locus-tag	class	description
D8X09_00005	COG0445	tRNA wobble uridine modification
D8X09_00015	COG1192	Involved in chromosome partitioning
D8X09_00025	COG1475	DNA binding
D8X09_00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D8X09_00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D8X09_00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D8X09_00075	COG0081	regulation of translation
D8X09_00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D8X09_00085	COG0222	ribosome binding
D8X09_00090	COG0085	RNA polymerase activity
D8X09_00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D8X09_00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_00160	COG1024	Enoyl-CoA hydratase
D8X09_00180	COG0752	glycyl-tRNA synthetase alpha subunit
D8X09_00185	COG0751	glycine-tRNA ligase activity
D8X09_00190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D8X09_00195	COG0204	Acyl-transferase
D8X09_00210	COG0242	peptide deformylase activity
D8X09_00250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8X09_00255	COG2813	Specifically methylates the guanine in position
D8X09_00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8X09_00270	COG2223	nitrite transmembrane transporter activity
D8X09_00280	COG1794	racemase activity, acting on amino acids and derivatives
D8X09_00285	COG1126	abc transporter atp-binding protein
D8X09_00290	COG0765	amino acid transport
D8X09_00295	COG0765	amino acid transport
D8X09_00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8X09_00395	COG0326	Molecular chaperone. Has ATPase activity
D8X09_00400	COG0625	glutathione transferase activity
D8X09_00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D8X09_00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D8X09_00450	COG0438	transferase activity, transferring glycosyl groups
D8X09_00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D8X09_00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D8X09_00490	COG0859	PFAM glycosyl transferase family 9
D8X09_00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D8X09_00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8X09_00520	COG1127	ABC transporter
D8X09_00540	COG1686	Belongs to the peptidase S11 family
D8X09_00550	COG2921	Belongs to the UPF0250 family
D8X09_00555	COG0321	lipoyl(octanoyl) transferase activity
D8X09_00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D8X09_00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8X09_00605	COG0018	arginyl-trna synthetase
D8X09_00625	COG0395	ABC-type sugar transport system, permease component
D8X09_00630	COG1175	transmembrane transport
D8X09_00635	COG1653	transport
D8X09_00640	COG3842	ATPase activity
D8X09_00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D8X09_00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D8X09_00675	COG1609	Transcriptional regulator
D8X09_00685	COG0154	amidase activity
D8X09_00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8X09_00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D8X09_00710	COG0583	DNA-binding transcription factor activity
D8X09_00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8X09_00745	COG1802	Transcriptional regulator
D8X09_00760	COG1024	Enoyl-CoA hydratase
D8X09_00770	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_00785	COG1984	allophanate hydrolase subunit 2
D8X09_00790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D8X09_00800	COG0583	DNA-binding transcription factor activity
D8X09_00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8X09_00815	COG5002	protein histidine kinase activity
D8X09_00825	COG5002	protein histidine kinase activity
D8X09_00830	COG0745	RESPONSE REGULATOR receiver
D8X09_00835	COG2226	methyltransferase
D8X09_00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D8X09_00870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D8X09_00880	COG0513	Belongs to the DEAD box helicase family
D8X09_00885	COG1280	lysine exporter protein (LysE YggA)
D8X09_00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D8X09_00930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8X09_00930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8X09_00940	COG0489	protein tyrosine kinase activity
D8X09_00955	COG0717	Belongs to the dCTP deaminase family
D8X09_00980	COG1982	Orn Lys Arg decarboxylase major
D8X09_00985	COG2081	HI0933 family
D8X09_00995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D8X09_01005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D8X09_01010	COG0509	glycine decarboxylation via glycine cleavage system
D8X09_01015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D8X09_01015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D8X09_01055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8X09_01070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8X09_01080	COG1414	Transcriptional regulator
D8X09_01085	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_01090	COG2031	fatty acid transporter
D8X09_01095	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8X09_01105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D8X09_01110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D8X09_01120	COG4257	antibiotic catabolic process
D8X09_01145	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_01150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D8X09_01155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8X09_01180	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_01190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8X09_01200	COG2188	Transcriptional regulator
D8X09_01205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8X09_01230	COG0617	tRNA 3'-terminal CCA addition
D8X09_01245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D8X09_01250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D8X09_01255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D8X09_01260	COG0586	Pfam SNARE associated Golgi protein
D8X09_01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
D8X09_01270	COG0802	atpase or kinase
D8X09_01275	COG0114	fumarate hydratase activity
D8X09_01285	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_01295	COG0405	Gamma-glutamyltransferase
D8X09_01300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_01335	COG1294	oxidase, subunit
D8X09_01345	COG4988	ABC transporter
D8X09_01350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D8X09_01355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D8X09_01400	COG2969	positive regulation of protein catabolic process
D8X09_01405	COG0625	glutathione transferase activity
D8X09_01410	COG2857	Cytochrome c1
D8X09_01415	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D8X09_01420	COG0723	plastoquinol--plastocyanin reductase activity
D8X09_01425	COG1970	mechanosensitive ion channel activity
D8X09_01430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D8X09_01445	COG2808	Putative FMN-binding domain
D8X09_01450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8X09_01455	COG0747	negative chemotaxis
D8X09_01460	COG0657	acetylesterase activity
D8X09_01470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8X09_01475	COG2207	Transcriptional regulator
D8X09_01480	COG0129	dihydroxy-acid dehydratase activity
D8X09_01485	COG2814	Major facilitator Superfamily
D8X09_01490	COG0583	DNA-binding transcription factor activity
D8X09_01500	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
D8X09_01540	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_01550	COG0411	ABC transporter
D8X09_01555	COG0410	ABC transporter
D8X09_01570	COG1024	Enoyl-CoA hydratase
D8X09_01575	COG1960	acyl-CoA dehydrogenase activity
D8X09_01600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D8X09_01620	COG1678	Uncharacterized ACR, COG1678
D8X09_01625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D8X09_01630	COG0540	Belongs to the ATCase OTCase family
D8X09_01645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D8X09_01655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8X09_01690	COG1234	tRNA 3'-trailer cleavage
D8X09_01710	COG3064	Membrane
D8X09_01725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8X09_01740	COG1683	Conserved Protein
D8X09_01745	COG1120	ATPase activity
D8X09_01750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8X09_01755	COG4558	Periplasmic binding protein
D8X09_01760	COG3720	iron ion transport
D8X09_01770	COG3712	iron ion homeostasis
D8X09_01775	COG1595	DNA-templated transcription, initiation
D8X09_01810	COG1802	Transcriptional regulator
D8X09_01820	COG3069	C4-dicarboxylate transmembrane transporter activity
D8X09_01830	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_01865	COG2860	membrane
D8X09_01870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8X09_01875	COG0708	Exodeoxyribonuclease III
D8X09_01880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D8X09_01885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8X09_01890	COG0154	amidase activity
D8X09_01895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8X09_01900	COG1077	Cell shape determining protein MreB Mrl
D8X09_01905	COG1792	Involved in formation and maintenance of cell shape
D8X09_01915	COG0768	penicillin binding
D8X09_01920	COG0772	Belongs to the SEDS family
D8X09_01925	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D8X09_01930	COG0471	metal ion transport
D8X09_01935	COG1309	transcriptional regulator
D8X09_01945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D8X09_01960	COG2823	Periplasmic or secreted lipoprotein
D8X09_01965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D8X09_01980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8X09_02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_02010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_02030	COG0492	ferredoxin-NADP+ reductase activity
D8X09_02040	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_02045	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8X09_02045	COG1024	Enoyl-CoA hydratase
D8X09_02050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_02055	COG0028	Belongs to the TPP enzyme family
D8X09_02080	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_02095	COG0697	spore germination
D8X09_02125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D8X09_02130	COG0463	Glycosyl transferase, family 2
D8X09_02145	COG0786	glutamate:sodium symporter activity
D8X09_02155	COG2031	fatty acid transporter
D8X09_02170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D8X09_02185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D8X09_02200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8X09_02210	COG1285	pathogenesis
D8X09_02215	COG1253	flavin adenine dinucleotide binding
D8X09_02220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_02225	COG1024	Enoyl-CoA hydratase
D8X09_02230	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_02235	COG0583	DNA-binding transcription factor activity
D8X09_02240	COG1960	acyl-CoA dehydrogenase activity
D8X09_02250	COG0183	Belongs to the thiolase family
D8X09_02270	COG0583	DNA-binding transcription factor activity
D8X09_02275	COG1278	Cold shock
D8X09_02285	COG1802	Transcriptional regulator
D8X09_02290	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_02295	COG2031	fatty acid transporter
D8X09_02300	COG1017	nitric oxide dioxygenase activity
D8X09_02300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8X09_02305	COG0251	oxidation-reduction process
D8X09_02325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_02335	COG0583	DNA-binding transcription factor activity
D8X09_02340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_02350	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D8X09_02355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D8X09_02360	COG0546	phosphoglycolate phosphatase activity
D8X09_02370	COG1530	ribonuclease E activity
D8X09_02395	COG0159	tryptophan synthase activity
D8X09_02400	COG0133	tryptophan synthase activity
D8X09_02410	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8X09_02415	COG3228	Belongs to the MtfA family
D8X09_02425	COG0251	oxidation-reduction process
D8X09_02430	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D8X09_02435	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D8X09_02450	COG2878	Part of a membrane complex involved in electron transport
D8X09_02455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D8X09_02460	COG0411	ABC transporter
D8X09_02475	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_02490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8X09_02495	COG0411	ABC transporter
D8X09_02510	COG1268	BioY protein
D8X09_02515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D8X09_02520	COG1122	ATPase activity
D8X09_02525	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D8X09_02545	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D8X09_02555	COG1196	nuclear chromosome segregation
D8X09_02560	COG0477	Major facilitator Superfamily
D8X09_02565	COG1573	uracil-dna glycosylase
D8X09_02570	COG1214	PFAM Peptidase M22, glycoprotease
D8X09_02575	COG0745	RESPONSE REGULATOR receiver
D8X09_02585	COG2205	protein histidine kinase activity
D8X09_02590	COG0450	alkyl hydroperoxide reductase
D8X09_02595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8X09_02615	COG2186	Transcriptional regulator
D8X09_02635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D8X09_02645	COG0583	DNA-binding transcription factor activity
D8X09_02655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8X09_02660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D8X09_02665	COG0137	argininosuccinate synthase activity
D8X09_02670	COG3158	transport of potassium into the cell
D8X09_02675	COG0642	Histidine kinase
D8X09_02680	COG0745	RESPONSE REGULATOR receiver
D8X09_02705	COG0776	regulation of translation
D8X09_02710	COG3128	pkhd-type hydroxylase
D8X09_02720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8X09_02725	COG0557	exoribonuclease II activity
D8X09_02745	COG2153	protein acetylation
D8X09_02750	COG0679	Auxin Efflux Carrier
D8X09_02755	COG2391	methyltransferase activity
D8X09_02760	COG0069	glutamate synthase activity
D8X09_02770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8X09_02780	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D8X09_02820	COG3706	GGDEF domain
D8X09_02850	COG0583	DNA-binding transcription factor activity
D8X09_02860	COG1053	succinate dehydrogenase
D8X09_02880	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D8X09_02885	COG0459	protein refolding
D8X09_02890	COG3468	outer membrane autotransporter barrel domain protein
D8X09_02905	COG1252	NADH dehydrogenase
D8X09_02910	COG0284	orotidine-5'-phosphate decarboxylase activity
D8X09_02915	COG1058	Belongs to the CinA family
D8X09_02915	COG1546	Belongs to the CinA family
D8X09_02920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D8X09_02930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8X09_02935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D8X09_02975	COG3639	organic phosphonate transmembrane transporter activity
D8X09_02980	COG3639	organic phosphonate transmembrane transporter activity
D8X09_03000	COG0742	ribosomal rna small subunit methyltransferase
D8X09_03005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D8X09_03010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8X09_03015	COG3135	benzoate transporter
D8X09_03030	COG0640	Transcriptional regulator
D8X09_03060	COG4172	Belongs to the ABC transporter superfamily
D8X09_03065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_03070	COG0601	transmembrane transport
D8X09_03080	COG0281	malic enzyme
D8X09_03080	COG0280	phosphate acetyltransferase
D8X09_03140	COG0583	DNA-binding transcription factor activity
D8X09_03155	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D8X09_03160	COG0167	dihydroorotate dehydrogenase activity
D8X09_03180	COG1414	Transcriptional regulator
D8X09_03185	COG1058	Belongs to the CinA family
D8X09_03185	COG1546	Belongs to the CinA family
D8X09_03205	COG0513	Belongs to the DEAD box helicase family
D8X09_03235	COG0429	hydrolase of the alpha beta-hydrolase fold
D8X09_03240	COG4783	chaperone-mediated protein folding
D8X09_03255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D8X09_03280	COG0006	proline dipeptidase activity
D8X09_03290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8X09_03310	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D8X09_03315	COG0632	four-way junction helicase activity
D8X09_03330	COG2255	four-way junction helicase activity
D8X09_03335	COG0514	ATP-dependent DNA helicase (RecQ)
D8X09_03350	COG0288	reversible hydration of carbon dioxide
D8X09_03355	COG0154	amidase activity
D8X09_03360	COG0683	leucine binding
D8X09_03365	COG4211	Belongs to the binding-protein-dependent transport system permease family
D8X09_03380	COG0410	ABC transporter
D8X09_03395	COG1464	Belongs to the NlpA lipoprotein family
D8X09_03535	COG1196	nuclear chromosome segregation
D8X09_03605	COG2135	peptidase activity
D8X09_03620	COG0494	nUDIX hydrolase
D8X09_03625	COG0442	prolyl-tRNA aminoacylation
D8X09_03630	COG0824	Thioesterase
D8X09_03635	COG0811	peptide transport
D8X09_03640	COG0848	biopolymer transport protein
D8X09_03650	COG0823	Involved in the tonB-independent uptake of proteins
D8X09_03665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8X09_03670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D8X09_03705	COG0700	Nucleoside recognition
D8X09_03710	COG0469	pyruvate kinase activity
D8X09_03715	COG1929	Belongs to the glycerate kinase type-1 family
D8X09_03720	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D8X09_03725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8X09_03730	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D8X09_03740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D8X09_03750	COG2154	pterin-4-alpha-carbinolamine dehydratase
D8X09_03775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8X09_03780	COG0154	amidase activity
D8X09_03790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_03795	COG0601	transmembrane transport
D8X09_03800	COG0747	negative chemotaxis
D8X09_03820	COG0019	diaminopimelate decarboxylase activity
D8X09_03835	COG2353	YceI-like domain
D8X09_03840	COG4774	siderophore transport
D8X09_03845	COG3712	iron ion homeostasis
D8X09_03885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D8X09_03890	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D8X09_03895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D8X09_03900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D8X09_03910	COG0142	geranyltranstransferase activity
D8X09_03920	COG0583	DNA-binding transcription factor activity
D8X09_03930	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
D8X09_03935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_03955	COG2994	toxin metabolic process
D8X09_03965	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D8X09_03970	COG2274	protein secretion by the type I secretion system
D8X09_03975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8X09_03980	COG1538	Outer membrane efflux protein
D8X09_04000	COG0765	amino acid transport
D8X09_04005	COG1126	abc transporter atp-binding protein
D8X09_04025	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_04035	COG1802	Transcriptional regulator
D8X09_04045	COG1802	Transcriptional regulator
D8X09_04055	COG0318	PFAM AMP-dependent synthetase and ligase
D8X09_04065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_04075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8X09_04085	COG0028	Belongs to the TPP enzyme family
D8X09_04105	COG0308	aminopeptidase N
D8X09_04110	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D8X09_04130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D8X09_04135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D8X09_04140	COG0560	Phosphoserine phosphatase
D8X09_04145	COG0583	DNA-binding transcription factor activity
D8X09_04150	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_04155	COG0028	Belongs to the TPP enzyme family
D8X09_04170	COG4774	siderophore transport
D8X09_04175	COG4774	siderophore transport
D8X09_04185	COG1007	ATP synthesis coupled electron transport
D8X09_04200	COG0713	ATP synthesis coupled electron transport
D8X09_04210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8X09_04215	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D8X09_04220	COG1034	ATP synthesis coupled electron transport
D8X09_04230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D8X09_04235	COG0649	NAD binding
D8X09_04240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8X09_04245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8X09_04250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8X09_04255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D8X09_04285	COG0671	phosphoesterase, PA-phosphatase related
D8X09_04295	COG1597	lipid kinase activity
D8X09_04300	COG0583	DNA-binding transcription factor activity
D8X09_04305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8X09_04315	COG1733	regulation of RNA biosynthetic process
D8X09_04320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8X09_04325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8X09_04340	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D8X09_04360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_04380	COG3608	succinylglutamate desuccinylase aspartoacylase
D8X09_04385	COG0626	cystathionine gamma-synthase activity
D8X09_04390	COG0583	DNA-binding transcription factor activity
D8X09_04425	COG3799	methylaspartate ammonia-lyase activity
D8X09_04435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8X09_04445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D8X09_04450	COG0149	triose-phosphate isomerase activity
D8X09_04470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8X09_04490	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D8X09_04505	COG1183	phosphatidylcholine synthase activity
D8X09_04510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D8X09_04515	COG0440	acetolactate synthase activity
D8X09_04520	COG0028	Belongs to the TPP enzyme family
D8X09_04535	COG5265	(ABC) transporter
D8X09_04540	COG0500	methyltransferase
D8X09_04560	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D8X09_04580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D8X09_04590	COG0511	ligase activity, forming carbon-carbon bonds
D8X09_04615	COG2188	Transcriptional regulator
D8X09_04620	COG0439	Biotin carboxylase
D8X09_04670	COG5265	(ABC) transporter
D8X09_04680	COG0667	Aldo Keto reductase
D8X09_04695	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D8X09_04735	COG0583	DNA-binding transcription factor activity
D8X09_04765	COG2814	Major facilitator Superfamily
D8X09_04775	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8X09_04790	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D8X09_04800	COG0287	Prephenate dehydrogenase
D8X09_04805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D8X09_04810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D8X09_04830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D8X09_04835	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D8X09_04840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8X09_04845	COG1555	photosystem II stabilization
D8X09_04845	COG1596	polysaccharide export
D8X09_04860	COG2951	lytic endotransglycosylase activity
D8X09_04865	COG0123	including yeast histone deacetylase and acetoin utilization protein
D8X09_04880	COG1960	acyl-CoA dehydrogenase activity
D8X09_04885	COG0450	alkyl hydroperoxide reductase
D8X09_04905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D8X09_04940	COG0335	large ribosomal subunit rRNA binding
D8X09_04955	COG0667	Aldo Keto reductase
D8X09_04970	COG3161	chorismate lyase activity
D8X09_04975	COG1187	pseudouridine synthase activity
D8X09_04995	COG1538	Outer membrane efflux protein
D8X09_05005	COG1999	signal sequence binding
D8X09_05010	COG0339	signal peptide processing
D8X09_05020	COG4566	intracellular signal transduction
D8X09_05030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D8X09_05035	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8X09_05040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8X09_05045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D8X09_05055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D8X09_05060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D8X09_05065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D8X09_05070	COG0126	phosphoglycerate kinase activity
D8X09_05075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D8X09_05080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D8X09_05095	COG0625	glutathione transferase activity
D8X09_05125	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D8X09_05135	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8X09_05145	COG0739	heme binding
D8X09_05155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D8X09_05165	COG1191	sigma factor activity
D8X09_05195	COG2198	Histidine kinase
D8X09_05195	COG0643	Histidine kinase
D8X09_05200	COG0835	chemotaxis
D8X09_05205	COG0840	transmembrane signaling receptor activity
D8X09_05215	COG2201	protein-glutamate methylesterase activity
D8X09_05220	COG0745	RESPONSE REGULATOR receiver
D8X09_05225	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D8X09_05250	COG0667	Aldo Keto reductase
D8X09_05260	COG4535	Mg2 and Co2 transporter CorC
D8X09_05265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D8X09_05270	COG1702	phosphate starvation-inducible protein PhoH
D8X09_05275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D8X09_05290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8X09_05295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8X09_05300	COG1862	Preprotein translocase
D8X09_05305	COG0343	queuine tRNA-ribosyltransferase activity
D8X09_05310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D8X09_05315	COG2027	D-alanyl-D-alanine carboxypeptidase
D8X09_05320	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D8X09_05330	COG3468	outer membrane autotransporter barrel domain protein
D8X09_05335	COG1648	precorrin-2 dehydrogenase activity
D8X09_05335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D8X09_05360	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D8X09_05365	COG0741	lytic transglycosylase activity
D8X09_05375	COG0436	Aminotransferase
D8X09_05385	COG0281	malic enzyme
D8X09_05385	COG0280	phosphate acetyltransferase
D8X09_05395	COG2732	(Barnase) inhibitor
D8X09_05410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D8X09_05435	COG0248	Ppx GppA phosphatase
D8X09_05445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8X09_05455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8X09_05460	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D8X09_05465	COG1534	Rna-binding protein
D8X09_05495	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D8X09_05510	COG1295	ribonuclease BN
D8X09_05520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D8X09_05525	COG0745	RESPONSE REGULATOR receiver
D8X09_05530	COG2205	protein histidine kinase activity
D8X09_05565	COG1022	Amp-dependent synthetase and ligase
D8X09_05580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D8X09_05585	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_05595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D8X09_05610	COG1136	(ABC) transporter
D8X09_05615	COG0084	hydrolase, TatD family'
D8X09_05640	COG2333	competence protein COMEC
D8X09_05640	COG0658	competence protein
D8X09_05650	COG0613	PHP domain protein
D8X09_05670	COG3539	Fimbrial protein
D8X09_05675	COG0280	phosphate acetyltransferase
D8X09_05675	COG0281	malic enzyme
D8X09_05685	COG1522	sequence-specific DNA binding
D8X09_05695	COG0567	Dehydrogenase, E1 component
D8X09_05700	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8X09_05705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8X09_05710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D8X09_05715	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_05720	COG0583	DNA-binding transcription factor activity
D8X09_05730	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_05755	COG0180	Tryptophanyl-tRNA synthetase
D8X09_05760	COG2183	response to ionizing radiation
D8X09_05765	COG1199	ATP-dependent helicase activity
D8X09_05775	COG0564	pseudouridine synthase activity
D8X09_05785	COG3243	poly(R)-hydroxyalkanoic acid synthase
D8X09_05790	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_05795	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D8X09_05850	COG0583	DNA-binding transcription factor activity
D8X09_05860	COG2814	Major facilitator Superfamily
D8X09_05875	COG1619	proteins homologs of microcin C7 resistance protein MccF
D8X09_05890	COG2084	Dehydrogenase
D8X09_05895	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_05920	COG2988	succinylglutamate desuccinylase activity
D8X09_05950	COG0765	amino acid transport
D8X09_05955	COG0765	amino acid transport
D8X09_05960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_05995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8X09_06000	COG1595	DNA-templated transcription, initiation
D8X09_06010	COG3530	Putative quorum-sensing-regulated virulence factor
D8X09_06015	COG0494	nUDIX hydrolase
D8X09_06030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8X09_06035	COG0542	response to heat
D8X09_06065	COG3468	outer membrane autotransporter barrel domain protein
D8X09_06075	COG5441	Belongs to the UPF0261 family
D8X09_06080	COG5564	TIM-barrel signal transduction protein
D8X09_06095	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D8X09_06110	COG1477	protein flavinylation
D8X09_06130	COG1131	(ABC) transporter
D8X09_06135	COG0842	Transport permease protein
D8X09_06145	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D8X09_06150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D8X09_06150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D8X09_06155	COG1562	ergosterol biosynthetic process
D8X09_06160	COG1562	ergosterol biosynthetic process
D8X09_06165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D8X09_06170	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_06190	COG2304	oxidoreductase activity
D8X09_06210	COG0534	Mate efflux family protein
D8X09_06220	COG0254	rRNA binding
D8X09_06225	COG3483	tryptophan 2,3-dioxygenase activity
D8X09_06230	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D8X09_06235	COG2003	Belongs to the UPF0758 family
D8X09_06240	COG1047	Peptidyl-prolyl cis-trans
D8X09_06250	COG0625	glutathione transferase activity
D8X09_06270	COG0523	cobalamin synthesis protein
D8X09_06280	COG0583	DNA-binding transcription factor activity
D8X09_06290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D8X09_06295	COG1187	pseudouridine synthase activity
D8X09_06300	COG0779	Required for maturation of 30S ribosomal subunits
D8X09_06305	COG2251	uridine kinase activity
D8X09_06305	COG0195	Participates in both transcription termination and antitermination
D8X09_06310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D8X09_06315	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D8X09_06320	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D8X09_06340	COG1611	Belongs to the LOG family
D8X09_06355	COG0412	Dienelactone hydrolase
D8X09_06360	COG1283	sodium-dependent phosphate transmembrane transporter activity
D8X09_06365	COG1760	l-serine dehydratase
D8X09_06370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D8X09_06375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D8X09_06385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D8X09_06395	COG0187	DNA topoisomerase II activity
D8X09_06410	COG2311	Membrane
D8X09_06435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D8X09_06455	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_06470	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D8X09_06480	COG1653	transport
D8X09_06485	COG1175	transmembrane transport
D8X09_06490	COG0395	ABC-type sugar transport system, permease component
D8X09_06495	COG3842	ATPase activity
D8X09_06520	COG2363	Small membrane protein
D8X09_06560	COG0095	Lipoate-protein ligase
D8X09_06575	COG0625	glutathione transferase activity
D8X09_06580	COG0386	Belongs to the glutathione peroxidase family
D8X09_06600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_06630	COG2259	Doxx family
D8X09_06645	COG0667	Aldo Keto reductase
D8X09_06675	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D8X09_06695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D8X09_06705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D8X09_06755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8X09_06760	COG3568	Endonuclease Exonuclease Phosphatase
D8X09_06770	COG1695	Transcriptional regulator
D8X09_06790	COG0583	DNA-binding transcription factor activity
D8X09_06805	COG1802	Transcriptional regulator
D8X09_06815	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_06825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_06840	COG0066	3-isopropylmalate dehydratase activity
D8X09_06850	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_06855	COG4948	Mandelate Racemase Muconate Lactonizing
D8X09_06870	COG1126	abc transporter atp-binding protein
D8X09_06880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_06920	COG1815	bacterial-type flagellum-dependent cell motility
D8X09_06925	COG1558	bacterial-type flagellum-dependent cell motility
D8X09_06930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D8X09_06935	COG1749	Flagellar hook protein flgE
D8X09_06945	COG4786	Flagellar basal body rod
D8X09_06950	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D8X09_06955	COG1706	bacterial-type flagellum-dependent cell motility
D8X09_06965	COG1256	bacterial-type flagellum assembly
D8X09_06975	COG0840	transmembrane signaling receptor activity
D8X09_06980	COG0840	transmembrane signaling receptor activity
D8X09_06985	COG0840	transmembrane signaling receptor activity
D8X09_07005	COG1338	Plays a role in the flagellum-specific transport system
D8X09_07025	COG1580	Controls the rotational direction of flagella during chemotaxis
D8X09_07050	COG1157	protein secretion by the type III secretion system
D8X09_07060	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D8X09_07070	COG1677	Flagellar hook-basal body complex protein FliE
D8X09_07080	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D8X09_07115	COG0285	dihydrofolate synthase activity
D8X09_07145	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D8X09_07150	COG0024	Methionine aminopeptidase
D8X09_07155	COG0052	Belongs to the universal ribosomal protein uS2 family
D8X09_07160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D8X09_07165	COG0528	UMP kinase activity
D8X09_07170	COG0233	cytoplasmic translational termination
D8X09_07175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D8X09_07185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D8X09_07190	COG0750	zinc metalloprotease
D8X09_07195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D8X09_07200	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D8X09_07205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8X09_07210	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D8X09_07220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8X09_07225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D8X09_07230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8X09_07235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D8X09_07245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8X09_07245	COG0519	Catalyzes the synthesis of GMP from XMP
D8X09_07260	COG0330	HflC and HflK could
D8X09_07265	COG3706	GGDEF domain
D8X09_07270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D8X09_07280	COG2867	negative regulation of translational initiation
D8X09_07290	COG1960	acyl-CoA dehydrogenase activity
D8X09_07295	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D8X09_07325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D8X09_07330	COG0505	Belongs to the CarA family
D8X09_07335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D8X09_07345	COG0406	alpha-ribazole phosphatase activity
D8X09_07355	COG3842	ATPase activity
D8X09_07375	COG5001	Diguanylate cyclase
D8X09_07380	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D8X09_07385	COG4783	chaperone-mediated protein folding
D8X09_07390	COG1763	Mo-molybdopterin cofactor biosynthetic process
D8X09_07395	COG0303	'Molybdopterin
D8X09_07400	COG0746	molybdenum cofactor guanylyltransferase activity
D8X09_07405	COG0489	protein tyrosine kinase activity
D8X09_07435	COG0243	molybdopterin cofactor binding
D8X09_07435	COG3383	formate dehydrogenase (NAD+) activity
D8X09_07470	COG1122	ATPase activity
D8X09_07480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D8X09_07485	COG0066	3-isopropylmalate dehydratase activity
D8X09_07490	COG0473	3-isopropylmalate dehydrogenase activity
D8X09_07495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D8X09_07505	COG0101	tRNA pseudouridine synthase activity
D8X09_07510	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8X09_07525	COG0135	phosphoribosylanthranilate isomerase activity
D8X09_07540	COG3022	response to hydroperoxide
D8X09_07560	COG3706	GGDEF domain
D8X09_07580	COG2197	response regulator
D8X09_07585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D8X09_07590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D8X09_07595	COG0189	ligase activity
D8X09_07605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8X09_07610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D8X09_07625	COG2423	ornithine cyclodeaminase activity
D8X09_07635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_07640	COG0765	amino acid transport
D8X09_07645	COG0765	amino acid transport
D8X09_07650	COG1126	abc transporter atp-binding protein
D8X09_07705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D8X09_07715	COG2944	sequence-specific DNA binding
D8X09_07725	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D8X09_07730	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D8X09_07735	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D8X09_07740	COG0009	L-threonylcarbamoyladenylate synthase
D8X09_07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_07750	COG1414	Transcriptional regulator
D8X09_07765	COG0765	amino acid transport
D8X09_07770	COG1126	abc transporter atp-binding protein
D8X09_07775	COG0028	Belongs to the TPP enzyme family
D8X09_07790	COG0028	Belongs to the TPP enzyme family
D8X09_07795	COG0583	DNA-binding transcription factor activity
D8X09_07800	COG4974	Belongs to the 'phage' integrase family
D8X09_07805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D8X09_07810	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D8X09_07825	COG1686	Belongs to the peptidase S11 family
D8X09_07845	COG1074	ATP-dependent DNA helicase activity
D8X09_07855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8X09_07860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D8X09_07865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D8X09_07885	COG2321	neutral zinc metallopeptidase
D8X09_07890	COG0009	L-threonylcarbamoyladenylate synthase
D8X09_07935	COG3360	Dodecin
D8X09_07940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D8X09_07945	COG2850	peptidyl-arginine hydroxylation
D8X09_07950	COG3539	Fimbrial protein
D8X09_07955	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D8X09_07960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8X09_07975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_07980	COG0765	amino acid transport
D8X09_07985	COG1126	abc transporter atp-binding protein
D8X09_07990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8X09_07995	COG1758	RNA polymerase activity
D8X09_08000	COG0194	GDP metabolic process
D8X09_08005	COG3258	Cytochrome c
D8X09_08010	COG2863	cytochrome
D8X09_08015	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_08020	COG0791	NLP P60 protein
D8X09_08025	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D8X09_08045	COG1561	YicC-like family, N-terminal region
D8X09_08050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D8X09_08065	COG0840	transmembrane signaling receptor activity
D8X09_08070	COG2200	EAL domain
D8X09_08070	COG2199	diguanylate cyclase activity
D8X09_08075	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D8X09_08085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D8X09_08095	COG3852	Histidine kinase
D8X09_08100	COG2204	response regulator
D8X09_08105	COG0583	DNA-binding transcription factor activity
D8X09_08110	COG1741	Belongs to the pirin family
D8X09_08115	COG1741	Belongs to the pirin family
D8X09_08125	COG3842	ATPase activity
D8X09_08130	COG1178	ABC-type Fe3 transport system permease component
D8X09_08135	COG1840	ABC-type Fe3 transport system, periplasmic component
D8X09_08145	COG0583	DNA-binding transcription factor activity
D8X09_08155	COG0656	L-ascorbic acid biosynthetic process
D8X09_08170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D8X09_08175	COG0583	DNA-binding transcription factor activity
D8X09_08190	COG0783	Belongs to the Dps family
D8X09_08210	COG0463	Glycosyl transferase, family 2
D8X09_08230	COG0438	transferase activity, transferring glycosyl groups
D8X09_08245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D8X09_08270	COG0300	oxidoreductase activity
D8X09_08315	COG0861	Integral membrane protein TerC family
D8X09_08320	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_08340	COG0714	Associated with various cellular activities
D8X09_08375	COG3119	arylsulfatase activity
D8X09_08400	COG2197	response regulator
D8X09_08410	COG2944	sequence-specific DNA binding
D8X09_08420	COG0625	glutathione transferase activity
D8X09_08450	COG0179	Fumarylacetoacetate (FAA) hydrolase
D8X09_08455	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_08500	COG0431	NADPH-dependent FMN reductase
D8X09_08530	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_08535	COG0583	DNA-binding transcription factor activity
D8X09_08555	COG2111	Na H antiporter
D8X09_08555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8X09_08560	COG1006	Multisubunit Na H antiporter MnhC subunit
D8X09_08565	COG0651	ATP synthesis coupled electron transport
D8X09_08570	COG1863	multisubunit Na H antiporter MnhE subunit
D8X09_08575	COG2212	antiporter activity
D8X09_08600	COG0590	tRNA wobble adenosine to inosine editing
D8X09_08605	COG1619	proteins homologs of microcin C7 resistance protein MccF
D8X09_08610	COG1024	Enoyl-CoA hydratase
D8X09_08625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8X09_08630	COG0488	(ABC) transporter
D8X09_08665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8X09_08665	COG1017	nitric oxide dioxygenase activity
D8X09_08670	COG1959	2 iron, 2 sulfur cluster binding
D8X09_08675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_08695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D8X09_08700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D8X09_08705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8X09_08710	COG0084	hydrolase, TatD family'
D8X09_08725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_08735	COG1126	abc transporter atp-binding protein
D8X09_08745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8X09_08760	COG0028	Belongs to the TPP enzyme family
D8X09_08780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8X09_08830	COG4336	lyase activity
D8X09_08840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_08840	COG2205	protein histidine kinase activity
D8X09_08845	COG2197	response regulator
D8X09_08850	COG3064	Membrane
D8X09_08850	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8X09_08850	COG3210	domain, Protein
D8X09_08860	COG3121	Chaperone
D8X09_08865	COG3188	usher protein
D8X09_08870	COG3539	Fimbrial protein
D8X09_08875	COG2831	hemolysin activation secretion protein
D8X09_08890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8X09_08940	COG0668	transmembrane transport
D8X09_08965	COG1253	flavin adenine dinucleotide binding
D8X09_08970	COG1968	undecaprenyl-diphosphatase activity
D8X09_08975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8X09_08990	COG0215	cysteine-tRNA ligase activity
D8X09_09000	COG0825	malonyl-CoA metabolic process
D8X09_09010	COG0037	tRNA processing
D8X09_09015	COG0527	aspartate kinase activity
D8X09_09040	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8X09_09045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D8X09_09060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8X09_09065	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D8X09_09070	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_09080	COG0583	DNA-binding transcription factor activity
D8X09_09095	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8X09_09105	COG3842	ATPase activity
D8X09_09115	COG1902	pentaerythritol trinitrate reductase activity
D8X09_09115	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8X09_09120	COG1414	Transcriptional regulator
D8X09_09125	COG1832	CoA-binding protein
D8X09_09135	COG0251	oxidation-reduction process
D8X09_09160	COG1902	pentaerythritol trinitrate reductase activity
D8X09_09170	COG1215	transferase activity, transferring glycosyl groups
D8X09_09175	COG1649	PFAM Uncharacterised BCR, COG1649
D8X09_09175	COG0726	polysaccharide deacetylase
D8X09_09195	COG1846	Transcriptional regulator
D8X09_09200	COG2197	response regulator
D8X09_09215	COG0166	Belongs to the GPI family
D8X09_09220	COG1045	serine acetyltransferase
D8X09_09230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D8X09_09235	COG0483	inositol monophosphate 1-phosphatase activity
D8X09_09240	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_09245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D8X09_09260	COG0210	DNA helicase
D8X09_09265	COG0598	Magnesium transport protein CorA
D8X09_09275	COG0747	negative chemotaxis
D8X09_09280	COG0601	transmembrane transport
D8X09_09285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_09290	COG4172	Belongs to the ABC transporter superfamily
D8X09_09295	COG1846	Transcriptional regulator
D8X09_09350	COG4964	Belongs to the GSP D family
D8X09_09390	COG2204	response regulator
D8X09_09405	COG1595	DNA-templated transcription, initiation
D8X09_09415	COG3474	cytochrome
D8X09_09420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D8X09_09435	COG3384	dioxygenase
D8X09_09440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D8X09_09470	COG2885	chlorophyll binding
D8X09_09505	COG0697	spore germination
D8X09_09510	COG0730	response to heat
D8X09_09530	COG0583	DNA-binding transcription factor activity
D8X09_09535	COG0427	acetyl-CoA hydrolase
D8X09_09590	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8X09_09595	COG0154	amidase activity
D8X09_09605	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D8X09_09620	COG0495	leucyl-tRNA aminoacylation
D8X09_09625	COG2814	Major facilitator Superfamily
D8X09_09630	COG1846	Transcriptional regulator
D8X09_09655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D8X09_09660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D8X09_09665	COG2814	Major facilitator Superfamily
D8X09_09685	COG4176	ABC-type proline glycine betaine transport system permease component
D8X09_09695	COG1942	4-Oxalocrotonate Tautomerase
D8X09_09700	COG0183	Belongs to the thiolase family
D8X09_09710	COG1802	Transcriptional regulator
D8X09_09720	COG1024	Enoyl-CoA hydratase
D8X09_09735	COG2032	superoxide dismutase activity
D8X09_09750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D8X09_09775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8X09_09780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8X09_09790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D8X09_09795	COG0736	holo-[acyl-carrier-protein] synthase activity
D8X09_09800	COG1472	Belongs to the glycosyl hydrolase 3 family
D8X09_09805	COG0322	excinuclease ABC activity
D8X09_09810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D8X09_09820	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D8X09_09820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D8X09_09825	COG2224	Isocitrate lyase
D8X09_09845	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_09855	COG4638	Rieske (2fe-2S)
D8X09_09860	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D8X09_09865	COG1024	Enoyl-CoA hydratase
D8X09_09875	COG0633	Ferredoxin
D8X09_09880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_09895	COG0183	Belongs to the thiolase family
D8X09_09910	COG0583	DNA-binding transcription factor activity
D8X09_09940	COG2346	COG2346, Truncated hemoglobins
D8X09_10070	COG2207	Transcriptional regulator
D8X09_10120	COG1132	(ABC) transporter
D8X09_10145	COG0659	secondary active sulfate transmembrane transporter activity
D8X09_10175	COG2169	Transcriptional regulator
D8X09_10180	COG5507	3-demethylubiquinone-9 3-methyltransferase
D8X09_10185	COG0384	phenazine biosynthesis protein PhzF
D8X09_10190	COG0583	DNA-binding transcription factor activity
D8X09_10195	COG2733	membrane
D8X09_10210	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_10215	COG3284	Transcriptional regulator
D8X09_10240	COG1380	Effector of murein hydrolase LrgA
D8X09_10245	COG4106	trans-aconitate 2-methyltransferase activity
D8X09_10245	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D8X09_10255	COG0156	8-amino-7-oxononanoate synthase activity
D8X09_10325	COG1131	(ABC) transporter
D8X09_10330	COG0842	Transport permease protein
D8X09_10335	COG0628	permease
D8X09_10370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D8X09_10380	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D8X09_10390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D8X09_10395	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D8X09_10400	COG0330	HflC and HflK could
D8X09_10405	COG0330	HflC and HflK could
D8X09_10410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D8X09_10415	COG1923	regulation of RNA biosynthetic process
D8X09_10420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D8X09_10425	COG1160	GTP binding
D8X09_10430	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D8X09_10435	COG2976	Protein conserved in bacteria
D8X09_10440	COG0124	histidyl-tRNA synthetase
D8X09_10445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D8X09_10455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D8X09_10460	COG0105	UTP biosynthetic process
D8X09_10465	COG0525	valine-tRNA ligase activity
D8X09_10480	COG0642	Histidine kinase
D8X09_10505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D8X09_10510	COG0336	Belongs to the RNA methyltransferase TrmD family
D8X09_10515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D8X09_10520	COG0228	four-way junction DNA binding
D8X09_10530	COG0425	Belongs to the sulfur carrier protein TusA family
D8X09_10535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D8X09_10580	COG0154	amidase activity
D8X09_10585	COG4172	Belongs to the ABC transporter superfamily
D8X09_10590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_10595	COG0601	transmembrane transport
D8X09_10600	COG0747	negative chemotaxis
D8X09_10630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_10640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D8X09_10660	COG3395	kinase activity
D8X09_10675	COG1024	Enoyl-CoA hydratase
D8X09_10695	COG0633	Ferredoxin
D8X09_10700	COG0443	Heat shock 70 kDa protein
D8X09_10705	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D8X09_10710	COG0316	Belongs to the HesB IscA family
D8X09_10715	COG0822	iron-sulfur transferase activity
D8X09_10720	COG1104	cysteine desulfurase activity
D8X09_10730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8X09_10735	COG0556	nucleotide-excision repair
D8X09_10745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D8X09_10775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8X09_10795	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_10800	COG0183	Belongs to the thiolase family
D8X09_10810	COG1024	Enoyl-CoA hydratase
D8X09_10825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_10830	COG0583	DNA-binding transcription factor activity
D8X09_10835	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D8X09_10840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D8X09_10845	COG0740	serine-type endopeptidase activity
D8X09_10850	COG0544	peptidyl-prolyl cis-trans isomerase activity
D8X09_10860	COG1278	Cold shock
D8X09_10870	COG1278	Cold shock
D8X09_10905	COG2171	N-acyltransferase activity
D8X09_10910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8X09_10915	COG2890	protein-(glutamine-N5) methyltransferase activity
D8X09_10920	COG0488	(ABC) transporter
D8X09_10925	COG4771	TonB-dependent receptor
D8X09_10930	COG0210	DNA helicase
D8X09_10950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D8X09_10955	COG0196	riboflavin kinase activity
D8X09_10960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D8X09_10965	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D8X09_10970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D8X09_10980	COG1522	sequence-specific DNA binding
D8X09_11000	COG2951	lytic endotransglycosylase activity
D8X09_11005	COG2833	Protein of unknown function (DUF455)
D8X09_11035	COG3237	CsbD-like
D8X09_11045	COG2823	Periplasmic or secreted lipoprotein
D8X09_11070	COG4181	ATPase activity
D8X09_11080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8X09_11085	COG0584	glycerophosphoryl diester phosphodiesterase
D8X09_11090	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D8X09_11100	COG0678	peroxiredoxin activity
D8X09_11100	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D8X09_11110	COG0789	Transcriptional regulator
D8X09_11115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D8X09_11140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D8X09_11145	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D8X09_11150	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D8X09_11160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D8X09_11165	COG2252	PERMEase
D8X09_11175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8X09_11205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8X09_11245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8X09_11250	COG1366	Belongs to the anti-sigma-factor antagonist family
D8X09_11255	COG2172	sigma factor antagonist activity
D8X09_11260	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D8X09_11270	COG2208	phosphoserine phosphatase activity
D8X09_11270	COG2770	Histidine kinase
D8X09_11295	COG1595	DNA-templated transcription, initiation
D8X09_11310	COG4792	protein secretion
D8X09_11315	COG4791	protein targeting
D8X09_11320	COG4794	Type iii secretion
D8X09_11325	COG4790	Type iii secretion
D8X09_11330	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D8X09_11360	COG4669	(LipO)protein
D8X09_11425	COG4789	Type iii secretion
D8X09_11455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D8X09_11460	COG0840	transmembrane signaling receptor activity
D8X09_11465	COG2233	PERMEase
D8X09_11490	COG1840	ABC-type Fe3 transport system, periplasmic component
D8X09_11495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D8X09_11500	COG1178	ABC-type Fe3 transport system permease component
D8X09_11505	COG3842	ATPase activity
D8X09_11510	COG0583	DNA-binding transcription factor activity
D8X09_11530	COG0501	Belongs to the peptidase M48B family
D8X09_11540	COG0697	spore germination
D8X09_11550	COG1846	Transcriptional regulator
D8X09_11560	COG1566	PFAM secretion protein HlyD family protein
D8X09_11565	COG2814	Major facilitator Superfamily
D8X09_11570	COG0473	3-isopropylmalate dehydrogenase activity
D8X09_11580	COG0747	negative chemotaxis
D8X09_11590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_11605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D8X09_11630	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_11640	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8X09_11645	COG1115	amino acid carrier protein
D8X09_11650	COG0433	COG0433 Predicted ATPase
D8X09_11655	COG0217	transcriptional regulatory protein
D8X09_11660	COG0151	Belongs to the GarS family
D8X09_11665	COG0408	coproporphyrinogen oxidase activity
D8X09_11670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D8X09_11675	COG0799	negative regulation of ribosome biogenesis
D8X09_11680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D8X09_11685	COG0424	maF-like protein
D8X09_11690	COG3468	outer membrane autotransporter barrel domain protein
D8X09_11730	COG1530	ribonuclease E activity
D8X09_11735	COG0077	Prephenate dehydratase
D8X09_11750	COG1132	(ABC) transporter
D8X09_11755	COG0859	PFAM glycosyl transferase family 9
D8X09_11780	COG2194	sulfuric ester hydrolase activity
D8X09_11785	COG0438	transferase activity, transferring glycosyl groups
D8X09_11790	COG0463	Glycosyl transferase, family 2
D8X09_11795	COG0726	polysaccharide deacetylase
D8X09_11800	COG0438	transferase activity, transferring glycosyl groups
D8X09_11815	COG1643	Atp-dependent helicase
D8X09_11820	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D8X09_11820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D8X09_11825	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D8X09_11835	COG0704	Plays a role in the regulation of phosphate uptake
D8X09_11840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D8X09_11845	COG1960	acyl-CoA dehydrogenase activity
D8X09_11860	COG2094	Belongs to the DNA glycosylase MPG family
D8X09_11870	COG1177	transmembrane transport
D8X09_11875	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8X09_11880	COG3842	ATPase activity
D8X09_11885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D8X09_11890	COG3642	lipopolysaccharide core region biosynthetic process
D8X09_11900	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D8X09_11905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8X09_11930	COG0372	Belongs to the citrate synthase family
D8X09_11935	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D8X09_11940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D8X09_11945	COG1053	succinate dehydrogenase
D8X09_11950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D8X09_11955	COG2009	succinate dehydrogenase
D8X09_11960	COG2188	Transcriptional regulator
D8X09_11965	COG0039	L-malate dehydrogenase activity
D8X09_12020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8X09_12030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D8X09_12060	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D8X09_12065	COG0148	phosphopyruvate hydratase activity
D8X09_12080	COG0504	CTP synthase activity
D8X09_12105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_12115	COG0747	negative chemotaxis
D8X09_12120	COG4172	Belongs to the ABC transporter superfamily
D8X09_12125	COG1446	asparaginase
D8X09_12155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8X09_12170	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D8X09_12175	COG0697	spore germination
D8X09_12180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8X09_12190	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D8X09_12200	COG0791	NLP P60 protein
D8X09_12215	COG0583	DNA-binding transcription factor activity
D8X09_12230	COG0583	DNA-binding transcription factor activity
D8X09_12240	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D8X09_12255	COG0670	Belongs to the BI1 family
D8X09_12260	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_12275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D8X09_12285	COG1381	Involved in DNA repair and RecF pathway recombination
D8X09_12290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D8X09_12295	COG0571	ribonuclease III activity
D8X09_12300	COG0681	Belongs to the peptidase S26 family
D8X09_12305	COG0481	GTPase activity
D8X09_12310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8X09_12335	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D8X09_12340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8X09_12355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8X09_12360	COG0416	fatty acid biosynthetic process
D8X09_12365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D8X09_12370	COG1399	metal-binding, possibly nucleic acid-binding protein
D8X09_12375	COG0424	maF-like protein
D8X09_12385	COG3023	N-Acetylmuramoyl-L-alanine amidase
D8X09_12400	COG3022	response to hydroperoxide
D8X09_12410	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_12455	COG2814	Major facilitator Superfamily
D8X09_12475	COG3706	GGDEF domain
D8X09_12500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D8X09_12505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D8X09_12510	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D8X09_12515	COG1674	ftsk spoiiie
D8X09_12520	COG0492	ferredoxin-NADP+ reductase activity
D8X09_12525	COG1193	negative regulation of DNA recombination
D8X09_12540	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8X09_12555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D8X09_12560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D8X09_12565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D8X09_12575	COG0745	RESPONSE REGULATOR receiver
D8X09_12620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8X09_12640	COG0612	Peptidase, M16
D8X09_12650	COG0443	Heat shock 70 kDa protein
D8X09_12660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D8X09_12670	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D8X09_12675	COG1420	regulation of RNA biosynthetic process
D8X09_12680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D8X09_12685	COG0497	DNA recombination
D8X09_12690	COG0735	belongs to the Fur family
D8X09_12695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D8X09_12700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D8X09_12705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D8X09_12740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D8X09_12740	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8X09_12745	COG4311	Sarcosine oxidase, delta subunit
D8X09_12750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_12760	COG0583	DNA-binding transcription factor activity
D8X09_12770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D8X09_12795	COG4964	Belongs to the GSP D family
D8X09_12835	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D8X09_12855	COG0181	hydroxymethylbilane synthase activity
D8X09_12860	COG0861	Integral membrane protein TerC family
D8X09_12865	COG0861	Integral membrane protein TerC family
D8X09_12870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D8X09_12875	COG0045	succinate-CoA ligase (ADP-forming) activity
D8X09_12885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D8X09_12890	COG0583	DNA-binding transcription factor activity
D8X09_12895	COG2137	regulation of response to DNA damage stimulus
D8X09_12900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D8X09_12910	COG0642	Histidine kinase
D8X09_12920	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8X09_12920	COG1024	Enoyl-CoA hydratase
D8X09_12925	COG3842	ATPase activity
D8X09_12940	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_12960	COG0583	DNA-binding transcription factor activity
D8X09_12965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_12975	COG2974	May be involved in recombination
D8X09_12980	COG0540	Belongs to the ATCase OTCase family
D8X09_13045	COG0776	regulation of translation
D8X09_13050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8X09_13050	COG0072	phenylalanine-tRNA ligase activity
D8X09_13055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D8X09_13060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D8X09_13065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D8X09_13080	COG0756	dUTP diphosphatase activity
D8X09_13090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8X09_13105	COG0500	methyltransferase
D8X09_13120	COG0586	Pfam SNARE associated Golgi protein
D8X09_13150	COG1609	Transcriptional regulator
D8X09_13155	COG4172	Belongs to the ABC transporter superfamily
D8X09_13165	COG0601	transmembrane transport
D8X09_13170	COG0747	negative chemotaxis
D8X09_13190	COG1280	lysine exporter protein (LysE YggA)
D8X09_13205	COG2814	Major facilitator Superfamily
D8X09_13235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D8X09_13255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D8X09_13290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_13295	COG1116	anion transmembrane transporter activity
D8X09_13305	COG1228	amidohydrolase
D8X09_13320	COG0477	Major facilitator Superfamily
D8X09_13330	COG3550	peptidyl-serine autophosphorylation
D8X09_13345	COG0519	Catalyzes the synthesis of GMP from XMP
D8X09_13345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8X09_13390	COG0420	3'-5' exonuclease activity
D8X09_13395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_13425	COG0395	ABC-type sugar transport system, permease component
D8X09_13435	COG3842	ATPase activity
D8X09_13460	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_13465	COG1053	succinate dehydrogenase
D8X09_13495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8X09_13520	COG0602	queuosine metabolic process
D8X09_13525	COG0720	synthase
D8X09_13530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8X09_13535	COG0235	Class ii aldolase
D8X09_13565	COG3064	Membrane
D8X09_13565	COG3210	domain, Protein
D8X09_13565	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8X09_13570	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D8X09_13570	COG0047	phosphoribosylformylglycinamidine synthase activity
D8X09_13575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D8X09_13580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D8X09_13585	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8X09_13605	COG3539	Fimbrial protein
D8X09_13615	COG2050	protein possibly involved in aromatic compounds catabolism
D8X09_13620	COG1024	Enoyl-CoA hydratase
D8X09_13625	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_13645	COG2151	metal-sulfur cluster biosynthetic enzyme
D8X09_13650	COG3396	Phenylacetate-CoA oxygenase
D8X09_13655	COG3460	Phenylacetate-CoA oxygenase
D8X09_13660	COG3396	Phenylacetate-CoA oxygenase
D8X09_13665	COG3327	negative regulation of DNA-templated transcription, initiation
D8X09_13675	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D8X09_13680	COG0501	Belongs to the peptidase M48B family
D8X09_13685	COG1162	GTPase activity
D8X09_13700	COG0601	transmembrane transport
D8X09_13705	COG0747	negative chemotaxis
D8X09_13750	COG0668	transmembrane transport
D8X09_13755	COG0165	Argininosuccinate lyase
D8X09_13775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D8X09_13780	COG0303	'Molybdopterin
D8X09_13785	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8X09_13800	COG0315	cyclic pyranopterin monophosphate synthase activity
D8X09_13810	COG0412	Dienelactone hydrolase
D8X09_13820	COG0678	peroxiredoxin activity
D8X09_13830	COG0697	spore germination
D8X09_13835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D8X09_13860	COG0789	Transcriptional regulator
D8X09_13880	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_13890	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D8X09_13895	COG1845	cytochrome c oxidase, subunit III
D8X09_13900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8X09_13910	COG0477	Major facilitator Superfamily
D8X09_13945	COG1309	transcriptional regulator
D8X09_13950	COG2271	Major facilitator Superfamily
D8X09_13970	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_13985	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D8X09_13985	COG0506	proline dehydrogenase activity
D8X09_13985	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D8X09_13995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D8X09_13995	COG3008	intermembrane lipid transfer
D8X09_14000	COG2995	paraquat-inducible protein a
D8X09_14005	COG0542	response to heat
D8X09_14010	COG4953	penicillin-binding protein 1C
D8X09_14020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D8X09_14025	COG1278	Cold shock
D8X09_14035	COG0183	Belongs to the thiolase family
D8X09_14040	COG0038	chloride channel
D8X09_14045	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D8X09_14050	COG1570	exodeoxyribonuclease VII activity
D8X09_14060	COG0811	peptide transport
D8X09_14065	COG0848	biopolymer transport protein
D8X09_14070	COG1663	tetraacyldisaccharide 4'-kinase activity
D8X09_14075	COG2835	tetraacyldisaccharide 4'-kinase activity
D8X09_14080	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D8X09_14085	COG0563	adenylate kinase activity
D8X09_14095	COG0728	peptidoglycan biosynthetic process
D8X09_14105	COG0268	Binds directly to 16S ribosomal RNA
D8X09_14140	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D8X09_14165	COG0436	Aminotransferase
D8X09_14170	COG3737	Protein of unknown function (DUF498/DUF598)
D8X09_14175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D8X09_14180	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D8X09_14185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D8X09_14195	COG0305	Participates in initiation and elongation during chromosome replication
D8X09_14205	COG0359	binds to the 23S rRNA
D8X09_14210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D8X09_14215	COG2965	DNA replication, synthesis of RNA primer
D8X09_14220	COG0360	Binds together with S18 to 16S ribosomal RNA
D8X09_14225	COG1469	GTP cyclohydrolase I activity
D8X09_14230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D8X09_14235	COG0142	geranyltranstransferase activity
D8X09_14240	COG1722	exodeoxyribonuclease VII activity
D8X09_14250	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_14270	COG2239	Acts as a magnesium transporter
D8X09_14275	COG1607	acyl-coa hydrolase
D8X09_14280	COG2855	membrane
D8X09_14290	COG1473	amidohydrolase
D8X09_14295	COG0318	PFAM AMP-dependent synthetase and ligase
D8X09_14320	COG1501	Belongs to the glycosyl hydrolase 31 family
D8X09_14325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D8X09_14330	COG2011	ABC-type metal ion transport system permease component
D8X09_14350	COG1454	alcohol dehydrogenase
D8X09_14380	COG2186	Transcriptional regulator
D8X09_14385	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_14405	COG1175	transmembrane transport
D8X09_14410	COG0395	ABC-type sugar transport system, permease component
D8X09_14415	COG3842	ATPase activity
D8X09_14430	COG1653	transport
D8X09_14450	COG2818	Glycosylase
D8X09_14455	COG2982	Protein involved in outer membrane biogenesis
D8X09_14465	COG1309	transcriptional regulator
D8X09_14470	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_14530	COG0583	DNA-binding transcription factor activity
D8X09_14535	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D8X09_14540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D8X09_14555	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_14560	COG0477	Major facilitator Superfamily
D8X09_14570	COG0583	DNA-binding transcription factor activity
D8X09_14575	COG1448	Aminotransferase
D8X09_14580	COG1418	mRNA catabolic process
D8X09_14605	COG1063	alcohol dehydrogenase
D8X09_14625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_14635	COG0318	PFAM AMP-dependent synthetase and ligase
D8X09_14645	COG1522	sequence-specific DNA binding
D8X09_14650	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_14655	COG0307	riboflavin synthase, alpha
D8X09_14660	COG0154	amidase activity
D8X09_14680	COG2807	transmembrane transport
D8X09_14685	COG0590	tRNA wobble adenosine to inosine editing
D8X09_14695	COG0583	DNA-binding transcription factor activity
D8X09_14715	COG0410	ABC transporter
D8X09_14730	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_14735	COG0251	oxidation-reduction process
D8X09_14740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8X09_14750	COG1414	Transcriptional regulator
D8X09_14755	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_14770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_14785	COG1024	Enoyl-CoA hydratase
D8X09_14790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_14795	COG0154	amidase activity
D8X09_14835	COG3909	cytochrome
D8X09_14840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D8X09_14845	COG0625	glutathione transferase activity
D8X09_14850	COG0730	response to heat
D8X09_14855	COG0482	sulfurtransferase activity
D8X09_14860	COG0583	DNA-binding transcription factor activity
D8X09_14875	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D8X09_14885	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D8X09_14900	COG2819	hydrolase of the alpha beta superfamily
D8X09_14905	COG0247	lactate metabolic process
D8X09_14910	COG0277	FAD linked oxidase domain protein
D8X09_14915	COG0277	FAD linked oxidase domain protein
D8X09_14920	COG0277	FAD linked oxidase domain protein
D8X09_14925	COG3210	domain, Protein
D8X09_14925	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8X09_14925	COG3064	Membrane
D8X09_14925	COG3210	domain, Protein
D8X09_14925	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8X09_14925	COG3064	Membrane
D8X09_14930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D8X09_14935	COG0312	modulator of DNA gyrase
D8X09_14940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D8X09_15015	COG3220	belongs to the UPF0276 family
D8X09_15035	COG0640	Transcriptional regulator
D8X09_15040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D8X09_15045	COG1845	cytochrome c oxidase, subunit III
D8X09_15050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8X09_15060	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D8X09_15100	COG0583	DNA-binding transcription factor activity
D8X09_15135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8X09_15135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8X09_15150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D8X09_15155	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D8X09_15165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D8X09_15180	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D8X09_15185	COG0316	Belongs to the HesB IscA family
D8X09_15195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D8X09_15200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D8X09_15205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D8X09_15210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8X09_15215	COG0312	modulator of DNA gyrase
D8X09_15220	COG3028	Belongs to the UPF0307 family
D8X09_15235	COG1116	anion transmembrane transporter activity
D8X09_15240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_15245	COG1335	isochorismatase
D8X09_15250	COG0346	lactoylglutathione lyase activity
D8X09_15255	COG0513	Belongs to the DEAD box helicase family
D8X09_15260	COG3069	C4-dicarboxylate transmembrane transporter activity
D8X09_15265	COG1802	Transcriptional regulator
D8X09_15280	COG1042	CoA-binding domain protein
D8X09_15280	COG0045	succinate-CoA ligase (ADP-forming) activity
D8X09_15280	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D8X09_15285	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8X09_15300	COG1522	sequence-specific DNA binding
D8X09_15335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8X09_15340	COG1696	Membrane protein involved in D-alanine export
D8X09_15380	COG0439	Biotin carboxylase
D8X09_15385	COG0511	ligase activity, forming carbon-carbon bonds
D8X09_15390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D8X09_15395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8X09_15400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8X09_15405	COG3150	esterase
D8X09_15410	COG0557	exoribonuclease II activity
D8X09_15420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D8X09_15440	COG1522	sequence-specific DNA binding
D8X09_15445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_15450	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_15470	COG0653	protein targeting
D8X09_15475	COG0739	heme binding
D8X09_15485	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D8X09_15490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D8X09_15500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D8X09_15505	COG1181	Belongs to the D-alanine--D-alanine ligase family
D8X09_15510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8X09_15515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D8X09_15525	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D8X09_15530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8X09_15535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D8X09_15545	COG3116	cell division
D8X09_15550	COG0275	rRNA processing
D8X09_15555	COG2001	Belongs to the MraZ family
D8X09_15570	COG0418	dihydroorotase activity
D8X09_15575	COG1473	amidohydrolase
D8X09_15615	COG1522	sequence-specific DNA binding
D8X09_15625	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D8X09_15630	COG4654	Cytochrome c, class I
D8X09_15635	COG0129	dihydroxy-acid dehydratase activity
D8X09_15640	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D8X09_15695	COG2084	Dehydrogenase
D8X09_15710	COG2096	Adenosyltransferase
D8X09_15725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D8X09_15730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D8X09_15735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D8X09_15740	COG0523	cobalamin synthesis protein
D8X09_15745	COG0735	belongs to the Fur family
D8X09_15755	COG1121	(ABC) transporter
D8X09_15765	COG0803	Belongs to the bacterial solute-binding protein 9 family
D8X09_15775	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D8X09_15785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D8X09_15795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D8X09_15800	COG1560	Kdo2-lipid A biosynthetic process
D8X09_15810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D8X09_15825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D8X09_15830	COG1950	PFAM Membrane protein of
D8X09_15845	COG0583	DNA-binding transcription factor activity
D8X09_15855	COG0477	Major facilitator Superfamily
D8X09_15870	COG0617	tRNA 3'-terminal CCA addition
D8X09_15880	COG0513	Belongs to the DEAD box helicase family
D8X09_15885	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D8X09_15895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8X09_15900	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D8X09_15975	COG0405	Gamma-glutamyltransferase
D8X09_15985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_16015	COG1309	transcriptional regulator
D8X09_16030	COG0745	RESPONSE REGULATOR receiver
D8X09_16080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D8X09_16105	COG0582	viral genome integration into host DNA
D8X09_16110	COG0012	GTP binding
D8X09_16120	COG0193	aminoacyl-tRNA hydrolase activity
D8X09_16125	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D8X09_16130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D8X09_16140	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D8X09_16145	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D8X09_16155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D8X09_16180	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D8X09_16190	COG1368	sulfuric ester hydrolase activity
D8X09_16195	COG0642	Histidine kinase
D8X09_16200	COG0745	RESPONSE REGULATOR receiver
D8X09_16205	COG0277	FAD linked oxidase domain protein
D8X09_16220	COG0166	Belongs to the GPI family
D8X09_16225	COG0438	transferase activity, transferring glycosyl groups
D8X09_16230	COG0438	transferase activity, transferring glycosyl groups
D8X09_16245	COG0438	transferase activity, transferring glycosyl groups
D8X09_16260	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D8X09_16265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8X09_16270	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D8X09_16280	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D8X09_16290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8X09_16305	COG0747	negative chemotaxis
D8X09_16310	COG0601	transmembrane transport
D8X09_16315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_16335	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D8X09_16340	COG0830	nickel cation binding
D8X09_16350	COG0804	urea catabolic process
D8X09_16355	COG0832	Belongs to the urease beta subunit family
D8X09_16365	COG0831	urea catabolic process
D8X09_16370	COG0829	nickel cation binding
D8X09_16395	COG2188	Transcriptional regulator
D8X09_16420	COG2719	SpoVR family
D8X09_16425	COG2718	Belongs to the UPF0229 family
D8X09_16445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_16460	COG1960	acyl-CoA dehydrogenase activity
D8X09_16480	COG0411	ABC transporter
D8X09_16560	COG0328	RNA-DNA hybrid ribonuclease activity
D8X09_16565	COG2226	methyltransferase
D8X09_16575	COG1388	LysM domain
D8X09_16575	COG0741	lytic transglycosylase activity
D8X09_16595	COG2979	Protein of unknown function (DUF533)
D8X09_16615	COG0745	RESPONSE REGULATOR receiver
D8X09_16630	COG1271	oxidase subunit
D8X09_16635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8X09_16640	COG0850	regulation of cytokinetic process
D8X09_16645	COG2894	cell division
D8X09_16650	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D8X09_16685	COG0601	transmembrane transport
D8X09_16695	COG1215	transferase activity, transferring glycosyl groups
D8X09_16710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D8X09_16720	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8X09_16740	COG0318	PFAM AMP-dependent synthetase and ligase
D8X09_16745	COG2188	Transcriptional regulator
D8X09_16750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D8X09_16755	COG2814	Major facilitator Superfamily
D8X09_16765	COG0259	pyridoxamine-phosphate oxidase activity
D8X09_16770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8X09_16785	COG0583	DNA-binding transcription factor activity
D8X09_16810	COG0134	indole-3-glycerol-phosphate synthase activity
D8X09_16815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D8X09_16820	COG0512	Glutamine amidotransferase of anthranilate synthase
D8X09_16830	COG0546	phosphoglycolate phosphatase activity
D8X09_16840	COG2967	ApaG domain
D8X09_16845	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D8X09_16850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8X09_16855	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8X09_16860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8X09_16870	COG0037	tRNA processing
D8X09_16880	COG3634	alkyl hydroperoxide reductase activity
D8X09_16885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8X09_16890	COG1024	Enoyl-CoA hydratase
D8X09_16915	COG0356	it plays a direct role in the translocation of protons across the membrane
D8X09_16925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D8X09_16930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D8X09_16935	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D8X09_16940	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D8X09_16945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D8X09_16950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D8X09_16960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D8X09_16965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D8X09_16970	COG0210	DNA helicase
D8X09_16980	COG2195	Cleaves the N-terminal amino acid of tripeptides
D8X09_16990	COG4172	Belongs to the ABC transporter superfamily
D8X09_16995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_17000	COG0601	transmembrane transport
D8X09_17020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D8X09_17025	COG1024	Enoyl-CoA hydratase
D8X09_17030	COG1024	Enoyl-CoA hydratase
D8X09_17085	COG2132	Multicopper oxidase
D8X09_17095	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8X09_17095	COG1024	Enoyl-CoA hydratase
D8X09_17105	COG1414	Transcriptional regulator
D8X09_17115	COG0154	amidase activity
D8X09_17145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8X09_17150	COG3568	Endonuclease Exonuclease Phosphatase
D8X09_17155	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D8X09_17190	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D8X09_17200	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D8X09_17215	COG1137	ATPase activity
D8X09_17230	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D8X09_17235	COG2010	Cytochrome c
D8X09_17235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D8X09_17250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D8X09_17285	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_17295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D8X09_17300	COG2890	protein-(glutamine-N5) methyltransferase activity
D8X09_17305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D8X09_17310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D8X09_17360	COG1960	acyl-CoA dehydrogenase activity
D8X09_17370	COG0183	Belongs to the thiolase family
D8X09_17375	COG1522	sequence-specific DNA binding
D8X09_17380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D8X09_17400	COG1024	Enoyl-CoA hydratase
D8X09_17415	COG0604	alcohol dehydrogenase
D8X09_17435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8X09_17445	COG1960	acyl-CoA dehydrogenase activity
D8X09_17450	COG1960	acyl-CoA dehydrogenase activity
D8X09_17455	COG0277	FAD linked oxidase domain protein
D8X09_17465	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_17490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8X09_17500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_17505	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_17510	COG1960	acyl-CoA dehydrogenase activity
D8X09_17530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8X09_17535	COG1024	Enoyl-CoA hydratase
D8X09_17540	COG1960	acyl-CoA dehydrogenase activity
D8X09_17560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D8X09_17565	COG0022	dehydrogenase e1 component
D8X09_17570	COG1024	Enoyl-CoA hydratase
D8X09_17575	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8X09_17595	COG0683	leucine binding
D8X09_17600	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_17605	COG0411	ABC transporter
D8X09_17610	COG0410	ABC transporter
D8X09_17615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8X09_17630	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_17655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D8X09_17660	COG0793	Belongs to the peptidase S41A family
D8X09_17665	COG4942	peptidase
D8X09_17670	COG0588	phosphoglycerate mutase activity
D8X09_17680	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D8X09_17685	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D8X09_17690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D8X09_17695	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_17710	COG2226	methyltransferase
D8X09_17715	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D8X09_17730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_17735	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8X09_17760	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8X09_17785	COG1335	isochorismatase
D8X09_17790	COG2309	aminopeptidase activity
D8X09_17800	COG3473	Maleate cis-trans isomerase
D8X09_17810	COG2068	MobA-Related Protein
D8X09_17830	COG0569	domain protein
D8X09_17835	COG2204	response regulator
D8X09_17840	COG5000	phosphorelay sensor kinase activity
D8X09_17850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D8X09_17850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8X09_17860	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D8X09_17895	COG0583	DNA-binding transcription factor activity
D8X09_17915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8X09_17920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_17935	COG0758	DNA mediated transformation
D8X09_17940	COG1522	sequence-specific DNA binding
D8X09_17950	COG0242	peptide deformylase activity
D8X09_17965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D8X09_17975	COG0546	phosphoglycolate phosphatase activity
D8X09_18000	COG1942	4-Oxalocrotonate Tautomerase
D8X09_18005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8X09_18030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8X09_18050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8X09_18055	COG1024	Enoyl-CoA hydratase
D8X09_18060	COG1414	Transcriptional regulator
D8X09_18065	COG0318	PFAM AMP-dependent synthetase and ligase
D8X09_18070	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_18120	COG0330	HflC and HflK could
D8X09_18130	COG0251	oxidation-reduction process
D8X09_18180	COG3723	Recombinational DNA repair protein, rece pathway
D8X09_18215	COG0582	viral genome integration into host DNA
D8X09_18250	COG0706	membrane insertase activity
D8X09_18255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D8X09_18260	COG0594	ribonuclease P activity
D8X09_18265	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D8X09_18285	COG1414	Transcriptional regulator
D8X09_18290	COG0154	amidase activity
D8X09_18305	COG1304	FMN binding
D8X09_18355	COG0183	Belongs to the thiolase family
D8X09_18360	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D8X09_18375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8X09_18380	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_18400	COG1629	transport
D8X09_18405	COG2922	Belongs to the Smg family
D8X09_18430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8X09_18435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_18440	COG1028	Short-chain dehydrogenase reductase Sdr
D8X09_18445	COG1012	belongs to the aldehyde dehydrogenase family
D8X09_18455	COG0028	Belongs to the TPP enzyme family
D8X09_18460	COG1522	sequence-specific DNA binding
D8X09_18465	COG3781	membrane
D8X09_18475	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D8X09_18495	COG4206	TonB-dependent receptor
D8X09_18500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D8X09_18505	COG2022	thiamine diphosphate biosynthetic process
D8X09_18510	COG0351	phosphomethylpyrimidine kinase
D8X09_18515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D8X09_18530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D8X09_18540	COG0628	permease
D8X09_18550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8X09_18565	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D8X09_18570	COG0049	tRNA binding
D8X09_18575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D8X09_18580	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D8X09_18585	COG0051	transcription antitermination factor activity, RNA binding
D8X09_18590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D8X09_18595	COG0088	Forms part of the polypeptide exit tunnel
D8X09_18600	COG0089	rRNA binding
D8X09_18605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D8X09_18610	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D8X09_18615	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D8X09_18620	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D8X09_18625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D8X09_18630	COG0255	Belongs to the universal ribosomal protein uL29 family
D8X09_18635	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D8X09_18655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D8X09_18660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D8X09_18665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D8X09_18670	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D8X09_18675	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D8X09_18680	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D8X09_18685	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D8X09_18690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D8X09_18695	COG1841	ribosomal large subunit assembly
D8X09_18700	COG0200	Binds to the 23S rRNA
D8X09_18705	COG0201	protein transport
D8X09_18710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D8X09_18715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D8X09_18720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D8X09_18725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D8X09_18730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D8X09_18735	COG0202	RNA polymerase activity
D8X09_18740	COG0203	ribosomal protein L17
D8X09_18745	COG0537	adenosine 5'-monophosphoramidase activity
D8X09_18750	COG1324	tolerance protein
D8X09_18755	COG4232	protein-disulfide reductase activity
D8X09_18770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D8X09_18780	COG1333	cytochrome c biogenesis protein
D8X09_18785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D8X09_18800	COG1965	Belongs to the frataxin family
D8X09_18815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D8X09_18820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D8X09_18835	COG2814	Major facilitator Superfamily
D8X09_18840	COG0629	single-stranded DNA binding
D8X09_18890	COG0438	transferase activity, transferring glycosyl groups
D8X09_18910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_18935	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D8X09_18960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8X09_18965	COG1956	GAF domain-containing protein
D8X09_18970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8X09_18985	COG1652	LysM domain
D8X09_19000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D8X09_19015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8X09_19045	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_19060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_19075	COG1024	Enoyl-CoA hydratase
D8X09_19090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_19095	COG1309	transcriptional regulator
D8X09_19100	COG2816	NAD+ diphosphatase activity
D8X09_19105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8X09_19145	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8X09_19190	COG2814	Major facilitator Superfamily
D8X09_19195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D8X09_19215	COG1999	signal sequence binding
D8X09_19220	COG0109	protoheme IX farnesyltransferase activity
D8X09_19260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8X09_19280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D8X09_19285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D8X09_19295	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D8X09_19300	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D8X09_19310	COG0069	glutamate synthase activity
D8X09_19310	COG0067	glutamate synthase
D8X09_19310	COG0070	glutamate synthase
D8X09_19320	COG3047	cAMP biosynthetic process
D8X09_19330	COG1127	ABC transporter
D8X09_19335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8X09_19340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D8X09_19345	COG2853	Lipoprotein
D8X09_19360	COG0842	Transport permease protein
D8X09_19370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D8X09_19375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D8X09_19380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D8X09_19385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D8X09_19390	COG0131	Imidazoleglycerol-phosphate dehydratase
D8X09_19395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D8X09_19400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D8X09_19405	COG0107	imidazoleglycerol-phosphate synthase activity
D8X09_19410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D8X09_19420	COG0537	adenosine 5'-monophosphoramidase activity
D8X09_19425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D8X09_19430	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D8X09_19445	COG3181	Tripartite tricarboxylate transporter family receptor
D8X09_19485	COG3451	type IV secretory pathway VirB4
D8X09_19505	COG3504	Conjugal transfer protein
D8X09_19510	COG2948	multi-organism process
D8X09_19525	COG0697	spore germination
D8X09_19545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D8X09_19550	COG0747	negative chemotaxis
D8X09_19560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8X09_19575	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D8X09_19585	COG0494	nUDIX hydrolase
D8X09_19610	COG1538	Outer membrane efflux protein
D8X09_19630	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D8X09_19635	COG0237	dephospho-CoA kinase activity
D8X09_19640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D8X09_19655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D8X09_19660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D8X09_19670	COG0477	Major facilitator Superfamily
D8X09_19675	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D8X09_19690	COG1126	abc transporter atp-binding protein
D8X09_19695	COG0765	amino acid transport
D8X09_19700	COG4597	amino acid ABC transporter
D8X09_19705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8X09_19710	COG2884	Cell division ATP-binding protein ftsE
D8X09_19715	COG2177	Part of the ABC transporter FtsEX involved in
D8X09_19720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D8X09_19730	COG1194	a g-specific adenine glycosylase
D8X09_19740	COG2226	methyltransferase
D8X09_19750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_19755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_19770	COG1024	Enoyl-CoA hydratase
D8X09_19790	COG1024	Enoyl-CoA hydratase
D8X09_19795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8X09_19810	COG0753	catalase activity
D8X09_19815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8X09_19820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8X09_19830	COG2175	clavaminate synthase activity
D8X09_19835	COG1473	amidohydrolase
D8X09_19840	COG4608	Belongs to the ABC transporter superfamily
D8X09_19845	COG0444	Belongs to the ABC transporter superfamily
D8X09_19855	COG0601	transmembrane transport
D8X09_19860	COG0747	negative chemotaxis
D8X09_19865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D8X09_19880	COG5002	protein histidine kinase activity
D8X09_19880	COG3850	Histidine kinase
D8X09_19900	COG0436	Aminotransferase