locus-tag	class	description
BT0008	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BT0010	COG0736	holo-[acyl-carrier-protein] synthase activity
BT0012	COG0101	tRNA pseudouridine synthase activity
BT0015	COG0572	uridine kinase
BT0017	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BT0021	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BT0023	COG0632	four-way junction helicase activity
BT0023A	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BT0025	COG0217	transcriptional regulatory protein
BT0026	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BT0031	COG0681	Belongs to the peptidase S26 family
BT0053	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BT0056	COG0126	phosphoglycerate kinase activity
BT0060	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BT0064	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BT0068	COG0561	phosphatase activity
BT0069	COG2309	aminopeptidase activity
BT0076	COG0552	protein localization to endoplasmic reticulum
BT0078	COG4591	ABC-type transport system involved in lipoprotein release permease component
BT0080	COG1136	(ABC) transporter
BT0086	COG0606	chelatase, subunit chli
BT0087	COG0039	L-malate dehydrogenase activity
BT0088	COG0481	GTPase activity
BT0093	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
BT0094	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
BT0096	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
BT0099	COG1162	GTPase activity
BT0104	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BT0108	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BT0111	COG0305	Participates in initiation and elongation during chromosome replication
BT0112	COG0359	binds to the 23S rRNA
BT0113	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BT0115	COG0360	Binds together with S18 to 16S ribosomal RNA
BT0116	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BT0116	COG2190	(PTS) system
BT0116	COG1263	PTS System
BT0119	COG4589	Belongs to the CDS family
BT0121	COG0233	cytoplasmic translational termination
BT0122	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BT0123	COG0052	Belongs to the universal ribosomal protein uS2 family
BT0127	COG0539	negative regulation of cytoplasmic translation
BT0128	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BT0131	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BT0137	COG1022	Amp-dependent synthetase and ligase
BT0145	COG4176	ABC-type proline glycine betaine transport system permease component
BT0151	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BT0164	COG0530	calcium, potassium:sodium antiporter activity
BT0169	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BT0176	COG0714	Associated with various cellular activities
BT0177	COG0357	Ribosomal RNA small subunit methyltransferase G
BT0179	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BT0183	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BT0184	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BT0185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BT0188	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BT0189	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BT0190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BT0194	COG0084	hydrolase, TatD family'
BT0196	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BT0200	COG1181	Belongs to the D-alanine--D-alanine ligase family
BT0201	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BT0202	COG4536	flavin adenine dinucleotide binding
BT0206	COG0742	ribosomal rna small subunit methyltransferase
BT0211	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BT0214	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BT0216	COG0573	inorganic phosphate transmembrane transporter activity
BT0217	COG0581	inorganic phosphate transmembrane transporter activity
BT0218	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BT0225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BT0226	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BT0233	COG0268	Binds directly to 16S ribosomal RNA
BT0235	COG0012	GTP binding
BT0239	COG1428	Deoxynucleoside kinase
BT0240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BT0241A	COG2271	Major facilitator Superfamily
BT0241B	COG0584	glycerophosphoryl diester phosphodiesterase
BT0243	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BT0246	COG0739	heme binding
BT0247	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BT0251	COG0495	leucyl-tRNA aminoacylation
BT0253	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BT0254	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BT0255	COG0739	heme binding
BT0256	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BT0262	COG0739	heme binding
BT0262	COG0741	lytic transglycosylase activity
BT0262	COG1196	nuclear chromosome segregation
BT0264	COG0443	Heat shock 70 kDa protein
BT0269	COG0455	bacterial-type flagellum organization
BT0280	COG1360	Flagellar Motor Protein
BT0284	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BT0294	COG1815	bacterial-type flagellum-dependent cell motility
BT0296	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BT0303	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BT0306	COG0275	rRNA processing
BT0309A	COG0497	DNA recombination
BT0312	COG0835	chemotaxis
BT0313	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BT0329	COG4166	transmembrane transport
BT0332	COG0601	transmembrane transport
BT0333	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BT0334	COG0444	Belongs to the ABC transporter superfamily
BT0335	COG4608	Belongs to the ABC transporter superfamily
BT0338	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BT0339	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BT0341	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BT0342	COG0154	amidase activity
BT0344	COG0210	DNA helicase
BT0346	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BT0350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BT0359	COG0793	Belongs to the peptidase S41A family
BT0361	COG0455	bacterial-type flagellum organization
BT0362	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BT0366	COG1362	aminopeptidase activity
BT0368	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BT0369	COG0542	response to heat
BT0370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BT0375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BT0377	COG1854	S-ribosylhomocysteine lyase activity
BT0380	COG2239	Acts as a magnesium transporter
BT0386	COG0049	tRNA binding
BT0387	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BT0388	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BT0389	COG0085	RNA polymerase activity
BT0390	COG0222	ribosome binding
BT0391	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BT0392	COG0081	regulation of translation
BT0393	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BT0408	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BT0408	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BT0408	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BT0413A	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BT0417	COG0563	adenylate kinase activity
BT0421	COG0561	phosphatase activity
BT0421B	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BT0421C	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BT0422	COG2094	Belongs to the DNA glycosylase MPG family
BT0422A	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BT0427	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BT0431	COG1192	Involved in chromosome partitioning
BT0436	COG0187	DNA topoisomerase II activity
BT0437	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BT0438A	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BT0440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BT0441	COG0594	ribonuclease P activity
BT0442	COG0706	membrane insertase activity
BT0446	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BT0447	COG0475	glutathione-regulated potassium exporter activity
BT0451	COG2059	Chromate
BT0453	COG0668	transmembrane transport
BT0457	COG0322	excinuclease ABC activity
BT0461	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BT0462	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BT0462A	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BT0466	COG1137	ATPase activity
BT0469	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BT0473	COG0534	Mate efflux family protein
BT0476	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BT0477	COG0051	transcription antitermination factor activity, RNA binding
BT0478	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BT0479	COG0088	Forms part of the polypeptide exit tunnel
BT0480	COG0089	rRNA binding
BT0481	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BT0483	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BT0484	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BT0485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BT0486	COG0255	Belongs to the universal ribosomal protein uL29 family
BT0487	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BT0488	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BT0489	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BT0490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BT0492	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BT0493	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BT0494	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BT0500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BT0501	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BT0502	COG0202	RNA polymerase activity
BT0503	COG0203	ribosomal protein L17
BT0505	COG1692	metallophosphoesterase
BT0506	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BT0508	COG1160	GTP binding
BT0514	COG0072	phenylalanine-tRNA ligase activity
BT0522	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BT0522	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BT0522A	COG2208	phosphoserine phosphatase activity
BT0533	COG0321	lipoyl(octanoyl) transferase activity
BT0533	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BT0534	COG0708	Exodeoxyribonuclease III
BT0536	COG0612	Peptidase, M16
BT0545	COG1070	Carbohydrate kinase
BT0551	COG2201	protein-glutamate methylesterase activity
BT0552	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BT0561	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BT0565	COG0835	chemotaxis
BT0567	COG0643	Histidine kinase
BT0567	COG2198	Histidine kinase
BT0570	COG0784	Response regulator, receiver
BT0570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BT0570	COG2205	protein histidine kinase activity
BT0570	COG2198	Histidine kinase
BT0570A	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BT0571	COG0528	UMP kinase activity
BT0572	COG1216	Glycosyl transferase, family 2
BT0573	COG4555	ABC transporter
BT0575	COG0504	CTP synthase activity
BT0578	COG0840	transmembrane signaling receptor activity
BT0578	COG3290	protein histidine kinase activity
BT0583	COG0534	Mate efflux family protein
BT0586	COG2348	transferase activity, transferring amino-acyl groups
BT0587	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BT0587	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BT0590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BT0593	COG1022	Amp-dependent synthetase and ligase
BT0594	COG0018	arginyl-trna synthetase
BT0596	COG0840	transmembrane signaling receptor activity
BT0597	COG0840	transmembrane signaling receptor activity
BT0597	COG5278	phosphoserine phosphatase activity
BT0599	COG0215	cysteine-tRNA ligase activity
BT0601	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BT0602	COG0484	heat shock protein binding
BT0604	COG1620	l-lactate permease
BT0605	COG1686	Belongs to the peptidase S11 family
BT0606	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BT0608	COG2195	Cleaves the N-terminal amino acid of tripeptides
BT0610	COG0544	peptidyl-prolyl cis-trans isomerase activity
BT0611	COG0740	serine-type endopeptidase activity
BT0612	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BT0615	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BT0621	COG0693	protein deglycase activity
BT0622	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BT0625	COG1388	LysM domain
BT0625	COG1705	Flagellar rod assembly protein muramidase FlgJ
BT0629	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BT0629	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BT0629	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BT0632	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BT0634	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BT0635	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BT0638	COG1757	Na H antiporter
BT0640	COG1177	transmembrane transport
BT0641	COG1176	ABC-type spermidine putrescine transport system, permease component I
BT0644	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BT0645	COG2190	(PTS) system
BT0645	COG1263	PTS System
BT0645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BT0649	COG0459	protein refolding
BT0655	COG0484	heat shock protein binding
BT0656	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BT0658	COG0588	phosphoglycerate mutase activity
BT0660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BT0670	COG0835	chemotaxis
BT0672	COG2201	protein-glutamate methylesterase activity
BT0676	COG0546	phosphoglycolate phosphatase activity
BT0680	COG0840	transmembrane signaling receptor activity
BT0681	COG0840	transmembrane signaling receptor activity
BT0682	COG0482	sulfurtransferase activity
BT0683	COG3425	synthase
BT0684	COG1304	FMN binding
BT0691	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BT0694	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BT0695	COG0228	four-way junction DNA binding
BT0698	COG0336	Belongs to the RNA methyltransferase TrmD family
BT0699	COG0335	large ribosomal subunit rRNA binding
BT0702	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BT0703	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BT0704	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BT0705	COG0571	ribonuclease III activity
BT0706	COG0617	tRNA 3'-terminal CCA addition
BT0709	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BT0715	COG1077	Cell shape determining protein MreB Mrl
BT0718	COG0768	penicillin binding
BT0719	COG0772	Belongs to the SEDS family
BT0720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BT0724	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BT0726	COG0489	protein tyrosine kinase activity
BT0728	COG0446	pyridine nucleotide-disulphide oxidoreductase
BT0731	COG1475	DNA binding
BT0734	COG0009	L-threonylcarbamoyladenylate synthase
BT0735	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BT0735A	COG1199	ATP-dependent helicase activity
BT0737	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BT0740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BT0740	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BT0741	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BT0742	COG0488	(ABC) transporter
BT0745	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BT0747	COG0601	transmembrane transport
BT0754	COG1131	(ABC) transporter
BT0755	COG1234	tRNA 3'-trailer cleavage
BT0756	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BT0761	COG0739	heme binding
BT0763	COG2204	response regulator
BT0764	COG3852	Histidine kinase
BT0765	COG0470	DNA polymerase III
BT0767	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BT0768	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
BT0769	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BT0771	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BT0771A	COG3951	Flagellar rod assembly protein muramidase FlgJ
BT0780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BT0781	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BT0782	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BT0785	COG2088	sporulation resulting in formation of a cellular spore
BT0786	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BT0787	COG0193	aminoacyl-tRNA hydrolase activity
BT0790A	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BT0793	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BT0795	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BT0797	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BT0798	COG1040	competence protein
BT0799	COG0779	Required for maturation of 30S ribosomal subunits
BT0801	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BT0804	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BT0805	COG1185	polyribonucleotide nucleotidyltransferase activity
BT0809	COG0343	queuine tRNA-ribosyltransferase activity
BT0814	COG4145	pantothenate transmembrane transporter activity
BT0817	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BT0819	COG1102	Psort location Cytoplasmic, score
BT0821	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BT0826A	COG2190	(PTS) system
BT0826A	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BT0826A	COG1263	PTS System
BT0831	COG1940	carbohydrate kinase activity
BT0831A	COG3142	Participates in the control of copper homeostasis
BT0833	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BT0835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BT0841	COG2235	arginine
BT0843	COG1288	antiporter activity
BT0843A	COG0549	Belongs to the carbamate kinase family
BT0_B06	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BT0_B09	COG2252	PERMEase
BT0_B14	COG2190	(PTS) system
BT0_B14	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BT0_B14	COG1263	PTS System
BT0_B15	COG1263	PTS System
BT0_B15	COG2190	(PTS) system
BT0_B15	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BT0_D05	COG1192	Involved in chromosome partitioning
BT0_E02	COG1192	Involved in chromosome partitioning
BT0_F06	COG1192	Involved in chromosome partitioning
BT0_P25	COG1192	Involved in chromosome partitioning
BT0_U15	COG1192	Involved in chromosome partitioning