locus-tag	class	description
D8Z23_00005	COG0445	tRNA wobble uridine modification
D8Z23_00015	COG1192	Involved in chromosome partitioning
D8Z23_00025	COG1475	DNA binding
D8Z23_00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D8Z23_00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D8Z23_00070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D8Z23_00075	COG0081	regulation of translation
D8Z23_00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D8Z23_00085	COG0222	ribosome binding
D8Z23_00090	COG0085	RNA polymerase activity
D8Z23_00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D8Z23_00135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_00160	COG1024	Enoyl-CoA hydratase
D8Z23_00180	COG0752	glycyl-tRNA synthetase alpha subunit
D8Z23_00185	COG0751	glycine-tRNA ligase activity
D8Z23_00190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D8Z23_00195	COG0204	Acyl-transferase
D8Z23_00210	COG0242	peptide deformylase activity
D8Z23_00250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8Z23_00255	COG2813	Specifically methylates the guanine in position
D8Z23_00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8Z23_00270	COG2223	nitrite transmembrane transporter activity
D8Z23_00280	COG1794	racemase activity, acting on amino acids and derivatives
D8Z23_00285	COG1126	abc transporter atp-binding protein
D8Z23_00290	COG0765	amino acid transport
D8Z23_00295	COG0765	amino acid transport
D8Z23_00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_00365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8Z23_00395	COG0326	Molecular chaperone. Has ATPase activity
D8Z23_00400	COG0625	glutathione transferase activity
D8Z23_00415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D8Z23_00420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D8Z23_00450	COG0438	transferase activity, transferring glycosyl groups
D8Z23_00455	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D8Z23_00460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D8Z23_00490	COG0859	PFAM glycosyl transferase family 9
D8Z23_00505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D8Z23_00515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8Z23_00520	COG1127	ABC transporter
D8Z23_00540	COG1686	Belongs to the peptidase S11 family
D8Z23_00550	COG2921	Belongs to the UPF0250 family
D8Z23_00555	COG0321	lipoyl(octanoyl) transferase activity
D8Z23_00560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D8Z23_00595	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8Z23_00605	COG0018	arginyl-trna synthetase
D8Z23_00625	COG0395	ABC-type sugar transport system, permease component
D8Z23_00630	COG1175	transmembrane transport
D8Z23_00635	COG1653	transport
D8Z23_00640	COG3842	ATPase activity
D8Z23_00645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D8Z23_00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D8Z23_00675	COG1609	Transcriptional regulator
D8Z23_00685	COG0154	amidase activity
D8Z23_00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8Z23_00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D8Z23_00710	COG0583	DNA-binding transcription factor activity
D8Z23_00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8Z23_00745	COG1802	Transcriptional regulator
D8Z23_00760	COG1024	Enoyl-CoA hydratase
D8Z23_00770	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_00785	COG1984	allophanate hydrolase subunit 2
D8Z23_00790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D8Z23_00800	COG0583	DNA-binding transcription factor activity
D8Z23_00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8Z23_00815	COG5002	protein histidine kinase activity
D8Z23_00825	COG5002	protein histidine kinase activity
D8Z23_00830	COG0745	RESPONSE REGULATOR receiver
D8Z23_00835	COG2226	methyltransferase
D8Z23_00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D8Z23_00870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D8Z23_00880	COG0513	Belongs to the DEAD box helicase family
D8Z23_00885	COG1280	lysine exporter protein (LysE YggA)
D8Z23_00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D8Z23_00930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8Z23_00930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8Z23_00940	COG0489	protein tyrosine kinase activity
D8Z23_00955	COG0717	Belongs to the dCTP deaminase family
D8Z23_00980	COG1982	Orn Lys Arg decarboxylase major
D8Z23_00985	COG2081	HI0933 family
D8Z23_00995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D8Z23_01005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D8Z23_01010	COG0509	glycine decarboxylation via glycine cleavage system
D8Z23_01015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D8Z23_01015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D8Z23_01055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8Z23_01070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8Z23_01080	COG1414	Transcriptional regulator
D8Z23_01085	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_01090	COG2031	fatty acid transporter
D8Z23_01095	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8Z23_01105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D8Z23_01110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D8Z23_01120	COG4257	antibiotic catabolic process
D8Z23_01145	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_01150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D8Z23_01155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8Z23_01180	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_01190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8Z23_01200	COG2188	Transcriptional regulator
D8Z23_01205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8Z23_01230	COG0617	tRNA 3'-terminal CCA addition
D8Z23_01245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D8Z23_01250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D8Z23_01255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D8Z23_01260	COG0586	Pfam SNARE associated Golgi protein
D8Z23_01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
D8Z23_01270	COG0802	atpase or kinase
D8Z23_01275	COG0114	fumarate hydratase activity
D8Z23_01285	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_01295	COG0405	Gamma-glutamyltransferase
D8Z23_01300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_01330	COG1294	oxidase, subunit
D8Z23_01340	COG4988	ABC transporter
D8Z23_01345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D8Z23_01350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D8Z23_01395	COG2969	positive regulation of protein catabolic process
D8Z23_01400	COG0625	glutathione transferase activity
D8Z23_01405	COG2857	Cytochrome c1
D8Z23_01410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D8Z23_01415	COG0723	plastoquinol--plastocyanin reductase activity
D8Z23_01420	COG1970	mechanosensitive ion channel activity
D8Z23_01425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D8Z23_01440	COG2808	Putative FMN-binding domain
D8Z23_01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8Z23_01450	COG0747	negative chemotaxis
D8Z23_01455	COG0657	acetylesterase activity
D8Z23_01465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8Z23_01470	COG2207	Transcriptional regulator
D8Z23_01475	COG0129	dihydroxy-acid dehydratase activity
D8Z23_01480	COG2814	Major facilitator Superfamily
D8Z23_01485	COG0583	DNA-binding transcription factor activity
D8Z23_01495	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
D8Z23_01535	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_01545	COG0411	ABC transporter
D8Z23_01550	COG0410	ABC transporter
D8Z23_01565	COG1024	Enoyl-CoA hydratase
D8Z23_01570	COG1960	acyl-CoA dehydrogenase activity
D8Z23_01595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D8Z23_01615	COG1678	Uncharacterized ACR, COG1678
D8Z23_01620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D8Z23_01625	COG0540	Belongs to the ATCase OTCase family
D8Z23_01640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D8Z23_01650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8Z23_01685	COG1234	tRNA 3'-trailer cleavage
D8Z23_01705	COG3064	Membrane
D8Z23_01720	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8Z23_01735	COG1683	Conserved Protein
D8Z23_01740	COG1120	ATPase activity
D8Z23_01745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8Z23_01750	COG4558	Periplasmic binding protein
D8Z23_01755	COG3720	iron ion transport
D8Z23_01765	COG3712	iron ion homeostasis
D8Z23_01770	COG1595	DNA-templated transcription, initiation
D8Z23_01805	COG1802	Transcriptional regulator
D8Z23_01815	COG3069	C4-dicarboxylate transmembrane transporter activity
D8Z23_01825	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_01860	COG2860	membrane
D8Z23_01865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8Z23_01870	COG0708	Exodeoxyribonuclease III
D8Z23_01875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D8Z23_01880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8Z23_01885	COG0154	amidase activity
D8Z23_01890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8Z23_01895	COG1077	Cell shape determining protein MreB Mrl
D8Z23_01900	COG1792	Involved in formation and maintenance of cell shape
D8Z23_01910	COG0768	penicillin binding
D8Z23_01915	COG0772	Belongs to the SEDS family
D8Z23_01920	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D8Z23_01925	COG0471	metal ion transport
D8Z23_01930	COG1309	transcriptional regulator
D8Z23_01940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D8Z23_01955	COG2823	Periplasmic or secreted lipoprotein
D8Z23_01960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D8Z23_01975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8Z23_01995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_02005	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_02025	COG0492	ferredoxin-NADP+ reductase activity
D8Z23_02035	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_02040	COG1024	Enoyl-CoA hydratase
D8Z23_02040	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8Z23_02045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_02050	COG0028	Belongs to the TPP enzyme family
D8Z23_02075	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_02090	COG0697	spore germination
D8Z23_02120	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D8Z23_02125	COG0463	Glycosyl transferase, family 2
D8Z23_02140	COG0786	glutamate:sodium symporter activity
D8Z23_02150	COG2031	fatty acid transporter
D8Z23_02165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D8Z23_02195	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_02205	COG0277	FAD linked oxidase domain protein
D8Z23_02210	COG1960	acyl-CoA dehydrogenase activity
D8Z23_02215	COG1960	acyl-CoA dehydrogenase activity
D8Z23_02225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8Z23_02240	COG2072	flavoprotein involved in K transport
D8Z23_02245	COG0604	alcohol dehydrogenase
D8Z23_02260	COG1024	Enoyl-CoA hydratase
D8Z23_02280	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D8Z23_02285	COG1522	sequence-specific DNA binding
D8Z23_02290	COG0183	Belongs to the thiolase family
D8Z23_02300	COG1960	acyl-CoA dehydrogenase activity
D8Z23_02345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D8Z23_02350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D8Z23_02355	COG2890	protein-(glutamine-N5) methyltransferase activity
D8Z23_02360	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D8Z23_02370	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_02405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D8Z23_02420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D8Z23_02420	COG2010	Cytochrome c
D8Z23_02425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D8Z23_02440	COG1137	ATPase activity
D8Z23_02455	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D8Z23_02465	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D8Z23_02500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D8Z23_02505	COG3568	Endonuclease Exonuclease Phosphatase
D8Z23_02510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8Z23_02540	COG0154	amidase activity
D8Z23_02550	COG1414	Transcriptional regulator
D8Z23_02560	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8Z23_02560	COG1024	Enoyl-CoA hydratase
D8Z23_02570	COG2132	Multicopper oxidase
D8Z23_02625	COG1024	Enoyl-CoA hydratase
D8Z23_02630	COG1024	Enoyl-CoA hydratase
D8Z23_02635	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D8Z23_02655	COG0601	transmembrane transport
D8Z23_02660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_02665	COG4172	Belongs to the ABC transporter superfamily
D8Z23_02675	COG2195	Cleaves the N-terminal amino acid of tripeptides
D8Z23_02685	COG0210	DNA helicase
D8Z23_02690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D8Z23_02695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D8Z23_02705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D8Z23_02710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D8Z23_02715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D8Z23_02720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D8Z23_02725	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D8Z23_02730	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D8Z23_02740	COG0356	it plays a direct role in the translocation of protons across the membrane
D8Z23_02765	COG1024	Enoyl-CoA hydratase
D8Z23_02770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8Z23_02775	COG3634	alkyl hydroperoxide reductase activity
D8Z23_02785	COG0037	tRNA processing
D8Z23_02795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8Z23_02800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8Z23_02805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8Z23_02810	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D8Z23_02815	COG2967	ApaG domain
D8Z23_02825	COG0546	phosphoglycolate phosphatase activity
D8Z23_02835	COG0512	Glutamine amidotransferase of anthranilate synthase
D8Z23_02840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D8Z23_02845	COG0134	indole-3-glycerol-phosphate synthase activity
D8Z23_02875	COG0583	DNA-binding transcription factor activity
D8Z23_02890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8Z23_02895	COG0259	pyridoxamine-phosphate oxidase activity
D8Z23_02905	COG2814	Major facilitator Superfamily
D8Z23_02910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D8Z23_02915	COG2188	Transcriptional regulator
D8Z23_02920	COG0318	PFAM AMP-dependent synthetase and ligase
D8Z23_02940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8Z23_02950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D8Z23_02965	COG1215	transferase activity, transferring glycosyl groups
D8Z23_02975	COG0601	transmembrane transport
D8Z23_03010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D8Z23_03015	COG2894	cell division
D8Z23_03020	COG0850	regulation of cytokinetic process
D8Z23_03025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8Z23_03030	COG1271	oxidase subunit
D8Z23_03045	COG0745	RESPONSE REGULATOR receiver
D8Z23_03065	COG2979	Protein of unknown function (DUF533)
D8Z23_03085	COG1388	LysM domain
D8Z23_03085	COG0741	lytic transglycosylase activity
D8Z23_03095	COG2226	methyltransferase
D8Z23_03100	COG0328	RNA-DNA hybrid ribonuclease activity
D8Z23_03180	COG0411	ABC transporter
D8Z23_03200	COG1960	acyl-CoA dehydrogenase activity
D8Z23_03215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_03235	COG2718	Belongs to the UPF0229 family
D8Z23_03240	COG2719	SpoVR family
D8Z23_03265	COG2188	Transcriptional regulator
D8Z23_03290	COG0829	nickel cation binding
D8Z23_03295	COG0831	urea catabolic process
D8Z23_03305	COG0832	Belongs to the urease beta subunit family
D8Z23_03310	COG0804	urea catabolic process
D8Z23_03320	COG0830	nickel cation binding
D8Z23_03325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D8Z23_03345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_03350	COG0601	transmembrane transport
D8Z23_03355	COG0747	negative chemotaxis
D8Z23_03370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8Z23_03380	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D8Z23_03390	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D8Z23_03395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8Z23_03400	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D8Z23_03415	COG0438	transferase activity, transferring glycosyl groups
D8Z23_03430	COG0438	transferase activity, transferring glycosyl groups
D8Z23_03435	COG0438	transferase activity, transferring glycosyl groups
D8Z23_03440	COG0166	Belongs to the GPI family
D8Z23_03455	COG0277	FAD linked oxidase domain protein
D8Z23_03460	COG0745	RESPONSE REGULATOR receiver
D8Z23_03465	COG0642	Histidine kinase
D8Z23_03470	COG1368	sulfuric ester hydrolase activity
D8Z23_03480	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D8Z23_03505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D8Z23_03515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D8Z23_03520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D8Z23_03530	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D8Z23_03535	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D8Z23_03540	COG0193	aminoacyl-tRNA hydrolase activity
D8Z23_03550	COG0012	GTP binding
D8Z23_03555	COG0582	viral genome integration into host DNA
D8Z23_03580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D8Z23_03640	COG0745	RESPONSE REGULATOR receiver
D8Z23_03655	COG1309	transcriptional regulator
D8Z23_03685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_03695	COG0405	Gamma-glutamyltransferase
D8Z23_03770	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D8Z23_03775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8Z23_03785	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D8Z23_03790	COG0513	Belongs to the DEAD box helicase family
D8Z23_03800	COG0617	tRNA 3'-terminal CCA addition
D8Z23_03815	COG0477	Major facilitator Superfamily
D8Z23_03825	COG0583	DNA-binding transcription factor activity
D8Z23_03840	COG1950	PFAM Membrane protein of
D8Z23_03845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D8Z23_03860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D8Z23_03870	COG1560	Kdo2-lipid A biosynthetic process
D8Z23_03875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D8Z23_03885	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D8Z23_03895	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D8Z23_03905	COG0803	Belongs to the bacterial solute-binding protein 9 family
D8Z23_03915	COG1121	(ABC) transporter
D8Z23_03925	COG0735	belongs to the Fur family
D8Z23_03930	COG0523	cobalamin synthesis protein
D8Z23_03935	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D8Z23_03940	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D8Z23_03945	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D8Z23_03960	COG2096	Adenosyltransferase
D8Z23_03980	COG2084	Dehydrogenase
D8Z23_04030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D8Z23_04035	COG0129	dihydroxy-acid dehydratase activity
D8Z23_04040	COG4654	Cytochrome c, class I
D8Z23_04045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D8Z23_04055	COG1522	sequence-specific DNA binding
D8Z23_04095	COG1473	amidohydrolase
D8Z23_04100	COG0418	dihydroorotase activity
D8Z23_04115	COG2001	Belongs to the MraZ family
D8Z23_04120	COG0275	rRNA processing
D8Z23_04125	COG3116	cell division
D8Z23_04135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D8Z23_04140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8Z23_04145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D8Z23_04155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D8Z23_04160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8Z23_04165	COG1181	Belongs to the D-alanine--D-alanine ligase family
D8Z23_04170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D8Z23_04180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D8Z23_04185	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D8Z23_04195	COG0739	heme binding
D8Z23_04200	COG0653	protein targeting
D8Z23_04220	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_04225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_04230	COG1522	sequence-specific DNA binding
D8Z23_04250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D8Z23_04260	COG0557	exoribonuclease II activity
D8Z23_04265	COG3150	esterase
D8Z23_04270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8Z23_04275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8Z23_04280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D8Z23_04285	COG0511	ligase activity, forming carbon-carbon bonds
D8Z23_04290	COG0439	Biotin carboxylase
D8Z23_04330	COG1696	Membrane protein involved in D-alanine export
D8Z23_04335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8Z23_04370	COG1522	sequence-specific DNA binding
D8Z23_04385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8Z23_04390	COG0045	succinate-CoA ligase (ADP-forming) activity
D8Z23_04390	COG1042	CoA-binding domain protein
D8Z23_04390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D8Z23_04405	COG1802	Transcriptional regulator
D8Z23_04410	COG3069	C4-dicarboxylate transmembrane transporter activity
D8Z23_04415	COG0513	Belongs to the DEAD box helicase family
D8Z23_04420	COG0346	lactoylglutathione lyase activity
D8Z23_04425	COG1335	isochorismatase
D8Z23_04430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_04435	COG1116	anion transmembrane transporter activity
D8Z23_04450	COG3028	Belongs to the UPF0307 family
D8Z23_04455	COG0312	modulator of DNA gyrase
D8Z23_04460	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8Z23_04465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D8Z23_04470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D8Z23_04475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D8Z23_04485	COG0316	Belongs to the HesB IscA family
D8Z23_04490	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D8Z23_04505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D8Z23_04515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D8Z23_04520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D8Z23_04535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8Z23_04535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8Z23_04570	COG0583	DNA-binding transcription factor activity
D8Z23_04610	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D8Z23_04620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8Z23_04625	COG1845	cytochrome c oxidase, subunit III
D8Z23_04630	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D8Z23_04635	COG0640	Transcriptional regulator
D8Z23_04655	COG3220	belongs to the UPF0276 family
D8Z23_04730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D8Z23_04735	COG0312	modulator of DNA gyrase
D8Z23_04740	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D8Z23_04745	COG3064	Membrane
D8Z23_04745	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8Z23_04745	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8Z23_04745	COG3210	domain, Protein
D8Z23_04745	COG3210	domain, Protein
D8Z23_04745	COG3064	Membrane
D8Z23_04750	COG0277	FAD linked oxidase domain protein
D8Z23_04755	COG0277	FAD linked oxidase domain protein
D8Z23_04760	COG0277	FAD linked oxidase domain protein
D8Z23_04765	COG0247	lactate metabolic process
D8Z23_04770	COG2819	hydrolase of the alpha beta superfamily
D8Z23_04785	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D8Z23_04795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D8Z23_04810	COG0583	DNA-binding transcription factor activity
D8Z23_04815	COG0482	sulfurtransferase activity
D8Z23_04820	COG0730	response to heat
D8Z23_04825	COG0625	glutathione transferase activity
D8Z23_04830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D8Z23_04835	COG3909	cytochrome
D8Z23_04875	COG0154	amidase activity
D8Z23_04880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_04885	COG1024	Enoyl-CoA hydratase
D8Z23_04900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_04915	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_04920	COG1414	Transcriptional regulator
D8Z23_04930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8Z23_04935	COG0251	oxidation-reduction process
D8Z23_04940	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_04955	COG0410	ABC transporter
D8Z23_04975	COG0583	DNA-binding transcription factor activity
D8Z23_04985	COG0590	tRNA wobble adenosine to inosine editing
D8Z23_04990	COG2807	transmembrane transport
D8Z23_05010	COG0154	amidase activity
D8Z23_05015	COG0307	riboflavin synthase, alpha
D8Z23_05020	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_05025	COG1522	sequence-specific DNA binding
D8Z23_05035	COG0318	PFAM AMP-dependent synthetase and ligase
D8Z23_05045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_05065	COG1063	alcohol dehydrogenase
D8Z23_05090	COG1418	mRNA catabolic process
D8Z23_05095	COG1448	Aminotransferase
D8Z23_05100	COG0583	DNA-binding transcription factor activity
D8Z23_05110	COG0477	Major facilitator Superfamily
D8Z23_05115	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_05130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D8Z23_05135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D8Z23_05140	COG0583	DNA-binding transcription factor activity
D8Z23_05200	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_05205	COG1309	transcriptional regulator
D8Z23_05215	COG2982	Protein involved in outer membrane biogenesis
D8Z23_05220	COG2818	Glycosylase
D8Z23_05240	COG1653	transport
D8Z23_05255	COG3842	ATPase activity
D8Z23_05260	COG0395	ABC-type sugar transport system, permease component
D8Z23_05265	COG1175	transmembrane transport
D8Z23_05285	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_05290	COG2186	Transcriptional regulator
D8Z23_05315	COG1454	alcohol dehydrogenase
D8Z23_05335	COG2011	ABC-type metal ion transport system permease component
D8Z23_05340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D8Z23_05345	COG1501	Belongs to the glycosyl hydrolase 31 family
D8Z23_05370	COG0318	PFAM AMP-dependent synthetase and ligase
D8Z23_05375	COG1473	amidohydrolase
D8Z23_05385	COG2855	membrane
D8Z23_05390	COG1607	acyl-coa hydrolase
D8Z23_05395	COG2239	Acts as a magnesium transporter
D8Z23_05415	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_05425	COG1722	exodeoxyribonuclease VII activity
D8Z23_05430	COG0142	geranyltranstransferase activity
D8Z23_05435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D8Z23_05440	COG1469	GTP cyclohydrolase I activity
D8Z23_05445	COG0360	Binds together with S18 to 16S ribosomal RNA
D8Z23_05450	COG2965	DNA replication, synthesis of RNA primer
D8Z23_05455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D8Z23_05460	COG0359	binds to the 23S rRNA
D8Z23_05470	COG0305	Participates in initiation and elongation during chromosome replication
D8Z23_05480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D8Z23_05485	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D8Z23_05490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D8Z23_05495	COG3737	Protein of unknown function (DUF498/DUF598)
D8Z23_05500	COG0436	Aminotransferase
D8Z23_05525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D8Z23_05560	COG0268	Binds directly to 16S ribosomal RNA
D8Z23_05570	COG0728	peptidoglycan biosynthetic process
D8Z23_05580	COG0563	adenylate kinase activity
D8Z23_05585	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D8Z23_05590	COG2835	tetraacyldisaccharide 4'-kinase activity
D8Z23_05595	COG1663	tetraacyldisaccharide 4'-kinase activity
D8Z23_05600	COG0848	biopolymer transport protein
D8Z23_05605	COG0811	peptide transport
D8Z23_05615	COG1570	exodeoxyribonuclease VII activity
D8Z23_05620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D8Z23_05625	COG0038	chloride channel
D8Z23_05630	COG0183	Belongs to the thiolase family
D8Z23_05640	COG1278	Cold shock
D8Z23_05645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D8Z23_05655	COG4953	penicillin-binding protein 1C
D8Z23_05660	COG0542	response to heat
D8Z23_05665	COG2995	paraquat-inducible protein a
D8Z23_05670	COG3008	intermembrane lipid transfer
D8Z23_05670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D8Z23_05680	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D8Z23_05680	COG0506	proline dehydrogenase activity
D8Z23_05680	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D8Z23_05695	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_05715	COG2271	Major facilitator Superfamily
D8Z23_05720	COG1309	transcriptional regulator
D8Z23_05725	COG3468	outer membrane autotransporter barrel domain protein
D8Z23_05755	COG0477	Major facilitator Superfamily
D8Z23_05765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8Z23_05770	COG1845	cytochrome c oxidase, subunit III
D8Z23_05775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D8Z23_05785	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_05805	COG0789	Transcriptional regulator
D8Z23_05830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D8Z23_05835	COG0697	spore germination
D8Z23_05845	COG0678	peroxiredoxin activity
D8Z23_05855	COG0412	Dienelactone hydrolase
D8Z23_05865	COG0315	cyclic pyranopterin monophosphate synthase activity
D8Z23_05880	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8Z23_05885	COG0303	'Molybdopterin
D8Z23_05890	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D8Z23_05910	COG0165	Argininosuccinate lyase
D8Z23_05915	COG0668	transmembrane transport
D8Z23_05960	COG0747	negative chemotaxis
D8Z23_05965	COG0601	transmembrane transport
D8Z23_05980	COG1162	GTPase activity
D8Z23_05985	COG0501	Belongs to the peptidase M48B family
D8Z23_05990	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D8Z23_06000	COG3327	negative regulation of DNA-templated transcription, initiation
D8Z23_06005	COG3396	Phenylacetate-CoA oxygenase
D8Z23_06010	COG3460	Phenylacetate-CoA oxygenase
D8Z23_06015	COG3396	Phenylacetate-CoA oxygenase
D8Z23_06020	COG2151	metal-sulfur cluster biosynthetic enzyme
D8Z23_06040	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_06045	COG1024	Enoyl-CoA hydratase
D8Z23_06050	COG2050	protein possibly involved in aromatic compounds catabolism
D8Z23_06060	COG3539	Fimbrial protein
D8Z23_06080	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8Z23_06085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D8Z23_06090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D8Z23_06095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D8Z23_06095	COG0047	phosphoribosylformylglycinamidine synthase activity
D8Z23_06100	COG3064	Membrane
D8Z23_06100	COG3210	domain, Protein
D8Z23_06100	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8Z23_06130	COG0235	Class ii aldolase
D8Z23_06135	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8Z23_06140	COG0720	synthase
D8Z23_06145	COG0602	queuosine metabolic process
D8Z23_06170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8Z23_06200	COG1053	succinate dehydrogenase
D8Z23_06205	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_06230	COG3842	ATPase activity
D8Z23_06240	COG0395	ABC-type sugar transport system, permease component
D8Z23_06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_06275	COG0420	3'-5' exonuclease activity
D8Z23_06320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8Z23_06320	COG0519	Catalyzes the synthesis of GMP from XMP
D8Z23_06335	COG3550	peptidyl-serine autophosphorylation
D8Z23_06345	COG0477	Major facilitator Superfamily
D8Z23_06360	COG1228	amidohydrolase
D8Z23_06370	COG1116	anion transmembrane transporter activity
D8Z23_06375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_06410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D8Z23_06425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D8Z23_06455	COG2814	Major facilitator Superfamily
D8Z23_06470	COG1280	lysine exporter protein (LysE YggA)
D8Z23_06490	COG0747	negative chemotaxis
D8Z23_06495	COG0601	transmembrane transport
D8Z23_06505	COG4172	Belongs to the ABC transporter superfamily
D8Z23_06510	COG1609	Transcriptional regulator
D8Z23_06540	COG0586	Pfam SNARE associated Golgi protein
D8Z23_06555	COG0500	methyltransferase
D8Z23_06570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8Z23_06580	COG0756	dUTP diphosphatase activity
D8Z23_06595	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D8Z23_06600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D8Z23_06605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D8Z23_06610	COG0072	phenylalanine-tRNA ligase activity
D8Z23_06610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8Z23_06615	COG0776	regulation of translation
D8Z23_06680	COG0540	Belongs to the ATCase OTCase family
D8Z23_06685	COG2974	May be involved in recombination
D8Z23_06695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_06700	COG0583	DNA-binding transcription factor activity
D8Z23_06720	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_06735	COG3842	ATPase activity
D8Z23_06740	COG1024	Enoyl-CoA hydratase
D8Z23_06740	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8Z23_06750	COG0642	Histidine kinase
D8Z23_06760	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D8Z23_06765	COG2137	regulation of response to DNA damage stimulus
D8Z23_06770	COG0583	DNA-binding transcription factor activity
D8Z23_06775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D8Z23_06785	COG0045	succinate-CoA ligase (ADP-forming) activity
D8Z23_06790	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D8Z23_06795	COG0861	Integral membrane protein TerC family
D8Z23_06800	COG0861	Integral membrane protein TerC family
D8Z23_06805	COG0181	hydroxymethylbilane synthase activity
D8Z23_06825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D8Z23_06865	COG4964	Belongs to the GSP D family
D8Z23_06890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D8Z23_06900	COG0583	DNA-binding transcription factor activity
D8Z23_06910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_06915	COG4311	Sarcosine oxidase, delta subunit
D8Z23_06920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D8Z23_06920	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8Z23_06955	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D8Z23_06960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D8Z23_06965	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D8Z23_06970	COG0735	belongs to the Fur family
D8Z23_06975	COG0497	DNA recombination
D8Z23_06980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D8Z23_06985	COG1420	regulation of RNA biosynthetic process
D8Z23_06990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D8Z23_07000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D8Z23_07010	COG0443	Heat shock 70 kDa protein
D8Z23_07020	COG0612	Peptidase, M16
D8Z23_07040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8Z23_07085	COG0745	RESPONSE REGULATOR receiver
D8Z23_07095	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D8Z23_07100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D8Z23_07105	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D8Z23_07120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8Z23_07140	COG1193	negative regulation of DNA recombination
D8Z23_07145	COG0492	ferredoxin-NADP+ reductase activity
D8Z23_07150	COG1674	ftsk spoiiie
D8Z23_07155	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D8Z23_07160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D8Z23_07165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D8Z23_07190	COG3706	GGDEF domain
D8Z23_07210	COG2814	Major facilitator Superfamily
D8Z23_07255	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_07265	COG3022	response to hydroperoxide
D8Z23_07285	COG3706	GGDEF domain
D8Z23_07305	COG2197	response regulator
D8Z23_07310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D8Z23_07315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D8Z23_07320	COG0189	ligase activity
D8Z23_07330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8Z23_07335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D8Z23_07350	COG2423	ornithine cyclodeaminase activity
D8Z23_07360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_07365	COG0765	amino acid transport
D8Z23_07370	COG0765	amino acid transport
D8Z23_07375	COG1126	abc transporter atp-binding protein
D8Z23_07430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D8Z23_07440	COG2944	sequence-specific DNA binding
D8Z23_07450	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D8Z23_07455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D8Z23_07460	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D8Z23_07465	COG0009	L-threonylcarbamoyladenylate synthase
D8Z23_07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_07475	COG1414	Transcriptional regulator
D8Z23_07490	COG0765	amino acid transport
D8Z23_07495	COG1126	abc transporter atp-binding protein
D8Z23_07500	COG0028	Belongs to the TPP enzyme family
D8Z23_07515	COG0028	Belongs to the TPP enzyme family
D8Z23_07520	COG0583	DNA-binding transcription factor activity
D8Z23_07525	COG4974	Belongs to the 'phage' integrase family
D8Z23_07530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D8Z23_07535	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D8Z23_07550	COG1686	Belongs to the peptidase S11 family
D8Z23_07570	COG1074	ATP-dependent DNA helicase activity
D8Z23_07580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8Z23_07585	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D8Z23_07590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D8Z23_07610	COG2321	neutral zinc metallopeptidase
D8Z23_07615	COG0009	L-threonylcarbamoyladenylate synthase
D8Z23_07660	COG3360	Dodecin
D8Z23_07665	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D8Z23_07670	COG2850	peptidyl-arginine hydroxylation
D8Z23_07675	COG3539	Fimbrial protein
D8Z23_07680	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D8Z23_07685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8Z23_07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_07705	COG0765	amino acid transport
D8Z23_07710	COG1126	abc transporter atp-binding protein
D8Z23_07715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8Z23_07720	COG1758	RNA polymerase activity
D8Z23_07725	COG0194	GDP metabolic process
D8Z23_07730	COG3258	Cytochrome c
D8Z23_07735	COG2863	cytochrome
D8Z23_07740	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_07745	COG0791	NLP P60 protein
D8Z23_07750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D8Z23_07770	COG1561	YicC-like family, N-terminal region
D8Z23_07775	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D8Z23_07790	COG0840	transmembrane signaling receptor activity
D8Z23_07795	COG2200	EAL domain
D8Z23_07795	COG2199	diguanylate cyclase activity
D8Z23_07800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D8Z23_07810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D8Z23_07820	COG3852	Histidine kinase
D8Z23_07825	COG2204	response regulator
D8Z23_07830	COG0583	DNA-binding transcription factor activity
D8Z23_07835	COG1741	Belongs to the pirin family
D8Z23_07840	COG1741	Belongs to the pirin family
D8Z23_07850	COG3842	ATPase activity
D8Z23_07855	COG1178	ABC-type Fe3 transport system permease component
D8Z23_07860	COG1840	ABC-type Fe3 transport system, periplasmic component
D8Z23_07870	COG0583	DNA-binding transcription factor activity
D8Z23_07880	COG0656	L-ascorbic acid biosynthetic process
D8Z23_07895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D8Z23_07900	COG0583	DNA-binding transcription factor activity
D8Z23_07915	COG0783	Belongs to the Dps family
D8Z23_07935	COG0463	Glycosyl transferase, family 2
D8Z23_07955	COG0438	transferase activity, transferring glycosyl groups
D8Z23_07970	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D8Z23_07995	COG0300	oxidoreductase activity
D8Z23_08040	COG0861	Integral membrane protein TerC family
D8Z23_08045	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_08065	COG0714	Associated with various cellular activities
D8Z23_08100	COG3119	arylsulfatase activity
D8Z23_08125	COG2197	response regulator
D8Z23_08135	COG2944	sequence-specific DNA binding
D8Z23_08145	COG0625	glutathione transferase activity
D8Z23_08175	COG0179	Fumarylacetoacetate (FAA) hydrolase
D8Z23_08180	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_08225	COG0431	NADPH-dependent FMN reductase
D8Z23_08255	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_08260	COG0583	DNA-binding transcription factor activity
D8Z23_08280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8Z23_08280	COG2111	Na H antiporter
D8Z23_08285	COG1006	Multisubunit Na H antiporter MnhC subunit
D8Z23_08290	COG0651	ATP synthesis coupled electron transport
D8Z23_08295	COG1863	multisubunit Na H antiporter MnhE subunit
D8Z23_08300	COG2212	antiporter activity
D8Z23_08325	COG0590	tRNA wobble adenosine to inosine editing
D8Z23_08330	COG1619	proteins homologs of microcin C7 resistance protein MccF
D8Z23_08335	COG1024	Enoyl-CoA hydratase
D8Z23_08350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8Z23_08355	COG0488	(ABC) transporter
D8Z23_08390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8Z23_08390	COG1017	nitric oxide dioxygenase activity
D8Z23_08395	COG1959	2 iron, 2 sulfur cluster binding
D8Z23_08400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_08420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D8Z23_08425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D8Z23_08430	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8Z23_08435	COG0084	hydrolase, TatD family'
D8Z23_08450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_08460	COG1126	abc transporter atp-binding protein
D8Z23_08470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D8Z23_08485	COG0028	Belongs to the TPP enzyme family
D8Z23_08505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8Z23_08555	COG4336	lyase activity
D8Z23_08565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_08565	COG2205	protein histidine kinase activity
D8Z23_08570	COG2197	response regulator
D8Z23_08575	COG3064	Membrane
D8Z23_08575	COG3210	domain, Protein
D8Z23_08575	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D8Z23_08585	COG3121	Chaperone
D8Z23_08590	COG3188	usher protein
D8Z23_08595	COG3539	Fimbrial protein
D8Z23_08600	COG2831	hemolysin activation secretion protein
D8Z23_08615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8Z23_08665	COG0668	transmembrane transport
D8Z23_08690	COG1253	flavin adenine dinucleotide binding
D8Z23_08695	COG1968	undecaprenyl-diphosphatase activity
D8Z23_08700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8Z23_08715	COG0215	cysteine-tRNA ligase activity
D8Z23_08725	COG0825	malonyl-CoA metabolic process
D8Z23_08735	COG0037	tRNA processing
D8Z23_08740	COG0527	aspartate kinase activity
D8Z23_08765	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8Z23_08770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D8Z23_08785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8Z23_08790	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D8Z23_08795	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_08805	COG0583	DNA-binding transcription factor activity
D8Z23_08820	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8Z23_08830	COG3842	ATPase activity
D8Z23_08840	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8Z23_08840	COG1902	pentaerythritol trinitrate reductase activity
D8Z23_08845	COG1414	Transcriptional regulator
D8Z23_08850	COG1832	CoA-binding protein
D8Z23_08860	COG0251	oxidation-reduction process
D8Z23_08885	COG1902	pentaerythritol trinitrate reductase activity
D8Z23_08895	COG1215	transferase activity, transferring glycosyl groups
D8Z23_08900	COG1649	PFAM Uncharacterised BCR, COG1649
D8Z23_08900	COG0726	polysaccharide deacetylase
D8Z23_08920	COG1846	Transcriptional regulator
D8Z23_08925	COG2197	response regulator
D8Z23_08940	COG0166	Belongs to the GPI family
D8Z23_08945	COG1045	serine acetyltransferase
D8Z23_08955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D8Z23_08960	COG0483	inositol monophosphate 1-phosphatase activity
D8Z23_08965	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_08970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D8Z23_08985	COG0210	DNA helicase
D8Z23_08990	COG0598	Magnesium transport protein CorA
D8Z23_09000	COG0747	negative chemotaxis
D8Z23_09005	COG0601	transmembrane transport
D8Z23_09010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_09015	COG4172	Belongs to the ABC transporter superfamily
D8Z23_09020	COG1846	Transcriptional regulator
D8Z23_09075	COG4964	Belongs to the GSP D family
D8Z23_09115	COG2204	response regulator
D8Z23_09130	COG1595	DNA-templated transcription, initiation
D8Z23_09140	COG3474	cytochrome
D8Z23_09145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D8Z23_09160	COG3384	dioxygenase
D8Z23_09165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D8Z23_09195	COG2885	chlorophyll binding
D8Z23_09230	COG0697	spore germination
D8Z23_09235	COG0730	response to heat
D8Z23_09250	COG0583	DNA-binding transcription factor activity
D8Z23_09255	COG0427	acetyl-CoA hydrolase
D8Z23_09310	COG1250	3-hydroxyacyl-CoA dehydrogenase
D8Z23_09315	COG0154	amidase activity
D8Z23_09325	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D8Z23_09340	COG0495	leucyl-tRNA aminoacylation
D8Z23_09345	COG2814	Major facilitator Superfamily
D8Z23_09350	COG1846	Transcriptional regulator
D8Z23_09375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D8Z23_09380	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D8Z23_09385	COG2814	Major facilitator Superfamily
D8Z23_09405	COG4176	ABC-type proline glycine betaine transport system permease component
D8Z23_09415	COG1942	4-Oxalocrotonate Tautomerase
D8Z23_09420	COG0183	Belongs to the thiolase family
D8Z23_09430	COG1802	Transcriptional regulator
D8Z23_09440	COG1024	Enoyl-CoA hydratase
D8Z23_09455	COG2032	superoxide dismutase activity
D8Z23_09470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D8Z23_09495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8Z23_09500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8Z23_09510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D8Z23_09515	COG0736	holo-[acyl-carrier-protein] synthase activity
D8Z23_09520	COG1472	Belongs to the glycosyl hydrolase 3 family
D8Z23_09525	COG0322	excinuclease ABC activity
D8Z23_09530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D8Z23_09540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D8Z23_09540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D8Z23_09545	COG2224	Isocitrate lyase
D8Z23_09570	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_09580	COG4638	Rieske (2fe-2S)
D8Z23_09585	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D8Z23_09590	COG1024	Enoyl-CoA hydratase
D8Z23_09600	COG0633	Ferredoxin
D8Z23_09605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_09620	COG0183	Belongs to the thiolase family
D8Z23_09635	COG0583	DNA-binding transcription factor activity
D8Z23_09665	COG2346	COG2346, Truncated hemoglobins
D8Z23_09795	COG2207	Transcriptional regulator
D8Z23_09845	COG1132	(ABC) transporter
D8Z23_09870	COG0659	secondary active sulfate transmembrane transporter activity
D8Z23_09900	COG2169	Transcriptional regulator
D8Z23_09905	COG5507	3-demethylubiquinone-9 3-methyltransferase
D8Z23_09910	COG0384	phenazine biosynthesis protein PhzF
D8Z23_09915	COG0583	DNA-binding transcription factor activity
D8Z23_09920	COG2733	membrane
D8Z23_09935	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_09940	COG3284	Transcriptional regulator
D8Z23_09965	COG1380	Effector of murein hydrolase LrgA
D8Z23_09970	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D8Z23_09970	COG4106	trans-aconitate 2-methyltransferase activity
D8Z23_09980	COG0156	8-amino-7-oxononanoate synthase activity
D8Z23_10050	COG1131	(ABC) transporter
D8Z23_10055	COG0842	Transport permease protein
D8Z23_10060	COG0628	permease
D8Z23_10090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D8Z23_10100	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D8Z23_10110	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D8Z23_10115	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D8Z23_10120	COG0330	HflC and HflK could
D8Z23_10125	COG0330	HflC and HflK could
D8Z23_10130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D8Z23_10135	COG1923	regulation of RNA biosynthetic process
D8Z23_10140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D8Z23_10145	COG1160	GTP binding
D8Z23_10150	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D8Z23_10155	COG2976	Protein conserved in bacteria
D8Z23_10160	COG0124	histidyl-tRNA synthetase
D8Z23_10165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D8Z23_10175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D8Z23_10180	COG0105	UTP biosynthetic process
D8Z23_10185	COG0525	valine-tRNA ligase activity
D8Z23_10200	COG0642	Histidine kinase
D8Z23_10225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D8Z23_10230	COG0336	Belongs to the RNA methyltransferase TrmD family
D8Z23_10235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D8Z23_10240	COG0228	four-way junction DNA binding
D8Z23_10250	COG0425	Belongs to the sulfur carrier protein TusA family
D8Z23_10255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D8Z23_10300	COG0154	amidase activity
D8Z23_10305	COG4172	Belongs to the ABC transporter superfamily
D8Z23_10310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_10315	COG0601	transmembrane transport
D8Z23_10320	COG0747	negative chemotaxis
D8Z23_10350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_10360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D8Z23_10380	COG3395	kinase activity
D8Z23_10395	COG1024	Enoyl-CoA hydratase
D8Z23_10415	COG0633	Ferredoxin
D8Z23_10420	COG0443	Heat shock 70 kDa protein
D8Z23_10425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D8Z23_10430	COG0316	Belongs to the HesB IscA family
D8Z23_10435	COG0822	iron-sulfur transferase activity
D8Z23_10440	COG1104	cysteine desulfurase activity
D8Z23_10450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8Z23_10455	COG0556	nucleotide-excision repair
D8Z23_10465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D8Z23_10495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D8Z23_10515	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_10520	COG0183	Belongs to the thiolase family
D8Z23_10530	COG1024	Enoyl-CoA hydratase
D8Z23_10545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_10550	COG0583	DNA-binding transcription factor activity
D8Z23_10555	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D8Z23_10560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D8Z23_10565	COG0740	serine-type endopeptidase activity
D8Z23_10570	COG0544	peptidyl-prolyl cis-trans isomerase activity
D8Z23_10580	COG1278	Cold shock
D8Z23_10590	COG1278	Cold shock
D8Z23_10625	COG2171	N-acyltransferase activity
D8Z23_10630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8Z23_10635	COG2890	protein-(glutamine-N5) methyltransferase activity
D8Z23_10640	COG0488	(ABC) transporter
D8Z23_10645	COG4771	TonB-dependent receptor
D8Z23_10650	COG0210	DNA helicase
D8Z23_10670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D8Z23_10675	COG0196	riboflavin kinase activity
D8Z23_10680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D8Z23_10685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D8Z23_10690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D8Z23_10700	COG1522	sequence-specific DNA binding
D8Z23_10720	COG2951	lytic endotransglycosylase activity
D8Z23_10725	COG2833	Protein of unknown function (DUF455)
D8Z23_10755	COG3237	CsbD-like
D8Z23_10765	COG2823	Periplasmic or secreted lipoprotein
D8Z23_10780	COG4181	ATPase activity
D8Z23_10790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8Z23_10795	COG0584	glycerophosphoryl diester phosphodiesterase
D8Z23_10800	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D8Z23_10810	COG0678	peroxiredoxin activity
D8Z23_10810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D8Z23_10820	COG0789	Transcriptional regulator
D8Z23_10825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D8Z23_10850	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D8Z23_10855	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D8Z23_10860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D8Z23_10870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D8Z23_10875	COG2252	PERMEase
D8Z23_10885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8Z23_10915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8Z23_10955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8Z23_10960	COG1366	Belongs to the anti-sigma-factor antagonist family
D8Z23_10965	COG2172	sigma factor antagonist activity
D8Z23_10970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D8Z23_10980	COG2770	Histidine kinase
D8Z23_10980	COG2208	phosphoserine phosphatase activity
D8Z23_11005	COG1595	DNA-templated transcription, initiation
D8Z23_11020	COG4792	protein secretion
D8Z23_11025	COG4791	protein targeting
D8Z23_11030	COG4794	Type iii secretion
D8Z23_11035	COG4790	Type iii secretion
D8Z23_11040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D8Z23_11070	COG4669	(LipO)protein
D8Z23_11135	COG4789	Type iii secretion
D8Z23_11165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D8Z23_11170	COG0840	transmembrane signaling receptor activity
D8Z23_11175	COG2233	PERMEase
D8Z23_11200	COG1840	ABC-type Fe3 transport system, periplasmic component
D8Z23_11205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D8Z23_11210	COG1178	ABC-type Fe3 transport system permease component
D8Z23_11215	COG3842	ATPase activity
D8Z23_11220	COG0583	DNA-binding transcription factor activity
D8Z23_11240	COG0501	Belongs to the peptidase M48B family
D8Z23_11250	COG0697	spore germination
D8Z23_11260	COG1846	Transcriptional regulator
D8Z23_11270	COG1566	PFAM secretion protein HlyD family protein
D8Z23_11275	COG2814	Major facilitator Superfamily
D8Z23_11280	COG0473	3-isopropylmalate dehydrogenase activity
D8Z23_11290	COG0747	negative chemotaxis
D8Z23_11300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_11315	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D8Z23_11340	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_11350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8Z23_11355	COG1115	amino acid carrier protein
D8Z23_11360	COG0433	COG0433 Predicted ATPase
D8Z23_11365	COG0217	transcriptional regulatory protein
D8Z23_11370	COG0151	Belongs to the GarS family
D8Z23_11375	COG0408	coproporphyrinogen oxidase activity
D8Z23_11380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D8Z23_11385	COG0799	negative regulation of ribosome biogenesis
D8Z23_11390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D8Z23_11395	COG0424	maF-like protein
D8Z23_11400	COG3468	outer membrane autotransporter barrel domain protein
D8Z23_11440	COG1530	ribonuclease E activity
D8Z23_11445	COG0077	Prephenate dehydratase
D8Z23_11460	COG1132	(ABC) transporter
D8Z23_11465	COG0859	PFAM glycosyl transferase family 9
D8Z23_11490	COG2194	sulfuric ester hydrolase activity
D8Z23_11495	COG0438	transferase activity, transferring glycosyl groups
D8Z23_11500	COG0463	Glycosyl transferase, family 2
D8Z23_11505	COG0726	polysaccharide deacetylase
D8Z23_11510	COG0438	transferase activity, transferring glycosyl groups
D8Z23_11525	COG1643	Atp-dependent helicase
D8Z23_11530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D8Z23_11530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D8Z23_11535	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D8Z23_11545	COG0704	Plays a role in the regulation of phosphate uptake
D8Z23_11550	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D8Z23_11555	COG1960	acyl-CoA dehydrogenase activity
D8Z23_11570	COG2094	Belongs to the DNA glycosylase MPG family
D8Z23_11580	COG1177	transmembrane transport
D8Z23_11585	COG1176	ABC-type spermidine putrescine transport system, permease component I
D8Z23_11590	COG3842	ATPase activity
D8Z23_11595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D8Z23_11600	COG3642	lipopolysaccharide core region biosynthetic process
D8Z23_11610	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D8Z23_11615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D8Z23_11640	COG0372	Belongs to the citrate synthase family
D8Z23_11645	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D8Z23_11650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D8Z23_11655	COG1053	succinate dehydrogenase
D8Z23_11660	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D8Z23_11665	COG2009	succinate dehydrogenase
D8Z23_11670	COG2188	Transcriptional regulator
D8Z23_11675	COG0039	L-malate dehydrogenase activity
D8Z23_11730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8Z23_11740	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D8Z23_11770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D8Z23_11775	COG0148	phosphopyruvate hydratase activity
D8Z23_11790	COG0504	CTP synthase activity
D8Z23_11815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_11825	COG0747	negative chemotaxis
D8Z23_11830	COG4172	Belongs to the ABC transporter superfamily
D8Z23_11835	COG1446	asparaginase
D8Z23_11865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8Z23_11880	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D8Z23_11885	COG0697	spore germination
D8Z23_11890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8Z23_11900	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D8Z23_11910	COG0791	NLP P60 protein
D8Z23_11925	COG0583	DNA-binding transcription factor activity
D8Z23_11940	COG0583	DNA-binding transcription factor activity
D8Z23_11950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D8Z23_11965	COG0670	Belongs to the BI1 family
D8Z23_11970	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_11985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D8Z23_11995	COG1381	Involved in DNA repair and RecF pathway recombination
D8Z23_12000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D8Z23_12005	COG0571	ribonuclease III activity
D8Z23_12010	COG0681	Belongs to the peptidase S26 family
D8Z23_12015	COG0481	GTPase activity
D8Z23_12020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8Z23_12045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D8Z23_12050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8Z23_12065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8Z23_12070	COG0416	fatty acid biosynthetic process
D8Z23_12075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D8Z23_12080	COG1399	metal-binding, possibly nucleic acid-binding protein
D8Z23_12085	COG0424	maF-like protein
D8Z23_12095	COG3023	N-Acetylmuramoyl-L-alanine amidase
D8Z23_12110	COG3022	response to hydroperoxide
D8Z23_12125	COG0135	phosphoribosylanthranilate isomerase activity
D8Z23_12140	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8Z23_12145	COG0101	tRNA pseudouridine synthase activity
D8Z23_12155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D8Z23_12160	COG0473	3-isopropylmalate dehydrogenase activity
D8Z23_12165	COG0066	3-isopropylmalate dehydratase activity
D8Z23_12170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D8Z23_12180	COG1122	ATPase activity
D8Z23_12215	COG3383	formate dehydrogenase (NAD+) activity
D8Z23_12215	COG0243	molybdopterin cofactor binding
D8Z23_12245	COG0489	protein tyrosine kinase activity
D8Z23_12250	COG0746	molybdenum cofactor guanylyltransferase activity
D8Z23_12255	COG0303	'Molybdopterin
D8Z23_12260	COG1763	Mo-molybdopterin cofactor biosynthetic process
D8Z23_12265	COG4783	chaperone-mediated protein folding
D8Z23_12270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D8Z23_12275	COG5001	Diguanylate cyclase
D8Z23_12295	COG3842	ATPase activity
D8Z23_12305	COG0406	alpha-ribazole phosphatase activity
D8Z23_12315	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D8Z23_12320	COG0505	Belongs to the CarA family
D8Z23_12325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D8Z23_12365	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D8Z23_12370	COG1960	acyl-CoA dehydrogenase activity
D8Z23_12380	COG2867	negative regulation of translational initiation
D8Z23_12390	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D8Z23_12395	COG3706	GGDEF domain
D8Z23_12400	COG0330	HflC and HflK could
D8Z23_12415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8Z23_12415	COG0519	Catalyzes the synthesis of GMP from XMP
D8Z23_12425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D8Z23_12430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8Z23_12435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D8Z23_12440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8Z23_12450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D8Z23_12455	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D8Z23_12460	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
D8Z23_12465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D8Z23_12470	COG0750	zinc metalloprotease
D8Z23_12475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D8Z23_12485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D8Z23_12490	COG0233	cytoplasmic translational termination
D8Z23_12495	COG0528	UMP kinase activity
D8Z23_12500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D8Z23_12505	COG0052	Belongs to the universal ribosomal protein uS2 family
D8Z23_12510	COG0024	Methionine aminopeptidase
D8Z23_12515	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D8Z23_12545	COG0285	dihydrofolate synthase activity
D8Z23_12580	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D8Z23_12590	COG1677	Flagellar hook-basal body complex protein FliE
D8Z23_12600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D8Z23_12610	COG1157	protein secretion by the type III secretion system
D8Z23_12635	COG1580	Controls the rotational direction of flagella during chemotaxis
D8Z23_12655	COG1338	Plays a role in the flagellum-specific transport system
D8Z23_12675	COG0840	transmembrane signaling receptor activity
D8Z23_12680	COG0840	transmembrane signaling receptor activity
D8Z23_12685	COG0840	transmembrane signaling receptor activity
D8Z23_12695	COG1256	bacterial-type flagellum assembly
D8Z23_12705	COG1706	bacterial-type flagellum-dependent cell motility
D8Z23_12710	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D8Z23_12715	COG4786	Flagellar basal body rod
D8Z23_12725	COG1749	Flagellar hook protein flgE
D8Z23_12730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D8Z23_12735	COG1558	bacterial-type flagellum-dependent cell motility
D8Z23_12740	COG1815	bacterial-type flagellum-dependent cell motility
D8Z23_12780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_12790	COG1126	abc transporter atp-binding protein
D8Z23_12805	COG4948	Mandelate Racemase Muconate Lactonizing
D8Z23_12810	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_12820	COG0066	3-isopropylmalate dehydratase activity
D8Z23_12835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_12845	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_12855	COG1802	Transcriptional regulator
D8Z23_12870	COG0583	DNA-binding transcription factor activity
D8Z23_12890	COG1695	Transcriptional regulator
D8Z23_12900	COG3568	Endonuclease Exonuclease Phosphatase
D8Z23_12905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8Z23_12955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D8Z23_12965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D8Z23_12985	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D8Z23_13015	COG0667	Aldo Keto reductase
D8Z23_13030	COG2259	Doxx family
D8Z23_13060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_13080	COG0386	Belongs to the glutathione peroxidase family
D8Z23_13085	COG0625	glutathione transferase activity
D8Z23_13100	COG0095	Lipoate-protein ligase
D8Z23_13140	COG2363	Small membrane protein
D8Z23_13165	COG3842	ATPase activity
D8Z23_13170	COG0395	ABC-type sugar transport system, permease component
D8Z23_13175	COG1175	transmembrane transport
D8Z23_13180	COG1653	transport
D8Z23_13190	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D8Z23_13205	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_13225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D8Z23_13250	COG2311	Membrane
D8Z23_13265	COG0187	DNA topoisomerase II activity
D8Z23_13275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D8Z23_13285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D8Z23_13290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D8Z23_13295	COG1760	l-serine dehydratase
D8Z23_13300	COG1283	sodium-dependent phosphate transmembrane transporter activity
D8Z23_13305	COG0412	Dienelactone hydrolase
D8Z23_13320	COG1611	Belongs to the LOG family
D8Z23_13340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D8Z23_13345	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D8Z23_13350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D8Z23_13355	COG2251	uridine kinase activity
D8Z23_13355	COG0195	Participates in both transcription termination and antitermination
D8Z23_13360	COG0779	Required for maturation of 30S ribosomal subunits
D8Z23_13365	COG1187	pseudouridine synthase activity
D8Z23_13370	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D8Z23_13380	COG0583	DNA-binding transcription factor activity
D8Z23_13390	COG0523	cobalamin synthesis protein
D8Z23_13410	COG0625	glutathione transferase activity
D8Z23_13420	COG1047	Peptidyl-prolyl cis-trans
D8Z23_13425	COG2003	Belongs to the UPF0758 family
D8Z23_13430	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D8Z23_13435	COG3483	tryptophan 2,3-dioxygenase activity
D8Z23_13440	COG0254	rRNA binding
D8Z23_13450	COG0534	Mate efflux family protein
D8Z23_13470	COG2304	oxidoreductase activity
D8Z23_13490	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_13495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D8Z23_13500	COG1562	ergosterol biosynthetic process
D8Z23_13505	COG1562	ergosterol biosynthetic process
D8Z23_13510	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D8Z23_13510	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D8Z23_13515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D8Z23_13525	COG0842	Transport permease protein
D8Z23_13530	COG1131	(ABC) transporter
D8Z23_13550	COG1477	protein flavinylation
D8Z23_13565	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D8Z23_13580	COG5564	TIM-barrel signal transduction protein
D8Z23_13585	COG5441	Belongs to the UPF0261 family
D8Z23_13595	COG3468	outer membrane autotransporter barrel domain protein
D8Z23_13615	COG0542	response to heat
D8Z23_13620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8Z23_13635	COG0494	nUDIX hydrolase
D8Z23_13640	COG3530	Putative quorum-sensing-regulated virulence factor
D8Z23_13650	COG1595	DNA-templated transcription, initiation
D8Z23_13655	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8Z23_13690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_13695	COG0765	amino acid transport
D8Z23_13700	COG0765	amino acid transport
D8Z23_13730	COG2988	succinylglutamate desuccinylase activity
D8Z23_13755	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_13760	COG2084	Dehydrogenase
D8Z23_13775	COG1619	proteins homologs of microcin C7 resistance protein MccF
D8Z23_13790	COG2814	Major facilitator Superfamily
D8Z23_13800	COG0583	DNA-binding transcription factor activity
D8Z23_13855	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D8Z23_13860	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_13865	COG3243	poly(R)-hydroxyalkanoic acid synthase
D8Z23_13875	COG0564	pseudouridine synthase activity
D8Z23_13885	COG1199	ATP-dependent helicase activity
D8Z23_13890	COG2183	response to ionizing radiation
D8Z23_13895	COG0180	Tryptophanyl-tRNA synthetase
D8Z23_13920	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_13930	COG0583	DNA-binding transcription factor activity
D8Z23_13935	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_13940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D8Z23_13945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8Z23_13950	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8Z23_13955	COG0567	Dehydrogenase, E1 component
D8Z23_13965	COG1522	sequence-specific DNA binding
D8Z23_13975	COG0280	phosphate acetyltransferase
D8Z23_13975	COG0281	malic enzyme
D8Z23_13980	COG3539	Fimbrial protein
D8Z23_14000	COG0613	PHP domain protein
D8Z23_14010	COG2333	competence protein COMEC
D8Z23_14010	COG0658	competence protein
D8Z23_14035	COG0084	hydrolase, TatD family'
D8Z23_14040	COG1136	(ABC) transporter
D8Z23_14055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D8Z23_14065	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_14070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D8Z23_14085	COG1022	Amp-dependent synthetase and ligase
D8Z23_14120	COG2205	protein histidine kinase activity
D8Z23_14125	COG0745	RESPONSE REGULATOR receiver
D8Z23_14130	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D8Z23_14140	COG1295	ribonuclease BN
D8Z23_14155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D8Z23_14185	COG1534	Rna-binding protein
D8Z23_14190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D8Z23_14195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8Z23_14205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8Z23_14215	COG0248	Ppx GppA phosphatase
D8Z23_14240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D8Z23_14255	COG2732	(Barnase) inhibitor
D8Z23_14265	COG0281	malic enzyme
D8Z23_14265	COG0280	phosphate acetyltransferase
D8Z23_14275	COG0436	Aminotransferase
D8Z23_14285	COG0741	lytic transglycosylase activity
D8Z23_14290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D8Z23_14315	COG1648	precorrin-2 dehydrogenase activity
D8Z23_14315	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D8Z23_14320	COG3468	outer membrane autotransporter barrel domain protein
D8Z23_14330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D8Z23_14335	COG2027	D-alanyl-D-alanine carboxypeptidase
D8Z23_14340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D8Z23_14345	COG0343	queuine tRNA-ribosyltransferase activity
D8Z23_14350	COG1862	Preprotein translocase
D8Z23_14355	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8Z23_14360	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8Z23_14375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D8Z23_14380	COG1702	phosphate starvation-inducible protein PhoH
D8Z23_14385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D8Z23_14390	COG4535	Mg2 and Co2 transporter CorC
D8Z23_14400	COG0667	Aldo Keto reductase
D8Z23_14425	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D8Z23_14430	COG0745	RESPONSE REGULATOR receiver
D8Z23_14435	COG2201	protein-glutamate methylesterase activity
D8Z23_14445	COG0840	transmembrane signaling receptor activity
D8Z23_14450	COG0835	chemotaxis
D8Z23_14455	COG2198	Histidine kinase
D8Z23_14455	COG0643	Histidine kinase
D8Z23_14485	COG1191	sigma factor activity
D8Z23_14495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D8Z23_14505	COG0739	heme binding
D8Z23_14515	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8Z23_14525	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D8Z23_14555	COG0625	glutathione transferase activity
D8Z23_14570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D8Z23_14575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D8Z23_14580	COG0126	phosphoglycerate kinase activity
D8Z23_14585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D8Z23_14590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D8Z23_14595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D8Z23_14605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D8Z23_14610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8Z23_14615	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8Z23_14620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D8Z23_14630	COG4566	intracellular signal transduction
D8Z23_14640	COG0339	signal peptide processing
D8Z23_14645	COG1999	signal sequence binding
D8Z23_14655	COG1538	Outer membrane efflux protein
D8Z23_14675	COG1187	pseudouridine synthase activity
D8Z23_14680	COG3161	chorismate lyase activity
D8Z23_14695	COG0667	Aldo Keto reductase
D8Z23_14710	COG0335	large ribosomal subunit rRNA binding
D8Z23_14745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D8Z23_14765	COG0450	alkyl hydroperoxide reductase
D8Z23_14770	COG1960	acyl-CoA dehydrogenase activity
D8Z23_14785	COG0123	including yeast histone deacetylase and acetoin utilization protein
D8Z23_14790	COG2951	lytic endotransglycosylase activity
D8Z23_14805	COG1555	photosystem II stabilization
D8Z23_14805	COG1596	polysaccharide export
D8Z23_14810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8Z23_14815	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D8Z23_14820	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D8Z23_14840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D8Z23_14845	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D8Z23_14850	COG0287	Prephenate dehydrogenase
D8Z23_14860	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D8Z23_14875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D8Z23_14885	COG2814	Major facilitator Superfamily
D8Z23_14915	COG0583	DNA-binding transcription factor activity
D8Z23_14955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D8Z23_14970	COG0667	Aldo Keto reductase
D8Z23_14980	COG5265	(ABC) transporter
D8Z23_15030	COG0439	Biotin carboxylase
D8Z23_15035	COG2188	Transcriptional regulator
D8Z23_15060	COG0511	ligase activity, forming carbon-carbon bonds
D8Z23_15070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D8Z23_15090	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D8Z23_15110	COG0500	methyltransferase
D8Z23_15115	COG5265	(ABC) transporter
D8Z23_15130	COG0028	Belongs to the TPP enzyme family
D8Z23_15135	COG0440	acetolactate synthase activity
D8Z23_15140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D8Z23_15145	COG1183	phosphatidylcholine synthase activity
D8Z23_15160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D8Z23_15180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D8Z23_15200	COG0149	triose-phosphate isomerase activity
D8Z23_15205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D8Z23_15215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8Z23_15225	COG3799	methylaspartate ammonia-lyase activity
D8Z23_15260	COG0583	DNA-binding transcription factor activity
D8Z23_15265	COG0626	cystathionine gamma-synthase activity
D8Z23_15270	COG3608	succinylglutamate desuccinylase aspartoacylase
D8Z23_15290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_15310	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D8Z23_15325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8Z23_15330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8Z23_15335	COG1733	regulation of RNA biosynthetic process
D8Z23_15350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8Z23_15355	COG0583	DNA-binding transcription factor activity
D8Z23_15360	COG1597	lipid kinase activity
D8Z23_15370	COG0671	phosphoesterase, PA-phosphatase related
D8Z23_15395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D8Z23_15400	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8Z23_15405	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8Z23_15410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8Z23_15415	COG0649	NAD binding
D8Z23_15420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D8Z23_15430	COG1034	ATP synthesis coupled electron transport
D8Z23_15435	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D8Z23_15440	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D8Z23_15450	COG0713	ATP synthesis coupled electron transport
D8Z23_15465	COG1007	ATP synthesis coupled electron transport
D8Z23_15475	COG4774	siderophore transport
D8Z23_15480	COG4774	siderophore transport
D8Z23_15495	COG0028	Belongs to the TPP enzyme family
D8Z23_15500	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_15505	COG0583	DNA-binding transcription factor activity
D8Z23_15510	COG0560	Phosphoserine phosphatase
D8Z23_15515	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D8Z23_15520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D8Z23_15540	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D8Z23_15545	COG0308	aminopeptidase N
D8Z23_15565	COG0028	Belongs to the TPP enzyme family
D8Z23_15575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D8Z23_15585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_15595	COG0318	PFAM AMP-dependent synthetase and ligase
D8Z23_15605	COG1802	Transcriptional regulator
D8Z23_15615	COG1802	Transcriptional regulator
D8Z23_15625	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_15645	COG1126	abc transporter atp-binding protein
D8Z23_15650	COG0765	amino acid transport
D8Z23_15670	COG1538	Outer membrane efflux protein
D8Z23_15675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D8Z23_15680	COG2274	protein secretion by the type I secretion system
D8Z23_15685	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D8Z23_15695	COG2994	toxin metabolic process
D8Z23_15715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_15720	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
D8Z23_15730	COG0583	DNA-binding transcription factor activity
D8Z23_15740	COG0142	geranyltranstransferase activity
D8Z23_15750	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D8Z23_15755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D8Z23_15760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D8Z23_15765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D8Z23_15815	COG3712	iron ion homeostasis
D8Z23_15820	COG4774	siderophore transport
D8Z23_15825	COG2353	YceI-like domain
D8Z23_15840	COG0019	diaminopimelate decarboxylase activity
D8Z23_15860	COG0747	negative chemotaxis
D8Z23_15865	COG0601	transmembrane transport
D8Z23_15870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_15880	COG0154	amidase activity
D8Z23_15885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8Z23_15910	COG2154	pterin-4-alpha-carbinolamine dehydratase
D8Z23_15920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D8Z23_15930	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D8Z23_15935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8Z23_15940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D8Z23_15945	COG1929	Belongs to the glycerate kinase type-1 family
D8Z23_15950	COG0469	pyruvate kinase activity
D8Z23_15955	COG0700	Nucleoside recognition
D8Z23_15990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D8Z23_15995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8Z23_16010	COG0823	Involved in the tonB-independent uptake of proteins
D8Z23_16020	COG0848	biopolymer transport protein
D8Z23_16025	COG0811	peptide transport
D8Z23_16030	COG0824	Thioesterase
D8Z23_16035	COG0442	prolyl-tRNA aminoacylation
D8Z23_16040	COG0494	nUDIX hydrolase
D8Z23_16055	COG2135	peptidase activity
D8Z23_16125	COG1196	nuclear chromosome segregation
D8Z23_16275	COG1464	Belongs to the NlpA lipoprotein family
D8Z23_16290	COG0410	ABC transporter
D8Z23_16305	COG4211	Belongs to the binding-protein-dependent transport system permease family
D8Z23_16310	COG0683	leucine binding
D8Z23_16315	COG0154	amidase activity
D8Z23_16320	COG0288	reversible hydration of carbon dioxide
D8Z23_16335	COG0514	ATP-dependent DNA helicase (RecQ)
D8Z23_16340	COG2255	four-way junction helicase activity
D8Z23_16355	COG0632	four-way junction helicase activity
D8Z23_16360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D8Z23_16380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D8Z23_16390	COG0006	proline dipeptidase activity
D8Z23_16415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D8Z23_16430	COG4783	chaperone-mediated protein folding
D8Z23_16435	COG0429	hydrolase of the alpha beta-hydrolase fold
D8Z23_16465	COG0513	Belongs to the DEAD box helicase family
D8Z23_16485	COG1058	Belongs to the CinA family
D8Z23_16485	COG1546	Belongs to the CinA family
D8Z23_16490	COG1414	Transcriptional regulator
D8Z23_16510	COG0167	dihydroorotate dehydrogenase activity
D8Z23_16515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D8Z23_16530	COG0583	DNA-binding transcription factor activity
D8Z23_16590	COG0281	malic enzyme
D8Z23_16590	COG0280	phosphate acetyltransferase
D8Z23_16600	COG0601	transmembrane transport
D8Z23_16605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_16610	COG4172	Belongs to the ABC transporter superfamily
D8Z23_16640	COG0640	Transcriptional regulator
D8Z23_16655	COG3135	benzoate transporter
D8Z23_16660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D8Z23_16665	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D8Z23_16670	COG0742	ribosomal rna small subunit methyltransferase
D8Z23_16685	COG3639	organic phosphonate transmembrane transporter activity
D8Z23_16690	COG3639	organic phosphonate transmembrane transporter activity
D8Z23_16730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D8Z23_16735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8Z23_16745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D8Z23_16750	COG1546	Belongs to the CinA family
D8Z23_16750	COG1058	Belongs to the CinA family
D8Z23_16755	COG0284	orotidine-5'-phosphate decarboxylase activity
D8Z23_16760	COG1252	NADH dehydrogenase
D8Z23_16775	COG3468	outer membrane autotransporter barrel domain protein
D8Z23_16780	COG0459	protein refolding
D8Z23_16785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D8Z23_16805	COG1053	succinate dehydrogenase
D8Z23_16815	COG0583	DNA-binding transcription factor activity
D8Z23_16845	COG3706	GGDEF domain
D8Z23_16885	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D8Z23_16895	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8Z23_16905	COG0069	glutamate synthase activity
D8Z23_16910	COG2391	methyltransferase activity
D8Z23_16915	COG0679	Auxin Efflux Carrier
D8Z23_16920	COG2153	protein acetylation
D8Z23_16940	COG0557	exoribonuclease II activity
D8Z23_16945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8Z23_16955	COG3128	pkhd-type hydroxylase
D8Z23_16960	COG0776	regulation of translation
D8Z23_16985	COG0745	RESPONSE REGULATOR receiver
D8Z23_16990	COG0642	Histidine kinase
D8Z23_16995	COG3158	transport of potassium into the cell
D8Z23_17000	COG0137	argininosuccinate synthase activity
D8Z23_17005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D8Z23_17010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8Z23_17020	COG0583	DNA-binding transcription factor activity
D8Z23_17030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D8Z23_17050	COG2186	Transcriptional regulator
D8Z23_17070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8Z23_17075	COG0450	alkyl hydroperoxide reductase
D8Z23_17080	COG2205	protein histidine kinase activity
D8Z23_17090	COG0745	RESPONSE REGULATOR receiver
D8Z23_17095	COG1214	PFAM Peptidase M22, glycoprotease
D8Z23_17100	COG1573	uracil-dna glycosylase
D8Z23_17105	COG0477	Major facilitator Superfamily
D8Z23_17110	COG1196	nuclear chromosome segregation
D8Z23_17120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D8Z23_17140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D8Z23_17145	COG1122	ATPase activity
D8Z23_17150	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D8Z23_17155	COG1268	BioY protein
D8Z23_17170	COG0411	ABC transporter
D8Z23_17175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8Z23_17190	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_17205	COG0411	ABC transporter
D8Z23_17210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D8Z23_17215	COG2878	Part of a membrane complex involved in electron transport
D8Z23_17230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D8Z23_17235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D8Z23_17240	COG0251	oxidation-reduction process
D8Z23_17250	COG3228	Belongs to the MtfA family
D8Z23_17255	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D8Z23_17265	COG0133	tryptophan synthase activity
D8Z23_17270	COG0159	tryptophan synthase activity
D8Z23_17295	COG1530	ribonuclease E activity
D8Z23_17305	COG0546	phosphoglycolate phosphatase activity
D8Z23_17310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D8Z23_17315	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D8Z23_17325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_17330	COG0583	DNA-binding transcription factor activity
D8Z23_17340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_17360	COG0251	oxidation-reduction process
D8Z23_17365	COG1017	nitric oxide dioxygenase activity
D8Z23_17365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8Z23_17370	COG2031	fatty acid transporter
D8Z23_17375	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_17380	COG1802	Transcriptional regulator
D8Z23_17390	COG1278	Cold shock
D8Z23_17395	COG0583	DNA-binding transcription factor activity
D8Z23_17420	COG0183	Belongs to the thiolase family
D8Z23_17430	COG1960	acyl-CoA dehydrogenase activity
D8Z23_17435	COG0583	DNA-binding transcription factor activity
D8Z23_17440	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_17445	COG1024	Enoyl-CoA hydratase
D8Z23_17450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_17455	COG1253	flavin adenine dinucleotide binding
D8Z23_17460	COG1285	pathogenesis
D8Z23_17470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8Z23_17485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D8Z23_17495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8Z23_17505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_17510	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_17515	COG1960	acyl-CoA dehydrogenase activity
D8Z23_17535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D8Z23_17540	COG1024	Enoyl-CoA hydratase
D8Z23_17545	COG1960	acyl-CoA dehydrogenase activity
D8Z23_17565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D8Z23_17570	COG0022	dehydrogenase e1 component
D8Z23_17575	COG1024	Enoyl-CoA hydratase
D8Z23_17580	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8Z23_17600	COG0683	leucine binding
D8Z23_17605	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_17610	COG0411	ABC transporter
D8Z23_17615	COG0410	ABC transporter
D8Z23_17620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8Z23_17635	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_17665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D8Z23_17670	COG0793	Belongs to the peptidase S41A family
D8Z23_17675	COG4942	peptidase
D8Z23_17680	COG0588	phosphoglycerate mutase activity
D8Z23_17690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D8Z23_17695	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D8Z23_17700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D8Z23_17705	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_17720	COG2226	methyltransferase
D8Z23_17725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D8Z23_17740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_17745	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8Z23_17770	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D8Z23_17795	COG1335	isochorismatase
D8Z23_17800	COG2309	aminopeptidase activity
D8Z23_17810	COG3473	Maleate cis-trans isomerase
D8Z23_17820	COG2068	MobA-Related Protein
D8Z23_17840	COG0569	domain protein
D8Z23_17845	COG2204	response regulator
D8Z23_17850	COG5000	phosphorelay sensor kinase activity
D8Z23_17860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D8Z23_17860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8Z23_17870	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D8Z23_17905	COG0583	DNA-binding transcription factor activity
D8Z23_17925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8Z23_17930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_17945	COG0758	DNA mediated transformation
D8Z23_17950	COG1522	sequence-specific DNA binding
D8Z23_17960	COG0242	peptide deformylase activity
D8Z23_17975	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D8Z23_17985	COG0546	phosphoglycolate phosphatase activity
D8Z23_18010	COG1942	4-Oxalocrotonate Tautomerase
D8Z23_18015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8Z23_18040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8Z23_18060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D8Z23_18065	COG1024	Enoyl-CoA hydratase
D8Z23_18070	COG1414	Transcriptional regulator
D8Z23_18075	COG0318	PFAM AMP-dependent synthetase and ligase
D8Z23_18080	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_18130	COG0330	HflC and HflK could
D8Z23_18140	COG0251	oxidation-reduction process
D8Z23_18190	COG3723	Recombinational DNA repair protein, rece pathway
D8Z23_18225	COG0582	viral genome integration into host DNA
D8Z23_18260	COG0706	membrane insertase activity
D8Z23_18265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D8Z23_18270	COG0594	ribonuclease P activity
D8Z23_18275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D8Z23_18295	COG1414	Transcriptional regulator
D8Z23_18300	COG0154	amidase activity
D8Z23_18315	COG1304	FMN binding
D8Z23_18365	COG0183	Belongs to the thiolase family
D8Z23_18370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D8Z23_18385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D8Z23_18390	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_18410	COG1629	transport
D8Z23_18415	COG2922	Belongs to the Smg family
D8Z23_18440	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8Z23_18445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_18450	COG1028	Short-chain dehydrogenase reductase Sdr
D8Z23_18455	COG1012	belongs to the aldehyde dehydrogenase family
D8Z23_18465	COG0028	Belongs to the TPP enzyme family
D8Z23_18470	COG1522	sequence-specific DNA binding
D8Z23_18475	COG3781	membrane
D8Z23_18485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D8Z23_18505	COG4206	TonB-dependent receptor
D8Z23_18510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D8Z23_18515	COG2022	thiamine diphosphate biosynthetic process
D8Z23_18520	COG0351	phosphomethylpyrimidine kinase
D8Z23_18525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D8Z23_18540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D8Z23_18550	COG0628	permease
D8Z23_18560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D8Z23_18575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D8Z23_18580	COG0049	tRNA binding
D8Z23_18585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D8Z23_18590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D8Z23_18595	COG0051	transcription antitermination factor activity, RNA binding
D8Z23_18600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D8Z23_18605	COG0088	Forms part of the polypeptide exit tunnel
D8Z23_18610	COG0089	rRNA binding
D8Z23_18615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D8Z23_18620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D8Z23_18625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D8Z23_18630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D8Z23_18635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D8Z23_18640	COG0255	Belongs to the universal ribosomal protein uL29 family
D8Z23_18645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D8Z23_18665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D8Z23_18670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D8Z23_18675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D8Z23_18680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D8Z23_18685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D8Z23_18690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D8Z23_18695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D8Z23_18700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D8Z23_18705	COG1841	ribosomal large subunit assembly
D8Z23_18710	COG0200	Binds to the 23S rRNA
D8Z23_18715	COG0201	protein transport
D8Z23_18720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D8Z23_18725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D8Z23_18730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D8Z23_18735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D8Z23_18740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D8Z23_18745	COG0202	RNA polymerase activity
D8Z23_18750	COG0203	ribosomal protein L17
D8Z23_18755	COG0537	adenosine 5'-monophosphoramidase activity
D8Z23_18760	COG1324	tolerance protein
D8Z23_18765	COG4232	protein-disulfide reductase activity
D8Z23_18780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D8Z23_18790	COG1333	cytochrome c biogenesis protein
D8Z23_18795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D8Z23_18810	COG1965	Belongs to the frataxin family
D8Z23_18825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D8Z23_18830	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D8Z23_18845	COG2814	Major facilitator Superfamily
D8Z23_18850	COG0629	single-stranded DNA binding
D8Z23_18900	COG0438	transferase activity, transferring glycosyl groups
D8Z23_18920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_18945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D8Z23_18970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8Z23_18975	COG1956	GAF domain-containing protein
D8Z23_18980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8Z23_18995	COG1652	LysM domain
D8Z23_19010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D8Z23_19025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8Z23_19055	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_19070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_19085	COG1024	Enoyl-CoA hydratase
D8Z23_19100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_19105	COG1309	transcriptional regulator
D8Z23_19110	COG2816	NAD+ diphosphatase activity
D8Z23_19115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8Z23_19155	COG0559	Belongs to the binding-protein-dependent transport system permease family
D8Z23_19200	COG2814	Major facilitator Superfamily
D8Z23_19205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D8Z23_19225	COG1999	signal sequence binding
D8Z23_19230	COG0109	protoheme IX farnesyltransferase activity
D8Z23_19270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D8Z23_19290	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D8Z23_19295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D8Z23_19305	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D8Z23_19310	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D8Z23_19320	COG0067	glutamate synthase
D8Z23_19320	COG0070	glutamate synthase
D8Z23_19320	COG0069	glutamate synthase activity
D8Z23_19330	COG3047	cAMP biosynthetic process
D8Z23_19340	COG1127	ABC transporter
D8Z23_19345	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D8Z23_19350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D8Z23_19355	COG2853	Lipoprotein
D8Z23_19370	COG0842	Transport permease protein
D8Z23_19380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D8Z23_19385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D8Z23_19390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D8Z23_19395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D8Z23_19400	COG0131	Imidazoleglycerol-phosphate dehydratase
D8Z23_19405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D8Z23_19410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D8Z23_19415	COG0107	imidazoleglycerol-phosphate synthase activity
D8Z23_19420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D8Z23_19430	COG0537	adenosine 5'-monophosphoramidase activity
D8Z23_19435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D8Z23_19440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D8Z23_19455	COG3181	Tripartite tricarboxylate transporter family receptor
D8Z23_19495	COG3451	type IV secretory pathway VirB4
D8Z23_19515	COG3504	Conjugal transfer protein
D8Z23_19520	COG2948	multi-organism process
D8Z23_19535	COG0697	spore germination
D8Z23_19555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D8Z23_19560	COG0747	negative chemotaxis
D8Z23_19570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8Z23_19585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D8Z23_19595	COG0494	nUDIX hydrolase
D8Z23_19620	COG1538	Outer membrane efflux protein
D8Z23_19640	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D8Z23_19645	COG0237	dephospho-CoA kinase activity
D8Z23_19650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D8Z23_19665	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D8Z23_19670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D8Z23_19680	COG0477	Major facilitator Superfamily
D8Z23_19685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D8Z23_19700	COG1126	abc transporter atp-binding protein
D8Z23_19705	COG0765	amino acid transport
D8Z23_19710	COG4597	amino acid ABC transporter
D8Z23_19715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D8Z23_19720	COG2884	Cell division ATP-binding protein ftsE
D8Z23_19725	COG2177	Part of the ABC transporter FtsEX involved in
D8Z23_19730	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D8Z23_19740	COG1194	a g-specific adenine glycosylase
D8Z23_19750	COG2226	methyltransferase
D8Z23_19760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_19765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_19780	COG1024	Enoyl-CoA hydratase
D8Z23_19800	COG1024	Enoyl-CoA hydratase
D8Z23_19805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D8Z23_19820	COG0753	catalase activity
D8Z23_19825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8Z23_19830	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D8Z23_19840	COG2175	clavaminate synthase activity
D8Z23_19845	COG1473	amidohydrolase
D8Z23_19850	COG4608	Belongs to the ABC transporter superfamily
D8Z23_19855	COG0444	Belongs to the ABC transporter superfamily
D8Z23_19865	COG0601	transmembrane transport
D8Z23_19870	COG0747	negative chemotaxis
D8Z23_19875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D8Z23_19890	COG5002	protein histidine kinase activity
D8Z23_19890	COG3850	Histidine kinase
D8Z23_19910	COG0436	Aminotransferase