
AL474_16990	COG0429	hydrolase of the alpha beta-hydrolase fold
AL474_16995	COG4783	chaperone-mediated protein folding
AL474_17010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL474_17035	COG0006	proline dipeptidase activity
AL474_17065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AL474_17070	COG0632	four-way junction helicase activity
AL474_17085	COG2255	four-way junction helicase activity
AL474_17090	COG0514	ATP-dependent DNA helicase (RecQ)
AL474_17105	COG0288	reversible hydration of carbon dioxide
AL474_17110	COG0154	amidase activity
AL474_17115	COG0683	leucine binding
AL474_17120	COG4211	Belongs to the binding-protein-dependent transport system permease family
AL474_17135	COG0410	ABC transporter
AL474_17150	COG1464	Belongs to the NlpA lipoprotein family
AL474_17290	COG1196	nuclear chromosome segregation
AL474_17355	COG2135	peptidase activity
AL474_17370	COG0494	nUDIX hydrolase
AL474_17375	COG0442	prolyl-tRNA aminoacylation
AL474_17380	COG0824	Thioesterase
AL474_17385	COG0811	peptide transport
AL474_17390	COG0848	biopolymer transport protein
AL474_17400	COG0823	Involved in the tonB-independent uptake of proteins
AL474_17415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL474_17420	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AL474_17450	COG0700	Nucleoside recognition
AL474_17455	COG0469	pyruvate kinase activity
AL474_17460	COG1929	Belongs to the glycerate kinase type-1 family
AL474_17465	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL474_17470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL474_17475	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AL474_17485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AL474_17495	COG2154	pterin-4-alpha-carbinolamine dehydratase
AL474_17520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AL474_17525	COG0154	amidase activity
AL474_17535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL474_17540	COG0601	transmembrane transport
AL474_17545	COG0747	negative chemotaxis
AL474_17565	COG0019	diaminopimelate decarboxylase activity
AL474_17585	COG2353	YceI-like domain
AL474_17590	COG4774	siderophore transport
AL474_17595	COG3712	iron ion homeostasis
AL474_17635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AL474_17640	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL474_17645	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL474_17650	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL474_17660	COG0142	geranyltranstransferase activity
AL474_17670	COG0583	DNA-binding transcription factor activity
AL474_17680	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AL474_17685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_17700	COG2994	toxin metabolic process
AL474_17715	COG2274	protein secretion by the type I secretion system
AL474_17720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL474_17725	COG1538	Outer membrane efflux protein
AL474_17745	COG0765	amino acid transport
AL474_17750	COG1126	abc transporter atp-binding protein
AL474_17770	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_17780	COG1802	Transcriptional regulator
AL474_17790	COG1802	Transcriptional regulator
AL474_17800	COG0318	PFAM AMP-dependent synthetase and ligase
AL474_17810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL474_17820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AL474_17830	COG0028	Belongs to the TPP enzyme family
AL474_17850	COG0308	aminopeptidase N
AL474_17855	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AL474_17870	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL474_17875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL474_17880	COG0560	Phosphoserine phosphatase
AL474_17885	COG0583	DNA-binding transcription factor activity
AL474_17890	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_17895	COG0028	Belongs to the TPP enzyme family
AL474_17910	COG4774	siderophore transport
AL474_17915	COG4774	siderophore transport
AL474_17925	COG1007	ATP synthesis coupled electron transport
AL474_17940	COG0713	ATP synthesis coupled electron transport
AL474_17950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL474_17955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AL474_17960	COG1034	ATP synthesis coupled electron transport
AL474_17970	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AL474_17975	COG0649	NAD binding
AL474_17980	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL474_17985	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL474_17990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AL474_17995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AL474_18020	COG0671	phosphoesterase, PA-phosphatase related
AL474_18030	COG1597	lipid kinase activity
AL474_18035	COG0583	DNA-binding transcription factor activity
AL474_18040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL474_18050	COG1733	regulation of RNA biosynthetic process
AL474_18055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AL474_18060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL474_18075	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AL474_18095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AL474_18115	COG3608	succinylglutamate desuccinylase aspartoacylase
AL474_18120	COG0626	cystathionine gamma-synthase activity
AL474_18125	COG0583	DNA-binding transcription factor activity
AL474_18165	COG3799	methylaspartate ammonia-lyase activity
AL474_18175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL474_18185	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL474_18190	COG0149	triose-phosphate isomerase activity
AL474_18210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL474_18230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL474_18240	COG1183	phosphatidylcholine synthase activity
AL474_18245	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL474_18250	COG0440	acetolactate synthase activity
AL474_18255	COG0028	Belongs to the TPP enzyme family
AL474_18270	COG5265	(ABC) transporter
AL474_18275	COG0500	methyltransferase
AL474_18310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AL474_18345	COG2188	Transcriptional regulator
AL474_18350	COG0439	Biotin carboxylase
AL474_18400	COG5265	(ABC) transporter
AL474_18410	COG0667	Aldo Keto reductase
AL474_18425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AL474_18460	COG0583	DNA-binding transcription factor activity
AL474_18485	COG2814	Major facilitator Superfamily
AL474_18495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AL474_18510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AL474_18520	COG0287	Prephenate dehydrogenase
AL474_18525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL474_18530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL474_18550	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AL474_18555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AL474_18560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL474_18580	COG2951	lytic endotransglycosylase activity
AL474_18585	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL474_18600	COG1960	acyl-CoA dehydrogenase activity
AL474_18605	COG0450	alkyl hydroperoxide reductase
AL474_18630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AL474_18665	COG0335	large ribosomal subunit rRNA binding
AL474_18680	COG0667	Aldo Keto reductase
AL474_18695	COG3161	chorismate lyase activity
AL474_18700	COG1187	pseudouridine synthase activity
AL474_18730	COG1999	signal sequence binding
AL474_18735	COG0339	signal peptide processing
AL474_18745	COG4566	intracellular signal transduction
AL474_18755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AL474_18765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL474_18770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AL474_18780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL474_18785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AL474_18790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL474_18795	COG0126	phosphoglycerate kinase activity
AL474_18800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AL474_18805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL474_18820	COG0625	glutathione transferase activity
AL474_18865	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL474_18875	COG0739	heme binding
AL474_18885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AL474_18895	COG1191	sigma factor activity
AL474_18925	COG0643	Histidine kinase
AL474_18925	COG2198	Histidine kinase
AL474_18930	COG0835	chemotaxis
AL474_18935	COG0840	transmembrane signaling receptor activity
AL474_18945	COG2201	protein-glutamate methylesterase activity
AL474_18950	COG0745	RESPONSE REGULATOR receiver
AL474_18955	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AL474_18980	COG0667	Aldo Keto reductase
AL474_18990	COG4535	Mg2 and Co2 transporter CorC
AL474_18995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL474_19000	COG1702	phosphate starvation-inducible protein PhoH
AL474_19005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL474_19020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL474_19025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL474_19030	COG1862	Preprotein translocase
AL474_19035	COG0343	queuine tRNA-ribosyltransferase activity
AL474_19040	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL474_19045	COG2027	D-alanyl-D-alanine carboxypeptidase
AL474_19050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL474_19060	COG3468	outer membrane autotransporter barrel domain protein
AL474_19090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AL474_19095	COG0741	lytic transglycosylase activity
AL474_19100	COG0436	Aminotransferase
AL474_19110	COG0280	phosphate acetyltransferase
AL474_19110	COG0281	malic enzyme
AL474_19120	COG2732	(Barnase) inhibitor
AL474_19135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL474_19165	COG0248	Ppx GppA phosphatase
AL474_19175	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL474_19185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL474_19190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AL474_19195	COG1534	Rna-binding protein
AL474_19220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AL474_19235	COG1295	ribonuclease BN
AL474_19245	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AL474_19250	COG0745	RESPONSE REGULATOR receiver
AL474_19295	COG1022	Amp-dependent synthetase and ligase
AL474_19310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL474_19325	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL474_19340	COG1136	(ABC) transporter
AL474_19345	COG0084	hydrolase, TatD family'
AL474_19380	COG0613	PHP domain protein
AL474_19395	COG3539	Fimbrial protein
AL474_19400	COG0280	phosphate acetyltransferase
AL474_19400	COG0281	malic enzyme
AL474_19410	COG1522	sequence-specific DNA binding
AL474_19425	COG0567	Dehydrogenase, E1 component
AL474_19430	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL474_19435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL474_19440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AL474_19445	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_19450	COG0583	DNA-binding transcription factor activity
AL474_19460	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_19480	COG0180	Tryptophanyl-tRNA synthetase
AL474_19485	COG2183	response to ionizing radiation
AL474_19490	COG1199	ATP-dependent helicase activity
AL474_19500	COG0564	pseudouridine synthase activity
AL474_19510	COG3243	poly(R)-hydroxyalkanoic acid synthase
AL474_19515	COG1028	Short-chain dehydrogenase reductase Sdr
AL474_19520	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AL474_19575	COG0583	DNA-binding transcription factor activity
AL474_19585	COG2814	Major facilitator Superfamily
AL474_19600	COG1619	proteins homologs of microcin C7 resistance protein MccF
AL474_19615	COG2084	Dehydrogenase
AL474_19620	COG3181	Tripartite tricarboxylate transporter family receptor
AL474_19680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL474_19825	COG0463	Glycosyl transferase, family 2
AL474_19835	COG0840	transmembrane signaling receptor activity
AL474_19890	COG3842	ATPase activity
AL474_20075	COG4172	Belongs to the ABC transporter superfamily
AL474_20155	COG0537	adenosine 5'-monophosphoramidase activity
AL474_20220	COG1609	Transcriptional regulator
AL474_20395	COG1596	polysaccharide export
AL474_20395	COG1555	photosystem II stabilization
AL474_20400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AL474_20425	COG2333	competence protein COMEC
AL474_20425	COG0658	competence protein