locus-tag	class	description
DM57_05080	COG0625	glutathione transferase activity
DM57_05100	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_05110	COG0671	phosphoesterase, PA-phosphatase related
DM57_05150	COG1032	radical SAM domain protein
DM57_05165	COG0583	DNA-binding transcription factor activity
DM57_05170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM57_05175	COG0589	response to stress
DM57_05215	COG1045	serine acetyltransferase
DM57_05220	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_05225	COG0302	gtp cyclohydrolase
DM57_05245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DM57_05250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DM57_05255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DM57_05260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM57_05315	COG1595	DNA-templated transcription, initiation
DM57_05320	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DM57_05345	COG2916	Histone family protein nucleoid-structuring protein H-NS
DM57_05350	COG0477	Major facilitator Superfamily
DM57_05455	COG0745	RESPONSE REGULATOR receiver
DM57_05455	COG3706	GGDEF domain
DM57_05465	COG0596	Alpha beta hydrolase
DM57_05495	COG2963	transposase activity
DM57_05505	COG0625	glutathione transferase activity
DM57_05520	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DM57_05525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DM57_05545	COG0295	cytidine deaminase activity
DM57_05550	COG2823	Periplasmic or secreted lipoprotein
DM57_05560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DM57_05565	COG0280	phosphate acetyltransferase
DM57_05570	COG3243	poly(R)-hydroxyalkanoic acid synthase
DM57_05580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DM57_05595	COG0356	it plays a direct role in the translocation of protons across the membrane
DM57_05605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM57_05605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM57_05635	COG0840	transmembrane signaling receptor activity
DM57_05640	COG0784	Response regulator, receiver
DM57_05640	COG4191	Histidine kinase
DM57_05645	COG0842	Transport permease protein
DM57_05650	COG0842	Transport permease protein
DM57_05650	COG1129	ABC transporter
DM57_05655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM57_05660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM57_05675	COG0589	response to stress
DM57_05690	COG1136	(ABC) transporter
DM57_05705	COG0840	transmembrane signaling receptor activity
DM57_05735	COG1611	Belongs to the LOG family
DM57_05765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM57_05770	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_05780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DM57_05810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DM57_05830	COG0456	acetyltransferase
DM57_05830	COG0454	-acetyltransferase
DM57_05840	COG0154	amidase activity
DM57_05845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_05895	COG3302	dmso reductase anchor subunit
DM57_05900	COG0437	4 iron, 4 sulfur cluster binding
DM57_05905	COG0243	molybdopterin cofactor binding
DM57_05920	COG3246	L-lysine catabolic process to acetate
DM57_05925	COG2175	clavaminate synthase activity
DM57_05955	COG0071	Belongs to the small heat shock protein (HSP20) family
DM57_05965	COG2239	Acts as a magnesium transporter
DM57_06005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM57_06040	COG0022	dehydrogenase e1 component
DM57_06065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM57_06080	COG2091	lysine biosynthetic process via aminoadipic acid
DM57_06085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM57_06090	COG2084	Dehydrogenase
DM57_06100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DM57_06105	COG0688	phosphatidylethanolamine metabolic process
DM57_06115	COG5265	(ABC) transporter
DM57_06125	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_06130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM57_06135	COG0859	PFAM glycosyl transferase family 9
DM57_06140	COG2192	nodulation
DM57_06165	COG2204	response regulator
DM57_06180	COG0784	Response regulator, receiver
DM57_06180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM57_06180	COG2198	Histidine kinase
DM57_06180	COG2205	protein histidine kinase activity
DM57_06190	COG0438	transferase activity, transferring glycosyl groups
DM57_06200	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_06220	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_06240	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DM57_06255	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DM57_06260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DM57_06275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM57_06335	COG2963	transposase activity
DM57_06340	COG0513	Belongs to the DEAD box helicase family
DM57_06355	COG1473	amidohydrolase
DM57_06360	COG0583	DNA-binding transcription factor activity
DM57_06400	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_06420	COG3537	Alpha-1,2-mannosidase
DM57_06440	COG0367	asparagine synthase
DM57_06535	COG3501	Rhs element vgr protein
DM57_06565	COG0583	DNA-binding transcription factor activity
DM57_06570	COG2249	NAD(P)H dehydrogenase (quinone) activity
DM57_06610	COG1984	allophanate hydrolase subunit 2
DM57_06625	COG0511	ligase activity, forming carbon-carbon bonds
DM57_06630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DM57_06660	COG0840	transmembrane signaling receptor activity
DM57_06715	COG0535	radical SAM domain protein
DM57_06720	COG0840	transmembrane signaling receptor activity
DM57_06745	COG1285	pathogenesis
DM57_06770	COG2217	Heavy metal translocating P-type atpase
DM57_06805	COG0346	lactoylglutathione lyase activity
DM57_06815	COG1562	ergosterol biosynthetic process
DM57_06825	COG0583	DNA-binding transcription factor activity
DM57_06835	COG1294	oxidase, subunit
DM57_06840	COG1271	oxidase subunit
DM57_06845	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
DM57_06860	COG2860	membrane
DM57_06865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DM57_06875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM57_06880	COG4558	Periplasmic binding protein
DM57_06885	COG3720	iron ion transport
DM57_06910	COG3842	ATPase activity
DM57_06915	COG1840	ABC-type Fe3 transport system, periplasmic component
DM57_06930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_06940	COG0698	ribose 5-phosphate isomerase
DM57_06945	COG1129	ABC transporter
DM57_06950	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM57_06955	COG1879	ABC-type sugar transport system periplasmic component
DM57_06960	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_06965	COG1063	alcohol dehydrogenase
DM57_06970	COG2376	Dihydroxyacetone kinase
DM57_07020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DM57_07055	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DM57_07065	COG2801	Transposase and inactivated derivatives
DM57_07075	COG3634	alkyl hydroperoxide reductase activity
DM57_07080	COG0450	alkyl hydroperoxide reductase
DM57_07090	COG0778	Nitroreductase
DM57_07100	COG2308	Evidence 4 Homologs of previously reported genes of
DM57_07125	COG1305	Transglutaminase-like
DM57_07145	COG4977	sequence-specific DNA binding
DM57_07155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DM57_07160	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
DM57_07160	COG0028	Belongs to the TPP enzyme family
DM57_07205	COG2963	transposase activity
DM57_07210	COG2831	hemolysin activation secretion protein
DM57_07215	COG3210	domain, Protein
DM57_07215	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
DM57_07215	COG3064	Membrane
DM57_07220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DM57_07245	COG2188	Transcriptional regulator
DM57_07250	COG2009	succinate dehydrogenase
DM57_07260	COG1053	succinate dehydrogenase
DM57_07265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DM57_07270	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
DM57_07275	COG0372	Belongs to the citrate synthase family
DM57_07295	COG2963	transposase activity
DM57_07320	COG1522	sequence-specific DNA binding
DM57_07350	COG0473	3-isopropylmalate dehydrogenase activity
DM57_07375	COG0135	phosphoribosylanthranilate isomerase activity
DM57_07380	COG0133	tryptophan synthase activity
DM57_07395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DM57_07400	COG0285	dihydrofolate synthase activity
DM57_07430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM57_07435	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DM57_07440	COG2755	lipolytic protein G-D-S-L family
DM57_07440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DM57_07455	COG0438	transferase activity, transferring glycosyl groups
DM57_07470	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DM57_07480	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DM57_07480	COG2755	lipolytic protein G-D-S-L family
DM57_07490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_07495	COG1295	ribonuclease BN
DM57_07505	COG3608	succinylglutamate desuccinylase aspartoacylase
DM57_07525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM57_07530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM57_07540	COG1126	abc transporter atp-binding protein
DM57_07555	COG0243	molybdopterin cofactor binding
DM57_07555	COG3383	formate dehydrogenase (NAD+) activity
DM57_07565	COG0437	4 iron, 4 sulfur cluster binding
DM57_07570	COG2864	formate dehydrogenase
DM57_07580	COG1921	L-seryl-tRNASec selenium transferase activity
DM57_07585	COG3276	selenocysteine insertion sequence binding
DM57_07605	COG0154	amidase activity
DM57_07675	COG4191	Histidine kinase
DM57_07685	COG2814	Major facilitator Superfamily
DM57_07705	COG0583	DNA-binding transcription factor activity
DM57_07715	COG2030	dehydratase
DM57_07720	COG0427	acetyl-CoA hydrolase
DM57_07725	COG0028	Belongs to the TPP enzyme family
DM57_07805	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM57_07810	COG4789	Type iii secretion
DM57_07830	COG4794	Type iii secretion
DM57_07860	COG2207	Transcriptional regulator
DM57_08000	COG3550	peptidyl-serine autophosphorylation
DM57_08015	COG1215	transferase activity, transferring glycosyl groups
DM57_08020	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DM57_08045	COG1215	transferase activity, transferring glycosyl groups
DM57_08050	COG2194	sulfuric ester hydrolase activity
DM57_08070	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DM57_08075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM57_08100	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_08110	COG0306	phosphate transporter
DM57_08125	COG1522	sequence-specific DNA binding
DM57_08130	COG1280	lysine exporter protein (LysE YggA)
DM57_08160	COG0477	Major facilitator Superfamily
DM57_08240	COG4789	Type iii secretion
DM57_08250	COG1157	protein secretion by the type III secretion system
DM57_08270	COG4790	Type iii secretion
DM57_08305	COG2916	Histone family protein nucleoid-structuring protein H-NS
DM57_08320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_08325	COG0741	lytic transglycosylase activity
DM57_08420	COG1309	transcriptional regulator
DM57_08425	COG1414	Transcriptional regulator
DM57_08430	COG0183	Belongs to the thiolase family
DM57_08440	COG0840	transmembrane signaling receptor activity
DM57_08470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DM57_08480	COG1288	antiporter activity
DM57_08485	COG1414	Transcriptional regulator
DM57_08515	COG0709	Synthesizes selenophosphate from selenide and ATP
DM57_08545	COG0583	DNA-binding transcription factor activity
DM57_08555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM57_08570	COG1301	dicarboxylic acid transport
DM57_08605	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_08610	COG0019	diaminopimelate decarboxylase activity
DM57_08625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM57_08625	COG3321	synthase
DM57_08625	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_08625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DM57_08625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_08660	COG2197	response regulator
DM57_08675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DM57_08680	COG2011	ABC-type metal ion transport system permease component
DM57_08700	COG2186	Transcriptional regulator
DM57_08705	COG0247	lactate metabolic process
DM57_08710	COG1139	Iron-sulfur cluster binding protein
DM57_08715	COG1556	Lactate utilization protein
DM57_08720	COG1620	l-lactate permease
DM57_08725	COG2259	Doxx family
DM57_08740	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DM57_08750	COG0531	amino acid
DM57_08760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM57_08770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM57_08805	COG2963	transposase activity
DM57_08830	COG1278	Cold shock
DM57_08850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM57_08865	COG4251	negative regulation of phosphorylation
DM57_08870	COG0784	Response regulator, receiver
DM57_08880	COG0477	Major facilitator Superfamily
DM57_08895	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DM57_08905	COG1309	transcriptional regulator
DM57_08910	COG2963	transposase activity
DM57_08945	COG1566	PFAM secretion protein HlyD family protein
DM57_08950	COG1505	serine-type exopeptidase activity
DM57_08960	COG1045	serine acetyltransferase
DM57_08970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM57_08975	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DM57_08980	COG3038	cytochrome b561
DM57_08990	COG0640	Transcriptional regulator
DM57_08995	COG2391	methyltransferase activity
DM57_09005	COG0456	acetyltransferase
DM57_09020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DM57_09025	COG1858	cytochrome C peroxidase
DM57_09040	COG2188	Transcriptional regulator
DM57_09090	COG0277	FAD linked oxidase domain protein
DM57_09095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM57_09105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DM57_09135	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DM57_09145	COG1446	asparaginase
DM57_09150	COG0747	negative chemotaxis
DM57_09155	COG0601	transmembrane transport
DM57_09160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM57_09175	COG3485	protocatechuate 3,4-dioxygenase
DM57_09180	COG3485	protocatechuate 3,4-dioxygenase
DM57_09185	COG0583	DNA-binding transcription factor activity
DM57_09205	COG2203	Gaf domain
DM57_09205	COG3706	GGDEF domain
DM57_09205	COG5001	Diguanylate cyclase
DM57_09205	COG4251	negative regulation of phosphorylation
DM57_09215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DM57_09235	COG0531	amino acid
DM57_09240	COG2963	transposase activity
DM57_09250	COG1201	RNA secondary structure unwinding
DM57_09285	COG2274	protein secretion by the type I secretion system
DM57_09305	COG2963	transposase activity
DM57_09340	COG1739	Uncharacterized protein family UPF0029
DM57_09350	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_09385	COG2963	transposase activity
DM57_09395	COG2066	Belongs to the glutaminase family
DM57_09405	COG0745	RESPONSE REGULATOR receiver
DM57_09410	COG2205	protein histidine kinase activity
DM57_09470	COG0642	Histidine kinase
DM57_09475	COG0745	RESPONSE REGULATOR receiver
DM57_09545	COG2963	transposase activity
DM57_09560	COG3214	Protein conserved in bacteria
DM57_09565	COG0477	Major facilitator Superfamily
DM57_09575	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
DM57_09585	COG1845	cytochrome c oxidase, subunit III
DM57_09625	COG2207	Transcriptional regulator
DM57_09650	COG2205	protein histidine kinase activity
DM57_09655	COG0745	RESPONSE REGULATOR receiver
DM57_09670	COG1846	Transcriptional regulator
DM57_09685	COG1012	belongs to the aldehyde dehydrogenase family
DM57_09690	COG3384	dioxygenase
DM57_09700	COG3971	2-oxopent-4-enoate hydratase activity
DM57_09720	COG3842	ATPase activity
DM57_09730	COG1840	ABC-type Fe3 transport system, periplasmic component
DM57_09740	COG0642	Histidine kinase
DM57_09745	COG3217	Mosc domain protein beta barrel domain protein
DM57_09745	COG0633	Ferredoxin
DM57_09750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_09765	COG1024	Enoyl-CoA hydratase
DM57_09780	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DM57_09785	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DM57_09805	COG2963	transposase activity
DM57_09820	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DM57_09825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DM57_09830	COG2271	Major facilitator Superfamily
DM57_09850	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM57_09865	COG1012	belongs to the aldehyde dehydrogenase family
DM57_09910	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DM57_09915	COG0667	Aldo Keto reductase
DM57_09920	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_09935	COG0556	nucleotide-excision repair
DM57_09945	COG4633	Protein conserved in bacteria
DM57_09960	COG3193	protein, possibly involved in utilization of glycolate and propanediol
DM57_09965	COG2963	transposase activity
DM57_09990	COG2963	transposase activity
DM57_10005	COG1309	transcriptional regulator
DM57_1002	COG2963	transposase activity
DM57_10020	COG1902	pentaerythritol trinitrate reductase activity
DM57_10030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DM57_10040	COG0628	permease
DM57_10050	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_1006	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DM57_1007	COG1047	Peptidyl-prolyl cis-trans
DM57_10080	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_10095	COG1538	Outer membrane efflux protein
DM57_1010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DM57_10100	COG1215	transferase activity, transferring glycosyl groups
DM57_1011	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM57_1015	COG3264	Mechanosensitive ion channel
DM57_1015	COG1511	domain protein
DM57_1016	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM57_1016	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DM57_10160	COG2963	transposase activity
DM57_1017	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DM57_1018	COG0196	riboflavin kinase activity
DM57_1019	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DM57_10190	COG0583	DNA-binding transcription factor activity
DM57_10200	COG0583	DNA-binding transcription factor activity
DM57_10230	COG1012	belongs to the aldehyde dehydrogenase family
DM57_10235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DM57_10240	COG0531	amino acid
DM57_1025	COG2963	transposase activity
DM57_10255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_10275	COG1902	pentaerythritol trinitrate reductase activity
DM57_1028	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DM57_10290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_10305	COG0516	GMP reductase activity
DM57_10305	COG0517	IMP dehydrogenase activity
DM57_1031	COG0656	L-ascorbic acid biosynthetic process
DM57_10310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM57_1032	COG2188	Transcriptional regulator
DM57_10330	COG2197	response regulator
DM57_10335	COG1285	pathogenesis
DM57_10340	COG1408	metallophosphoesterase
DM57_1035	COG2814	Major facilitator Superfamily
DM57_10355	COG1414	Transcriptional regulator
DM57_10360	COG2146	nitrite reductase [NAD(P)H] activity
DM57_10390	COG1414	Transcriptional regulator
DM57_10395	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_104	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_10400	COG0028	Belongs to the TPP enzyme family
DM57_10410	COG1012	belongs to the aldehyde dehydrogenase family
DM57_10425	COG0477	Major facilitator Superfamily
DM57_10450	COG0154	amidase activity
DM57_10455	COG1522	sequence-specific DNA binding
DM57_1047	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DM57_1049	COG1663	tetraacyldisaccharide 4'-kinase activity
DM57_10490	COG0492	ferredoxin-NADP+ reductase activity
DM57_10500	COG2963	transposase activity
DM57_10515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM57_1054	COG1278	Cold shock
DM57_10540	COG0840	transmembrane signaling receptor activity
DM57_10545	COG0840	transmembrane signaling receptor activity
DM57_1056	COG0542	response to heat
DM57_10570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DM57_1059	COG2963	transposase activity
DM57_10600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_1062	COG0156	8-amino-7-oxononanoate synthase activity
DM57_10625	COG0583	DNA-binding transcription factor activity
DM57_1063	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DM57_10645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM57_1065	COG1368	sulfuric ester hydrolase activity
DM57_10650	COG0601	transmembrane transport
DM57_10660	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DM57_1068	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM57_10685	COG3501	Rhs element vgr protein
DM57_10695	COG3209	COG3209 Rhs family protein
DM57_1070	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DM57_10725	COG2140	Oxalate decarboxylase
DM57_10730	COG1914	H( )-stimulated, divalent metal cation uptake system
DM57_10735	COG4682	membrane
DM57_10740	COG3781	membrane
DM57_10745	COG0243	molybdopterin cofactor binding
DM57_10750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM57_10770	COG1404	Belongs to the peptidase S8 family
DM57_10795	COG2259	Doxx family
DM57_10815	COG4215	(ABC) transporter
DM57_10820	COG4160	amino acid transport
DM57_10825	COG4598	ABC transporter
DM57_10865	COG3275	phosphorelay sensor kinase activity
DM57_10875	COG2963	transposase activity
DM57_10880	COG3279	Response regulator of the LytR AlgR family
DM57_10895	COG0500	methyltransferase
DM57_1090	COG0586	Pfam SNARE associated Golgi protein
DM57_10900	COG2207	Transcriptional regulator
DM57_1091	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DM57_10915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM57_10920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_10925	COG1024	Enoyl-CoA hydratase
DM57_10930	COG1024	Enoyl-CoA hydratase
DM57_10945	COG3425	synthase
DM57_1095	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DM57_10965	COG2070	2-Nitropropane dioxygenase
DM57_10965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DM57_1097	COG0617	tRNA 3'-terminal CCA addition
DM57_10970	COG0569	domain protein
DM57_10970	COG0475	glutathione-regulated potassium exporter activity
DM57_10975	COG3321	synthase
DM57_10975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_10975	COG0300	oxidoreductase activity
DM57_10975	COG4221	oxidoreductase activity
DM57_10980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_10980	COG3321	synthase
DM57_10980	COG0300	oxidoreductase activity
DM57_10980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_10980	COG4221	oxidoreductase activity
DM57_10980	COG3321	synthase
DM57_10980	COG4221	oxidoreductase activity
DM57_10980	COG0300	oxidoreductase activity
DM57_1099	COG1428	Deoxynucleoside kinase
DM57_10990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_10990	COG4221	oxidoreductase activity
DM57_10990	COG0300	oxidoreductase activity
DM57_10990	COG3321	synthase
DM57_11	COG1309	transcriptional regulator
DM57_1101	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DM57_11015	COG0583	DNA-binding transcription factor activity
DM57_11025	COG0387	Pfam Sodium calcium exchanger
DM57_11040	COG0179	Fumarylacetoacetate (FAA) hydrolase
DM57_11065	COG2353	YceI-like domain
DM57_11080	COG1595	DNA-templated transcription, initiation
DM57_11085	COG3712	iron ion homeostasis
DM57_1109	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DM57_11090	COG4774	siderophore transport
DM57_11095	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM57_111	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_1110	COG0497	DNA recombination
DM57_11100	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM57_1111	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DM57_1112	COG3164	Protein of unknown function
DM57_11120	COG2963	transposase activity
DM57_1113	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM57_11130	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DM57_11130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM57_11130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_11130	COG3321	synthase
DM57_1114	COG0312	modulator of DNA gyrase
DM57_11145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DM57_1115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DM57_11180	COG1979	alcohol dehydrogenase
DM57_11185	COG2130	NADP-dependent
DM57_11205	COG0583	DNA-binding transcription factor activity
DM57_1121	COG4977	sequence-specific DNA binding
DM57_1121	COG1917	Cupin 2, conserved barrel domain protein
DM57_1122	COG0625	glutathione transferase activity
DM57_11225	COG0477	Major facilitator Superfamily
DM57_1123	COG0625	glutathione transferase activity
DM57_11245	COG0302	gtp cyclohydrolase
DM57_1125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DM57_11250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM57_11250	COG1116	anion transmembrane transporter activity
DM57_11255	COG3707	response regulator
DM57_1127	COG0588	phosphoglycerate mutase activity
DM57_11270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM57_11275	COG2146	nitrite reductase [NAD(P)H] activity
DM57_11280	COG0243	molybdopterin cofactor binding
DM57_11305	COG1070	Carbohydrate kinase
DM57_11315	COG3842	ATPase activity
DM57_11320	COG1063	alcohol dehydrogenase
DM57_1134	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DM57_11345	COG2223	nitrite transmembrane transporter activity
DM57_1135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DM57_11350	COG1349	DNA-binding transcription factor activity
DM57_1136	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM57_1137	COG0006	proline dipeptidase activity
DM57_1138	COG0625	glutathione transferase activity
DM57_11390	COG4651	solute:proton antiporter activity
DM57_11390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DM57_11395	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_114	COG0583	DNA-binding transcription factor activity
DM57_1140	COG0069	glutamate synthase activity
DM57_11410	COG2963	transposase activity
DM57_1143	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DM57_11435	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DM57_1144	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
DM57_1145	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
DM57_11450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM57_11455	COG1538	Outer membrane efflux protein
DM57_11460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM57_11465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM57_1152	COG3008	intermembrane lipid transfer
DM57_1152	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DM57_1153	COG2995	paraquat-inducible protein a
DM57_11555	COG2963	transposase activity
DM57_1156	COG2353	YceI-like domain
DM57_1157	COG2353	YceI-like domain
DM57_11570	COG5295	Hep Hag repeat protein
DM57_1159	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM57_116	COG2267	carboxylic ester hydrolase activity
DM57_1160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM57_1161	COG1862	Preprotein translocase
DM57_11615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DM57_1162	COG0343	queuine tRNA-ribosyltransferase activity
DM57_11620	COG1960	acyl-CoA dehydrogenase activity
DM57_1164	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM57_11645	COG4638	Rieske (2fe-2S)
DM57_11675	COG2271	Major facilitator Superfamily
DM57_11690	COG0745	RESPONSE REGULATOR receiver
DM57_117	COG0251	oxidation-reduction process
DM57_1170	COG1733	regulation of RNA biosynthetic process
DM57_11710	COG1477	protein flavinylation
DM57_11715	COG1012	belongs to the aldehyde dehydrogenase family
DM57_11720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM57_1173	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DM57_11730	COG0583	DNA-binding transcription factor activity
DM57_11735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM57_1174	COG2188	Transcriptional regulator
DM57_1175	COG3624	Phosphonate C-P lyase system protein PhnG
DM57_11750	COG1349	DNA-binding transcription factor activity
DM57_11755	COG2271	Major facilitator Superfamily
DM57_11760	COG0246	Mannitol dehydrogenase
DM57_1177	COG3626	phosphonate metabolism
DM57_11770	COG4948	Mandelate Racemase Muconate Lactonizing
DM57_11775	COG1063	alcohol dehydrogenase
DM57_1178	COG3627	carbon phosphorus lyase activity
DM57_1179	COG4107	phosphonate C-P lyase system protein PhnK
DM57_118	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DM57_1180	COG4778	phosphonate C-P lyase system protein PhnL
DM57_11800	COG5441	Belongs to the UPF0261 family
DM57_11805	COG5564	TIM-barrel signal transduction protein
DM57_1181	COG3454	Phosphonate metabolism
DM57_1182	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DM57_11830	COG3023	N-Acetylmuramoyl-L-alanine amidase
DM57_11845	COG5295	Hep Hag repeat protein
DM57_1185	COG3639	organic phosphonate transmembrane transporter activity
DM57_1188	COG0247	lactate metabolic process
DM57_1189	COG0277	FAD linked oxidase domain protein
DM57_1190	COG0277	FAD linked oxidase domain protein
DM57_1191	COG0277	FAD linked oxidase domain protein
DM57_1192	COG2096	Adenosyltransferase
DM57_1193	COG1017	nitric oxide dioxygenase activity
DM57_1193	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DM57_11960	COG0302	gtp cyclohydrolase
DM57_11965	COG2963	transposase activity
DM57_1198	COG0418	dihydroorotase activity
DM57_1199	COG0121	glutamine amidotransferase
DM57_11990	COG2916	Histone family protein nucleoid-structuring protein H-NS
DM57_12000	COG1113	amino acid transport
DM57_12015	COG4221	oxidoreductase activity
DM57_12040	COG0589	response to stress
DM57_1206	COG1126	abc transporter atp-binding protein
DM57_1207	COG0765	amino acid transport
DM57_1208	COG0765	amino acid transport
DM57_12085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM57_121	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DM57_12100	COG3291	Pkd domain containing protein
DM57_12110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DM57_12115	COG2175	clavaminate synthase activity
DM57_1212	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DM57_1213	COG0583	DNA-binding transcription factor activity
DM57_12130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DM57_1214	COG2223	nitrite transmembrane transporter activity
DM57_12160	COG2373	Large extracellular alpha-helical protein
DM57_12165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM57_12175	COG2201	protein-glutamate methylesterase activity
DM57_1218	COG0800	Aldolase
DM57_12180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM57_12180	COG4191	Histidine kinase
DM57_1220	COG1737	Transcriptional regulator
DM57_12215	COG1448	Aminotransferase
DM57_1222	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DM57_12225	COG1522	sequence-specific DNA binding
DM57_1223	COG1466	dna polymerase III delta subunit
DM57_12245	COG1272	protein, Hemolysin III
DM57_1225	COG0495	leucyl-tRNA aminoacylation
DM57_12280	COG2916	Histone family protein nucleoid-structuring protein H-NS
DM57_12285	COG5295	Hep Hag repeat protein
DM57_12285	COG5295	Hep Hag repeat protein
DM57_1229	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM57_1230	COG0735	belongs to the Fur family
DM57_12310	COG2963	transposase activity
DM57_12325	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_1233	COG4266	Belongs to the allantoicase family
DM57_12335	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_1234	COG1301	dicarboxylic acid transport
DM57_12345	COG2721	sulfolactate sulfo-lyase activity
DM57_12355	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM57_1236	COG0583	DNA-binding transcription factor activity
DM57_12360	COG1129	ABC transporter
DM57_12380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_12385	COG2814	Major facilitator Superfamily
DM57_1239	COG2814	Major facilitator Superfamily
DM57_12395	COG1012	belongs to the aldehyde dehydrogenase family
DM57_1240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DM57_12400	COG1024	Enoyl-CoA hydratase
DM57_1241	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DM57_1242	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DM57_1244	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DM57_12440	COG1846	Transcriptional regulator
DM57_12460	COG2197	response regulator
DM57_12475	COG3511	phospholipase C
DM57_12480	COG1858	cytochrome C peroxidase
DM57_1249	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DM57_12490	COG0038	chloride channel
DM57_125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM57_125	COG0072	phenylalanine-tRNA ligase activity
DM57_1250	COG1546	Belongs to the CinA family
DM57_12505	COG3246	L-lysine catabolic process to acetate
DM57_1251	COG0284	orotidine-5'-phosphate decarboxylase activity
DM57_12520	COG0402	S-adenosylhomocysteine deaminase activity
DM57_12525	COG2508	Transcriptional regulator
DM57_1253	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_12530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DM57_1254	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM57_12540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_1255	COG1129	ABC transporter
DM57_12555	COG0583	DNA-binding transcription factor activity
DM57_1257	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_1259	COG3734	2-keto-3-deoxy-galactonokinase
DM57_12595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_126	COG0776	regulation of translation
DM57_1260	COG1414	Transcriptional regulator
DM57_12610	COG2963	transposase activity
DM57_1263	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DM57_12630	COG2186	Transcriptional regulator
DM57_12635	COG2084	Dehydrogenase
DM57_12640	COG3395	kinase activity
DM57_12645	COG0235	Class ii aldolase
DM57_1265	COG0557	exoribonuclease II activity
DM57_12650	COG2271	Major facilitator Superfamily
DM57_12655	COG3622	Belongs to the hyi family
DM57_1266	COG3150	esterase
DM57_12660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM57_1267	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DM57_1269	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM57_12695	COG4175	Glycine betaine
DM57_1270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DM57_1271	COG0511	ligase activity, forming carbon-carbon bonds
DM57_12715	COG0640	Transcriptional regulator
DM57_1272	COG0439	Biotin carboxylase
DM57_12730	COG0798	PFAM Bile acid sodium symporter
DM57_1275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DM57_12795	COG1024	Enoyl-CoA hydratase
DM57_12805	COG0183	Belongs to the thiolase family
DM57_12810	COG1024	Enoyl-CoA hydratase
DM57_12825	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DM57_12835	COG2967	ApaG domain
DM57_12845	COG0546	phosphoglycolate phosphatase activity
DM57_1285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DM57_12855	COG0512	Glutamine amidotransferase of anthranilate synthase
DM57_1287	COG2095	MarC family integral membrane protein
DM57_12875	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DM57_12880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DM57_12890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DM57_12895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM57_12910	COG0012	GTP binding
DM57_12940	COG0584	glycerophosphoryl diester phosphodiesterase
DM57_1295	COG0142	geranyltranstransferase activity
DM57_12955	COG0488	(ABC) transporter
DM57_12965	COG1335	isochorismatase
DM57_12975	COG0006	proline dipeptidase activity
DM57_13	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM57_13005	COG2890	protein-(glutamine-N5) methyltransferase activity
DM57_13010	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DM57_13020	COG3384	dioxygenase
DM57_13025	COG0531	amino acid
DM57_1303	COG4536	flavin adenine dinucleotide binding
DM57_13035	COG2963	transposase activity
DM57_1304	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DM57_13055	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM57_1306	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DM57_13060	COG3246	L-lysine catabolic process to acetate
DM57_1307	COG0237	dephospho-CoA kinase activity
DM57_1309	COG0494	nUDIX hydrolase
DM57_13095	COG3119	arylsulfatase activity
DM57_1311	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DM57_13115	COG2113	Glycine betaine
DM57_13135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DM57_13140	COG2181	nitrate reductase activity
DM57_13140	COG0247	lactate metabolic process
DM57_13145	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM57_13145	COG1902	pentaerythritol trinitrate reductase activity
DM57_1315	COG0678	peroxiredoxin activity
DM57_13160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DM57_1318	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DM57_13180	COG1621	beta-fructofuranosidase activity
DM57_13185	COG1566	PFAM secretion protein HlyD family protein
DM57_13205	COG2814	Major facilitator Superfamily
DM57_1325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DM57_1326	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM57_1328	COG3116	cell division
DM57_13280	COG3501	Rhs element vgr protein
DM57_13285	COG3501	Rhs element vgr protein
DM57_1332	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_13325	COG2963	transposase activity
DM57_13345	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM57_13355	COG3842	ATPase activity
DM57_13370	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DM57_13375	COG4771	TonB-dependent receptor
DM57_13385	COG3038	cytochrome b561
DM57_13420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DM57_13425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DM57_1344	COG3396	Phenylacetate-CoA oxygenase
DM57_1345	COG3460	Phenylacetate-CoA oxygenase
DM57_1346	COG3396	Phenylacetate-CoA oxygenase
DM57_13460	COG3501	Rhs element vgr protein
DM57_1347	COG2151	metal-sulfur cluster biosynthetic enzyme
DM57_1348	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DM57_1352	COG1522	sequence-specific DNA binding
DM57_1356	COG0280	phosphate acetyltransferase
DM57_1356	COG0281	malic enzyme
DM57_1357	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DM57_1358	COG1881	PFAM PEBP family protein
DM57_13580	COG0583	DNA-binding transcription factor activity
DM57_136	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DM57_1360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DM57_13600	COG0477	Major facilitator Superfamily
DM57_13605	COG1104	cysteine desulfurase activity
DM57_13620	COG0477	Major facilitator Superfamily
DM57_13625	COG0583	DNA-binding transcription factor activity
DM57_1363	COG3047	cAMP biosynthetic process
DM57_13630	COG1304	FMN binding
DM57_13635	COG0179	Fumarylacetoacetate (FAA) hydrolase
DM57_1366	COG2963	transposase activity
DM57_13660	COG2916	Histone family protein nucleoid-structuring protein H-NS
DM57_1367	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DM57_1368	COG1333	cytochrome c biogenesis protein
DM57_13685	COG2610	gluconate transmembrane transporter activity
DM57_137	COG2963	transposase activity
DM57_1370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DM57_13705	COG4608	Belongs to the ABC transporter superfamily
DM57_13715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM57_1372	COG4232	protein-disulfide reductase activity
DM57_13720	COG0601	transmembrane transport
DM57_13735	COG3104	oligopeptide transport
DM57_13775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM57_1380	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DM57_13800	COG2081	HI0933 family
DM57_13805	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DM57_1381	COG0201	protein transport
DM57_13820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DM57_13825	COG0142	geranyltranstransferase activity
DM57_1384	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DM57_13845	COG0412	Dienelactone hydrolase
DM57_13860	COG1252	NADH dehydrogenase
DM57_13870	COG1611	Belongs to the LOG family
DM57_13880	COG1683	Conserved Protein
DM57_1389	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DM57_13895	COG4695	Portal protein
DM57_13900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DM57_1391	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DM57_13925	COG1846	Transcriptional regulator
DM57_13930	COG1764	response to oxidative stress
DM57_13950	COG0725	ABC transporter, periplasmic molybdate-binding protein
DM57_13955	COG4149	molybdate abc transporter
DM57_1398	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DM57_13980	COG0583	DNA-binding transcription factor activity
DM57_13995	COG1253	flavin adenine dinucleotide binding
DM57_14000	COG0352	thiamine-phosphate diphosphorylase activity
DM57_14005	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DM57_14020	COG1304	FMN binding
DM57_1404	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DM57_1405	COG0049	tRNA binding
DM57_1407	COG0514	ATP-dependent DNA helicase (RecQ)
DM57_14075	COG0247	lactate metabolic process
DM57_14080	COG1592	Rubrerythrin
DM57_14085	COG3023	N-Acetylmuramoyl-L-alanine amidase
DM57_14090	COG4941	Belongs to the sigma-70 factor family
DM57_14100	COG3795	YCII-related domain
DM57_14105	COG3795	YCII-related domain
DM57_14125	COG0628	permease
DM57_14135	COG4771	TonB-dependent receptor
DM57_14145	COG2130	NADP-dependent
DM57_1416	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DM57_14165	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_14185	COG0583	DNA-binding transcription factor activity
DM57_14210	COG2837	iron assimilation
DM57_14215	COG5265	(ABC) transporter
DM57_14225	COG4977	sequence-specific DNA binding
DM57_1425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DM57_14255	COG0038	chloride channel
DM57_1426	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DM57_14265	COG2201	protein-glutamate methylesterase activity
DM57_14290	COG0840	transmembrane signaling receptor activity
DM57_14295	COG0642	Histidine kinase
DM57_14310	COG1012	belongs to the aldehyde dehydrogenase family
DM57_14320	COG0025	NhaP-type Na H and K H
DM57_14340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM57_14355	COG2146	nitrite reductase [NAD(P)H] activity
DM57_1436	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DM57_14360	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DM57_14365	COG4638	Rieske (2fe-2S)
DM57_1438	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DM57_14395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DM57_1440	COG1175	transmembrane transport
DM57_1441	COG0395	ABC-type sugar transport system, permease component
DM57_1442	COG3842	ATPase activity
DM57_14420	COG1902	pentaerythritol trinitrate reductase activity
DM57_14420	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM57_1443	COG0584	glycerophosphoryl diester phosphodiesterase
DM57_14435	COG0583	DNA-binding transcription factor activity
DM57_14440	COG4638	Rieske (2fe-2S)
DM57_14445	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
DM57_14450	COG0543	2 iron, 2 sulfur cluster binding
DM57_14450	COG0633	Ferredoxin
DM57_14455	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_1446	COG0070	glutamate synthase
DM57_1446	COG0067	glutamate synthase
DM57_1446	COG0069	glutamate synthase activity
DM57_14470	COG1335	isochorismatase
DM57_1448	COG1115	amino acid carrier protein
DM57_1450	COG4178	(ABC) transporter
DM57_14505	COG0833	amino acid
DM57_1453	COG2022	thiamine diphosphate biosynthetic process
DM57_14530	COG5001	Diguanylate cyclase
DM57_14530	COG5002	protein histidine kinase activity
DM57_14530	COG3447	MASE1 domain protein
DM57_1455	COG1127	ABC transporter
DM57_1456	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM57_14565	COG1136	(ABC) transporter
DM57_1457	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DM57_14570	COG2072	flavoprotein involved in K transport
DM57_14580	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_146	COG0583	DNA-binding transcription factor activity
DM57_14605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DM57_1461	COG1131	(ABC) transporter
DM57_14615	COG1126	abc transporter atp-binding protein
DM57_1462	COG0842	Transport permease protein
DM57_14620	COG0765	amino acid transport
DM57_14625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM57_14635	COG1657	PFAM Prenyltransferase squalene oxidase
DM57_1464	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DM57_14645	COG1562	ergosterol biosynthetic process
DM57_14655	COG3706	GGDEF domain
DM57_1466	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DM57_1467	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM57_14680	COG1595	DNA-templated transcription, initiation
DM57_1469	COG2095	MarC family integral membrane protein
DM57_14690	COG1393	Belongs to the ArsC family
DM57_14695	COG1192	Involved in chromosome partitioning
DM57_147	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DM57_1470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DM57_14740	COG1396	sequence-specific DNA binding
DM57_14760	COG1309	transcriptional regulator
DM57_14775	COG0473	3-isopropylmalate dehydrogenase activity
DM57_1478	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM57_14780	COG0583	DNA-binding transcription factor activity
DM57_1479	COG0805	protein transport
DM57_148	COG1187	pseudouridine synthase activity
DM57_1480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM57_1481	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DM57_1482	COG0723	plastoquinol--plastocyanin reductase activity
DM57_1483	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DM57_1484	COG2857	Cytochrome c1
DM57_1485	COG0625	glutathione transferase activity
DM57_1486	COG2969	positive regulation of protein catabolic process
DM57_14875	COG1538	Outer membrane efflux protein
DM57_1489	COG4695	Portal protein
DM57_1490	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DM57_1491	COG3657	addiction module killer protein
DM57_1492	COG2963	transposase activity
DM57_1495	COG1987	bacterial-type flagellum assembly
DM57_1497	COG0789	Transcriptional regulator
DM57_1498	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DM57_1498	COG4106	trans-aconitate 2-methyltransferase activity
DM57_15	COG3539	Fimbrial protein
DM57_150	COG0195	Participates in both transcription termination and antitermination
DM57_150	COG2251	uridine kinase activity
DM57_1500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM57_1502	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM57_1505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_1508	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_15095	COG0596	Alpha beta hydrolase
DM57_1520	COG1695	Transcriptional regulator
DM57_1523	COG2963	transposase activity
DM57_15245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DM57_1526	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM57_1529	COG1346	cytolysis
DM57_153	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DM57_1531	COG0583	DNA-binding transcription factor activity
DM57_1532	COG2814	Major facilitator Superfamily
DM57_1533	COG1846	Transcriptional regulator
DM57_154	COG2814	Major facilitator Superfamily
DM57_1542	COG2165	general secretion pathway protein
DM57_15435	COG2963	transposase activity
DM57_15455	COG2963	transposase activity
DM57_15460	COG1278	Cold shock
DM57_1548	COG0741	lytic transglycosylase activity
DM57_1549	COG0523	cobalamin synthesis protein
DM57_155	COG1566	PFAM secretion protein HlyD family protein
DM57_15505	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DM57_15535	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
DM57_1556	COG1113	amino acid transport
DM57_15585	COG2963	transposase activity
DM57_1559	COG2823	Periplasmic or secreted lipoprotein
DM57_1560	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DM57_1564	COG0443	Heat shock 70 kDa protein
DM57_15655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DM57_157	COG1846	Transcriptional regulator
DM57_1573	COG0308	aminopeptidase N
DM57_15875	COG2963	transposase activity
DM57_159	COG0567	Dehydrogenase, E1 component
DM57_1591	COG0412	Dienelactone hydrolase
DM57_15910	COG2963	transposase activity
DM57_1593	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DM57_1594	COG1950	PFAM Membrane protein of
DM57_1596	COG1191	sigma factor activity
DM57_15985	COG5295	Hep Hag repeat protein
DM57_1599	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM57_160	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM57_1601	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM57_1605	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DM57_1606	COG0745	RESPONSE REGULATOR receiver
DM57_1607	COG2201	protein-glutamate methylesterase activity
DM57_16070	COG0739	heme binding
DM57_1609	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DM57_161	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM57_1611	COG0835	chemotaxis
DM57_1613	COG2201	protein-glutamate methylesterase activity
DM57_1619	COG0438	transferase activity, transferring glycosyl groups
DM57_162	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DM57_1621	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DM57_1622	COG0561	phosphatase activity
DM57_1624	COG0519	Catalyzes the synthesis of GMP from XMP
DM57_1631	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM57_1634	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_1639	COG1280	lysine exporter protein (LysE YggA)
DM57_1645	COG2267	carboxylic ester hydrolase activity
DM57_1648	COG3397	chitin binding
DM57_1651	COG2963	transposase activity
DM57_1653	COG0582	viral genome integration into host DNA
DM57_1655	COG3245	cytochrome
DM57_1656	COG0210	DNA helicase
DM57_1659	COG0673	inositol 2-dehydrogenase activity
DM57_1662	COG0509	glycine decarboxylation via glycine cleavage system
DM57_1665	COG1760	l-serine dehydratase
DM57_1670	COG1012	belongs to the aldehyde dehydrogenase family
DM57_1672	COG4302	ethanolamine ammonia-lyase activity
DM57_1673	COG4303	Ethanolamine ammonia lyase large subunit
DM57_1675	COG0531	amino acid
DM57_1677	COG0668	transmembrane transport
DM57_1680	COG0789	Transcriptional regulator
DM57_1682	COG0277	FAD linked oxidase domain protein
DM57_1685	COG0436	Aminotransferase
DM57_1687	COG1960	acyl-CoA dehydrogenase activity
DM57_169	COG2963	transposase activity
DM57_1690	COG0506	proline dehydrogenase activity
DM57_1690	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DM57_1690	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DM57_1692	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DM57_1695	COG1832	CoA-binding protein
DM57_1696	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_17	COG3121	Chaperone
DM57_1704	COG0356	it plays a direct role in the translocation of protons across the membrane
DM57_1706	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DM57_1707	COG1475	DNA binding
DM57_1708	COG1192	Involved in chromosome partitioning
DM57_1712	COG0411	ABC transporter
DM57_1717	COG0559	Belongs to the binding-protein-dependent transport system permease family
DM57_1720	COG0411	ABC transporter
DM57_1723	COG0583	DNA-binding transcription factor activity
DM57_1725	COG1522	sequence-specific DNA binding
DM57_1726	COG3186	Phenylalanine-4-hydroxylase
DM57_1727	COG2154	pterin-4-alpha-carbinolamine dehydratase
DM57_1730	COG0642	Histidine kinase
DM57_1732	COG1902	pentaerythritol trinitrate reductase activity
DM57_1733	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DM57_1733	COG0519	Catalyzes the synthesis of GMP from XMP
DM57_174	COG2197	response regulator
DM57_1741	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM57_1743	COG1522	sequence-specific DNA binding
DM57_1750	COG2963	transposase activity
DM57_1751	COG0629	single-stranded DNA binding
DM57_1752	COG2814	Major facilitator Superfamily
DM57_1757	COG1280	lysine exporter protein (LysE YggA)
DM57_1761	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DM57_1764	COG1137	ATPase activity
DM57_1766	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DM57_1767	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DM57_1772	COG1194	a g-specific adenine glycosylase
DM57_1778	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DM57_1780	COG0193	aminoacyl-tRNA hydrolase activity
DM57_1781	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM57_1782	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DM57_1784	COG0742	ribosomal rna small subunit methyltransferase
DM57_1786	COG0625	glutathione transferase activity
DM57_1787	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM57_1789	COG0243	molybdopterin cofactor binding
DM57_1790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DM57_1792	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM57_1794	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DM57_1795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM57_1801	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DM57_1804	COG0587	DNA-directed DNA polymerase activity
DM57_1806	COG2814	Major facilitator Superfamily
DM57_1813	COG2226	methyltransferase
DM57_1815	COG1960	acyl-CoA dehydrogenase activity
DM57_1826	COG0583	DNA-binding transcription factor activity
DM57_1827	COG2188	Transcriptional regulator
DM57_1828	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DM57_1829	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM57_183	COG3121	Chaperone
DM57_1830	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM57_1830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM57_1831	COG2190	(PTS) system
DM57_1831	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM57_1831	COG1263	PTS System
DM57_1835	COG1294	oxidase, subunit
DM57_1841	COG0840	transmembrane signaling receptor activity
DM57_1843	COG1999	signal sequence binding
DM57_1845	COG1612	heme a metabolic process
DM57_1851	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DM57_1852	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DM57_1855	COG2226	methyltransferase
DM57_1856	COG1040	competence protein
DM57_1858	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DM57_1862	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DM57_1864	COG0793	Belongs to the peptidase S41A family
DM57_1865	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DM57_1866	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM57_1867	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM57_1869	COG0189	ligase activity
DM57_1872	COG0004	ammonium transporteR
DM57_1874	COG2960	long-chain fatty acid transporting porin activity
DM57_1879	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM57_1884	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DM57_1886	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM57_1887	COG1960	acyl-CoA dehydrogenase activity
DM57_1888	COG1960	acyl-CoA dehydrogenase activity
DM57_1889	COG1024	Enoyl-CoA hydratase
DM57_1889	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM57_1890	COG0583	DNA-binding transcription factor activity
DM57_1895	COG1064	alcohol dehydrogenase
DM57_1897	COG2207	Transcriptional regulator
DM57_1899	COG2814	Major facilitator Superfamily
DM57_19	COG1132	(ABC) transporter
DM57_1902	COG1309	transcriptional regulator
DM57_1907	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DM57_1909	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DM57_1910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DM57_1911	COG0523	cobalamin synthesis protein
DM57_1913	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DM57_1916	COG1560	Kdo2-lipid A biosynthetic process
DM57_1921	COG0667	Aldo Keto reductase
DM57_1924	COG2814	Major facilitator Superfamily
DM57_1926	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DM57_193	COG0475	glutathione-regulated potassium exporter activity
DM57_1934	COG1157	protein secretion by the type III secretion system
DM57_1936	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM57_1942	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM57_1945	COG0531	amino acid
DM57_1950	COG1280	lysine exporter protein (LysE YggA)
DM57_1951	COG3568	Endonuclease Exonuclease Phosphatase
DM57_1954	COG0579	oxidoreductase
DM57_1956	COG0477	Major facilitator Superfamily
DM57_1957	COG0747	negative chemotaxis
DM57_1958	COG0601	transmembrane transport
DM57_196	COG2376	Dihydroxyacetone kinase
DM57_1961	COG0444	Belongs to the ABC transporter superfamily
DM57_1962	COG4608	Belongs to the ABC transporter superfamily
DM57_1967	COG1984	allophanate hydrolase subunit 2
DM57_1968	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DM57_1970	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DM57_1971	COG0741	lytic transglycosylase activity
DM57_1977	COG2747	anti-sigma28 factor FlgM
DM57_198	COG0840	transmembrane signaling receptor activity
DM57_1980	COG1815	bacterial-type flagellum-dependent cell motility
DM57_1981	COG1558	bacterial-type flagellum-dependent cell motility
DM57_1982	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DM57_1983	COG1749	Flagellar hook protein flgE
DM57_1985	COG4786	Flagellar basal body rod
DM57_1986	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DM57_1987	COG1706	bacterial-type flagellum-dependent cell motility
DM57_1989	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DM57_1990	COG1256	bacterial-type flagellum assembly
DM57_1991	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DM57_1992	COG2233	PERMEase
DM57_1997	COG2824	Alkylphosphonate utilization operon protein PhnA
DM57_1999	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_2005	COG2963	transposase activity
DM57_2007	COG0592	DNA-directed DNA polymerase activity
DM57_2016	COG2963	transposase activity
DM57_2017	COG4681	YaeQ
DM57_2019	COG2169	Transcriptional regulator
DM57_2019	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DM57_202	COG4263	nitrous-oxide reductase activity
DM57_2022	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM57_2025	COG0583	DNA-binding transcription factor activity
DM57_2028	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM57_2030	COG4695	Portal protein
DM57_2034	COG2963	transposase activity
DM57_2039	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM57_2040	COG0583	DNA-binding transcription factor activity
DM57_2043	COG0758	DNA mediated transformation
DM57_2044	COG0242	peptide deformylase activity
DM57_2045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DM57_2048	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DM57_2048	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM57_205	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DM57_2050	COG5000	phosphorelay sensor kinase activity
DM57_2051	COG2204	response regulator
DM57_2054	COG0602	queuosine metabolic process
DM57_2055	COG0720	synthase
DM57_2058	COG0772	Belongs to the SEDS family
DM57_2059	COG0768	penicillin binding
DM57_2062	COG1077	Cell shape determining protein MreB Mrl
DM57_2066	COG2326	polyphosphate kinase activity
DM57_2067	COG0708	Exodeoxyribonuclease III
DM57_2072	COG0583	DNA-binding transcription factor activity
DM57_2073	COG2921	Belongs to the UPF0250 family
DM57_2075	COG1686	Belongs to the peptidase S11 family
DM57_2081	COG1127	ABC transporter
DM57_2082	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM57_2083	COG0737	Belongs to the 5'-nucleotidase family
DM57_2086	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DM57_2088	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DM57_2094	COG1024	Enoyl-CoA hydratase
DM57_21	COG2963	transposase activity
DM57_2105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DM57_2106	COG4221	oxidoreductase activity
DM57_2107	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_211	COG3264	Mechanosensitive ion channel
DM57_211	COG1196	nuclear chromosome segregation
DM57_2110	COG0747	negative chemotaxis
DM57_2114	COG0288	reversible hydration of carbon dioxide
DM57_2115	COG0183	Belongs to the thiolase family
DM57_2117	COG3012	SEC-C Motif Domain Protein
DM57_2126	COG1785	Belongs to the alkaline phosphatase family
DM57_2131	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_2134	COG0840	transmembrane signaling receptor activity
DM57_2135	COG1609	Transcriptional regulator
DM57_2145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM57_2148	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM57_2149	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM57_2153	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DM57_2154	COG1704	LemA family
DM57_216	COG0598	Magnesium transport protein CorA
DM57_2168	COG2963	transposase activity
DM57_2169	COG2801	Transposase and inactivated derivatives
DM57_2170	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM57_2184	COG0235	Class ii aldolase
DM57_2185	COG5001	Diguanylate cyclase
DM57_2185	COG5002	protein histidine kinase activity
DM57_2192	COG2204	response regulator
DM57_2196	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DM57_2198	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM57_2201	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DM57_2202	COG1596	polysaccharide export
DM57_2209	COG0477	Major facilitator Superfamily
DM57_2214	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DM57_2215	COG0251	oxidation-reduction process
DM57_2230	COG0494	nUDIX hydrolase
DM57_2233	COG1960	acyl-CoA dehydrogenase activity
DM57_2234	COG1024	Enoyl-CoA hydratase
DM57_2234	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM57_2235	COG0183	Belongs to the thiolase family
DM57_2236	COG1024	Enoyl-CoA hydratase
DM57_2237	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DM57_2239	COG1607	acyl-coa hydrolase
DM57_2240	COG5265	(ABC) transporter
DM57_2241	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DM57_2243	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DM57_2244	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM57_2245	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DM57_2250	COG0204	Acyl-transferase
DM57_2251	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM57_2252	COG0751	glycine-tRNA ligase activity
DM57_2254	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DM57_2256	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DM57_2258	COG1702	phosphate starvation-inducible protein PhoH
DM57_2260	COG0583	DNA-binding transcription factor activity
DM57_2261	COG2814	Major facilitator Superfamily
DM57_2262	COG1396	sequence-specific DNA binding
DM57_2264	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM57_2267	COG0367	asparagine synthase
DM57_2268	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DM57_2269	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DM57_2271	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DM57_2272	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DM57_2280	COG0513	Belongs to the DEAD box helicase family
DM57_2284	COG4948	Mandelate Racemase Muconate Lactonizing
DM57_2291	COG0840	transmembrane signaling receptor activity
DM57_2292	COG2963	transposase activity
DM57_2297	COG3307	-O-antigen
DM57_2298	COG4969	Belongs to the N-Me-Phe pilin family
DM57_2299	COG0861	Integral membrane protein TerC family
DM57_2300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DM57_2303	COG2137	regulation of response to DNA damage stimulus
DM57_2304	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DM57_2306	COG0642	Histidine kinase
DM57_2311	COG2963	transposase activity
DM57_2313	COG4783	chaperone-mediated protein folding
DM57_2315	COG0429	hydrolase of the alpha beta-hydrolase fold
DM57_2317	COG0859	PFAM glycosyl transferase family 9
DM57_2322	COG0126	phosphoglycerate kinase activity
DM57_2323	COG0469	pyruvate kinase activity
DM57_2325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DM57_2326	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DM57_2327	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DM57_2328	COG0009	L-threonylcarbamoyladenylate synthase
DM57_2333	COG0745	RESPONSE REGULATOR receiver
DM57_2335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM57_2340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM57_2341	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM57_2342	COG1538	Outer membrane efflux protein
DM57_2347	COG2963	transposase activity
DM57_235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM57_2351	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DM57_2352	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM57_2353	COG1121	(ABC) transporter
DM57_2355	COG0735	belongs to the Fur family
DM57_2357	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM57_2360	COG1175	transmembrane transport
DM57_2362	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM57_2365	COG0583	DNA-binding transcription factor activity
DM57_2368	COG2390	Transcriptional regulator
DM57_2369	COG1070	Carbohydrate kinase
DM57_2372	COG0583	DNA-binding transcription factor activity
DM57_2374	COG1012	belongs to the aldehyde dehydrogenase family
DM57_2375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM57_2376	COG2271	Major facilitator Superfamily
DM57_2380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM57_2381	COG1522	sequence-specific DNA binding
DM57_2382	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM57_2384	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DM57_2386	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DM57_2388	COG1741	Belongs to the pirin family
DM57_239	COG2855	membrane
DM57_2390	COG0860	N-Acetylmuramoyl-L-alanine amidase
DM57_2391	COG0802	atpase or kinase
DM57_2392	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DM57_2394	COG4974	Belongs to the 'phage' integrase family
DM57_2395	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_2396	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DM57_2397	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DM57_2399	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DM57_240	COG0038	chloride channel
DM57_2400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DM57_2403	COG0728	peptidoglycan biosynthetic process
DM57_2407	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DM57_2412	COG2204	response regulator
DM57_2413	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DM57_2415	COG0312	modulator of DNA gyrase
DM57_2416	COG3028	Belongs to the UPF0307 family
DM57_2417	COG0521	Mo-molybdopterin cofactor biosynthetic process
DM57_2419	COG0501	Belongs to the peptidase M48B family
DM57_243	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM57_2434	COG1522	sequence-specific DNA binding
DM57_244	COG1538	Outer membrane efflux protein
DM57_2441	COG2011	ABC-type metal ion transport system permease component
DM57_2442	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DM57_2443	COG2267	carboxylic ester hydrolase activity
DM57_2444	COG0123	including yeast histone deacetylase and acetoin utilization protein
DM57_2445	COG2951	lytic endotransglycosylase activity
DM57_245	COG0789	Transcriptional regulator
DM57_2451	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DM57_2457	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DM57_2458	COG0077	Prephenate dehydratase
DM57_2458	COG1605	Chorismate mutase
DM57_2459	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DM57_2463	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM57_2464	COG0546	phosphoglycolate phosphatase activity
DM57_2466	COG2963	transposase activity
DM57_2468	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DM57_2470	COG1910	domain protein
DM57_2473	COG3383	formate dehydrogenase (NAD+) activity
DM57_2478	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DM57_2479	COG0154	amidase activity
DM57_2480	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DM57_2482	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DM57_2483	COG2252	PERMEase
DM57_2484	COG0402	S-adenosylhomocysteine deaminase activity
DM57_2485	COG2119	membrane
DM57_2487	COG0308	aminopeptidase N
DM57_2489	COG0583	DNA-binding transcription factor activity
DM57_249	COG0252	asparaginase activity
DM57_2498	COG4772	TonB-dependent receptor
DM57_2504	COG2963	transposase activity
DM57_2505	COG0582	viral genome integration into host DNA
DM57_2508	COG2963	transposase activity
DM57_2516	COG0640	Transcriptional regulator
DM57_2517	COG1607	acyl-coa hydrolase
DM57_2518	COG0114	fumarate hydratase activity
DM57_2520	COG2963	transposase activity
DM57_2521	COG0534	Mate efflux family protein
DM57_2522	COG2501	S4 domain
DM57_2525	COG3045	CreA protein
DM57_2528	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DM57_2529	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DM57_253	COG0438	transferase activity, transferring glycosyl groups
DM57_2533	COG1322	Protein conserved in bacteria
DM57_2536	COG0303	'Molybdopterin
DM57_2538	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DM57_2539	COG1530	ribonuclease E activity
DM57_2545	COG0424	maF-like protein
DM57_2546	COG1399	metal-binding, possibly nucleic acid-binding protein
DM57_2551	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_2553	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM57_2557	COG3026	antisigma factor binding
DM57_2558	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM57_2561	COG0681	Belongs to the peptidase S26 family
DM57_2562	COG0571	ribonuclease III activity
DM57_2563	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DM57_2564	COG1381	Involved in DNA repair and RecF pathway recombination
DM57_2565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DM57_2567	COG1472	Belongs to the glycosyl hydrolase 3 family
DM57_2568	COG2204	response regulator
DM57_2572	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DM57_2576	COG1956	GAF domain-containing protein
DM57_2577	COG0583	DNA-binding transcription factor activity
DM57_2579	COG2153	protein acetylation
DM57_258	COG0084	hydrolase, TatD family'
DM57_2582	COG1999	signal sequence binding
DM57_2584	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DM57_2585	COG1132	(ABC) transporter
DM57_2586	COG0438	transferase activity, transferring glycosyl groups
DM57_2588	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM57_2589	COG0683	leucine binding
DM57_259	COG1247	-acetyltransferase
DM57_2592	COG2963	transposase activity
DM57_2594	COG3394	polysaccharide catabolic process
DM57_2597	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM57_2599	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
DM57_2600	COG3511	phospholipase C
DM57_2603	COG4160	amino acid transport
DM57_2606	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM57_2609	COG1012	belongs to the aldehyde dehydrogenase family
DM57_2611	COG2988	succinylglutamate desuccinylase activity
DM57_2613	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM57_2615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DM57_262	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DM57_2621	COG1959	2 iron, 2 sulfur cluster binding
DM57_2623	COG2151	metal-sulfur cluster biosynthetic enzyme
DM57_2624	COG0822	iron-sulfur transferase activity
DM57_2625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DM57_2627	COG0396	ATPase activity
DM57_263	COG0354	folic acid binding
DM57_2630	COG0840	transmembrane signaling receptor activity
DM57_2631	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM57_2633	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DM57_2644	COG2151	metal-sulfur cluster biosynthetic enzyme
DM57_2647	COG0415	Belongs to the DNA photolyase family
DM57_2648	COG0529	Catalyzes the synthesis of activated sulfate
DM57_2654	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DM57_2656	COG1228	amidohydrolase
DM57_2657	COG0402	S-adenosylhomocysteine deaminase activity
DM57_2659	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DM57_2660	COG0174	glutamine synthetase
DM57_2665	COG0583	DNA-binding transcription factor activity
DM57_2668	COG0175	sulfate reduction
DM57_267	COG2130	NADP-dependent
DM57_2670	COG2895	sulfate adenylyltransferase (ATP) activity
DM57_2671	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DM57_2671	COG1648	precorrin-2 dehydrogenase activity
DM57_2674	COG0795	lipopolysaccharide-transporting ATPase activity
DM57_2678	COG4654	Cytochrome c, class I
DM57_2681	COG0583	DNA-binding transcription factor activity
DM57_2687	COG4206	TonB-dependent receptor
DM57_2689	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DM57_2690	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DM57_2691	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DM57_2694	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DM57_2698	COG1492	cobalamin metabolic process
DM57_2699	COG2259	Doxx family
DM57_27	COG1879	ABC-type sugar transport system periplasmic component
DM57_2700	COG0489	protein tyrosine kinase activity
DM57_2703	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DM57_2705	COG0729	surface antigen
DM57_2706	COG2911	Protein conserved in bacteria
DM57_271	COG0183	Belongs to the thiolase family
DM57_2710	COG2885	chlorophyll binding
DM57_2710	COG3047	cAMP biosynthetic process
DM57_2711	COG0489	protein tyrosine kinase activity
DM57_2714	COG1982	Orn Lys Arg decarboxylase major
DM57_2716	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM57_272	COG1335	isochorismatase
DM57_2723	COG2226	methyltransferase
DM57_2729	COG2271	Major facilitator Superfamily
DM57_273	COG1024	Enoyl-CoA hydratase
DM57_273	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM57_2732	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DM57_2736	COG0347	Belongs to the P(II) protein family
DM57_2739	COG4160	amino acid transport
DM57_274	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_2740	COG4215	(ABC) transporter
DM57_2741	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM57_2745	COG0745	RESPONSE REGULATOR receiver
DM57_2748	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM57_2749	COG1116	anion transmembrane transporter activity
DM57_2751	COG2963	transposase activity
DM57_2759	COG1881	PFAM PEBP family protein
DM57_2760	COG2814	Major facilitator Superfamily
DM57_2763	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DM57_2770	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
DM57_2771	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DM57_2772	COG0697	spore germination
DM57_2773	COG2814	Major facilitator Superfamily
DM57_2779	COG1177	transmembrane transport
DM57_2781	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DM57_2782	COG1840	ABC-type Fe3 transport system, periplasmic component
DM57_2783	COG1609	Transcriptional regulator
DM57_2787	COG3706	GGDEF domain
DM57_2787	COG0745	RESPONSE REGULATOR receiver
DM57_279	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM57_2792	COG1522	sequence-specific DNA binding
DM57_2793	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM57_2805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM57_2809	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DM57_281	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM57_281	COG0047	phosphoribosylformylglycinamidine synthase activity
DM57_2810	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM57_2811	COG0583	DNA-binding transcription factor activity
DM57_2816	COG3052	prosthetic group binding
DM57_282	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM57_2820	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DM57_2822	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM57_2826	COG2963	transposase activity
DM57_2828	COG0477	Major facilitator Superfamily
DM57_2829	COG1742	UPF0060 membrane protein
DM57_2830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DM57_2831	COG0328	RNA-DNA hybrid ribonuclease activity
DM57_2832	COG2226	methyltransferase
DM57_2833	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM57_2834	COG1388	LysM domain
DM57_2834	COG0741	lytic transglycosylase activity
DM57_2838	COG0505	Belongs to the CarA family
DM57_2840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DM57_2841	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DM57_2843	COG1534	Rna-binding protein
DM57_2845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DM57_2846	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DM57_2848	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DM57_2849	COG0573	inorganic phosphate transmembrane transporter activity
DM57_285	COG4181	ATPase activity
DM57_2850	COG0581	inorganic phosphate transmembrane transporter activity
DM57_2853	COG0745	RESPONSE REGULATOR receiver
DM57_2855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DM57_2870	COG0534	Mate efflux family protein
DM57_2872	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM57_2874	COG4942	peptidase
DM57_2882	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DM57_2892	COG0366	Alpha amylase catalytic
DM57_2893	COG0366	Alpha amylase catalytic
DM57_2898	COG0583	DNA-binding transcription factor activity
DM57_2899	COG0745	RESPONSE REGULATOR receiver
DM57_29	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM57_2906	COG0457	Tetratricopeptide repeat
DM57_2906	COG0859	PFAM glycosyl transferase family 9
DM57_2917	COG3501	Rhs element vgr protein
DM57_2922	COG1914	H( )-stimulated, divalent metal cation uptake system
DM57_2927	COG0583	DNA-binding transcription factor activity
DM57_2935	COG2197	response regulator
DM57_2937	COG2814	Major facilitator Superfamily
DM57_2938	COG1566	PFAM secretion protein HlyD family protein
DM57_2939	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DM57_294	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DM57_2940	COG3511	phospholipase C
DM57_2941	COG1858	cytochrome C peroxidase
DM57_2946	COG1051	belongs to the nudix hydrolase family
DM57_2947	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM57_2949	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM57_2950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM57_2953	COG2963	transposase activity
DM57_2962	COG0824	Thioesterase
DM57_2963	COG0559	Belongs to the binding-protein-dependent transport system permease family
DM57_2964	COG0411	ABC transporter
DM57_2966	COG3718	enzyme involved in inositol metabolism
DM57_2968	COG3962	Belongs to the TPP enzyme family
DM57_2971	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM57_2974	COG0673	inositol 2-dehydrogenase activity
DM57_2975	COG0673	inositol 2-dehydrogenase activity
DM57_2976	COG0425	Belongs to the sulfur carrier protein TusA family
DM57_2978	COG0745	RESPONSE REGULATOR receiver
DM57_298	COG1929	Belongs to the glycerate kinase type-1 family
DM57_2980	COG5002	protein histidine kinase activity
DM57_2982	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DM57_2983	COG0525	valine-tRNA ligase activity
DM57_2984	COG0210	DNA helicase
DM57_2985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DM57_2986	COG2223	nitrite transmembrane transporter activity
DM57_2987	COG0840	transmembrane signaling receptor activity
DM57_299	COG1846	Transcriptional regulator
DM57_2992	COG0583	DNA-binding transcription factor activity
DM57_2995	COG0277	FAD linked oxidase domain protein
DM57_2998	COG1295	ribonuclease BN
DM57_30	COG1063	alcohol dehydrogenase
DM57_300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM57_3001	COG0477	Major facilitator Superfamily
DM57_3005	COG2963	transposase activity
DM57_3008	COG1595	DNA-templated transcription, initiation
DM57_3014	COG0305	Participates in initiation and elongation during chromosome replication
DM57_3016	COG0306	phosphate transporter
DM57_3017	COG0791	NLP P60 protein
DM57_3018	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DM57_3019	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DM57_3020	COG0726	polysaccharide deacetylase
DM57_3023	COG0463	Glycosyl transferase, family 2
DM57_3024	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DM57_3025	COG2076	Multidrug Resistance protein
DM57_3026	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DM57_3032	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DM57_3033	COG0314	molybdopterin synthase activity
DM57_3034	COG2346	COG2346, Truncated hemoglobins
DM57_3035	COG1959	2 iron, 2 sulfur cluster binding
DM57_3036	COG0542	response to heat
DM57_3041	COG0534	Mate efflux family protein
DM57_3044	COG3228	Belongs to the MtfA family
DM57_3045	COG0477	Major facilitator Superfamily
DM57_3046	COG0789	Transcriptional regulator
DM57_3047	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DM57_3049	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DM57_3050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DM57_3052	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM57_3059	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DM57_3060	COG0670	Belongs to the BI1 family
DM57_3064	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DM57_3067	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM57_3070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DM57_3071	COG0330	HflC and HflK could
DM57_3072	COG0330	HflC and HflK could
DM57_3076	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DM57_3078	COG2183	response to ionizing radiation
DM57_3081	COG1199	ATP-dependent helicase activity
DM57_3083	COG0564	pseudouridine synthase activity
DM57_3085	COG3243	poly(R)-hydroxyalkanoic acid synthase
DM57_3086	COG0183	Belongs to the thiolase family
DM57_3087	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_3091	COG0183	Belongs to the thiolase family
DM57_3093	COG0626	cystathionine gamma-synthase activity
DM57_3094	COG0560	Phosphoserine phosphatase
DM57_3096	COG0390	transport system, permease component
DM57_3097	COG1122	ATPase activity
DM57_3098	COG2982	Protein involved in outer membrane biogenesis
DM57_3099	COG0488	(ABC) transporter
DM57_31	COG1070	Carbohydrate kinase
DM57_3102	COG2070	2-Nitropropane dioxygenase
DM57_3103	COG3047	cAMP biosynthetic process
DM57_3105	COG1914	H( )-stimulated, divalent metal cation uptake system
DM57_3106	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DM57_3107	COG3842	ATPase activity
DM57_3108	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM57_3109	COG1177	transmembrane transport
DM57_3116	COG4964	Belongs to the GSP D family
DM57_3129	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_313	COG0745	RESPONSE REGULATOR receiver
DM57_3131	COG2814	Major facilitator Superfamily
DM57_3132	COG0519	Catalyzes the synthesis of GMP from XMP
DM57_3137	COG0840	transmembrane signaling receptor activity
DM57_314	COG2205	protein histidine kinase activity
DM57_3141	COG0557	exoribonuclease II activity
DM57_3142	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM57_3143	COG3023	N-Acetylmuramoyl-L-alanine amidase
DM57_3145	COG1802	Transcriptional regulator
DM57_3146	COG0673	inositol 2-dehydrogenase activity
DM57_3148	COG2963	transposase activity
DM57_3156	COG4702	Belongs to the UPF0303 family
DM57_316	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM57_3162	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM57_3163	COG1116	anion transmembrane transporter activity
DM57_3169	COG2963	transposase activity
DM57_3173	COG1301	dicarboxylic acid transport
DM57_3174	COG1733	regulation of RNA biosynthetic process
DM57_3176	COG0667	Aldo Keto reductase
DM57_3177	COG0701	Predicted permease
DM57_3181	COG2963	transposase activity
DM57_3187	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DM57_3188	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DM57_3189	COG4208	sulfate ABC transporter
DM57_319	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DM57_3190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DM57_3191	COG0583	DNA-binding transcription factor activity
DM57_3193	COG2963	transposase activity
DM57_3195	COG2766	serine protein kinase
DM57_3196	COG2718	Belongs to the UPF0229 family
DM57_3197	COG2719	SpoVR family
DM57_3198	COG0477	Major facilitator Superfamily
DM57_32	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_3201	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DM57_3202	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM57_3206	COG4964	Belongs to the GSP D family
DM57_336	COG4266	Belongs to the allantoicase family
DM57_337	COG3195	allantoin biosynthetic process
DM57_337	COG3648	Uricase
DM57_340	COG1953	Uracil, thiamine, allantoin
DM57_343	COG1619	proteins homologs of microcin C7 resistance protein MccF
DM57_344	COG0590	tRNA wobble adenosine to inosine editing
DM57_3475	COG2885	chlorophyll binding
DM57_356	COG0697	spore germination
DM57_358	COG2867	negative regulation of translational initiation
DM57_360	COG0330	HflC and HflK could
DM57_367	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM57_369	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM57_37	COG1120	ATPase activity
DM57_375	COG0750	zinc metalloprotease
DM57_378	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DM57_383	COG0024	Methionine aminopeptidase
DM57_385	COG1187	pseudouridine synthase activity
DM57_386	COG0242	peptide deformylase activity
DM57_393	COG1393	Belongs to the ArsC family
DM57_395	COG2890	protein-(glutamine-N5) methyltransferase activity
DM57_397	COG0386	Belongs to the glutathione peroxidase family
DM57_398	COG0488	(ABC) transporter
DM57_3993	COG2814	Major facilitator Superfamily
DM57_402	COG0477	Major facilitator Superfamily
DM57_403	COG0351	phosphomethylpyrimidine kinase
DM57_4037	COG4172	Belongs to the ABC transporter superfamily
DM57_407	COG1214	PFAM Peptidase M22, glycoprotease
DM57_409	COG0513	Belongs to the DEAD box helicase family
DM57_412	COG2224	Isocitrate lyase
DM57_414	COG0583	DNA-binding transcription factor activity
DM57_4146	COG2207	Transcriptional regulator
DM57_416	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DM57_425	COG1752	Esterase of the alpha-beta hydrolase superfamily
DM57_4256	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_426	COG0791	NLP P60 protein
DM57_427	COG4172	Belongs to the ABC transporter superfamily
DM57_428	COG4239	(ABC) transporter, permease
DM57_429	COG4174	ABC transporter (Permease)
DM57_430	COG4166	transmembrane transport
DM57_433	COG0243	molybdopterin cofactor binding
DM57_438	COG0024	Methionine aminopeptidase
DM57_441	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DM57_445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DM57_448	COG3958	Transketolase
DM57_449	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DM57_45	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DM57_453	COG2175	clavaminate synthase activity
DM57_459	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DM57_46	COG4774	siderophore transport
DM57_460	COG0529	Catalyzes the synthesis of activated sulfate
DM57_460	COG2895	sulfate adenylyltransferase (ATP) activity
DM57_462	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM57_468	COG0527	aspartate kinase activity
DM57_469	COG0037	tRNA processing
DM57_47	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DM57_474	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DM57_476	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM57_477	COG1045	serine acetyltransferase
DM57_485	COG2850	peptidyl-arginine hydroxylation
DM57_486	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DM57_487	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DM57_488	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM57_490	COG0180	Tryptophanyl-tRNA synthetase
DM57_491	COG1994	Peptidase M50
DM57_492	COG0009	L-threonylcarbamoyladenylate synthase
DM57_493	COG0613	PHP domain protein
DM57_494	COG0596	Alpha beta hydrolase
DM57_495	COG2833	Protein of unknown function (DUF455)
DM57_497	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DM57_499	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DM57_501	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DM57_504	COG0658	competence protein
DM57_504	COG2333	competence protein COMEC
DM57_505	COG0084	hydrolase, TatD family'
DM57_506	COG1136	(ABC) transporter
DM57_509	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DM57_51	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DM57_510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DM57_513	COG2975	iron-sulfur cluster assembly
DM57_516	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DM57_517	COG0316	Belongs to the HesB IscA family
DM57_518	COG0822	iron-sulfur transferase activity
DM57_519	COG1104	cysteine desulfurase activity
DM57_520	COG1959	2 iron, 2 sulfur cluster binding
DM57_521	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM57_525	COG1414	Transcriptional regulator
DM57_533	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM57_534	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM57_535	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DM57_537	COG4566	intracellular signal transduction
DM57_539	COG0339	signal peptide processing
DM57_543	COG2223	nitrite transmembrane transporter activity
DM57_544	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DM57_545	COG1140	nitrate reductase beta subunit
DM57_546	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DM57_547	COG2181	nitrate reductase activity
DM57_548	COG4585	Histidine kinase
DM57_549	COG2197	response regulator
DM57_553	COG3852	Histidine kinase
DM57_556	COG1058	Belongs to the CinA family
DM57_556	COG1546	Belongs to the CinA family
DM57_56	COG0400	carboxylic ester hydrolase activity
DM57_562	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DM57_562	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DM57_564	COG0477	Major facilitator Superfamily
DM57_566	COG1960	acyl-CoA dehydrogenase activity
DM57_567	COG0583	DNA-binding transcription factor activity
DM57_571	COG2963	transposase activity
DM57_578	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DM57_579	COG1074	ATP-dependent DNA helicase activity
DM57_58	COG3979	chitinase
DM57_580	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DM57_581	COG1289	transmembrane transporter activity
DM57_584	COG1840	ABC-type Fe3 transport system, periplasmic component
DM57_586	COG3842	ATPase activity
DM57_587	COG1522	sequence-specific DNA binding
DM57_590	COG1959	2 iron, 2 sulfur cluster binding
DM57_601	COG2866	Carboxypeptidase
DM57_602	COG3022	response to hydroperoxide
DM57_604	COG0436	Aminotransferase
DM57_606	COG1024	Enoyl-CoA hydratase
DM57_609	COG1960	acyl-CoA dehydrogenase activity
DM57_613	COG1012	belongs to the aldehyde dehydrogenase family
DM57_613	COG2030	dehydratase
DM57_614	COG1960	acyl-CoA dehydrogenase activity
DM57_615	COG1960	acyl-CoA dehydrogenase activity
DM57_619	COG1007	ATP synthesis coupled electron transport
DM57_62	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DM57_625	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DM57_626	COG1034	ATP synthesis coupled electron transport
DM57_628	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DM57_635	COG0149	triose-phosphate isomerase activity
DM57_639	COG0683	leucine binding
DM57_64	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DM57_641	COG0288	reversible hydration of carbon dioxide
DM57_642	COG0659	secondary active sulfate transmembrane transporter activity
DM57_644	COG2963	transposase activity
DM57_646	COG1183	phosphatidylcholine synthase activity
DM57_650	COG0028	Belongs to the TPP enzyme family
DM57_658	COG0438	transferase activity, transferring glycosyl groups
DM57_662	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_663	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DM57_664	COG0477	Major facilitator Superfamily
DM57_666	COG0154	amidase activity
DM57_668	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM57_67	COG1649	PFAM Uncharacterised BCR, COG1649
DM57_673	COG2076	Multidrug Resistance protein
DM57_675	COG0745	RESPONSE REGULATOR receiver
DM57_676	COG2205	protein histidine kinase activity
DM57_679	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DM57_68	COG2807	transmembrane transport
DM57_680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DM57_685	COG1028	Short-chain dehydrogenase reductase Sdr
DM57_687	COG0217	transcriptional regulatory protein
DM57_688	COG0151	Belongs to the GarS family
DM57_69	COG1846	Transcriptional regulator
DM57_691	COG0799	negative regulation of ribosome biogenesis
DM57_693	COG0424	maF-like protein
DM57_694	COG1530	ribonuclease E activity
DM57_695	COG2233	PERMEase
DM57_701	COG1595	DNA-templated transcription, initiation
DM57_702	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM57_708	COG0859	PFAM glycosyl transferase family 9
DM57_709	COG0438	transferase activity, transferring glycosyl groups
DM57_713	COG1132	(ABC) transporter
DM57_716	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM57_717	COG0513	Belongs to the DEAD box helicase family
DM57_72	COG0625	glutathione transferase activity
DM57_722	COG1674	ftsk spoiiie
DM57_725	COG3387	PFAM Glycoside hydrolase 15-related
DM57_727	COG1309	transcriptional regulator
DM57_728	COG2878	Part of a membrane complex involved in electron transport
DM57_729	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DM57_73	COG0583	DNA-binding transcription factor activity
DM57_737	COG3135	benzoate transporter
DM57_739	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DM57_742	COG4106	trans-aconitate 2-methyltransferase activity
DM57_746	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM57_748	COG0697	spore germination
DM57_749	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM57_750	COG2963	transposase activity
DM57_752	COG1396	sequence-specific DNA binding
DM57_753	COG0235	Class ii aldolase
DM57_754	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM57_755	COG2258	MOSC domain
DM57_756	COG2267	carboxylic ester hydrolase activity
DM57_758	COG0583	DNA-binding transcription factor activity
DM57_760	COG1187	pseudouridine synthase activity
DM57_763	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DM57_763	COG0543	2 iron, 2 sulfur cluster binding
DM57_764	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM57_765	COG0456	acetyltransferase
DM57_77	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DM57_771	COG2963	transposase activity
DM57_774	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM57_777	COG2963	transposase activity
DM57_78	COG2235	arginine
DM57_780	COG1215	transferase activity, transferring glycosyl groups
DM57_795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DM57_797	COG1678	Uncharacterized ACR, COG1678
DM57_799	COG1773	rubredoxin
DM57_8	COG4597	amino acid ABC transporter
DM57_802	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DM57_804	COG1733	regulation of RNA biosynthetic process
DM57_805	COG0604	alcohol dehydrogenase
DM57_81	COG1174	glycine betaine transport
DM57_815	COG1280	lysine exporter protein (LysE YggA)
DM57_816	COG0584	glycerophosphoryl diester phosphodiesterase
DM57_818	COG0730	response to heat
DM57_825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM57_828	COG1120	ATPase activity
DM57_829	COG4774	siderophore transport
DM57_83	COG1125	glycine betaine transport
DM57_832	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM57_834	COG2814	Major facilitator Superfamily
DM57_837	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DM57_838	COG0583	DNA-binding transcription factor activity
DM57_839	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM57_84	COG1174	glycine betaine transport
DM57_840	COG0778	Nitroreductase
DM57_841	COG2814	Major facilitator Superfamily
DM57_845	COG2814	Major facilitator Superfamily
DM57_847	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM57_85	COG1732	Glycine betaine
DM57_852	COG1960	acyl-CoA dehydrogenase activity
DM57_853	COG0450	alkyl hydroperoxide reductase
DM57_863	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DM57_864	COG4221	oxidoreductase activity
DM57_865	COG0824	Thioesterase
DM57_869	COG0823	Involved in the tonB-independent uptake of proteins
DM57_87	COG0477	Major facilitator Superfamily
DM57_870	COG2885	chlorophyll binding
DM57_873	COG2963	transposase activity
DM57_879	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DM57_88	COG0318	PFAM AMP-dependent synthetase and ligase
DM57_881	COG0194	GDP metabolic process
DM57_882	COG1561	YicC-like family, N-terminal region
DM57_884	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DM57_885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM57_889	COG0477	Major facilitator Superfamily
DM57_891	COG0859	PFAM glycosyl transferase family 9
DM57_896	COG2894	cell division
DM57_903	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DM57_904	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DM57_905	COG1674	ftsk spoiiie
DM57_906	COG0492	ferredoxin-NADP+ reductase activity
DM57_907	COG1193	negative regulation of DNA recombination
DM57_908	COG2860	membrane
DM57_909	COG3842	ATPase activity
DM57_91	COG0835	chemotaxis
DM57_910	COG0395	ABC-type sugar transport system, permease component
DM57_913	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DM57_914	COG0363	glucosamine-6-phosphate deaminase activity
DM57_916	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM57_918	COG1126	abc transporter atp-binding protein
DM57_921	COG2814	Major facilitator Superfamily
DM57_925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM57_925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM57_93	COG2207	Transcriptional regulator
DM57_930	COG0436	Aminotransferase
DM57_932	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DM57_937	COG0762	integral membrane protein
DM57_94	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM57_941	COG2226	methyltransferase
DM57_944	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DM57_948	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM57_950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DM57_954	COG0559	Belongs to the binding-protein-dependent transport system permease family
DM57_958	COG1129	ABC transporter
DM57_96	COG3251	PFAM MbtH domain protein
DM57_964	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DM57_969	COG0859	PFAM glycosyl transferase family 9
DM57_974	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DM57_976	COG2963	transposase activity
DM57_984	COG0477	Major facilitator Superfamily
DM57_985	COG0583	DNA-binding transcription factor activity
DM57_987	COG0583	DNA-binding transcription factor activity
DM57_99	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM57_990	COG0187	DNA topoisomerase II activity
DM57_993	COG1773	rubredoxin
DM57_996	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DM57_999	COG2963	transposase activity