locus-tag	class	description
I6G94_00040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6G94_00080	COG2311	Membrane
I6G94_00095	COG2376	Dihydroxyacetone kinase
I6G94_00130	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G94_00145	COG3226	Transcriptional regulator
I6G94_00160	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_00170	COG1132	(ABC) transporter
I6G94_00195	COG1802	Transcriptional regulator
I6G94_00220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G94_00225	COG1739	Uncharacterized protein family UPF0029
I6G94_00230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G94_00240	COG0028	Belongs to the TPP enzyme family
I6G94_00260	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G94_00280	COG0765	amino acid transport
I6G94_00285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G94_00290	COG0477	Major facilitator Superfamily
I6G94_00295	COG2814	Major facilitator Superfamily
I6G94_00305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G94_00310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G94_00315	COG3485	protocatechuate 3,4-dioxygenase
I6G94_00320	COG3485	protocatechuate 3,4-dioxygenase
I6G94_00330	COG2391	methyltransferase activity
I6G94_00335	COG0425	Belongs to the sulfur carrier protein TusA family
I6G94_00350	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_00355	COG2357	RelA SpoT domain protein
I6G94_00385	COG2814	Major facilitator Superfamily
I6G94_00415	COG2239	Acts as a magnesium transporter
I6G94_00420	COG0572	uridine kinase
I6G94_00455	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_00465	COG3971	2-oxopent-4-enoate hydratase activity
I6G94_00505	COG0745	RESPONSE REGULATOR receiver
I6G94_00510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6G94_00530	COG2252	PERMEase
I6G94_00550	COG0402	S-adenosylhomocysteine deaminase activity
I6G94_00555	COG3622	Belongs to the hyi family
I6G94_00560	COG2084	Dehydrogenase
I6G94_00565	COG3960	tartronate-semialdehyde synthase activity
I6G94_00570	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G94_00580	COG1929	Belongs to the glycerate kinase type-1 family
I6G94_00590	COG2351	hydroxyisourate hydrolase activity
I6G94_00605	COG1414	Transcriptional regulator
I6G94_00625	COG0579	oxidoreductase
I6G94_00635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G94_00640	COG0277	FAD linked oxidase domain protein
I6G94_00645	COG2040	homocysteine
I6G94_00650	COG0343	queuine tRNA-ribosyltransferase activity
I6G94_00700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G94_00710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G94_00750	COG0542	response to heat
I6G94_00760	COG0706	membrane insertase activity
I6G94_00770	COG0740	serine-type endopeptidase activity
I6G94_00775	COG0740	serine-type endopeptidase activity
I6G94_00780	COG1396	sequence-specific DNA binding
I6G94_00785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G94_00820	COG0577	efflux transmembrane transporter activity
I6G94_00820	COG1136	(ABC) transporter
I6G94_00825	COG0577	efflux transmembrane transporter activity
I6G94_00835	COG0477	Major facilitator Superfamily
I6G94_00850	COG2385	sporulation resulting in formation of a cellular spore
I6G94_00855	COG0693	protein deglycase activity
I6G94_00900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G94_00915	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G94_00960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6G94_00970	COG3655	Transcriptional regulator
I6G94_00990	COG1121	(ABC) transporter
I6G94_01000	COG1408	metallophosphoesterase
I6G94_01005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G94_01025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G94_01065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G94_01110	COG3048	D-serine ammonia-lyase activity
I6G94_01135	COG1205	dead DEAH box helicase
I6G94_01135	COG1111	helicase
I6G94_01140	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G94_01145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G94_01145	COG1754	DNA topoisomerase type I activity
I6G94_01155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G94_01160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G94_01175	COG0582	viral genome integration into host DNA
I6G94_01240	COG5377	YqaJ viral recombinase family
I6G94_01260	COG0629	single-stranded DNA binding
I6G94_01305	COG0305	Participates in initiation and elongation during chromosome replication
I6G94_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G94_01575	COG0183	Belongs to the thiolase family
I6G94_01580	COG1024	Enoyl-CoA hydratase
I6G94_01580	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G94_01590	COG0604	alcohol dehydrogenase
I6G94_01595	COG1309	transcriptional regulator
I6G94_01600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G94_01610	COG1960	acyl-CoA dehydrogenase activity
I6G94_01615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G94_01660	COG2030	dehydratase
I6G94_01670	COG0242	peptide deformylase activity
I6G94_01680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G94_01690	COG0477	Major facilitator Superfamily
I6G94_01695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G94_01735	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G94_01745	COG0037	tRNA processing
I6G94_01755	COG2807	transmembrane transport
I6G94_01760	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G94_01765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G94_01770	COG0302	gtp cyclohydrolase
I6G94_01780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G94_01805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6G94_01825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G94_01835	COG1194	a g-specific adenine glycosylase
I6G94_01870	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_01880	COG0583	DNA-binding transcription factor activity
I6G94_01920	COG1122	ATPase activity
I6G94_01925	COG4721	ABC-type cobalt transport system, permease component
I6G94_01940	COG2079	MmgE PrpD family protein
I6G94_01945	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6G94_01955	COG1024	Enoyl-CoA hydratase
I6G94_01960	COG0248	Ppx GppA phosphatase
I6G94_01965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G94_01970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G94_01975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G94_01985	COG1082	Xylose isomerase domain protein TIM barrel
I6G94_01990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G94_01995	COG2197	response regulator
I6G94_02005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G94_02015	COG0569	domain protein
I6G94_02020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G94_02025	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G94_02040	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6G94_02045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6G94_02055	COG0113	porphobilinogen synthase activity
I6G94_02065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G94_02070	COG0406	alpha-ribazole phosphatase activity
I6G94_02080	COG0785	Cytochrome C biogenesis protein
I6G94_02085	COG1333	cytochrome c biogenesis protein
I6G94_02090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G94_02125	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G94_02130	COG4948	Mandelate Racemase Muconate Lactonizing
I6G94_02145	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6G94_02150	COG1169	isochorismate synthase
I6G94_02155	COG2226	methyltransferase
I6G94_02165	COG0142	geranyltranstransferase activity
I6G94_02175	COG1131	(ABC) transporter
I6G94_02195	COG2357	RelA SpoT domain protein
I6G94_02210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6G94_02220	COG1666	GTP binding
I6G94_02235	COG1473	amidohydrolase
I6G94_02245	COG0584	glycerophosphoryl diester phosphodiesterase
I6G94_02260	COG3339	Conserved Protein
I6G94_02280	COG1609	Transcriptional regulator
I6G94_02285	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_02290	COG3962	Belongs to the TPP enzyme family
I6G94_02305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G94_02315	COG0673	inositol 2-dehydrogenase activity
I6G94_02320	COG0673	inositol 2-dehydrogenase activity
I6G94_02325	COG2814	Major facilitator Superfamily
I6G94_02355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G94_02360	COG0175	sulfate reduction
I6G94_02370	COG0529	Catalyzes the synthesis of activated sulfate
I6G94_02370	COG2895	sulfate adenylyltransferase (ATP) activity
I6G94_02375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G94_02375	COG1648	precorrin-2 dehydrogenase activity
I6G94_02390	COG2197	response regulator
I6G94_02410	COG2030	dehydratase
I6G94_02420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6G94_02425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G94_02450	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6G94_02455	COG0081	regulation of translation
I6G94_02480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G94_02485	COG0222	ribosome binding
I6G94_02525	COG0085	RNA polymerase activity
I6G94_02530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6G94_02545	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
I6G94_02555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6G94_02560	COG0049	tRNA binding
I6G94_02565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G94_02570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6G94_02575	COG0366	Alpha amylase catalytic
I6G94_02600	COG0051	transcription antitermination factor activity, RNA binding
I6G94_02605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6G94_02610	COG0088	Forms part of the polypeptide exit tunnel
I6G94_02615	COG0089	rRNA binding
I6G94_02620	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6G94_02625	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6G94_02630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6G94_02635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6G94_02640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6G94_02645	COG0255	Belongs to the universal ribosomal protein uL29 family
I6G94_02650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6G94_02655	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6G94_02660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6G94_02665	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6G94_02670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6G94_02675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6G94_02680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6G94_02685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6G94_02690	COG1841	ribosomal large subunit assembly
I6G94_02695	COG0200	Binds to the 23S rRNA
I6G94_02705	COG0563	adenylate kinase activity
I6G94_02740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6G94_02745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G94_02750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6G94_02755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6G94_02760	COG0202	RNA polymerase activity
I6G94_02765	COG0203	ribosomal protein L17
I6G94_02770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G94_02795	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6G94_02800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6G94_02825	COG2076	Multidrug Resistance protein
I6G94_02840	COG1966	Carbon starvation protein
I6G94_02845	COG0180	Tryptophanyl-tRNA synthetase
I6G94_02860	COG0640	Transcriptional regulator
I6G94_02890	COG2135	peptidase activity
I6G94_02935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6G94_02945	COG1234	tRNA 3'-trailer cleavage
I6G94_02950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6G94_02955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G94_02970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G94_03035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6G94_03040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G94_03050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6G94_03055	COG0193	aminoacyl-tRNA hydrolase activity
I6G94_03070	COG3956	TIGRFAM MazG family protein
I6G94_03080	COG0148	phosphopyruvate hydratase activity
I6G94_03110	COG1252	NADH dehydrogenase
I6G94_03125	COG1733	regulation of RNA biosynthetic process
I6G94_03145	COG2326	polyphosphate kinase activity
I6G94_03155	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_03180	COG2149	membrane
I6G94_03195	COG1643	Atp-dependent helicase
I6G94_03205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6G94_03210	COG1260	myo-inositol-1-phosphate synthase
I6G94_03215	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6G94_03270	COG1228	amidohydrolase
I6G94_03275	COG0531	amino acid
I6G94_03280	COG0579	oxidoreductase
I6G94_03295	COG2828	Protein conserved in bacteria
I6G94_03315	COG1120	ATPase activity
I6G94_03335	COG0318	PFAM AMP-dependent synthetase and ligase
I6G94_03340	COG1960	acyl-CoA dehydrogenase activity
I6G94_03345	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G94_03365	COG1454	alcohol dehydrogenase
I6G94_03380	COG1349	DNA-binding transcription factor activity
I6G94_03385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G94_03390	COG3395	kinase activity
I6G94_03395	COG2610	gluconate transmembrane transporter activity
I6G94_03400	COG2217	Heavy metal translocating P-type atpase
I6G94_03420	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G94_03425	COG1879	ABC-type sugar transport system periplasmic component
I6G94_03430	COG2186	Transcriptional regulator
I6G94_03440	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G94_03460	COG2814	Major facilitator Superfamily
I6G94_03465	COG4948	Mandelate Racemase Muconate Lactonizing
I6G94_03470	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G94_03485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G94_03505	COG0477	Major facilitator Superfamily
I6G94_03510	COG2197	response regulator
I6G94_03515	COG4585	Histidine kinase
I6G94_03525	COG1414	Transcriptional regulator
I6G94_03530	COG3734	2-keto-3-deoxy-galactonokinase
I6G94_03535	COG0800	Aldolase
I6G94_03540	COG4948	Mandelate Racemase Muconate Lactonizing
I6G94_03545	COG2271	Major facilitator Superfamily
I6G94_03560	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G94_03560	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G94_03565	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G94_03590	COG3173	Aminoglycoside phosphotransferase
I6G94_03625	COG0657	acetylesterase activity
I6G94_03650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G94_03660	COG1228	amidohydrolase
I6G94_03665	COG1473	amidohydrolase
I6G94_03670	COG1285	pathogenesis
I6G94_03690	COG1953	Uracil, thiamine, allantoin
I6G94_03700	COG1802	Transcriptional regulator
I6G94_03710	COG0477	Major facilitator Superfamily
I6G94_03730	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G94_03745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G94_03755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G94_03755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G94_03790	COG1316	TRANSCRIPTIONal
I6G94_03820	COG0778	Nitroreductase
I6G94_03820	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I6G94_03850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G94_03875	COG0714	Associated with various cellular activities
I6G94_03895	COG0745	RESPONSE REGULATOR receiver
I6G94_03900	COG5002	protein histidine kinase activity
I6G94_03900	COG5000	phosphorelay sensor kinase activity
I6G94_03905	COG5401	PFAM Sporulation and spore germination
I6G94_03915	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G94_03925	COG2197	response regulator
I6G94_03940	COG3214	Protein conserved in bacteria
I6G94_03945	COG0653	protein targeting
I6G94_03990	COG2902	Dehydrogenase
I6G94_04020	COG4941	Belongs to the sigma-70 factor family
I6G94_04025	COG4770	biotin carboxylase activity
I6G94_04030	COG0424	maF-like protein
I6G94_04045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G94_04055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G94_04070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G94_04075	COG2226	methyltransferase
I6G94_04080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G94_04085	COG0114	fumarate hydratase activity
I6G94_04105	COG1722	exodeoxyribonuclease VII activity
I6G94_04110	COG1570	exodeoxyribonuclease VII activity
I6G94_04115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G94_04120	COG1322	Protein conserved in bacteria
I6G94_04140	COG1061	Type III restriction enzyme res subunit
I6G94_04160	COG0789	Transcriptional regulator
I6G94_04195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G94_04215	COG0464	growth
I6G94_04330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G94_04335	COG3158	transport of potassium into the cell
I6G94_04390	COG3845	ABC transporter
I6G94_04415	COG1435	thymidine kinase activity
I6G94_04435	COG2022	thiamine diphosphate biosynthetic process
I6G94_04445	COG2022	thiamine diphosphate biosynthetic process
I6G94_04445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G94_04450	COG0352	thiamine-phosphate diphosphorylase activity
I6G94_04455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G94_04460	COG2226	methyltransferase
I6G94_04465	COG0833	amino acid
I6G94_04475	COG0494	nUDIX hydrolase
I6G94_04485	COG0596	Alpha beta hydrolase
I6G94_04500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G94_04505	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G94_04510	COG1120	ATPase activity
I6G94_04515	COG2354	Protein conserved in bacteria
I6G94_04575	COG2318	DinB family
I6G94_04585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G94_04590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G94_04600	COG0492	ferredoxin-NADP+ reductase activity
I6G94_04640	COG3012	SEC-C Motif Domain Protein
I6G94_04650	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G94_04670	COG0681	Belongs to the peptidase S26 family
I6G94_04690	COG2197	response regulator
I6G94_04700	COG1803	Methylglyoxal synthase
I6G94_04700	COG1597	lipid kinase activity
I6G94_04705	COG0433	COG0433 Predicted ATPase
I6G94_04710	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6G94_04720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G94_04730	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G94_04735	COG5416	Lipopolysaccharide assembly protein A domain
I6G94_04740	COG2838	Isocitrate dehydrogenase
I6G94_04750	COG0596	Alpha beta hydrolase
I6G94_04755	COG0471	metal ion transport
I6G94_04760	COG1902	pentaerythritol trinitrate reductase activity
I6G94_04785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G94_04790	COG4172	Belongs to the ABC transporter superfamily
I6G94_04795	COG1217	gtp-binding protein TYPA
I6G94_04800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G94_04805	COG2720	vancomycin resistance protein
I6G94_04840	COG2171	N-acyltransferase activity
I6G94_04850	COG1611	Belongs to the LOG family
I6G94_04855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G94_04875	COG4122	O-methyltransferase activity
I6G94_04885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G94_04905	COG2239	Acts as a magnesium transporter
I6G94_04910	COG3191	aminopeptidase activity
I6G94_04915	COG0006	proline dipeptidase activity
I6G94_04990	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6G94_04995	COG1615	UPF0182 protein
I6G94_05000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G94_05050	COG1295	ribonuclease BN
I6G94_05060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G94_05145	COG4974	Belongs to the 'phage' integrase family
I6G94_05180	COG2353	YceI-like domain
I6G94_05190	COG0483	inositol monophosphate 1-phosphatase activity
I6G94_05200	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G94_05210	COG1595	DNA-templated transcription, initiation
I6G94_05225	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G94_05225	COG0567	Dehydrogenase, E1 component
I6G94_05255	COG0577	efflux transmembrane transporter activity
I6G94_05255	COG1136	(ABC) transporter
I6G94_05260	COG0577	efflux transmembrane transporter activity
I6G94_05260	COG1136	(ABC) transporter
I6G94_05265	COG2807	transmembrane transport
I6G94_05270	COG0018	arginyl-trna synthetase
I6G94_05275	COG0019	diaminopimelate decarboxylase activity
I6G94_05280	COG0460	homoserine dehydrogenase
I6G94_05285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G94_05290	COG0083	homoserine kinase activity
I6G94_05300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6G94_05315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G94_05325	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G94_05330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G94_05335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G94_05340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G94_05345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6G94_05350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G94_05355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6G94_05360	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G94_05380	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6G94_05395	COG0183	Belongs to the thiolase family
I6G94_05445	COG1946	Acyl-CoA thioesterase
I6G94_05465	COG0668	transmembrane transport
I6G94_05475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6G94_05480	COG0698	ribose 5-phosphate isomerase
I6G94_05490	COG2133	pyrroloquinoline quinone binding
I6G94_05510	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6G94_05520	COG0740	serine-type endopeptidase activity
I6G94_05525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6G94_05550	COG0525	valine-tRNA ligase activity
I6G94_05570	COG0285	dihydrofolate synthase activity
I6G94_05580	COG0105	UTP biosynthetic process
I6G94_05590	COG1530	ribonuclease E activity
I6G94_05600	COG1115	amino acid carrier protein
I6G94_05605	COG0287	Prephenate dehydrogenase
I6G94_05605	COG1605	Chorismate mutase
I6G94_05610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6G94_05615	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G94_05620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6G94_05625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6G94_05630	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6G94_05640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6G94_05650	COG0799	negative regulation of ribosome biogenesis
I6G94_05665	COG2111	Na H antiporter
I6G94_05665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G94_05670	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G94_05675	COG0651	ATP synthesis coupled electron transport
I6G94_05680	COG1863	multisubunit Na H antiporter MnhE subunit
I6G94_05705	COG2837	iron assimilation
I6G94_05755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G94_05765	COG0156	8-amino-7-oxononanoate synthase activity
I6G94_05775	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G94_05780	COG3246	L-lysine catabolic process to acetate
I6G94_05785	COG1309	transcriptional regulator
I6G94_05795	COG2364	Membrane
I6G94_05845	COG1950	PFAM Membrane protein of
I6G94_05855	COG3104	oligopeptide transport
I6G94_05860	COG0640	Transcriptional regulator
I6G94_05865	COG0477	Major facilitator Superfamily
I6G94_05925	COG0318	PFAM AMP-dependent synthetase and ligase
I6G94_05930	COG1126	abc transporter atp-binding protein
I6G94_05935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G94_05940	COG0765	amino acid transport
I6G94_05945	COG0765	amino acid transport
I6G94_05955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G94_05960	COG0297	glycogen (starch) synthase activity
I6G94_05975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G94_06005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G94_06010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G94_06020	COG2188	Transcriptional regulator
I6G94_06030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G94_06035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G94_06050	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G94_06065	COG0537	adenosine 5'-monophosphoramidase activity
I6G94_06070	COG0789	Transcriptional regulator
I6G94_06075	COG0626	cystathionine gamma-synthase activity
I6G94_06080	COG1522	sequence-specific DNA binding
I6G94_06170	COG2233	PERMEase
I6G94_06180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G94_06190	COG3022	response to hydroperoxide
I6G94_06235	COG0174	glutamine synthetase
I6G94_06240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G94_06265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6G94_06270	COG0321	lipoyl(octanoyl) transferase activity
I6G94_06280	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G94_06285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G94_06290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6G94_06295	COG0167	dihydroorotate dehydrogenase activity
I6G94_06315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I6G94_06320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G94_06325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G94_06335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G94_06340	COG0723	plastoquinol--plastocyanin reductase activity
I6G94_06345	COG2010	Cytochrome c
I6G94_06350	COG1845	cytochrome c oxidase, subunit III
I6G94_06355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G94_06375	COG0204	Acyl-transferase
I6G94_06390	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6G94_06405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G94_06410	COG2226	methyltransferase
I6G94_06430	COG0154	amidase activity
I6G94_06455	COG2271	Major facilitator Superfamily
I6G94_06470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G94_06505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G94_06535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G94_06540	COG0653	protein targeting
I6G94_06550	COG0805	protein transport
I6G94_06555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G94_06565	COG2378	regulation of single-species biofilm formation
I6G94_06590	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6G94_06595	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6G94_06605	COG4122	O-methyltransferase activity
I6G94_06615	COG1222	aaa ATPase
I6G94_06645	COG0215	cysteine-tRNA ligase activity
I6G94_06665	COG0667	Aldo Keto reductase
I6G94_06670	COG1968	undecaprenyl-diphosphatase activity
I6G94_06700	COG2030	dehydratase
I6G94_06710	COG0183	Belongs to the thiolase family
I6G94_06720	COG1960	acyl-CoA dehydrogenase activity
I6G94_06725	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G94_06730	COG2873	o-acetylhomoserine
I6G94_06735	COG0587	DNA-directed DNA polymerase activity
I6G94_06765	COG0789	Transcriptional regulator
I6G94_06770	COG2226	methyltransferase
I6G94_06775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G94_06780	COG0351	phosphomethylpyrimidine kinase
I6G94_06785	COG0254	rRNA binding
I6G94_06815	COG1119	ATPase activity
I6G94_06825	COG0560	Phosphoserine phosphatase
I6G94_06840	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_06860	COG0488	(ABC) transporter
I6G94_06865	COG0328	RNA-DNA hybrid ribonuclease activity
I6G94_06870	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G94_06875	COG0822	iron-sulfur transferase activity
I6G94_06885	COG0396	ATPase activity
I6G94_06895	COG0719	Fe-S assembly protein
I6G94_06930	COG0109	protoheme IX farnesyltransferase activity
I6G94_06940	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G94_06945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G94_06950	COG0166	Belongs to the GPI family
I6G94_06955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G94_06965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G94_06970	COG1481	regulation of sporulation
I6G94_06980	COG1660	Displays ATPase and GTPase activities
I6G94_06985	COG0322	excinuclease ABC activity
I6G94_07010	COG0556	nucleotide-excision repair
I6G94_07015	COG0237	dephospho-CoA kinase activity
I6G94_07015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G94_07025	COG0539	negative regulation of cytoplasmic translation
I6G94_07030	COG2226	methyltransferase
I6G94_07040	COG2050	protein possibly involved in aromatic compounds catabolism
I6G94_07070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G94_07080	COG0469	pyruvate kinase activity
I6G94_07090	COG0070	glutamate synthase
I6G94_07090	COG0067	glutamate synthase
I6G94_07090	COG0069	glutamate synthase activity
I6G94_07095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6G94_07100	COG0159	tryptophan synthase activity
I6G94_07105	COG0133	tryptophan synthase activity
I6G94_07110	COG0134	indole-3-glycerol-phosphate synthase activity
I6G94_07130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6G94_07135	COG0107	imidazoleglycerol-phosphate synthase activity
I6G94_07155	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6G94_07160	COG0140	phosphoribosyl-ATP diphosphatase activity
I6G94_07165	COG3201	nicotinamide mononucleotide transporter
I6G94_07170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G94_07180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G94_07190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6G94_07200	COG1758	RNA polymerase activity
I6G94_07205	COG0194	GDP metabolic process
I6G94_07210	COG0194	GDP metabolic process
I6G94_07215	COG0284	orotidine-5'-phosphate decarboxylase activity
I6G94_07220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G94_07225	COG0505	Belongs to the CarA family
I6G94_07235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G94_07240	COG0540	Belongs to the ATCase OTCase family
I6G94_07245	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6G94_07250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G94_07255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6G94_07260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6G94_07265	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G94_07270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6G94_07280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G94_07290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6G94_07295	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G94_07300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6G94_07310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6G94_07315	COG0640	Transcriptional regulator
I6G94_07320	COG0124	histidyl-tRNA synthetase
I6G94_07325	COG1234	tRNA 3'-trailer cleavage
I6G94_07330	COG1196	nuclear chromosome segregation
I6G94_07340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G94_07345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G94_07350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G94_07360	COG2255	four-way junction helicase activity
I6G94_07365	COG0632	four-way junction helicase activity
I6G94_07380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6G94_07385	COG0217	transcriptional regulatory protein
I6G94_07395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G94_07400	COG4946	Tricorn protease homolog
I6G94_07400	COG1506	peptidase
I6G94_07400	COG0823	Involved in the tonB-independent uptake of proteins
I6G94_07410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6G94_07450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G94_07460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6G94_07470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G94_07475	COG0484	heat shock protein binding
I6G94_07480	COG1420	regulation of RNA biosynthetic process
I6G94_07505	COG0481	GTPase activity
I6G94_07520	COG0268	Binds directly to 16S ribosomal RNA
I6G94_07540	COG1307	EDD domain protein, DegV family
I6G94_07545	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6G94_07560	COG0495	leucyl-tRNA aminoacylation
I6G94_07565	COG1022	Amp-dependent synthetase and ligase
I6G94_07570	COG0435	Glutathione S-transferase
I6G94_07575	COG0586	Pfam SNARE associated Golgi protein
I6G94_07580	COG1295	ribonuclease BN
I6G94_07600	COG0477	Major facilitator Superfamily
I6G94_07610	COG0358	DNA primase activity
I6G94_07615	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6G94_07650	COG0006	proline dipeptidase activity
I6G94_07660	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G94_07665	COG0423	glycine-tRNA ligase activity
I6G94_07675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G94_07680	COG1381	Involved in DNA repair and RecF pathway recombination
I6G94_07685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G94_07715	COG3739	integral membrane protein
I6G94_07730	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G94_07750	COG3253	May function as heme-dependent peroxidase
I6G94_07760	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6G94_07770	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6G94_07780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6G94_07785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G94_07795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G94_07800	COG0531	amino acid
I6G94_07805	COG0569	domain protein
I6G94_07825	COG0756	dUTP diphosphatase activity
I6G94_07845	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6G94_07855	COG4988	ABC transporter
I6G94_07860	COG1294	oxidase, subunit
I6G94_07865	COG1271	oxidase subunit
I6G94_07880	COG0187	DNA topoisomerase II activity
I6G94_07885	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G94_07890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G94_07910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6G94_07915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6G94_07945	COG1799	cell septum assembly
I6G94_07950	COG1496	oxidoreductase activity
I6G94_07955	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G94_07965	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G94_07970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6G94_07980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G94_07985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G94_07990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G94_07995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G94_08000	COG0768	penicillin binding
I6G94_08010	COG0275	rRNA processing
I6G94_08015	COG2001	Belongs to the MraZ family
I6G94_08020	COG0714	Associated with various cellular activities
I6G94_08030	COG1305	Transglutaminase-like
I6G94_08045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G94_08055	COG0142	geranyltranstransferase activity
I6G94_08065	COG1388	LysM domain
I6G94_08065	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6G94_08065	COG3409	Peptidoglycan-binding domain 1 protein
I6G94_08070	COG2815	serine threonine protein kinase
I6G94_08070	COG0515	serine threonine protein kinase
I6G94_08075	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6G94_08085	COG1716	ATPase activity
I6G94_08090	COG0509	glycine decarboxylation via glycine cleavage system
I6G94_08100	COG0582	viral genome integration into host DNA
I6G94_08170	COG0738	Major facilitator superfamily
I6G94_08175	COG0477	Major facilitator Superfamily
I6G94_08205	COG0534	Mate efflux family protein
I6G94_08210	COG0183	Belongs to the thiolase family
I6G94_08220	COG0009	L-threonylcarbamoyladenylate synthase
I6G94_08225	COG0628	permease
I6G94_08230	COG1160	GTP binding
I6G94_08235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6G94_08250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G94_08270	COG0494	nUDIX hydrolase
I6G94_08275	COG0504	CTP synthase activity
I6G94_08285	COG0438	transferase activity, transferring glycosyl groups
I6G94_08310	COG0497	DNA recombination
I6G94_08315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G94_08330	COG0647	UMP catabolic process
I6G94_08345	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_08360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G94_08365	COG0583	DNA-binding transcription factor activity
I6G94_08370	COG4948	Mandelate Racemase Muconate Lactonizing
I6G94_08375	COG4829	muconolactone delta-isomerase
I6G94_08380	COG3485	protocatechuate 3,4-dioxygenase
I6G94_08395	COG2814	Major facilitator Superfamily
I6G94_08430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G94_08455	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G94_08460	COG0165	Argininosuccinate lyase
I6G94_08465	COG1438	arginine binding
I6G94_08470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G94_08475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G94_08480	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G94_08485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6G94_08490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G94_08515	COG2271	Major facilitator Superfamily
I6G94_08525	COG2271	Major facilitator Superfamily
I6G94_08555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G94_08565	COG1794	racemase activity, acting on amino acids and derivatives
I6G94_08570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G94_08585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6G94_08585	COG0072	phenylalanine-tRNA ligase activity
I6G94_08590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6G94_08595	COG0028	Belongs to the TPP enzyme family
I6G94_08605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G94_08610	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6G94_08615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6G94_08620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G94_08640	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6G94_08655	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G94_08660	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G94_08670	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G94_08675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G94_08685	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G94_08700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G94_08710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G94_08715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6G94_08725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G94_08730	COG2137	regulation of response to DNA damage stimulus
I6G94_08735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G94_08745	COG1396	sequence-specific DNA binding
I6G94_08760	COG1674	ftsk spoiiie
I6G94_08775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G94_08785	COG1620	l-lactate permease
I6G94_08790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6G94_08795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G94_08800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G94_08810	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G94_08810	COG1902	pentaerythritol trinitrate reductase activity
I6G94_08830	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6G94_08845	COG1960	acyl-CoA dehydrogenase activity
I6G94_08860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G94_08870	COG0612	Peptidase, M16
I6G94_08875	COG1185	polyribonucleotide nucleotidyltransferase activity
I6G94_08880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6G94_08890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G94_08900	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6G94_08905	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6G94_08920	COG0779	Required for maturation of 30S ribosomal subunits
I6G94_08940	COG0442	prolyl-tRNA aminoacylation
I6G94_08960	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6G94_08965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G94_08970	COG0750	zinc metalloprotease
I6G94_08975	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G94_08980	COG1960	acyl-CoA dehydrogenase activity
I6G94_08995	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6G94_09000	COG0575	Belongs to the CDS family
I6G94_09005	COG0233	cytoplasmic translational termination
I6G94_09010	COG0528	UMP kinase activity
I6G94_09015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6G94_09020	COG0052	Belongs to the universal ribosomal protein uS2 family
I6G94_09060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6G94_09070	COG0681	Belongs to the peptidase S26 family
I6G94_09075	COG0335	large ribosomal subunit rRNA binding
I6G94_09080	COG0336	Belongs to the RNA methyltransferase TrmD family
I6G94_09085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6G94_09090	COG1837	Belongs to the UPF0109 family
I6G94_09095	COG0228	four-way junction DNA binding
I6G94_09120	COG1196	nuclear chromosome segregation
I6G94_09125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G94_09135	COG0492	ferredoxin-NADP+ reductase activity
I6G94_09140	COG3118	belongs to the thioredoxin family
I6G94_09145	COG0798	PFAM Bile acid sodium symporter
I6G94_09150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G94_09155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G94_09160	COG1695	Transcriptional regulator
I6G94_09170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G94_09195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6G94_09230	COG0789	Transcriptional regulator
I6G94_09240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G94_09245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6G94_09250	COG0571	ribonuclease III activity
I6G94_09255	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6G94_09270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6G94_09295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G94_09300	COG0765	amino acid transport
I6G94_09305	COG0765	amino acid transport
I6G94_09310	COG1126	abc transporter atp-binding protein
I6G94_09320	COG0742	ribosomal rna small subunit methyltransferase
I6G94_09345	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G94_09355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6G94_09365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G94_09370	COG0066	3-isopropylmalate dehydratase activity
I6G94_09375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6G94_09380	COG1414	Transcriptional regulator
I6G94_09385	COG2017	converts alpha-aldose to the beta-anomer
I6G94_09410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G94_09455	COG3340	Belongs to the peptidase S51 family
I6G94_09465	COG1505	serine-type exopeptidase activity
I6G94_09480	COG0477	Major facilitator Superfamily
I6G94_09485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G94_09490	COG0473	3-isopropylmalate dehydrogenase activity
I6G94_09510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G94_09515	COG4552	Acetyltransferase involved in intracellular survival and related
I6G94_09520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G94_09540	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6G94_09545	COG0440	acetolactate synthase activity
I6G94_09550	COG0028	Belongs to the TPP enzyme family
I6G94_09555	COG1132	(ABC) transporter
I6G94_09560	COG1132	(ABC) transporter
I6G94_09575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G94_09580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6G94_09610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G94_09615	COG0129	dihydroxy-acid dehydratase activity
I6G94_09620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G94_09635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G94_09645	COG1045	serine acetyltransferase
I6G94_09655	COG0242	peptide deformylase activity
I6G94_09665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6G94_09670	COG0154	amidase activity
I6G94_09685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6G94_09700	COG0482	sulfurtransferase activity
I6G94_09735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6G94_09765	COG2197	response regulator
I6G94_09775	COG2066	Belongs to the glutaminase family
I6G94_09790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G94_09795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G94_09815	COG0443	Heat shock 70 kDa protein
I6G94_09820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G94_09830	COG0789	Transcriptional regulator
I6G94_09835	COG0542	response to heat
I6G94_09850	COG0492	ferredoxin-NADP+ reductase activity
I6G94_09855	COG0596	Alpha beta hydrolase
I6G94_09890	COG3547	Transposase (IS116 IS110 IS902 family)
I6G94_09895	COG2801	Transposase and inactivated derivatives
I6G94_09900	COG2963	transposase activity
I6G94_09920	COG2963	transposase activity
I6G94_09925	COG2801	Transposase and inactivated derivatives
I6G94_09975	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G94_09990	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G94_09995	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G94_10000	COG4336	lyase activity
I6G94_10005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G94_10010	COG4770	biotin carboxylase activity
I6G94_10025	COG2378	regulation of single-species biofilm formation
I6G94_10085	COG1228	amidohydrolase
I6G94_10090	COG0531	amino acid
I6G94_10105	COG0589	response to stress
I6G94_10125	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G94_10150	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G94_10160	COG1473	amidohydrolase
I6G94_10160	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6G94_10170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G94_10170	COG1017	nitric oxide dioxygenase activity
I6G94_10180	COG2009	succinate dehydrogenase
I6G94_10195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G94_10225	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G94_10230	COG1780	Probably involved in ribonucleotide reductase function
I6G94_10240	COG0714	Associated with various cellular activities
I6G94_10270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G94_10320	COG0028	Belongs to the TPP enzyme family
I6G94_10330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6G94_10345	COG2884	Cell division ATP-binding protein ftsE
I6G94_10350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G94_10485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G94_10490	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G94_10505	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6G94_10510	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6G94_10515	COG3845	ABC transporter
I6G94_10520	COG1744	ABC transporter substrate-binding protein PnrA-like
I6G94_10535	COG0488	(ABC) transporter
I6G94_10550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G94_10565	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G94_10600	COG1846	Transcriptional regulator
I6G94_10610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G94_10620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G94_10625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G94_10645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G94_10645	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G94_10675	COG2813	Specifically methylates the guanine in position
I6G94_10680	COG1937	Protein conserved in bacteria
I6G94_10685	COG4977	sequence-specific DNA binding
I6G94_10685	COG1917	Cupin 2, conserved barrel domain protein
I6G94_10725	COG1196	nuclear chromosome segregation
I6G94_10725	COG0741	lytic transglycosylase activity
I6G94_10725	COG0739	heme binding
I6G94_10730	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6G94_10750	COG0789	Transcriptional regulator
I6G94_10770	COG1937	Protein conserved in bacteria
I6G94_10780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G94_10820	COG0798	PFAM Bile acid sodium symporter
I6G94_10825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G94_10915	COG0646	methionine synthase
I6G94_10915	COG1410	methionine synthase
I6G94_10925	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G94_10930	COG3265	gluconokinase activity
I6G94_10935	COG2610	gluconate transmembrane transporter activity
I6G94_10945	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6G94_10950	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G94_10965	COG2205	protein histidine kinase activity
I6G94_10970	COG0745	RESPONSE REGULATOR receiver
I6G94_10985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6G94_10995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6G94_11005	COG0667	Aldo Keto reductase
I6G94_11015	COG0456	acetyltransferase
I6G94_11025	COG0802	atpase or kinase
I6G94_11030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G94_11040	COG1473	amidohydrolase
I6G94_11045	COG0736	holo-[acyl-carrier-protein] synthase activity
I6G94_11050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G94_11055	COG1072	(Pantothenic acid kinase))
I6G94_11060	COG1132	(ABC) transporter
I6G94_11070	COG2188	Transcriptional regulator
I6G94_11085	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G94_11090	COG3639	organic phosphonate transmembrane transporter activity
I6G94_11095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G94_11100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6G94_11105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6G94_11120	COG0737	Belongs to the 5'-nucleotidase family
I6G94_11130	COG0101	tRNA pseudouridine synthase activity
I6G94_11140	COG0438	transferase activity, transferring glycosyl groups
I6G94_11155	COG1122	ATPase activity
I6G94_11160	COG1268	BioY protein
I6G94_11165	COG0519	Catalyzes the synthesis of GMP from XMP
I6G94_11165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G94_11180	COG0516	GMP reductase activity
I6G94_11185	COG0583	DNA-binding transcription factor activity
I6G94_11195	COG0668	transmembrane transport
I6G94_11200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6G94_11205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6G94_11210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6G94_11215	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G94_11245	COG0351	phosphomethylpyrimidine kinase
I6G94_11250	COG0352	thiamine-phosphate diphosphorylase activity
I6G94_11255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6G94_11265	COG4214	carbohydrate transport
I6G94_11275	COG4213	ABC transporter substrate-binding protein
I6G94_11280	COG1609	Transcriptional regulator
I6G94_11290	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6G94_11310	COG0564	pseudouridine synthase activity
I6G94_11325	COG0459	protein refolding
I6G94_11330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G94_11335	COG3583	domain protein
I6G94_11340	COG0084	hydrolase, TatD family'
I6G94_11375	COG2089	acid synthase
I6G94_11385	COG1216	Glycosyl transferase, family 2
I6G94_11410	COG0753	catalase activity
I6G94_11425	COG2011	ABC-type metal ion transport system permease component
I6G94_11430	COG1464	Belongs to the NlpA lipoprotein family
I6G94_11435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G94_11460	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6G94_11480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G94_11485	COG0579	oxidoreductase
I6G94_11510	COG0657	acetylesterase activity
I6G94_11515	COG0513	Belongs to the DEAD box helicase family
I6G94_11525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G94_11530	COG0601	transmembrane transport
I6G94_11535	COG0747	negative chemotaxis
I6G94_11570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G94_11585	COG1442	glycosyl transferase family 8
I6G94_11585	COG1216	Glycosyl transferase, family 2
I6G94_11590	COG0598	Magnesium transport protein CorA
I6G94_11620	COG1063	alcohol dehydrogenase
I6G94_11625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G94_11630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G94_11635	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G94_11660	COG0387	Pfam Sodium calcium exchanger
I6G94_11675	COG0667	Aldo Keto reductase
I6G94_11690	COG0640	Transcriptional regulator
I6G94_11710	COG2818	Glycosylase
I6G94_11715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G94_11720	COG2031	fatty acid transporter
I6G94_11725	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_11735	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G94_11755	COG0318	PFAM AMP-dependent synthetase and ligase
I6G94_11760	COG1024	Enoyl-CoA hydratase
I6G94_11770	COG0626	cystathionine gamma-synthase activity
I6G94_11780	COG2855	membrane
I6G94_11870	COG0701	Predicted permease
I6G94_11885	COG1388	LysM domain
I6G94_11885	COG3103	Sh3 type 3 domain protein
I6G94_11885	COG0791	NLP P60 protein
I6G94_11895	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_11900	COG0259	pyridoxamine-phosphate oxidase activity
I6G94_11905	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G94_11925	COG1278	Cold shock
I6G94_11940	COG1061	Type III restriction enzyme res subunit
I6G94_11945	COG0488	(ABC) transporter
I6G94_11960	COG0745	RESPONSE REGULATOR receiver
I6G94_11965	COG2205	protein histidine kinase activity
I6G94_11970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G94_11990	COG0501	Belongs to the peptidase M48B family
I6G94_12025	COG0459	protein refolding
I6G94_12030	COG1278	Cold shock
I6G94_12045	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_12050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G94_12075	COG3483	tryptophan 2,3-dioxygenase activity
I6G94_12105	COG0515	serine threonine protein kinase
I6G94_12105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G94_12110	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6G94_12125	COG1609	Transcriptional regulator
I6G94_12130	COG3842	ATPase activity
I6G94_12140	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_12145	COG0531	amino acid
I6G94_12155	COG0215	cysteine-tRNA ligase activity
I6G94_12160	COG0733	neurotransmitter:sodium symporter activity
I6G94_12185	COG1113	amino acid transport
I6G94_12205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I6G94_12210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6G94_12225	COG0745	RESPONSE REGULATOR receiver
I6G94_12230	COG5002	protein histidine kinase activity
I6G94_12250	COG0588	phosphoglycerate mutase activity
I6G94_12255	COG0385	Bile acid
I6G94_12270	COG0297	glycogen (starch) synthase activity
I6G94_12320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G94_12330	COG0589	response to stress
I6G94_12350	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G94_12360	COG3842	ATPase activity
I6G94_12365	COG0366	Alpha amylase catalytic
I6G94_12370	COG0395	ABC-type sugar transport system, permease component
I6G94_12375	COG1175	transmembrane transport
I6G94_12380	COG1653	transport
I6G94_12405	COG2197	response regulator
I6G94_12420	COG0354	folic acid binding
I6G94_12425	COG3485	protocatechuate 3,4-dioxygenase
I6G94_12435	COG0745	RESPONSE REGULATOR receiver
I6G94_12470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G94_12495	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G94_12510	COG4948	Mandelate Racemase Muconate Lactonizing
I6G94_12515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6G94_12520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G94_12525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G94_12560	COG1024	Enoyl-CoA hydratase
I6G94_12565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G94_12570	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G94_12585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G94_12595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G94_12605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G94_12610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G94_12620	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G94_12625	COG1349	DNA-binding transcription factor activity
I6G94_12650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G94_12655	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I6G94_12660	COG2188	Transcriptional regulator
I6G94_12675	COG2154	pterin-4-alpha-carbinolamine dehydratase
I6G94_12680	COG0667	Aldo Keto reductase
I6G94_12690	COG1132	(ABC) transporter
I6G94_12695	COG0438	transferase activity, transferring glycosyl groups
I6G94_12700	COG0438	transferase activity, transferring glycosyl groups
I6G94_12715	COG5002	protein histidine kinase activity
I6G94_12715	COG3850	Histidine kinase
I6G94_12755	COG0589	response to stress
I6G94_12755	COG0475	glutathione-regulated potassium exporter activity
I6G94_12770	COG2197	response regulator
I6G94_12775	COG4585	Histidine kinase
I6G94_12780	COG2409	Drug exporters of the RND superfamily
I6G94_12785	COG1335	isochorismatase
I6G94_12790	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6G94_12810	COG0531	amino acid
I6G94_12815	COG0137	argininosuccinate synthase activity
I6G94_12845	COG2188	Transcriptional regulator
I6G94_12865	COG3962	Belongs to the TPP enzyme family
I6G94_12880	COG1082	Xylose isomerase domain protein TIM barrel
I6G94_12885	COG2814	Major facilitator Superfamily
I6G94_12890	COG0589	response to stress
I6G94_12900	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6G94_12940	COG1316	TRANSCRIPTIONal
I6G94_12955	COG2409	Drug exporters of the RND superfamily
I6G94_12960	COG1309	transcriptional regulator
I6G94_12980	COG0531	amino acid
I6G94_13000	COG0596	Alpha beta hydrolase
I6G94_13010	COG0604	alcohol dehydrogenase
I6G94_13010	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_13010	COG3321	synthase
I6G94_13025	COG0561	phosphatase activity
I6G94_13030	COG0561	phosphatase activity
I6G94_13035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G94_13040	COG1597	lipid kinase activity
I6G94_13080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G94_13100	COG0831	urea catabolic process
I6G94_13110	COG0789	Transcriptional regulator
I6G94_13115	COG0484	heat shock protein binding
I6G94_13120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6G94_13125	COG0443	Heat shock 70 kDa protein
I6G94_13145	COG3290	protein histidine kinase activity
I6G94_13150	COG0745	RESPONSE REGULATOR receiver
I6G94_13160	COG2186	Transcriptional regulator
I6G94_13165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G94_13170	COG0746	molybdenum cofactor guanylyltransferase activity
I6G94_13190	COG0514	ATP-dependent DNA helicase (RecQ)
I6G94_13205	COG0583	DNA-binding transcription factor activity
I6G94_13220	COG1511	domain protein
I6G94_13225	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G94_13235	COG2814	Major facilitator Superfamily
I6G94_13255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G94_13255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G94_13260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6G94_13265	COG0028	Belongs to the TPP enzyme family
I6G94_13270	COG2271	Major facilitator Superfamily
I6G94_13275	COG0673	inositol 2-dehydrogenase activity
I6G94_13280	COG4608	Belongs to the ABC transporter superfamily
I6G94_13285	COG0444	Belongs to the ABC transporter superfamily
I6G94_13295	COG0601	transmembrane transport
I6G94_13300	COG1940	carbohydrate kinase activity
I6G94_13300	COG1846	Transcriptional regulator
I6G94_13305	COG4166	transmembrane transport
I6G94_13325	COG2315	Protein conserved in bacteria
I6G94_13330	COG0252	asparaginase activity
I6G94_13345	COG2130	NADP-dependent
I6G94_13380	COG2197	response regulator
I6G94_13395	COG0640	Transcriptional regulator
I6G94_13410	COG2197	response regulator
I6G94_13420	COG4585	Histidine kinase
I6G94_13430	COG4585	Histidine kinase
I6G94_13435	COG2197	response regulator
I6G94_13445	COG0431	NADPH-dependent FMN reductase
I6G94_13450	COG3226	Transcriptional regulator
I6G94_13460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G94_13465	COG0601	transmembrane transport
I6G94_13475	COG1115	amino acid carrier protein
I6G94_13480	COG0191	fructose-bisphosphate aldolase activity
I6G94_13505	COG1309	transcriptional regulator
I6G94_13510	COG1131	(ABC) transporter
I6G94_13515	COG3559	Exporter of polyketide antibiotics
I6G94_13540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G94_13545	COG1216	Glycosyl transferase, family 2
I6G94_13550	COG0438	transferase activity, transferring glycosyl groups
I6G94_13555	COG0489	protein tyrosine kinase activity
I6G94_13560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G94_13565	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G94_13575	COG1086	Polysaccharide biosynthesis protein
I6G94_13595	COG1960	acyl-CoA dehydrogenase activity
I6G94_13600	COG1960	acyl-CoA dehydrogenase activity
I6G94_13615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G94_13620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G94_13635	COG1595	DNA-templated transcription, initiation
I6G94_13640	COG1302	Protein conserved in bacteria
I6G94_13670	COG0300	oxidoreductase activity
I6G94_13695	COG1215	transferase activity, transferring glycosyl groups
I6G94_13715	COG0542	response to heat
I6G94_13735	COG2957	Belongs to the agmatine deiminase family
I6G94_13745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G94_13755	COG1024	Enoyl-CoA hydratase
I6G94_13760	COG2814	Major facilitator Superfamily
I6G94_13770	COG0069	glutamate synthase activity
I6G94_13780	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_13790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G94_13795	COG0318	PFAM AMP-dependent synthetase and ligase
I6G94_13800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G94_13875	COG0436	Aminotransferase
I6G94_13900	COG4948	Mandelate Racemase Muconate Lactonizing
I6G94_13905	COG0471	metal ion transport
I6G94_13910	COG0583	DNA-binding transcription factor activity
I6G94_13920	COG1230	cation diffusion facilitator family transporter
I6G94_13935	COG2234	aminopeptidase activity
I6G94_13960	COG0710	3-dehydroquinate dehydratase activity
I6G94_13965	COG3448	diguanylate cyclase activity
I6G94_13965	COG4175	Glycine betaine
I6G94_13980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G94_14010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G94_14015	COG1349	DNA-binding transcription factor activity
I6G94_14030	COG1940	carbohydrate kinase activity
I6G94_14035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G94_14040	COG2814	Major facilitator Superfamily
I6G94_14060	COG1320	monovalent cation:proton antiporter activity
I6G94_14075	COG0651	ATP synthesis coupled electron transport
I6G94_14080	COG1006	Multisubunit Na H antiporter MnhC subunit
I6G94_14085	COG2111	Na H antiporter
I6G94_14085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G94_14095	COG0717	Belongs to the dCTP deaminase family
I6G94_14120	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G94_14135	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_14145	COG3336	cytochrome c oxidase
I6G94_14150	COG0776	regulation of translation
I6G94_14155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6G94_14160	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6G94_14165	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6G94_14180	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G94_14185	COG0022	dehydrogenase e1 component
I6G94_14235	COG2814	Major facilitator Superfamily
I6G94_14240	COG0477	Major facilitator Superfamily
I6G94_14255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G94_14260	COG0768	penicillin binding
I6G94_14295	COG1937	Protein conserved in bacteria
I6G94_14330	COG0745	RESPONSE REGULATOR receiver
I6G94_14335	COG2205	protein histidine kinase activity
I6G94_14355	COG1073	alpha beta
I6G94_14365	COG3387	PFAM Glycoside hydrolase 15-related
I6G94_14390	COG0514	ATP-dependent DNA helicase (RecQ)
I6G94_14400	COG1522	sequence-specific DNA binding
I6G94_14430	COG2326	polyphosphate kinase activity
I6G94_14440	COG2860	membrane
I6G94_14450	COG1764	response to oxidative stress
I6G94_14465	COG1595	DNA-templated transcription, initiation
I6G94_14490	COG2197	response regulator
I6G94_14500	COG4152	abc transporter atp-binding protein
I6G94_14520	COG1131	(ABC) transporter
I6G94_14540	COG0730	response to heat
I6G94_14550	COG0583	DNA-binding transcription factor activity
I6G94_14555	COG1982	Orn Lys Arg decarboxylase major
I6G94_14560	COG0477	Major facilitator Superfamily
I6G94_14575	COG1902	pentaerythritol trinitrate reductase activity
I6G94_14575	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G94_14590	COG4638	Rieske (2fe-2S)
I6G94_14595	COG0583	DNA-binding transcription factor activity
I6G94_14650	COG0477	Major facilitator Superfamily
I6G94_14655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G94_14680	COG3386	PFAM SMP-30 Gluconolaconase
I6G94_14690	COG2364	Membrane
I6G94_14710	COG4221	oxidoreductase activity
I6G94_14725	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G94_14755	COG0437	4 iron, 4 sulfur cluster binding
I6G94_14760	COG0243	molybdopterin cofactor binding
I6G94_14760	COG3383	formate dehydrogenase (NAD+) activity
I6G94_14765	COG3383	formate dehydrogenase (NAD+) activity
I6G94_14765	COG0243	molybdopterin cofactor binding
I6G94_14775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G94_14780	COG0390	transport system, permease component
I6G94_14785	COG1278	Cold shock
I6G94_14790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G94_14795	COG1349	DNA-binding transcription factor activity
I6G94_14810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G94_14810	COG2080	2 iron, 2 sulfur cluster binding
I6G94_14825	COG1607	acyl-coa hydrolase
I6G94_14835	COG4221	oxidoreductase activity
I6G94_14845	COG1309	transcriptional regulator
I6G94_14855	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_14870	COG0305	Participates in initiation and elongation during chromosome replication
I6G94_14885	COG1136	(ABC) transporter
I6G94_14885	COG0577	efflux transmembrane transporter activity
I6G94_14895	COG0346	lactoylglutathione lyase activity
I6G94_14905	COG2733	membrane
I6G94_14925	COG2226	methyltransferase
I6G94_14935	COG0359	binds to the 23S rRNA
I6G94_14940	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G94_14950	COG0360	Binds together with S18 to 16S ribosomal RNA
I6G94_14960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G94_14965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G94_14970	COG0617	tRNA 3'-terminal CCA addition
I6G94_14995	COG0492	ferredoxin-NADP+ reductase activity
I6G94_15000	COG3118	belongs to the thioredoxin family
I6G94_15005	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G94_15005	COG3409	Peptidoglycan-binding domain 1 protein
I6G94_15015	COG1192	Involved in chromosome partitioning
I6G94_15020	COG0357	Ribosomal RNA small subunit methyltransferase G
I6G94_15035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6G94_15040	COG0594	ribonuclease P activity
I6G94_15045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6G94_15050	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G94_15055	COG0592	DNA-directed DNA polymerase activity
I6G94_15060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G94_15065	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
I6G94_15070	COG0187	DNA topoisomerase II activity
I6G94_15075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G94_15095	COG2132	Multicopper oxidase
I6G94_15110	COG2814	Major facilitator Superfamily
I6G94_15115	COG2814	Major facilitator Superfamily
I6G94_15135	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_15175	COG2837	iron assimilation
I6G94_15190	COG4946	Tricorn protease homolog
I6G94_15190	COG0793	Belongs to the peptidase S41A family
I6G94_15195	COG0018	arginyl-trna synthetase
I6G94_15200	COG2807	transmembrane transport
I6G94_15205	COG0277	FAD linked oxidase domain protein
I6G94_15215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G94_15230	COG3764	Sortase (surface protein transpeptidase)
I6G94_15250	COG0515	serine threonine protein kinase
I6G94_15255	COG0515	serine threonine protein kinase
I6G94_15260	COG0768	penicillin binding
I6G94_15320	COG1064	alcohol dehydrogenase
I6G94_15355	COG0384	phenazine biosynthesis protein PhzF
I6G94_15365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G94_15375	COG2233	PERMEase
I6G94_15385	COG2186	Transcriptional regulator
I6G94_15390	COG0531	amino acid
I6G94_15400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G94_15405	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_15420	COG1115	amino acid carrier protein
I6G94_15455	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I6G94_15465	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_15475	COG0318	PFAM AMP-dependent synthetase and ligase
I6G94_15480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G94_15485	COG1960	acyl-CoA dehydrogenase activity
I6G94_15495	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G94_15500	COG0022	dehydrogenase e1 component
I6G94_15520	COG1522	sequence-specific DNA binding
I6G94_15530	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G94_15545	COG1309	transcriptional regulator
I6G94_15595	COG1414	Transcriptional regulator
I6G94_15605	COG1119	ATPase activity
I6G94_15635	COG0477	Major facilitator Superfamily
I6G94_15645	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_15645	COG2030	dehydratase
I6G94_15655	COG1309	transcriptional regulator
I6G94_15665	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I6G94_15665	COG2050	protein possibly involved in aromatic compounds catabolism
I6G94_15670	COG1215	transferase activity, transferring glycosyl groups
I6G94_15675	COG0438	transferase activity, transferring glycosyl groups
I6G94_15680	COG3396	Phenylacetate-CoA oxygenase
I6G94_15685	COG3460	Phenylacetate-CoA oxygenase
I6G94_15690	COG3396	Phenylacetate-CoA oxygenase
I6G94_15695	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G94_15700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G94_15710	COG1024	Enoyl-CoA hydratase
I6G94_15715	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G94_15720	COG1024	Enoyl-CoA hydratase
I6G94_15725	COG0398	Pfam SNARE associated Golgi protein
I6G94_15760	COG1473	amidohydrolase
I6G94_15765	COG1063	alcohol dehydrogenase
I6G94_15775	COG4638	Rieske (2fe-2S)
I6G94_15790	COG3619	membrane
I6G94_15800	COG2188	Transcriptional regulator
I6G94_15825	COG0531	amino acid
I6G94_15845	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_15850	COG3246	L-lysine catabolic process to acetate
I6G94_15860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G94_15870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G94_15875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G94_15910	COG1063	alcohol dehydrogenase
I6G94_15925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6G94_15930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G94_15965	COG1802	Transcriptional regulator
I6G94_15970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G94_15975	COG1024	Enoyl-CoA hydratase
I6G94_15980	COG2084	Dehydrogenase
I6G94_15985	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_16000	COG0149	triose-phosphate isomerase activity
I6G94_16005	COG0698	ribose 5-phosphate isomerase
I6G94_16010	COG2376	Dihydroxyacetone kinase
I6G94_16025	COG1846	Transcriptional regulator
I6G94_16030	COG2066	Belongs to the glutaminase family
I6G94_16095	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G94_16100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G94_16105	COG1012	belongs to the aldehyde dehydrogenase family
I6G94_16135	COG2072	flavoprotein involved in K transport
I6G94_16140	COG1027	Aspartate ammonia-lyase
I6G94_16150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G94_16155	COG2197	response regulator
I6G94_16160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G94_16180	COG2261	transglycosylase associated protein
I6G94_16190	COG0436	Aminotransferase
I6G94_16205	COG1309	transcriptional regulator
I6G94_16225	COG0436	Aminotransferase
I6G94_16230	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6G94_16235	COG0154	amidase activity
I6G94_16250	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G94_16255	COG1228	amidohydrolase
I6G94_16260	COG3314	Sporulation integral membrane protein YlbJ
I6G94_16265	COG2986	histidine ammonia-lyase
I6G94_16270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G94_16295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G94_16305	COG0180	Tryptophanyl-tRNA synthetase
I6G94_16315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6G94_16320	COG0402	S-adenosylhomocysteine deaminase activity
I6G94_16330	COG1609	Transcriptional regulator
I6G94_16335	COG2233	PERMEase
I6G94_16340	COG0415	Belongs to the DNA photolyase family
I6G94_16395	COG1321	iron dependent repressor
I6G94_16420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G94_16435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G94_16450	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G94_16460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G94_16475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G94_16480	COG0569	domain protein
I6G94_16490	COG1131	(ABC) transporter
I6G94_16515	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6G94_16530	COG1396	sequence-specific DNA binding
I6G94_16530	COG3800	Transcriptional regulator
I6G94_16540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G94_16545	COG2318	DinB family
I6G94_16555	COG0589	response to stress
I6G94_16560	COG0247	lactate metabolic process
I6G94_16560	COG0277	FAD linked oxidase domain protein
I6G94_16605	COG1228	amidohydrolase
I6G94_16620	COG0318	PFAM AMP-dependent synthetase and ligase
I6G94_16625	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_16640	COG0477	Major facilitator Superfamily
I6G94_16645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G94_16645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6G94_16650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G94_16655	COG0509	glycine decarboxylation via glycine cleavage system
I6G94_16665	COG0456	acetyltransferase
I6G94_16670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G94_16675	COG1917	Cupin 2, conserved barrel domain protein
I6G94_16680	COG1115	amino acid carrier protein
I6G94_16690	COG0584	glycerophosphoryl diester phosphodiesterase
I6G94_16700	COG1331	Highly conserved protein containing a thioredoxin domain
I6G94_16705	COG1136	(ABC) transporter
I6G94_16770	COG2358	TRAP transporter, solute receptor (TAXI family
I6G94_16780	COG1362	aminopeptidase activity
I6G94_16790	COG3590	peptidase
I6G94_16795	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G94_16800	COG2372	response to copper ion
I6G94_16825	COG1216	Glycosyl transferase, family 2
I6G94_16830	COG2197	response regulator
I6G94_16845	COG0583	DNA-binding transcription factor activity
I6G94_16850	COG1053	succinate dehydrogenase
I6G94_16875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G94_16880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G94_16905	COG1316	TRANSCRIPTIONal
I6G94_16910	COG0537	adenosine 5'-monophosphoramidase activity
I6G94_16925	COG2814	Major facilitator Superfamily
I6G94_16935	COG1733	regulation of RNA biosynthetic process
I6G94_16940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6G94_16950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G94_16980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G94_16980	COG2022	thiamine diphosphate biosynthetic process
I6G94_16985	COG1802	Transcriptional regulator
I6G94_16990	COG3938	Belongs to the proline racemase family
I6G94_17000	COG1115	amino acid carrier protein
I6G94_17005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G94_17015	COG1134	teichoic acid transport
I6G94_17015	COG1388	LysM domain
I6G94_17020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G94_17025	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G94_17040	COG1215	transferase activity, transferring glycosyl groups
I6G94_17045	COG1086	Polysaccharide biosynthesis protein
I6G94_17060	COG0438	transferase activity, transferring glycosyl groups
I6G94_17065	COG1682	transport, permease protein
I6G94_17070	COG1134	teichoic acid transport
I6G94_17080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6G94_17090	COG0438	transferase activity, transferring glycosyl groups
I6G94_17115	COG1301	dicarboxylic acid transport
I6G94_17120	COG3290	protein histidine kinase activity
I6G94_17125	COG0745	RESPONSE REGULATOR receiver
I6G94_17130	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6G94_17150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G94_17165	COG1253	flavin adenine dinucleotide binding
I6G94_17230	COG2409	Drug exporters of the RND superfamily
I6G94_17240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G94_17245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6G94_17255	COG1028	Short-chain dehydrogenase reductase Sdr
I6G94_17265	COG0702	epimerase
I6G94_17300	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G94_17305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6G94_17310	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G94_17340	COG2017	converts alpha-aldose to the beta-anomer
I6G94_17355	COG1335	isochorismatase
I6G94_17365	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6G94_17365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G94_17375	COG1271	oxidase subunit
I6G94_17380	COG1294	oxidase, subunit
I6G94_17390	COG1132	(ABC) transporter
I6G94_17395	COG1132	(ABC) transporter
I6G94_17430	COG0477	Major facilitator Superfamily
I6G94_17470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G94_17475	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G94_17480	COG3119	arylsulfatase activity
I6G94_17515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G94_17520	COG1054	Belongs to the UPF0176 family
I6G94_17545	COG1090	epimerase
I6G94_17600	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G94_17605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G94_17610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G94_17615	COG1177	transmembrane transport
I6G94_17630	COG3842	ATPase activity
I6G94_17635	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G94_17645	COG0151	Belongs to the GarS family