locus-tag	class	description
HZY74_00065	COG0563	adenylate kinase activity
HZY74_00075	COG0200	Binds to the 23S rRNA
HZY74_00080	COG1841	ribosomal large subunit assembly
HZY74_00090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HZY74_00095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HZY74_00105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HZY74_00115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HZY74_00120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HZY74_00125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HZY74_00135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HZY74_00140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HZY74_00145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HZY74_00150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HZY74_00155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HZY74_00170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HZY74_00175	COG0051	transcription antitermination factor activity, RNA binding
HZY74_00200	COG1376	ErfK ybiS ycfS ynhG family protein
HZY74_00220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZY74_00225	COG0861	Integral membrane protein TerC family
HZY74_00230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZY74_00240	COG0534	Mate efflux family protein
HZY74_00255	COG4770	biotin carboxylase activity
HZY74_00275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HZY74_00290	COG0513	Belongs to the DEAD box helicase family
HZY74_00310	COG0316	Belongs to the HesB IscA family
HZY74_00315	COG2151	metal-sulfur cluster biosynthetic enzyme
HZY74_00320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HZY74_00325	COG0719	Fe-S assembly protein
HZY74_00340	COG0719	Fe-S assembly protein
HZY74_00345	COG2945	thiolester hydrolase activity
HZY74_00370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HZY74_00375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HZY74_00385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZY74_00430	COG0352	thiamine-phosphate diphosphorylase activity
HZY74_00440	COG0640	Transcriptional regulator
HZY74_00455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HZY74_00465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZY74_00480	COG2818	Glycosylase
HZY74_00505	COG0469	pyruvate kinase activity
HZY74_00550	COG4786	Flagellar basal body rod
HZY74_00555	COG4786	Flagellar basal body rod
HZY74_00565	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HZY74_00590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZY74_00600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZY74_00615	COG0784	Response regulator, receiver
HZY74_00630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZY74_00640	COG2204	response regulator
HZY74_00645	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZY74_00655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HZY74_00660	COG1766	The M ring may be actively involved in energy transduction
HZY74_00675	COG1233	COG1233 Phytoene dehydrogenase and related
HZY74_00695	COG2308	Evidence 4 Homologs of previously reported genes of
HZY74_00720	COG0477	Major facilitator Superfamily
HZY74_00725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HZY74_00730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZY74_00735	COG1845	cytochrome c oxidase, subunit III
HZY74_00760	COG0366	Alpha amylase catalytic
HZY74_00785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HZY74_00790	COG0483	inositol monophosphate 1-phosphatase activity
HZY74_00820	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HZY74_00845	COG2089	acid synthase
HZY74_00865	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HZY74_00875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HZY74_00900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HZY74_00905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HZY74_00915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZY74_00925	COG3273	potassium ion transport
HZY74_00925	COG0471	metal ion transport
HZY74_00950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZY74_00950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HZY74_00985	COG1132	(ABC) transporter
HZY74_00995	COG1519	Transferase
HZY74_01010	COG1073	alpha beta
HZY74_01080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HZY74_01095	COG0629	single-stranded DNA binding
HZY74_01110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZY74_01125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZY74_01135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HZY74_01175	COG0617	tRNA 3'-terminal CCA addition
HZY74_01230	COG2226	methyltransferase
HZY74_01245	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZY74_01265	COG0193	aminoacyl-tRNA hydrolase activity
HZY74_01285	COG0626	cystathionine gamma-synthase activity
HZY74_01290	COG0460	homoserine dehydrogenase
HZY74_01295	COG0012	GTP binding
HZY74_01325	COG2857	Cytochrome c1
HZY74_01325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HZY74_01335	COG0723	plastoquinol--plastocyanin reductase activity
HZY74_01340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HZY74_01350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZY74_01355	COG0408	coproporphyrinogen oxidase activity
HZY74_01360	COG0784	Response regulator, receiver
HZY74_01360	COG2205	protein histidine kinase activity
HZY74_01360	COG2198	Histidine kinase
HZY74_01365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HZY74_01370	COG1063	alcohol dehydrogenase
HZY74_01435	COG1462	curli production assembly transport component CsgG
HZY74_01445	COG0612	Peptidase, M16
HZY74_01470	COG1702	phosphate starvation-inducible protein PhoH
HZY74_01475	COG0751	glycine-tRNA ligase activity
HZY74_01480	COG2852	Protein conserved in bacteria
HZY74_01515	COG1573	uracil-dna glycosylase
HZY74_01520	COG1196	nuclear chromosome segregation
HZY74_01520	COG0739	heme binding
HZY74_01520	COG0741	lytic transglycosylase activity
HZY74_01585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HZY74_01600	COG2205	protein histidine kinase activity
HZY74_01610	COG0745	RESPONSE REGULATOR receiver
HZY74_01665	COG1692	metallophosphoesterase
HZY74_01680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HZY74_01695	COG0047	phosphoribosylformylglycinamidine synthase activity
HZY74_01705	COG1881	PFAM PEBP family protein
HZY74_01710	COG2003	Belongs to the UPF0758 family
HZY74_01720	COG0024	Methionine aminopeptidase
HZY74_01725	COG1489	DNA binding
HZY74_01730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HZY74_01760	COG2166	iron-sulfur cluster assembly
HZY74_01765	COG2205	protein histidine kinase activity
HZY74_01790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HZY74_01820	COG1218	3'(2'),5'-bisphosphate nucleotidase
HZY74_01830	COG0745	RESPONSE REGULATOR receiver
HZY74_01870	COG0784	Response regulator, receiver
HZY74_01870	COG2205	protein histidine kinase activity
HZY74_01870	COG2198	Histidine kinase
HZY74_01875	COG1024	Enoyl-CoA hydratase
HZY74_01880	COG3588	fructose-bisphosphate aldolase
HZY74_01905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HZY74_01910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HZY74_01915	COG0484	heat shock protein binding
HZY74_01940	COG3152	Membrane
HZY74_01945	COG3152	Membrane
HZY74_02010	COG4695	Portal protein
HZY74_02015	COG2204	response regulator
HZY74_02020	COG2205	protein histidine kinase activity
HZY74_02020	COG0784	Response regulator, receiver
HZY74_02050	COG0443	Heat shock 70 kDa protein
HZY74_02055	COG2214	Heat shock protein DnaJ domain protein
HZY74_02080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HZY74_02090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HZY74_02105	COG0730	response to heat
HZY74_02115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HZY74_02130	COG1012	belongs to the aldehyde dehydrogenase family
HZY74_02140	COG2205	protein histidine kinase activity
HZY74_02140	COG2202	Pas domain
HZY74_02155	COG1595	DNA-templated transcription, initiation
HZY74_02165	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HZY74_02180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZY74_02190	COG1138	Cytochrome C-type biogenesis protein
HZY74_02195	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HZY74_02210	COG2205	protein histidine kinase activity
HZY74_02215	COG0745	RESPONSE REGULATOR receiver
HZY74_02230	COG0384	phenazine biosynthesis protein PhzF
HZY74_02245	COG0446	pyridine nucleotide-disulphide oxidoreductase
HZY74_02245	COG1902	pentaerythritol trinitrate reductase activity
HZY74_02250	COG0351	phosphomethylpyrimidine kinase
HZY74_02270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HZY74_02295	COG0037	tRNA processing
HZY74_02310	COG2885	chlorophyll binding
HZY74_02340	COG0824	Thioesterase
HZY74_02360	COG1960	acyl-CoA dehydrogenase activity
HZY74_02370	COG1960	acyl-CoA dehydrogenase activity
HZY74_02375	COG5001	Diguanylate cyclase
HZY74_02405	COG2255	four-way junction helicase activity
HZY74_02420	COG2271	Major facilitator Superfamily
HZY74_02425	COG1285	pathogenesis
HZY74_02490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZY74_02570	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HZY74_02610	COG0538	isocitrate dehydrogenase activity
HZY74_02680	COG0583	DNA-binding transcription factor activity
HZY74_02685	COG2095	MarC family integral membrane protein
HZY74_02710	COG0501	Belongs to the peptidase M48B family
HZY74_02715	COG0612	Peptidase, M16
HZY74_02740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HZY74_02810	COG0166	Belongs to the GPI family
HZY74_02855	COG4717	serine-type aminopeptidase activity
HZY74_02860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HZY74_02865	COG0288	reversible hydration of carbon dioxide
HZY74_02870	COG0322	excinuclease ABC activity
HZY74_02880	COG3238	Protein conserved in bacteria
HZY74_02885	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_02915	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HZY74_02920	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HZY74_02925	COG4771	TonB-dependent receptor
HZY74_02930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HZY74_02935	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HZY74_02950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZY74_02965	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HZY74_02995	COG1024	Enoyl-CoA hydratase
HZY74_03020	COG0730	response to heat
HZY74_03030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZY74_03035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZY74_03035	COG0475	glutathione-regulated potassium exporter activity
HZY74_03045	COG2304	oxidoreductase activity
HZY74_03050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZY74_03050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZY74_03055	COG0588	phosphoglycerate mutase activity
HZY74_03060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZY74_03080	COG0640	Transcriptional regulator
HZY74_03095	COG0336	Belongs to the RNA methyltransferase TrmD family
HZY74_03100	COG0335	large ribosomal subunit rRNA binding
HZY74_03105	COG3483	tryptophan 2,3-dioxygenase activity
HZY74_03150	COG0741	lytic transglycosylase activity
HZY74_03150	COG0739	heme binding
HZY74_03150	COG1196	nuclear chromosome segregation
HZY74_03160	COG0596	Alpha beta hydrolase
HZY74_03175	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZY74_03190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HZY74_03205	COG2271	Major facilitator Superfamily
HZY74_03215	COG1309	transcriptional regulator
HZY74_03225	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HZY74_03240	COG2205	protein histidine kinase activity
HZY74_03255	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HZY74_03270	COG1268	BioY protein
HZY74_03275	COG0019	diaminopimelate decarboxylase activity
HZY74_03280	COG0165	Argininosuccinate lyase
HZY74_03285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HZY74_03310	COG2133	pyrroloquinoline quinone binding
HZY74_03320	COG0706	membrane insertase activity
HZY74_03330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HZY74_03340	COG0642	Histidine kinase
HZY74_03350	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HZY74_03385	COG1201	RNA secondary structure unwinding
HZY74_03390	COG1199	ATP-dependent helicase activity
HZY74_03395	COG1408	metallophosphoesterase
HZY74_03405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HZY74_03410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HZY74_03430	COG2354	Protein conserved in bacteria
HZY74_03435	COG1253	flavin adenine dinucleotide binding
HZY74_03445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HZY74_03455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HZY74_03460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZY74_03465	COG4191	Histidine kinase
HZY74_03465	COG0784	Response regulator, receiver
HZY74_03530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZY74_03550	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HZY74_03555	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HZY74_03570	COG0179	Fumarylacetoacetate (FAA) hydrolase
HZY74_03630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HZY74_03665	COG4452	Inner membrane protein CreD
HZY74_03675	COG0633	Ferredoxin
HZY74_03700	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HZY74_03745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HZY74_03755	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZY74_03800	COG5001	Diguanylate cyclase
HZY74_03800	COG1716	ATPase activity
HZY74_03810	COG3753	Protein conserved in bacteria
HZY74_03815	COG0101	tRNA pseudouridine synthase activity
HZY74_03835	COG1607	acyl-coa hydrolase
HZY74_03855	COG0587	DNA-directed DNA polymerase activity
HZY74_03890	COG1522	sequence-specific DNA binding
HZY74_03895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZY74_03895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HZY74_03895	COG0506	proline dehydrogenase activity
HZY74_03930	COG4771	TonB-dependent receptor
HZY74_03940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HZY74_03960	COG0728	peptidoglycan biosynthetic process
HZY74_03965	COG0180	Tryptophanyl-tRNA synthetase
HZY74_03980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZY74_04010	COG2267	carboxylic ester hydrolase activity
HZY74_04015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HZY74_04030	COG1999	signal sequence binding
HZY74_04050	COG0519	Catalyzes the synthesis of GMP from XMP
HZY74_04060	COG0670	Belongs to the BI1 family
HZY74_04070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZY74_04080	COG0745	RESPONSE REGULATOR receiver
HZY74_04100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HZY74_04120	COG2917	probably involved in intracellular septation
HZY74_04125	COG0552	protein localization to endoplasmic reticulum
HZY74_04135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HZY74_04145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HZY74_04155	COG4221	oxidoreductase activity
HZY74_04170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZY74_04170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZY74_04175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HZY74_04185	COG0138	bifunctional purine biosynthesis protein purh
HZY74_04205	COG0673	inositol 2-dehydrogenase activity
HZY74_04225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HZY74_04255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HZY74_04260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HZY74_04265	COG1505	serine-type exopeptidase activity
HZY74_04270	COG1505	serine-type exopeptidase activity
HZY74_04305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HZY74_04310	COG1674	ftsk spoiiie
HZY74_04330	COG1420	regulation of RNA biosynthetic process
HZY74_04340	COG0412	Dienelactone hydrolase
HZY74_04355	COG0443	Heat shock 70 kDa protein
HZY74_04360	COG0484	heat shock protein binding
HZY74_04365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HZY74_04375	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HZY74_04385	COG1396	sequence-specific DNA binding
HZY74_04390	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HZY74_04400	COG1702	phosphate starvation-inducible protein PhoH
HZY74_04405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HZY74_04425	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HZY74_04435	COG2902	Dehydrogenase
HZY74_04445	COG0433	COG0433 Predicted ATPase
HZY74_04460	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HZY74_04465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HZY74_04470	COG0237	dephospho-CoA kinase activity
HZY74_04485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HZY74_04505	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HZY74_04560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HZY74_04565	COG0745	RESPONSE REGULATOR receiver
HZY74_04580	COG1024	Enoyl-CoA hydratase
HZY74_04590	COG0268	Binds directly to 16S ribosomal RNA
HZY74_04595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HZY74_04630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HZY74_04635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HZY74_04640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HZY74_04655	COG0686	Belongs to the AlaDH PNT family
HZY74_04660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HZY74_04675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HZY74_04705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HZY74_04710	COG3422	double-strand break repair
HZY74_04715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HZY74_04730	COG0598	Magnesium transport protein CorA
HZY74_04735	COG0339	signal peptide processing
HZY74_04740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HZY74_04760	COG0542	response to heat
HZY74_04775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HZY74_04795	COG2890	protein-(glutamine-N5) methyltransferase activity
HZY74_04810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HZY74_04815	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_04820	COG0183	Belongs to the thiolase family
HZY74_04830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HZY74_04830	COG0517	IMP dehydrogenase activity
HZY74_04850	COG2096	Adenosyltransferase
HZY74_04860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HZY74_04890	COG1131	(ABC) transporter
HZY74_04900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZY74_04905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HZY74_04905	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZY74_04915	COG2205	protein histidine kinase activity
HZY74_04920	COG0745	RESPONSE REGULATOR receiver
HZY74_04935	COG2081	HI0933 family
HZY74_04945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZY74_04945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HZY74_04955	COG0346	lactoylglutathione lyase activity
HZY74_04980	COG2813	Specifically methylates the guanine in position
HZY74_04995	COG0133	tryptophan synthase activity
HZY74_05000	COG0159	tryptophan synthase activity
HZY74_05010	COG0285	dihydrofolate synthase activity
HZY74_05020	COG1074	ATP-dependent DNA helicase activity
HZY74_05035	COG3178	'Phosphotransferase
HZY74_05040	COG0802	atpase or kinase
HZY74_05045	COG1506	peptidase
HZY74_05045	COG0823	Involved in the tonB-independent uptake of proteins
HZY74_05060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HZY74_05120	COG4964	Belongs to the GSP D family
HZY74_05160	COG2130	NADP-dependent
HZY74_05180	COG0735	belongs to the Fur family
HZY74_05210	COG2957	Belongs to the agmatine deiminase family
HZY74_05225	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HZY74_05235	COG0612	Peptidase, M16
HZY74_05240	COG0612	Peptidase, M16
HZY74_05245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HZY74_05275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HZY74_05285	COG3655	Transcriptional regulator
HZY74_05295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HZY74_05300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HZY74_05305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HZY74_05315	COG0189	ligase activity
HZY74_05325	COG2205	protein histidine kinase activity
HZY74_05325	COG5002	protein histidine kinase activity
HZY74_05325	COG0784	Response regulator, receiver
HZY74_05330	COG2223	nitrite transmembrane transporter activity
HZY74_05335	COG0281	malic enzyme
HZY74_05335	COG0280	phosphate acetyltransferase
HZY74_05340	COG1185	polyribonucleotide nucleotidyltransferase activity
HZY74_05350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HZY74_05390	COG0779	Required for maturation of 30S ribosomal subunits
HZY74_05405	COG2884	Cell division ATP-binding protein ftsE
HZY74_05420	COG0204	Acyl-transferase
HZY74_05430	COG0671	phosphoesterase, PA-phosphatase related
HZY74_05455	COG1086	Polysaccharide biosynthesis protein
HZY74_05460	COG0582	viral genome integration into host DNA
HZY74_05540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HZY74_05545	COG2321	neutral zinc metallopeptidase
HZY74_05560	COG1671	Belongs to the UPF0178 family
HZY74_05610	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HZY74_05650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HZY74_05670	COG0494	nUDIX hydrolase
HZY74_05675	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HZY74_05685	COG0653	protein targeting
HZY74_05705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HZY74_05710	COG0799	negative regulation of ribosome biogenesis
HZY74_05715	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HZY74_05725	COG0793	Belongs to the peptidase S41A family
HZY74_05755	COG0784	Response regulator, receiver
HZY74_05765	COG1473	amidohydrolase
HZY74_05770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZY74_05775	COG2267	carboxylic ester hydrolase activity
HZY74_05800	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZY74_05800	COG1024	Enoyl-CoA hydratase
HZY74_05805	COG0183	Belongs to the thiolase family
HZY74_05815	COG1088	dTDP-glucose 4,6-dehydratase activity
HZY74_05835	COG0072	phenylalanine-tRNA ligase activity
HZY74_05835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HZY74_05845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HZY74_05855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HZY74_05875	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HZY74_05890	COG0596	Alpha beta hydrolase
HZY74_05895	COG1297	OPT oligopeptide transporter protein
HZY74_05905	COG2261	transglycosylase associated protein
HZY74_05980	COG0203	ribosomal protein L17
HZY74_06000	COG1131	(ABC) transporter
HZY74_06020	COG0574	Belongs to the PEP-utilizing enzyme family
HZY74_06020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HZY74_06030	COG3104	oligopeptide transport
HZY74_06060	COG1749	Flagellar hook protein flgE
HZY74_06065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HZY74_06085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HZY74_06090	COG1127	ABC transporter
HZY74_06095	COG3218	ABC-type transport auxiliary lipoprotein component
HZY74_06095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HZY74_06180	COG1228	amidohydrolase
HZY74_06185	COG0183	Belongs to the thiolase family
HZY74_06215	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HZY74_06230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HZY74_06235	COG0457	Tetratricopeptide repeat
HZY74_06235	COG0859	PFAM glycosyl transferase family 9
HZY74_06245	COG5442	Flagellar protein FlaF
HZY74_06250	COG3932	Exopolysaccharide synthesis, ExoD
HZY74_06265	COG1960	acyl-CoA dehydrogenase activity
HZY74_06280	COG2239	Acts as a magnesium transporter
HZY74_06310	COG1064	alcohol dehydrogenase
HZY74_06315	COG1278	Cold shock
HZY74_06320	COG0745	RESPONSE REGULATOR receiver
HZY74_06355	COG4770	biotin carboxylase activity
HZY74_06400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HZY74_06405	COG0424	maF-like protein
HZY74_06415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HZY74_06430	COG0848	biopolymer transport protein
HZY74_06450	COG1686	Belongs to the peptidase S11 family
HZY74_06460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HZY74_06490	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HZY74_06505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HZY74_06540	COG1960	acyl-CoA dehydrogenase activity
HZY74_06550	COG1960	acyl-CoA dehydrogenase activity
HZY74_06555	COG0789	Transcriptional regulator
HZY74_06560	COG0668	transmembrane transport
HZY74_06585	COG0545	Peptidyl-prolyl cis-trans isomerase
HZY74_06615	COG2132	Multicopper oxidase
HZY74_06660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HZY74_06685	COG1253	flavin adenine dinucleotide binding
HZY74_06720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HZY74_06725	COG0081	regulation of translation
HZY74_06740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HZY74_06745	COG0222	ribosome binding
HZY74_06750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HZY74_06765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HZY74_06770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HZY74_06775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HZY74_06785	COG0194	GDP metabolic process
HZY74_06795	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HZY74_06800	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HZY74_06825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HZY74_06865	COG0488	(ABC) transporter
HZY74_06890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HZY74_06895	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HZY74_06910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HZY74_06925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HZY74_06940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HZY74_06955	COG0439	Biotin carboxylase
HZY74_06965	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HZY74_06980	COG2022	thiamine diphosphate biosynthetic process
HZY74_07000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HZY74_07030	COG0187	DNA topoisomerase II activity
HZY74_07045	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HZY74_07050	COG2022	thiamine diphosphate biosynthetic process
HZY74_07050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZY74_07075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HZY74_07085	COG0235	Class ii aldolase
HZY74_07100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HZY74_07110	COG1918	ferrous iron import across plasma membrane
HZY74_07110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HZY74_07135	COG5265	(ABC) transporter
HZY74_07155	COG4974	Belongs to the 'phage' integrase family
HZY74_07160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HZY74_07165	COG0668	transmembrane transport
HZY74_07180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZY74_07205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HZY74_07235	COG0438	transferase activity, transferring glycosyl groups
HZY74_07245	COG0784	Response regulator, receiver
HZY74_07245	COG2198	Histidine kinase
HZY74_07245	COG2205	protein histidine kinase activity
HZY74_07265	COG0649	NAD binding
HZY74_07305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HZY74_07310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HZY74_07335	COG1007	ATP synthesis coupled electron transport
HZY74_07345	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HZY74_07360	COG2234	aminopeptidase activity
HZY74_07365	COG0346	lactoylglutathione lyase activity
HZY74_07370	COG0442	prolyl-tRNA aminoacylation
HZY74_07375	COG4591	ABC-type transport system involved in lipoprotein release permease component
HZY74_07380	COG1136	(ABC) transporter
HZY74_07405	COG0528	UMP kinase activity
HZY74_07410	COG0233	cytoplasmic translational termination
HZY74_07415	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HZY74_07435	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HZY74_07450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HZY74_07460	COG3494	Protein of unknown function (DUF1009)
HZY74_07465	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZY74_07470	COG0372	Belongs to the citrate synthase family
HZY74_07475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZY74_07485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HZY74_07490	COG1923	regulation of RNA biosynthetic process
HZY74_07495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HZY74_07510	COG0668	transmembrane transport
HZY74_07525	COG3956	TIGRFAM MazG family protein
HZY74_07530	COG2211	Major facilitator Superfamily
HZY74_07545	COG3384	dioxygenase
HZY74_07550	COG0204	Acyl-transferase
HZY74_07550	COG0318	PFAM AMP-dependent synthetase and ligase
HZY74_07560	COG2867	negative regulation of translational initiation
HZY74_07565	COG4993	Dehydrogenase
HZY74_07575	COG0579	oxidoreductase
HZY74_07600	COG0148	phosphopyruvate hydratase activity
HZY74_07610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HZY74_07615	COG0022	dehydrogenase e1 component
HZY74_07615	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZY74_07630	COG0508	dehydrogenase complex catalyzes the overall conversion of
HZY74_07635	COG0386	Belongs to the glutathione peroxidase family
HZY74_07640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZY74_07655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HZY74_07660	COG0084	hydrolase, TatD family'
HZY74_07670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HZY74_07675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HZY74_07695	COG2084	Dehydrogenase
HZY74_07705	COG1360	Flagellar Motor Protein
HZY74_07710	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HZY74_07715	COG0501	Belongs to the peptidase M48B family
HZY74_07720	COG1704	LemA family
HZY74_07725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZY74_07765	COG0681	Belongs to the peptidase S26 family
HZY74_07770	COG0736	holo-[acyl-carrier-protein] synthase activity
HZY74_07775	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HZY74_07780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HZY74_07790	COG1611	Belongs to the LOG family
HZY74_07805	COG1024	Enoyl-CoA hydratase
HZY74_07815	COG1960	acyl-CoA dehydrogenase activity
HZY74_07820	COG0113	porphobilinogen synthase activity
HZY74_07825	COG0504	CTP synthase activity
HZY74_07835	COG0149	triose-phosphate isomerase activity
HZY74_07845	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HZY74_07855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HZY74_07860	COG0134	indole-3-glycerol-phosphate synthase activity
HZY74_07870	COG2204	response regulator
HZY74_07875	COG5000	phosphorelay sensor kinase activity
HZY74_07880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HZY74_07895	COG1058	Belongs to the CinA family
HZY74_07895	COG1546	Belongs to the CinA family
HZY74_07905	COG1295	ribonuclease BN
HZY74_07920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HZY74_07930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZY74_07935	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HZY74_07935	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HZY74_07945	COG2897	thiosulfate sulfurtransferase activity
HZY74_07950	COG1301	dicarboxylic acid transport
HZY74_07955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HZY74_07985	COG1278	Cold shock
HZY74_07995	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HZY74_07995	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HZY74_08005	COG3243	poly(R)-hydroxyalkanoic acid synthase
HZY74_08020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HZY74_08035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HZY74_08040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HZY74_08070	COG0776	regulation of translation
HZY74_08100	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HZY74_08110	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HZY74_08120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HZY74_08135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZY74_08135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HZY74_08140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HZY74_08145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HZY74_08155	COG0156	8-amino-7-oxononanoate synthase activity
HZY74_08180	COG4783	chaperone-mediated protein folding
HZY74_08195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HZY74_08200	COG1388	LysM domain
HZY74_08200	COG0741	lytic transglycosylase activity
HZY74_08205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HZY74_08210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HZY74_08225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HZY74_08230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HZY74_08230	COG0116	Belongs to the methyltransferase superfamily
HZY74_08245	COG0531	amino acid
HZY74_08350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HZY74_08365	COG0525	valine-tRNA ligase activity
HZY74_08405	COG1611	Belongs to the LOG family
HZY74_08415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZY74_08435	COG1706	bacterial-type flagellum-dependent cell motility
HZY74_08460	COG0456	acetyltransferase
HZY74_08465	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HZY74_08490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HZY74_08510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HZY74_08520	COG0154	amidase activity
HZY74_08590	COG3104	oligopeptide transport
HZY74_08615	COG1053	succinate dehydrogenase
HZY74_08615	COG3976	FMN-binding domain protein
HZY74_08620	COG4771	TonB-dependent receptor
HZY74_08625	COG2814	Major facilitator Superfamily
HZY74_08650	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_08665	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_08670	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_08680	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_08685	COG1802	Transcriptional regulator
HZY74_08690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HZY74_08700	COG3485	protocatechuate 3,4-dioxygenase
HZY74_08710	COG0318	PFAM AMP-dependent synthetase and ligase
HZY74_08725	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HZY74_08735	COG5285	phytanoyl-CoA dioxygenase
HZY74_08745	COG1960	acyl-CoA dehydrogenase activity
HZY74_08765	COG2146	nitrite reductase [NAD(P)H] activity
HZY74_08775	COG2188	Transcriptional regulator
HZY74_08790	COG1960	acyl-CoA dehydrogenase activity
HZY74_08800	COG0183	Belongs to the thiolase family
HZY74_08805	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_08810	COG1250	3-hydroxyacyl-CoA dehydrogenase
HZY74_08810	COG1024	Enoyl-CoA hydratase
HZY74_08815	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_08820	COG1024	Enoyl-CoA hydratase
HZY74_08830	COG1024	Enoyl-CoA hydratase
HZY74_08850	COG1960	acyl-CoA dehydrogenase activity
HZY74_08855	COG0579	oxidoreductase
HZY74_08970	COG1228	amidohydrolase
HZY74_08985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HZY74_08990	COG2986	histidine ammonia-lyase
HZY74_09005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HZY74_09055	COG2363	Small membrane protein
HZY74_09100	COG0482	sulfurtransferase activity
HZY74_09130	COG4942	peptidase
HZY74_09135	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HZY74_09150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HZY74_09160	COG0784	Response regulator, receiver
HZY74_09160	COG2205	protein histidine kinase activity
HZY74_09160	COG5002	protein histidine kinase activity
HZY74_09195	COG1960	acyl-CoA dehydrogenase activity
HZY74_09210	COG0174	glutamine synthetase
HZY74_09225	COG0805	protein transport
HZY74_09230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZY74_09235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HZY74_09260	COG0330	HflC and HflK could
HZY74_09280	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_09295	COG0009	L-threonylcarbamoyladenylate synthase
HZY74_09305	COG1960	acyl-CoA dehydrogenase activity
HZY74_09340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HZY74_09345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HZY74_09365	COG0393	Putative heavy-metal-binding
HZY74_09375	COG0489	protein tyrosine kinase activity
HZY74_09380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HZY74_09430	COG0114	fumarate hydratase activity
HZY74_09445	COG0494	nUDIX hydrolase
HZY74_09510	COG1309	transcriptional regulator
HZY74_09520	COG2818	Glycosylase
HZY74_09540	COG1187	pseudouridine synthase activity
HZY74_09545	COG0154	amidase activity
HZY74_09565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HZY74_09575	COG0540	Belongs to the ATCase OTCase family
HZY74_09600	COG0758	DNA mediated transformation
HZY74_09610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HZY74_09610	COG1754	DNA topoisomerase type I activity
HZY74_09635	COG2755	lipolytic protein G-D-S-L family
HZY74_09635	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HZY74_09760	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZY74_09765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HZY74_09770	COG0742	ribosomal rna small subunit methyltransferase
HZY74_09775	COG3548	integral membrane protein
HZY74_09780	COG1187	pseudouridine synthase activity
HZY74_09805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HZY74_09815	COG0588	phosphoglycerate mutase activity
HZY74_09825	COG0167	dihydroorotate dehydrogenase activity
HZY74_09855	COG0612	Peptidase, M16
HZY74_09860	COG3346	SURF1 family
HZY74_09870	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HZY74_09880	COG0109	protoheme IX farnesyltransferase activity
HZY74_09885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HZY74_09945	COG0210	DNA helicase
HZY74_09950	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HZY74_09970	COG1475	DNA binding
HZY74_10010	COG5489	Protein of unknown function (DUF736)
HZY74_10080	COG4962	Type ii secretion system protein e
HZY74_10175	COG0556	nucleotide-excision repair
HZY74_10210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HZY74_10210	COG0519	Catalyzes the synthesis of GMP from XMP
HZY74_10215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HZY74_10215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HZY74_10260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HZY74_10270	COG0667	Aldo Keto reductase
HZY74_10275	COG0006	proline dipeptidase activity
HZY74_10280	COG2264	protein methyltransferase activity
HZY74_10295	COG0778	Nitroreductase
HZY74_10300	COG1032	radical SAM domain protein
HZY74_10315	COG0640	Transcriptional regulator
HZY74_10320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HZY74_10335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HZY74_10355	COG0626	cystathionine gamma-synthase activity
HZY74_10365	COG0557	exoribonuclease II activity
HZY74_10400	COG0215	cysteine-tRNA ligase activity
HZY74_10405	COG0302	gtp cyclohydrolase
HZY74_10410	COG0848	biopolymer transport protein
HZY74_10420	COG0656	L-ascorbic acid biosynthetic process
HZY74_10425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HZY74_10480	COG0312	modulator of DNA gyrase
HZY74_10505	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HZY74_10505	COG3264	Mechanosensitive ion channel
HZY74_10515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HZY74_10525	COG0556	nucleotide-excision repair
HZY74_10550	COG0360	Binds together with S18 to 16S ribosomal RNA
HZY74_10555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HZY74_10560	COG0359	binds to the 23S rRNA
HZY74_10570	COG0305	Participates in initiation and elongation during chromosome replication
HZY74_10580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HZY74_10605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HZY74_10610	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_10620	COG1160	GTP binding
HZY74_10635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HZY74_10655	COG1393	Belongs to the ArsC family
HZY74_10675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HZY74_10680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZY74_10685	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HZY74_10695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HZY74_10715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HZY74_10740	COG0018	arginyl-trna synthetase
HZY74_10750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HZY74_10755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HZY74_10775	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HZY74_10780	COG0316	Belongs to the HesB IscA family
HZY74_10785	COG4774	siderophore transport
HZY74_10800	COG1715	Restriction endonuclease
HZY74_10820	COG0564	pseudouridine synthase activity
HZY74_10845	COG0564	pseudouridine synthase activity
HZY74_10865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HZY74_10885	COG0142	geranyltranstransferase activity
HZY74_10900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZY74_10910	COG0123	including yeast histone deacetylase and acetoin utilization protein
HZY74_10965	COG2942	2-epimerase
HZY74_10975	COG0489	protein tyrosine kinase activity
HZY74_10975	COG3206	protein involved in exopolysaccharide biosynthesis
HZY74_10975	COG0489	protein tyrosine kinase activity
HZY74_10975	COG3206	protein involved in exopolysaccharide biosynthesis
HZY74_11010	COG3128	pkhd-type hydroxylase
HZY74_11020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HZY74_11055	COG0745	RESPONSE REGULATOR receiver
HZY74_11070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HZY74_11085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HZY74_11100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HZY74_11110	COG4771	TonB-dependent receptor
HZY74_11115	COG0849	cell division
HZY74_11125	COG1181	Belongs to the D-alanine--D-alanine ligase family
HZY74_11150	COG1959	2 iron, 2 sulfur cluster binding
HZY74_11170	COG2860	membrane
HZY74_11180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HZY74_11200	COG1278	Cold shock
HZY74_11210	COG0625	glutathione transferase activity
HZY74_11255	COG1733	regulation of RNA biosynthetic process
HZY74_11275	COG5507	3-demethylubiquinone-9 3-methyltransferase
HZY74_11290	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HZY74_11295	COG0358	DNA primase activity
HZY74_11305	COG0505	Belongs to the CarA family
HZY74_11310	COG0531	amino acid
HZY74_11330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HZY74_11350	COG1823	symporter activity
HZY74_11360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HZY74_11375	COG0492	ferredoxin-NADP+ reductase activity
HZY74_11385	COG3920	Histidine kinase
HZY74_11410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HZY74_11435	COG3273	potassium ion transport
HZY74_11435	COG0471	metal ion transport
HZY74_11460	COG1131	(ABC) transporter
HZY74_11465	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HZY74_11495	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HZY74_11525	COG3023	N-Acetylmuramoyl-L-alanine amidase
HZY74_11535	COG0616	signal peptide processing
HZY74_11540	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HZY74_11550	COG2968	Membrane
HZY74_11560	COG1956	GAF domain-containing protein
HZY74_11590	COG0142	geranyltranstransferase activity
HZY74_11595	COG2890	protein-(glutamine-N5) methyltransferase activity
HZY74_11600	COG1132	(ABC) transporter
HZY74_11605	COG0254	rRNA binding
HZY74_11625	COG3321	synthase
HZY74_11625	COG0604	alcohol dehydrogenase
HZY74_11625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HZY74_11625	COG4221	oxidoreductase activity
HZY74_11645	COG0163	prenyltransferase activity
HZY74_11660	COG3706	GGDEF domain
HZY74_11665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HZY74_11670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HZY74_11680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HZY74_11690	COG4152	abc transporter atp-binding protein
HZY74_11695	COG0739	heme binding
HZY74_11700	COG3240	lipase activity
HZY74_11705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HZY74_11710	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_11725	COG0745	RESPONSE REGULATOR receiver
HZY74_11740	COG0581	inorganic phosphate transmembrane transporter activity
HZY74_11745	COG0573	inorganic phosphate transmembrane transporter activity
HZY74_11750	COG5002	protein histidine kinase activity
HZY74_11760	COG2224	Isocitrate lyase
HZY74_11810	COG0457	Tetratricopeptide repeat
HZY74_11820	COG0151	Belongs to the GarS family
HZY74_11845	COG1028	Short-chain dehydrogenase reductase Sdr
HZY74_11850	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HZY74_11865	COG0196	riboflavin kinase activity
HZY74_11870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HZY74_11910	COG1573	uracil-dna glycosylase
HZY74_11940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HZY74_11950	COG2226	methyltransferase
HZY74_11980	COG0789	Transcriptional regulator
HZY74_12015	COG0318	PFAM AMP-dependent synthetase and ligase
HZY74_12030	COG0259	pyridoxamine-phosphate oxidase activity
HZY74_12040	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HZY74_12045	COG1741	Belongs to the pirin family
HZY74_12060	COG2267	carboxylic ester hydrolase activity
HZY74_12075	COG0602	queuosine metabolic process
HZY74_12120	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HZY74_12145	COG0729	surface antigen
HZY74_12165	COG3138	arginine N-succinyltransferase
HZY74_12170	COG1012	belongs to the aldehyde dehydrogenase family
HZY74_12175	COG2852	Protein conserved in bacteria
HZY74_12180	COG3724	N-succinylarginine dihydrolase activity
HZY74_12185	COG1677	Flagellar hook-basal body complex protein FliE
HZY74_12190	COG1558	bacterial-type flagellum-dependent cell motility
HZY74_12200	COG3190	flagellar
HZY74_12205	COG1338	Plays a role in the flagellum-specific transport system
HZY74_12210	COG0776	regulation of translation
HZY74_12240	COG3104	oligopeptide transport
HZY74_12245	COG1970	mechanosensitive ion channel activity
HZY74_12255	COG0539	negative regulation of cytoplasmic translation
HZY74_12310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HZY74_12310	COG2885	chlorophyll binding
HZY74_12325	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HZY74_12365	COG0523	cobalamin synthesis protein
HZY74_12380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HZY74_12385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HZY74_12390	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HZY74_12405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HZY74_12415	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HZY74_12440	COG1968	undecaprenyl-diphosphatase activity
HZY74_12470	COG1137	ATPase activity
HZY74_12475	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HZY74_12480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HZY74_12485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HZY74_12495	COG0071	Belongs to the small heat shock protein (HSP20) family
HZY74_12510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HZY74_12550	COG2171	N-acyltransferase activity
HZY74_12570	COG0842	Transport permease protein
HZY74_12575	COG1131	(ABC) transporter
HZY74_12595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HZY74_12605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HZY74_12605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HZY74_12620	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HZY74_12630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HZY74_12640	COG0004	ammonium transporteR
HZY74_12655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HZY74_12660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HZY74_12675	COG0513	Belongs to the DEAD box helicase family
HZY74_12680	COG3485	protocatechuate 3,4-dioxygenase
HZY74_12695	COG1546	Belongs to the CinA family
HZY74_12695	COG1058	Belongs to the CinA family
HZY74_12700	COG1446	asparaginase
HZY74_12725	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HZY74_12735	COG1234	tRNA 3'-trailer cleavage
HZY74_12755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HZY74_12760	COG3300	MHYT domain
HZY74_12760	COG5001	Diguanylate cyclase
HZY74_12765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HZY74_12790	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HZY74_12800	COG0583	DNA-binding transcription factor activity
HZY74_12815	COG1971	Probably functions as a manganese efflux pump
HZY74_12840	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HZY74_12845	COG1301	dicarboxylic acid transport
HZY74_12860	COG1476	TRANSCRIPTIONal
HZY74_12875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HZY74_12880	COG0673	inositol 2-dehydrogenase activity
HZY74_12885	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HZY74_12910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HZY74_12925	COG0367	asparagine synthase
HZY74_12950	COG0482	sulfurtransferase activity
HZY74_12970	COG3958	Transketolase
HZY74_12985	COG0667	Aldo Keto reductase
HZY74_13005	COG2733	membrane
HZY74_13065	COG3214	Protein conserved in bacteria
HZY74_13070	COG0842	Transport permease protein
HZY74_13100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HZY74_13105	COG2816	NAD+ diphosphatase activity
HZY74_13140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HZY74_13145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HZY74_13165	COG0625	glutathione transferase activity
HZY74_13180	COG0312	modulator of DNA gyrase
HZY74_13195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HZY74_13215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HZY74_13220	COG0248	Ppx GppA phosphatase
HZY74_13230	COG3186	Phenylalanine-4-hydroxylase
HZY74_13235	COG0302	gtp cyclohydrolase
HZY74_13250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HZY74_13270	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HZY74_13285	COG1476	TRANSCRIPTIONal
HZY74_13310	COG2264	protein methyltransferase activity
HZY74_13320	COG2321	neutral zinc metallopeptidase
HZY74_13330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HZY74_13335	COG1619	proteins homologs of microcin C7 resistance protein MccF
HZY74_13340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HZY74_13360	COG1477	protein flavinylation
HZY74_13370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HZY74_13375	COG0363	glucosamine-6-phosphate deaminase activity
HZY74_13400	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HZY74_13410	COG1136	(ABC) transporter
HZY74_13485	COG1566	PFAM secretion protein HlyD family protein
HZY74_13505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HZY74_13530	COG1522	sequence-specific DNA binding
HZY74_13535	COG1741	Belongs to the pirin family
HZY74_13570	COG0071	Belongs to the small heat shock protein (HSP20) family