locus-tag	class	description
GHC20_00005	COG0628	permease
GHC20_00025	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_00035	COG1620	l-lactate permease
GHC20_00070	COG0626	cystathionine gamma-synthase activity
GHC20_00080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHC20_00085	COG4597	amino acid ABC transporter
GHC20_00090	COG0765	amino acid transport
GHC20_00095	COG1126	abc transporter atp-binding protein
GHC20_00110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GHC20_00120	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GHC20_00135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GHC20_00150	COG0113	porphobilinogen synthase activity
GHC20_00170	COG2989	Protein conserved in bacteria
GHC20_00185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHC20_00185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GHC20_00195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GHC20_00205	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GHC20_00210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHC20_00245	COG2076	Multidrug Resistance protein
GHC20_00290	COG0010	Belongs to the arginase family
GHC20_00335	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GHC20_00355	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
GHC20_00360	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GHC20_00400	COG1007	ATP synthesis coupled electron transport
GHC20_00440	COG0587	DNA-directed DNA polymerase activity
GHC20_00470	COG1487	ribonuclease activity
GHC20_00480	COG0483	inositol monophosphate 1-phosphatase activity
GHC20_00485	COG2814	Major facilitator Superfamily
GHC20_00520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GHC20_00545	COG2514	catechol 2,3-dioxygenase activity
GHC20_00550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GHC20_00570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHC20_00575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHC20_00580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GHC20_00595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHC20_00600	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GHC20_00605	COG3454	Phosphonate metabolism
GHC20_00645	COG1760	l-serine dehydratase
GHC20_00660	COG1686	Belongs to the peptidase S11 family
GHC20_00675	COG0537	adenosine 5'-monophosphoramidase activity
GHC20_00685	COG0584	glycerophosphoryl diester phosphodiesterase
GHC20_00740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHC20_00765	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GHC20_00770	COG0372	Belongs to the citrate synthase family
GHC20_00780	COG2333	competence protein COMEC
GHC20_00780	COG0658	competence protein
GHC20_00790	COG0303	'Molybdopterin
GHC20_00810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHC20_00845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GHC20_00850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GHC20_00855	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHC20_00855	COG0022	dehydrogenase e1 component
GHC20_00860	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHC20_00865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GHC20_00880	COG2867	negative regulation of translational initiation
GHC20_00885	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_00890	COG1546	Belongs to the CinA family
GHC20_00890	COG1058	Belongs to the CinA family
GHC20_00905	COG3852	Histidine kinase
GHC20_00910	COG2204	response regulator
GHC20_00915	COG5000	phosphorelay sensor kinase activity
GHC20_00920	COG2204	response regulator
GHC20_00925	COG0569	domain protein
GHC20_00945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GHC20_00970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GHC20_00985	COG2188	Transcriptional regulator
GHC20_00995	COG2095	MarC family integral membrane protein
GHC20_01000	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GHC20_01010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GHC20_01015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GHC20_01025	COG0343	queuine tRNA-ribosyltransferase activity
GHC20_01035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHC20_01040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHC20_01045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHC20_01050	COG0583	DNA-binding transcription factor activity
GHC20_01055	COG1960	acyl-CoA dehydrogenase activity
GHC20_01060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHC20_01070	COG3617	BRO family, N-terminal domain
GHC20_01085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GHC20_01100	COG0328	RNA-DNA hybrid ribonuclease activity
GHC20_01135	COG1752	Esterase of the alpha-beta hydrolase superfamily
GHC20_01180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GHC20_01185	COG3956	TIGRFAM MazG family protein
GHC20_01190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GHC20_01200	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GHC20_01205	COG0006	proline dipeptidase activity
GHC20_01215	COG1566	PFAM secretion protein HlyD family protein
GHC20_01220	COG2814	Major facilitator Superfamily
GHC20_01225	COG0427	acetyl-CoA hydrolase
GHC20_01230	COG3706	GGDEF domain
GHC20_01240	COG2897	thiosulfate sulfurtransferase activity
GHC20_01245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GHC20_01250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GHC20_01255	COG0513	Belongs to the DEAD box helicase family
GHC20_01260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GHC20_01275	COG1058	Belongs to the CinA family
GHC20_01275	COG1546	Belongs to the CinA family
GHC20_01295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GHC20_01300	COG0668	transmembrane transport
GHC20_01310	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
GHC20_01325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GHC20_01335	COG3106	COG3106 Predicted ATPase
GHC20_01350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GHC20_01360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GHC20_01370	COG0492	ferredoxin-NADP+ reductase activity
GHC20_01375	COG0633	Ferredoxin
GHC20_01395	COG1127	ABC transporter
GHC20_01400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GHC20_01405	COG4948	Mandelate Racemase Muconate Lactonizing
GHC20_01410	COG0280	phosphate acetyltransferase
GHC20_01410	COG0281	malic enzyme
GHC20_01430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GHC20_01435	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GHC20_01455	COG0546	phosphoglycolate phosphatase activity
GHC20_01465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GHC20_01465	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GHC20_01470	COG0347	Belongs to the P(II) protein family
GHC20_01475	COG0174	glutamine synthetase
GHC20_01510	COG0084	hydrolase, TatD family'
GHC20_01540	COG1393	Belongs to the ArsC family
GHC20_01625	COG3561	AntA/AntB antirepressor
GHC20_01740	COG1802	Transcriptional regulator
GHC20_01740	COG4626	Terminase
GHC20_01780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GHC20_01785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GHC20_01815	COG3750	Belongs to the UPF0335 family
GHC20_01955	COG2989	Protein conserved in bacteria
GHC20_02005	COG0625	glutathione transferase activity
GHC20_02010	COG2084	Dehydrogenase
GHC20_02035	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHC20_02055	COG0316	Belongs to the HesB IscA family
GHC20_02060	COG0513	Belongs to the DEAD box helicase family
GHC20_02080	COG2151	metal-sulfur cluster biosynthetic enzyme
GHC20_02085	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GHC20_02090	COG0719	Fe-S assembly protein
GHC20_02095	COG0396	ATPase activity
GHC20_02100	COG0719	Fe-S assembly protein
GHC20_02110	COG2945	thiolester hydrolase activity
GHC20_02135	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GHC20_02140	COG2833	Protein of unknown function (DUF455)
GHC20_02155	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GHC20_02160	COG0860	N-Acetylmuramoyl-L-alanine amidase
GHC20_02170	COG1530	ribonuclease E activity
GHC20_02180	COG0501	Belongs to the peptidase M48B family
GHC20_02195	COG0511	ligase activity, forming carbon-carbon bonds
GHC20_02200	COG0439	Biotin carboxylase
GHC20_02210	COG4765	Protein conserved in bacteria
GHC20_02230	COG0544	peptidyl-prolyl cis-trans isomerase activity
GHC20_02255	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GHC20_02290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GHC20_02305	COG0805	protein transport
GHC20_02310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GHC20_02320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GHC20_02325	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GHC20_02330	COG1472	Belongs to the glycosyl hydrolase 3 family
GHC20_02350	COG0316	Belongs to the HesB IscA family
GHC20_02375	COG1573	uracil-dna glycosylase
GHC20_02380	COG1522	sequence-specific DNA binding
GHC20_02405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GHC20_02410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHC20_02415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHC20_02430	COG3800	Transcriptional regulator
GHC20_02430	COG1396	sequence-specific DNA binding
GHC20_02435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHC20_02440	COG0439	Biotin carboxylase
GHC20_02475	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
GHC20_02480	COG0693	protein deglycase activity
GHC20_02490	COG0538	isocitrate dehydrogenase activity
GHC20_02495	COG1785	Belongs to the alkaline phosphatase family
GHC20_02510	COG2885	chlorophyll binding
GHC20_02520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GHC20_02525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHC20_02545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GHC20_02750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHC20_02755	COG0516	GMP reductase activity
GHC20_02755	COG0517	IMP dehydrogenase activity
GHC20_02805	COG1278	Cold shock
GHC20_02815	COG0346	lactoylglutathione lyase activity
GHC20_02835	COG1494	fructose-1,6-bisphosphatase
GHC20_02845	COG0436	Aminotransferase
GHC20_02880	COG0024	Methionine aminopeptidase
GHC20_02930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GHC20_03050	COG0583	DNA-binding transcription factor activity
GHC20_03070	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GHC20_03070	COG3264	Mechanosensitive ion channel
GHC20_03085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GHC20_03085	COG4651	solute:proton antiporter activity
GHC20_03100	COG4208	sulfate ABC transporter
GHC20_03105	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GHC20_03110	COG4150	thiosulfate binding
GHC20_03120	COG1253	flavin adenine dinucleotide binding
GHC20_03125	COG0586	Pfam SNARE associated Golgi protein
GHC20_03430	COG4154	Belongs to the RbsD FucU family
GHC20_03445	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_03460	COG1120	ATPase activity
GHC20_03465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHC20_03475	COG4206	TonB-dependent receptor
GHC20_03480	COG0842	Transport permease protein
GHC20_03485	COG0842	Transport permease protein
GHC20_03485	COG1129	ABC transporter
GHC20_03490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHC20_03530	COG0829	nickel cation binding
GHC20_03535	COG4413	Urea transporter
GHC20_03545	COG0310	cobalt ion transport
GHC20_03585	COG0384	phenazine biosynthesis protein PhzF
GHC20_03610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GHC20_03630	COG3158	transport of potassium into the cell
GHC20_03645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GHC20_03650	COG0440	acetolactate synthase activity
GHC20_03655	COG0028	Belongs to the TPP enzyme family
GHC20_03665	COG0560	Phosphoserine phosphatase
GHC20_03670	COG2081	HI0933 family
GHC20_03685	COG0330	HflC and HflK could
GHC20_03765	COG4626	Terminase
GHC20_03765	COG1802	Transcriptional regulator
GHC20_03785	COG2814	Major facilitator Superfamily
GHC20_03815	COG0277	FAD linked oxidase domain protein
GHC20_03830	COG0210	DNA helicase
GHC20_03845	COG1999	signal sequence binding
GHC20_03855	COG0006	proline dipeptidase activity
GHC20_03875	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GHC20_03885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GHC20_03890	COG0849	cell division
GHC20_03895	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GHC20_03900	COG1181	Belongs to the D-alanine--D-alanine ligase family
GHC20_03960	COG3328	transposase activity
GHC20_03965	COG1914	H( )-stimulated, divalent metal cation uptake system
GHC20_03980	COG3023	N-Acetylmuramoyl-L-alanine amidase
GHC20_03985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GHC20_04015	COG0640	Transcriptional regulator
GHC20_04025	COG0477	Major facilitator Superfamily
GHC20_04045	COG2267	carboxylic ester hydrolase activity
GHC20_04070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GHC20_04075	COG2824	Alkylphosphonate utilization operon protein PhnA
GHC20_04080	COG1335	isochorismatase
GHC20_04095	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GHC20_04125	COG1475	DNA binding
GHC20_04135	COG2801	Transposase and inactivated derivatives
GHC20_04140	COG2842	Transposition protein
GHC20_04190	COG4382	Mu-like prophage protein Gp16
GHC20_04245	COG4373	Mu-like prophage FluMu protein gp28
GHC20_04250	COG4383	Mu-like prophage protein gp29
GHC20_04255	COG2369	cell adhesion
GHC20_04400	COG2968	Membrane
GHC20_04420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHC20_04425	COG0358	DNA primase activity
GHC20_04445	COG2321	neutral zinc metallopeptidase
GHC20_04470	COG1278	Cold shock
GHC20_04475	COG0625	glutathione transferase activity
GHC20_04495	COG0583	DNA-binding transcription factor activity
GHC20_04500	COG0492	ferredoxin-NADP+ reductase activity
GHC20_04505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GHC20_04515	COG1522	sequence-specific DNA binding
GHC20_04555	COG1607	acyl-coa hydrolase
GHC20_04565	COG0556	nucleotide-excision repair
GHC20_04575	COG1278	Cold shock
GHC20_04585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GHC20_04595	COG1846	Transcriptional regulator
GHC20_04600	COG0745	RESPONSE REGULATOR receiver
GHC20_04605	COG2205	protein histidine kinase activity
GHC20_04610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GHC20_04645	COG0006	proline dipeptidase activity
GHC20_04655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GHC20_04675	COG0012	GTP binding
GHC20_04680	COG2030	dehydratase
GHC20_04695	COG2857	Cytochrome c1
GHC20_04695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GHC20_04710	COG1132	(ABC) transporter
GHC20_04715	COG1132	(ABC) transporter
GHC20_04720	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GHC20_04740	COG3153	acetyltransferase
GHC20_04750	COG0617	tRNA 3'-terminal CCA addition
GHC20_04765	COG0714	Associated with various cellular activities
GHC20_04790	COG0435	Glutathione S-transferase
GHC20_04795	COG3047	cAMP biosynthetic process
GHC20_04800	COG1051	belongs to the nudix hydrolase family
GHC20_04815	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GHC20_04820	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GHC20_04820	COG0512	Glutamine amidotransferase of anthranilate synthase
GHC20_04830	COG1522	sequence-specific DNA binding
GHC20_04860	COG4176	ABC-type proline glycine betaine transport system permease component
GHC20_04865	COG4175	Glycine betaine
GHC20_04870	COG4608	Belongs to the ABC transporter superfamily
GHC20_04875	COG0444	Belongs to the ABC transporter superfamily
GHC20_04880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHC20_04885	COG0601	transmembrane transport
GHC20_04890	COG0747	negative chemotaxis
GHC20_05240	COG2205	protein histidine kinase activity
GHC20_05250	COG1177	transmembrane transport
GHC20_05255	COG1176	ABC-type spermidine putrescine transport system, permease component I
GHC20_05260	COG3842	ATPase activity
GHC20_05275	COG2224	Isocitrate lyase
GHC20_05290	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_05295	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_05310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GHC20_05325	COG1461	Dihydroxyacetone kinase
GHC20_05330	COG2376	Dihydroxyacetone kinase
GHC20_05335	COG1461	Dihydroxyacetone kinase
GHC20_05340	COG2376	Dihydroxyacetone kinase
GHC20_05345	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_05350	COG1879	ABC-type sugar transport system periplasmic component
GHC20_05355	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_05360	COG1129	ABC transporter
GHC20_05410	COG3328	transposase activity
GHC20_05455	COG1012	belongs to the aldehyde dehydrogenase family
GHC20_05480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GHC20_05495	COG0477	Major facilitator Superfamily
GHC20_05515	COG1522	sequence-specific DNA binding
GHC20_05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHC20_05530	COG1136	(ABC) transporter
GHC20_05530	COG4591	ABC-type transport system involved in lipoprotein release permease component
GHC20_05545	COG0848	biopolymer transport protein
GHC20_05575	COG3920	Histidine kinase
GHC20_05590	COG0784	Response regulator, receiver
GHC20_05620	COG0564	pseudouridine synthase activity
GHC20_05625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHC20_05645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GHC20_05655	COG0385	Bile acid
GHC20_05670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GHC20_05700	COG0848	biopolymer transport protein
GHC20_05710	COG0824	Thioesterase
GHC20_05755	COG0483	inositol monophosphate 1-phosphatase activity
GHC20_05770	COG1132	(ABC) transporter
GHC20_05805	COG1253	flavin adenine dinucleotide binding
GHC20_05810	COG1692	metallophosphoesterase
GHC20_05885	COG3328	transposase activity
GHC20_05900	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GHC20_05905	COG2258	MOSC domain
GHC20_05910	COG4783	chaperone-mediated protein folding
GHC20_05915	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GHC20_05945	COG3750	Belongs to the UPF0335 family
GHC20_05960	COG0469	pyruvate kinase activity
GHC20_05965	COG0457	Tetratricopeptide repeat
GHC20_05975	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GHC20_05980	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GHC20_06025	COG1329	Transcriptional regulator
GHC20_06045	COG0183	Belongs to the thiolase family
GHC20_06065	COG0142	geranyltranstransferase activity
GHC20_06075	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_06080	COG0738	Major facilitator superfamily
GHC20_06085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GHC20_06110	COG0411	ABC transporter
GHC20_06195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GHC20_06205	COG5425	PFAM Usg family protein
GHC20_06225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHC20_06225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GHC20_06240	COG2270	Major facilitator Superfamily
GHC20_06255	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GHC20_06260	COG1704	LemA family
GHC20_06275	COG1605	Chorismate mutase
GHC20_06275	COG0287	Prephenate dehydrogenase
GHC20_06280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GHC20_06290	COG0288	reversible hydration of carbon dioxide
GHC20_06330	COG0793	Belongs to the peptidase S41A family
GHC20_06350	COG0799	negative regulation of ribosome biogenesis
GHC20_06445	COG0739	heme binding
GHC20_06450	COG1376	ErfK ybiS ycfS ynhG family protein
GHC20_06470	COG2890	protein-(glutamine-N5) methyltransferase activity
GHC20_06485	COG0527	aspartate kinase activity
GHC20_06505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GHC20_06515	COG1040	competence protein
GHC20_06520	COG2226	methyltransferase
GHC20_06575	COG2264	protein methyltransferase activity
GHC20_06580	COG0697	spore germination
GHC20_06585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GHC20_06595	COG0004	ammonium transporteR
GHC20_06600	COG1946	Acyl-CoA thioesterase
GHC20_06605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHC20_06650	COG1953	Uracil, thiamine, allantoin
GHC20_06685	COG1280	lysine exporter protein (LysE YggA)
GHC20_06695	COG0508	dehydrogenase complex catalyzes the overall conversion of
GHC20_06705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GHC20_06725	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GHC20_06745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GHC20_06750	COG0552	protein localization to endoplasmic reticulum
GHC20_06775	COG0494	nUDIX hydrolase
GHC20_06790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHC20_06805	COG2194	sulfuric ester hydrolase activity
GHC20_06820	COG1802	Transcriptional regulator
GHC20_06825	COG0252	asparaginase activity
GHC20_06855	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHC20_06860	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GHC20_06865	COG2086	electron transfer activity
GHC20_06875	COG0720	synthase
GHC20_06880	COG0602	queuosine metabolic process
GHC20_06895	COG0300	oxidoreductase activity
GHC20_06910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHC20_06940	COG2226	methyltransferase
GHC20_06950	COG0287	Prephenate dehydrogenase
GHC20_06975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GHC20_06995	COG2884	Cell division ATP-binding protein ftsE
GHC20_07010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GHC20_07035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GHC20_07050	COG0789	Transcriptional regulator
GHC20_07055	COG2217	Heavy metal translocating P-type atpase
GHC20_07095	COG4536	flavin adenine dinucleotide binding
GHC20_07135	COG0523	cobalamin synthesis protein
GHC20_07140	COG1686	Belongs to the peptidase S11 family
GHC20_07145	COG1473	amidohydrolase
GHC20_07320	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_07350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GHC20_07365	COG4120	Belongs to the binding-protein-dependent transport system permease family
GHC20_07380	COG1475	DNA binding
GHC20_07385	COG1192	Involved in chromosome partitioning
GHC20_07405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GHC20_07410	COG1331	Highly conserved protein containing a thioredoxin domain
GHC20_07415	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GHC20_07445	COG0237	dephospho-CoA kinase activity
GHC20_07450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GHC20_07465	COG4395	Tim44
GHC20_07475	COG2840	Smr protein MutS2
GHC20_07480	COG1396	sequence-specific DNA binding
GHC20_07545	COG0745	RESPONSE REGULATOR receiver
GHC20_07550	COG2205	protein histidine kinase activity
GHC20_07560	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHC20_07560	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GHC20_07565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHC20_07575	COG2205	protein histidine kinase activity
GHC20_07580	COG3178	'Phosphotransferase
GHC20_07585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GHC20_07590	COG2887	Belongs to the helicase family. UvrD subfamily
GHC20_07595	COG1074	ATP-dependent DNA helicase activity
GHC20_07605	COG0285	dihydrofolate synthase activity
GHC20_07625	COG0133	tryptophan synthase activity
GHC20_07635	COG1434	Gram-negative-bacterium-type cell wall biogenesis
GHC20_07650	COG3135	benzoate transporter
GHC20_07710	COG3963	phosphatidate phosphatase activity
GHC20_07725	COG3386	PFAM SMP-30 Gluconolaconase
GHC20_07735	COG0606	chelatase, subunit chli
GHC20_07745	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GHC20_07750	COG2832	Protein of unknown function (DUF454)
GHC20_07755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GHC20_07760	COG0573	inorganic phosphate transmembrane transporter activity
GHC20_07775	COG0704	Plays a role in the regulation of phosphate uptake
GHC20_07780	COG0745	RESPONSE REGULATOR receiver
GHC20_07790	COG3773	Cell wall hydrolase
GHC20_07790	COG3409	Peptidoglycan-binding domain 1 protein
GHC20_07800	COG2309	aminopeptidase activity
GHC20_07805	COG0783	Belongs to the Dps family
GHC20_07815	COG0456	acetyltransferase
GHC20_07830	COG1702	phosphate starvation-inducible protein PhoH
GHC20_07850	COG1396	sequence-specific DNA binding
GHC20_07855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GHC20_07860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GHC20_07870	COG0195	Participates in both transcription termination and antitermination
GHC20_07870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GHC20_07930	COG0539	negative regulation of cytoplasmic translation
GHC20_07975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GHC20_07985	COG3617	BRO family, N-terminal domain
GHC20_08005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GHC20_08010	COG1960	acyl-CoA dehydrogenase activity
GHC20_08015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GHC20_08030	COG1024	Enoyl-CoA hydratase
GHC20_08050	COG4166	transmembrane transport
GHC20_08060	COG4174	ABC transporter (Permease)
GHC20_08065	COG4239	(ABC) transporter, permease
GHC20_08070	COG4172	Belongs to the ABC transporter superfamily
GHC20_08090	COG0592	DNA-directed DNA polymerase activity
GHC20_08105	COG1024	Enoyl-CoA hydratase
GHC20_08130	COG0791	NLP P60 protein
GHC20_08170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GHC20_08175	COG2813	Specifically methylates the guanine in position
GHC20_08185	COG3328	transposase activity
GHC20_08200	COG2855	membrane
GHC20_08215	COG2951	lytic endotransglycosylase activity
GHC20_08230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GHC20_08245	COG2816	NAD+ diphosphatase activity
GHC20_08250	COG0077	Prephenate dehydratase
GHC20_08250	COG1605	Chorismate mutase
GHC20_08260	COG3474	cytochrome
GHC20_08270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GHC20_08275	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GHC20_08280	COG1845	cytochrome c oxidase, subunit III
GHC20_08285	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GHC20_08305	COG1376	ErfK ybiS ycfS ynhG family protein
GHC20_08340	COG0489	protein tyrosine kinase activity
GHC20_08345	COG0346	lactoylglutathione lyase activity
GHC20_08350	COG3328	transposase activity
GHC20_08355	COG0033	Phosphoglucomutase
GHC20_08370	COG1073	alpha beta
GHC20_08375	COG1072	(Pantothenic acid kinase))
GHC20_08410	COG1272	protein, Hemolysin III
GHC20_08440	COG0670	Belongs to the BI1 family
GHC20_08450	COG4181	ATPase activity
GHC20_08460	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GHC20_08465	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GHC20_08470	COG3339	Conserved Protein
GHC20_08510	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GHC20_08520	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHC20_08525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GHC20_08535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GHC20_08580	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GHC20_08590	COG4208	sulfate ABC transporter
GHC20_08595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GHC20_08600	COG3459	Glycosyltransferase 36 associated
GHC20_08610	COG0384	phenazine biosynthesis protein PhzF
GHC20_08620	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_08625	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GHC20_08640	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHC20_08645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GHC20_08650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHC20_08650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GHC20_08665	COG0187	DNA topoisomerase II activity
GHC20_08670	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GHC20_08680	COG2153	protein acetylation
GHC20_08695	COG1643	Atp-dependent helicase
GHC20_08705	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GHC20_08715	COG1388	LysM domain
GHC20_08715	COG1376	ErfK ybiS ycfS ynhG family protein
GHC20_08720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GHC20_08730	COG0180	Tryptophanyl-tRNA synthetase
GHC20_08735	COG0728	peptidoglycan biosynthetic process
GHC20_08745	COG0281	malic enzyme
GHC20_08745	COG0280	phosphate acetyltransferase
GHC20_08750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GHC20_08765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GHC20_08770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GHC20_08770	COG0116	Belongs to the methyltransferase superfamily
GHC20_08785	COG0616	signal peptide processing
GHC20_08795	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GHC20_08800	COG1137	ATPase activity
GHC20_08805	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GHC20_08810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GHC20_08815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GHC20_08825	COG0071	Belongs to the small heat shock protein (HSP20) family
GHC20_08850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHC20_08855	COG2860	membrane
GHC20_08880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GHC20_08885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GHC20_08890	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GHC20_08900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GHC20_08900	COG1648	precorrin-2 dehydrogenase activity
GHC20_08910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GHC20_08915	COG0175	sulfate reduction
GHC20_08930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GHC20_08950	COG2197	response regulator
GHC20_08955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GHC20_08970	COG1218	3'(2'),5'-bisphosphate nucleotidase
GHC20_08985	COG2197	response regulator
GHC20_09005	COG1012	belongs to the aldehyde dehydrogenase family
GHC20_09025	COG5265	(ABC) transporter
GHC20_09030	COG1012	belongs to the aldehyde dehydrogenase family
GHC20_09035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GHC20_09040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GHC20_09045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GHC20_09070	COG0351	phosphomethylpyrimidine kinase
GHC20_09075	COG5001	Diguanylate cyclase
GHC20_09090	COG1174	glycine betaine transport
GHC20_09095	COG1125	glycine betaine transport
GHC20_09100	COG1174	glycine betaine transport
GHC20_09105	COG1732	Glycine betaine
GHC20_09115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GHC20_09130	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHC20_09130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GHC20_09155	COG1175	transmembrane transport
GHC20_09160	COG0395	ABC-type sugar transport system, permease component
GHC20_09165	COG3842	ATPase activity
GHC20_09170	COG4948	Mandelate Racemase Muconate Lactonizing
GHC20_09175	COG3254	rhamnose metabolic process
GHC20_09185	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_09195	COG4948	Mandelate Racemase Muconate Lactonizing
GHC20_09200	COG3153	acetyltransferase
GHC20_09205	COG4453	Protein conserved in bacteria
GHC20_09210	COG0582	viral genome integration into host DNA
GHC20_09360	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GHC20_09375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GHC20_09380	COG5328	Belongs to the UPF0262 family
GHC20_09415	COG3328	transposase activity
GHC20_09420	COG3012	SEC-C Motif Domain Protein
GHC20_09420	COG3318	Belongs to the UPF0149 family
GHC20_09430	COG0745	RESPONSE REGULATOR receiver
GHC20_09495	COG4191	Histidine kinase
GHC20_09500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHC20_09505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GHC20_09520	COG1309	transcriptional regulator
GHC20_09525	COG0494	nUDIX hydrolase
GHC20_09535	COG0493	'glutamate synthase
GHC20_09565	COG0318	PFAM AMP-dependent synthetase and ligase
GHC20_09595	COG2326	polyphosphate kinase activity
GHC20_09600	COG5002	protein histidine kinase activity
GHC20_09610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHC20_09620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GHC20_09640	COG0717	Belongs to the dCTP deaminase family
GHC20_09660	COG0534	Mate efflux family protein
GHC20_09690	COG2198	Histidine kinase
GHC20_09690	COG0784	Response regulator, receiver
GHC20_09690	COG2205	protein histidine kinase activity
GHC20_09700	COG0156	8-amino-7-oxononanoate synthase activity
GHC20_09725	COG0583	DNA-binding transcription factor activity
GHC20_09730	COG1380	Effector of murein hydrolase LrgA
GHC20_09735	COG1346	cytolysis
GHC20_09765	COG0019	diaminopimelate decarboxylase activity
GHC20_09780	COG0534	Mate efflux family protein
GHC20_09805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GHC20_09810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GHC20_09815	COG3257	ureidoglycine aminohydrolase activity
GHC20_09820	COG3648	Uricase
GHC20_09820	COG3195	allantoin biosynthetic process
GHC20_09830	COG2080	2 iron, 2 sulfur cluster binding
GHC20_09835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GHC20_09845	COG0583	DNA-binding transcription factor activity
GHC20_09855	COG0402	S-adenosylhomocysteine deaminase activity
GHC20_09915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GHC20_09915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GHC20_09925	COG2169	Transcriptional regulator
GHC20_09925	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GHC20_09930	COG1393	Belongs to the ArsC family
GHC20_09940	COG0477	Major facilitator Superfamily
GHC20_09945	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GHC20_09970	COG3773	Cell wall hydrolase
GHC20_10015	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GHC20_10030	COG1960	acyl-CoA dehydrogenase activity
GHC20_10050	COG0009	L-threonylcarbamoyladenylate synthase
GHC20_10055	COG0751	glycine-tRNA ligase activity
GHC20_10070	COG0142	geranyltranstransferase activity
GHC20_10135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GHC20_10145	COG1278	Cold shock
GHC20_10175	COG0123	including yeast histone deacetylase and acetoin utilization protein
GHC20_10180	COG1722	exodeoxyribonuclease VII activity
GHC20_10200	COG1741	Belongs to the pirin family
GHC20_10210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GHC20_10220	COG3328	transposase activity
GHC20_10240	COG5265	(ABC) transporter
GHC20_10250	COG1183	phosphatidylcholine synthase activity
GHC20_10255	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_10260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GHC20_10275	COG0305	Participates in initiation and elongation during chromosome replication
GHC20_10280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GHC20_10305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GHC20_10325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GHC20_10330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GHC20_10335	COG1561	YicC-like family, N-terminal region
GHC20_10345	COG0312	modulator of DNA gyrase
GHC20_10355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GHC20_10360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GHC20_10410	COG0678	peroxiredoxin activity
GHC20_10410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GHC20_10420	COG1678	Uncharacterized ACR, COG1678
GHC20_10430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GHC20_10435	COG0612	Peptidase, M16
GHC20_10450	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GHC20_10460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GHC20_10480	COG1194	a g-specific adenine glycosylase
GHC20_10500	COG1196	nuclear chromosome segregation
GHC20_10515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GHC20_10515	COG0574	Belongs to the PEP-utilizing enzyme family
GHC20_10540	COG1268	BioY protein
GHC20_10550	COG2351	hydroxyisourate hydrolase activity
GHC20_10565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHC20_10610	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
GHC20_10610	COG0662	Cupin 2, conserved barrel domain protein
GHC20_10615	COG2942	2-epimerase
GHC20_10620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GHC20_10620	COG0438	transferase activity, transferring glycosyl groups
GHC20_10625	COG1091	dTDP-4-dehydrorhamnose reductase activity
GHC20_10630	COG1129	ABC transporter
GHC20_10635	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_10640	COG1879	ABC-type sugar transport system periplasmic component
GHC20_10650	COG0673	inositol 2-dehydrogenase activity
GHC20_10660	COG1070	Carbohydrate kinase
GHC20_10700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHC20_10710	COG2336	PFAM SpoVT AbrB
GHC20_10720	COG2186	Transcriptional regulator
GHC20_10725	COG2807	transmembrane transport
GHC20_10740	COG0433	COG0433 Predicted ATPase
GHC20_10745	COG1376	ErfK ybiS ycfS ynhG family protein
GHC20_10760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GHC20_10775	COG4957	zinc ion binding
GHC20_10785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GHC20_10800	COG2166	iron-sulfur cluster assembly
GHC20_10810	COG2205	protein histidine kinase activity
GHC20_10840	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GHC20_10855	COG4695	Portal protein
GHC20_10940	COG0745	RESPONSE REGULATOR receiver
GHC20_10945	COG2205	protein histidine kinase activity
GHC20_10955	COG4235	cytochrome complex assembly
GHC20_10965	COG1138	Cytochrome C-type biogenesis protein
GHC20_10970	COG3088	subunit of a heme lyase
GHC20_10975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GHC20_10990	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GHC20_11000	COG2202	Pas domain
GHC20_11000	COG2205	protein histidine kinase activity
GHC20_11005	COG0308	aminopeptidase N
GHC20_11020	COG1573	uracil-dna glycosylase
GHC20_11035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GHC20_11040	COG0625	glutathione transferase activity
GHC20_11075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GHC20_11110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GHC20_11110	COG3743	rRNA binding
GHC20_11115	COG0741	lytic transglycosylase activity
GHC20_11155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GHC20_11160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GHC20_11165	COG2223	nitrite transmembrane transporter activity
GHC20_11170	COG2207	Transcriptional regulator
GHC20_11185	COG0681	Belongs to the peptidase S26 family
GHC20_11210	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GHC20_11220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHC20_11240	COG0494	nUDIX hydrolase
GHC20_11270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GHC20_11280	COG0739	heme binding
GHC20_11290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GHC20_11295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHC20_11300	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
GHC20_11330	COG0488	(ABC) transporter
GHC20_11350	COG0314	molybdopterin synthase activity
GHC20_11355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GHC20_11360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GHC20_11395	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GHC20_11405	COG0243	molybdopterin cofactor binding
GHC20_11415	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GHC20_11425	COG1192	Involved in chromosome partitioning
GHC20_11435	COG1414	Transcriptional regulator
GHC20_11445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHC20_11450	COG1957	nucleoside hydrolase
GHC20_11470	COG1744	ABC transporter substrate-binding protein PnrA-like
GHC20_11485	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_11490	COG1535	isochorismatase
GHC20_11490	COG3433	isochorismatase activity
GHC20_11495	COG1021	2,3-dihydroxybenzoate-AMP ligase
GHC20_11500	COG1169	isochorismate synthase
GHC20_11505	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GHC20_11505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GHC20_11510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GHC20_11530	COG4944	Protein of unknown function (DUF1109)
GHC20_11595	COG4191	Histidine kinase
GHC20_11600	COG4566	intracellular signal transduction
GHC20_11880	COG0592	DNA-directed DNA polymerase activity
GHC20_11925	COG0483	inositol monophosphate 1-phosphatase activity
GHC20_11935	COG2188	Transcriptional regulator
GHC20_11980	COG1063	alcohol dehydrogenase
GHC20_11985	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_11995	COG1012	belongs to the aldehyde dehydrogenase family
GHC20_12015	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GHC20_12025	COG1129	ABC transporter
GHC20_12030	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_12035	COG0277	FAD linked oxidase domain protein
GHC20_12075	COG1126	abc transporter atp-binding protein
GHC20_12085	COG0765	amino acid transport
GHC20_12110	COG0583	DNA-binding transcription factor activity
GHC20_12135	COG1609	Transcriptional regulator
GHC20_12145	COG1653	transport
GHC20_12150	COG1175	transmembrane transport
GHC20_12155	COG0395	ABC-type sugar transport system, permease component
GHC20_12165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHC20_12175	COG3842	ATPase activity
GHC20_12180	COG3328	transposase activity
GHC20_12200	COG4214	carbohydrate transport
GHC20_12210	COG4213	ABC transporter substrate-binding protein
GHC20_12220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GHC20_12235	COG1360	Flagellar Motor Protein
GHC20_12285	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GHC20_12295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GHC20_12330	COG0735	belongs to the Fur family
GHC20_12335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GHC20_12345	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
GHC20_12350	COG0523	cobalamin synthesis protein
GHC20_12355	COG1959	2 iron, 2 sulfur cluster binding
GHC20_12360	COG2971	BadF BadG BcrA BcrD
GHC20_12440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GHC20_12450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GHC20_12455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GHC20_12460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GHC20_12470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GHC20_12495	COG0778	Nitroreductase
GHC20_12530	COG1902	pentaerythritol trinitrate reductase activity
GHC20_12530	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHC20_12540	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GHC20_12550	COG4176	ABC-type proline glycine betaine transport system permease component
GHC20_12555	COG4175	Glycine betaine
GHC20_12555	COG0517	IMP dehydrogenase activity
GHC20_12560	COG1902	pentaerythritol trinitrate reductase activity
GHC20_12560	COG0446	pyridine nucleotide-disulphide oxidoreductase
GHC20_12565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GHC20_12590	COG4948	Mandelate Racemase Muconate Lactonizing
GHC20_12610	COG1126	abc transporter atp-binding protein
GHC20_12615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHC20_12620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHC20_12620	COG0723	plastoquinol--plastocyanin reductase activity
GHC20_12625	COG0765	amino acid transport
GHC20_12630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GHC20_12635	COG1473	amidohydrolase
GHC20_12675	COG1132	(ABC) transporter
GHC20_12700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GHC20_12730	COG2827	Endonuclease containing a URI domain
GHC20_12745	COG0242	peptide deformylase activity
GHC20_12830	COG0251	oxidation-reduction process
GHC20_12845	COG2814	Major facilitator Superfamily
GHC20_12850	COG1802	Transcriptional regulator
GHC20_12880	COG0444	Belongs to the ABC transporter superfamily
GHC20_12885	COG4608	Belongs to the ABC transporter superfamily
GHC20_12890	COG0154	amidase activity
GHC20_12895	COG2176	DNA-directed DNA polymerase activity
GHC20_12900	COG0579	oxidoreductase
GHC20_12905	COG3706	GGDEF domain
GHC20_12945	COG1879	ABC-type sugar transport system periplasmic component
GHC20_12950	COG1129	ABC transporter
GHC20_12960	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_12965	COG0251	oxidation-reduction process
GHC20_12975	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GHC20_12980	COG0400	carboxylic ester hydrolase activity
GHC20_12990	COG0523	cobalamin synthesis protein
GHC20_13000	COG1846	Transcriptional regulator
GHC20_13005	COG1609	Transcriptional regulator
GHC20_13015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GHC20_13020	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_13025	COG5001	Diguanylate cyclase
GHC20_13045	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GHC20_13050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GHC20_13055	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GHC20_13095	COG2011	ABC-type metal ion transport system permease component
GHC20_13120	COG0559	Belongs to the binding-protein-dependent transport system permease family
GHC20_13125	COG0410	ABC transporter
GHC20_13155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHC20_13165	COG0028	Belongs to the TPP enzyme family
GHC20_13170	COG2186	Transcriptional regulator
GHC20_13175	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_13190	COG0129	dihydroxy-acid dehydratase activity
GHC20_13195	COG3734	2-keto-3-deoxy-galactonokinase
GHC20_13200	COG0800	Aldolase
GHC20_13205	COG4213	ABC transporter substrate-binding protein
GHC20_13215	COG4214	carbohydrate transport
GHC20_13250	COG0402	S-adenosylhomocysteine deaminase activity
GHC20_13280	COG1522	sequence-specific DNA binding
GHC20_13285	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GHC20_13290	COG1304	FMN binding
GHC20_13295	COG0243	molybdopterin cofactor binding
GHC20_13310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHC20_13330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GHC20_13345	COG1012	belongs to the aldehyde dehydrogenase family
GHC20_13350	COG5383	Protein conserved in bacteria
GHC20_13360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHC20_13365	COG2183	response to ionizing radiation
GHC20_13370	COG0640	Transcriptional regulator
GHC20_13375	COG1902	pentaerythritol trinitrate reductase activity
GHC20_13450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GHC20_13455	COG1846	Transcriptional regulator
GHC20_13460	COG1764	response to oxidative stress
GHC20_13495	COG2239	Acts as a magnesium transporter
GHC20_13530	COG1349	DNA-binding transcription factor activity
GHC20_13565	COG1129	ABC transporter
GHC20_13570	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_13575	COG1879	ABC-type sugar transport system periplasmic component
GHC20_13580	COG1349	DNA-binding transcription factor activity
GHC20_13585	COG0546	phosphoglycolate phosphatase activity
GHC20_13585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GHC20_13590	COG0277	FAD linked oxidase domain protein
GHC20_13600	COG1088	dTDP-glucose 4,6-dehydratase activity
GHC20_13645	COG4585	Histidine kinase
GHC20_13660	COG1120	ATPase activity
GHC20_13665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHC20_13670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHC20_13675	COG4592	Periplasmic binding protein
GHC20_13690	COG2819	hydrolase of the alpha beta superfamily
GHC20_13735	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GHC20_13790	COG1396	sequence-specific DNA binding
GHC20_13825	COG1201	RNA secondary structure unwinding
GHC20_13840	COG0730	response to heat
GHC20_13850	COG0789	Transcriptional regulator
GHC20_13855	COG1993	acr, cog1993
GHC20_13875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GHC20_13890	COG0747	negative chemotaxis
GHC20_13895	COG0601	transmembrane transport
GHC20_13900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHC20_13920	COG0583	DNA-binding transcription factor activity
GHC20_13930	COG1960	acyl-CoA dehydrogenase activity
GHC20_13935	COG0183	Belongs to the thiolase family
GHC20_13940	COG1024	Enoyl-CoA hydratase
GHC20_13940	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHC20_13965	COG0288	reversible hydration of carbon dioxide
GHC20_13975	COG0747	negative chemotaxis
GHC20_13985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHC20_13990	COG0444	Belongs to the ABC transporter superfamily
GHC20_14010	COG0129	dihydroxy-acid dehydratase activity
GHC20_14015	COG0363	glucosamine-6-phosphate deaminase activity
GHC20_14025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GHC20_14065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHC20_14075	COG0174	glutamine synthetase
GHC20_14090	COG0583	DNA-binding transcription factor activity
GHC20_14110	COG1846	Transcriptional regulator
GHC20_14140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHC20_14145	COG1120	ATPase activity
GHC20_14160	COG0395	ABC-type sugar transport system, permease component
GHC20_14185	COG1737	Transcriptional regulator
GHC20_14210	COG4176	ABC-type proline glycine betaine transport system permease component
GHC20_14220	COG2176	DNA-directed DNA polymerase activity
GHC20_14275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GHC20_14280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GHC20_14295	COG3706	GGDEF domain
GHC20_14295	COG0745	RESPONSE REGULATOR receiver
GHC20_14320	COG0557	exoribonuclease II activity
GHC20_14325	COG1754	DNA topoisomerase type I activity
GHC20_14325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GHC20_14330	COG0758	DNA mediated transformation
GHC20_14340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GHC20_14350	COG1960	acyl-CoA dehydrogenase activity
GHC20_14385	COG0187	DNA topoisomerase II activity
GHC20_14390	COG0697	spore germination
GHC20_14440	COG3328	transposase activity
GHC20_14495	COG0785	Cytochrome C biogenesis protein
GHC20_14515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GHC20_14520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GHC20_14525	COG0346	lactoylglutathione lyase activity
GHC20_14550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GHC20_14555	COG1183	phosphatidylcholine synthase activity
GHC20_14565	COG1129	ABC transporter
GHC20_14610	COG1959	2 iron, 2 sulfur cluster binding
GHC20_14615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GHC20_14645	COG0601	transmembrane transport
GHC20_14650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GHC20_14655	COG4172	Belongs to the ABC transporter superfamily
GHC20_14660	COG3145	DNA-N1-methyladenine dioxygenase activity
GHC20_14665	COG0477	Major facilitator Superfamily
GHC20_14700	COG0022	dehydrogenase e1 component
GHC20_14720	COG0673	inositol 2-dehydrogenase activity
GHC20_14725	COG0395	ABC-type sugar transport system, permease component
GHC20_14740	COG2971	BadF BadG BcrA BcrD
GHC20_14745	COG2188	Transcriptional regulator
GHC20_14755	COG1294	oxidase, subunit
GHC20_14760	COG1271	oxidase subunit
GHC20_14765	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GHC20_14770	COG4988	ABC transporter
GHC20_14785	COG2212	antiporter activity
GHC20_14790	COG1863	multisubunit Na H antiporter MnhE subunit
GHC20_14795	COG0651	ATP synthesis coupled electron transport
GHC20_14800	COG1006	Multisubunit Na H antiporter MnhC subunit
GHC20_14805	COG2111	Na H antiporter
GHC20_14805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GHC20_14820	COG0521	Mo-molybdopterin cofactor biosynthetic process
GHC20_14835	COG0156	8-amino-7-oxononanoate synthase activity
GHC20_14845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GHC20_14850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GHC20_14865	COG1115	amino acid carrier protein
GHC20_14880	COG1252	NADH dehydrogenase
GHC20_14920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GHC20_14930	COG0842	Transport permease protein
GHC20_14935	COG1131	(ABC) transporter
GHC20_14970	COG0640	Transcriptional regulator
GHC20_14975	COG2354	Protein conserved in bacteria
GHC20_14980	COG0242	peptide deformylase activity
GHC20_14985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GHC20_14995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GHC20_15005	COG0183	Belongs to the thiolase family
GHC20_15010	COG1960	acyl-CoA dehydrogenase activity
GHC20_15015	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GHC20_15020	COG0583	DNA-binding transcription factor activity
GHC20_15025	COG2814	Major facilitator Superfamily
GHC20_15035	COG2233	PERMEase
GHC20_15055	COG4607	ABC-type enterochelin transport system periplasmic component
GHC20_15060	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GHC20_15065	COG4605	iron ion homeostasis
GHC20_15070	COG4604	ABC transporter, ATP-binding protein
GHC20_15085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHC20_15090	COG0765	amino acid transport
GHC20_15095	COG1126	abc transporter atp-binding protein
GHC20_15100	COG0248	Ppx GppA phosphatase
GHC20_15110	COG0477	Major facilitator Superfamily
GHC20_15155	COG1840	ABC-type Fe3 transport system, periplasmic component
GHC20_15160	COG3842	ATPase activity
GHC20_15165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHC20_15175	COG2132	Multicopper oxidase
GHC20_15185	COG0477	Major facilitator Superfamily
GHC20_15190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GHC20_15195	COG0450	alkyl hydroperoxide reductase
GHC20_15210	COG0673	inositol 2-dehydrogenase activity
GHC20_15220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GHC20_15225	COG3962	Belongs to the TPP enzyme family
GHC20_15235	COG3718	enzyme involved in inositol metabolism
GHC20_15255	COG1840	ABC-type Fe3 transport system, periplasmic component
GHC20_15265	COG1522	sequence-specific DNA binding
GHC20_15285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GHC20_15355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GHC20_15360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GHC20_15390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GHC20_15400	COG1414	Transcriptional regulator
GHC20_15415	COG0583	DNA-binding transcription factor activity
GHC20_15420	COG2267	carboxylic ester hydrolase activity
GHC20_15425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GHC20_15430	COG3485	protocatechuate 3,4-dioxygenase
GHC20_15435	COG3485	protocatechuate 3,4-dioxygenase
GHC20_15440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GHC20_15445	COG0683	leucine binding
GHC20_15460	COG0411	ABC transporter
GHC20_15465	COG3842	ATPase activity
GHC20_15490	COG0395	ABC-type sugar transport system, permease component
GHC20_15500	COG3273	potassium ion transport
GHC20_15500	COG0471	metal ion transport
GHC20_15510	COG2252	PERMEase
GHC20_15535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GHC20_15545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GHC20_15560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GHC20_15565	COG4310	Domain of unknown function (DUF2172)
GHC20_15570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GHC20_15585	COG0438	transferase activity, transferring glycosyl groups
GHC20_15605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GHC20_15625	COG0110	maltose O-acetyltransferase activity
GHC20_15630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GHC20_15650	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GHC20_15655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHC20_15670	COG2197	response regulator
GHC20_15690	COG1940	carbohydrate kinase activity
GHC20_15690	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GHC20_15695	COG2186	Transcriptional regulator
GHC20_15715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHC20_15745	COG2124	cytochrome p450
GHC20_15750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GHC20_15755	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
GHC20_15820	COG5314	conjugation
GHC20_15840	COG3328	transposase activity
GHC20_15860	COG0582	viral genome integration into host DNA
GHC20_15880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GHC20_15880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GHC20_15895	COG0583	DNA-binding transcription factor activity
GHC20_15900	COG3258	Cytochrome c
GHC20_15915	COG3191	aminopeptidase activity
GHC20_15920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GHC20_15935	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GHC20_15955	COG0531	amino acid
GHC20_15960	COG0076	glutamate decarboxylase activity
GHC20_15995	COG1177	transmembrane transport
GHC20_16000	COG1176	ABC-type spermidine putrescine transport system, permease component I
GHC20_16005	COG3842	ATPase activity
GHC20_16030	COG2894	cell division
GHC20_16055	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GHC20_16060	COG2814	Major facilitator Superfamily
GHC20_16070	COG0673	inositol 2-dehydrogenase activity
GHC20_16095	COG1653	transport
GHC20_16100	COG1609	Transcriptional regulator
GHC20_16110	COG2223	nitrite transmembrane transporter activity
GHC20_16115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GHC20_16120	COG1140	nitrate reductase beta subunit
GHC20_16125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GHC20_16130	COG2181	nitrate reductase activity
GHC20_16135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GHC20_16145	COG0163	prenyltransferase activity
GHC20_16175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GHC20_16200	COG1477	protein flavinylation
GHC20_16240	COG4178	(ABC) transporter
GHC20_16250	COG5654	RES domain protein
GHC20_16285	COG2151	metal-sulfur cluster biosynthetic enzyme
GHC20_16310	COG0714	Associated with various cellular activities
GHC20_16315	COG3256	nitric oxide reductase
GHC20_16330	COG1845	cytochrome c oxidase, subunit III
GHC20_16345	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GHC20_16350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GHC20_16370	COG1477	protein flavinylation
GHC20_16390	COG0745	RESPONSE REGULATOR receiver
GHC20_16415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHC20_16420	COG1250	3-hydroxyacyl-CoA dehydrogenase
GHC20_16425	COG1024	Enoyl-CoA hydratase
GHC20_16435	COG1960	acyl-CoA dehydrogenase activity
GHC20_16440	COG2814	Major facilitator Superfamily
GHC20_16460	COG1519	Transferase
GHC20_16480	COG0312	modulator of DNA gyrase
GHC20_16485	COG0475	glutathione-regulated potassium exporter activity
GHC20_16485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GHC20_16495	COG0612	Peptidase, M16
GHC20_16500	COG0612	Peptidase, M16
GHC20_16505	COG0742	ribosomal rna small subunit methyltransferase
GHC20_16515	COG0590	tRNA wobble adenosine to inosine editing
GHC20_16535	COG0196	riboflavin kinase activity
GHC20_16560	COG0114	fumarate hydratase activity
GHC20_16565	COG2259	Doxx family
GHC20_16595	COG2818	Glycosylase
GHC20_16600	COG1376	ErfK ybiS ycfS ynhG family protein
GHC20_16600	COG1388	LysM domain
GHC20_16605	COG0656	L-ascorbic acid biosynthetic process
GHC20_16615	COG0247	lactate metabolic process
GHC20_16625	COG0277	FAD linked oxidase domain protein
GHC20_16630	COG0583	DNA-binding transcription factor activity
GHC20_16635	COG2186	Transcriptional regulator
GHC20_16695	COG3038	cytochrome b561
GHC20_16710	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GHC20_16720	COG0583	DNA-binding transcription factor activity
GHC20_16725	COG4952	isomerase
GHC20_16730	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_16730	COG3347	Dehydrogenase
GHC20_16735	COG1349	DNA-binding transcription factor activity
GHC20_16740	COG1879	ABC-type sugar transport system periplasmic component
GHC20_16745	COG1129	ABC transporter
GHC20_16750	COG1172	Belongs to the binding-protein-dependent transport system permease family
GHC20_16760	COG3254	rhamnose metabolic process
GHC20_16780	COG1338	Plays a role in the flagellum-specific transport system
GHC20_16800	COG1706	bacterial-type flagellum-dependent cell motility
GHC20_16810	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
GHC20_16815	COG4786	Flagellar basal body rod
GHC20_16820	COG1677	Flagellar hook-basal body complex protein FliE
GHC20_16825	COG1558	bacterial-type flagellum-dependent cell motility
GHC20_16830	COG1815	bacterial-type flagellum-dependent cell motility
GHC20_16835	COG2084	Dehydrogenase
GHC20_16840	COG3395	kinase activity
GHC20_16845	COG3622	Belongs to the hyi family
GHC20_16850	COG1349	DNA-binding transcription factor activity
GHC20_16855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GHC20_16860	COG0235	Class ii aldolase
GHC20_16865	COG2271	Major facilitator Superfamily
GHC20_16870	COG2963	transposase activity
GHC20_16890	COG0463	Glycosyl transferase, family 2
GHC20_16900	COG0671	phosphoesterase, PA-phosphatase related
GHC20_16910	COG1157	protein secretion by the type III secretion system
GHC20_16915	COG4786	Flagellar basal body rod
GHC20_16925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GHC20_16940	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GHC20_16945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GHC20_16950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GHC20_16965	COG1309	transcriptional regulator
GHC20_17010	COG0477	Major facilitator Superfamily
GHC20_17035	COG1028	Short-chain dehydrogenase reductase Sdr
GHC20_17070	COG0179	Fumarylacetoacetate (FAA) hydrolase
GHC20_17120	COG0583	DNA-binding transcription factor activity
GHC20_17125	COG0154	amidase activity
GHC20_17140	COG0673	inositol 2-dehydrogenase activity
GHC20_17175	COG3206	protein involved in exopolysaccharide biosynthesis
GHC20_17175	COG0489	protein tyrosine kinase activity
GHC20_17185	COG0154	amidase activity
GHC20_17190	COG0583	DNA-binding transcription factor activity
GHC20_17200	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GHC20_17215	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GHC20_17220	COG4149	molybdate abc transporter
GHC20_17225	COG0725	ABC transporter, periplasmic molybdate-binding protein
GHC20_17240	COG0800	Aldolase
GHC20_17245	COG3108	Peptidase M15
GHC20_17250	COG2204	response regulator
GHC20_17270	COG5310	Homospermidine synthase
GHC20_17285	COG0330	HflC and HflK could
GHC20_17305	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GHC20_17310	COG2951	lytic endotransglycosylase activity
GHC20_17360	COG2948	multi-organism process
GHC20_17380	COG1113	amino acid transport
GHC20_17390	COG0067	glutamate synthase
GHC20_17390	COG0069	glutamate synthase activity
GHC20_17390	COG0070	glutamate synthase
GHC20_17400	COG0071	Belongs to the small heat shock protein (HSP20) family
GHC20_17410	COG0765	amino acid transport
GHC20_17415	COG0765	amino acid transport
GHC20_17425	COG1960	acyl-CoA dehydrogenase activity
GHC20_17430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GHC20_17445	COG2188	Transcriptional regulator
GHC20_17450	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GHC20_17455	COG1653	transport
GHC20_17460	COG3833	ABC-type maltose transport systems, permease component
GHC20_17465	COG1175	transmembrane transport
GHC20_17470	COG3842	ATPase activity
GHC20_17485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GHC20_17520	COG0559	Belongs to the binding-protein-dependent transport system permease family
GHC20_17530	COG0411	ABC transporter
GHC20_17535	COG0410	ABC transporter
GHC20_17545	COG0635	Involved in the biosynthesis of porphyrin-containing compound