locus-tag class description DM57_05080 ENOG4108TGY Glutathione S-transferase DM57_05110 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DM57_05165 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DM57_05170 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DM57_05175 ENOG4107YZX Universal stress protein DM57_05215 ENOG4105D7W serine acetyltransferase DM57_05225 ENOG4105EUJ GTP cyclohydrolase i DM57_05245 ENOG4107QNJ CoA-transferase subunit B DM57_05250 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase DM57_05255 ENOG4105F2Z 3-oxoadipate enol-lactonase DM57_05260 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DM57_05265 ENOG4105D2S major facilitator superfamily DM57_05315 ENOG4105EMN RNA polymerase sigma factor DM57_05320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DM57_05345 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS DM57_05350 ENOG4105CSH Transporter DM57_05355 ENOG4105CQZ Histidine kinase DM57_05360 ENOG4105CQZ Histidine kinase DM57_05365 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_05390 ENOG4105HSS phospholipase C DM57_05455 ENOG4105BZU Histidine kinase DM57_05465 ENOG4108J2P Alpha beta hydrolase fold DM57_05485 ENOG4105JQN Transcriptional regulator DM57_05520 ENOG4105D9N nucleoside DM57_05525 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) DM57_05545 ENOG4105KG3 cytidine deaminase DM57_05550 ENOG4105K3G Periplasmic Protein DM57_05565 ENOG4107QYA phosphate DM57_05570 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class DM57_05580 ENOG41081R2 Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DM57_05595 ENOG4107WCG it plays a direct role in the translocation of protons across the membrane (By similarity) DM57_05605 ENOG4108Q71 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) DM57_05635 ENOG4105C8Q Methyl-accepting chemotaxis DM57_05640 ENOG4105BZU Histidine kinase DM57_05645 ENOG4105CMI transporter DM57_05650 ENOG4105CJ1 ABC, transporter DM57_05655 ENOG4105D0S secretion protein (HlyD DM57_05660 ENOG4105D0S secretion protein (HlyD DM57_05665 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DM57_05675 ENOG4107YZX Universal stress protein DM57_05690 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DM57_05700 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DM57_05705 ENOG4105C8Q Methyl-accepting chemotaxis DM57_05765 ENOG4105DS0 Transcriptional regulator, Crp Fnr family DM57_05770 ENOG4105CHR reductase DM57_05780 ENOG4105CY0 Metallo-Beta-Lactamase DM57_05810 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DM57_05830 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) DM57_05840 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DM57_05845 ENOG4108Z9W Outer membrane porin DM57_05895 ENOG4108KDI dmso reductase anchor subunit DM57_05900 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein DM57_05905 ENOG4105DB1 molybdopterin oxidoreductase DM57_05925 ENOG4105E2B Taurine dioxygenase DM57_05930 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DM57_05940 ENOG41061ZR Transcriptional regulator DM57_05950 ENOG4108Z9W Outer membrane porin DM57_05955 ENOG4107Y70 Heat shock protein DM57_05965 ENOG4105CJW magnesium transporter DM57_06005 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase DM57_06035 ENOG4107R0V Pyruvate dehydrogenase DM57_06040 ENOG4105CPP Dehydrogenase, E1 component DM57_06045 ENOG4107QSN dihydrolipoamide acetyltransferase DM57_06050 ENOG4107QN2 dihydrolipoyl dehydrogenase DM57_06065 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) DM57_06090 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DM57_06100 ENOG4105E33 succinate dehydrogenase DM57_06105 ENOG4105DJ4 phosphatidylserine decarboxylase DM57_06115 ENOG4108JJ7 ABC transporter DM57_06125 ENOG4105CHR reductase DM57_06130 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DM57_06135 ENOG4105XA0 heptosyltransferase ii DM57_06160 ENOG4108JUA Transcriptional regulator DM57_06165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_06180 ENOG4105BZU Histidine kinase DM57_06190 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DM57_06200 ENOG4107JEE Short-chain dehydrogenase reductase Sdr DM57_06220 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DM57_06240 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DM57_06255 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DM57_06260 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DM57_06265 ENOG4105CKK Glycosyl transferase, family 2 DM57_06340 ENOG4105C1J atp-dependent rna helicase DM57_06355 ENOG4105CH2 amidohydrolase DM57_06360 ENOG4106KR7 LysR family Transcriptional regulator DM57_06385 ENOG4107RP9 extracellular solute-binding protein, family 3 DM57_06390 ENOG4105MWK D-amino acid dehydrogenase, small subunit DM57_06400 ENOG410904N short-chain dehydrogenase reductase DM57_06420 ENOG4105CWX Alpha-1,2-mannosidase DM57_06435 ENOG4105EFA 4-hydroxyphenylacetate DM57_06440 ENOG4105CAQ asparagine synthetase DM57_06445 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DM57_06455 ENOG4105JQN Transcriptional regulator DM57_06495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_06500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_06535 ENOG4105CS6 Rhs element vgr protein DM57_06570 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF DM57_06620 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DM57_06625 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DM57_06630 ENOG4105E7W lamb ycsf family protein DM57_06660 ENOG4105C8Q Methyl-accepting chemotaxis DM57_06670 ENOG4108JU7 Transcriptional regulator DM57_06675 ENOG4105CR4 methylisocitrate lyase DM57_06680 ENOG4105BZN citrate synthase DM57_06685 ENOG4108I0Z Aconitate hydratase DM57_06690 ENOG4105C7F AcnD-accessory protein PrpF DM57_06715 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E DM57_06720 ENOG4105C8Q Methyl-accepting chemotaxis DM57_06745 ENOG4105KT7 mgtC SapB transporter DM57_06770 ENOG4105C59 p-type ATPase DM57_06805 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DM57_06815 ENOG4105FE1 phytoene synthase DM57_06825 ENOG4105HEI LysR family (Transcriptional regulator DM57_06835 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DM57_06840 ENOG4105C4M (Ubiquinol oxidase) subunit I DM57_06845 ENOG4105C5W Aldolase DM57_06860 ENOG4105EN6 Membrane DM57_06865 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) DM57_06875 ENOG4105EHG Permease protein DM57_06880 ENOG4107R4I Periplasmic binding protein DM57_06885 ENOG4106QJH hemin transport protein DM57_06900 ENOG4105ETT transcriptional Regulator, LysR family DM57_06910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DM57_06915 ENOG4107QKW extracellular solute-binding protein family 1 DM57_06930 ENOG4108Z9W Outer membrane porin DM57_06940 ENOG4108YZG isomerase DM57_06945 ENOG4105C2J ABC transporter DM57_06950 ENOG4105CNN ABC, transporter DM57_06955 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DM57_06960 ENOG4105CHR reductase DM57_06965 ENOG4105CPQ Dehydrogenase DM57_06970 ENOG4105CMT Dihydroxyacetone kinase DM57_07020 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DM57_07025 ENOG4108UQY Iron-storage protein DM57_07035 ENOG4108TEB UPF0114 protein DM57_07055 ENOG4107QN1 sodium solute DM57_07065 ENOG4105DQ6 Transposase DM57_07075 ENOG4108JU3 Alkyl hydroperoxide reductase DM57_07080 ENOG4105D3R alkyl hydroperoxide reductase DM57_07090 ENOG41069NU Nitroreductase DM57_07160 ENOG4105DTI Phosphonopyruvate decarboxylase DM57_07210 ENOG4108YH7 hemolysin DM57_07215 ENOG4108QZZ filamentous hemagglutinin DM57_07220 ENOG4107QM5 aconitate hydratase DM57_07225 ENOG4105DXD 2-methylcitrate dehydratase DM57_07245 ENOG4105FDP GntR family transcriptional regulator DM57_07250 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) DM57_07260 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) DM57_07265 ENOG4105E33 succinate dehydrogenase DM57_07270 ENOG41060IS Flavinator of succinate dehydrogenase DM57_07275 ENOG4105BZN citrate synthase DM57_07310 ENOG41072TH Protein of unknown function (DUF1479) DM57_07315 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DM57_07320 ENOG4108YXU transcriptional regulator AsnC family DM57_07330 ENOG4105CPU Monooxygenase DM57_07350 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DM57_07360 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DM57_07375 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DM57_07380 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DM57_07395 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) DM57_07400 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DM57_07415 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DM57_07420 ENOG4105C28 cystathionine DM57_07430 ENOG4107TXM Nad-dependent epimerase dehydratase DM57_07435 ENOG4105C0K Gdp-mannose 4,6-dehydratase DM57_07440 ENOG4105EXC Acyl-transferase DM57_07450 ENOG4108MX3 Polysaccharide Biosynthesis Protein DM57_07455 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DM57_07470 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DM57_07480 ENOG4105EXC Acyl-transferase DM57_07490 ENOG4108Z9W Outer membrane porin DM57_07495 ENOG4107S2Z UPF0761 membrane protein DM57_07505 ENOG4105E5N succinylglutamate desuccinylase aspartoacylase DM57_07515 ENOG4105EAB amino acid AbC transporter DM57_07525 ENOG4105DEN Luciferase family DM57_07540 ENOG4105CDA abc transporter atp-binding protein DM57_07545 ENOG4105EAB amino acid AbC transporter DM57_07555 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DM57_07565 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein DM57_07570 ENOG4108MG3 formate dehydrogenase DM57_07575 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) DM57_07580 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) DM57_07585 ENOG4105EM7 Selenocysteine-specific translation elongation factor DM57_07605 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DM57_07665 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_07675 ENOG4105BZU Histidine kinase DM57_07685 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_07690 ENOG4105JQN Transcriptional regulator DM57_07705 ENOG4105C5Q Transcriptional regulator DM57_07715 ENOG4105DJG MaoC domain protein dehydratase DM57_07720 ENOG4105CYC Transferase DM57_07725 ENOG4105C7K acetolactate synthase DM57_07765 ENOG4108TN6 type iii secretion DM57_07775 ENOG4108JIR Flagellum-specific ATP synthase DM57_07890 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DM57_07900 ENOG4105CZX twitching motility protein DM57_07925 ENOG4107QHF type ii secretion system protein e DM57_07950 ENOG4105K44 type iii secretion DM57_07980 ENOG4105CYW agmatinase DM57_08000 ENOG4105CAF HipA N-terminal domain protein DM57_08015 ENOG4107EEX Cellulose synthase regulator protein DM57_08020 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) DM57_08045 ENOG4107QZ7 Cellulose synthase catalytic subunit DM57_08050 ENOG4105D1V cellulose synthase operon protein YhjU DM57_08070 ENOG4108IY8 ABC, transporter DM57_08075 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DM57_08085 ENOG4105NNS Autoinducer synthesis protein DM57_08100 ENOG4105CEY Amp-dependent synthetase and ligase DM57_08110 ENOG4105CJ3 phosphate transporter DM57_08125 ENOG4108ZRZ Transcriptional regulator (AsnC family) DM57_08160 ENOG4105CSH Transporter DM57_08205 ENOG4108RBT type iii secretion DM57_08215 ENOG4105Y7Q type iii secretion DM57_08220 ENOG4108RC9 Type III secretion system protein DM57_08225 ENOG4105YY8 Transcriptional regulator DM57_08230 ENOG4105K44 type iii secretion DM57_08235 ENOG4108N8R Invasion protein DM57_08240 ENOG4108HR8 type iii secretion DM57_08250 ENOG4108JIR Flagellum-specific ATP synthase DM57_08270 ENOG41075IY surface presentation of antigens protein SpaP DM57_08280 ENOG4108TN6 type iii secretion DM57_08305 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS DM57_08320 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DM57_08325 ENOG4105FTC Lytic transglycosylase catalytic DM57_08350 ENOG4105WH1 Two component transcriptional regulator luxr family DM57_08390 ENOG4107F3C Hemin uptake protein DM57_08400 ENOG4105EUB pirin domain protein DM57_08405 ENOG4105JQN Transcriptional regulator DM57_08420 ENOG4108R86 Transcriptional regulator DM57_08425 ENOG4107HP6 Transcriptional regulator DM57_08430 ENOG4105CHU acetyl-coa acetyltransferase DM57_08440 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor DM57_08465 ENOG4105C26 Dehydrogenase DM57_08470 ENOG4108JPW Aminotransferase DM57_08485 ENOG4108K8U Glycerol operon regulatory protein DM57_08495 ENOG4108Z9W Outer membrane porin DM57_08515 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) DM57_08545 ENOG4105CBN LysR family transcriptional regulator DM57_08555 ENOG4105C1P efflux transporter, rnd family, mfp subunit DM57_08595 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DM57_08605 ENOG4105CEY Amp-dependent synthetase and ligase DM57_08610 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DM57_08635 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DM57_08665 ENOG4105D01 (LipO)protein DM57_08675 ENOG4108HRD Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DM57_08680 ENOG4108UMI ABC transporter, permease DM57_08690 ENOG4107T8P acyl-Coa dehydrogenase DM57_08700 ENOG41073TP transcriptional regulator DM57_08705 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DM57_08710 ENOG4107QR9 Iron-sulfur cluster binding protein DM57_08715 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DM57_08720 ENOG4105DAA L-lactate DM57_08725 ENOG4108SB3 DoxX Family DM57_08740 ENOG4105DG4 malate L-lactate dehydrogenase DM57_08750 ENOG4107QTZ amino acid DM57_08760 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DM57_08770 ENOG41080HI glycine oxidase DM57_08830 ENOG4105VEQ Cold shock protein DM57_08850 ENOG4105C5I Dehydrogenase DM57_08865 ENOG4105BZU Histidine kinase DM57_08880 ENOG41079KZ Major Facilitator Superfamily DM57_08895 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) DM57_08905 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DM57_08930 ENOG4105H63 Glycosyl transferase, family 2 DM57_08945 ENOG4105CW7 secretion protein, HlyD family DM57_08960 ENOG4105D7W serine acetyltransferase DM57_08970 ENOG4105ESN nucleotide-binding protein DM57_08975 ENOG4105C9B Cysteine desulfurase DM57_08980 ENOG4105CPW cytochrome b561 DM57_08990 ENOG41080HT Transcriptional regulator, arsr family DM57_08995 ENOG4105MD1 YeeE YedE family protein DM57_09005 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase DM57_09020 ENOG4105JQZ Methyltransferase DM57_09040 ENOG4105FDP GntR family transcriptional regulator DM57_09055 ENOG4105EW9 transcriptional regulator AsnC family DM57_09070 ENOG4105E7U AraC family transcriptional regulator DM57_09090 ENOG4105CQB FAD linked oxidase domain protein DM57_09095 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DM57_09130 ENOG4107S1E Beta-lactamase DM57_09135 ENOG4105C94 Transporter DM57_09145 ENOG4105D44 asparaginase DM57_09150 ENOG4105DEF Extracellular solute-binding protein, family 5 DM57_09155 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DM57_09160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DM57_09185 ENOG4105DDW LysR family Transcriptional regulator DM57_09210 ENOG4108VQJ O-methyltransferase DM57_09215 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DM57_09235 ENOG4105DVH amino acid DM57_09250 ENOG4107QRT dEAD DEAH box helicase DM57_09265 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DM57_09270 ENOG4105DFG type I secretion outer membrane protein DM57_09285 ENOG4108JJA ABC, transporter DM57_09340 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DM57_09350 ENOG4107RCI amp-dependent synthetase and ligase DM57_09395 ENOG4105CSV Glutaminase DM57_09405 ENOG4107EXC regulatoR DM57_09410 ENOG4105JJR Histidine kinase DM57_09425 ENOG41090Y2 cytochrome C DM57_09470 ENOG4105DHQ Histidine kinase DM57_09475 ENOG4105XJC Two component transcriptional regulator (Winged helix family DM57_09560 ENOG4105T0Z Conserved Protein DM57_09565 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_09585 ENOG4105CCU oxidase (Subunit III) DM57_09625 ENOG4105CF7 AraC family transcriptional regulator DM57_09640 ENOG4107T8P acyl-Coa dehydrogenase DM57_09650 ENOG4105JJR Histidine kinase DM57_09655 ENOG4107EXC regulatoR DM57_09670 ENOG4108V8F Transcriptional regulator, MarR family DM57_09685 ENOG4105C26 Dehydrogenase DM57_09690 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase DM57_09715 ENOG4108Z9W Outer membrane porin DM57_09720 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DM57_09730 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC DM57_09740 ENOG4105DHQ Histidine kinase DM57_09745 ENOG4105QVC MOSC domain-containing protein DM57_09750 ENOG4108Z9W Outer membrane porin DM57_09785 ENOG41067HS methyltransferase DM57_09820 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DM57_09825 ENOG4107S9B Shikimate dehydrogenase DM57_09830 ENOG4105DJB Major Facilitator Superfamily DM57_09850 ENOG4105D81 ABC transporter, permease DM57_09910 ENOG4105D6S protein involved in catabolism of external DNA DM57_09915 ENOG4105CPC Aldo Keto reductase DM57_09930 ENOG4105CGF Aromatic amino acid aminotransferase DM57_09935 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DM57_09945 ENOG4105WP5 DM57_09955 ENOG4105HEE Binding Domain protein DM57_09960 ENOG4108ZJF Glcg protein DM57_10005 ENOG4108WUH Transcriptional regulator, TetR family DM57_10020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DM57_10030 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DM57_10040 ENOG4105F4G Membrane DM57_10050 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DM57_1006 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DM57_1007 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase DM57_10075 ENOG4107RYR Transcriptional regulator, Crp Fnr family DM57_10080 ENOG4105CEY Amp-dependent synthetase and ligase DM57_10095 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DM57_10100 ENOG4107QZ7 Cellulose synthase catalytic subunit DM57_1011 ENOG4108IYU L-aspartate oxidase DM57_1012 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DM57_10140 ENOG4105EVZ LysR family transcriptional regulator DM57_10145 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DM57_1015 ENOG4105EGS Mechanosensitive ion channel DM57_10150 ENOG4105C26 Dehydrogenase DM57_1017 ENOG4108V3E phosphoribosylglycinamide formyltransferase DM57_1018 ENOG4105DTN riboflavin biosynthesis protein ribF DM57_10180 ENOG4105CE7 Amidase, hydantoinase carbamoylase family DM57_1019 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DM57_10190 ENOG4105EJC lysr family transcriptional regulator DM57_10200 ENOG4105EJC lysr family transcriptional regulator DM57_1021 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DM57_10225 ENOG4108UAJ Transcriptional regulator DM57_10230 ENOG4105C26 Dehydrogenase DM57_10240 ENOG4105CUB amino acid DM57_10255 ENOG4108Z9W Outer membrane porin DM57_10270 ENOG4105XYF acetyltransferase DM57_10275 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DM57_1028 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DM57_10290 ENOG4108Z9W Outer membrane porin DM57_10295 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DM57_103 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase DM57_10305 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DM57_1031 ENOG4105CV8 reductase DM57_10310 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DM57_1032 ENOG4105FDP GntR family transcriptional regulator DM57_10320 ENOG4105NNS Autoinducer synthesis protein DM57_10330 ENOG4105VJY transcriptional regulator DM57_10340 ENOG4107RN3 metallophosphoesterase DM57_1035 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_10355 ENOG4107HP6 Transcriptional regulator DM57_10390 ENOG4107HP6 Transcriptional regulator DM57_10395 ENOG4105CHR reductase DM57_104 ENOG4108R85 Short chain dehydrogenase DM57_10400 ENOG4105C7K acetolactate synthase DM57_10410 ENOG4105C26 Dehydrogenase DM57_10425 ENOG4105C54 Major Facilitator superfamily DM57_10430 ENOG4105EUR Domain-Containing protein DM57_10435 ENOG4105UYK outer membrane protein a DM57_10450 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DM57_10455 ENOG4105F7P transcriptional regulator AsnC family DM57_1047 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DM57_1048 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DM57_1049 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DM57_10490 ENOG4105C3M thioredoxin reductase DM57_10515 ENOG4105GVF (ABC) transporter DM57_1054 ENOG4105VEQ Cold shock protein DM57_10540 ENOG4105C8Q Methyl-accepting chemotaxis DM57_10545 ENOG4105C8Q Methyl-accepting chemotaxis DM57_1056 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_10570 ENOG4107SVH Potassium channel protein DM57_10590 ENOG4107UWA esterase DM57_10600 ENOG4108Z9W Outer membrane porin DM57_10610 ENOG4108K5P (LipO)protein DM57_1062 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DM57_10625 ENOG4105ETT transcriptional Regulator, LysR family DM57_1063 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DM57_10645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DM57_1065 ENOG4107T7U Sulfatase DM57_10650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DM57_10660 ENOG4108UQS dipeptidase DM57_1068 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DM57_10685 ENOG4105CS6 Rhs element vgr protein DM57_10695 ENOG4105CNA YD repeat protein DM57_1070 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DM57_1072 ENOG4108DMA Nad-dependent epimerase dehydratase DM57_10725 ENOG4105F0F Oxalate decarboxylase DM57_10730 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DM57_10735 ENOG4108Z12 YiaAB two helix domain-containing protein DM57_10740 ENOG4105FFC UPF0187 protein DM57_10745 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit DM57_10750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DM57_10765 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DM57_10770 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DM57_10795 ENOG4108SB3 DoxX Family DM57_10800 ENOG4108Z9W Outer membrane porin DM57_10815 ENOG4105DSP amino acid AbC transporter DM57_10820 ENOG4106YG3 ABC transporter DM57_10825 ENOG4108JEH abc transporter atp-binding protein DM57_1083 ENOG4105ECX polysaccharide export DM57_1084 ENOG4107V52 polysaccharide export DM57_1086 ENOG4105E12 capsule polysaccharide DM57_10865 ENOG4108HRK Histidine kinase DM57_10880 ENOG4108NEV two component transcriptional regulator, LytTR family DM57_10885 ENOG4108VAC response regulator DM57_1089 ENOG4105D64 Mechanosensitive ion channel DM57_10890 ENOG4105CH6 catalase DM57_1090 ENOG4105DQR SNARE associated Golgi DM57_1091 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DM57_10915 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase DM57_10920 ENOG41062T2 Acyl carrier protein DM57_10925 ENOG4108KQ6 Enoyl-CoA hydratase DM57_10930 ENOG4108MGH Enoyl-CoA hydratase DM57_10945 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DM57_1095 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) DM57_10965 ENOG4107QKG PfaD family DM57_1097 ENOG4105DJ0 Poly(A) Polymerase DM57_10975 ENOG4107SQU synthase DM57_1098 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DM57_10980 ENOG4107SQU synthase DM57_10980 ENOG4107SQU synthase DM57_10990 ENOG4107SQU synthase DM57_11 ENOG4108IG5 Transcriptional regulator DM57_11000 ENOG4105CMQ Chloride channel DM57_1101 ENOG4105CRQ synthase (Component I) DM57_11015 ENOG4105CR8 Transcriptional regulator DM57_11040 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DM57_1106 ENOG4105VEJ Heat shock protein DM57_11065 ENOG4108YYC ycei family DM57_11080 ENOG4108SF5 RNA Polymerase DM57_11085 ENOG4108S3W Anti-feci sigma factor, fecr DM57_1109 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DM57_11095 ENOG4105CNN ABC, transporter DM57_111 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DM57_1110 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DM57_11100 ENOG4105CNN ABC, transporter DM57_1111 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DM57_1112 ENOG4105QD6 exported protein DM57_1114 ENOG4105D1U peptidase U62 modulator of DNA gyrase DM57_11145 ENOG4105CEY Amp-dependent synthetase and ligase DM57_1115 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DM57_11180 ENOG4108I6A alcohol dehydrogenase DM57_11185 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DM57_11200 ENOG4105CHR reductase DM57_11205 ENOG4105CBN LysR family transcriptional regulator DM57_1121 ENOG4105E7U AraC family transcriptional regulator DM57_1122 ENOG4105CYM Glutathione S-transferase DM57_11225 ENOG4105CSH Transporter DM57_1123 ENOG4105CYM Glutathione S-transferase DM57_11230 ENOG4105CE7 Amidase, hydantoinase carbamoylase family DM57_11245 ENOG4105EUJ GTP cyclohydrolase i DM57_1125 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DM57_11260 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DM57_1127 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DM57_11270 ENOG4107QZF nitrite reductase NADPH large subunit DM57_11275 ENOG4105WZK nitrite reductase NADPH small subunit DM57_11280 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DM57_11290 ENOG4105CJN penicillin-binding protein DM57_11295 ENOG4105DZ1 carboxypeptidase DM57_11305 ENOG4105CMG Carbohydrate kinase DM57_11315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DM57_11320 ENOG4105CPQ Dehydrogenase DM57_1134 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) DM57_11345 ENOG4106UW1 Major Facilitator superfamily DM57_1135 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DM57_11350 ENOG4105MVE transcriptional regulator DM57_1136 ENOG4105D0A hydroxylase DM57_1137 ENOG4107RAQ aminopeptidase DM57_1138 ENOG4108U78 Glutathione S-transferase DM57_11390 ENOG4105CKD glutathione-regulated potassium-efflux system protein DM57_114 ENOG4105EJC lysr family transcriptional regulator DM57_1140 ENOG4105CBC glutamate synthase DM57_1143 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DM57_11435 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DM57_1144 ENOG4105W8H transhydrogenase (subunit alpha DM57_1145 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DM57_11450 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) DM57_11455 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DM57_11460 ENOG4105BZS acriflavin resistance protein DM57_11465 ENOG4105ENT Efflux transporter rnd family, mfp subunit DM57_1148 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DM57_11500 ENOG4105D5Q Arginine ornithine antiporter DM57_1152 ENOG4105DY2 Paraquat-inducible protein b DM57_1153 ENOG4105F1S paraquat-inducible protein a DM57_1156 ENOG4108YYC ycei family DM57_1157 ENOG4108YYC ycei family DM57_1159 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DM57_116 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DM57_1160 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DM57_1161 ENOG4105VIE preprotein translocase, subunit YajC DM57_11615 ENOG4107QX3 carboxylase DM57_1162 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DM57_11620 ENOG4105C1G acyl-Coa dehydrogenase DM57_11635 ENOG4105DSQ Nitric oxide reductase DM57_1164 ENOG4105CB5 ATP-dependent DNA helicase recG DM57_11640 ENOG4105CEI nitrite reductase DM57_11645 ENOG4105FUY alpha subunit DM57_1165 ENOG4105C5Q Transcriptional regulator DM57_11675 ENOG4105C54 Major Facilitator superfamily DM57_11690 ENOG4105XJC Two component transcriptional regulator (Winged helix family DM57_117 ENOG4105M4H endoribonuclease L-psp DM57_1170 ENOG4107YPT transcriptional regulator DM57_11710 ENOG4105CJ2 (LipO)protein DM57_11715 ENOG4105C26 Dehydrogenase DM57_11720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DM57_1173 ENOG4108TXN phosphonate metabolism protein DM57_11730 ENOG4105ETT transcriptional Regulator, LysR family DM57_11735 ENOG4105CJP fad dependent oxidoreductase DM57_11750 ENOG4105E98 transcriptional regulator DeoR family DM57_11755 ENOG4108I5G Major Facilitator superfamily DM57_11760 ENOG4105DEI Mannitol dehydrogenase DM57_11770 ENOG4105CXK mandelate racemase muconate lactonizing DM57_11775 ENOG4105CPQ Dehydrogenase DM57_1179 ENOG4105ENV phosphonate C-P lyase system protein PhnK DM57_118 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DM57_1180 ENOG4105HRV phosphonate c-p lyase system protein phnl DM57_11800 ENOG4105EQN UPF0261 protein DM57_1181 ENOG4105FD8 phosphonate metabolism protein PhnM DM57_1182 ENOG4105D5T phosphonate abc transporter DM57_11830 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DM57_1186 ENOG4105II7 pyrroline-5-carboxylate reductase DM57_1187 ENOG4105DFA alanine racemase domain protein DM57_1188 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DM57_1189 ENOG4105EU8 FAD linked oxidase domain protein DM57_1190 ENOG4105CQB FAD linked oxidase domain protein DM57_11900 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_1191 ENOG4105CQB FAD linked oxidase domain protein DM57_1192 ENOG4108WBT adenosyltransferase DM57_1193 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DM57_11960 ENOG4105EUJ GTP cyclohydrolase i DM57_1198 ENOG4105EKE dihydroorotase DM57_1199 ENOG4105E7A Glutamine amidotransferase DM57_11990 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS DM57_12000 ENOG4105C85 amino acid DM57_12015 ENOG4105EMU Dehydrogenase DM57_12055 ENOG4105WH1 Two component transcriptional regulator luxr family DM57_1206 ENOG4105CDA abc transporter atp-binding protein DM57_1207 ENOG4105DRP amino acid AbC transporter DM57_1208 ENOG4105EAD ABC transporter DM57_12085 ENOG4107SCK Monooxygenase DM57_1209 ENOG4107RP9 extracellular solute-binding protein, family 3 DM57_121 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DM57_12100 ENOG4107MM9 BNR Asp-box repeat-containing protein DM57_12110 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DM57_12115 ENOG4105E2B Taurine dioxygenase DM57_1212 ENOG4105D82 Glutamate dehydrogenase DM57_1213 ENOG4107YNJ LysR family Transcriptional regulator DM57_12130 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DM57_1215 ENOG4107QTF adenylosuccinate lyase DM57_12160 ENOG4105DN3 alpha-2-macroglobulin domain protein DM57_12165 ENOG4105BZ4 penicillin-binding protein DM57_1217 ENOG4105C6Z Gluconate DM57_12175 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DM57_1218 ENOG4108UHU Aldolase DM57_12180 ENOG4105BZU Histidine kinase DM57_1219 ENOG4105C01 Dihydroxy-acid dehydratase DM57_1220 ENOG4106KNT transcriptional regulator DM57_12215 ENOG4105CGF Aromatic amino acid aminotransferase DM57_1222 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) DM57_12220 ENOG4105C85 amino acid DM57_12225 ENOG4108YXU transcriptional regulator AsnC family DM57_1223 ENOG4105DJF DNA polymerase III, delta' subunit DM57_12230 ENOG4105BZU Histidine kinase DM57_12245 ENOG4108UT2 hemolysin iii DM57_1225 ENOG4105C8T Leucyl-tRNA synthetase DM57_12280 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS DM57_1229 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DM57_1230 ENOG41090R7 Ferric uptake DM57_12325 ENOG4105CHR reductase DM57_1233 ENOG4105DHG Allantoate amidinohydrolase DM57_12335 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr DM57_1234 ENOG4105CK2 sodium dicarboxylate symporter DM57_12345 ENOG4105CTX dehydratase DM57_12355 ENOG4105CNN ABC, transporter DM57_1236 ENOG4105DND Transcriptional regulator DM57_12360 ENOG4105C2J ABC transporter DM57_1237 ENOG4107B2H carbonic anhydrase DM57_12380 ENOG4108Z9W Outer membrane porin DM57_12385 ENOG4108SC4 )-transporter DM57_1239 ENOG4105EQ0 Major Facilitator superfamily DM57_1240 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DM57_12400 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase DM57_1241 ENOG4105CV1 Transketolase (EC 2.2.1.1) DM57_1242 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DM57_1244 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DM57_12440 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DM57_12460 ENOG4105WH1 Two component transcriptional regulator luxr family DM57_1247 ENOG4105C6K Malic enzyme DM57_1248 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DM57_12480 ENOG4105CA0 peroxidase DM57_1249 ENOG4108ZAI phosphatidylglycerophosphatase a DM57_125 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DM57_1250 ENOG4107TH8 cina domain protein DM57_12500 ENOG4105CHR reductase DM57_1251 ENOG4105SKN orotidine 5''-phosphate decarboxylase DM57_12520 ENOG4105DZC cytosine deaminase DM57_12525 ENOG4107YHD transcriptional regulator DM57_1253 ENOG4105FGE Short-chain dehydrogenase reductase Sdr DM57_12530 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin DM57_1254 ENOG4105CNN ABC, transporter DM57_12540 ENOG4108Z9W Outer membrane porin DM57_1255 ENOG4105C2J ABC transporter DM57_12555 ENOG4105CR8 Transcriptional regulator DM57_1257 ENOG4105CHR reductase DM57_1259 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 DM57_12595 ENOG4108Z9W Outer membrane porin DM57_126 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DM57_1260 ENOG4105J4Q Transcriptional regulator DM57_1263 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase DM57_12630 ENOG4107YCY Transcriptional regulator DM57_12635 ENOG4105ZXK Dehydrogenase DM57_1264 ENOG4105E2X shikimate dehydrogenase DM57_12645 ENOG4105FB2 class II Aldolase DM57_12650 ENOG4105CSP Major Facilitator Superfamily DM57_12655 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DM57_1266 ENOG4105IPS esterase DM57_12660 ENOG4105EXW epimerase dehydratase DM57_1267 ENOG4105DFU Cell wall formation (By similarity) DM57_12685 ENOG4105ECQ AraC Family Transcriptional Regulator DM57_1269 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DM57_12695 ENOG4108IJ7 Glycine betaine DM57_1270 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DM57_12700 ENOG4108YYH Nadph-dependent fmn reductase DM57_1271 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DM57_12715 ENOG41085FC arsR family transcriptional regulator DM57_1272 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DM57_12730 ENOG4105D6J arsenicaL-resistance protein DM57_1275 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DM57_12795 ENOG4105E39 Enoyl-CoA hydratase DM57_1280 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DM57_12805 ENOG4105CHU acetyl-coa acetyltransferase DM57_1281 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DM57_12810 ENOG4108UKI Enoyl-CoA hydratase DM57_12825 ENOG4105CA3 membrane-bound lytic murein transglycosylase DM57_12835 ENOG4105NWN ApaG protein DM57_12845 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DM57_1285 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DM57_12855 ENOG4105DDQ anthranilate synthase DM57_1286 ENOG4108UGV hypoxanthine phosphoribosyltransferase DM57_1287 ENOG41076UM multiple antibiotic resistance (MarC)-related protein DM57_12875 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DM57_12880 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DM57_12890 ENOG4105T95 Thiol disulfide interChange protein DM57_12895 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DM57_12910 ENOG4105C3G gtp-binding protein DM57_12940 ENOG4106IDA glycerophosphoryl diester phosphodiesterase DM57_1295 ENOG4105EAH synthase DM57_12955 ENOG4105C5H ABC transporter DM57_12965 ENOG4105D3W isochorismatase DM57_12975 ENOG4105DC7 peptidase M24 DM57_13 ENOG4105BZS acriflavin resistance protein DM57_13005 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DM57_13015 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DM57_13020 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DM57_13025 ENOG4107QTZ amino acid DM57_1303 ENOG4108JU6 CBS domain protein DM57_1304 ENOG4107QHF type ii secretion system protein e DM57_1306 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) DM57_13060 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme DM57_1307 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DM57_13070 ENOG4105ECQ AraC Family Transcriptional Regulator DM57_1309 ENOG4105M6F mutator MutT protein DM57_13095 ENOG4105CBG Sulfatase DM57_1311 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DM57_13125 ENOG4105DVW rieske (2Fe-2S) DM57_13135 ENOG4105C10 Electron transfer flavoprotein DM57_13140 ENOG4105DF6 Fe-S oxidoreductase DM57_13155 ENOG4108IGT Dipeptidase DM57_1316 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DM57_13160 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DM57_13165 ENOG4105ECQ AraC Family Transcriptional Regulator DM57_1317 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DM57_13170 ENOG4105E2A Dehydrogenase DM57_13175 ENOG4105EDQ levansucrase EC 2.4.1.10 DM57_1318 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) DM57_13180 ENOG4108HKT sucrose-6-phosphate hydrolase DM57_13185 ENOG4105CW7 secretion protein, HlyD family DM57_13200 ENOG4105H63 Glycosyl transferase, family 2 DM57_13205 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_1325 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) DM57_1326 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DM57_1327 ENOG4105CJN penicillin-binding protein DM57_1328 ENOG4105N8N Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DM57_13280 ENOG4105CS6 Rhs element vgr protein DM57_13285 ENOG4105CS6 Rhs element vgr protein DM57_13290 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_1332 ENOG4108Z9W Outer membrane porin DM57_13345 ENOG4105F38 ABC transporter, permease DM57_13355 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DM57_13375 ENOG4105D05 Receptor DM57_13385 ENOG4105CPW cytochrome b561 DM57_13395 ENOG4108K5P (LipO)protein DM57_13410 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DM57_13420 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DM57_13425 ENOG4105ETS cytosine purines uracil thiamine allantoin DM57_1344 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit DM57_1345 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit DM57_1346 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit DM57_13460 ENOG4105CS6 Rhs element vgr protein DM57_13465 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_1347 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit DM57_1348 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DM57_13485 ENOG4108WC9 type VI secretion system effector, hcp1 family DM57_1352 ENOG4108XM1 transcriptional regulator AsnC family DM57_13520 ENOG4106VK6 Flagellar motor protein DM57_1353 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase DM57_1356 ENOG4105C6K Malic enzyme DM57_13565 ENOG4105CHR reductase DM57_1357 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DM57_13570 ENOG4105ETT transcriptional Regulator, LysR family DM57_1358 ENOG4108V1U phospholipid-binding protein DM57_13580 ENOG4105DND Transcriptional regulator DM57_13590 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) DM57_136 ENOG4105GJM (LipO)protein DM57_1360 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DM57_13600 ENOG4105C57 major facilitator superfamily DM57_13605 ENOG4107QI6 Cysteine desulfurase DM57_13620 ENOG4105CSH Transporter DM57_13625 ENOG4105ETT transcriptional Regulator, LysR family DM57_1363 ENOG4105EIF outer membrane protein W DM57_13630 ENOG4105DMF Dehydrogenase DM57_13635 ENOG4105ERH Fumarylacetoacetate hydrolase DM57_13655 ENOG4105CD5 CoA-binding domain protein DM57_13660 ENOG4107M1U Histone family protein nucleoid-structuring protein H-NS DM57_1367 ENOG4105CRE cytochrome C DM57_1368 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) DM57_13680 ENOG4108JUA Transcriptional regulator DM57_13685 ENOG4105CY2 Citrate transporter DM57_1369 ENOG4106RE7 Cytochrome DM57_1370 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DM57_13700 ENOG4105J5J Outer membrane porin DM57_13705 ENOG4108JQ7 (ABC) transporter DM57_1371 ENOG4105D52 delta-aminolevulinic acid dehydratase DM57_13710 ENOG4105C3U ABC transporter DM57_13715 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DM57_1372 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DM57_13720 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DM57_13725 ENOG4107QSI ABC, transporter DM57_13735 ENOG4105DUX Transporter DM57_1380 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) DM57_13800 ENOG4105CBX hi0933 family DM57_13805 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DM57_1381 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DM57_13820 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) DM57_1384 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DM57_13845 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) DM57_13860 ENOG4105CEP NADH dehydrogenase DM57_13865 ENOG4105C2M dna polymerase I DM57_13870 ENOG4108URH decarboxylase DM57_13880 ENOG4105EWC Purine nucleoside phosphorylase DM57_1389 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DM57_13895 ENOG4105ED4 portal protein DM57_13900 ENOG4105FYV Amp nucleosidase DM57_1391 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DM57_13925 ENOG4105K56 Transcriptional regulator DM57_13930 ENOG4108ZHJ Organic hydroperoxide resistance protein DM57_13945 ENOG4105MH5 phosphoesterase PA-phosphatase related protein DM57_13950 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DM57_13955 ENOG4105E0C molybdate abc transporter DM57_13960 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DM57_13965 ENOG4105F4R Transcriptional regulator mode DM57_1398 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DM57_13980 ENOG4105CBN LysR family transcriptional regulator DM57_13995 ENOG4105C37 (CBS) domain DM57_14000 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DM57_14005 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) DM57_14020 ENOG4105DMF Dehydrogenase DM57_1404 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DM57_1405 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DM57_14055 ENOG4105D3Q Sugar transferase DM57_1407 ENOG4105C9U ATP-dependent DNA helicase RecQ DM57_14075 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DM57_14080 ENOG4108RAC Rubrerythrin DM57_14085 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DM57_14090 ENOG4105CHP RNA polymerase DM57_14100 ENOG4105GRZ Ycii-related protein DM57_14105 ENOG4105GRZ Ycii-related protein DM57_14125 ENOG4105IPI Membrane DM57_14135 ENOG4107ENK receptor DM57_14145 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DM57_1416 ENOG4105PM1 preprotein translocase subunit SecE DM57_14165 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DM57_14210 ENOG4105EZR dyp-type peroxidase family protein DM57_14215 ENOG4108JJ7 ABC transporter DM57_1425 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) DM57_14255 ENOG4107R4J Chloride channel DM57_1426 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) DM57_14265 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DM57_1427 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DM57_14270 ENOG4105CBS Chea signal transduction histidine kinase DM57_14280 ENOG4108KTQ Methyltransferase DM57_14290 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DM57_14295 ENOG4105ECM Sensor protein basS pmrB DM57_1431 ENOG4108JQC penicillin-binding protein 1A DM57_14315 ENOG4105C7K acetolactate synthase DM57_14320 ENOG4105EEQ Na H antiporter DM57_14340 ENOG4107RZC phospholipase d DM57_14345 ENOG4105K59 histidine triad (HIT) protein DM57_1435 ENOG4105E4G Type IV pilus DM57_1436 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DM57_1438 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein DM57_14395 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DM57_1440 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component DM57_14400 ENOG4105CCU oxidase (Subunit III) DM57_1441 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component DM57_1442 ENOG4108IJ9 (ABC) transporter DM57_14420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DM57_14425 ENOG4108R6W Transcriptional regulator, ARAC family DM57_1443 ENOG4107T6V glycerophosphoryl diester phosphodiesterase DM57_14435 ENOG4108KB2 LysR family Transcriptional regulator DM57_14440 ENOG4105FUY alpha subunit DM57_14445 ENOG4108UKV benzoate 1,2-dioxygenase DM57_14450 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein DM57_14455 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase DM57_14470 ENOG4105D3W isochorismatase DM57_14505 ENOG4108IQI permease DM57_1453 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DM57_14530 ENOG4105BZU Histidine kinase DM57_1455 ENOG4105DHJ ABC, transporter DM57_1456 ENOG4105CY3 ABC transporter, permease DM57_14565 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DM57_1457 ENOG4107PE3 Mammalian cell entry related domain protein DM57_14570 ENOG4105H3G oxidoreductase DM57_14580 ENOG4105CAN Short-chain dehydrogenase reductase Sdr DM57_14585 ENOG4107EEY synthase DM57_146 ENOG4108M0I Transcriptional regulator DM57_14605 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DM57_1461 ENOG4105DA5 (ABC) transporter DM57_14615 ENOG4105CDA abc transporter atp-binding protein DM57_1462 ENOG4105E3A (ABC) transporter DM57_14620 ENOG4105E5Q amino acid AbC transporter DM57_14625 ENOG4107R0W ABC transporter DM57_14635 ENOG4105EWU Squalene--hopene cyclase DM57_1464 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DM57_14645 ENOG4105FE1 phytoene synthase DM57_14655 ENOG4105BZU Histidine kinase DM57_1466 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DM57_14665 ENOG4105EFQ Two component transcriptional regulator (Winged helix family DM57_1467 ENOG4105CIH Imidazole acetol-phosphate transaminase DM57_14680 ENOG4108WQI RNA Polymerase DM57_1469 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DM57_14690 ENOG4105K89 arsenate reductase DM57_14695 ENOG4107QJE Chromosome Partitioning Protein DM57_147 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DM57_1470 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DM57_14745 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DM57_1476 ENOG4105K59 histidine triad (HIT) protein DM57_14760 ENOG4105J7D transcriptional regulator DM57_14775 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DM57_1478 ENOG4107Z6S Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) DM57_14780 ENOG4105EJC lysr family transcriptional regulator DM57_1479 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DM57_148 ENOG4105FE9 pseudouridine synthase DM57_1480 ENOG4105C0H protease DM57_1481 ENOG4107QNR UPF0135 protein DM57_1482 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DM57_1483 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DM57_1484 ENOG4105EIX cytochrome c1 DM57_1485 ENOG4107MKT Stringent starvation protein a DM57_1486 ENOG4105KB2 stringent starvation protein b DM57_14875 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DM57_1489 ENOG4105ED4 portal protein DM57_1490 ENOG4105YES addiction module antidote protein DM57_1491 ENOG4105VUH addiction module killer protein DM57_1495 ENOG4105VS8 Flagellar biosynthetic protein fliq DM57_1496 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DM57_1497 ENOG4108Z4X TRANSCRIPTIONal DM57_1498 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) DM57_15 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon DM57_150 ENOG4105CHV Transcription elongation factor NusA DM57_1500 ENOG4105D2X ABC transporter substrate-binding protein DM57_1502 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DM57_1505 ENOG4108Z9W Outer membrane porin DM57_1508 ENOG4108Z9W Outer membrane porin DM57_15095 ENOG4105CPT Alpha beta hydrolase DM57_1510 ENOG4108IV0 ABC, transporter DM57_1511 ENOG4105C0Z ABC transporter DM57_1512 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DM57_1520 ENOG4105K7K Transcriptional regulator DM57_1524 ENOG4105CN7 Flagellar biosynthetic protein FliP DM57_15245 ENOG4105C7B Threonine dehydratase DM57_1526 ENOG4105DD5 Flagellar motor switch protein DM57_1527 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DM57_1529 ENOG41067MG lrgb family DM57_153 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DM57_1531 ENOG4105CMU LysR family (Transcriptional regulator DM57_1532 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_1533 ENOG4105K56 Transcriptional regulator DM57_1535 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DM57_1539 ENOG4108RTD type II secretion system protein K DM57_154 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_1541 ENOG4105X5Z General secretion pathway protein I DM57_1542 ENOG41069X0 general secretion pathway protein h DM57_1543 ENOG4108VAU general secretion pathway protein G DM57_1545 ENOG4105D7Q type ii secretion system DM57_1546 ENOG4107QHF type ii secretion system protein e DM57_15460 ENOG4105VEQ Cold shock protein DM57_1548 ENOG4105FTC Lytic transglycosylase catalytic DM57_1549 ENOG4105CKI cobalamin synthesis protein DM57_155 ENOG4105CW7 secretion protein, HlyD family DM57_15505 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DM57_15535 ENOG4105EHI Phosphonate ABC transporter, periplasmic DM57_1556 ENOG4105C85 amino acid DM57_1558 ENOG4105W2Z cytochrome C, class I DM57_1559 ENOG4105W4M Transport-associated protein DM57_15590 ENOG41084CK capsule polysaccharide DM57_156 ENOG4105ETP RND efflux system, outer membrane lipoprotein DM57_1560 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) DM57_1564 ENOG4105R8A Heat shock protein DM57_15655 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DM57_157 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DM57_1573 ENOG4105CD8 aminopeptidase N DM57_1576 ENOG4108MBX Secretion Protein DM57_1577 ENOG4108JJA ABC, transporter DM57_1583 ENOG4105UYK outer membrane protein a DM57_1585 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_159 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DM57_1593 ENOG4105SYT Methylenetetrahydrofolate reductase DM57_1594 ENOG41086DT Membrane protein of unknown function DM57_1596 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DM57_1599 ENOG4105D7B Flagellar biosynthesis protein flha DM57_16 ENOG4106PG1 outer membrane usher protein DM57_160 ENOG4105C7S Dehydrogenase DM57_1601 ENOG4105D00 flagellar biosynthetic protein flhB DM57_1605 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) DM57_1606 ENOG4108VYJ response regulator receiver protein DM57_1607 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DM57_16070 ENOG4105DR5 peptidase DM57_1609 ENOG4105BZU Histidine kinase DM57_161 ENOG4107QN2 dihydrolipoyl dehydrogenase DM57_1610 ENOG4105C8Q Methyl-accepting chemotaxis DM57_1611 ENOG4108V3W Chemotaxis protein, CheW DM57_1612 ENOG4105CBS Chea signal transduction histidine kinase DM57_1613 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DM57_1616 ENOG4107RD7 Flagellar Motor Protein, MotA DM57_1617 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region DM57_1619 ENOG4105E2K Glycosyl transferase (Group 1 DM57_162 ENOG4105D6Z AFG1 family ATPase DM57_1621 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DM57_1622 ENOG4105DQF Hydrolase DM57_1624 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DM57_1631 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DM57_1634 ENOG4105CHR reductase DM57_1639 ENOG4105N14 lysine exporter protein LysE YggA DM57_1641 ENOG4107Y60 (LipO)protein DM57_1643 ENOG4106B0W Curli production assembly transport component CsgG DM57_1645 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) DM57_1646 ENOG4105C8Q Methyl-accepting chemotaxis DM57_1648 ENOG4108M1A Chitin-binding protein DM57_1653 ENOG4108KU3 Integrase DM57_1655 ENOG4105MPD Cytochrome DM57_1656 ENOG4105C4R Atp-dependent dna helicase DM57_1659 ENOG4105D9R oxidoreductase DM57_1662 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DM57_1665 ENOG4105EJQ L-serine dehydratase DM57_1669 ENOG4108K3Z AraC family transcriptional regulator DM57_1670 ENOG4105C26 Dehydrogenase DM57_1672 ENOG4107FQ9 ethanolamine ammonia-lyase DM57_1673 ENOG4105CPD ethanolamine ammonia-lyase DM57_1675 ENOG4105DVH amino acid DM57_1680 ENOG4105W1Y Transcriptional regulator DM57_1682 ENOG4105CQB FAD linked oxidase domain protein DM57_1684 ENOG4105E89 ABC transporter DM57_1685 ENOG4105CHM Aminotransferase DM57_1687 ENOG4105CSU acyl-Coa dehydrogenase DM57_1690 ENOG4105C26 Dehydrogenase DM57_1692 ENOG4105C25 Primosomal protein n' DM57_1694 ENOG4105F87 Dehydratase DM57_1695 ENOG4105K4P CoA-binding domain protein DM57_1696 ENOG4105CEY Amp-dependent synthetase and ligase DM57_17 ENOG4108FZ9 Chaperone DM57_1703 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DM57_1704 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) DM57_1706 ENOG4105F4P )-transporter DM57_1707 ENOG4105FA0 parb-like partition protein DM57_1708 ENOG4107QJE Chromosome Partitioning Protein DM57_1711 ENOG4108IV0 ABC, transporter DM57_1712 ENOG4105C0Z ABC transporter DM57_1717 ENOG4105C32 Amino acid ABC transporter (Permease) DM57_1719 ENOG4108IV0 ABC, transporter DM57_1720 ENOG4105C0Z ABC transporter DM57_1722 ENOG4105C26 Dehydrogenase DM57_1723 ENOG4105CN8 Transcriptional regulator DM57_1725 ENOG4108ZRZ Transcriptional regulator (AsnC family) DM57_1726 ENOG4105MIR Phenylalanine 4-monooxygenase DM57_1727 ENOG4105KZX Pterin carbinolamine dehydratase DM57_1730 ENOG4105DHQ Histidine kinase DM57_1732 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DM57_1733 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DM57_174 ENOG41068CG regulatoR DM57_1740 ENOG4105K6T rare lipoprotein A DM57_1741 ENOG4105C5X domain protein DM57_1743 ENOG4108YXU transcriptional regulator AsnC family DM57_1752 ENOG4107RDB Major Facilitator DM57_1753 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DM57_1760 ENOG4105C2X Arabinose 5-phosphate isomerase DM57_1761 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase DM57_1764 ENOG4108IUZ ABC transporter DM57_1766 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DM57_1767 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA DM57_1768 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN DM57_1772 ENOG4105CEN a g-specific adenine glycosylase DM57_1775 ENOG4105QVB outer membrane lipoprotein LolB DM57_1778 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DM57_1780 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DM57_1781 ENOG4105CIH Imidazole acetol-phosphate transaminase DM57_1782 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DM57_1784 ENOG4106H78 methyltransferase DM57_1786 ENOG4108RXX maleylacetoacetate isomerase DM57_1787 ENOG4108IFG nitrite reductase, (NAD(P)H) DM57_1789 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DM57_1790 ENOG4108MTB glycosyl transferase family DM57_1792 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DM57_1794 ENOG41061N2 exported protein DM57_1795 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DM57_1801 ENOG4105D5T phosphonate abc transporter DM57_1802 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) DM57_1804 ENOG4105C0B DNA polymerase III (alpha subunit) DM57_1806 ENOG4105EQ0 Major Facilitator superfamily DM57_1813 ENOG4105DVA methyltransferase DM57_1815 ENOG4105CSU acyl-Coa dehydrogenase DM57_182 ENOG4105CW0 outer membrane usher protein DM57_1826 ENOG4106NZI LysR family Transcriptional regulator DM57_1827 ENOG4105FDP GntR family transcriptional regulator DM57_1828 ENOG4105CE4 GlcNAc 6-P deacetylase DM57_1829 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DM57_183 ENOG4108VCD Chaperone DM57_1830 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DM57_1831 ENOG4105CI1 PTS System DM57_1835 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DM57_1836 ENOG4105C4M (Ubiquinol oxidase) subunit I DM57_1840 ENOG4105D01 (LipO)protein DM57_1841 ENOG4105C8Q Methyl-accepting chemotaxis DM57_1845 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) DM57_1849 ENOG4107QS1 Cytochrome C Oxidase, Subunit III DM57_1851 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) DM57_1852 ENOG4105BZ9 Cytochrome C oxidase, subunit I DM57_1853 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) DM57_1855 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DM57_1856 ENOG4105MJ2 Competence protein DM57_1858 ENOG4108UVJ appr-1-p processing domain protein DM57_1862 ENOG4107YZP Rhodanese domain protein DM57_1864 ENOG4105CN1 protease DM57_1865 ENOG4105D06 uba thif-type nad fad binding protein DM57_1866 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DM57_1867 ENOG41080Z8 PHOSPHOCARRIER protein DM57_1869 ENOG4105D7Z glutathione synthase DM57_1872 ENOG4105BZU Histidine kinase DM57_1873 ENOG4108YZA Nitrogen regulatory protein pii DM57_1874 ENOG4105W0Z cytoplasmic protein DM57_1875 ENOG4105C0P Mg chelatase subunit ChlI DM57_1879 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DM57_1880 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_1884 ENOG4107QN1 sodium solute DM57_1886 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DM57_1887 ENOG4105C1G acyl-Coa dehydrogenase DM57_1888 ENOG4105X7H acyl-CoA dehydrogenase DM57_1889 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DM57_1890 ENOG4105CBN LysR family transcriptional regulator DM57_1892 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DM57_1895 ENOG4105DQ4 alcohol dehydrogenase DM57_1897 ENOG4105CF7 AraC family transcriptional regulator DM57_1899 ENOG4105EYM Major Facilitator superfamily DM57_19 ENOG4105BZ1 (ABC) transporter DM57_1902 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) DM57_1906 ENOG4105TX3 Histidine kinase DM57_1907 ENOG4108UYB regulatoR DM57_1909 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DM57_1910 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DM57_1911 ENOG4105CKI cobalamin synthesis protein DM57_1913 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DM57_1916 ENOG4105D1S lipid A biosynthesis DM57_1921 ENOG4105CPC Aldo Keto reductase DM57_1924 ENOG4105D94 Major Facilitator Superfamily DM57_1926 ENOG4105E27 serine threonine protein kinase DM57_1928 ENOG4107RGH Aldehyde dehydrogenase DM57_1934 ENOG4108JIR Flagellum-specific ATP synthase DM57_1936 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DM57_1937 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DM57_1939 ENOG4105MQ3 flagellar protein FliS DM57_1942 ENOG4105D00 flagellar biosynthetic protein flhB DM57_1945 ENOG4105CUB amino acid DM57_1946 ENOG4105WH1 Two component transcriptional regulator luxr family DM57_1949 ENOG4105DP0 ferredoxin-NADP reductase DM57_1951 ENOG4105X23 Endonuclease Exonuclease phosphatase DM57_1954 ENOG4105D5U fad dependent oxidoreductase DM57_1955 ENOG4105VMH Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria (By similarity) DM57_1956 ENOG4105CSH Transporter DM57_1957 ENOG4105DEF Extracellular solute-binding protein, family 5 DM57_1958 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DM57_196 ENOG4105CMT Dihydroxyacetone kinase DM57_1961 ENOG4105C3U ABC transporter DM57_1962 ENOG4108JQ7 (ABC) transporter DM57_1967 ENOG4107R7A Allophanate hydrolase subunit 2 DM57_1968 ENOG4105P4J Allophanate hydrolase, subunit 1 DM57_1970 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DM57_1971 ENOG4107SC1 transglycosylase DM57_1977 ENOG4105M9M anti-sigma28 factor FlgM DM57_1978 ENOG4105CKS Flagella basal body P-ring formation protein flgA DM57_198 ENOG4105C8Q Methyl-accepting chemotaxis DM57_1980 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DM57_1981 ENOG4108ZC9 flagellar basal-body rod protein flgc DM57_1982 ENOG4105W00 Flagellar hook capping protein DM57_1983 ENOG4105BZE flagellar hook protein, FlgE DM57_1984 ENOG4108KPB Flagellar basal-body rod protein FlgF DM57_1985 ENOG4105CGA flagellar basal-body rod protein FlgG DM57_1986 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DM57_1987 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) DM57_1988 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DM57_1989 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) DM57_1990 ENOG4105E1Q flagellar hook-associated protein DM57_1991 ENOG4105DTJ flagellar hook-associated protein DM57_1992 ENOG4105C2W permease DM57_1997 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DM57_1999 ENOG4108Z9W Outer membrane porin DM57_2006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DM57_2007 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DM57_201 ENOG41081YB ApbE family DM57_2017 ENOG4108VWS Yaeq family DM57_2019 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DM57_2022 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DM57_2025 ENOG4105EJC lysr family transcriptional regulator DM57_2026 ENOG4108HM4 ABC transporter DM57_2027 ENOG4105DGU Histone deacetylase DM57_2030 ENOG4105ED4 portal protein DM57_2039 ENOG4105C5I Dehydrogenase DM57_204 ENOG4105CIG ABC transporter DM57_2040 ENOG4105CC0 LysR family Transcriptional regulator DM57_2041 ENOG4105C9U ATP-dependent DNA helicase RecQ DM57_2043 ENOG4105C79 DNA protecting protein DprA DM57_2045 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DM57_2046 ENOG4108NIW Leucine export protein LeuE DM57_2048 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DM57_205 ENOG4108T0W nitrous oxide maturation protein NosY DM57_2050 ENOG4105ES5 Histidine kinase DM57_2051 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_2058 ENOG4105CNI cell division protein FtsW DM57_2059 ENOG4105CJN penicillin-binding protein DM57_2062 ENOG4105DFF Rod shape-determining protein mreb DM57_2066 ENOG4105CSR polyphosphate kinase 2 DM57_2067 ENOG4105CGK Exodeoxyribonuclease III DM57_2072 ENOG4105ETT transcriptional Regulator, LysR family DM57_2073 ENOG4108Z43 UPF0250 protein DM57_2074 ENOG4105F0I Aminotransferase DM57_2075 ENOG4105DZ1 carboxypeptidase DM57_2081 ENOG4105DHJ ABC, transporter DM57_2083 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic DM57_2085 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase DM57_2086 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) DM57_2088 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) DM57_2094 ENOG4105CGU Enoyl-CoA hydratase DM57_2099 ENOG4105C3R Methionine synthase DM57_210 ENOG4105HEE Binding Domain protein DM57_2100 ENOG4105C3R Methionine synthase DM57_2106 ENOG4105EMU Dehydrogenase DM57_2107 ENOG4105CHR reductase DM57_211 ENOG4105EGS Mechanosensitive ion channel DM57_2110 ENOG4105DEF Extracellular solute-binding protein, family 5 DM57_2111 ENOG4105C5H ABC transporter DM57_2114 ENOG41077A9 carbonic anhydrase DM57_2115 ENOG4105CHU acetyl-coa acetyltransferase DM57_2117 ENOG4105K5B UPF0225 protein DM57_2123 ENOG4106N3A copper homeostasis protein cutc DM57_2126 ENOG4105G6Z alkaline phosphatase DM57_2131 ENOG4108Z9W Outer membrane porin DM57_2133 ENOG4105DHU Bile acid DM57_2134 ENOG4105C8Q Methyl-accepting chemotaxis DM57_2135 ENOG4105ETE Transcriptional regulator (LacI family DM57_2137 ENOG4105D7K pfkb domain protein DM57_2145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DM57_2148 ENOG4108IJF Heavy metal efflux pump, CzcA DM57_2149 ENOG4105EP1 Efflux transporter rnd family, mfp subunit DM57_2153 ENOG4105HA9 of methanol dehydrogenase type DM57_2154 ENOG4108V0P LemA family DM57_216 ENOG4105D7N magnesium and cobalt transport protein CorA DM57_2169 ENOG4105CMM transposase DM57_2180 ENOG4105D9P serine threonine protein kinase DM57_2184 ENOG4105MP9 class II Aldolase DM57_2185 ENOG4105BZU Histidine kinase DM57_2192 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_2198 ENOG410609C Acyl carrier protein DM57_2201 ENOG4105D3Q Sugar transferase DM57_2202 ENOG4105DAY polysaccharide export protein DM57_2203 ENOG4108TJN glycosyl transferase group 1 DM57_2209 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_2215 ENOG4105KME endoribonuclease L-psp DM57_2230 ENOG4108TIT dATP pyrophosphohydrolase DM57_2231 ENOG4105DZQ phospholipase D Transphosphatidylase DM57_2233 ENOG4105CSU acyl-Coa dehydrogenase DM57_2235 ENOG4105CHU acetyl-coa acetyltransferase DM57_2236 ENOG4105E39 Enoyl-CoA hydratase DM57_2237 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DM57_2239 ENOG4105NAU thioesterase Superfamily protein DM57_2240 ENOG4108JJ7 ABC transporter DM57_2241 ENOG4108S0S Nucleotidyl transferase DM57_2242 ENOG4105EHM Aminoglycoside phosphotransferase DM57_2243 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) DM57_2244 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DM57_2245 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DM57_2250 ENOG4105E9Q Acyl-transferase DM57_2251 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase DM57_2252 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DM57_2254 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DM57_2255 ENOG4108JU5 Magnesium and cobalt efflux protein DM57_2256 ENOG4108NH8 Cation transport protein DM57_2258 ENOG4105C9A Phoh family DM57_2260 ENOG4105EJC lysr family transcriptional regulator DM57_2261 ENOG4105F27 Major Facilitator DM57_2262 ENOG4108JCI Transcriptional regulator DM57_2264 ENOG4107YBY Hydrolase DM57_2267 ENOG4105CAQ asparagine synthetase DM57_2268 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DM57_2269 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DM57_2271 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) DM57_2272 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DM57_2273 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DM57_2276 ENOG4105E98 transcriptional regulator DeoR family DM57_2277 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DM57_2280 ENOG4105C1J atp-dependent rna helicase DM57_2284 ENOG4105CXK mandelate racemase muconate lactonizing DM57_2287 ENOG4105BZU Histidine kinase DM57_2289 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_2291 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor DM57_2297 ENOG4108YSG O-Antigen polymerase DM57_2298 ENOG4105KHS type IV fimbrial pilin protein DM57_2299 ENOG4108ZCF integral membrane protein DM57_2300 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DM57_2303 ENOG4108004 Modulates RecA activity (By similarity) DM57_2304 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) DM57_2306 ENOG4105DHQ Histidine kinase DM57_2307 ENOG4105CSH Transporter DM57_231 ENOG4105ETE Transcriptional regulator (LacI family DM57_2313 ENOG4105ERG peptidase m48, ste24p DM57_2315 ENOG4105DNZ Alpha Beta Hydrolase DM57_2317 ENOG4105XA0 heptosyltransferase ii DM57_2319 ENOG4105CM2 brancheD-chain amino acid aminotransferase DM57_2322 ENOG4105BZA Phosphoglycerate kinase DM57_2323 ENOG4105CA9 Pyruvate kinase DM57_2325 ENOG4105C8V SAICAR synthetase DM57_2326 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DM57_2327 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DM57_2328 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DM57_2333 ENOG4105XJC Two component transcriptional regulator (Winged helix family DM57_2335 ENOG4105C0H protease DM57_2340 ENOG4105C1P efflux transporter, rnd family, mfp subunit DM57_2341 ENOG4105BZS acriflavin resistance protein DM57_2342 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DM57_2349 ENOG4105ECQ AraC Family Transcriptional Regulator DM57_235 ENOG4105D7K pfkb domain protein DM57_2350 ENOG4107QPD alcohol dehydrogenase DM57_2351 ENOG4105C4W S-formylglutathione hydrolase DM57_2352 ENOG4105CC5 ABC transporter DM57_2353 ENOG4105DIK (ABC) transporter DM57_2355 ENOG4105MYN Zinc uptake regulation protein DM57_2356 ENOG4105CHR reductase DM57_2357 ENOG4107UEK pfkb domain protein DM57_2358 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of DM57_2360 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component DM57_2362 ENOG4107URF beta-phospho-glucomutase DM57_2363 ENOG4108IJ9 (ABC) transporter DM57_2365 ENOG4105CC0 LysR family Transcriptional regulator DM57_2366 ENOG4107S1E Beta-lactamase DM57_2368 ENOG4105DKT Transcriptional regulator DM57_2369 ENOG4105CMG Carbohydrate kinase DM57_2372 ENOG4105DDW LysR family Transcriptional regulator DM57_2373 ENOG4105FP9 thiamine pyrophosphate DM57_2375 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DM57_2376 ENOG4105D2S major facilitator superfamily DM57_238 ENOG4105DUM transcriptional regulator, lysR family DM57_2381 ENOG4105F7P transcriptional regulator AsnC family DM57_2382 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DM57_2384 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase DM57_2386 ENOG4105CUZ uba thif-type nad fad binding protein DM57_2388 ENOG4105EUB pirin domain protein DM57_2389 ENOG4108594 Permease of the drug metabolite transporter DM57_239 ENOG4105HMI Membrane DM57_2390 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DM57_2391 ENOG4105K8N protein family UPF0079, ATPase DM57_2392 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DM57_2394 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DM57_2395 ENOG4105CEY Amp-dependent synthetase and ligase DM57_2396 ENOG4108Z66 YbaK ebsC protein DM57_2397 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DM57_2399 ENOG4105D4A Cell wall formation (By similarity) DM57_2400 ENOG4105DBV ornithine carbamoyltransferase DM57_2403 ENOG4105CJR Integral membrane protein (MviN DM57_2407 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DM57_241 ENOG4108IG5 Transcriptional regulator DM57_2412 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_2413 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DM57_2415 ENOG4105CMS peptidase U62, modulator of DNA gyrase DM57_2416 ENOG4105N42 UPF0307 protein DM57_2417 ENOG4108RIR Molybdenum cofactor biosynthesis protein DM57_2419 ENOG4105D0M Protease HtpX homolog DM57_2422 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DM57_243 ENOG4105BZS acriflavin resistance protein DM57_2434 ENOG4105EW9 transcriptional regulator AsnC family DM57_2438 ENOG4105C10 Electron transfer flavoprotein DM57_2439 ENOG4105BZJ Electron transfer flavoprotein DM57_2440 ENOG4105D01 (LipO)protein DM57_2441 ENOG4108UMI ABC transporter, permease DM57_2442 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DM57_2443 ENOG4105E5G Alpha beta hydrolase fold DM57_2445 ENOG4105CVE Lytic murein transglycosylase DM57_2446 ENOG4105C6T cysteine synthase DM57_245 ENOG4107TXC Transcriptional regulator DM57_2450 ENOG4105C6Y Udp-glucose 6-dehydrogenase DM57_2451 ENOG4105CFV Tetratricopeptide repeat protein DM57_2455 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DM57_2457 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DM57_2459 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DM57_2461 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DM57_2462 ENOG4105UYK outer membrane protein a DM57_2463 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) DM57_2464 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DM57_2468 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DM57_2470 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DM57_2473 ENOG4108JB9 formate dehydrogenase DM57_2477 ENOG4105CSH Transporter DM57_2478 ENOG4108Z86 Glutamine amidotransferase DM57_2479 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DM57_2480 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) DM57_2482 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DM57_2483 ENOG4105C7N Xanthine uracil vitamin C permease DM57_2484 ENOG4107QUY Guanine deaminase DM57_2487 ENOG4105CD8 aminopeptidase N DM57_2489 ENOG4105DZ2 Transcriptional regulator DM57_249 ENOG4105HDK L-asparaginase DM57_2498 ENOG4105CHB tonB-dependent Receptor DM57_2505 ENOG4105DFP Integrase DM57_2509 ENOG4108R99 pseudouridine synthase DM57_2516 ENOG4108ZHR arsR family transcriptional regulator DM57_2517 ENOG4105NAU thioesterase Superfamily protein DM57_2521 ENOG4107QI1 Mate efflux family protein DM57_2522 ENOG4105WQ3 Rna-binding protein DM57_2525 ENOG4108RH0 Crea protein DM57_2528 ENOG4108Z4U Ferredoxin DM57_2529 ENOG4107RH7 Nicotinate phosphoribosyltransferase DM57_253 ENOG4105CPK Glycosyl transferase (Group 1 DM57_2532 ENOG4105C5I Dehydrogenase DM57_2533 ENOG4107QSV RmuC domain protein DM57_2536 ENOG4105CVM Molybdenum cofactor synthesis domain protein DM57_2538 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DM57_2539 ENOG4105C03 ribonuclease DM57_254 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) DM57_2540 ENOG4105EI2 Pseudouridine synthase DM57_2544 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DM57_2545 ENOG4108UHJ MAF-like protein DM57_2546 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein DM57_2550 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DM57_2551 ENOG4105CHR reductase DM57_2553 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DM57_2555 ENOG4105EMN RNA polymerase sigma factor DM57_2557 ENOG4105VQK sigma E regulatory protein, MucB RseB DM57_2558 ENOG4105C0H protease DM57_2561 ENOG4105C3F Signal peptidase i DM57_2562 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DM57_2563 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DM57_2564 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) DM57_2565 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DM57_2567 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) DM57_2568 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_2572 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DM57_2577 ENOG4105CC0 LysR family Transcriptional regulator DM57_2578 ENOG4105EUB pirin domain protein DM57_2579 ENOG4107YB6 acetyltransferase, (GNAT) family DM57_258 ENOG4105F8V Hydrolase, tatD family DM57_2583 ENOG4108K4C ec 3.1.3.12 DM57_2584 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase DM57_2585 ENOG4105BZ1 (ABC) transporter DM57_2586 ENOG4105CPK Glycosyl transferase (Group 1 DM57_2588 ENOG4105MWK D-amino acid dehydrogenase, small subunit DM57_2589 ENOG4105CP9 extracellular ligand-binding receptor DM57_259 ENOG4107TCE N-acetyltransferase DM57_2594 ENOG410901P UPF0249 protein DM57_2597 ENOG4105DEN Luciferase family DM57_2599 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) DM57_260 ENOG4107QRG dna polymerase iii DM57_2603 ENOG4106YG3 ABC transporter DM57_2604 ENOG4108JEH abc transporter atp-binding protein DM57_2605 ENOG4105ECQ AraC Family Transcriptional Regulator DM57_2606 ENOG4105C8Y Acetylornithine aminotransferase DM57_2607 ENOG4108T2Z Arginine DM57_2609 ENOG4105C26 Dehydrogenase DM57_2611 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) DM57_2613 ENOG4105E89 ABC transporter DM57_2615 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DM57_262 ENOG4105HHA aminodeoxychorismate lyase DM57_2623 ENOG4105VG1 fes assembly suf system protein DM57_2624 ENOG4108UNV SUF system FeS assembly protein, NifU family DM57_2625 ENOG4105C9B Cysteine desulfurase DM57_2627 ENOG4105C3K feS assembly ATPase SufC DM57_263 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DM57_2630 ENOG4105C8Q Methyl-accepting chemotaxis DM57_2631 ENOG4105D4P Coproporphyrinogen iii oxidase DM57_2632 ENOG4105FQT DM57_2633 ENOG4105EYW Ion transport protein DM57_2635 ENOG4105CFP Peptidase U32 DM57_2636 ENOG4106RZ4 Peptidase U32 DM57_2637 ENOG4105XPQ lipid carrier protein DM57_2644 ENOG4105VG1 fes assembly suf system protein DM57_2645 ENOG4105DSQ Nitric oxide reductase DM57_2647 ENOG4105CVP deoxyribo-dipyrimidine photolyase DM57_2648 ENOG4108EJ0 Catalyzes the synthesis of activated sulfate (By similarity) DM57_2654 ENOG4105CGP Urocanate hydratase DM57_2656 ENOG4105CI2 imidazolone-5-propionate hydrolase DM57_2657 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) DM57_2659 ENOG4108Z86 Glutamine amidotransferase DM57_2660 ENOG4105CFQ glutamine synthetase DM57_2665 ENOG4107R11 Transcriptional regulator DM57_267 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DM57_2670 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) DM57_2671 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DM57_2674 ENOG4108M8S permease YjgP YjgQ family protein DM57_2676 ENOG4105MYG DNA polymerase iii, chi subunit DM57_2678 ENOG4105W2Z cytochrome C, class I DM57_2681 ENOG4106NZI LysR family Transcriptional regulator DM57_2685 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) DM57_2687 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) DM57_2688 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) DM57_2689 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) DM57_2690 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DM57_2691 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) DM57_2694 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DM57_2695 ENOG4105EFT decarboxylase DM57_2696 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) DM57_2697 ENOG4108YZT Adenosylcobinamide kinase DM57_2698 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DM57_27 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DM57_2700 ENOG4105D1F ATP-binding protein DM57_2703 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DM57_2705 ENOG4105CFU surface antigen DM57_2706 ENOG4105MA0 exported protein DM57_271 ENOG4105CHU acetyl-coa acetyltransferase DM57_2711 ENOG4105D1F ATP-binding protein DM57_2714 ENOG4105CXN decarboxylase DM57_2716 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 DM57_272 ENOG4108RWI nicotinamidase DM57_2723 ENOG4105F2W methyltransferase DM57_2727 ENOG41076E6 Uroporphyrinogen-III Synthase DM57_2729 ENOG4105CSP Major Facilitator Superfamily DM57_273 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DM57_2732 ENOG4105F0N pyrophosphate phospho-hydrolase DM57_2735 ENOG4105C4K Nad synthetase DM57_2736 ENOG4108YZA Nitrogen regulatory protein pii DM57_2737 ENOG4108Z9W Outer membrane porin DM57_2738 ENOG4108JEH abc transporter atp-binding protein DM57_2739 ENOG4106YG3 ABC transporter DM57_274 ENOG4105CEY Amp-dependent synthetase and ligase DM57_2740 ENOG4105DSP amino acid AbC transporter DM57_2741 ENOG4105E89 ABC transporter DM57_2745 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DM57_2746 ENOG4105E0F Histidine kinase DM57_2748 ENOG4105F38 ABC transporter, permease DM57_2754 ENOG41061WM D-Alanyl-D-Alanine DM57_2759 ENOG4108V1U phospholipid-binding protein DM57_2760 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_2763 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase DM57_2770 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) DM57_2771 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) DM57_2772 ENOG4105FDR Membrane DM57_2773 ENOG4105EQ0 Major Facilitator superfamily DM57_2778 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DM57_2779 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component DM57_2781 ENOG4108I5D sulfate abc transporter DM57_2782 ENOG4107QKW extracellular solute-binding protein family 1 DM57_2783 ENOG4105ETE Transcriptional regulator (LacI family DM57_2787 ENOG4105BZU Histidine kinase DM57_279 ENOG4107TF3 peptidylprolyl cis-trans isomerase DM57_2792 ENOG4105F7P transcriptional regulator AsnC family DM57_2793 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DM57_2805 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DM57_2809 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) DM57_281 ENOG4108ETH Formylglycinamide ribotide synthetase DM57_2810 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) DM57_2816 ENOG4108459 Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) DM57_2819 ENOG4105R5N Phosphoribosyl-dephospho-CoA transferase DM57_282 ENOG4105MWK D-amino acid dehydrogenase, small subunit DM57_2820 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase DM57_2828 ENOG4105CSH Transporter DM57_283 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DM57_2830 ENOG4107RZZ dna polymerase iii epsilon subunit DM57_2831 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DM57_2832 ENOG4105D1A Methyltransferase DM57_2833 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DM57_2834 ENOG4105E9H Lytic Murein transglycosylase DM57_2838 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DM57_2839 ENOG4108NIW Leucine export protein LeuE DM57_2840 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DM57_2841 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DM57_2843 ENOG4105HBR Rna-binding protein DM57_2845 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DM57_2846 ENOG4105EEI dihydropteroate synthase DM57_2848 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) DM57_2849 ENOG4105C8U phosphate abc transporter DM57_285 ENOG4108I0Y (ABC) transporter DM57_2850 ENOG4105E2Z phosphate ABC transporter (Permease DM57_2853 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DM57_2854 ENOG4105BZU Histidine kinase DM57_2855 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) DM57_2856 ENOG4105C9X ppx gppa phosphatase DM57_286 ENOG4108UJV acyl-CoA thioesterase i DM57_287 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DM57_2870 ENOG4107R73 Mate efflux family protein DM57_2874 ENOG4108K5P (LipO)protein DM57_2882 ENOG4105JQZ Methyltransferase DM57_2892 ENOG4105CG3 alpha amylase, catalytic region DM57_2893 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) DM57_2898 ENOG4108KB2 LysR family Transcriptional regulator DM57_2899 ENOG4105XJC Two component transcriptional regulator (Winged helix family DM57_29 ENOG4105CNN ABC, transporter DM57_2901 ENOG4105S66 prophage protein DM57_2906 ENOG4105RQ9 TPR repeat-containing protein DM57_2926 ENOG4107RGD Major Facilitator superfamily DM57_2927 ENOG4105DND Transcriptional regulator DM57_2934 ENOG4105BZU Histidine kinase DM57_2935 ENOG41068CG regulatoR DM57_2937 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_2938 ENOG4105CW7 secretion protein, HlyD family DM57_2939 ENOG4105RKW reductase (By DM57_294 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DM57_2941 ENOG4105CA0 peroxidase DM57_2946 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) DM57_2947 ENOG4105CX6 glutaminyL-tRNA synthetase DM57_2949 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DM57_2950 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DM57_2951 ENOG4105EGI Transcriptional regulator DM57_2959 ENOG4105E09 nadh pyrophosphatase DM57_2963 ENOG4105C32 Amino acid ABC transporter (Permease) DM57_2964 ENOG4105C0Z ABC transporter DM57_2965 ENOG4108IV0 ABC, transporter DM57_2966 ENOG4105DH8 myo-inositol catabolism DM57_2968 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DM57_2970 ENOG4105C2J ABC transporter DM57_2971 ENOG41062B0 ABC transporter, permease DM57_2973 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) DM57_2975 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DM57_2976 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DM57_2978 ENOG4108KXV response regulator DM57_298 ENOG4105BZW Glycerate kinase DM57_2980 ENOG4105BZU Histidine kinase DM57_2982 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DM57_2983 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DM57_2984 ENOG4105C4R Atp-dependent dna helicase DM57_2985 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DM57_2986 ENOG4105EU0 Major facilitator Superfamily DM57_2987 ENOG4105C8Q Methyl-accepting chemotaxis DM57_299 ENOG4105NTK Transcriptional repressor Mpra DM57_2992 ENOG4105CR8 Transcriptional regulator DM57_2995 ENOG4105CQB FAD linked oxidase domain protein DM57_2997 ENOG4105CS1 NAD(P)H quinone oxidoreductase DM57_2998 ENOG4107S2Z UPF0761 membrane protein DM57_30 ENOG4105CPQ Dehydrogenase DM57_300 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DM57_3001 ENOG4107S74 Lysophospholipid transporter LplT DM57_3008 ENOG4105EMN RNA polymerase sigma factor DM57_3014 ENOG4105CDU Replicative dna helicase DM57_3016 ENOG4107QXV Phosphate transporter DM57_3017 ENOG4105K4H Nlp p60 protein DM57_3018 ENOG4108IAB Phoh family DM57_3019 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DM57_3020 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) DM57_3023 ENOG4105CKK Glycosyl transferase, family 2 DM57_3024 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DM57_3026 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) DM57_3029 ENOG4105D6E homoserine dehydrogenase DM57_3031 ENOG4105CVM Molybdenum cofactor synthesis domain protein DM57_3032 ENOG4105M00 molybdopterin converting factor, subunit 1 DM57_3033 ENOG4108ZAF Molybdopterin DM57_3034 ENOG4105VIG Sec-independent protein translocase protein TatC DM57_3036 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DM57_304 ENOG4105DGU Histone deacetylase DM57_3041 ENOG4107QI1 Mate efflux family protein DM57_3045 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_3046 ENOG4108Z6Z Transcriptional regulator DM57_3047 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DM57_3048 ENOG4105K63 Thioredoxin DM57_3049 ENOG4107QMP dna polymerase iii subunits gamma and tau DM57_3050 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DM57_3052 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DM57_3055 ENOG4108K5P (LipO)protein DM57_3056 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DM57_3059 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DM57_3060 ENOG4108MN8 Membrane DM57_3064 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DM57_3067 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DM57_3070 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DM57_3071 ENOG4107QJR hflk protein DM57_3072 ENOG4105EPW hflc protein DM57_3076 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) DM57_3078 ENOG4105BZM domain protein DM57_3081 ENOG4105DVT helicase DM57_3083 ENOG4105C34 Pseudouridine synthase DM57_3084 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DM57_3085 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class DM57_3086 ENOG4105CHU acetyl-coa acetyltransferase DM57_3087 ENOG4105CHR reductase DM57_309 ENOG4105FE1 phytoene synthase DM57_3091 ENOG4105CHU acetyl-coa acetyltransferase DM57_3093 ENOG4105C28 cystathionine DM57_3094 ENOG4105EAC phosphoserine phosphatase DM57_3097 ENOG4108JJB ABC transporter DM57_3098 ENOG41066T0 asmA family DM57_3099 ENOG4105C5H ABC transporter DM57_31 ENOG4105CMG Carbohydrate kinase DM57_3106 ENOG4107RUE extracellular solute-binding protein family 1 DM57_3107 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DM57_3108 ENOG4105F38 ABC transporter, permease DM57_3109 ENOG4105D38 putrescine abc transporter DM57_3124 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_3129 ENOG4105CEY Amp-dependent synthetase and ligase DM57_313 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DM57_3131 ENOG4105JHE Major Facilitator Superfamily DM57_3132 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DM57_3137 ENOG4105C8Q Methyl-accepting chemotaxis DM57_314 ENOG4105E0F Histidine kinase DM57_3141 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DM57_3142 ENOG4105C2N RNA methyltransferase TrmH family group 3 DM57_3143 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DM57_3145 ENOG4108PVQ transcriptional regulator DM57_3146 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DM57_3149 ENOG4105E5Q amino acid AbC transporter DM57_3150 ENOG4105EAB amino acid AbC transporter DM57_3154 ENOG4105E09 nadh pyrophosphatase DM57_3156 ENOG41090KN UPF0303 protein DM57_316 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DM57_3162 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DM57_3172 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DM57_3173 ENOG4105CK2 sodium dicarboxylate symporter DM57_3174 ENOG4107YPT transcriptional regulator DM57_3176 ENOG4105CPC Aldo Keto reductase DM57_3177 ENOG4107S21 permease DM57_3187 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DM57_3188 ENOG4108I5D sulfate abc transporter DM57_319 ENOG4108JA2 transcriptioN-repair coupling factor DM57_3190 ENOG4108IJ6 ABC transporter DM57_3191 ENOG4107R11 Transcriptional regulator DM57_3195 ENOG4105CYN Serine protein kinase DM57_3196 ENOG4106AKX UPF0229 protein DM57_3197 ENOG4105ED1 spovr family DM57_3198 ENOG4105CSH Transporter DM57_32 ENOG4105CHR reductase DM57_3202 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DM57_321 ENOG4105CWC Acetylornithine deacetylase DM57_324 ENOG4108JQC penicillin-binding protein 1A DM57_336 ENOG4105DHG Allantoate amidinohydrolase DM57_337 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) DM57_340 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DM57_343 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DM57_344 ENOG4108Z6B deaminase DM57_345 ENOG4105VTS DnaJ-like, subfamily C DM57_3475 ENOG4108ZG0 Ompa motb domain protein DM57_352 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DM57_356 ENOG4105DXC membrane DM57_358 ENOG4108Z1B Cyclase dehydrase DM57_360 ENOG4107QX8 SPFH domain, Band 7 family protein DM57_362 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DM57_369 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DM57_37 ENOG4105E0A ABC, transporter DM57_374 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DM57_375 ENOG4105DZP Membrane-associated zinc metalloprotease DM57_377 ENOG4105KNE Phosphatidate cytidylyltransferase DM57_378 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DM57_38 ENOG4105S6R Iron-hydroxamate transporter permease subunit DM57_383 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DM57_385 ENOG4105FE9 pseudouridine synthase DM57_386 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DM57_393 ENOG4105KUZ arsenate reductase DM57_395 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) DM57_398 ENOG4105C5H ABC transporter DM57_3993 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_40 ENOG4105J76 Periplasmic binding protein DM57_400 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DM57_4009 ENOG4107RGD Major Facilitator superfamily DM57_402 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) DM57_403 ENOG4105DWF phosphomethylpyrimidine kinase DM57_4037 ENOG4108JQ6 ABC transporter DM57_407 ENOG41072GX Peptidase M22 Glycoprotease DM57_409 ENOG4105C1J atp-dependent rna helicase DM57_413 ENOG41068KF Universal stress protein DM57_4134 ENOG4107T8P acyl-Coa dehydrogenase DM57_414 ENOG4105EJC lysr family transcriptional regulator DM57_4146 ENOG4105R1U AraC Family Transcriptional Regulator DM57_416 ENOG4107QP3 malate synthase g DM57_419 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) DM57_42 ENOG4105IBP Cyclic peptide transporter DM57_425 ENOG4105D78 K07001 NTE family protein DM57_4256 ENOG4108Z9W Outer membrane porin DM57_426 ENOG4105K4H Nlp p60 protein DM57_427 ENOG4108JQ5 ABC transporter DM57_428 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component DM57_429 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component DM57_431 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DM57_433 ENOG4108J2R molybdopterin oxidoreductase DM57_434 ENOG4105DP0 ferredoxin-NADP reductase DM57_435 ENOG4108Z4U Ferredoxin DM57_438 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DM57_441 ENOG410880H cysteine synthase DM57_445 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DM57_446 ENOG4105EXC Acyl-transferase DM57_448 ENOG4108IUS Transketolase DM57_449 ENOG4105CV1 Transketolase (EC 2.2.1.1) DM57_453 ENOG4105E2B Taurine dioxygenase DM57_459 ENOG4105CEY Amp-dependent synthetase and ligase DM57_46 ENOG4105E0K tonB-dependent siderophore receptor DM57_460 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) DM57_462 ENOG4105BZS acriflavin resistance protein DM57_468 ENOG4105CFH Aspartokinase DM57_469 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DM57_47 ENOG4108V3E phosphoribosylglycinamide formyltransferase DM57_474 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DM57_476 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) DM57_477 ENOG4105D7W serine acetyltransferase DM57_479 ENOG4105ECY inositol monophosphatase DM57_48 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) DM57_485 ENOG4105EZE Cupin 4 family protein DM57_486 ENOG4105CY0 Metallo-Beta-Lactamase DM57_487 ENOG4105GJM (LipO)protein DM57_488 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DM57_49 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase DM57_490 ENOG4105C31 Tryptophanyl-tRNA synthetase DM57_491 ENOG4108Z4T Peptidase M50 DM57_492 ENOG4107RTD sua5 ycio yrdc ywlc family protein DM57_4923 ENOG41061H0 Monooxygenase DM57_493 ENOG4105DB7 PHP domain protein DM57_494 ENOG4105D74 hydrolase DM57_495 ENOG4105ED9 Protein of unknown function (DUF455) DM57_496 ENOG4108Z0R Transferase DM57_497 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DM57_499 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DM57_504 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 DM57_505 ENOG4105EYA deoxyribonuclease DM57_506 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DM57_509 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DM57_510 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DM57_513 ENOG4105WVQ Fe-S assembly protein IscX DM57_514 ENOG4108ZIT Ferredoxin, 2FE-2S DM57_516 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) DM57_517 ENOG4108Z4V iron-sulfur cluster assembly DM57_518 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins DM57_519 ENOG4105C3J Cysteine desulfurase DM57_52 ENOG4107QRP cobalamin biosynthesis protein CobW DM57_520 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family DM57_521 ENOG4105KJF protein tyrosine phosphatase DM57_523 ENOG4107QR9 Iron-sulfur cluster binding protein DM57_525 ENOG41069M3 Transcriptional regulator DM57_529 ENOG4108WFY phasin family DM57_53 ENOG4105CTK cobaltochelatase, cobn subunit DM57_530 ENOG41061WM D-Alanyl-D-Alanine DM57_533 ENOG4107QN2 dihydrolipoyl dehydrogenase DM57_534 ENOG4107QSN dihydrolipoamide acetyltransferase DM57_535 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DM57_536 ENOG4105BZU Histidine kinase DM57_537 ENOG4108ZXC Two component transcriptional regulator, luxr family DM57_539 ENOG4105DGW oligopeptidase A DM57_543 ENOG4105DQQ Major facilitator superfamily MFS_1 DM57_544 ENOG4105CRU nitrate reductase, alpha subunit DM57_545 ENOG4108IUE nitrate reductase beta subunit DM57_546 ENOG4108NZN Respiratory nitrate reductase 2 delta chain DM57_547 ENOG4105D0D Nitrate reductase 2, gamma subunit DM57_548 ENOG4105BZU Histidine kinase DM57_549 ENOG4105WH1 Two component transcriptional regulator luxr family DM57_552 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DM57_553 ENOG4105CUX Signal transduction histidine kinase DM57_554 ENOG4105C5F glutamine synthetase DM57_556 ENOG4107TH8 cina domain protein DM57_56 ENOG4106CJB Phospholipase Carboxylesterase DM57_562 ENOG4108EKC n-acetylglutamate synthase DM57_564 ENOG4105CSH Transporter DM57_566 ENOG4105CSU acyl-Coa dehydrogenase DM57_567 ENOG4107RSM transcriptional regulator DM57_577 ENOG4108YZN class I peptide chain release factor DM57_578 ENOG4107QYX exodeoxyribonuclease v alpha DM57_579 ENOG4107QKA exodeoxyribonuclease V beta DM57_58 ENOG4108NNZ chitinase DM57_580 ENOG4105DSY exodeoxyribonuclease V, gamma DM57_581 ENOG4105EM2 membrane DM57_582 ENOG4105C85 amino acid DM57_585 ENOG4108I5D sulfate abc transporter DM57_586 ENOG4108UCS ABC, transporter DM57_587 ENOG4108XM1 transcriptional regulator AsnC family DM57_590 ENOG4108Z40 Transcriptional regulator DM57_60 ENOG4105DVK Precorrin-2 c20-methyltransferase DM57_602 ENOG4105D1Q UPF0246 protein DM57_604 ENOG4105CHM Aminotransferase DM57_606 ENOG4108UKI Enoyl-CoA hydratase DM57_607 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DM57_609 ENOG4105C1G acyl-Coa dehydrogenase DM57_61 ENOG41081F0 Precorrin-8x methylmutase DM57_613 ENOG4105DXM phenylacetic acid degradation protein DM57_614 ENOG4105C1G acyl-Coa dehydrogenase DM57_615 ENOG4105CC9 acyl-Coa dehydrogenase DM57_619 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) DM57_62 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DM57_620 ENOG4105C8S subunit m DM57_623 ENOG4105DF2 NADH dehydrogenase subunit j DM57_625 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) DM57_626 ENOG4108IEH NADH dehydrogenase subunit g DM57_628 ENOG4105GKE subunit e DM57_63 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase DM57_634 ENOG4107EJC Preprotein translocase subunit SecG DM57_635 ENOG4105CP7 Triose-phosphate isomerase DM57_639 ENOG4105ES9 amino acid DM57_64 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) DM57_641 ENOG41077A9 carbonic anhydrase DM57_642 ENOG4105CHH sulfate transporter DM57_646 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DM57_649 ENOG4108ZP8 Acetolactate synthase small subunit DM57_650 ENOG4105C7K acetolactate synthase DM57_658 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) DM57_659 ENOG41080IJ Diacylglycerol kinase DM57_66 ENOG4105CIA precorrin-4 C(11)-methyltransferase DM57_660 ENOG41062JF Transcriptional regulator DM57_661 ENOG4108URH decarboxylase DM57_662 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DM57_663 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) DM57_664 ENOG4105CSH Transporter DM57_666 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DM57_668 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DM57_67 ENOG4105F32 YngK protein DM57_673 ENOG4105KPY Small multidrug resistance protein DM57_675 ENOG4105EEX Two component transcriptional regulator (Winged helix family DM57_676 ENOG4105C08 Histidine kinase DM57_679 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DM57_68 ENOG4105DJ2 Major Facilitator Superfamily DM57_682 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DM57_685 ENOG41090TK Short-chain dehydrogenase reductase Sdr DM57_688 ENOG4105C12 Phosphoribosylglycinamide synthetase DM57_69 ENOG4108ZT1 Transcriptional regulator DM57_691 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) DM57_693 ENOG4108Z03 MAF-like protein DM57_694 ENOG4105C03 ribonuclease DM57_695 ENOG4105C2W permease DM57_7 ENOG4105EAB amino acid AbC transporter DM57_70 ENOG4105CP9 extracellular ligand-binding receptor DM57_701 ENOG4108KPJ rna polymerase sigma factor DM57_702 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DM57_707 ENOG4106WTF Glycosyl transferase, family 2 DM57_708 ENOG4105DKP glycosyl transferase, family 9 DM57_709 ENOG4107XU6 Glycosyl transferase (Group 1 DM57_713 ENOG4105BZ1 (ABC) transporter DM57_716 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DM57_717 ENOG4105C1J atp-dependent rna helicase DM57_718 ENOG41069B0 Membrane-bound lysozyme-inhibitor of c-type lysozyme DM57_72 ENOG4105CYM Glutathione S-transferase DM57_725 ENOG4105BZP glycoside hydrolase 15-related DM57_727 ENOG4108W9H Tetr family transcriptional regulator DM57_728 ENOG4108R3D Electron transport complex DM57_729 ENOG4105CSM endonuclease III DM57_73 ENOG410642W LysR family Transcriptional regulator DM57_733 ENOG41090Y2 cytochrome C DM57_734 ENOG4106RE7 Cytochrome DM57_737 ENOG4105DKK Benzoate DM57_739 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase DM57_742 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DM57_746 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DM57_748 ENOG4105T38 integral membrane protein DM57_749 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DM57_753 ENOG4108S8N class II Aldolase DM57_754 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DM57_755 ENOG4108RPX mosc domain containing protein DM57_756 ENOG4105D74 hydrolase DM57_758 ENOG4105HEI LysR family (Transcriptional regulator DM57_76 ENOG4105C5B carbamate kinase DM57_763 ENOG4108EX3 reductase DM57_764 ENOG4105C8Y Acetylornithine aminotransferase DM57_765 ENOG4108R6G acetyltransferase DM57_767 ENOG4108IV0 ABC, transporter DM57_768 ENOG4105C0Z ABC transporter DM57_769 ENOG4105CF8 branched-chain amino acid ABC transporter, permease DM57_77 ENOG4105DBV ornithine carbamoyltransferase DM57_770 ENOG4105C32 Amino acid ABC transporter (Permease) DM57_774 ENOG4105ESV Glycosyl transferase, family 4 DM57_78 ENOG4105CEU Arginine dihydrolase DM57_780 ENOG4105K64 Glycosyl transferase, family 2 DM57_788 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase DM57_79 ENOG4105D5Q Arginine ornithine antiporter DM57_793 ENOG4105CD3 dihydroorotase DM57_795 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DM57_797 ENOG4108UJU UPF0301 protein DM57_799 ENOG4105VCQ rubredoxin DM57_8 ENOG4105EZ7 amino acid ABC transporter DM57_804 ENOG4105KVH Transcriptional regulator DM57_805 ENOG4105CB2 alcohol dehydrogenase DM57_81 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component DM57_815 ENOG4105E82 cytochrome subunit of dehydrogenase DM57_816 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DM57_818 ENOG4107TSN permease DM57_820 ENOG4106BE1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity) DM57_825 ENOG4105EHG Permease protein DM57_828 ENOG4105E0A ABC, transporter DM57_829 ENOG4105E0K tonB-dependent siderophore receptor DM57_83 ENOG4108IJ8 ABC transporter DM57_832 ENOG4105C7W Xanthine dehydrogenase DM57_834 ENOG4105F9N Major Facilitator Superfamily DM57_835 ENOG4105DWP Membrane DM57_837 ENOG4105C5R Aminotransferase DM57_838 ENOG4105CBN LysR family transcriptional regulator DM57_84 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component DM57_840 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase DM57_841 ENOG4105F27 Major Facilitator DM57_845 ENOG4105D2S major facilitator superfamily DM57_847 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase DM57_85 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system DM57_852 ENOG4105C1G acyl-Coa dehydrogenase DM57_853 ENOG4105D3R alkyl hydroperoxide reductase DM57_863 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DM57_864 ENOG4105EMU Dehydrogenase DM57_865 ENOG4107YD3 Thioesterase DM57_866 ENOG4105E02 MotA TolQ exbB proton channel DM57_867 ENOG4105M8F Biopolymer transport protein exbD tolR DM57_869 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DM57_87 ENOG4105C0R drug resistance transporter emrb qaca subfamily DM57_870 ENOG4105KCK Peptidoglycan-associated lipoprotein DM57_876 ENOG4108RRZ Transcription elongation factor GreB DM57_879 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DM57_88 ENOG4105CEY Amp-dependent synthetase and ligase DM57_881 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DM57_882 ENOG4105DSJ YicC domain protein DM57_884 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DM57_885 ENOG4105CSA Coproporphyrinogen iii oxidase DM57_889 ENOG4105CSH Transporter DM57_891 ENOG4105D16 lipopolysaccharide heptosyltransferase i DM57_893 ENOG4105CMQ Chloride channel DM57_896 ENOG4107QMS site-determining protein DM57_9 ENOG4105E5Q amino acid AbC transporter DM57_90 ENOG4105C8Q Methyl-accepting chemotaxis DM57_903 ENOG4105D1H recombination factor protein RarA DM57_904 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) DM57_905 ENOG4105CNU cell division protein FtsK DM57_906 ENOG4105C3M thioredoxin reductase DM57_907 ENOG4105C98 muts2 protein DM57_908 ENOG4105EN6 Membrane DM57_909 ENOG4108IJ9 (ABC) transporter DM57_91 ENOG4108V3W Chemotaxis protein, CheW DM57_911 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component DM57_913 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DM57_914 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) DM57_916 ENOG4105EAB amino acid AbC transporter DM57_917 ENOG4105E5Q amino acid AbC transporter DM57_918 ENOG4105CDA abc transporter atp-binding protein DM57_921 ENOG4105C2C drug resistance transporter, Bcr CflA DM57_925 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DM57_927 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DM57_93 ENOG4108K01 transcriptional regulator DM57_930 ENOG4105CHM Aminotransferase DM57_932 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DM57_937 ENOG4108VIA integral membrane protein DM57_94 ENOG4108Z9W Outer membrane porin DM57_941 ENOG4105DMQ Methyltransferase DM57_944 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DM57_947 ENOG4105KRS Proteinase inhibitor DM57_948 ENOG4105D4P Coproporphyrinogen iii oxidase DM57_950 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DM57_952 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DM57_953 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein DM57_954 ENOG4105C32 Amino acid ABC transporter (Permease) DM57_958 ENOG4105C2J ABC transporter DM57_959 ENOG4108IV0 ABC, transporter DM57_96 ENOG41085A6 mbth domain-containing protein DM57_967 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase DM57_969 ENOG4105D16 lipopolysaccharide heptosyltransferase i DM57_974 ENOG4105CMR udp-glucose 4-epimerase DM57_979 ENOG4105JAB phenazine biosynthesis protein, phzf family DM57_980 ENOG4105BZU Histidine kinase DM57_983 ENOG4105CE7 Amidase, hydantoinase carbamoylase family DM57_984 ENOG4105CSH Transporter DM57_985 ENOG4105DND Transcriptional regulator DM57_987 ENOG4105HEI LysR family (Transcriptional regulator DM57_989 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DM57_99 ENOG4105CIH Imidazole acetol-phosphate transaminase DM57_990 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DM57_991 ENOG4105C5H ABC transporter DM57_993 ENOG4105VCQ rubredoxin DM57_996 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)