locus-tag class description D8X09_00005 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D8X09_00015 ENOG4107QJE Chromosome Partitioning Protein D8X09_00025 ENOG4105FA0 parb-like partition protein D8X09_00050 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D8X09_00060 ENOG410683Z Preprotein translocase SecE subunit D8X09_00070 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D8X09_00075 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D8X09_00080 ENOG4108VZM 50s ribosomal protein L10 D8X09_00085 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D8X09_00090 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D8X09_00095 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D8X09_00125 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D8X09_00160 ENOG4105E39 Enoyl-CoA hydratase D8X09_00180 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D8X09_00185 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D8X09_00190 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D8X09_00195 ENOG4105E9Q Acyl-transferase D8X09_00210 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D8X09_00250 ENOG4105DWV Homoserine O-trans-acetylase D8X09_00255 ENOG4105DWV Homoserine O-trans-acetylase D8X09_00270 ENOG4105EYM Major Facilitator superfamily D8X09_00285 ENOG4105CDA abc transporter atp-binding protein D8X09_00290 ENOG4105DRP amino acid AbC transporter D8X09_00295 ENOG4105EAD ABC transporter D8X09_00300 ENOG4107RP9 extracellular solute-binding protein, family 3 D8X09_00355 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_00365 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D8X09_00395 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D8X09_00400 ENOG4108TGY Glutathione S-transferase D8X09_00415 ENOG4105CRE cytochrome C D8X09_00420 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D8X09_00450 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) D8X09_00455 ENOG4105D3Q Sugar transferase D8X09_00460 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D8X09_00470 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D8X09_00475 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D8X09_00480 ENOG4105J5G Transferase hexapeptide repeat containing protein D8X09_00490 ENOG4105D16 lipopolysaccharide heptosyltransferase i D8X09_00495 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D8X09_00505 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) D8X09_00520 ENOG4105DHJ ABC, transporter D8X09_00540 ENOG4105DZ1 carboxypeptidase D8X09_00545 ENOG4105F0I Aminotransferase D8X09_00550 ENOG4108Z43 UPF0250 protein D8X09_00555 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D8X09_00560 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D8X09_00565 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase D8X09_00595 ENOG4108Z33 Thiol disulfide Interchange Protein D8X09_00605 ENOG4105C75 arginyL-tRNA synthetase D8X09_00625 ENOG4105DRS transport system, permease D8X09_00630 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component D8X09_00635 ENOG4105BZ7 extracellular solute-binding protein family 1 D8X09_00640 ENOG4108IJ9 (ABC) transporter D8X09_00645 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D8X09_00655 ENOG4108IJ6 ABC transporter D8X09_00660 ENOG4105E0C molybdate abc transporter D8X09_00675 ENOG4105ETE Transcriptional regulator (LacI family D8X09_00685 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_00690 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D8X09_00700 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D8X09_00730 ENOG4105C7B Threonine dehydratase D8X09_00745 ENOG4105DRR Transcriptional regulator, GntR family D8X09_00790 ENOG4105P4J Allophanate hydrolase, subunit 1 D8X09_00800 ENOG4108M0I Transcriptional regulator D8X09_00805 ENOG4108JQ1 Dehydrogenase D8X09_00815 ENOG4105GR3 Histidine kinase D8X09_00825 ENOG4105BZU Histidine kinase D8X09_00830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D8X09_00835 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D8X09_00850 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D8X09_00870 ENOG4105HA9 of methanol dehydrogenase type D8X09_00880 ENOG4105C1J atp-dependent rna helicase D8X09_00885 ENOG410829K Lysine exporter protein (Lyse ygga) D8X09_00890 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D8X09_00900 ENOG4108UQY Iron-storage protein D8X09_00925 ENOG4105C72 UPF0176 protein D8X09_00930 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D8X09_00955 ENOG4105DHP deoxycytidine triphosphate deaminase D8X09_00980 ENOG4105CXN decarboxylase D8X09_00985 ENOG4105CBX hi0933 family D8X09_01005 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D8X09_01010 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D8X09_01015 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D8X09_01055 ENOG4105F2Z 3-oxoadipate enol-lactonase D8X09_01070 ENOG4107QNJ CoA-transferase subunit B D8X09_01080 ENOG4107HP6 Transcriptional regulator D8X09_01085 ENOG4105CHR reductase D8X09_01090 ENOG4105CRW Short chain fatty acid transporter D8X09_01095 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D8X09_01105 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) D8X09_01110 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D8X09_01120 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid D8X09_01145 ENOG4105C26 Dehydrogenase D8X09_01150 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D8X09_01155 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D8X09_01160 ENOG4105S7Q restriction endonuclease D8X09_01190 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase D8X09_01200 ENOG4105FDP GntR family transcriptional regulator D8X09_01205 ENOG4105CH5 extracellular solute-binding protein, family 7 D8X09_01210 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_01225 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D8X09_01230 ENOG4105DJ0 Poly(A) Polymerase D8X09_01245 ENOG4105CXB phosphoribosylaminoimidazole synthetase D8X09_01250 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D8X09_01255 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) D8X09_01260 ENOG4105DQR SNARE associated Golgi D8X09_01265 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D8X09_01270 ENOG4105K8N protein family UPF0079, ATPase D8X09_01275 ENOG4105C9Q fumarate hydratase class II D8X09_01295 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D8X09_01300 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_01330 ENOG4105C4M (Ubiquinol oxidase) subunit I D8X09_01335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D8X09_01345 ENOG4108JJ9 ABC, transporter D8X09_01350 ENOG4108JJ8 (ABC) transporter D8X09_01355 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D8X09_01400 ENOG4105KB2 stringent starvation protein b D8X09_01405 ENOG4107MKT Stringent starvation protein a D8X09_01410 ENOG4105EIX cytochrome c1 D8X09_01415 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D8X09_01420 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D8X09_01425 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D8X09_01430 ENOG4107QNR UPF0135 protein D8X09_01450 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D8X09_01455 ENOG4105DEF Extracellular solute-binding protein, family 5 D8X09_01460 ENOG4105F2M alpha beta hydrolase fold-3 domain protein D8X09_01470 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D8X09_01480 ENOG4105C01 Dihydroxy-acid dehydratase D8X09_01485 ENOG4105F27 Major Facilitator D8X09_01490 ENOG4105HEI LysR family (Transcriptional regulator D8X09_01500 ENOG4105GP2 5'(3')-deoxyribonucleotidase D8X09_01540 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_01545 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D8X09_01550 ENOG4105C0Z ABC transporter D8X09_01555 ENOG4108IV0 ABC, transporter D8X09_01570 ENOG4108UKI Enoyl-CoA hydratase D8X09_01575 ENOG4105C1G acyl-Coa dehydrogenase D8X09_01600 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase D8X09_01615 ENOG4105VCQ rubredoxin D8X09_01620 ENOG4108UJU UPF0301 protein D8X09_01625 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D8X09_01630 ENOG4105CXT aspartate transcarbamylase D8X09_01635 ENOG4105CD3 dihydroorotase D8X09_01640 ENOG4108Z20 Acyl-transferase D8X09_01645 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) D8X09_01655 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D8X09_01690 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D8X09_01710 ENOG4108NST exported protein D8X09_01720 ENOG4105BZU Histidine kinase D8X09_01725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D8X09_01730 ENOG4105CF1 Alkylated DNA repair protein D8X09_01740 ENOG4105EWC Purine nucleoside phosphorylase D8X09_01745 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) D8X09_01750 ENOG4105EHG Permease protein D8X09_01755 ENOG4107R4I Periplasmic binding protein D8X09_01760 ENOG4106QJH hemin transport protein D8X09_01770 ENOG4108S3W Anti-feci sigma factor, fecr D8X09_01775 ENOG4108SF5 RNA Polymerase D8X09_01800 ENOG4105CIF Ornithine Cyclodeaminase D8X09_01810 ENOG4105DRR Transcriptional regulator, GntR family D8X09_01830 ENOG4105C26 Dehydrogenase D8X09_01865 ENOG4105EN6 Membrane D8X09_01870 ENOG4105D82 Glutamate dehydrogenase D8X09_01875 ENOG4105CGK Exodeoxyribonuclease III D8X09_01880 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D8X09_01885 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D8X09_01890 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_01895 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D8X09_01900 ENOG4105DFF Rod shape-determining protein mreb D8X09_01905 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D8X09_01915 ENOG4105CJN penicillin-binding protein D8X09_01920 ENOG4105CNI cell division protein FtsW D8X09_01925 ENOG4105DG4 malate L-lactate dehydrogenase D8X09_01930 ENOG4107QPK )-transporter D8X09_01935 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) D8X09_01945 ENOG4105CAS nag kinase D8X09_01950 ENOG4105D01 (LipO)protein D8X09_01960 ENOG4105W4M Transport-associated protein D8X09_01965 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D8X09_01980 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D8X09_02010 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_02030 ENOG4105C3M thioredoxin reductase D8X09_02045 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D8X09_02050 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_02055 ENOG4105C7K acetolactate synthase D8X09_02070 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D8X09_02095 ENOG4105T38 integral membrane protein D8X09_02125 ENOG4107SH3 glycosyl transferase, family 39 D8X09_02145 ENOG4105D6U Sodium Glutamate Symporter D8X09_02155 ENOG4105CRW Short chain fatty acid transporter D8X09_02170 ENOG4107RZZ dna polymerase iii epsilon subunit D8X09_02185 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D8X09_02200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D8X09_02210 ENOG4108302 MgtC SapB transporter D8X09_02215 ENOG4105EE5 Membrane protein terC D8X09_02220 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_02225 ENOG4105E39 Enoyl-CoA hydratase D8X09_02235 ENOG4106NZI LysR family Transcriptional regulator D8X09_02240 ENOG4105CC9 acyl-Coa dehydrogenase D8X09_02250 ENOG4105CHU acetyl-coa acetyltransferase D8X09_02270 ENOG4105DND Transcriptional regulator D8X09_02275 ENOG4105VEQ Cold shock protein D8X09_02285 ENOG4108WYP Transcriptional regulator D8X09_02290 ENOG4105C26 Dehydrogenase D8X09_02295 ENOG4105CRW Short chain fatty acid transporter D8X09_02300 ENOG4108DEF Globin D8X09_02305 ENOG4108UQ8 endoribonuclease L-psp D8X09_02325 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F D8X09_02335 ENOG4105DND Transcriptional regulator D8X09_02340 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_02350 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) D8X09_02355 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) D8X09_02360 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D8X09_02365 ENOG4105EI2 Pseudouridine synthase D8X09_02370 ENOG4105C03 ribonuclease D8X09_02395 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D8X09_02400 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D8X09_02405 ENOG4105CWC Acetylornithine deacetylase D8X09_02410 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D8X09_02415 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) D8X09_02425 ENOG4105M4H endoribonuclease L-psp D8X09_02430 ENOG4107RH7 Nicotinate phosphoribosyltransferase D8X09_02435 ENOG4108Z4U Ferredoxin D8X09_02440 ENOG4105DP0 ferredoxin-NADP reductase D8X09_02450 ENOG4108R3D Electron transport complex D8X09_02455 ENOG4105CSM endonuclease III D8X09_02460 ENOG4105C0Z ABC transporter D8X09_02465 ENOG4108IV0 ABC, transporter D8X09_02475 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_02490 ENOG4105CM2 brancheD-chain amino acid aminotransferase D8X09_02495 ENOG4105C0Z ABC transporter D8X09_02510 ENOG4107ZYJ bioY protein D8X09_02515 ENOG4107QCX Transporter D8X09_02520 ENOG4108JJB ABC transporter D8X09_02525 ENOG4105E0X reductase D8X09_02545 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D8X09_02555 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D8X09_02560 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) D8X09_02565 ENOG4108UN4 phage SPO1 DNA polymerase-related protein D8X09_02570 ENOG41072GX Peptidase M22 Glycoprotease D8X09_02575 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D8X09_02585 ENOG4105E0F Histidine kinase D8X09_02590 ENOG4105D3R alkyl hydroperoxide reductase D8X09_02595 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D8X09_02615 ENOG4107YCY Transcriptional regulator D8X09_02635 ENOG4105C5I Dehydrogenase D8X09_02640 ENOG4105CHR reductase D8X09_02645 ENOG4105CBN LysR family transcriptional regulator D8X09_02655 ENOG4105C8Y Acetylornithine aminotransferase D8X09_02660 ENOG4105DBV ornithine carbamoyltransferase D8X09_02665 ENOG4105CDH Citrulline--aspartate ligase D8X09_02670 ENOG4105DFH Transport of potassium into the cell (By similarity) D8X09_02675 ENOG4105DHQ Histidine kinase D8X09_02680 ENOG4105XJC Two component transcriptional regulator (Winged helix family D8X09_02705 ENOG4105K70 DNA-binding protein D8X09_02710 ENOG4107E2E PKHD-type hydroxylase D8X09_02715 ENOG4105C28 cystathionine D8X09_02720 ENOG4105C2N RNA methyltransferase TrmH family group 3 D8X09_02725 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D8X09_02745 ENOG41082BV acetyltransferase D8X09_02750 ENOG4105RK9 auxin efflux carrier D8X09_02755 ENOG41066VF YeeE YedE family protein D8X09_02760 ENOG4105CBC glutamate synthase D8X09_02770 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D8X09_02780 ENOG41067HS methyltransferase D8X09_02815 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D8X09_02820 ENOG4105BZU Histidine kinase D8X09_02845 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein D8X09_02850 ENOG4105DUM transcriptional regulator, lysR family D8X09_02860 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein D8X09_02880 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D8X09_02885 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D8X09_02890 ENOG4108P8G outer membrane autotransporter barrel D8X09_02895 ENOG4107S2Z UPF0761 membrane protein D8X09_02900 ENOG41080IJ Diacylglycerol kinase D8X09_02905 ENOG4105CEP NADH dehydrogenase D8X09_02910 ENOG4105SKN orotidine 5''-phosphate decarboxylase D8X09_02915 ENOG4108I62 cina-like protein D8X09_02920 ENOG4108ZAI phosphatidylglycerophosphatase a D8X09_02925 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D8X09_02930 ENOG4107YIM Involved in the transcription termination process (By similarity) D8X09_02935 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D8X09_02940 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D8X09_03000 ENOG4106H78 methyltransferase D8X09_03005 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D8X09_03010 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D8X09_03015 ENOG4105DKK Benzoate D8X09_03030 ENOG41082BM Transcriptional regulator, arsr family D8X09_03060 ENOG4108JQ6 ABC transporter D8X09_03080 ENOG4105C6K Malic enzyme D8X09_03140 ENOG4105CC0 LysR family Transcriptional regulator D8X09_03155 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate D8X09_03160 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) D8X09_03180 ENOG41069M3 Transcriptional regulator D8X09_03185 ENOG4107TH8 cina domain protein D8X09_03205 ENOG4105C1J atp-dependent rna helicase D8X09_03220 ENOG4105CM2 brancheD-chain amino acid aminotransferase D8X09_03235 ENOG4105DNZ Alpha Beta Hydrolase D8X09_03240 ENOG4105ERG peptidase m48, ste24p D8X09_03255 ENOG4108Z9W Outer membrane porin D8X09_03280 ENOG4107RAQ aminopeptidase D8X09_03290 ENOG4105D0A hydroxylase D8X09_03295 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D8X09_03310 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) D8X09_03315 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D8X09_03330 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D8X09_03335 ENOG4105C9U ATP-dependent DNA helicase RecQ D8X09_03355 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_03365 ENOG4108HWV )-transporter D8X09_03370 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_03375 ENOG4105C0Z ABC transporter D8X09_03380 ENOG4108IV0 ABC, transporter D8X09_03395 ENOG4105D01 (LipO)protein D8X09_03605 ENOG4108RAV Conserved protein D8X09_03620 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D8X09_03625 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D8X09_03630 ENOG4107YD3 Thioesterase D8X09_03635 ENOG4105E02 MotA TolQ exbB proton channel D8X09_03640 ENOG4105M8F Biopolymer transport protein exbD tolR D8X09_03650 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D8X09_03655 ENOG4105KCK Peptidoglycan-associated lipoprotein D8X09_03665 ENOG4105EHG Permease protein D8X09_03710 ENOG4105CA9 Pyruvate kinase D8X09_03715 ENOG4105BZW Glycerate kinase D8X09_03720 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D8X09_03725 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D8X09_03730 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) D8X09_03735 ENOG4105EHM Aminoglycoside phosphotransferase D8X09_03740 ENOG4108S0S Nucleotidyl transferase D8X09_03750 ENOG4105KZX Pterin carbinolamine dehydratase D8X09_03775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D8X09_03780 ENOG4105EUF amidase EC 3.5.1.4 D8X09_03820 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) D8X09_03835 ENOG4108YYC ycei family D8X09_03840 ENOG4105E0K tonB-dependent siderophore receptor D8X09_03845 ENOG4108S3W Anti-feci sigma factor, fecr D8X09_03885 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D8X09_03890 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D8X09_03895 ENOG4105K46 50S ribosomal protein l27 D8X09_03900 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D8X09_03910 ENOG4105EAH synthase D8X09_03920 ENOG4105RQF LysR family Transcriptional regulator D8X09_03930 ENOG4107TYC hydantoinase B oxoprolinase D8X09_03935 ENOG4105DDR sarcosine oxidase (Beta subunit) D8X09_03945 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D8X09_03955 ENOG41090Q8 at two internal lysine residues, thereby converting it to the active toxin. The acyl donor is ACP D8X09_03970 ENOG4108JJA ABC, transporter D8X09_03990 ENOG4107RP9 extracellular solute-binding protein, family 3 D8X09_04000 ENOG4105DRP amino acid AbC transporter D8X09_04005 ENOG4105CDA abc transporter atp-binding protein D8X09_04025 ENOG4105CHR reductase D8X09_04035 ENOG4108WYP Transcriptional regulator D8X09_04045 ENOG4105DRR Transcriptional regulator, GntR family D8X09_04050 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D8X09_04055 ENOG4105CEY Amp-dependent synthetase and ligase D8X09_04065 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D8X09_04075 ENOG4107UWC ABC, transporter D8X09_04085 ENOG4105C7K acetolactate synthase D8X09_04105 ENOG4105CD8 aminopeptidase N D8X09_04110 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 D8X09_04130 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) D8X09_04135 ENOG4108JA2 transcriptioN-repair coupling factor D8X09_04140 ENOG4105EAC phosphoserine phosphatase D8X09_04145 ENOG4105F04 LysR family Transcriptional regulator D8X09_04155 ENOG4105C7K acetolactate synthase D8X09_04160 ENOG4105CHR reductase D8X09_04170 ENOG4108ESX Receptor D8X09_04175 ENOG4108ESX Receptor D8X09_04185 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D8X09_04190 ENOG4105C8S subunit m D8X09_04200 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D8X09_04205 ENOG4105DF2 NADH dehydrogenase subunit j D8X09_04210 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D8X09_04215 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) D8X09_04220 ENOG4108IEH NADH dehydrogenase subunit g D8X09_04235 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D8X09_04240 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D8X09_04245 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D8X09_04250 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D8X09_04255 ENOG4108Z9W Outer membrane porin D8X09_04285 ENOG410841Q phosphoesterase PA-phosphatase related protein D8X09_04295 ENOG4105CBD Diacylglycerol kinase D8X09_04300 ENOG4105DUM transcriptional regulator, lysR family D8X09_04305 ENOG4105C94 Transporter D8X09_04315 ENOG4105KVH Transcriptional regulator D8X09_04320 ENOG4105ENT Efflux transporter rnd family, mfp subunit D8X09_04325 ENOG4105BZS acriflavin resistance protein D8X09_04330 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D8X09_04340 ENOG41090JD Blue (Type 1) copper domain protein D8X09_04360 ENOG4105CJP fad dependent oxidoreductase D8X09_04380 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase D8X09_04385 ENOG4105C28 cystathionine D8X09_04390 ENOG4107NQ8 LysR family Transcriptional regulator D8X09_04395 ENOG4107EXU Short-chain dehydrogenase reductase Sdr D8X09_04425 ENOG4105DV9 Methylaspartate ammonia-lyase D8X09_04435 ENOG4105C94 Transporter D8X09_04450 ENOG4105CP7 Triose-phosphate isomerase D8X09_04470 ENOG4105C7B Threonine dehydratase D8X09_04490 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D8X09_04505 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase D8X09_04510 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D8X09_04515 ENOG4108ZP8 Acetolactate synthase small subunit D8X09_04520 ENOG4105C7K acetolactate synthase D8X09_04535 ENOG4108JJ7 ABC transporter D8X09_04540 ENOG4105FQ6 thiopurine methyltransferase D8X09_04560 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) D8X09_04580 ENOG4105DHT Metal Dependent Phosphohydrolase D8X09_04595 ENOG4107QSA Oxaloacetate decarboxylase D8X09_04615 ENOG4105FDP GntR family transcriptional regulator D8X09_04620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D8X09_04670 ENOG4108JJ7 ABC transporter D8X09_04680 ENOG4105CPC Aldo Keto reductase D8X09_04695 ENOG4108R1E Serine threonine protein phosphatase 1 D8X09_04700 ENOG4108JQC penicillin-binding protein 1A D8X09_04720 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D8X09_04730 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D8X09_04735 ENOG4108KB2 LysR family Transcriptional regulator D8X09_04765 ENOG4105F27 Major Facilitator D8X09_04770 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D8X09_04775 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D8X09_04780 ENOG4105UYK outer membrane protein a D8X09_04785 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D8X09_04790 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) D8X09_04800 ENOG4105EVN Prephenate dehydrogenase D8X09_04805 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D8X09_04810 ENOG4105CAT Cytidine monophosphate kinase D8X09_04815 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D8X09_04830 ENOG4105CFV Tetratricopeptide repeat protein D8X09_04835 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D8X09_04840 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) D8X09_04845 ENOG4105KQC Competence protein D8X09_04855 ENOG4105C6T cysteine synthase D8X09_04860 ENOG4105CVE Lytic murein transglycosylase D8X09_04870 ENOG4105BZJ Electron transfer flavoprotein D8X09_04875 ENOG4105C10 Electron transfer flavoprotein D8X09_04880 ENOG4105CSU acyl-Coa dehydrogenase D8X09_04885 ENOG4105D3R alkyl hydroperoxide reductase D8X09_04890 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D8X09_04905 ENOG4108IJ6 ABC transporter D8X09_04940 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D8X09_04945 ENOG4105P8F nudix hydrolase D8X09_04955 ENOG4105CPC Aldo Keto reductase D8X09_04970 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) D8X09_04975 ENOG4105FE9 pseudouridine synthase D8X09_04980 ENOG4105JQN Transcriptional regulator D8X09_04990 ENOG4105BZS acriflavin resistance protein D8X09_04995 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D8X09_05010 ENOG4105DGW oligopeptidase A D8X09_05020 ENOG4108ZXC Two component transcriptional regulator, luxr family D8X09_05025 ENOG4105BZU Histidine kinase D8X09_05030 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D8X09_05035 ENOG4107QSN dihydrolipoamide acetyltransferase D8X09_05040 ENOG4107QN2 dihydrolipoyl dehydrogenase D8X09_05045 ENOG4105I03 Flagellin D8X09_05055 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D8X09_05060 ENOG4105CV1 Transketolase (EC 2.2.1.1) D8X09_05065 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D8X09_05070 ENOG4105BZA Phosphoglycerate kinase D8X09_05075 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D8X09_05080 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D8X09_05095 ENOG4108SHQ Glutathione S-transferase D8X09_05125 ENOG4108UMN azlc family D8X09_05135 ENOG4108RIR Molybdenum cofactor biosynthesis protein D8X09_05145 ENOG4105DR5 peptidase D8X09_05155 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D8X09_05165 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D8X09_05170 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) D8X09_05175 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region D8X09_05180 ENOG4107RD7 Flagellar Motor Protein, MotA D8X09_05185 ENOG4105ER2 Ompa motb domain protein D8X09_05195 ENOG4105CBS Chea signal transduction histidine kinase D8X09_05200 ENOG4108V3W Chemotaxis protein, CheW D8X09_05205 ENOG4105C8Q Methyl-accepting chemotaxis D8X09_05215 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D8X09_05220 ENOG4108VYJ response regulator receiver protein D8X09_05225 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) D8X09_05250 ENOG4107SET aldo keto reductase D8X09_05260 ENOG4108JU5 Magnesium and cobalt efflux protein D8X09_05265 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D8X09_05270 ENOG4105C9A Phoh family D8X09_05275 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D8X09_05290 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D8X09_05295 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D8X09_05300 ENOG4105VIE preprotein translocase, subunit YajC D8X09_05305 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D8X09_05310 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D8X09_05315 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase D8X09_05320 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D8X09_05330 ENOG4108P8G outer membrane autotransporter barrel D8X09_05335 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D8X09_05360 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D8X09_05365 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division D8X09_05375 ENOG4105CHM Aminotransferase D8X09_05385 ENOG4105C6K Malic enzyme D8X09_05410 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D8X09_05415 ENOG4105E2Z phosphate ABC transporter (Permease D8X09_05420 ENOG4105C8U phosphate abc transporter D8X09_05425 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) D8X09_05435 ENOG4105C9X ppx gppa phosphatase D8X09_05445 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D8X09_05455 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D8X09_05460 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D8X09_05465 ENOG4105HBR Rna-binding protein D8X09_05495 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D8X09_05510 ENOG4107S2Z UPF0761 membrane protein D8X09_05520 ENOG4105CNG UPF0061 protein D8X09_05525 ENOG4106WF9 DNA-binding transcriptional regulator TorR D8X09_05530 ENOG4105BZU Histidine kinase D8X09_05540 ENOG4105C0Z ABC transporter D8X09_05560 ENOG4108IV0 ABC, transporter D8X09_05565 ENOG4108IQE Amp-dependent synthetase and ligase D8X09_05580 ENOG4105CRK lysyL-tRNA synthetase D8X09_05585 ENOG410904N short-chain dehydrogenase reductase D8X09_05595 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D8X09_05610 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D8X09_05615 ENOG4105F8V Hydrolase, tatD family D8X09_05640 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 D8X09_05650 ENOG4105DB7 PHP domain protein D8X09_05670 ENOG4105X0I Fimbrial D8X09_05675 ENOG4105C6K Malic enzyme D8X09_05680 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D8X09_05685 ENOG4108YXU transcriptional regulator AsnC family D8X09_05695 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D8X09_05700 ENOG4105C7S Dehydrogenase D8X09_05705 ENOG4107QN2 dihydrolipoyl dehydrogenase D8X09_05710 ENOG4105D6Z AFG1 family ATPase D8X09_05715 ENOG4105CHR reductase D8X09_05720 ENOG4107RSM transcriptional regulator D8X09_05735 ENOG4105CHR reductase D8X09_05755 ENOG4105C31 Tryptophanyl-tRNA synthetase D8X09_05760 ENOG4105BZM domain protein D8X09_05765 ENOG4105DVT helicase D8X09_05775 ENOG4105C34 Pseudouridine synthase D8X09_05780 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D8X09_05785 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class D8X09_05790 ENOG4105CHR reductase D8X09_05795 ENOG4108NVM synthesis repressor PhaR D8X09_05820 ENOG4105JAB phenazine biosynthesis protein, phzf family D8X09_05845 ENOG4105DIA mandelate racemase muconate lactonizing D8X09_05850 ENOG4105DDW LysR family Transcriptional regulator D8X09_05855 ENOG4105CHR reductase D8X09_05860 ENOG4105C0R drug resistance transporter emrb qaca subfamily D8X09_05875 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D8X09_05890 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D8X09_05920 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) D8X09_05950 ENOG4105DRP amino acid AbC transporter D8X09_05955 ENOG4105EAD ABC transporter D8X09_05960 ENOG4105EAB amino acid AbC transporter D8X09_05995 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D8X09_06000 ENOG4108KPJ rna polymerase sigma factor D8X09_06010 ENOG4105VRT cytoplasmic protein D8X09_06015 ENOG4108YZ4 nudix hydrolase D8X09_06030 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D8X09_06035 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D8X09_06065 ENOG4108P8G outer membrane autotransporter barrel D8X09_06075 ENOG4105EQN UPF0261 protein D8X09_06110 ENOG4105CJ2 (LipO)protein D8X09_06130 ENOG4105CJ1 ABC, transporter D8X09_06145 ENOG4107Z6W Protein CrcB homolog D8X09_06150 ENOG4105CVN desaturase D8X09_06150 ENOG4105CVN desaturase D8X09_06165 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D8X09_06170 ENOG4105CHR reductase D8X09_06190 ENOG4105CP2 von willebrand factor, type a D8X09_06195 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D8X09_06210 ENOG4107QI1 Mate efflux family protein D8X09_06220 ENOG4105NRA 50s ribosomal protein l31 type b D8X09_06225 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) D8X09_06230 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) D8X09_06235 ENOG4105W5Q DNA repair protein (RadC D8X09_06240 ENOG4108YZY peptidylprolyl cis-trans isomerase D8X09_06250 ENOG4108RXX maleylacetoacetate isomerase D8X09_06270 ENOG4105CKI cobalamin synthesis protein D8X09_06280 ENOG4105EJC lysr family transcriptional regulator D8X09_06290 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) D8X09_06295 ENOG4105FE9 pseudouridine synthase D8X09_06300 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D8X09_06305 ENOG4105CHV Transcription elongation factor NusA D8X09_06310 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D8X09_06315 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D8X09_06320 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D8X09_06340 ENOG4108URH decarboxylase D8X09_06345 ENOG4105C2M dna polymerase I D8X09_06355 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) D8X09_06360 ENOG4105EAM Na Pi-cotransporter D8X09_06365 ENOG4105EJQ L-serine dehydratase D8X09_06370 ENOG4105WPN DNA integration recombination invertion protein D8X09_06375 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) D8X09_06385 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D8X09_06390 ENOG4105K63 Thioredoxin D8X09_06395 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D8X09_06405 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D8X09_06435 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D8X09_06440 ENOG4108IV0 ABC, transporter D8X09_06445 ENOG4105C0Z ABC transporter D8X09_06450 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D8X09_06455 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_06460 ENOG4105CP9 extracellular ligand-binding receptor D8X09_06470 ENOG4105EX9 Membrane D8X09_06475 ENOG4105II7 pyrroline-5-carboxylate reductase D8X09_06480 ENOG4105BZ7 extracellular solute-binding protein family 1 D8X09_06485 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component D8X09_06495 ENOG4108IJ9 (ABC) transporter D8X09_06500 ENOG4105CP9 extracellular ligand-binding receptor D8X09_06535 ENOG4105D01 (LipO)protein D8X09_06560 ENOG4105DF9 Lipoate-protein, ligase D8X09_06575 ENOG4105CYM Glutathione S-transferase D8X09_06595 ENOG4105WAP TPR repeat-containing protein D8X09_06600 ENOG410846T CoA-transferase family III D8X09_06630 ENOG4108VGI doxx family D8X09_06645 ENOG4105CPC Aldo Keto reductase D8X09_06650 ENOG41068KF Universal stress protein D8X09_06665 ENOG4105CSW GntR family transcriptional regulator D8X09_06670 ENOG4105DFA alanine racemase domain protein D8X09_06675 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) D8X09_06695 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D8X09_06705 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D8X09_06755 ENOG4105DZQ phospholipase D Transphosphatidylase D8X09_06760 ENOG4105X23 Endonuclease Exonuclease phosphatase D8X09_06770 ENOG4105NTW Transcriptional regulator D8X09_06790 ENOG4105HEI LysR family (Transcriptional regulator D8X09_06805 ENOG4108PVQ transcriptional regulator D8X09_06825 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_06835 ENOG4105ETE Transcriptional regulator (LacI family D8X09_06855 ENOG4105CMJ mandelate racemase muconate lactonizing D8X09_06860 ENOG4108KF8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D8X09_06870 ENOG4105CDA abc transporter atp-binding protein D8X09_06875 ENOG4105E5Q amino acid AbC transporter D8X09_06890 ENOG4105D00 flagellar biosynthetic protein flhB D8X09_06910 ENOG4105M9M anti-sigma28 factor FlgM D8X09_06920 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D8X09_06925 ENOG4108ZC9 flagellar basal-body rod protein flgc D8X09_06930 ENOG4105W00 Flagellar hook capping protein D8X09_06935 ENOG4105BZE flagellar hook protein, FlgE D8X09_06940 ENOG4108KPB Flagellar basal-body rod protein FlgF D8X09_06945 ENOG4105CGA flagellar basal-body rod protein FlgG D8X09_06950 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D8X09_06955 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D8X09_06960 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D8X09_06965 ENOG4105E1Q flagellar hook-associated protein D8X09_06970 ENOG4105DTJ flagellar hook-associated protein D8X09_06975 ENOG4105C8Q Methyl-accepting chemotaxis D8X09_06980 ENOG4105C8Q Methyl-accepting chemotaxis D8X09_06985 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D8X09_06995 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D8X09_07000 ENOG4105VS8 Flagellar biosynthetic protein fliq D8X09_07005 ENOG4105CN7 Flagellar biosynthetic protein FliP D8X09_07015 ENOG4105DD5 Flagellar motor switch protein D8X09_07020 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D8X09_07025 ENOG4107ZI8 flagellar basal body-associated protein flil D8X09_07050 ENOG4108JIR Flagellum-specific ATP synthase D8X09_07060 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D8X09_07065 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D8X09_07070 ENOG4105VQ0 flagellar hook-basal body complex protein fliE D8X09_07080 ENOG4105D00 flagellar biosynthetic protein flhB D8X09_07100 ENOG4105MQ3 flagellar protein FliS D8X09_07105 ENOG4105DTS flagellar hook-associated D8X09_07115 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D8X09_07130 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D8X09_07145 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D8X09_07150 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D8X09_07155 ENOG4105CE9 30S ribosomal protein S2 D8X09_07160 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D8X09_07165 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D8X09_07170 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D8X09_07175 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D8X09_07180 ENOG4105KNE Phosphatidate cytidylyltransferase D8X09_07185 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D8X09_07190 ENOG4105DZP Membrane-associated zinc metalloprotease D8X09_07195 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D8X09_07200 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) D8X09_07205 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D8X09_07210 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D8X09_07220 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D8X09_07225 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D8X09_07235 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D8X09_07240 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D8X09_07245 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D8X09_07260 ENOG4107QX8 SPFH domain, Band 7 family protein D8X09_07265 ENOG4105BZU Histidine kinase D8X09_07270 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D8X09_07280 ENOG4108Z1B Cyclase dehydrase D8X09_07290 ENOG4105C1G acyl-Coa dehydrogenase D8X09_07295 ENOG4108IPT Naphthoate synthase D8X09_07300 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D8X09_07325 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D8X09_07330 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D8X09_07335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D8X09_07345 ENOG4105CVJ phosphoglycerate mutase D8X09_07355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D8X09_07380 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D8X09_07385 ENOG4105ERG peptidase m48, ste24p D8X09_07390 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b D8X09_07395 ENOG4105CVM Molybdenum cofactor synthesis domain protein D8X09_07400 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D8X09_07435 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D8X09_07470 ENOG4108JJB ABC transporter D8X09_07480 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D8X09_07485 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D8X09_07490 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D8X09_07495 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D8X09_07505 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D8X09_07510 ENOG4105CH5 extracellular solute-binding protein, family 7 D8X09_07520 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_07525 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D8X09_07540 ENOG4105D1Q UPF0246 protein D8X09_07560 ENOG4105BZU Histidine kinase D8X09_07580 ENOG4108T94 DNA-binding transcriptional activator BglJ D8X09_07585 ENOG4105C22 threonyL-tRNA synthetase D8X09_07590 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D8X09_07595 ENOG4105D7Z glutathione synthase D8X09_07605 ENOG41080Z8 PHOSPHOCARRIER protein D8X09_07610 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D8X09_07625 ENOG4105CIF Ornithine Cyclodeaminase D8X09_07675 ENOG4105IW1 AmiS UreI transporter D8X09_07695 ENOG4105D2N Aldolase D8X09_07705 ENOG4105C8V SAICAR synthetase D8X09_07710 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation D8X09_07715 ENOG4105WJ3 XRE family Transcriptional regulator D8X09_07725 ENOG4105RXK Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) D8X09_07730 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D8X09_07735 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D8X09_07740 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D8X09_07750 ENOG4108FUF Transcriptional regulator, IclR family D8X09_07755 ENOG4105CYW agmatinase D8X09_07765 ENOG4105E5Q amino acid AbC transporter D8X09_07770 ENOG4105CDA abc transporter atp-binding protein D8X09_07785 ENOG4105C1G acyl-Coa dehydrogenase D8X09_07790 ENOG4105C7K acetolactate synthase D8X09_07795 ENOG4105ETT transcriptional Regulator, LysR family D8X09_07800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D8X09_07805 ENOG4108Z66 YbaK ebsC protein D8X09_07810 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) D8X09_07825 ENOG41061WM D-Alanyl-D-Alanine D8X09_07835 ENOG4107RGD Major Facilitator superfamily D8X09_07845 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation D8X09_07855 ENOG4107QMP dna polymerase iii subunits gamma and tau D8X09_07860 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) D8X09_07865 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D8X09_07885 ENOG4105CGZ zinc metallopeptidase D8X09_07890 ENOG4107RTD sua5 ycio yrdc ywlc family protein D8X09_07935 ENOG4105WKW Pfam:DUF1458 D8X09_07940 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D8X09_07945 ENOG4105EZE Cupin 4 family protein D8X09_07955 ENOG4105GJM (LipO)protein D8X09_07960 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D8X09_07975 ENOG4107R0W ABC transporter D8X09_07980 ENOG4105E5Q amino acid AbC transporter D8X09_07985 ENOG4105CDA abc transporter atp-binding protein D8X09_07990 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D8X09_07995 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D8X09_08000 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D8X09_08010 ENOG41090Y2 cytochrome C D8X09_08015 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D8X09_08020 ENOG4105K4H Nlp p60 protein D8X09_08025 ENOG4105FYV Amp nucleosidase D8X09_08045 ENOG4105DSJ YicC domain protein D8X09_08050 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D8X09_08060 ENOG4105DUM transcriptional regulator, lysR family D8X09_08065 ENOG4105C8Q Methyl-accepting chemotaxis D8X09_08070 ENOG4105BZU Histidine kinase D8X09_08075 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D8X09_08085 ENOG4105CSA Coproporphyrinogen iii oxidase D8X09_08090 ENOG4105C5F glutamine synthetase D8X09_08095 ENOG4105CUX Signal transduction histidine kinase D8X09_08100 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D8X09_08105 ENOG4105EQ1 Transcriptional regulator D8X09_08115 ENOG4105EUB pirin domain protein D8X09_08125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D8X09_08130 ENOG4107RCV ABC transporter, permease D8X09_08135 ENOG4107QKW extracellular solute-binding protein family 1 D8X09_08140 ENOG4105DP0 ferredoxin-NADP reductase D8X09_08145 ENOG4105HEI LysR family (Transcriptional regulator D8X09_08155 ENOG4105CV8 reductase D8X09_08165 ENOG4105KME endoribonuclease L-psp D8X09_08170 ENOG4105CB5 ATP-dependent DNA helicase recG D8X09_08175 ENOG4105C5Q Transcriptional regulator D8X09_08180 ENOG4105JQN Transcriptional regulator D8X09_08185 ENOG4105C26 Dehydrogenase D8X09_08210 ENOG4105K64 Glycosyl transferase, family 2 D8X09_08230 ENOG4107TAE Glycosyl transferase (Group 1 D8X09_08245 ENOG4107QQG Dehydrogenase D8X09_08255 ENOG4105E12 capsule polysaccharide D8X09_08260 ENOG41084CK capsule polysaccharide D8X09_08270 ENOG4108W6C Dehydrogenase D8X09_08295 ENOG4108IV0 ABC, transporter D8X09_08300 ENOG4105C0Z ABC transporter D8X09_08315 ENOG4108ZCF integral membrane protein D8X09_08340 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D8X09_08375 ENOG4105ENH Sulfatase D8X09_08400 ENOG4105WH1 Two component transcriptional regulator luxr family D8X09_08410 ENOG4105W08 virulence gene repressor rsal D8X09_08420 ENOG4108K3A Glutathione S-transferase D8X09_08450 ENOG4105ERH Fumarylacetoacetate hydrolase D8X09_08455 ENOG4105F6U Short-chain dehydrogenase reductase Sdr D8X09_08500 ENOG4105CAU Arsenical resistance protein, ArsH D8X09_08530 ENOG4105CHR reductase D8X09_08555 ENOG4105D65 subunit l D8X09_08560 ENOG4108ZE9 Monovalent cation H antiporter subunit C D8X09_08565 ENOG4107R4Z monovalent cation h antiporter subunit d D8X09_08570 ENOG4105SC1 monovalent cation H antiporter subunit E D8X09_08575 ENOG4105W4C monovalent cation H antiporter subunit F D8X09_08595 ENOG4106TCE D8X09_08600 ENOG4108Z6B deaminase D8X09_08605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D8X09_08610 ENOG4105CGU Enoyl-CoA hydratase D8X09_08615 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_08625 ENOG4105CH5 extracellular solute-binding protein, family 7 D8X09_08630 ENOG4105C5H ABC transporter D8X09_08665 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D8X09_08670 ENOG4105KPV Transcriptional regulator D8X09_08675 ENOG4105MWK D-amino acid dehydrogenase, small subunit D8X09_08690 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) D8X09_08695 ENOG4105HHA aminodeoxychorismate lyase D8X09_08700 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D8X09_08705 ENOG4105C6E dna polymerase iii D8X09_08710 ENOG4105F8V Hydrolase, tatD family D8X09_08725 ENOG4106PMH Extracellular solute-binding protein family 3 D8X09_08735 ENOG4105CDA abc transporter atp-binding protein D8X09_08745 ENOG4105D82 Glutamate dehydrogenase D8X09_08755 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D8X09_08760 ENOG4105C7K acetolactate synthase D8X09_08770 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_08830 ENOG4105CFM UPF0317 protein D8X09_08840 ENOG4105BZU Histidine kinase D8X09_08845 ENOG4108WQH regulatoR D8X09_08850 ENOG4108QZZ filamentous hemagglutinin D8X09_08860 ENOG4105GQR Chaperone D8X09_08870 ENOG41074HU Fimbrial adhesin D8X09_08875 ENOG4108YH7 hemolysin D8X09_08890 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D8X09_08940 ENOG4105D64 Mechanosensitive ion channel D8X09_08960 ENOG4105ECY inositol monophosphatase D8X09_08965 ENOG4105EE5 Membrane protein terC D8X09_08970 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D8X09_08975 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) D8X09_08990 ENOG4105C8N cysteinyl-tRNA synthetase D8X09_09000 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D8X09_09010 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D8X09_09015 ENOG4105CFH Aspartokinase D8X09_09040 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) D8X09_09045 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter D8X09_09050 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_09055 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D8X09_09060 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) D8X09_09065 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) D8X09_09070 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D8X09_09080 ENOG4105RQF LysR family Transcriptional regulator D8X09_09095 ENOG4105F38 ABC transporter, permease D8X09_09105 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D8X09_09115 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D8X09_09120 ENOG4107HP6 Transcriptional regulator D8X09_09125 ENOG4105K4P CoA-binding domain protein D8X09_09135 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) D8X09_09160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D8X09_09170 ENOG4105CND Glycosyl transferase, family 2 D8X09_09175 ENOG4107BJW polysaccharide deacetylase D8X09_09195 ENOG4108VHT MarR family transcriptional regulator D8X09_09200 ENOG4105WH1 Two component transcriptional regulator luxr family D8X09_09215 ENOG4107QP8 phosphohexose isomerase D8X09_09220 ENOG4105D7W serine acetyltransferase D8X09_09230 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D8X09_09235 ENOG4105ECY inositol monophosphatase D8X09_09240 ENOG4105C26 Dehydrogenase D8X09_09245 ENOG4108JPW Aminotransferase D8X09_09260 ENOG4105C4R Atp-dependent dna helicase D8X09_09265 ENOG4105D7N magnesium and cobalt transport protein CorA D8X09_09275 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein D8X09_09285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D8X09_09290 ENOG4108JQ6 ABC transporter D8X09_09320 ENOG4105BZU Histidine kinase D8X09_09390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D8X09_09405 ENOG4105EMN RNA polymerase sigma factor D8X09_09415 ENOG4105XUA cytochrome c D8X09_09420 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D8X09_09435 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b D8X09_09440 ENOG4107QM5 aconitate hydratase D8X09_09470 ENOG41090EK ompa motb domain protein D8X09_09480 ENOG4107QIJ Aconitate hydratase 2 D8X09_09505 ENOG4108594 Permease of the drug metabolite transporter D8X09_09510 ENOG4105P69 integral membrane protein D8X09_09530 ENOG4105CMU LysR family (Transcriptional regulator D8X09_09535 ENOG4105CYC Transferase D8X09_09545 ENOG4108MGI Transcriptional regulator D8X09_09590 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) D8X09_09595 ENOG4105EUF amidase EC 3.5.1.4 D8X09_09605 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) D8X09_09620 ENOG4105C8T Leucyl-tRNA synthetase D8X09_09630 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes D8X09_09655 ENOG4105W0E 50S ribosomal protein L33 D8X09_09660 ENOG4105KDC 50s ribosomal protein l28 D8X09_09665 ENOG4105C2C drug resistance transporter, Bcr CflA D8X09_09685 ENOG4108HQS Glycine betaine D8X09_09690 ENOG4108IJ7 Glycine betaine D8X09_09700 ENOG4105CHU acetyl-coa acetyltransferase D8X09_09710 ENOG4105DRR Transcriptional regulator, GntR family D8X09_09720 ENOG4105E39 Enoyl-CoA hydratase D8X09_09735 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D8X09_09750 ENOG4105D5T phosphonate abc transporter D8X09_09755 ENOG4105F4R Transcriptional regulator mode D8X09_09775 ENOG4105C1P efflux transporter, rnd family, mfp subunit D8X09_09780 ENOG4105BZS acriflavin resistance protein D8X09_09790 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D8X09_09795 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D8X09_09800 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) D8X09_09805 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D8X09_09810 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D8X09_09820 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D8X09_09845 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_09855 ENOG4105FUY alpha subunit D8X09_09860 ENOG4108SBK dioxygenase, subunit beta D8X09_09865 ENOG4105E39 Enoyl-CoA hydratase D8X09_09870 ENOG4105CHR reductase D8X09_09875 ENOG4107Z7P Ferredoxin D8X09_09880 ENOG410846T CoA-transferase family III D8X09_09890 ENOG4105DZS Phenylacetate-CoA ligase D8X09_09895 ENOG4105CHU acetyl-coa acetyltransferase D8X09_09915 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D8X09_09940 ENOG4105VIG Sec-independent protein translocase protein TatC D8X09_10020 ENOG4105DC8 reductase D8X09_10045 ENOG4105EXG Transcriptional regulator D8X09_10070 ENOG4105CF7 AraC family transcriptional regulator D8X09_10120 ENOG4105BZ1 (ABC) transporter D8X09_10145 ENOG4105CHH sulfate transporter D8X09_10180 ENOG4105KCV RNA signal recognition particle 4.5S RNA D8X09_10185 ENOG4107ZY0 Phenazine biosynthesis-like protein D8X09_10195 ENOG4106BRA Membrane D8X09_10210 ENOG4105C26 Dehydrogenase D8X09_10215 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D8X09_10240 ENOG4105VAW lrga family D8X09_10245 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D8X09_10255 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D8X09_10260 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D8X09_10325 ENOG4105DA5 (ABC) transporter D8X09_10330 ENOG4105E3A (ABC) transporter D8X09_10335 ENOG4105IPI Membrane D8X09_10380 ENOG4105VCC 30S ribosomal protein S21 D8X09_10385 ENOG4108UGV hypoxanthine phosphoribosyltransferase D8X09_10390 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D8X09_10395 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) D8X09_10400 ENOG4105EPW hflc protein D8X09_10405 ENOG4107QJR hflk protein D8X09_10410 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D8X09_10415 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D8X09_10420 ENOG4105CIH Imidazole acetol-phosphate transaminase D8X09_10425 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D8X09_10430 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D8X09_10435 ENOG4105N21 Membrane D8X09_10440 ENOG4105CUT histidyl-tRNA synthetase D8X09_10445 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D8X09_10455 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D8X09_10460 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D8X09_10465 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D8X09_10480 ENOG4105DHQ Histidine kinase D8X09_10505 ENOG4105C9B Cysteine desulfurase D8X09_10510 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D8X09_10515 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D8X09_10520 ENOG4105K5M 30s ribosomal protein S16 D8X09_10530 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) D8X09_10535 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D8X09_10580 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_10585 ENOG4108JQ6 ABC transporter D8X09_10620 ENOG4105C5Q Transcriptional regulator D8X09_10630 ENOG4105MWK D-amino acid dehydrogenase, small subunit D8X09_10640 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D8X09_10675 ENOG4105CGU Enoyl-CoA hydratase D8X09_10690 ENOG4105WVQ Fe-S assembly protein IscX D8X09_10695 ENOG4108ZIT Ferredoxin, 2FE-2S D8X09_10700 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB D8X09_10705 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) D8X09_10710 ENOG4108Z4V iron-sulfur cluster assembly D8X09_10715 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins D8X09_10720 ENOG4105C3J Cysteine desulfurase D8X09_10725 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D8X09_10735 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D8X09_10740 ENOG4105CGF Aromatic amino acid aminotransferase D8X09_10745 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D8X09_10775 ENOG4107QNJ CoA-transferase subunit B D8X09_10795 ENOG4105CHR reductase D8X09_10810 ENOG4108UKI Enoyl-CoA hydratase D8X09_10820 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D8X09_10825 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_10830 ENOG4105CN8 Transcriptional regulator D8X09_10835 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D8X09_10840 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D8X09_10845 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D8X09_10850 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D8X09_10855 ENOG4108TEB UPF0114 protein D8X09_10860 ENOG4105VEQ Cold shock protein D8X09_10870 ENOG4105VEQ Cold shock protein D8X09_10905 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D8X09_10910 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D8X09_10915 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) D8X09_10920 ENOG4105C5H ABC transporter D8X09_10925 ENOG4105PE1 Receptor D8X09_10930 ENOG4105C4R Atp-dependent dna helicase D8X09_10950 ENOG4108V3E phosphoribosylglycinamide formyltransferase D8X09_10955 ENOG4105DTN riboflavin biosynthesis protein ribF D8X09_10960 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D8X09_10965 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D8X09_10970 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D8X09_11000 ENOG4105CVE Lytic murein transglycosylase D8X09_11005 ENOG4105ED9 Protein of unknown function (DUF455) D8X09_11025 ENOG4107RRY Cyanophycin synthetase D8X09_11030 ENOG4105D9M gamma-glutamylcysteine synthetase D8X09_11035 ENOG4105VDW Csbd family D8X09_11045 ENOG4105K3G Periplasmic Protein D8X09_11070 ENOG4108I0Y (ABC) transporter D8X09_11075 ENOG4108UJV acyl-CoA thioesterase i D8X09_11080 ENOG4105EIN peptidylprolyl cis-trans isomerase D8X09_11085 ENOG4107T6V glycerophosphoryl diester phosphodiesterase D8X09_11090 ENOG4105D6S protein involved in catabolism of external DNA D8X09_11100 ENOG4105EHV domain protein D8X09_11115 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D8X09_11135 ENOG4108K5P (LipO)protein D8X09_11140 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D8X09_11145 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) D8X09_11150 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D8X09_11160 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D8X09_11165 ENOG4105C7N Xanthine uracil vitamin C permease D8X09_11175 ENOG41080RH Thioredoxin D8X09_11205 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D8X09_11245 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D8X09_11250 ENOG41083UI stage II sporulation protein D8X09_11255 ENOG4105JGF anti-sigma regulatory factor serine threonine protein kinase D8X09_11260 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D8X09_11295 ENOG4105EMN RNA polymerase sigma factor D8X09_11455 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D8X09_11460 ENOG4105C8Q Methyl-accepting chemotaxis D8X09_11465 ENOG4105C2W permease D8X09_11495 ENOG4108KAZ Involved in phosphonate degradation (By similarity) D8X09_11505 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D8X09_11510 ENOG4105DUM transcriptional regulator, lysR family D8X09_11520 ENOG4105KHC sulfurtransferase D8X09_11530 ENOG4105D0M Protease HtpX homolog D8X09_11535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D8X09_11540 ENOG4106UX7 integral membrane protein D8X09_11550 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes D8X09_11560 ENOG4105CW7 secretion protein, HlyD family D8X09_11565 ENOG4105C0R drug resistance transporter emrb qaca subfamily D8X09_11570 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D8X09_11580 ENOG4105DEF Extracellular solute-binding protein, family 5 D8X09_11590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D8X09_11605 ENOG4108JPW Aminotransferase D8X09_11610 ENOG4105K8K Cupin 2, conserved barrel D8X09_11620 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D8X09_11630 ENOG4105C26 Dehydrogenase D8X09_11640 ENOG4105C8Y Acetylornithine aminotransferase D8X09_11645 ENOG4105BZG amino acid carrier protein D8X09_11650 ENOG4105D7A ATP-binding protein D8X09_11655 ENOG4105CDY transcriptional regulatory protein D8X09_11660 ENOG4105C12 Phosphoribosylglycinamide synthetase D8X09_11665 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D8X09_11670 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) D8X09_11675 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D8X09_11680 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D8X09_11685 ENOG4108Z03 MAF-like protein D8X09_11690 ENOG4108P8G outer membrane autotransporter barrel D8X09_11730 ENOG4105C03 ribonuclease D8X09_11735 ENOG4105CQC Prephenate dehydratase D8X09_11750 ENOG4105BZ1 (ABC) transporter D8X09_11755 ENOG4105XA0 heptosyltransferase ii D8X09_11765 ENOG4105KRS Proteinase inhibitor D8X09_11780 ENOG4105DIJ Phosphoethanolamine transferase D8X09_11785 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D8X09_11790 ENOG4106WTF Glycosyl transferase, family 2 D8X09_11795 ENOG4107BJW polysaccharide deacetylase D8X09_11800 ENOG4105CPK Glycosyl transferase (Group 1 D8X09_11805 ENOG4105C0B DNA polymerase III (alpha subunit) D8X09_11815 ENOG4105CQ7 ATP-dependent helicase D8X09_11820 ENOG4108EKC n-acetylglutamate synthase D8X09_11825 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) D8X09_11830 ENOG4105HSS phospholipase C D8X09_11835 ENOG4108UTW Plays a role in the regulation of phosphate uptake D8X09_11840 ENOG4105E66 phosphoriboisomerase A D8X09_11845 ENOG4105CSU acyl-Coa dehydrogenase D8X09_11860 ENOG4108RB4 3-methyladenine DNA glycosylase D8X09_11870 ENOG4105D38 putrescine abc transporter D8X09_11875 ENOG4105F38 ABC transporter, permease D8X09_11880 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D8X09_11885 ENOG4107RUE extracellular solute-binding protein family 1 D8X09_11890 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) D8X09_11900 ENOG4105CV6 ABC transporter, permease D8X09_11905 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D8X09_11915 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_11930 ENOG4105BZN citrate synthase D8X09_11935 ENOG41060IS Flavinator of succinate dehydrogenase D8X09_11940 ENOG4105E33 succinate dehydrogenase D8X09_11950 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein D8X09_11955 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit D8X09_11960 ENOG4105FDP GntR family transcriptional regulator D8X09_11965 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D8X09_11975 ENOG4105BZN citrate synthase D8X09_11980 ENOG4108I0Z Aconitate hydratase D8X09_11985 ENOG4105C7F AcnD-accessory protein PrpF D8X09_11990 ENOG4105DXD 2-methylcitrate dehydratase D8X09_11995 ENOG4108YXA Membrane D8X09_12000 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D8X09_12020 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D8X09_12030 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D8X09_12060 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D8X09_12065 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D8X09_12080 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D8X09_12105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D8X09_12115 ENOG4105DEF Extracellular solute-binding protein, family 5 D8X09_12120 ENOG4108JQ6 ABC transporter D8X09_12125 ENOG4105D44 asparaginase D8X09_12150 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D8X09_12155 ENOG4105CMR udp-glucose 4-epimerase D8X09_12170 ENOG4105C5W Aldolase D8X09_12175 ENOG4108Q5Y Membrane D8X09_12180 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D8X09_12190 ENOG4108ZJF Glcg protein D8X09_12200 ENOG4105K4H Nlp p60 protein D8X09_12215 ENOG4107R11 Transcriptional regulator D8X09_12220 ENOG4105C26 Dehydrogenase D8X09_12230 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family D8X09_12240 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D8X09_12245 ENOG4105MYG DNA polymerase iii, chi subunit D8X09_12255 ENOG4108MN8 Membrane D8X09_12275 ENOG4105C6T cysteine synthase D8X09_12285 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) D8X09_12290 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D8X09_12295 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D8X09_12300 ENOG4105C3F Signal peptidase i D8X09_12305 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D8X09_12310 ENOG4105C0H protease D8X09_12325 ENOG4105EMN RNA polymerase sigma factor D8X09_12335 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D8X09_12340 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D8X09_12345 ENOG4105CHR reductase D8X09_12350 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D8X09_12355 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D8X09_12360 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D8X09_12365 ENOG4105VGS 50s ribosomal protein l32 D8X09_12370 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein D8X09_12375 ENOG4108UHJ MAF-like protein D8X09_12385 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D8X09_12400 ENOG4105D1Q UPF0246 protein D8X09_12410 ENOG4105DTD Dehydrogenase D8X09_12415 ENOG4105CKD glutathione-regulated potassium-efflux system protein D8X09_12455 ENOG4108RWP Major Facilitator Superfamily protein D8X09_12460 ENOG4105CNM Receptor D8X09_12475 ENOG4105BZU Histidine kinase D8X09_12500 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D8X09_12505 ENOG4105D1H recombination factor protein RarA D8X09_12510 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) D8X09_12515 ENOG4105CNU cell division protein FtsK D8X09_12520 ENOG4105C3M thioredoxin reductase D8X09_12525 ENOG4105C98 muts2 protein D8X09_12540 ENOG4107QN1 sodium solute D8X09_12555 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D8X09_12560 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D8X09_12565 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) D8X09_12575 ENOG4105EEX Two component transcriptional regulator (Winged helix family D8X09_12620 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D8X09_12650 ENOG4105CFG Acts as a chaperone (By similarity) D8X09_12660 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D8X09_12670 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D8X09_12675 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) D8X09_12680 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D8X09_12685 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D8X09_12690 ENOG41090R7 Ferric uptake D8X09_12695 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D8X09_12700 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D8X09_12705 ENOG4105D4A Cell wall formation (By similarity) D8X09_12740 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D8X09_12745 ENOG4105WIU sarcosine oxidase delta subunit D8X09_12750 ENOG4105DDR sarcosine oxidase (Beta subunit) D8X09_12760 ENOG4108M0I Transcriptional regulator D8X09_12765 ENOG4105DG4 malate L-lactate dehydrogenase D8X09_12770 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D8X09_12835 ENOG4105F0N pyrophosphate phospho-hydrolase D8X09_12855 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D8X09_12860 ENOG4108ZCF integral membrane protein D8X09_12865 ENOG4108ZCF integral membrane protein D8X09_12870 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D8X09_12875 ENOG4105CMV Succinyl-CoA synthetase subunit beta D8X09_12885 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D8X09_12890 ENOG4105DZ2 Transcriptional regulator D8X09_12895 ENOG4108004 Modulates RecA activity (By similarity) D8X09_12900 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D8X09_12910 ENOG4105DHQ Histidine kinase D8X09_12915 ENOG4105CSH Transporter D8X09_12920 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D8X09_12925 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D8X09_12930 ENOG4107RCV ABC transporter, permease D8X09_12940 ENOG4105CHR reductase D8X09_12960 ENOG4105ETT transcriptional Regulator, LysR family D8X09_12965 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_12975 ENOG4105DH7 May be involved in recombination (By similarity) D8X09_12980 ENOG4105CXT aspartate transcarbamylase D8X09_13045 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D8X09_13050 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D8X09_13055 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D8X09_13060 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D8X09_13065 ENOG4105VJV 50s ribosomal protein L35 D8X09_13080 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D8X09_13090 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D8X09_13105 ENOG4106R49 Methyltransferase D8X09_13120 ENOG4108KF1 Membrane D8X09_13150 ENOG4107KJX Transcriptional regulator D8X09_13155 ENOG4108JQ6 ABC transporter D8X09_13160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D8X09_13170 ENOG4105DEF Extracellular solute-binding protein, family 5 D8X09_13205 ENOG4105DXI Major Facilitator superfamily D8X09_13225 ENOG4105ETT transcriptional Regulator, LysR family D8X09_13230 ENOG4105ECQ AraC Family Transcriptional Regulator D8X09_13235 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein D8X09_13255 ENOG4105CY0 Metallo-Beta-Lactamase D8X09_13290 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D8X09_13305 ENOG4105CI2 imidazolone-5-propionate hydrolase D8X09_13330 ENOG4105CAF HipA N-terminal domain protein D8X09_13345 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D8X09_13350 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D8X09_13390 ENOG4107RH8 nuclease SbcCD subunit D D8X09_13395 ENOG4105MWK D-amino acid dehydrogenase, small subunit D8X09_13400 ENOG4105EW9 transcriptional regulator AsnC family D8X09_13425 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component D8X09_13435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D8X09_13440 ENOG4105E98 transcriptional regulator DeoR family D8X09_13495 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D8X09_13515 ENOG4108YZN class I peptide chain release factor D8X09_13520 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D8X09_13530 ENOG4105CH5 extracellular solute-binding protein, family 7 D8X09_13535 ENOG4108S8N class II Aldolase D8X09_13565 ENOG4108QZZ filamentous hemagglutinin D8X09_13570 ENOG4108ETH Formylglycinamide ribotide synthetase D8X09_13575 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter D8X09_13580 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_13585 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D8X09_13615 ENOG4108ZJI phenylacetic acid degradation protein D8X09_13620 ENOG4108UKI Enoyl-CoA hydratase D8X09_13645 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit D8X09_13650 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit D8X09_13655 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit D8X09_13660 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit D8X09_13665 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein D8X09_13675 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) D8X09_13680 ENOG4105D0M Protease HtpX homolog D8X09_13685 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) D8X09_13700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D8X09_13705 ENOG4105DEF Extracellular solute-binding protein, family 5 D8X09_13710 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D8X09_13715 ENOG4105DUM transcriptional regulator, lysR family D8X09_13740 ENOG4108YZA Nitrogen regulatory protein pii D8X09_13750 ENOG4105CUY Mechanosensitive ion channel D8X09_13755 ENOG4105CH7 arginosuccinase D8X09_13775 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D8X09_13780 ENOG4105CVM Molybdenum cofactor synthesis domain protein D8X09_13785 ENOG4108RIR Molybdenum cofactor biosynthesis protein D8X09_13790 ENOG4108ZAF Molybdopterin D8X09_13800 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D8X09_13810 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) D8X09_13830 ENOG4108TZV Membrane D8X09_13835 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D8X09_13860 ENOG4105W1Y Transcriptional regulator D8X09_13880 ENOG4105CHR reductase D8X09_13890 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) D8X09_13895 ENOG4105CCU oxidase (Subunit III) D8X09_13900 ENOG4105BZ9 Cytochrome C oxidase, subunit I D8X09_13910 ENOG4105CSH Transporter D8X09_13925 ENOG4105W0Z cytoplasmic protein D8X09_13930 ENOG4108YZA Nitrogen regulatory protein pii D8X09_13945 ENOG41060BG Tetr family transcriptional regulator D8X09_13950 ENOG4105DCM major facilitator superfamily D8X09_13955 ENOG4108IV0 ABC, transporter D8X09_13960 ENOG4105C0Z ABC transporter D8X09_13965 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D8X09_13970 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_13985 ENOG4105C26 Dehydrogenase D8X09_13995 ENOG4105DY2 Paraquat-inducible protein b D8X09_14000 ENOG4105F1S paraquat-inducible protein a D8X09_14005 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D8X09_14010 ENOG4108JQB penicillin-binding protein 1C D8X09_14020 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) D8X09_14025 ENOG4105VEQ Cold shock protein D8X09_14035 ENOG4105CHU acetyl-coa acetyltransferase D8X09_14045 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D8X09_14050 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D8X09_14065 ENOG4109015 Biopolymer transport protein exbD tolR D8X09_14070 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D8X09_14075 ENOG4105W49 UPF0434 protein D8X09_14080 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D8X09_14085 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D8X09_14095 ENOG4105CJR Integral membrane protein (MviN D8X09_14105 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) D8X09_14140 ENOG4105DG4 malate L-lactate dehydrogenase D8X09_14160 ENOG4105D6E homoserine dehydrogenase D8X09_14165 ENOG4105CHM Aminotransferase D8X09_14170 ENOG4108UIV Protein of unknown function (DUF498/DUF598) D8X09_14175 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D8X09_14180 ENOG4108IAB Phoh family D8X09_14185 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D8X09_14190 ENOG4105DHU Bile acid D8X09_14195 ENOG4105CDU Replicative dna helicase D8X09_14205 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D8X09_14210 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D8X09_14220 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D8X09_14225 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) D8X09_14230 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D8X09_14235 ENOG4105CTB Polyprenyl synthetase D8X09_14240 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D8X09_14270 ENOG4105CJW magnesium transporter D8X09_14275 ENOG4105NAU thioesterase Superfamily protein D8X09_14280 ENOG4105HMI Membrane D8X09_14285 ENOG4105DUM transcriptional regulator, lysR family D8X09_14290 ENOG4105CH2 amidohydrolase D8X09_14295 ENOG4105CEY Amp-dependent synthetase and ligase D8X09_14310 ENOG4105ECY inositol monophosphatase D8X09_14320 ENOG4105CJQ hydrolase, family 31 D8X09_14325 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D8X09_14330 ENOG4108UMI ABC transporter, permease D8X09_14335 ENOG4105D01 (LipO)protein D8X09_14350 ENOG4105C0A alcohol dehydrogenase D8X09_14380 ENOG41073TP transcriptional regulator D8X09_14405 ENOG4105D56 permease protein D8X09_14410 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component D8X09_14415 ENOG4108IJ9 (ABC) transporter D8X09_14430 ENOG4105WEM extracellular solute-binding protein D8X09_14445 ENOG4108Z4X TRANSCRIPTIONal D8X09_14450 ENOG4108R3E Dna-3-methyladenine glycosylase i D8X09_14455 ENOG41066T0 asmA family D8X09_14465 ENOG4108XFH Transcriptional regulator D8X09_14470 ENOG4105F6U Short-chain dehydrogenase reductase Sdr D8X09_14530 ENOG4105DND Transcriptional regulator D8X09_14535 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D8X09_14540 ENOG4108Z9W Outer membrane porin D8X09_14555 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D8X09_14560 ENOG4105CSH Transporter D8X09_14570 ENOG4106NZI LysR family Transcriptional regulator D8X09_14575 ENOG4105CGF Aromatic amino acid aminotransferase D8X09_14580 ENOG4105EST Metal Dependent Phosphohydrolase D8X09_14605 ENOG4105CPQ Dehydrogenase D8X09_14625 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component D8X09_14635 ENOG4105CEY Amp-dependent synthetase and ligase D8X09_14645 ENOG4108XM1 transcriptional regulator AsnC family D8X09_14655 ENOG4108R6K riboflavin synthase, subunit alpha D8X09_14660 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_14680 ENOG4105DJ2 Major Facilitator Superfamily D8X09_14685 ENOG4107Y2X deaminase D8X09_14695 ENOG4105HEI LysR family (Transcriptional regulator D8X09_14715 ENOG4108IV0 ABC, transporter D8X09_14730 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_14735 ENOG4107Z5Z endoribonuclease L-PSP D8X09_14750 ENOG41069M3 Transcriptional regulator D8X09_14755 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D8X09_14785 ENOG4105E39 Enoyl-CoA hydratase D8X09_14790 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_14795 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_14835 ENOG4105T86 cytochrome C D8X09_14840 ENOG4107QTF adenylosuccinate lyase D8X09_14845 ENOG4108U78 Glutathione S-transferase D8X09_14855 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D8X09_14860 ENOG4105ETT transcriptional Regulator, LysR family D8X09_14875 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D8X09_14885 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D8X09_14895 ENOG4107RNH Outer membrane receptor FepA D8X09_14900 ENOG4105NIV Esterase D8X09_14905 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D8X09_14910 ENOG4105EU8 FAD linked oxidase domain protein D8X09_14915 ENOG4105CQB FAD linked oxidase domain protein D8X09_14920 ENOG4105CQB FAD linked oxidase domain protein D8X09_14925 ENOG4108QZZ filamentous hemagglutinin D8X09_14925 ENOG4108QZZ filamentous hemagglutinin D8X09_14930 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D8X09_14935 ENOG4105D1U peptidase U62 modulator of DNA gyrase D8X09_14985 ENOG4108K5P (LipO)protein D8X09_15000 ENOG4105E0K tonB-dependent siderophore receptor D8X09_15015 ENOG4105E18 UPF0276 protein D8X09_15035 ENOG4105YVS arsR family transcriptional regulator D8X09_15040 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) D8X09_15045 ENOG4105CCU oxidase (Subunit III) D8X09_15050 ENOG4105BZ9 Cytochrome C oxidase, subunit I D8X09_15055 ENOG4105E2S oxidase) subunit II D8X09_15060 ENOG4108UYB regulatoR D8X09_15075 ENOG4105EUB pirin domain protein D8X09_15100 ENOG4105C5Q Transcriptional regulator D8X09_15135 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D8X09_15150 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D8X09_15155 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D8X09_15165 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D8X09_15180 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) D8X09_15185 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D8X09_15195 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D8X09_15200 ENOG4108UJD 30S ribosomal protein S9 D8X09_15205 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D8X09_15210 ENOG4105CH5 extracellular solute-binding protein, family 7 D8X09_15215 ENOG4105CMS peptidase U62, modulator of DNA gyrase D8X09_15220 ENOG4105N42 UPF0307 protein D8X09_15240 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component D8X09_15245 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) D8X09_15250 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase D8X09_15255 ENOG4105C1J atp-dependent rna helicase D8X09_15265 ENOG4105DRR Transcriptional regulator, GntR family D8X09_15280 ENOG4105CD5 CoA-binding domain protein D8X09_15285 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D8X09_15300 ENOG4108YXU transcriptional regulator AsnC family D8X09_15315 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D8X09_15320 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D8X09_15335 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) D8X09_15340 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein D8X09_15380 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D8X09_15385 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D8X09_15390 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D8X09_15395 ENOG4107QX9 Thiol disulfide interChange protein D8X09_15400 ENOG4105DFU Cell wall formation (By similarity) D8X09_15405 ENOG4105IPS esterase D8X09_15420 ENOG4105E2X shikimate dehydrogenase D8X09_15440 ENOG4108XM1 transcriptional regulator AsnC family D8X09_15445 ENOG4105MWK D-amino acid dehydrogenase, small subunit D8X09_15450 ENOG4105CHR reductase D8X09_15470 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D8X09_15475 ENOG4105DR5 peptidase D8X09_15485 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D8X09_15490 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D8X09_15495 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D8X09_15500 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) D8X09_15505 ENOG4105CPF Cell wall formation (By similarity) D8X09_15510 ENOG4105DFU Cell wall formation (By similarity) D8X09_15515 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D8X09_15525 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D8X09_15530 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D8X09_15535 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D8X09_15540 ENOG4105CJN penicillin-binding protein D8X09_15545 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D8X09_15550 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D8X09_15555 ENOG4108V6E Cell division protein mraZ D8X09_15565 ENOG4105C5H ABC transporter D8X09_15570 ENOG4105EKE dihydroorotase D8X09_15575 ENOG4105CH2 amidohydrolase D8X09_15615 ENOG4105EW9 transcriptional regulator AsnC family D8X09_15620 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase D8X09_15625 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D8X09_15630 ENOG4105W2Z cytochrome C, class I D8X09_15635 ENOG4105C01 Dihydroxy-acid dehydratase D8X09_15640 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) D8X09_15690 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D8X09_15695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D8X09_15710 ENOG4108WBT adenosyltransferase D8X09_15725 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D8X09_15730 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D8X09_15735 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D8X09_15740 ENOG4105CKI cobalamin synthesis protein D8X09_15745 ENOG4105MYN Zinc uptake regulation protein D8X09_15755 ENOG4105DIK (ABC) transporter D8X09_15760 ENOG4105CC5 ABC transporter D8X09_15765 ENOG4105DSE periplasmic solute binding protein D8X09_15775 ENOG4105D7X high-affinity nickel-transporter D8X09_15780 ENOG4105UGU tonB-dependent Receptor D8X09_15785 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D8X09_15795 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D8X09_15800 ENOG4105D1S lipid A biosynthesis D8X09_15810 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D8X09_15820 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D8X09_15825 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) D8X09_15830 ENOG41086DT Membrane protein of unknown function D8X09_15835 ENOG4105SYT Methylenetetrahydrofolate reductase D8X09_15845 ENOG4105DUM transcriptional regulator, lysR family D8X09_15855 ENOG4105CSH Transporter D8X09_15865 ENOG4107SC1 transglycosylase D8X09_15870 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D8X09_15880 ENOG4105C1J atp-dependent rna helicase D8X09_15885 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) D8X09_15895 ENOG4107RZC phospholipase d D8X09_15900 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) D8X09_15905 ENOG4105E0C molybdate abc transporter D8X09_15910 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D8X09_15965 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D8X09_15975 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D8X09_15985 ENOG4105CJP fad dependent oxidoreductase D8X09_16015 ENOG4108W9H Tetr family transcriptional regulator D8X09_16030 ENOG4108KXV response regulator D8X09_16080 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D8X09_16105 ENOG4105DFP Integrase D8X09_16110 ENOG4105C3G gtp-binding protein D8X09_16120 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D8X09_16125 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D8X09_16130 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D8X09_16140 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D8X09_16145 ENOG41081V9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) D8X09_16150 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein D8X09_16155 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D8X09_16180 ENOG4105F1J Homogentisate 1,2-dioxygenase D8X09_16190 ENOG4105E0M Sulfatase D8X09_16195 ENOG4105DHQ Histidine kinase D8X09_16200 ENOG4105XJC Two component transcriptional regulator (Winged helix family D8X09_16205 ENOG4105CQB FAD linked oxidase domain protein D8X09_16220 ENOG4107QP8 phosphohexose isomerase D8X09_16225 ENOG4105CGN Glycosyl transferase (Group 1 D8X09_16230 ENOG4108KMV Glycosyl transferase (Group 1 D8X09_16235 ENOG4107XU6 Glycosyl transferase (Group 1 D8X09_16245 ENOG4105CG5 Glycosyl transferase (Group 1 D8X09_16260 ENOG4107QQG Dehydrogenase D8X09_16265 ENOG4107UKG Glycosyl transferase, family 4 D8X09_16270 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) D8X09_16280 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) D8X09_16290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D8X09_16295 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D8X09_16335 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) D8X09_16340 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) D8X09_16350 ENOG4105CQM Urea amidohydrolase subunit alpha D8X09_16355 ENOG4105KI2 Urea amidohydrolase subunit beta D8X09_16365 ENOG4108YZ9 Urea amidohydrolase subunit gamma D8X09_16370 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) D8X09_16395 ENOG4108TZY GntR Family Transcriptional Regulator D8X09_16420 ENOG4105ED1 spovr family D8X09_16425 ENOG4106AKX UPF0229 protein D8X09_16445 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_16450 ENOG4105DZS Phenylacetate-CoA ligase D8X09_16460 ENOG4105C1G acyl-Coa dehydrogenase D8X09_16470 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_16475 ENOG4108IV0 ABC, transporter D8X09_16480 ENOG4105C0Z ABC transporter D8X09_16495 ENOG4105E39 Enoyl-CoA hydratase D8X09_16560 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D8X09_16565 ENOG4105D1A Methyltransferase D8X09_16570 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D8X09_16575 ENOG4105E9H Lytic Murein transglycosylase D8X09_16580 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D8X09_16595 ENOG4108Q2J Inner membrane protein YebE D8X09_16615 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D8X09_16630 ENOG4105C4M (Ubiquinol oxidase) subunit I D8X09_16635 ENOG4105CX6 glutaminyL-tRNA synthetase D8X09_16640 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D8X09_16645 ENOG4107QMS site-determining protein D8X09_16650 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) D8X09_16695 ENOG4108SHN Glycosyl transferase, family 2 D8X09_16710 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D8X09_16740 ENOG4105CEY Amp-dependent synthetase and ligase D8X09_16745 ENOG4105FDP GntR family transcriptional regulator D8X09_16750 ENOG4105CUZ uba thif-type nad fad binding protein D8X09_16765 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D8X09_16785 ENOG4107RSM transcriptional regulator D8X09_16810 ENOG4105DK0 Indole-3-glycerol phosphate synthase D8X09_16815 ENOG4108I0Q anthranilate phosphoribosyltransferase D8X09_16820 ENOG4105DDQ anthranilate synthase D8X09_16830 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D8X09_16840 ENOG4105NWN ApaG protein D8X09_16845 ENOG4105CA3 membrane-bound lytic murein transglycosylase D8X09_16850 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D8X09_16855 ENOG4105T95 Thiol disulfide interChange protein D8X09_16870 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) D8X09_16880 ENOG4108JU3 Alkyl hydroperoxide reductase D8X09_16885 ENOG4105C0H protease D8X09_16890 ENOG4105E39 Enoyl-CoA hydratase D8X09_16915 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) D8X09_16920 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D8X09_16925 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D8X09_16930 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D8X09_16935 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D8X09_16940 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D8X09_16945 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D8X09_16950 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D8X09_16960 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D8X09_16965 ENOG4105C25 Primosomal protein n' D8X09_16970 ENOG4105C4R Atp-dependent dna helicase D8X09_16980 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) D8X09_16990 ENOG4108JQ6 ABC transporter D8X09_16995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D8X09_17000 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D8X09_17020 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D8X09_17025 ENOG41060WC Enoyl-CoA hydratase D8X09_17030 ENOG4105E39 Enoyl-CoA hydratase D8X09_17085 ENOG4105E3B Multicopper oxidase D8X09_17095 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D8X09_17105 ENOG41069M3 Transcriptional regulator D8X09_17110 ENOG4108T2C cysteine dioxygenase type I D8X09_17115 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_17145 ENOG4105DZQ phospholipase D Transphosphatidylase D8X09_17150 ENOG4105X23 Endonuclease Exonuclease phosphatase D8X09_17155 ENOG4105C9M aspartyl-trna synthetase D8X09_17190 ENOG4108EF9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR D8X09_17195 ENOG4105C2X Arabinose 5-phosphate isomerase D8X09_17215 ENOG4108IUZ ABC transporter D8X09_17225 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D8X09_17230 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) D8X09_17235 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding D8X09_17250 ENOG4105K6T rare lipoprotein A D8X09_17280 ENOG4107BVJ 4,5-dihydroxyphthalate decarboxylase D8X09_17290 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D8X09_17300 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D8X09_17305 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D8X09_17310 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D8X09_17350 ENOG4105CD5 CoA-binding domain protein D8X09_17360 ENOG4105CSU acyl-Coa dehydrogenase D8X09_17370 ENOG4105CHU acetyl-coa acetyltransferase D8X09_17380 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D8X09_17405 ENOG4105CD5 CoA-binding domain protein D8X09_17415 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D8X09_17425 ENOG4105KME endoribonuclease L-psp D8X09_17435 ENOG4105CWC Acetylornithine deacetylase D8X09_17445 ENOG4105CC9 acyl-Coa dehydrogenase D8X09_17450 ENOG4105C1G acyl-Coa dehydrogenase D8X09_17455 ENOG4105CXG d-lactate dehydrogenase D8X09_17490 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D8X09_17510 ENOG4105C1G acyl-Coa dehydrogenase D8X09_17530 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D8X09_17535 ENOG4108UKI Enoyl-CoA hydratase D8X09_17540 ENOG4105C1G acyl-Coa dehydrogenase D8X09_17560 ENOG4107RUY (E1 component), alpha subunit D8X09_17565 ENOG4105CPP Dehydrogenase, E1 component D8X09_17570 ENOG4105E39 Enoyl-CoA hydratase D8X09_17575 ENOG4105C7S Dehydrogenase D8X09_17595 ENOG41083Z3 extracellular ligand-binding receptor D8X09_17600 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_17605 ENOG4105C0Z ABC transporter D8X09_17610 ENOG4108IV0 ABC, transporter D8X09_17615 ENOG4107QN2 dihydrolipoyl dehydrogenase D8X09_17655 ENOG4105D06 uba thif-type nad fad binding protein D8X09_17660 ENOG4105CN1 protease D8X09_17665 ENOG41063SB peptidase D8X09_17670 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D8X09_17675 ENOG4105C72 UPF0176 protein D8X09_17680 ENOG4105VW4 glutaredoxin 3 D8X09_17685 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) D8X09_17690 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D8X09_17710 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D8X09_17715 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) D8X09_17720 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D8X09_17730 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D8X09_17760 ENOG4105CH5 extracellular solute-binding protein, family 7 D8X09_17785 ENOG4108UAU isochorismatase D8X09_17800 ENOG4105RE0 Asp Glu hydantoin racemase D8X09_17825 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D8X09_17830 ENOG4105C1A potassium transporter peripheral membrane D8X09_17835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D8X09_17840 ENOG4105ES5 Histidine kinase D8X09_17850 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D8X09_17895 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) D8X09_17915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D8X09_17920 ENOG4107QXX ABC transporter D8X09_17930 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D8X09_17935 ENOG4105C79 DNA protecting protein DprA D8X09_17940 ENOG4105F7P transcriptional regulator AsnC family D8X09_17950 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D8X09_17965 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D8X09_17975 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 D8X09_17985 ENOG4108URH decarboxylase D8X09_18000 ENOG41084KP 4-oxalocrotonate tautomerase D8X09_18005 ENOG4105CJP fad dependent oxidoreductase D8X09_18030 ENOG4105C8Y Acetylornithine aminotransferase D8X09_18055 ENOG4108VUG Enoyl-CoA hydratase D8X09_18060 ENOG4107258 Transcriptional regulator D8X09_18065 ENOG4105CEY Amp-dependent synthetase and ligase D8X09_18120 ENOG4105EPW hflc protein D8X09_18130 ENOG4107YYT May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation (By similarity) D8X09_18180 ENOG4108PNI recT protein D8X09_18235 ENOG4105EXG Transcriptional regulator D8X09_18250 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D8X09_18255 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D8X09_18260 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D8X09_18265 ENOG4105VG0 50S ribosomal protein l34 D8X09_18275 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D8X09_18280 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D8X09_18285 ENOG4108FUF Transcriptional regulator, IclR family D8X09_18290 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D8X09_18305 ENOG4105DMF Dehydrogenase D8X09_18355 ENOG4105CHU acetyl-coa acetyltransferase D8X09_18360 ENOG4107QX3 carboxylase D8X09_18375 ENOG4105C8Y Acetylornithine aminotransferase D8X09_18400 ENOG4105X58 receptor D8X09_18405 ENOG4108RPN Protein smg homolog D8X09_18420 ENOG4105C9U ATP-dependent DNA helicase RecQ D8X09_18435 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component D8X09_18440 ENOG4105CHR reductase D8X09_18445 ENOG4105C26 Dehydrogenase D8X09_18455 ENOG4105C7K acetolactate synthase D8X09_18460 ENOG4108YXU transcriptional regulator AsnC family D8X09_18465 ENOG4105FFC UPF0187 protein D8X09_18475 ENOG4107RDF Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D8X09_18490 ENOG4105C3R Methionine synthase D8X09_18495 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D8X09_18500 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D8X09_18505 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D8X09_18510 ENOG4105DWF phosphomethylpyrimidine kinase D8X09_18515 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D8X09_18525 ENOG4105DFG type I secretion outer membrane protein D8X09_18530 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D8X09_18540 ENOG4105IPI Membrane D8X09_18550 ENOG4107SVH Potassium channel protein D8X09_18565 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D8X09_18570 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D8X09_18575 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D8X09_18580 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D8X09_18585 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D8X09_18590 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D8X09_18595 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D8X09_18600 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D8X09_18605 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D8X09_18610 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D8X09_18615 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D8X09_18620 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D8X09_18625 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D8X09_18630 ENOG41084PQ 50s ribosomal protein l29 D8X09_18635 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D8X09_18655 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D8X09_18660 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D8X09_18665 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D8X09_18670 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D8X09_18675 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D8X09_18680 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D8X09_18685 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D8X09_18690 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D8X09_18695 ENOG4105VPB 50S ribosomal protein L30 D8X09_18700 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D8X09_18705 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D8X09_18710 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D8X09_18720 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D8X09_18725 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D8X09_18730 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D8X09_18735 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D8X09_18740 ENOG4108ZT0 50S ribosomal protein l17 D8X09_18745 ENOG4107YU2 histidine triad (hIT) protein D8X09_18750 ENOG4105VF7 tolerance protein D8X09_18755 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D8X09_18765 ENOG4105D52 delta-aminolevulinic acid dehydratase D8X09_18770 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D8X09_18775 ENOG4106RE7 Cytochrome D8X09_18780 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) D8X09_18785 ENOG4105CRE cytochrome C D8X09_18790 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D8X09_18800 ENOG4105XQ6 frataxin-like protein D8X09_18805 ENOG4108JQC penicillin-binding protein 1A D8X09_18815 ENOG4105D49 3-dehydroquinate synthase D8X09_18820 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D8X09_18830 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D8X09_18835 ENOG4107RDB Major Facilitator D8X09_18840 ENOG4108UUM single-stranded DNA-binding protein D8X09_18880 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) D8X09_18885 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D8X09_18890 ENOG4105JNK Glycosyl transferase (Group 1 D8X09_18910 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D8X09_18935 ENOG4107QP3 malate synthase g D8X09_18960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D8X09_18965 ENOG4108ZGC gaf domain protein D8X09_18970 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D8X09_18985 ENOG4109066 lysm domain bon superfamily protein D8X09_18990 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D8X09_19000 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) D8X09_19015 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D8X09_19060 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D8X09_19075 ENOG4105E39 Enoyl-CoA hydratase D8X09_19090 ENOG410846T CoA-transferase family III D8X09_19095 ENOG4108IG5 Transcriptional regulator D8X09_19100 ENOG4105E09 nadh pyrophosphatase D8X09_19135 ENOG4108IV0 ABC, transporter D8X09_19145 ENOG4105C32 Amino acid ABC transporter (Permease) D8X09_19170 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D8X09_19185 ENOG4105C6Y Udp-glucose 6-dehydrogenase D8X09_19190 ENOG4105C0R drug resistance transporter emrb qaca subfamily D8X09_19195 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D8X09_19220 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D8X09_19245 ENOG4107QS1 Cytochrome C Oxidase, Subunit III D8X09_19260 ENOG4105BZ9 Cytochrome C oxidase, subunit I D8X09_19265 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) D8X09_19280 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D8X09_19285 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D8X09_19295 ENOG4105C4W S-formylglutathione hydrolase D8X09_19300 ENOG4107QPD alcohol dehydrogenase D8X09_19320 ENOG4105EIF outer membrane protein W D8X09_19330 ENOG4105DHJ ABC, transporter D8X09_19335 ENOG4105CY3 ABC transporter, permease D8X09_19340 ENOG4107PE3 Mammalian cell entry related domain protein D8X09_19360 ENOG4105E3A (ABC) transporter D8X09_19370 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D8X09_19375 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D8X09_19380 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D8X09_19385 ENOG4105CIH Imidazole acetol-phosphate transaminase D8X09_19390 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D8X09_19395 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D8X09_19400 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase D8X09_19405 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D8X09_19410 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D8X09_19420 ENOG4107YU2 histidine triad (hIT) protein D8X09_19425 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D8X09_19430 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) D8X09_19450 ENOG4106DF6 pertussis toxin subunit 1 D8X09_19485 ENOG4105EJX conjugal transfer ATPase D8X09_19505 ENOG4108PCE TRANSFER protein D8X09_19510 ENOG4105CMA conjugation trbi family protein D8X09_19525 ENOG4108Q5Y Membrane D8X09_19545 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D8X09_19550 ENOG4105DEF Extracellular solute-binding protein, family 5 D8X09_19555 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D8X09_19560 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D8X09_19575 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) D8X09_19610 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D8X09_19615 ENOG4105BZS acriflavin resistance protein D8X09_19630 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) D8X09_19635 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D8X09_19640 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) D8X09_19655 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D8X09_19660 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) D8X09_19670 ENOG4105C0R drug resistance transporter emrb qaca subfamily D8X09_19675 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D8X09_19690 ENOG4105CDA abc transporter atp-binding protein D8X09_19695 ENOG4105DRP amino acid AbC transporter D8X09_19700 ENOG4105EZ7 amino acid ABC transporter D8X09_19705 ENOG4107QXX ABC transporter D8X09_19710 ENOG4105CAK Cell division ATP-binding protein ftsE D8X09_19715 ENOG4105CRP Part of the ABC transporter FtsEX involved in D8X09_19720 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) D8X09_19730 ENOG4105CEN a g-specific adenine glycosylase D8X09_19740 ENOG4105F2W methyltransferase D8X09_19750 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_19755 ENOG410846T CoA-transferase family III D8X09_19770 ENOG4105E39 Enoyl-CoA hydratase D8X09_19785 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D8X09_19790 ENOG4105E39 Enoyl-CoA hydratase D8X09_19795 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D8X09_19810 ENOG4105CH6 catalase D8X09_19815 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D8X09_19830 ENOG4105E2B Taurine dioxygenase D8X09_19835 ENOG4105CH2 amidohydrolase D8X09_19840 ENOG4108JQ7 (ABC) transporter D8X09_19845 ENOG4105C3U ABC transporter D8X09_19855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D8X09_19860 ENOG4105DEF Extracellular solute-binding protein, family 5 D8X09_19865 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D8X09_19880 ENOG41062D9 Histidine kinase D8X09_19900 ENOG4105CHM Aminotransferase