locus-tag	class	description
NIES4071_00070	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_00070	COG2319	Wd-40 repeat
NIES4071_00260	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NIES4071_00270	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NIES4071_00350	COG0582	viral genome integration into host DNA
NIES4071_00370	COG1475	DNA binding
NIES4071_00410	COG1192	Involved in chromosome partitioning
NIES4071_00420	COG1475	DNA binding
NIES4071_00440	COG0840	transmembrane signaling receptor activity
NIES4071_00450	COG2198	Histidine kinase
NIES4071_00450	COG0643	Histidine kinase
NIES4071_00450	COG2198	Histidine kinase
NIES4071_00450	COG0643	Histidine kinase
NIES4071_00610	COG1505	serine-type exopeptidase activity
NIES4071_00690	COG1073	alpha beta
NIES4071_00710	COG0038	chloride channel
NIES4071_00720	COG0312	modulator of DNA gyrase
NIES4071_00950	COG2207	Transcriptional regulator
NIES4071_00960	COG3631	Ketosteroid isomerase-related protein
NIES4071_00980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_01000	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_01000	COG2319	Wd-40 repeat
NIES4071_01050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES4071_01080	COG2319	Wd-40 repeat
NIES4071_01080	COG1672	PFAM Archaeal ATPase
NIES4071_01240	COG3046	protein related to deoxyribodipyrimidine photolyase
NIES4071_01330	COG0419	ATPase involved in DNA repair
NIES4071_01350	COG2133	pyrroloquinoline quinone binding
NIES4071_01360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NIES4071_01390	COG0535	radical SAM domain protein
NIES4071_01570	COG1994	Peptidase M50
NIES4071_01610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIES4071_01610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIES4071_01630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NIES4071_01670	COG2319	Wd-40 repeat
NIES4071_01670	COG3903	Transcriptional regulator
NIES4071_01700	COG2072	flavoprotein involved in K transport
NIES4071_01740	COG2319	Wd-40 repeat
NIES4071_01740	COG1672	PFAM Archaeal ATPase
NIES4071_01770	COG2205	protein histidine kinase activity
NIES4071_01780	COG2831	hemolysin activation secretion protein
NIES4071_01920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES4071_01950	COG1045	serine acetyltransferase
NIES4071_01960	COG1215	transferase activity, transferring glycosyl groups
NIES4071_02000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_02010	COG0438	transferase activity, transferring glycosyl groups
NIES4071_02050	COG2319	Wd-40 repeat
NIES4071_02050	COG1672	PFAM Archaeal ATPase
NIES4071_02080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_02130	COG0583	DNA-binding transcription factor activity
NIES4071_02160	COG3209	COG3209 Rhs family protein
NIES4071_02290	COG0745	RESPONSE REGULATOR receiver
NIES4071_02300	COG0210	DNA helicase
NIES4071_02320	COG0671	phosphoesterase, PA-phosphatase related
NIES4071_02330	COG0726	polysaccharide deacetylase
NIES4071_02420	COG0514	ATP-dependent DNA helicase (RecQ)
NIES4071_02480	COG0450	alkyl hydroperoxide reductase
NIES4071_02500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_02510	COG4597	amino acid ABC transporter
NIES4071_02520	COG0765	amino acid transport
NIES4071_02530	COG1126	abc transporter atp-binding protein
NIES4071_02580	COG1803	Methylglyoxal synthase
NIES4071_02580	COG1597	lipid kinase activity
NIES4071_02630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_02660	COG0668	transmembrane transport
NIES4071_02680	COG0628	permease
NIES4071_02740	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NIES4071_02760	COG0628	permease
NIES4071_02840	COG0693	protein deglycase activity
NIES4071_02850	COG0656	L-ascorbic acid biosynthetic process
NIES4071_02870	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_02880	COG1408	metallophosphoesterase
NIES4071_02900	COG0745	RESPONSE REGULATOR receiver
NIES4071_02910	COG3384	dioxygenase
NIES4071_02970	COG2304	oxidoreductase activity
NIES4071_03010	COG0484	heat shock protein binding
NIES4071_03020	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NIES4071_03040	COG4251	negative regulation of phosphorylation
NIES4071_03080	COG1122	ATPase activity
NIES4071_03100	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NIES4071_03110	COG0310	cobalt ion transport
NIES4071_03140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIES4071_03150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIES4071_03160	COG0640	Transcriptional regulator
NIES4071_03170	COG1047	Peptidyl-prolyl cis-trans
NIES4071_03180	COG0735	belongs to the Fur family
NIES4071_03220	COG0693	protein deglycase activity
NIES4071_03270	COG0673	inositol 2-dehydrogenase activity
NIES4071_03290	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_03390	COG0582	viral genome integration into host DNA
NIES4071_03460	COG0656	L-ascorbic acid biosynthetic process
NIES4071_03490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_03500	COG1695	Transcriptional regulator
NIES4071_03520	COG5001	Diguanylate cyclase
NIES4071_03520	COG4251	negative regulation of phosphorylation
NIES4071_03520	COG3706	GGDEF domain
NIES4071_03520	COG2203	Gaf domain
NIES4071_03570	COG1994	Peptidase M50
NIES4071_03730	COG0628	permease
NIES4071_03780	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NIES4071_03870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIES4071_03880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NIES4071_03950	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_03950	COG2319	Wd-40 repeat
NIES4071_04070	COG0745	RESPONSE REGULATOR receiver
NIES4071_04070	COG3706	GGDEF domain
NIES4071_04080	COG2319	Wd-40 repeat
NIES4071_04080	COG1672	PFAM Archaeal ATPase
NIES4071_04100	COG0406	alpha-ribazole phosphatase activity
NIES4071_04110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NIES4071_04130	COG2815	serine threonine protein kinase
NIES4071_04130	COG0515	serine threonine protein kinase
NIES4071_04140	COG5002	protein histidine kinase activity
NIES4071_04200	COG0004	ammonium transporteR
NIES4071_04260	COG4191	Histidine kinase
NIES4071_04280	COG0515	serine threonine protein kinase
NIES4071_04280	COG2815	serine threonine protein kinase
NIES4071_04290	COG5002	protein histidine kinase activity
NIES4071_04290	COG0784	Response regulator, receiver
NIES4071_04290	COG2198	Histidine kinase
NIES4071_04370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NIES4071_04410	COG1132	(ABC) transporter
NIES4071_04470	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_04590	COG2198	Histidine kinase
NIES4071_04590	COG0784	Response regulator, receiver
NIES4071_04590	COG5002	protein histidine kinase activity
NIES4071_04660	COG2329	Antibiotic biosynthesis monooxygenase
NIES4071_04780	COG1111	helicase
NIES4071_04780	COG1205	dead DEAH box helicase
NIES4071_04830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NIES4071_04890	COG5001	Diguanylate cyclase
NIES4071_04890	COG4251	negative regulation of phosphorylation
NIES4071_04890	COG2203	Gaf domain
NIES4071_04890	COG3706	GGDEF domain
NIES4071_04900	COG0716	FMN binding
NIES4071_04910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_04920	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NIES4071_04930	COG1214	PFAM Peptidase M22, glycoprotease
NIES4071_04960	COG0515	serine threonine protein kinase
NIES4071_04960	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_04970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIES4071_05050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES4071_05070	COG3237	CsbD-like
NIES4071_05130	COG1846	Transcriptional regulator
NIES4071_05240	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_05240	COG2319	Wd-40 repeat
NIES4071_05290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIES4071_05360	COG1864	DNA RNA non-specific endonuclease
NIES4071_05360	COG3591	Belongs to the peptidase S1B family
NIES4071_05380	COG1404	Belongs to the peptidase S8 family
NIES4071_05450	COG3591	Belongs to the peptidase S1B family
NIES4071_05450	COG1864	DNA RNA non-specific endonuclease
NIES4071_05460	COG1404	Belongs to the peptidase S8 family
NIES4071_05480	COG2319	Wd-40 repeat
NIES4071_05480	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_05520	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIES4071_05820	COG2319	Wd-40 repeat
NIES4071_05820	COG1672	PFAM Archaeal ATPase
NIES4071_05880	COG1672	PFAM Archaeal ATPase
NIES4071_05880	COG2319	Wd-40 repeat
NIES4071_05940	COG2319	Wd-40 repeat
NIES4071_05940	COG1672	PFAM Archaeal ATPase
NIES4071_06000	COG1672	PFAM Archaeal ATPase
NIES4071_06000	COG2319	Wd-40 repeat
NIES4071_06070	COG1566	PFAM secretion protein HlyD family protein
NIES4071_06090	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_06100	COG0457	Tetratricopeptide repeat
NIES4071_06140	COG3321	synthase
NIES4071_06140	COG0604	alcohol dehydrogenase
NIES4071_06150	COG0604	alcohol dehydrogenase
NIES4071_06150	COG3321	synthase
NIES4071_06190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIES4071_06190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIES4071_06250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_06270	COG2319	Wd-40 repeat
NIES4071_06270	COG1672	PFAM Archaeal ATPase
NIES4071_06450	COG2319	Wd-40 repeat
NIES4071_06450	COG1672	PFAM Archaeal ATPase
NIES4071_06460	COG2319	Wd-40 repeat
NIES4071_06460	COG1672	PFAM Archaeal ATPase
NIES4071_06480	COG1672	PFAM Archaeal ATPase
NIES4071_06480	COG2319	Wd-40 repeat
NIES4071_06490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_06500	COG2319	Wd-40 repeat
NIES4071_06500	COG1672	PFAM Archaeal ATPase
NIES4071_06690	COG0515	serine threonine protein kinase
NIES4071_06690	COG2815	serine threonine protein kinase
NIES4071_06890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NIES4071_06900	COG4977	sequence-specific DNA binding
NIES4071_06930	COG3903	Transcriptional regulator
NIES4071_06930	COG2319	Wd-40 repeat
NIES4071_06940	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIES4071_06940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIES4071_06970	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_06980	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIES4071_07030	COG1733	regulation of RNA biosynthetic process
NIES4071_07050	COG2267	carboxylic ester hydrolase activity
NIES4071_07080	COG0277	FAD linked oxidase domain protein
NIES4071_07100	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_07110	COG2267	carboxylic ester hydrolase activity
NIES4071_07120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIES4071_07480	COG1231	oxidoreductase activity
NIES4071_07490	COG1231	oxidoreductase activity
NIES4071_07520	COG2226	methyltransferase
NIES4071_07580	COG2274	protein secretion by the type I secretion system
NIES4071_07650	COG0835	chemotaxis
NIES4071_07660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NIES4071_07660	COG0457	Tetratricopeptide repeat
NIES4071_07670	COG0840	transmembrane signaling receptor activity
NIES4071_07700	COG2201	protein-glutamate methylesterase activity
NIES4071_07780	COG2319	Wd-40 repeat
NIES4071_07780	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_07880	COG0582	viral genome integration into host DNA
NIES4071_07990	COG1480	7TM receptor with intracellular HD hydrolase
NIES4071_08000	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NIES4071_08030	COG3773	Cell wall hydrolase
NIES4071_08030	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_08050	COG1196	nuclear chromosome segregation
NIES4071_08050	COG3264	Mechanosensitive ion channel
NIES4071_08070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_08070	COG2198	Histidine kinase
NIES4071_08070	COG0784	Response regulator, receiver
NIES4071_08070	COG2205	protein histidine kinase activity
NIES4071_08140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_08150	COG4783	chaperone-mediated protein folding
NIES4071_08170	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES4071_08190	COG0668	transmembrane transport
NIES4071_08200	COG4325	translation initiation factor activity
NIES4071_08210	COG0628	permease
NIES4071_08280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_08300	COG1408	metallophosphoesterase
NIES4071_08470	COG0297	glycogen (starch) synthase activity
NIES4071_08480	COG2244	polysaccharide biosynthetic process
NIES4071_08490	COG1216	Glycosyl transferase, family 2
NIES4071_08490	COG0463	Glycosyl transferase, family 2
NIES4071_08510	COG1216	Glycosyl transferase, family 2
NIES4071_08570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIES4071_08670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES4071_08670	COG1017	nitric oxide dioxygenase activity
NIES4071_08690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES4071_08700	COG5002	protein histidine kinase activity
NIES4071_08730	COG1253	flavin adenine dinucleotide binding
NIES4071_08830	COG1950	PFAM Membrane protein of
NIES4071_08860	COG2340	Cysteine-rich secretory protein family
NIES4071_09010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NIES4071_09020	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NIES4071_09070	COG4974	Belongs to the 'phage' integrase family
NIES4071_09120	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_09120	COG2319	Wd-40 repeat
NIES4071_09140	COG2319	Wd-40 repeat
NIES4071_09140	COG3903	Transcriptional regulator
NIES4071_09150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES4071_09210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NIES4071_09230	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_09250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIES4071_09290	COG0725	ABC transporter, periplasmic molybdate-binding protein
NIES4071_09320	COG3585	molybdate ion transport
NIES4071_09340	COG0438	transferase activity, transferring glycosyl groups
NIES4071_09370	COG2197	response regulator
NIES4071_09380	COG4585	Histidine kinase
NIES4071_09390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_09450	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NIES4071_09490	COG1215	transferase activity, transferring glycosyl groups
NIES4071_09540	COG1834	amidinotransferase
NIES4071_09560	COG0302	gtp cyclohydrolase
NIES4071_09570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIES4071_09610	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIES4071_09620	COG3437	response regulator, receiver
NIES4071_09620	COG3850	Histidine kinase
NIES4071_09620	COG4999	Histidine kinase
NIES4071_09620	COG2205	protein histidine kinase activity
NIES4071_09630	COG0784	Response regulator, receiver
NIES4071_09660	COG0745	RESPONSE REGULATOR receiver
NIES4071_09670	COG5002	protein histidine kinase activity
NIES4071_09720	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_09730	COG0277	FAD linked oxidase domain protein
NIES4071_09740	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIES4071_09830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_09930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIES4071_09940	COG1121	(ABC) transporter
NIES4071_10000	COG0589	response to stress
NIES4071_100020	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NIES4071_100050	COG2205	protein histidine kinase activity
NIES4071_100060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NIES4071_100070	COG2442	InterPro IPR007367
NIES4071_100170	COG4804	nuclease activity
NIES4071_100190	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES4071_100190	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES4071_100200	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES4071_100220	COG0667	Aldo Keto reductase
NIES4071_100240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NIES4071_100250	COG1116	anion transmembrane transporter activity
NIES4071_100260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES4071_100260	COG1116	anion transmembrane transporter activity
NIES4071_100270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES4071_100280	COG4999	Histidine kinase
NIES4071_100280	COG3850	Histidine kinase
NIES4071_100280	COG3437	response regulator, receiver
NIES4071_100280	COG2205	protein histidine kinase activity
NIES4071_100290	COG0778	Nitroreductase
NIES4071_100330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NIES4071_100410	COG0495	leucyl-tRNA aminoacylation
NIES4071_100450	COG1595	DNA-templated transcription, initiation
NIES4071_100490	COG0739	heme binding
NIES4071_100500	COG0577	efflux transmembrane transporter activity
NIES4071_100500	COG1136	(ABC) transporter
NIES4071_100550	COG4651	solute:proton antiporter activity
NIES4071_100550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NIES4071_100570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NIES4071_100630	COG0784	Response regulator, receiver
NIES4071_100660	COG0840	transmembrane signaling receptor activity
NIES4071_100690	COG0672	)-iron permease
NIES4071_10070	COG0515	serine threonine protein kinase
NIES4071_10070	COG2815	serine threonine protein kinase
NIES4071_100730	COG5002	protein histidine kinase activity
NIES4071_100770	COG0450	alkyl hydroperoxide reductase
NIES4071_100800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIES4071_100880	COG0659	secondary active sulfate transmembrane transporter activity
NIES4071_100890	COG2949	membrane
NIES4071_10090	COG2815	serine threonine protein kinase
NIES4071_10090	COG0515	serine threonine protein kinase
NIES4071_100910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES4071_100940	COG4243	Vitamin k epoxide reductase
NIES4071_101030	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NIES4071_101050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NIES4071_101060	COG0640	Transcriptional regulator
NIES4071_101130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NIES4071_101150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIES4071_101160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NIES4071_101180	COG1120	ATPase activity
NIES4071_101190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES4071_101200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES4071_101210	COG4774	siderophore transport
NIES4071_101250	COG0723	plastoquinol--plastocyanin reductase activity
NIES4071_101270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NIES4071_101330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES4071_101340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES4071_101460	COG2831	hemolysin activation secretion protein
NIES4071_101620	COG0270	DNA (cytosine-5-)-methyltransferase activity
NIES4071_101660	COG0431	NADPH-dependent FMN reductase
NIES4071_101680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_101690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NIES4071_101720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIES4071_101750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIES4071_101760	COG0798	PFAM Bile acid sodium symporter
NIES4071_101770	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIES4071_101780	COG0798	PFAM Bile acid sodium symporter
NIES4071_101790	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_101800	COG0640	Transcriptional regulator
NIES4071_101820	COG2226	methyltransferase
NIES4071_101830	COG0640	Transcriptional regulator
NIES4071_102140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NIES4071_10220	COG0412	Dienelactone hydrolase
NIES4071_102210	COG1205	dead DEAH box helicase
NIES4071_102210	COG1111	helicase
NIES4071_102400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_102620	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_10290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES4071_103050	COG0443	Heat shock 70 kDa protein
NIES4071_10310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES4071_103330	COG0739	heme binding
NIES4071_10340	COG3852	Histidine kinase
NIES4071_103520	COG2197	response regulator
NIES4071_103530	COG2205	protein histidine kinase activity
NIES4071_10360	COG0170	dolichyl monophosphate biosynthetic process
NIES4071_10370	COG0589	response to stress
NIES4071_103700	COG1475	DNA binding
NIES4071_103710	COG1192	Involved in chromosome partitioning
NIES4071_103780	COG0592	DNA-directed DNA polymerase activity
NIES4071_10390	COG1131	(ABC) transporter
NIES4071_104180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIES4071_10420	COG0330	HflC and HflK could
NIES4071_104270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_104280	COG1959	2 iron, 2 sulfur cluster binding
NIES4071_104290	COG2226	methyltransferase
NIES4071_10430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NIES4071_104330	COG2217	Heavy metal translocating P-type atpase
NIES4071_104350	COG0789	Transcriptional regulator
NIES4071_104380	COG0789	Transcriptional regulator
NIES4071_104400	COG3659	wide pore channel activity
NIES4071_104410	COG0789	Transcriptional regulator
NIES4071_104440	COG0745	RESPONSE REGULATOR receiver
NIES4071_104450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES4071_104550	COG2217	Heavy metal translocating P-type atpase
NIES4071_104560	COG1230	cation diffusion facilitator family transporter
NIES4071_104590	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIES4071_104600	COG4243	Vitamin k epoxide reductase
NIES4071_10470	COG0668	transmembrane transport
NIES4071_10500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_105020	COG2226	methyltransferase
NIES4071_10510	COG2234	aminopeptidase activity
NIES4071_105130	COG0571	ribonuclease III activity
NIES4071_10520	COG5002	protein histidine kinase activity
NIES4071_105210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_105370	COG3942	CHAP domain
NIES4071_105370	COG1388	LysM domain
NIES4071_105440	COG0514	ATP-dependent DNA helicase (RecQ)
NIES4071_105890	COG2076	Multidrug Resistance protein
NIES4071_105920	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_105930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES4071_105930	COG0723	plastoquinol--plastocyanin reductase activity
NIES4071_106020	COG1525	nuclease
NIES4071_106160	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_106160	COG0515	serine threonine protein kinase
NIES4071_10630	COG2205	protein histidine kinase activity
NIES4071_106360	COG1061	Type III restriction enzyme res subunit
NIES4071_106470	COG0270	DNA (cytosine-5-)-methyltransferase activity
NIES4071_106550	COG1192	Involved in chromosome partitioning
NIES4071_10660	COG0745	RESPONSE REGULATOR receiver
NIES4071_10670	COG4191	Histidine kinase
NIES4071_106740	COG1122	ATPase activity
NIES4071_10680	COG5002	protein histidine kinase activity
NIES4071_106980	COG0582	viral genome integration into host DNA
NIES4071_107020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_107100	COG0582	viral genome integration into host DNA
NIES4071_107130	COG0582	viral genome integration into host DNA
NIES4071_107140	COG0582	viral genome integration into host DNA
NIES4071_107150	COG0582	viral genome integration into host DNA
NIES4071_107170	COG0385	Bile acid
NIES4071_10730	COG1846	Transcriptional regulator
NIES4071_107340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIES4071_107350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIES4071_107430	COG1372	Participates in initiation and elongation during chromosome replication
NIES4071_107430	COG0305	Participates in initiation and elongation during chromosome replication
NIES4071_107460	COG0515	serine threonine protein kinase
NIES4071_10760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES4071_107780	COG0515	serine threonine protein kinase
NIES4071_10780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIES4071_10800	COG0534	Mate efflux family protein
NIES4071_108530	COG1216	Glycosyl transferase, family 2
NIES4071_108600	COG3344	reverse transcriptase
NIES4071_10870	COG2255	four-way junction helicase activity
NIES4071_108740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NIES4071_109110	COG1695	Transcriptional regulator
NIES4071_109120	COG1475	DNA binding
NIES4071_109180	COG3617	BRO family, N-terminal domain
NIES4071_109250	COG3209	COG3209 Rhs family protein
NIES4071_10990	COG5001	Diguanylate cyclase
NIES4071_10990	COG5002	protein histidine kinase activity
NIES4071_11000	COG0564	pseudouridine synthase activity
NIES4071_11030	COG0363	glucosamine-6-phosphate deaminase activity
NIES4071_11070	COG1597	lipid kinase activity
NIES4071_11100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NIES4071_11170	COG1940	carbohydrate kinase activity
NIES4071_11180	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_11200	COG1487	ribonuclease activity
NIES4071_11290	COG1475	DNA binding
NIES4071_11330	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_11360	COG0033	Phosphoglucomutase
NIES4071_11410	COG2226	methyltransferase
NIES4071_11490	COG0415	Belongs to the DNA photolyase family
NIES4071_11520	COG1695	Transcriptional regulator
NIES4071_11540	COG5002	protein histidine kinase activity
NIES4071_11550	COG0768	penicillin binding
NIES4071_11570	COG0450	alkyl hydroperoxide reductase
NIES4071_11660	COG0019	diaminopimelate decarboxylase activity
NIES4071_11700	COG0367	asparagine synthase
NIES4071_11750	COG0436	Aminotransferase
NIES4071_11800	COG0583	DNA-binding transcription factor activity
NIES4071_11850	COG4172	Belongs to the ABC transporter superfamily
NIES4071_11870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIES4071_11880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_11920	COG1902	pentaerythritol trinitrate reductase activity
NIES4071_11930	COG3118	belongs to the thioredoxin family
NIES4071_11940	COG0640	Transcriptional regulator
NIES4071_11950	COG1429	ligase activity, forming nitrogen-metal bonds
NIES4071_12030	COG2337	Toxic component of a toxin-antitoxin (TA) module
NIES4071_12050	COG0784	Response regulator, receiver
NIES4071_12050	COG2198	Histidine kinase
NIES4071_12050	COG5002	protein histidine kinase activity
NIES4071_12110	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NIES4071_12180	COG0802	atpase or kinase
NIES4071_12190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NIES4071_12200	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NIES4071_12220	COG0745	RESPONSE REGULATOR receiver
NIES4071_12270	COG0438	transferase activity, transferring glycosyl groups
NIES4071_12290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIES4071_12320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NIES4071_12350	COG0438	transferase activity, transferring glycosyl groups
NIES4071_12360	COG0438	transferase activity, transferring glycosyl groups
NIES4071_12370	COG0463	Glycosyl transferase, family 2
NIES4071_12410	COG2755	lipolytic protein G-D-S-L family
NIES4071_12410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NIES4071_12420	COG0006	proline dipeptidase activity
NIES4071_12470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_12490	COG0612	Peptidase, M16
NIES4071_12670	COG3706	GGDEF domain
NIES4071_12700	COG3631	Ketosteroid isomerase-related protein
NIES4071_12730	COG1733	regulation of RNA biosynthetic process
NIES4071_12740	COG0531	amino acid
NIES4071_12750	COG2264	protein methyltransferase activity
NIES4071_12780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NIES4071_12790	COG3596	GTP binding
NIES4071_12820	COG0405	Gamma-glutamyltransferase
NIES4071_12850	COG0662	Cupin 2, conserved barrel domain protein
NIES4071_12880	COG2197	response regulator
NIES4071_12890	COG2197	response regulator
NIES4071_13100	COG1136	(ABC) transporter
NIES4071_13150	COG0625	glutathione transferase activity
NIES4071_13160	COG0753	catalase activity
NIES4071_13240	COG0745	RESPONSE REGULATOR receiver
NIES4071_13360	COG1136	(ABC) transporter
NIES4071_13360	COG0577	efflux transmembrane transporter activity
NIES4071_13380	COG2205	protein histidine kinase activity
NIES4071_13400	COG0187	DNA topoisomerase II activity
NIES4071_13400	COG1372	Participates in initiation and elongation during chromosome replication
NIES4071_13410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NIES4071_13480	COG0674	pyruvate-flavodoxin oxidoreductase activity
NIES4071_13480	COG1013	pyruvate-flavodoxin oxidoreductase activity
NIES4071_13480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NIES4071_13480	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NIES4071_13530	COG4178	(ABC) transporter
NIES4071_13610	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_13650	COG4178	(ABC) transporter
NIES4071_13690	COG4178	(ABC) transporter
NIES4071_13730	COG3320	Male sterility
NIES4071_13730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIES4071_13760	COG1672	PFAM Archaeal ATPase
NIES4071_13760	COG2319	Wd-40 repeat
NIES4071_13820	COG0668	transmembrane transport
NIES4071_13930	COG2319	Wd-40 repeat
NIES4071_13930	COG1672	PFAM Archaeal ATPase
NIES4071_13950	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_14240	COG0674	pyruvate-flavodoxin oxidoreductase activity
NIES4071_14240	COG1013	pyruvate-flavodoxin oxidoreductase activity
NIES4071_14240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NIES4071_14240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NIES4071_14290	COG0401	homolog of Blt101
NIES4071_14300	COG0023	Translation Initiation Factor
NIES4071_14310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NIES4071_14360	COG3956	TIGRFAM MazG family protein
NIES4071_14370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NIES4071_14380	COG1799	cell septum assembly
NIES4071_14390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NIES4071_14410	COG0736	holo-[acyl-carrier-protein] synthase activity
NIES4071_14420	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES4071_14440	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NIES4071_14450	COG1160	GTP binding
NIES4071_14460	COG1408	metallophosphoesterase
NIES4071_14500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_14550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NIES4071_14570	COG2205	protein histidine kinase activity
NIES4071_14570	COG0784	Response regulator, receiver
NIES4071_14590	COG1672	PFAM Archaeal ATPase
NIES4071_14590	COG2319	Wd-40 repeat
NIES4071_14600	COG5001	Diguanylate cyclase
NIES4071_14600	COG2203	Gaf domain
NIES4071_14600	COG4251	negative regulation of phosphorylation
NIES4071_14600	COG3706	GGDEF domain
NIES4071_14620	COG3706	GGDEF domain
NIES4071_14640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NIES4071_14650	COG1704	LemA family
NIES4071_14660	COG0501	Belongs to the peptidase M48B family
NIES4071_14710	COG1864	DNA RNA non-specific endonuclease
NIES4071_14710	COG3591	Belongs to the peptidase S1B family
NIES4071_14750	COG2124	cytochrome p450
NIES4071_14770	COG2323	membrane
NIES4071_14780	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NIES4071_14810	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES4071_14820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIES4071_14840	COG0811	peptide transport
NIES4071_14860	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NIES4071_14870	COG0783	Belongs to the Dps family
NIES4071_14910	COG1053	succinate dehydrogenase
NIES4071_14950	COG1215	transferase activity, transferring glycosyl groups
NIES4071_15000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_15030	COG2244	polysaccharide biosynthetic process
NIES4071_15040	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NIES4071_15070	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NIES4071_15090	COG1858	cytochrome C peroxidase
NIES4071_15100	COG0768	penicillin binding
NIES4071_15120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NIES4071_15130	COG1176	ABC-type spermidine putrescine transport system, permease component I
NIES4071_15190	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES4071_15210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIES4071_15220	COG5398	heme oxygenase
NIES4071_15250	COG0133	tryptophan synthase activity
NIES4071_15270	COG2244	polysaccharide biosynthetic process
NIES4071_15280	COG0438	transferase activity, transferring glycosyl groups
NIES4071_15290	COG0438	transferase activity, transferring glycosyl groups
NIES4071_15300	COG1215	transferase activity, transferring glycosyl groups
NIES4071_15310	COG1215	transferase activity, transferring glycosyl groups
NIES4071_15370	COG0726	polysaccharide deacetylase
NIES4071_15380	COG1215	transferase activity, transferring glycosyl groups
NIES4071_15390	COG1215	transferase activity, transferring glycosyl groups
NIES4071_15400	COG1215	transferase activity, transferring glycosyl groups
NIES4071_15510	COG0517	IMP dehydrogenase activity
NIES4071_15510	COG1125	glycine betaine transport
NIES4071_15580	COG0673	inositol 2-dehydrogenase activity
NIES4071_15670	COG2321	neutral zinc metallopeptidase
NIES4071_15720	COG0811	peptide transport
NIES4071_15750	COG0793	Belongs to the peptidase S41A family
NIES4071_15760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NIES4071_15770	COG1597	lipid kinase activity
NIES4071_15810	COG0571	ribonuclease III activity
NIES4071_15830	COG0598	Magnesium transport protein CorA
NIES4071_15850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIES4071_15860	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_15870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_15900	COG0121	glutamine amidotransferase
NIES4071_15910	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_15930	COG0415	Belongs to the DNA photolyase family
NIES4071_15940	COG0628	permease
NIES4071_16110	COG0438	transferase activity, transferring glycosyl groups
NIES4071_16130	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES4071_16130	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_16170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES4071_16190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NIES4071_16230	COG0406	alpha-ribazole phosphatase activity
NIES4071_16250	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
NIES4071_16270	COG0515	serine threonine protein kinase
NIES4071_16370	COG0515	serine threonine protein kinase
NIES4071_16370	COG3266	domain, Protein
NIES4071_16420	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_16420	COG0515	serine threonine protein kinase
NIES4071_16440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NIES4071_16450	COG3850	Histidine kinase
NIES4071_16450	COG4999	Histidine kinase
NIES4071_16450	COG2205	protein histidine kinase activity
NIES4071_16450	COG3437	response regulator, receiver
NIES4071_16570	COG0515	serine threonine protein kinase
NIES4071_16580	COG3903	Transcriptional regulator
NIES4071_16580	COG2319	Wd-40 repeat
NIES4071_16600	COG3903	Transcriptional regulator
NIES4071_16600	COG2319	Wd-40 repeat
NIES4071_16610	COG2373	Large extracellular alpha-helical protein
NIES4071_16720	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NIES4071_16760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NIES4071_16770	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NIES4071_16780	COG0556	nucleotide-excision repair
NIES4071_16890	COG0419	ATPase involved in DNA repair
NIES4071_16970	COG4636	protein conserved in cyanobacteria
NIES4071_17010	COG2223	nitrite transmembrane transporter activity
NIES4071_17080	COG1968	undecaprenyl-diphosphatase activity
NIES4071_17110	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NIES4071_17140	COG4243	Vitamin k epoxide reductase
NIES4071_17150	COG0434	BtpA family
NIES4071_17160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIES4071_17170	COG0513	Belongs to the DEAD box helicase family
NIES4071_17240	COG1215	transferase activity, transferring glycosyl groups
NIES4071_17250	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_17380	COG0003	Pfam Anion-transporting ATPase
NIES4071_17390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES4071_17410	COG0156	8-amino-7-oxononanoate synthase activity
NIES4071_17440	COG2159	amidohydrolase
NIES4071_17450	COG1032	radical SAM domain protein
NIES4071_17500	COG1278	Cold shock
NIES4071_17560	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_17570	COG0483	inositol monophosphate 1-phosphatase activity
NIES4071_17640	COG2391	methyltransferase activity
NIES4071_17660	COG2897	thiosulfate sulfurtransferase activity
NIES4071_17680	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NIES4071_17730	COG0626	cystathionine gamma-synthase activity
NIES4071_17740	COG0626	cystathionine gamma-synthase activity
NIES4071_17800	COG1959	2 iron, 2 sulfur cluster binding
NIES4071_17810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NIES4071_17820	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_17830	COG0573	inorganic phosphate transmembrane transporter activity
NIES4071_17840	COG0581	inorganic phosphate transmembrane transporter activity
NIES4071_17930	COG0671	phosphoesterase, PA-phosphatase related
NIES4071_17940	COG4191	Histidine kinase
NIES4071_18030	COG2319	Wd-40 repeat
NIES4071_18030	COG1672	PFAM Archaeal ATPase
NIES4071_18040	COG1672	PFAM Archaeal ATPase
NIES4071_18040	COG2319	Wd-40 repeat
NIES4071_18080	COG2814	Major facilitator Superfamily
NIES4071_18090	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_18090	COG0300	oxidoreductase activity
NIES4071_18090	COG3321	synthase
NIES4071_18090	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_18090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIES4071_18090	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_18090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIES4071_18090	COG3321	synthase
NIES4071_18090	COG0300	oxidoreductase activity
NIES4071_18090	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_18100	COG0017	Asparaginyl-tRNA synthetase
NIES4071_18190	COG0589	response to stress
NIES4071_18230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIES4071_18230	COG0574	Belongs to the PEP-utilizing enzyme family
NIES4071_18240	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES4071_18390	COG5002	protein histidine kinase activity
NIES4071_18400	COG0745	RESPONSE REGULATOR receiver
NIES4071_18410	COG3706	GGDEF domain
NIES4071_18410	COG0745	RESPONSE REGULATOR receiver
NIES4071_18430	COG3706	GGDEF domain
NIES4071_18430	COG2203	Gaf domain
NIES4071_18430	COG5001	Diguanylate cyclase
NIES4071_18430	COG4251	negative regulation of phosphorylation
NIES4071_18460	COG5002	protein histidine kinase activity
NIES4071_18470	COG0745	RESPONSE REGULATOR receiver
NIES4071_18490	COG2203	Gaf domain
NIES4071_18490	COG3706	GGDEF domain
NIES4071_18490	COG4251	negative regulation of phosphorylation
NIES4071_18490	COG5001	Diguanylate cyclase
NIES4071_18500	COG0745	RESPONSE REGULATOR receiver
NIES4071_18510	COG0745	RESPONSE REGULATOR receiver
NIES4071_18540	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NIES4071_18560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NIES4071_18590	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES4071_18630	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NIES4071_18680	COG3961	Belongs to the TPP enzyme family
NIES4071_18690	COG3961	Belongs to the TPP enzyme family
NIES4071_18810	COG0288	reversible hydration of carbon dioxide
NIES4071_18870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIES4071_18880	COG0719	Fe-S assembly protein
NIES4071_18890	COG0396	ATPase activity
NIES4071_18900	COG0719	Fe-S assembly protein
NIES4071_18950	COG0393	Putative heavy-metal-binding
NIES4071_18970	COG1132	(ABC) transporter
NIES4071_19000	COG0515	serine threonine protein kinase
NIES4071_19020	COG3932	Exopolysaccharide synthesis, ExoD
NIES4071_19040	COG0745	RESPONSE REGULATOR receiver
NIES4071_19040	COG3706	GGDEF domain
NIES4071_19050	COG5002	protein histidine kinase activity
NIES4071_19090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIES4071_19110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES4071_19120	COG2095	MarC family integral membrane protein
NIES4071_19190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIES4071_19190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIES4071_19250	COG0438	transferase activity, transferring glycosyl groups
NIES4071_19340	COG0726	polysaccharide deacetylase
NIES4071_19350	COG1215	transferase activity, transferring glycosyl groups
NIES4071_19370	COG1216	Glycosyl transferase, family 2
NIES4071_19420	COG0438	transferase activity, transferring glycosyl groups
NIES4071_19460	COG2171	N-acyltransferase activity
NIES4071_19560	COG0489	protein tyrosine kinase activity
NIES4071_19570	COG2119	membrane
NIES4071_19600	COG2124	cytochrome p450
NIES4071_19620	COG0730	response to heat
NIES4071_19680	COG3210	domain, Protein
NIES4071_19750	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIES4071_19760	COG0830	nickel cation binding
NIES4071_19770	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NIES4071_19840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NIES4071_19860	COG0542	response to heat
NIES4071_19900	COG1127	ABC transporter
NIES4071_19920	COG4636	protein conserved in cyanobacteria
NIES4071_19940	COG0514	ATP-dependent DNA helicase (RecQ)
NIES4071_19990	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIES4071_20010	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NIES4071_20140	COG1942	4-Oxalocrotonate Tautomerase
NIES4071_20160	COG2274	protein secretion by the type I secretion system
NIES4071_20170	COG0737	Belongs to the 5'-nucleotidase family
NIES4071_20220	COG3688	RNA-binding protein containing a PIN domain
NIES4071_20230	COG1122	ATPase activity
NIES4071_20260	COG2154	pterin-4-alpha-carbinolamine dehydratase
NIES4071_20270	COG3659	wide pore channel activity
NIES4071_20280	COG1959	2 iron, 2 sulfur cluster binding
NIES4071_20290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIES4071_20300	COG0484	heat shock protein binding
NIES4071_20380	COG0438	transferase activity, transferring glycosyl groups
NIES4071_20390	COG0438	transferase activity, transferring glycosyl groups
NIES4071_20400	COG0489	protein tyrosine kinase activity
NIES4071_20400	COG3206	protein involved in exopolysaccharide biosynthesis
NIES4071_20430	COG0438	transferase activity, transferring glycosyl groups
NIES4071_20440	COG0463	Glycosyl transferase, family 2
NIES4071_20440	COG1216	Glycosyl transferase, family 2
NIES4071_20450	COG0438	transferase activity, transferring glycosyl groups
NIES4071_20480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_20510	COG1216	Glycosyl transferase, family 2
NIES4071_20530	COG0297	glycogen (starch) synthase activity
NIES4071_20540	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
NIES4071_20580	COG0412	Dienelactone hydrolase
NIES4071_20690	COG0577	efflux transmembrane transporter activity
NIES4071_20710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_20710	COG4191	Histidine kinase
NIES4071_20820	COG2198	Histidine kinase
NIES4071_20820	COG0643	Histidine kinase
NIES4071_20830	COG2203	Gaf domain
NIES4071_20830	COG0840	transmembrane signaling receptor activity
NIES4071_20860	COG0745	RESPONSE REGULATOR receiver
NIES4071_21080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NIES4071_21120	COG2205	protein histidine kinase activity
NIES4071_21120	COG0784	Response regulator, receiver
NIES4071_21130	COG2068	MobA-Related Protein
NIES4071_21140	COG0784	Response regulator, receiver
NIES4071_21140	COG5002	protein histidine kinase activity
NIES4071_21150	COG4251	negative regulation of phosphorylation
NIES4071_21160	COG0784	Response regulator, receiver
NIES4071_21170	COG4251	negative regulation of phosphorylation
NIES4071_21260	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES4071_21270	COG0753	catalase activity
NIES4071_21300	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES4071_21380	COG3854	ATPases associated with a variety of cellular activities
NIES4071_21400	COG3706	GGDEF domain
NIES4071_21400	COG0745	RESPONSE REGULATOR receiver
NIES4071_21420	COG2203	Gaf domain
NIES4071_21420	COG3706	GGDEF domain
NIES4071_21420	COG4251	negative regulation of phosphorylation
NIES4071_21420	COG5001	Diguanylate cyclase
NIES4071_21450	COG2197	response regulator
NIES4071_21460	COG4585	Histidine kinase
NIES4071_21470	COG0729	surface antigen
NIES4071_21480	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES4071_21490	COG1131	(ABC) transporter
NIES4071_21530	COG2082	Precorrin-8x methylmutase
NIES4071_21590	COG3937	granule-associated protein
NIES4071_21600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES4071_21610	COG0631	protein serine/threonine phosphatase activity
NIES4071_21630	COG0515	serine threonine protein kinase
NIES4071_21640	COG5001	Diguanylate cyclase
NIES4071_21680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NIES4071_21720	COG0811	peptide transport
NIES4071_21740	COG4771	TonB-dependent receptor
NIES4071_21840	COG1598	PFAM Uncharacterised protein family UPF0150
NIES4071_21860	COG0322	excinuclease ABC activity
NIES4071_21870	COG0357	Ribosomal RNA small subunit methyltransferase G
NIES4071_21980	COG1122	ATPase activity
NIES4071_22070	COG1253	flavin adenine dinucleotide binding
NIES4071_22080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NIES4071_22090	COG1598	PFAM Uncharacterised protein family UPF0150
NIES4071_22100	COG1598	PFAM Uncharacterised protein family UPF0150
NIES4071_22170	COG0515	serine threonine protein kinase
NIES4071_22170	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_22180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_22190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_22220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_22260	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_22260	COG0515	serine threonine protein kinase
NIES4071_22400	COG0363	glucosamine-6-phosphate deaminase activity
NIES4071_22410	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NIES4071_22420	COG0563	adenylate kinase activity
NIES4071_22450	COG0717	Belongs to the dCTP deaminase family
NIES4071_22460	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NIES4071_22470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES4071_22550	COG0557	exoribonuclease II activity
NIES4071_22580	COG0303	'Molybdopterin
NIES4071_22690	COG0408	coproporphyrinogen oxidase activity
NIES4071_22710	COG0697	spore germination
NIES4071_22730	COG2345	Transcriptional regulator
NIES4071_22750	COG0831	urea catabolic process
NIES4071_22760	COG0832	Belongs to the urease beta subunit family
NIES4071_22870	COG0515	serine threonine protein kinase
NIES4071_22870	COG2815	serine threonine protein kinase
NIES4071_22880	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NIES4071_22890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NIES4071_22930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NIES4071_22940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIES4071_22950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NIES4071_22960	COG0544	peptidyl-prolyl cis-trans isomerase activity
NIES4071_22970	COG0740	serine-type endopeptidase activity
NIES4071_22980	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NIES4071_23000	COG2188	Transcriptional regulator
NIES4071_23010	COG0412	Dienelactone hydrolase
NIES4071_23020	COG0539	negative regulation of cytoplasmic translation
NIES4071_23050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NIES4071_23110	COG0752	glycyl-tRNA synthetase alpha subunit
NIES4071_23170	COG1606	tRNA processing
NIES4071_23180	COG2205	protein histidine kinase activity
NIES4071_23200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIES4071_23210	COG0745	RESPONSE REGULATOR receiver
NIES4071_23220	COG0515	serine threonine protein kinase
NIES4071_23220	COG2815	serine threonine protein kinase
NIES4071_23260	COG2072	flavoprotein involved in K transport
NIES4071_23310	COG0724	RNA recognition motif
NIES4071_23320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NIES4071_23320	COG1754	DNA topoisomerase type I activity
NIES4071_23340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NIES4071_23360	COG1480	7TM receptor with intracellular HD hydrolase
NIES4071_23440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NIES4071_23470	COG1506	peptidase
NIES4071_23550	COG0617	tRNA 3'-terminal CCA addition
NIES4071_23630	COG0443	Heat shock 70 kDa protein
NIES4071_23650	COG0784	Response regulator, receiver
NIES4071_23650	COG5002	protein histidine kinase activity
NIES4071_23650	COG2198	Histidine kinase
NIES4071_23810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_23860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES4071_23880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES4071_23900	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_23950	COG0438	transferase activity, transferring glycosyl groups
NIES4071_23960	COG0459	protein refolding
NIES4071_23970	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIES4071_24000	COG0596	Alpha beta hydrolase
NIES4071_24010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NIES4071_24080	COG0758	DNA mediated transformation
NIES4071_24080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIES4071_24100	COG0745	RESPONSE REGULATOR receiver
NIES4071_24110	COG5001	Diguanylate cyclase
NIES4071_24110	COG2203	Gaf domain
NIES4071_24110	COG3706	GGDEF domain
NIES4071_24110	COG4251	negative regulation of phosphorylation
NIES4071_24130	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NIES4071_24310	COG0840	transmembrane signaling receptor activity
NIES4071_24330	COG0489	protein tyrosine kinase activity
NIES4071_24360	COG0641	radical SAM
NIES4071_24390	COG2274	protein secretion by the type I secretion system
NIES4071_24470	COG0653	protein targeting
NIES4071_24500	COG0714	Associated with various cellular activities
NIES4071_24510	COG0196	riboflavin kinase activity
NIES4071_24520	COG1234	tRNA 3'-trailer cleavage
NIES4071_24550	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NIES4071_24560	COG0514	ATP-dependent DNA helicase (RecQ)
NIES4071_24590	COG0519	Catalyzes the synthesis of GMP from XMP
NIES4071_24670	COG5002	protein histidine kinase activity
NIES4071_24690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NIES4071_24700	COG0515	serine threonine protein kinase
NIES4071_24700	COG2815	serine threonine protein kinase
NIES4071_24770	COG1509	lysine 2,3-aminomutase activity
NIES4071_24780	COG3903	Transcriptional regulator
NIES4071_24780	COG2319	Wd-40 repeat
NIES4071_24820	COG1131	(ABC) transporter
NIES4071_24860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES4071_24880	COG1316	TRANSCRIPTIONal
NIES4071_24890	COG0784	Response regulator, receiver
NIES4071_24890	COG5002	protein histidine kinase activity
NIES4071_24930	COG0728	peptidoglycan biosynthetic process
NIES4071_25030	COG0442	prolyl-tRNA aminoacylation
NIES4071_25160	COG0247	lactate metabolic process
NIES4071_25170	COG0277	FAD linked oxidase domain protein
NIES4071_25190	COG5002	protein histidine kinase activity
NIES4071_25200	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NIES4071_25220	COG3659	wide pore channel activity
NIES4071_25260	COG0588	phosphoglycerate mutase activity
NIES4071_25270	COG1132	(ABC) transporter
NIES4071_25290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIES4071_25300	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NIES4071_25330	COG5002	protein histidine kinase activity
NIES4071_25360	COG0745	RESPONSE REGULATOR receiver
NIES4071_25370	COG0644	oxidoreductase
NIES4071_25390	COG0745	RESPONSE REGULATOR receiver
NIES4071_25400	COG0429	hydrolase of the alpha beta-hydrolase fold
NIES4071_25500	COG0426	domain, Protein
NIES4071_25500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES4071_25510	COG0426	domain, Protein
NIES4071_25510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES4071_25680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIES4071_25690	COG0133	tryptophan synthase activity
NIES4071_25800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES4071_25820	COG1136	(ABC) transporter
NIES4071_25820	COG0577	efflux transmembrane transporter activity
NIES4071_25840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_25850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_25870	COG0431	NADPH-dependent FMN reductase
NIES4071_25880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NIES4071_25890	COG0512	Glutamine amidotransferase of anthranilate synthase
NIES4071_25890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES4071_25900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_25910	COG2226	methyltransferase
NIES4071_25940	COG0625	glutathione transferase activity
NIES4071_25950	COG0583	DNA-binding transcription factor activity
NIES4071_25990	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_26000	COG3311	Transcriptional regulator
NIES4071_26010	COG1569	PIN domain
NIES4071_26020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NIES4071_26040	COG2197	response regulator
NIES4071_26060	COG2897	thiosulfate sulfurtransferase activity
NIES4071_26070	COG2226	methyltransferase
NIES4071_26210	COG2198	Histidine kinase
NIES4071_26210	COG0784	Response regulator, receiver
NIES4071_26210	COG5002	protein histidine kinase activity
NIES4071_26250	COG2124	cytochrome p450
NIES4071_26350	COG0405	Gamma-glutamyltransferase
NIES4071_26470	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NIES4071_26480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NIES4071_26510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_26520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES4071_26590	COG0675	Transposase, IS605 OrfB family
NIES4071_26620	COG1845	cytochrome c oxidase, subunit III
NIES4071_26650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NIES4071_26670	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_26670	COG2319	Wd-40 repeat
NIES4071_26740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_26750	COG0573	inorganic phosphate transmembrane transporter activity
NIES4071_26760	COG0581	inorganic phosphate transmembrane transporter activity
NIES4071_26770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NIES4071_26840	COG2319	Wd-40 repeat
NIES4071_26840	COG1672	PFAM Archaeal ATPase
NIES4071_26870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NIES4071_26960	COG1621	beta-fructofuranosidase activity
NIES4071_26970	COG2124	cytochrome p450
NIES4071_27130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIES4071_27140	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NIES4071_27250	COG1216	Glycosyl transferase, family 2
NIES4071_27290	COG1045	serine acetyltransferase
NIES4071_27340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES4071_27370	COG2319	Wd-40 repeat
NIES4071_27370	COG3903	Transcriptional regulator
NIES4071_27380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_27400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_27410	COG2319	Wd-40 repeat
NIES4071_27410	COG1672	PFAM Archaeal ATPase
NIES4071_27450	COG1404	Belongs to the peptidase S8 family
NIES4071_27620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NIES4071_27630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NIES4071_27710	COG0045	succinate-CoA ligase (ADP-forming) activity
NIES4071_27730	COG0390	transport system, permease component
NIES4071_27760	COG2319	Wd-40 repeat
NIES4071_27760	COG3903	Transcriptional regulator
NIES4071_27770	COG3903	Transcriptional regulator
NIES4071_27770	COG2319	Wd-40 repeat
NIES4071_27850	COG4804	nuclease activity
NIES4071_27860	COG4804	nuclease activity
NIES4071_27870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIES4071_27880	COG2183	response to ionizing radiation
NIES4071_27980	COG2010	Cytochrome c
NIES4071_28030	COG0556	nucleotide-excision repair
NIES4071_28060	COG1943	Transposase
NIES4071_28080	COG1473	amidohydrolase
NIES4071_28090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NIES4071_28100	COG0515	serine threonine protein kinase
NIES4071_28100	COG3266	domain, Protein
NIES4071_28110	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NIES4071_28160	COG0515	serine threonine protein kinase
NIES4071_28160	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_28260	COG0596	Alpha beta hydrolase
NIES4071_28270	COG1937	Protein conserved in bacteria
NIES4071_28280	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_28300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NIES4071_28390	COG2319	Wd-40 repeat
NIES4071_28390	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_28410	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_28410	COG0515	serine threonine protein kinase
NIES4071_28470	COG0038	chloride channel
NIES4071_28490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIES4071_28550	COG0154	amidase activity
NIES4071_28560	COG0587	DNA-directed DNA polymerase activity
NIES4071_28700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NIES4071_28740	COG0784	Response regulator, receiver
NIES4071_28750	COG0564	pseudouridine synthase activity
NIES4071_28770	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NIES4071_28780	COG1132	(ABC) transporter
NIES4071_28810	COG0367	asparagine synthase
NIES4071_28880	COG0367	asparagine synthase
NIES4071_28910	COG2850	peptidyl-arginine hydroxylation
NIES4071_28990	COG1091	dTDP-4-dehydrorhamnose reductase activity
NIES4071_29090	COG0297	glycogen (starch) synthase activity
NIES4071_29100	COG0438	transferase activity, transferring glycosyl groups
NIES4071_29110	COG0438	transferase activity, transferring glycosyl groups
NIES4071_29130	COG1215	transferase activity, transferring glycosyl groups
NIES4071_29140	COG1215	transferase activity, transferring glycosyl groups
NIES4071_29150	COG1216	Glycosyl transferase, family 2
NIES4071_29160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NIES4071_29220	COG0489	protein tyrosine kinase activity
NIES4071_29260	COG2264	protein methyltransferase activity
NIES4071_29270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NIES4071_29310	COG0572	uridine kinase
NIES4071_29440	COG1404	Belongs to the peptidase S8 family
NIES4071_29570	COG0484	heat shock protein binding
NIES4071_29620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NIES4071_29670	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_29670	COG5632	N-Acetylmuramoyl-L-alanine amidase
NIES4071_29690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NIES4071_29720	COG1012	belongs to the aldehyde dehydrogenase family
NIES4071_29740	COG2130	NADP-dependent
NIES4071_29810	COG0587	DNA-directed DNA polymerase activity
NIES4071_29820	COG0814	amino acid
NIES4071_29860	COG0346	lactoylglutathione lyase activity
NIES4071_29880	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_29940	COG3788	relative of glutathione S-transferase, MAPEG superfamily
NIES4071_29980	COG0346	lactoylglutathione lyase activity
NIES4071_30050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NIES4071_30060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NIES4071_30110	COG1819	glycosyl
NIES4071_30230	COG1131	(ABC) transporter
NIES4071_30290	COG0024	Methionine aminopeptidase
NIES4071_30320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NIES4071_30330	COG2814	Major facilitator Superfamily
NIES4071_30340	COG0438	transferase activity, transferring glycosyl groups
NIES4071_30350	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NIES4071_30360	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIES4071_30370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NIES4071_30410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NIES4071_30420	COG0751	glycine-tRNA ligase activity
NIES4071_30530	COG1475	DNA binding
NIES4071_30540	COG1192	Involved in chromosome partitioning
NIES4071_30650	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NIES4071_30660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_30670	COG0628	permease
NIES4071_30680	COG1051	belongs to the nudix hydrolase family
NIES4071_30720	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NIES4071_30790	COG0586	Pfam SNARE associated Golgi protein
NIES4071_30850	COG0686	Belongs to the AlaDH PNT family
NIES4071_30930	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES4071_30980	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NIES4071_31030	COG0316	Belongs to the HesB IscA family
NIES4071_31060	COG1090	epimerase
NIES4071_31090	COG2217	Heavy metal translocating P-type atpase
NIES4071_31150	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIES4071_31160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NIES4071_31190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES4071_31220	COG4585	Histidine kinase
NIES4071_31260	COG1271	oxidase subunit
NIES4071_31310	COG1657	PFAM Prenyltransferase squalene oxidase
NIES4071_31370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_31390	COG0129	dihydroxy-acid dehydratase activity
NIES4071_31400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NIES4071_31420	COG0004	ammonium transporteR
NIES4071_31430	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NIES4071_31460	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NIES4071_31470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NIES4071_31480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES4071_31500	COG2010	Cytochrome c
NIES4071_31570	COG1136	(ABC) transporter
NIES4071_31600	COG2234	aminopeptidase activity
NIES4071_31620	COG2192	nodulation
NIES4071_31630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIES4071_31650	COG1132	(ABC) transporter
NIES4071_31670	COG2197	response regulator
NIES4071_31700	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NIES4071_31720	COG0170	dolichyl monophosphate biosynthetic process
NIES4071_31770	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NIES4071_31790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES4071_31790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NIES4071_31870	COG0443	Heat shock 70 kDa protein
NIES4071_31900	COG5002	protein histidine kinase activity
NIES4071_31920	COG4451	ribulose bisphosphate carboxylase, small
NIES4071_31920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NIES4071_31950	COG3781	membrane
NIES4071_32070	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
NIES4071_32140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_32230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NIES4071_32260	COG3118	belongs to the thioredoxin family
NIES4071_32280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIES4071_32430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NIES4071_32550	COG0753	catalase activity
NIES4071_32650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIES4071_32770	COG1216	Glycosyl transferase, family 2
NIES4071_32790	COG0406	alpha-ribazole phosphatase activity
NIES4071_32830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIES4071_32890	COG5420	small protein containing a coiled-coil domain
NIES4071_32920	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_32930	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_32940	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_33040	COG1468	defense response to virus
NIES4071_33040	COG1518	maintenance of DNA repeat elements
NIES4071_33050	COG1518	maintenance of DNA repeat elements
NIES4071_33060	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NIES4071_33130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES4071_33150	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_33160	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_33170	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NIES4071_33190	COG2091	lysine biosynthetic process via aminoadipic acid
NIES4071_33240	COG2226	methyltransferase
NIES4071_33400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES4071_33410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES4071_33420	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NIES4071_33430	COG5592	hemerythrin HHE cation binding domain
NIES4071_33450	COG0848	biopolymer transport protein
NIES4071_33460	COG0811	peptide transport
NIES4071_33660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIES4071_33710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NIES4071_33750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIES4071_33760	COG0521	Mo-molybdopterin cofactor biosynthetic process
NIES4071_33790	COG0776	regulation of translation
NIES4071_33800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NIES4071_33820	COG2197	response regulator
NIES4071_33950	COG1132	(ABC) transporter
NIES4071_33980	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NIES4071_33980	COG2169	Transcriptional regulator
NIES4071_33990	COG2226	methyltransferase
NIES4071_34050	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NIES4071_34070	COG1024	Enoyl-CoA hydratase
NIES4071_34070	COG1250	3-hydroxyacyl-CoA dehydrogenase
NIES4071_34100	COG1902	pentaerythritol trinitrate reductase activity
NIES4071_34110	COG0583	DNA-binding transcription factor activity
NIES4071_34120	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_34140	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NIES4071_34150	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_34160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NIES4071_34320	COG2319	Wd-40 repeat
NIES4071_34320	COG3903	Transcriptional regulator
NIES4071_34330	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NIES4071_34400	COG0667	Aldo Keto reductase
NIES4071_34410	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_34420	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_34430	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_34450	COG0697	spore germination
NIES4071_34480	COG1902	pentaerythritol trinitrate reductase activity
NIES4071_34530	COG0583	DNA-binding transcription factor activity
NIES4071_34550	COG2249	NAD(P)H dehydrogenase (quinone) activity
NIES4071_34580	COG1309	transcriptional regulator
NIES4071_34620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIES4071_34650	COG0300	oxidoreductase activity
NIES4071_34720	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_34740	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_34760	COG0596	Alpha beta hydrolase
NIES4071_34820	COG3437	response regulator, receiver
NIES4071_34920	COG2319	Wd-40 repeat
NIES4071_34920	COG3903	Transcriptional regulator
NIES4071_34940	COG1902	pentaerythritol trinitrate reductase activity
NIES4071_34970	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_35030	COG1733	regulation of RNA biosynthetic process
NIES4071_35050	COG3706	GGDEF domain
NIES4071_35100	COG2832	Protein of unknown function (DUF454)
NIES4071_35130	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES4071_35140	COG0288	reversible hydration of carbon dioxide
NIES4071_35210	COG1475	DNA binding
NIES4071_35220	COG2217	Heavy metal translocating P-type atpase
NIES4071_35230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIES4071_35230	COG0515	serine threonine protein kinase
NIES4071_35260	COG0589	response to stress
NIES4071_35300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES4071_35320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES4071_35390	COG1216	Glycosyl transferase, family 2
NIES4071_35400	COG1216	Glycosyl transferase, family 2
NIES4071_35410	COG1132	(ABC) transporter
NIES4071_35420	COG1216	Glycosyl transferase, family 2
NIES4071_35440	COG2080	2 iron, 2 sulfur cluster binding
NIES4071_35450	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NIES4071_35460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIES4071_35470	COG4221	oxidoreductase activity
NIES4071_35490	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIES4071_35500	COG4585	Histidine kinase
NIES4071_35510	COG2197	response regulator
NIES4071_35550	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_35570	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_35630	COG1289	transmembrane transporter activity
NIES4071_35640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NIES4071_35670	COG1475	DNA binding
NIES4071_35780	COG0644	oxidoreductase
NIES4071_35850	COG0667	Aldo Keto reductase
NIES4071_35910	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NIES4071_35930	COG0667	Aldo Keto reductase
NIES4071_35960	COG4977	sequence-specific DNA binding
NIES4071_35960	COG1917	Cupin 2, conserved barrel domain protein
NIES4071_35980	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_35990	COG2207	Transcriptional regulator
NIES4071_36050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NIES4071_36060	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_36100	COG4221	oxidoreductase activity
NIES4071_36110	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_36120	COG0625	glutathione transferase activity
NIES4071_36310	COG5000	phosphorelay sensor kinase activity
NIES4071_36320	COG2205	protein histidine kinase activity
NIES4071_36330	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_36350	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_36390	COG2207	Transcriptional regulator
NIES4071_36410	COG0604	alcohol dehydrogenase
NIES4071_36420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIES4071_36430	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NIES4071_36440	COG2080	2 iron, 2 sulfur cluster binding
NIES4071_36480	COG0412	Dienelactone hydrolase
NIES4071_36610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIES4071_36650	COG0667	Aldo Keto reductase
NIES4071_36660	COG0724	RNA recognition motif
NIES4071_36860	COG1222	aaa ATPase
NIES4071_36960	COG0154	amidase activity
NIES4071_36980	COG0288	reversible hydration of carbon dioxide
NIES4071_36990	COG1720	tRNA m6t6A37 methyltransferase activity
NIES4071_37080	COG4251	negative regulation of phosphorylation
NIES4071_37090	COG4251	negative regulation of phosphorylation
NIES4071_37100	COG0784	Response regulator, receiver
NIES4071_37110	COG2205	protein histidine kinase activity
NIES4071_37230	COG3386	PFAM SMP-30 Gluconolaconase
NIES4071_37240	COG0675	Transposase, IS605 OrfB family
NIES4071_37330	COG0454	-acetyltransferase
NIES4071_37330	COG0456	acetyltransferase
NIES4071_37360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_37370	COG3266	domain, Protein
NIES4071_37370	COG0515	serine threonine protein kinase
NIES4071_37420	COG1131	(ABC) transporter
NIES4071_37430	COG0842	Transport permease protein
NIES4071_37430	COG1129	ABC transporter
NIES4071_37440	COG0842	Transport permease protein
NIES4071_37460	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_37650	COG0243	molybdopterin cofactor binding
NIES4071_37670	COG0784	Response regulator, receiver
NIES4071_37680	COG4251	negative regulation of phosphorylation
NIES4071_37740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NIES4071_37770	COG0515	serine threonine protein kinase
NIES4071_37770	COG3266	domain, Protein
NIES4071_37780	COG2319	Wd-40 repeat
NIES4071_37780	COG5635	Nacht domain
NIES4071_37800	COG0788	formyltetrahydrofolate deformylase activity
NIES4071_37810	COG0788	formyltetrahydrofolate deformylase activity
NIES4071_37820	COG4221	oxidoreductase activity
NIES4071_37830	COG4310	Domain of unknown function (DUF2172)
NIES4071_37840	COG2832	Protein of unknown function (DUF454)
NIES4071_37860	COG2234	aminopeptidase activity
NIES4071_37880	COG0667	Aldo Keto reductase
NIES4071_37910	COG1196	nuclear chromosome segregation
NIES4071_37910	COG0741	lytic transglycosylase activity
NIES4071_37910	COG0739	heme binding
NIES4071_37920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NIES4071_37920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NIES4071_37930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIES4071_37960	COG0515	serine threonine protein kinase
NIES4071_37960	COG3064	Membrane
NIES4071_37960	COG4991	sh3 domain protein
NIES4071_38040	COG0402	S-adenosylhomocysteine deaminase activity
NIES4071_38110	COG2124	cytochrome p450
NIES4071_38120	COG2124	cytochrome p450
NIES4071_38160	COG0300	oxidoreductase activity
NIES4071_38170	COG2124	cytochrome p450
NIES4071_38190	COG4948	Mandelate Racemase Muconate Lactonizing
NIES4071_38230	COG0726	polysaccharide deacetylase
NIES4071_38240	COG2166	iron-sulfur cluster assembly
NIES4071_38260	COG0523	cobalamin synthesis protein
NIES4071_38300	COG0803	Belongs to the bacterial solute-binding protein 9 family
NIES4071_38360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NIES4071_38370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_38400	COG1160	GTP binding
NIES4071_38490	COG3585	molybdate ion transport
NIES4071_38500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_38510	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_38520	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_38560	COG2146	nitrite reductase [NAD(P)H] activity
NIES4071_38560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIES4071_38660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIES4071_38680	COG2815	serine threonine protein kinase
NIES4071_38680	COG0515	serine threonine protein kinase
NIES4071_38720	COG0697	spore germination
NIES4071_38740	COG1280	lysine exporter protein (LysE YggA)
NIES4071_38790	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_38860	COG0438	transferase activity, transferring glycosyl groups
NIES4071_38900	COG0793	Belongs to the peptidase S41A family
NIES4071_38990	COG2211	Major facilitator Superfamily
NIES4071_39000	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
NIES4071_39050	COG5002	protein histidine kinase activity
NIES4071_39070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_39080	COG4191	Histidine kinase
NIES4071_39080	COG0784	Response regulator, receiver
NIES4071_39140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NIES4071_39160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NIES4071_39180	COG5002	protein histidine kinase activity
NIES4071_39190	COG0745	RESPONSE REGULATOR receiver
NIES4071_39200	COG0745	RESPONSE REGULATOR receiver
NIES4071_39250	COG0189	ligase activity
NIES4071_39250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NIES4071_39290	COG1254	Belongs to the acylphosphatase family
NIES4071_39300	COG0024	Methionine aminopeptidase
NIES4071_39310	COG0612	Peptidase, M16
NIES4071_39360	COG0285	dihydrofolate synthase activity
NIES4071_39540	COG0523	cobalamin synthesis protein
NIES4071_39570	COG0312	modulator of DNA gyrase
NIES4071_39750	COG2161	toxin-antitoxin pair type II binding
NIES4071_39760	COG4115	mRNA cleavage
NIES4071_39780	COG2814	Major facilitator Superfamily
NIES4071_39830	COG0574	Belongs to the PEP-utilizing enzyme family
NIES4071_39830	COG3848	Pyruvate phosphate dikinase
NIES4071_39870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES4071_39880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES4071_39890	COG1116	anion transmembrane transporter activity
NIES4071_39890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES4071_39900	COG1116	anion transmembrane transporter activity
NIES4071_39930	COG1162	GTPase activity
NIES4071_39960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES4071_39970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES4071_39980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES4071_39990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES4071_40020	COG1252	NADH dehydrogenase
NIES4071_40040	COG1674	ftsk spoiiie
NIES4071_40130	COG2076	Multidrug Resistance protein
NIES4071_40150	COG0438	transferase activity, transferring glycosyl groups
NIES4071_40170	COG1881	PFAM PEBP family protein
NIES4071_40200	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_40250	COG1309	transcriptional regulator
NIES4071_40290	COG0392	lysyltransferase activity
NIES4071_40290	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NIES4071_40340	COG0392	lysyltransferase activity
NIES4071_40360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIES4071_40380	COG0384	phenazine biosynthesis protein PhzF
NIES4071_40390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_40390	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NIES4071_40400	COG1562	ergosterol biosynthetic process
NIES4071_40430	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NIES4071_40480	COG0489	protein tyrosine kinase activity
NIES4071_40550	COG0791	NLP P60 protein
NIES4071_40560	COG0463	Glycosyl transferase, family 2
NIES4071_40570	COG2814	Major facilitator Superfamily
NIES4071_40590	COG0315	cyclic pyranopterin monophosphate synthase activity
NIES4071_40710	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_40720	COG1741	Belongs to the pirin family
NIES4071_40730	COG0783	Belongs to the Dps family
NIES4071_40750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NIES4071_40760	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NIES4071_40760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NIES4071_40780	COG4178	(ABC) transporter
NIES4071_40840	COG4336	lyase activity
NIES4071_40850	COG4581	dead DEAH box helicase
NIES4071_40860	COG0515	serine threonine protein kinase
NIES4071_40950	COG0123	including yeast histone deacetylase and acetoin utilization protein
NIES4071_40970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIES4071_40980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NIES4071_41090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIES4071_41100	COG0753	catalase activity
NIES4071_41100	COG0693	protein deglycase activity
NIES4071_41130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NIES4071_41150	COG0038	chloride channel
NIES4071_41170	COG1959	2 iron, 2 sulfur cluster binding
NIES4071_41180	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NIES4071_41190	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NIES4071_41230	COG0784	Response regulator, receiver
NIES4071_41240	COG4251	negative regulation of phosphorylation
NIES4071_41260	COG0314	molybdopterin synthase activity
NIES4071_41330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES4071_41350	COG2119	membrane
NIES4071_41420	COG1566	PFAM secretion protein HlyD family protein
NIES4071_41440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIES4071_41470	COG1672	PFAM Archaeal ATPase
NIES4071_41480	COG1305	Transglutaminase-like
NIES4071_41490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES4071_41500	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_41520	COG0574	Belongs to the PEP-utilizing enzyme family
NIES4071_41520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIES4071_41560	COG3659	wide pore channel activity
NIES4071_41570	COG0793	Belongs to the peptidase S41A family
NIES4071_41580	COG4585	Histidine kinase
NIES4071_41590	COG2197	response regulator
NIES4071_41730	COG2319	Wd-40 repeat
NIES4071_41730	COG1672	PFAM Archaeal ATPase
NIES4071_41800	COG3344	reverse transcriptase
NIES4071_41870	COG4467	Involved in initiation control of chromosome replication
NIES4071_41930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NIES4071_41940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NIES4071_41950	COG0123	including yeast histone deacetylase and acetoin utilization protein
NIES4071_42120	COG3850	Histidine kinase
NIES4071_42120	COG3437	response regulator, receiver
NIES4071_42120	COG2205	protein histidine kinase activity
NIES4071_42120	COG4999	Histidine kinase
NIES4071_42170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIES4071_42300	COG2084	Dehydrogenase
NIES4071_42330	COG5001	Diguanylate cyclase
NIES4071_42340	COG0649	NAD binding
NIES4071_42360	COG3437	response regulator, receiver
NIES4071_42360	COG3850	Histidine kinase
NIES4071_42360	COG4999	Histidine kinase
NIES4071_42360	COG2205	protein histidine kinase activity
NIES4071_42370	COG2205	protein histidine kinase activity
NIES4071_42370	COG5002	protein histidine kinase activity
NIES4071_42370	COG0784	Response regulator, receiver
NIES4071_42400	COG2201	protein-glutamate methylesterase activity
NIES4071_42600	COG0300	oxidoreductase activity
NIES4071_42620	COG0513	Belongs to the DEAD box helicase family
NIES4071_42690	COG0438	transferase activity, transferring glycosyl groups
NIES4071_42730	COG1475	DNA binding
NIES4071_42750	COG3321	synthase
NIES4071_42750	COG0604	alcohol dehydrogenase
NIES4071_42770	COG3321	synthase
NIES4071_42770	COG4221	oxidoreductase activity
NIES4071_42770	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_42770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIES4071_42790	COG2070	2-Nitropropane dioxygenase
NIES4071_42790	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NIES4071_42800	COG3320	Male sterility
NIES4071_42800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIES4071_42840	COG2091	lysine biosynthetic process via aminoadipic acid
NIES4071_42900	COG3546	catalase activity
NIES4071_42920	COG0477	Major facilitator Superfamily
NIES4071_43030	COG4191	Histidine kinase
NIES4071_43030	COG0745	RESPONSE REGULATOR receiver
NIES4071_43030	COG2205	protein histidine kinase activity
NIES4071_43040	COG4106	trans-aconitate 2-methyltransferase activity
NIES4071_43100	COG2319	Wd-40 repeat
NIES4071_43100	COG3903	Transcriptional regulator
NIES4071_43120	COG4977	sequence-specific DNA binding
NIES4071_43320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES4071_43330	COG1136	(ABC) transporter
NIES4071_43330	COG0577	efflux transmembrane transporter activity
NIES4071_43510	COG1785	Belongs to the alkaline phosphatase family
NIES4071_43640	COG0464	growth
NIES4071_43670	COG3757	hydrolase, family 25
NIES4071_43670	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_43680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIES4071_43690	COG0435	Glutathione S-transferase
NIES4071_43790	COG0515	serine threonine protein kinase
NIES4071_43790	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_43800	COG0515	serine threonine protein kinase
NIES4071_43800	COG3266	domain, Protein
NIES4071_43920	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
NIES4071_43940	COG4245	von Willebrand factor, type A
NIES4071_44030	COG3757	hydrolase, family 25
NIES4071_44100	COG3903	Transcriptional regulator
NIES4071_44100	COG2319	Wd-40 repeat
NIES4071_44120	COG2319	Wd-40 repeat
NIES4071_44120	COG3903	Transcriptional regulator
NIES4071_44130	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES4071_44300	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIES4071_44330	COG0515	serine threonine protein kinase
NIES4071_44380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_44460	COG1177	transmembrane transport
NIES4071_44520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIES4071_44570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NIES4071_44610	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_44620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES4071_44640	COG1215	transferase activity, transferring glycosyl groups
NIES4071_44670	COG1215	transferase activity, transferring glycosyl groups
NIES4071_44680	COG0438	transferase activity, transferring glycosyl groups
NIES4071_44740	COG2442	InterPro IPR007367
NIES4071_44810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIES4071_44830	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NIES4071_44890	COG3977	Valine--pyruvate aminotransferase
NIES4071_44900	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NIES4071_44950	COG0625	glutathione transferase activity
NIES4071_44980	COG0625	glutathione transferase activity
NIES4071_45000	COG0559	Belongs to the binding-protein-dependent transport system permease family
NIES4071_45020	COG0411	ABC transporter
NIES4071_45030	COG0410	ABC transporter
NIES4071_45040	COG2124	cytochrome p450
NIES4071_45080	COG2319	Wd-40 repeat
NIES4071_45080	COG1672	PFAM Archaeal ATPase
NIES4071_45100	COG0837	glucose binding
NIES4071_45160	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
NIES4071_45190	COG2201	protein-glutamate methylesterase activity
NIES4071_45200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIES4071_45210	COG5002	protein histidine kinase activity
NIES4071_45240	COG1132	(ABC) transporter
NIES4071_45280	COG0667	Aldo Keto reductase
NIES4071_45310	COG0583	DNA-binding transcription factor activity
NIES4071_45450	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIES4071_45470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NIES4071_45480	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NIES4071_45490	COG2080	2 iron, 2 sulfur cluster binding
NIES4071_45510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIES4071_45540	COG1324	tolerance protein
NIES4071_45670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NIES4071_45680	COG0750	zinc metalloprotease
NIES4071_45690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIES4071_45750	COG0596	Alpha beta hydrolase
NIES4071_45780	COG4251	negative regulation of phosphorylation
NIES4071_45870	COG2815	serine threonine protein kinase
NIES4071_45870	COG0515	serine threonine protein kinase
NIES4071_45890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES4071_45910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NIES4071_45920	COG1122	ATPase activity
NIES4071_45950	COG1120	ATPase activity
NIES4071_45960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES4071_46010	COG0745	RESPONSE REGULATOR receiver
NIES4071_46030	COG4467	Involved in initiation control of chromosome replication
NIES4071_46050	COG5002	protein histidine kinase activity
NIES4071_46050	COG0784	Response regulator, receiver
NIES4071_46080	COG0739	heme binding
NIES4071_46200	COG1266	CAAX protease self-immunity
NIES4071_46220	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_46240	COG1309	transcriptional regulator
NIES4071_46290	COG0640	Transcriptional regulator
NIES4071_46370	COG1070	Carbohydrate kinase
NIES4071_46380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NIES4071_46390	COG3903	Transcriptional regulator
NIES4071_46390	COG2319	Wd-40 repeat
NIES4071_46420	COG0163	prenyltransferase activity
NIES4071_46430	COG0557	exoribonuclease II activity
NIES4071_46460	COG1331	Highly conserved protein containing a thioredoxin domain
NIES4071_46470	COG0746	molybdenum cofactor guanylyltransferase activity
NIES4071_46480	COG0440	acetolactate synthase activity
NIES4071_46500	COG0728	peptidoglycan biosynthetic process
NIES4071_46510	COG1215	transferase activity, transferring glycosyl groups
NIES4071_46570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES4071_46590	COG1181	Belongs to the D-alanine--D-alanine ligase family
NIES4071_46620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIES4071_46650	COG0438	transferase activity, transferring glycosyl groups
NIES4071_46690	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NIES4071_46710	COG1569	PIN domain
NIES4071_46720	COG3311	Transcriptional regulator
NIES4071_46760	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NIES4071_46860	COG0438	transferase activity, transferring glycosyl groups
NIES4071_46880	COG0501	Belongs to the peptidase M48B family
NIES4071_46890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NIES4071_46910	COG0113	porphobilinogen synthase activity
NIES4071_46960	COG2217	Heavy metal translocating P-type atpase
NIES4071_46970	COG0515	serine threonine protein kinase
NIES4071_47070	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NIES4071_47110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NIES4071_47190	COG0343	queuine tRNA-ribosyltransferase activity
NIES4071_47230	COG0589	response to stress
NIES4071_47270	COG0339	signal peptide processing
NIES4071_47280	COG2843	Capsule synthesis protein
NIES4071_47340	COG1672	PFAM Archaeal ATPase
NIES4071_47340	COG2319	Wd-40 repeat
NIES4071_47500	COG0542	response to heat
NIES4071_47560	COG0180	Tryptophanyl-tRNA synthetase
NIES4071_47570	COG0646	methionine synthase
NIES4071_47570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NIES4071_47780	COG0515	serine threonine protein kinase
NIES4071_47780	COG3266	domain, Protein
NIES4071_47790	COG0515	serine threonine protein kinase
NIES4071_47790	COG3266	domain, Protein
NIES4071_47830	COG0589	response to stress
NIES4071_47850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NIES4071_47880	COG0085	RNA polymerase activity
NIES4071_47890	COG0084	hydrolase, TatD family'
NIES4071_47900	COG0268	Binds directly to 16S ribosomal RNA
NIES4071_47950	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NIES4071_47970	COG1215	transferase activity, transferring glycosyl groups
NIES4071_48070	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIES4071_48120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NIES4071_48170	COG1203	CRISPR-associated helicase, Cas3
NIES4071_48320	COG0667	Aldo Keto reductase
NIES4071_48350	COG0435	Glutathione S-transferase
NIES4071_48380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIES4071_48390	COG0457	Tetratricopeptide repeat
NIES4071_48400	COG2135	peptidase activity
NIES4071_48410	COG0625	glutathione transferase activity
NIES4071_48460	COG5592	hemerythrin HHE cation binding domain
NIES4071_48470	COG1473	amidohydrolase
NIES4071_48490	COG5002	protein histidine kinase activity
NIES4071_48490	COG2198	Histidine kinase
NIES4071_48490	COG0784	Response regulator, receiver
NIES4071_48520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIES4071_48540	COG0515	serine threonine protein kinase
NIES4071_48540	COG3266	domain, Protein
NIES4071_48560	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_48580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES4071_48600	COG4399	Belongs to the UPF0754 family
NIES4071_48630	COG2204	response regulator
NIES4071_48660	COG1074	ATP-dependent DNA helicase activity
NIES4071_48670	COG2205	protein histidine kinase activity
NIES4071_48670	COG0784	Response regulator, receiver
NIES4071_48700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_48750	COG0398	Pfam SNARE associated Golgi protein
NIES4071_48760	COG0463	Glycosyl transferase, family 2
NIES4071_48810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NIES4071_48820	COG0784	Response regulator, receiver
NIES4071_48820	COG5002	protein histidine kinase activity
NIES4071_48840	COG0501	Belongs to the peptidase M48B family
NIES4071_48900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NIES4071_48940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_48980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NIES4071_49010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIES4071_49050	COG0574	Belongs to the PEP-utilizing enzyme family
NIES4071_49050	COG3848	Pyruvate phosphate dikinase
NIES4071_49090	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_49110	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NIES4071_49130	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES4071_49140	COG2003	Belongs to the UPF0758 family
NIES4071_49160	COG0572	uridine kinase
NIES4071_49250	COG1819	glycosyl
NIES4071_49490	COG2319	Wd-40 repeat
NIES4071_49490	COG5635	Nacht domain
NIES4071_49600	COG1773	rubredoxin
NIES4071_49600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES4071_49620	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NIES4071_49630	COG2894	cell division
NIES4071_49640	COG0850	regulation of cytokinetic process
NIES4071_49710	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES4071_49770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES4071_49790	COG3548	integral membrane protein
NIES4071_49800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_49820	COG0583	DNA-binding transcription factor activity
NIES4071_49830	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NIES4071_49870	COG0514	ATP-dependent DNA helicase (RecQ)
NIES4071_49930	COG2319	Wd-40 repeat
NIES4071_49930	COG1672	PFAM Archaeal ATPase
NIES4071_49950	COG0515	serine threonine protein kinase
NIES4071_49950	COG2815	serine threonine protein kinase
NIES4071_49960	COG0515	serine threonine protein kinase
NIES4071_49960	COG3266	domain, Protein
NIES4071_49970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NIES4071_50010	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
NIES4071_50020	COG2211	Major facilitator Superfamily
NIES4071_50060	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES4071_50070	COG1494	fructose-1,6-bisphosphatase
NIES4071_50120	COG0484	heat shock protein binding
NIES4071_50140	COG0740	serine-type endopeptidase activity
NIES4071_50150	COG2304	oxidoreductase activity
NIES4071_50160	COG0346	lactoylglutathione lyase activity
NIES4071_50190	COG0632	four-way junction helicase activity
NIES4071_50200	COG0561	phosphatase activity
NIES4071_50230	COG1722	exodeoxyribonuclease VII activity
NIES4071_50250	COG1570	exodeoxyribonuclease VII activity
NIES4071_50260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NIES4071_50290	COG2363	Small membrane protein
NIES4071_50320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_50330	COG1566	PFAM secretion protein HlyD family protein
NIES4071_50340	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NIES4071_50350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NIES4071_50360	COG0438	transferase activity, transferring glycosyl groups
NIES4071_50380	COG0438	transferase activity, transferring glycosyl groups
NIES4071_50400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_50520	COG2319	Wd-40 repeat
NIES4071_50520	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_50540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_50620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_50690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_50710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_50760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NIES4071_50770	COG1006	Multisubunit Na H antiporter MnhC subunit
NIES4071_50780	COG0651	ATP synthesis coupled electron transport
NIES4071_50890	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_50910	COG2197	response regulator
NIES4071_50920	COG1566	PFAM secretion protein HlyD family protein
NIES4071_50930	COG0753	catalase activity
NIES4071_50940	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_50960	COG4585	Histidine kinase
NIES4071_50970	COG2197	response regulator
NIES4071_51030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIES4071_51030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIES4071_51040	COG1335	isochorismatase
NIES4071_51070	COG0784	Response regulator, receiver
NIES4071_51070	COG2205	protein histidine kinase activity
NIES4071_51090	COG1376	ErfK ybiS ycfS ynhG family protein
NIES4071_51100	COG0748	coenzyme F420 binding
NIES4071_51110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_51120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_51130	COG2197	response regulator
NIES4071_51190	COG4804	nuclease activity
NIES4071_51220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NIES4071_51230	COG1349	DNA-binding transcription factor activity
NIES4071_51270	COG2226	methyltransferase
NIES4071_51320	COG0724	RNA recognition motif
NIES4071_51330	COG1132	(ABC) transporter
NIES4071_51400	COG2244	polysaccharide biosynthetic process
NIES4071_51430	COG0297	glycogen (starch) synthase activity
NIES4071_51440	COG1216	Glycosyl transferase, family 2
NIES4071_51440	COG0463	Glycosyl transferase, family 2
NIES4071_51450	COG1216	Glycosyl transferase, family 2
NIES4071_51450	COG0463	Glycosyl transferase, family 2
NIES4071_51490	COG1216	Glycosyl transferase, family 2
NIES4071_51490	COG0463	Glycosyl transferase, family 2
NIES4071_51560	COG5002	protein histidine kinase activity
NIES4071_51600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES4071_51620	COG5002	protein histidine kinase activity
NIES4071_51630	COG5002	protein histidine kinase activity
NIES4071_51680	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_51690	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_51730	COG3238	Protein conserved in bacteria
NIES4071_51880	COG0409	Hydrogenase expression formation protein
NIES4071_51970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NIES4071_52040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NIES4071_52110	COG0515	serine threonine protein kinase
NIES4071_52110	COG2815	serine threonine protein kinase
NIES4071_52170	COG2807	transmembrane transport
NIES4071_52200	COG1192	Involved in chromosome partitioning
NIES4071_52330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NIES4071_52360	COG2814	Major facilitator Superfamily
NIES4071_52570	COG2319	Wd-40 repeat
NIES4071_52570	COG1672	PFAM Archaeal ATPase
NIES4071_52660	COG0525	valine-tRNA ligase activity
NIES4071_52720	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES4071_52730	COG0497	DNA recombination
NIES4071_52790	COG3852	Histidine kinase
NIES4071_52800	COG0701	Predicted permease
NIES4071_52890	COG0702	epimerase
NIES4071_52900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NIES4071_52920	COG1797	cobyrinic acid a,c-diamide synthase activity
NIES4071_52930	COG3429	Glucose-6-phosphate dehydrogenase subunit
NIES4071_52930	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_52940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NIES4071_52950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIES4071_52970	COG0724	RNA recognition motif
NIES4071_53120	COG1045	serine acetyltransferase
NIES4071_53150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIES4071_53210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES4071_53240	COG2124	cytochrome p450
NIES4071_53280	COG2223	nitrite transmembrane transporter activity
NIES4071_53310	COG1201	RNA secondary structure unwinding
NIES4071_53330	COG0671	phosphoesterase, PA-phosphatase related
NIES4071_53450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NIES4071_53560	COG2831	hemolysin activation secretion protein
NIES4071_53570	COG2244	polysaccharide biosynthetic process
NIES4071_53580	COG1045	serine acetyltransferase
NIES4071_53590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIES4071_53600	COG0678	peroxiredoxin activity
NIES4071_53630	COG2319	Wd-40 repeat
NIES4071_53630	COG1672	PFAM Archaeal ATPase
NIES4071_53790	COG1216	Glycosyl transferase, family 2
NIES4071_53890	COG0501	Belongs to the peptidase M48B family
NIES4071_53940	COG0824	Thioesterase
NIES4071_53980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NIES4071_54000	COG0792	nuclease activity
NIES4071_54020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NIES4071_54060	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_54060	COG3321	synthase
NIES4071_54060	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_54060	COG0300	oxidoreductase activity
NIES4071_54060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIES4071_54130	COG3773	Cell wall hydrolase
NIES4071_54130	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_54160	COG0569	domain protein
NIES4071_54170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NIES4071_54180	COG2226	methyltransferase
NIES4071_54190	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES4071_54270	COG3657	addiction module killer protein
NIES4071_54290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIES4071_54340	COG4636	protein conserved in cyanobacteria
NIES4071_54360	COG4636	protein conserved in cyanobacteria
NIES4071_54390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIES4071_54450	COG0745	RESPONSE REGULATOR receiver
NIES4071_54460	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIES4071_54520	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NIES4071_54530	COG4783	chaperone-mediated protein folding
NIES4071_54590	COG2385	sporulation resulting in formation of a cellular spore
NIES4071_54620	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES4071_54630	COG0745	RESPONSE REGULATOR receiver
NIES4071_54690	COG2204	response regulator
NIES4071_54760	COG2319	Wd-40 repeat
NIES4071_54760	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_54840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NIES4071_54850	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIES4071_54860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NIES4071_54880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIES4071_54890	COG0356	it plays a direct role in the translocation of protons across the membrane
NIES4071_54910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_54960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES4071_54960	COG0237	dephospho-CoA kinase activity
NIES4071_55010	COG0772	Belongs to the SEDS family
NIES4071_55060	COG1333	cytochrome c biogenesis protein
NIES4071_55090	COG3240	lipase activity
NIES4071_55120	COG0826	peptidase U32
NIES4071_55140	COG2197	response regulator
NIES4071_55150	COG2205	protein histidine kinase activity
NIES4071_55170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NIES4071_55180	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NIES4071_55200	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
NIES4071_55210	COG2205	protein histidine kinase activity
NIES4071_55310	COG1085	galactose-1-phosphate uridylyltransferase
NIES4071_55460	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_55490	COG0154	amidase activity
NIES4071_55500	COG0154	amidase activity
NIES4071_55520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES4071_55530	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NIES4071_55550	COG0505	Belongs to the CarA family
NIES4071_55610	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES4071_55630	COG2205	protein histidine kinase activity
NIES4071_55640	COG2197	response regulator
NIES4071_55660	COG3706	GGDEF domain
NIES4071_55660	COG0745	RESPONSE REGULATOR receiver
NIES4071_55680	COG0436	Aminotransferase
NIES4071_55690	COG3118	belongs to the thioredoxin family
NIES4071_55740	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_55840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES4071_55920	COG0646	methionine synthase
NIES4071_55920	COG1410	methionine synthase
NIES4071_56020	COG1836	PFAM Integral membrane protein DUF92
NIES4071_56060	COG1404	Belongs to the peptidase S8 family
NIES4071_56120	COG0438	transferase activity, transferring glycosyl groups
NIES4071_56140	COG1063	alcohol dehydrogenase
NIES4071_56180	COG1842	Phage shock protein A
NIES4071_56190	COG1842	Phage shock protein A
NIES4071_56260	COG4106	trans-aconitate 2-methyltransferase activity
NIES4071_56280	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NIES4071_56290	COG5002	protein histidine kinase activity
NIES4071_56290	COG3447	MASE1 domain protein
NIES4071_56290	COG5001	Diguanylate cyclase
NIES4071_56380	COG1032	radical SAM domain protein
NIES4071_56390	COG0724	RNA recognition motif
NIES4071_56480	COG2084	Dehydrogenase
NIES4071_56530	COG5002	protein histidine kinase activity
NIES4071_56550	COG4251	negative regulation of phosphorylation
NIES4071_56560	COG1716	ATPase activity
NIES4071_56570	COG0784	Response regulator, receiver
NIES4071_56620	COG4999	Histidine kinase
NIES4071_56620	COG2205	protein histidine kinase activity
NIES4071_56620	COG3437	response regulator, receiver
NIES4071_56620	COG3850	Histidine kinase
NIES4071_56680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NIES4071_56690	COG1404	Belongs to the peptidase S8 family
NIES4071_56720	COG0235	Class ii aldolase
NIES4071_56750	COG0863	Belongs to the N(4) N(6)-methyltransferase family
NIES4071_56800	COG2255	four-way junction helicase activity
NIES4071_56850	COG2124	cytochrome p450
NIES4071_56860	COG0312	modulator of DNA gyrase
NIES4071_56910	COG2205	protein histidine kinase activity
NIES4071_57000	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES4071_57010	COG0297	glycogen (starch) synthase activity
NIES4071_57020	COG0287	Prephenate dehydrogenase
NIES4071_57020	COG1605	Chorismate mutase
NIES4071_57030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIES4071_57060	COG0512	Glutamine amidotransferase of anthranilate synthase
NIES4071_57060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES4071_57070	COG0134	indole-3-glycerol-phosphate synthase activity
NIES4071_57090	COG0133	tryptophan synthase activity
NIES4071_57100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIES4071_57110	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NIES4071_57160	COG0488	(ABC) transporter
NIES4071_57210	COG0535	radical SAM domain protein
NIES4071_57230	COG1309	transcriptional regulator
NIES4071_57240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NIES4071_57240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NIES4071_57310	COG2197	response regulator
NIES4071_57330	COG2124	cytochrome p450
NIES4071_57340	COG1819	glycosyl
NIES4071_57370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_57390	COG0724	RNA recognition motif
NIES4071_57450	COG0577	efflux transmembrane transporter activity
NIES4071_57450	COG1136	(ABC) transporter
NIES4071_57460	COG3240	lipase activity
NIES4071_57470	COG2319	Wd-40 repeat
NIES4071_57470	COG3903	Transcriptional regulator
NIES4071_57480	COG2124	cytochrome p450
NIES4071_57610	COG1233	COG1233 Phytoene dehydrogenase and related
NIES4071_57670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NIES4071_57720	COG2226	methyltransferase
NIES4071_57730	COG1690	Belongs to the RtcB family
NIES4071_57730	COG1690	Belongs to the RtcB family
NIES4071_57760	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NIES4071_57800	COG2326	polyphosphate kinase activity
NIES4071_57910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NIES4071_57920	COG0488	(ABC) transporter
NIES4071_57960	COG0515	serine threonine protein kinase
NIES4071_57990	COG0477	Major facilitator Superfamily
NIES4071_58140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NIES4071_58180	COG0101	tRNA pseudouridine synthase activity
NIES4071_58240	COG0563	adenylate kinase activity
NIES4071_58250	COG0201	protein transport
NIES4071_58260	COG0200	Binds to the 23S rRNA
NIES4071_58300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NIES4071_58310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NIES4071_58370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NIES4071_58390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NIES4071_58400	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NIES4071_58410	COG0089	rRNA binding
NIES4071_58420	COG0088	Forms part of the polypeptide exit tunnel
NIES4071_58480	COG0475	glutathione-regulated potassium exporter activity
NIES4071_58490	COG0475	glutathione-regulated potassium exporter activity
NIES4071_58500	COG0515	serine threonine protein kinase
NIES4071_58620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NIES4071_58630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NIES4071_58690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_58690	COG4191	Histidine kinase
NIES4071_58700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NIES4071_58710	COG1960	acyl-CoA dehydrogenase activity
NIES4071_58740	COG2340	Cysteine-rich secretory protein family
NIES4071_58750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NIES4071_58970	COG0166	Belongs to the GPI family
NIES4071_59030	COG0411	ABC transporter
NIES4071_59040	COG0410	ABC transporter
NIES4071_59100	COG0300	oxidoreductase activity
NIES4071_59100	COG3000	fatty acid hydroxylase
NIES4071_59190	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES4071_59240	COG1943	Transposase
NIES4071_59340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NIES4071_59350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIES4071_59380	COG1252	NADH dehydrogenase
NIES4071_59410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NIES4071_59430	COG0667	Aldo Keto reductase
NIES4071_59460	COG1064	alcohol dehydrogenase
NIES4071_59470	COG2207	Transcriptional regulator
NIES4071_59490	COG0025	NhaP-type Na H and K H
NIES4071_59550	COG1609	Transcriptional regulator
NIES4071_59560	COG0667	Aldo Keto reductase
NIES4071_59640	COG3932	Exopolysaccharide synthesis, ExoD
NIES4071_59650	COG0726	polysaccharide deacetylase
NIES4071_59680	COG0515	serine threonine protein kinase
NIES4071_59700	COG0204	Acyl-transferase
NIES4071_59700	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_59710	COG0628	permease
NIES4071_59760	COG0484	heat shock protein binding
NIES4071_59780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_59810	COG0741	lytic transglycosylase activity
NIES4071_59840	COG2319	Wd-40 repeat
NIES4071_59840	COG5635	Nacht domain
NIES4071_59870	COG0515	serine threonine protein kinase
NIES4071_59870	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_59910	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NIES4071_59910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES4071_59920	COG3437	response regulator, receiver
NIES4071_59930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NIES4071_59940	COG1446	asparaginase
NIES4071_59970	COG0167	dihydroorotate dehydrogenase activity
NIES4071_60060	COG2304	oxidoreductase activity
NIES4071_60070	COG1487	ribonuclease activity
NIES4071_60120	COG0464	growth
NIES4071_60130	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_60130	COG2319	Wd-40 repeat
NIES4071_60140	COG0270	DNA (cytosine-5-)-methyltransferase activity
NIES4071_60160	COG1943	Transposase
NIES4071_60180	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIES4071_60300	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIES4071_60340	COG0768	penicillin binding
NIES4071_60350	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
NIES4071_60380	COG0484	heat shock protein binding
NIES4071_60400	COG2239	Acts as a magnesium transporter
NIES4071_60480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NIES4071_60520	COG0463	Glycosyl transferase, family 2
NIES4071_60550	COG0436	Aminotransferase
NIES4071_60560	COG0371	Dehydrogenase
NIES4071_60650	COG3781	membrane
NIES4071_60710	COG4636	protein conserved in cyanobacteria
NIES4071_60720	COG2234	aminopeptidase activity
NIES4071_60730	COG0443	Heat shock 70 kDa protein
NIES4071_60740	COG0484	heat shock protein binding
NIES4071_60750	COG0484	heat shock protein binding
NIES4071_60770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NIES4071_60780	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NIES4071_60800	COG0019	diaminopimelate decarboxylase activity
NIES4071_60820	COG0542	response to heat
NIES4071_60860	COG0681	Belongs to the peptidase S26 family
NIES4071_60900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NIES4071_60910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NIES4071_61020	COG0805	protein transport
NIES4071_61160	COG2319	Wd-40 repeat
NIES4071_61160	COG2319	Wd-40 repeat
NIES4071_61160	COG1672	PFAM Archaeal ATPase
NIES4071_61160	COG1672	PFAM Archaeal ATPase
NIES4071_61200	COG0300	oxidoreductase activity
NIES4071_61290	COG1012	belongs to the aldehyde dehydrogenase family
NIES4071_61320	COG2205	protein histidine kinase activity
NIES4071_61330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NIES4071_61360	COG2200	EAL domain
NIES4071_61360	COG2199	diguanylate cyclase activity
NIES4071_61380	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES4071_61400	COG0483	inositol monophosphate 1-phosphatase activity
NIES4071_61410	COG0484	heat shock protein binding
NIES4071_61420	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NIES4071_61430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_61500	COG2319	Wd-40 repeat
NIES4071_61500	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_61550	COG2814	Major facilitator Superfamily
NIES4071_61610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_61890	COG0259	pyridoxamine-phosphate oxidase activity
NIES4071_61900	COG0628	permease
NIES4071_61920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES4071_61940	COG0745	RESPONSE REGULATOR receiver
NIES4071_61950	COG2205	protein histidine kinase activity
NIES4071_61950	COG0784	Response regulator, receiver
NIES4071_61980	COG1166	arginine decarboxylase activity
NIES4071_61990	COG0105	UTP biosynthetic process
NIES4071_62000	COG0861	Integral membrane protein TerC family
NIES4071_62040	COG0625	glutathione transferase activity
NIES4071_62060	COG5554	nitrogen fixation
NIES4071_62070	COG5554	nitrogen fixation
NIES4071_62080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIES4071_62190	COG1879	ABC-type sugar transport system periplasmic component
NIES4071_62200	COG1129	ABC transporter
NIES4071_62210	COG1172	Belongs to the binding-protein-dependent transport system permease family
NIES4071_62220	COG1172	Belongs to the binding-protein-dependent transport system permease family
NIES4071_62280	COG5002	protein histidine kinase activity
NIES4071_62280	COG0784	Response regulator, receiver
NIES4071_62300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES4071_62300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES4071_62330	COG1077	Cell shape determining protein MreB Mrl
NIES4071_62340	COG0629	single-stranded DNA binding
NIES4071_62360	COG0475	glutathione-regulated potassium exporter activity
NIES4071_62370	COG2247	cell wall binding repeat
NIES4071_62370	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES4071_62380	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES4071_62410	COG0142	geranyltranstransferase activity
NIES4071_62460	COG2052	Domain of unknown function (DUF370)
NIES4071_62470	COG0194	GDP metabolic process
NIES4071_62510	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NIES4071_62540	COG0454	-acetyltransferase
NIES4071_62580	COG2890	protein-(glutamine-N5) methyltransferase activity
NIES4071_62590	COG0009	L-threonylcarbamoyladenylate synthase
NIES4071_62600	COG5002	protein histidine kinase activity
NIES4071_62610	COG0454	-acetyltransferase
NIES4071_62630	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIES4071_62640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIES4071_62650	COG0022	dehydrogenase e1 component
NIES4071_62650	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIES4071_62730	COG0523	cobalamin synthesis protein
NIES4071_62780	COG5001	Diguanylate cyclase
NIES4071_62780	COG4251	negative regulation of phosphorylation
NIES4071_62780	COG3706	GGDEF domain
NIES4071_62780	COG2203	Gaf domain
NIES4071_62790	COG4251	negative regulation of phosphorylation
NIES4071_62790	COG2203	Gaf domain
NIES4071_62790	COG5001	Diguanylate cyclase
NIES4071_62790	COG3706	GGDEF domain
NIES4071_62930	COG0387	Pfam Sodium calcium exchanger
NIES4071_62940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_62970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIES4071_62980	COG2146	nitrite reductase [NAD(P)H] activity
NIES4071_63060	COG0840	transmembrane signaling receptor activity
NIES4071_63060	COG2203	Gaf domain
NIES4071_63070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_63120	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NIES4071_63140	COG1160	GTP binding
NIES4071_63200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NIES4071_63210	COG0232	Belongs to the dGTPase family. Type 2 subfamily
NIES4071_63230	COG1122	ATPase activity
NIES4071_63250	COG0310	cobalt ion transport
NIES4071_63260	COG2132	Multicopper oxidase
NIES4071_63290	COG0672	)-iron permease
NIES4071_63410	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIES4071_63460	COG1058	Belongs to the CinA family
NIES4071_63460	COG1546	Belongs to the CinA family
NIES4071_63470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIES4071_63480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NIES4071_63500	COG0297	glycogen (starch) synthase activity
NIES4071_63520	COG0602	queuosine metabolic process
NIES4071_63540	COG0322	excinuclease ABC activity
NIES4071_63580	COG0039	L-malate dehydrogenase activity
NIES4071_63590	COG1011	Hydrolase
NIES4071_63610	COG1252	NADH dehydrogenase
NIES4071_63640	COG1596	polysaccharide export
NIES4071_63640	COG1555	photosystem II stabilization
NIES4071_63650	COG0109	protoheme IX farnesyltransferase activity
NIES4071_63670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NIES4071_63680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NIES4071_63690	COG1845	cytochrome c oxidase, subunit III
NIES4071_63760	COG3240	lipase activity
NIES4071_63910	COG3546	catalase activity
NIES4071_63920	COG1649	PFAM Uncharacterised BCR, COG1649
NIES4071_63950	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
NIES4071_64090	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NIES4071_64100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIES4071_64110	COG0745	RESPONSE REGULATOR receiver
NIES4071_64120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NIES4071_64130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIES4071_64150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NIES4071_64160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES4071_64170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIES4071_64180	COG1943	Transposase
NIES4071_64240	COG3177	Filamentation induced by cAMP protein fic
NIES4071_64290	COG0210	DNA helicase
NIES4071_64460	COG0017	Asparaginyl-tRNA synthetase
NIES4071_64500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NIES4071_64550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NIES4071_64560	COG0724	RNA recognition motif
NIES4071_64580	COG0601	transmembrane transport
NIES4071_64620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NIES4071_64640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NIES4071_64650	COG1268	BioY protein
NIES4071_64680	COG0581	inorganic phosphate transmembrane transporter activity
NIES4071_64730	COG1136	(ABC) transporter
NIES4071_64730	COG0577	efflux transmembrane transporter activity
NIES4071_64740	COG1136	(ABC) transporter
NIES4071_64920	COG3321	synthase
NIES4071_64920	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_64920	COG0604	alcohol dehydrogenase
NIES4071_65090	COG2815	serine threonine protein kinase
NIES4071_65090	COG0515	serine threonine protein kinase
NIES4071_65130	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
NIES4071_65130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIES4071_65190	COG0616	signal peptide processing
NIES4071_65200	COG1304	FMN binding
NIES4071_65210	COG0312	modulator of DNA gyrase
NIES4071_65250	COG1994	Peptidase M50
NIES4071_65250	COG0517	IMP dehydrogenase activity
NIES4071_65270	COG2205	protein histidine kinase activity
NIES4071_65420	COG0784	Response regulator, receiver
NIES4071_65420	COG2205	protein histidine kinase activity
NIES4071_65500	COG5002	protein histidine kinase activity
NIES4071_65700	COG0789	Transcriptional regulator
NIES4071_65720	COG2217	Heavy metal translocating P-type atpase
NIES4071_65740	COG0745	RESPONSE REGULATOR receiver
NIES4071_65750	COG5002	protein histidine kinase activity
NIES4071_65770	COG0583	DNA-binding transcription factor activity
NIES4071_65780	COG0730	response to heat
NIES4071_65830	COG1587	Uroporphyrinogen-III synthase
NIES4071_65840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIES4071_65890	COG3033	Beta-eliminating lyase
NIES4071_65930	COG0723	plastoquinol--plastocyanin reductase activity
NIES4071_65940	COG5002	protein histidine kinase activity
NIES4071_65950	COG1116	anion transmembrane transporter activity
NIES4071_65980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIES4071_66050	COG2205	protein histidine kinase activity
NIES4071_66050	COG0784	Response regulator, receiver
NIES4071_66050	COG2198	Histidine kinase
NIES4071_66090	COG2205	protein histidine kinase activity
NIES4071_66090	COG5002	protein histidine kinase activity
NIES4071_66090	COG0784	Response regulator, receiver
NIES4071_66110	COG0745	RESPONSE REGULATOR receiver
NIES4071_66130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NIES4071_66240	COG0138	bifunctional purine biosynthesis protein purh
NIES4071_66350	COG3536	Protein conserved in bacteria
NIES4071_66360	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NIES4071_66410	COG0745	RESPONSE REGULATOR receiver
NIES4071_66430	COG2197	response regulator
NIES4071_66440	COG2197	response regulator
NIES4071_66450	COG2261	transglycosylase associated protein
NIES4071_66520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NIES4071_66830	COG0726	polysaccharide deacetylase
NIES4071_66870	COG5002	protein histidine kinase activity
NIES4071_66900	COG0025	NhaP-type Na H and K H
NIES4071_66940	COG3794	PFAM blue (type 1) copper domain protein
NIES4071_66960	COG0395	ABC-type sugar transport system, permease component
NIES4071_67020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NIES4071_67030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIES4071_67100	COG1733	regulation of RNA biosynthetic process
NIES4071_67130	COG1696	Membrane protein involved in D-alanine export
NIES4071_67200	COG0424	maF-like protein
NIES4071_67250	COG5634	Uncharacterized conserved protein (DUF2278)
NIES4071_67260	COG2208	phosphoserine phosphatase activity
NIES4071_67270	COG0552	protein localization to endoplasmic reticulum
NIES4071_67310	COG0463	Glycosyl transferase, family 2
NIES4071_67340	COG4968	Prepilin-type N-terminal cleavage methylation domain
NIES4071_67450	COG1215	transferase activity, transferring glycosyl groups
NIES4071_67460	COG0463	Glycosyl transferase, family 2
NIES4071_67470	COG0463	Glycosyl transferase, family 2
NIES4071_67480	COG4969	Belongs to the N-Me-Phe pilin family
NIES4071_67530	COG0438	transferase activity, transferring glycosyl groups
NIES4071_67710	COG0326	Molecular chaperone. Has ATPase activity
NIES4071_67800	COG0542	response to heat
NIES4071_67810	COG3659	wide pore channel activity
NIES4071_67820	COG0346	lactoylglutathione lyase activity
NIES4071_67860	COG0602	queuosine metabolic process
NIES4071_67870	COG0148	phosphopyruvate hydratase activity
NIES4071_67940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NIES4071_67950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIES4071_67950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIES4071_67960	COG0515	serine threonine protein kinase
NIES4071_67960	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_67990	COG0358	DNA primase activity
NIES4071_68010	COG0419	ATPase involved in DNA repair
NIES4071_68050	COG3852	Histidine kinase
NIES4071_68200	COG1196	nuclear chromosome segregation
NIES4071_68320	COG0352	thiamine-phosphate diphosphorylase activity
NIES4071_68360	COG1131	(ABC) transporter
NIES4071_68420	COG3706	GGDEF domain
NIES4071_68420	COG0745	RESPONSE REGULATOR receiver
NIES4071_68440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NIES4071_68470	COG0515	serine threonine protein kinase
NIES4071_68510	COG0515	serine threonine protein kinase
NIES4071_68660	COG0732	type I restriction modification DNA specificity domain
NIES4071_68750	COG0129	dihydroxy-acid dehydratase activity
NIES4071_68790	COG0515	serine threonine protein kinase
NIES4071_68810	COG0538	isocitrate dehydrogenase activity
NIES4071_68830	COG0784	Response regulator, receiver
NIES4071_68880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NIES4071_68900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES4071_68920	COG0675	Transposase, IS605 OrfB family
NIES4071_68950	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES4071_69000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES4071_69010	COG1049	propionate catabolic process, 2-methylcitrate cycle
NIES4071_69140	COG1598	PFAM Uncharacterised protein family UPF0150
NIES4071_69220	COG4106	trans-aconitate 2-methyltransferase activity
NIES4071_69230	COG4106	trans-aconitate 2-methyltransferase activity
NIES4071_69240	COG0583	DNA-binding transcription factor activity
NIES4071_69410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
NIES4071_69460	COG1943	Transposase
NIES4071_69490	COG2885	chlorophyll binding
NIES4071_69580	COG2337	Toxic component of a toxin-antitoxin (TA) module
NIES4071_69590	COG1902	pentaerythritol trinitrate reductase activity
NIES4071_69630	COG5002	protein histidine kinase activity
NIES4071_69630	COG2198	Histidine kinase
NIES4071_69630	COG0784	Response regulator, receiver
NIES4071_69640	COG2823	Periplasmic or secreted lipoprotein
NIES4071_69640	COG1652	LysM domain
NIES4071_69650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NIES4071_69670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NIES4071_69680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NIES4071_69710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIES4071_69710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIES4071_69760	COG0811	peptide transport
NIES4071_69770	COG0848	biopolymer transport protein
NIES4071_69820	COG0408	coproporphyrinogen oxidase activity
NIES4071_69840	COG0489	protein tyrosine kinase activity
NIES4071_69850	COG0772	Belongs to the SEDS family
NIES4071_69880	COG0475	glutathione-regulated potassium exporter activity
NIES4071_69880	COG0589	response to stress
NIES4071_69890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_69900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NIES4071_69930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NIES4071_69950	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NIES4071_69970	COG0137	argininosuccinate synthase activity
NIES4071_69990	COG0586	Pfam SNARE associated Golgi protein
NIES4071_70020	COG0360	Binds together with S18 to 16S ribosomal RNA
NIES4071_70030	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIES4071_70050	COG0799	negative regulation of ribosome biogenesis
NIES4071_70090	COG0335	large ribosomal subunit rRNA binding
NIES4071_70120	COG0250	Participates in transcription elongation, termination and antitermination
NIES4071_70140	COG0081	regulation of translation
NIES4071_70160	COG0222	ribosome binding
NIES4071_70190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NIES4071_70230	COG0857	belongs to the CobB CobQ family
NIES4071_70250	COG2198	Histidine kinase
NIES4071_70250	COG0643	Histidine kinase
NIES4071_70260	COG2203	Gaf domain
NIES4071_70260	COG0840	transmembrane signaling receptor activity
NIES4071_70270	COG0784	Response regulator, receiver
NIES4071_70380	COG0028	Belongs to the TPP enzyme family
NIES4071_70480	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_70480	COG0515	serine threonine protein kinase
NIES4071_70510	COG5002	protein histidine kinase activity
NIES4071_70580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NIES4071_70590	COG1233	COG1233 Phytoene dehydrogenase and related
NIES4071_70610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NIES4071_70660	COG1566	PFAM secretion protein HlyD family protein
NIES4071_70690	COG1742	UPF0060 membrane protein
NIES4071_70720	COG2226	methyltransferase
NIES4071_70780	COG0525	valine-tRNA ligase activity
NIES4071_70790	COG0784	Response regulator, receiver
NIES4071_70790	COG2205	protein histidine kinase activity
NIES4071_70800	COG0784	Response regulator, receiver
NIES4071_70800	COG5002	protein histidine kinase activity
NIES4071_70810	COG0745	RESPONSE REGULATOR receiver
NIES4071_70820	COG3781	membrane
NIES4071_70840	COG3237	CsbD-like
NIES4071_70910	COG1175	transmembrane transport
NIES4071_71070	COG3266	domain, Protein
NIES4071_71070	COG0515	serine threonine protein kinase
NIES4071_71230	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NIES4071_71240	COG0009	L-threonylcarbamoyladenylate synthase
NIES4071_71320	COG2205	protein histidine kinase activity
NIES4071_71320	COG2202	Pas domain
NIES4071_71330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIES4071_71330	COG0519	Catalyzes the synthesis of GMP from XMP
NIES4071_71380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NIES4071_71430	COG2205	protein histidine kinase activity
NIES4071_71440	COG0784	Response regulator, receiver
NIES4071_71450	COG4251	negative regulation of phosphorylation
NIES4071_71480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIES4071_71480	COG0574	Belongs to the PEP-utilizing enzyme family
NIES4071_71500	COG0745	RESPONSE REGULATOR receiver
NIES4071_71560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NIES4071_71580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NIES4071_71700	COG3693	PFAM glycoside hydrolase, family 10
NIES4071_71720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_71730	COG0590	tRNA wobble adenosine to inosine editing
NIES4071_71740	COG2197	response regulator
NIES4071_71750	COG5002	protein histidine kinase activity
NIES4071_71810	COG1472	Belongs to the glycosyl hydrolase 3 family
NIES4071_72010	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIES4071_72060	COG4251	negative regulation of phosphorylation
NIES4071_72060	COG2203	Gaf domain
NIES4071_72060	COG3706	GGDEF domain
NIES4071_72060	COG5001	Diguanylate cyclase
NIES4071_72070	COG0784	Response regulator, receiver
NIES4071_72080	COG4251	negative regulation of phosphorylation
NIES4071_72090	COG1902	pentaerythritol trinitrate reductase activity
NIES4071_72100	COG1902	pentaerythritol trinitrate reductase activity
NIES4071_72110	COG1917	Cupin 2, conserved barrel domain protein
NIES4071_72110	COG4977	sequence-specific DNA binding
NIES4071_72150	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NIES4071_72160	COG1396	sequence-specific DNA binding
NIES4071_72220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_72230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NIES4071_72230	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NIES4071_72250	COG1012	belongs to the aldehyde dehydrogenase family
NIES4071_72260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES4071_72280	COG2205	protein histidine kinase activity
NIES4071_72290	COG0438	transferase activity, transferring glycosyl groups
NIES4071_72330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NIES4071_72400	COG0386	Belongs to the glutathione peroxidase family
NIES4071_72430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NIES4071_72480	COG2205	protein histidine kinase activity
NIES4071_72480	COG0784	Response regulator, receiver
NIES4071_72490	COG0515	serine threonine protein kinase
NIES4071_72490	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_72630	COG2337	Toxic component of a toxin-antitoxin (TA) module
NIES4071_72680	COG2337	Toxic component of a toxin-antitoxin (TA) module
NIES4071_72720	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NIES4071_72740	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NIES4071_72790	COG0438	transferase activity, transferring glycosyl groups
NIES4071_72810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_72820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES4071_72830	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES4071_72840	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES4071_72850	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
NIES4071_72860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NIES4071_72860	COG4451	ribulose bisphosphate carboxylase, small
NIES4071_72890	COG0583	DNA-binding transcription factor activity
NIES4071_72950	COG0667	Aldo Keto reductase
NIES4071_73030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_73040	COG2132	Multicopper oxidase
NIES4071_73070	COG0747	negative chemotaxis
NIES4071_73120	COG0539	negative regulation of cytoplasmic translation
NIES4071_73190	COG0659	secondary active sulfate transmembrane transporter activity
NIES4071_73260	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NIES4071_73290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES4071_73310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES4071_73430	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NIES4071_73490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NIES4071_73520	COG2815	serine threonine protein kinase
NIES4071_73520	COG0515	serine threonine protein kinase
NIES4071_73530	COG0738	Major facilitator superfamily
NIES4071_73580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_73610	COG2319	Wd-40 repeat
NIES4071_73610	COG1672	PFAM Archaeal ATPase
NIES4071_73720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIES4071_73730	COG5398	heme oxygenase
NIES4071_73740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES4071_73780	COG0463	Glycosyl transferase, family 2
NIES4071_73820	COG0726	polysaccharide deacetylase
NIES4071_73830	COG0726	polysaccharide deacetylase
NIES4071_73860	COG0069	glutamate synthase activity
NIES4071_73860	COG0070	glutamate synthase
NIES4071_73860	COG0067	glutamate synthase
NIES4071_73880	COG0662	Cupin 2, conserved barrel domain protein
NIES4071_73880	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NIES4071_73890	COG0316	Belongs to the HesB IscA family
NIES4071_73920	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES4071_73930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NIES4071_73950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NIES4071_73960	COG1605	Chorismate mutase
NIES4071_73960	COG0077	Prephenate dehydratase
NIES4071_73990	COG1530	ribonuclease E activity
NIES4071_74040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NIES4071_74090	COG2770	Histidine kinase
NIES4071_74090	COG3437	response regulator, receiver
NIES4071_74220	COG3842	ATPase activity
NIES4071_74230	COG0745	RESPONSE REGULATOR receiver
NIES4071_74250	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NIES4071_74260	COG0271	Belongs to the BolA IbaG family
NIES4071_74290	COG1404	Belongs to the peptidase S8 family
NIES4071_74290	COG4935	Belongs to the peptidase S8 family
NIES4071_74310	COG0590	tRNA wobble adenosine to inosine editing
NIES4071_74320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIES4071_74330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIES4071_74370	COG0515	serine threonine protein kinase
NIES4071_74370	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_74410	COG1846	Transcriptional regulator
NIES4071_74430	COG0515	serine threonine protein kinase
NIES4071_74440	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_74440	COG0515	serine threonine protein kinase
NIES4071_74490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIES4071_74500	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES4071_74500	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES4071_74540	COG0513	Belongs to the DEAD box helicase family
NIES4071_74600	COG0571	ribonuclease III activity
NIES4071_74810	COG0839	Belongs to the complex I subunit 6 family
NIES4071_74820	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_74840	COG0372	Belongs to the citrate synthase family
NIES4071_74850	COG2062	phosphohistidine phosphatase, SixA
NIES4071_74870	COG1234	tRNA 3'-trailer cleavage
NIES4071_74880	COG2274	protein secretion by the type I secretion system
NIES4071_74980	COG1216	Glycosyl transferase, family 2
NIES4071_74980	COG0463	Glycosyl transferase, family 2
NIES4071_75010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES4071_75020	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NIES4071_75150	COG1216	Glycosyl transferase, family 2
NIES4071_75150	COG0463	Glycosyl transferase, family 2
NIES4071_75170	COG0110	maltose O-acetyltransferase activity
NIES4071_75190	COG3706	GGDEF domain
NIES4071_75190	COG4251	negative regulation of phosphorylation
NIES4071_75190	COG5001	Diguanylate cyclase
NIES4071_75190	COG2203	Gaf domain
NIES4071_75230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NIES4071_75240	COG0628	permease
NIES4071_75260	COG0697	spore germination
NIES4071_75320	COG0306	phosphate transporter
NIES4071_75360	COG1063	alcohol dehydrogenase
NIES4071_75370	COG1819	glycosyl
NIES4071_75380	COG1569	PIN domain
NIES4071_75400	COG3311	Transcriptional regulator
NIES4071_75410	COG3311	Transcriptional regulator
NIES4071_75450	COG1404	Belongs to the peptidase S8 family
NIES4071_75470	COG3573	Dehydrogenase
NIES4071_75520	COG0012	GTP binding
NIES4071_75550	COG1982	Orn Lys Arg decarboxylase major
NIES4071_75560	COG2124	cytochrome p450
NIES4071_75570	COG2815	serine threonine protein kinase
NIES4071_75570	COG0515	serine threonine protein kinase
NIES4071_75590	COG0351	phosphomethylpyrimidine kinase
NIES4071_75590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NIES4071_75590	COG0352	thiamine-phosphate diphosphorylase activity
NIES4071_75710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIES4071_75740	COG1597	lipid kinase activity
NIES4071_75740	COG1803	Methylglyoxal synthase
NIES4071_75750	COG0181	hydroxymethylbilane synthase activity
NIES4071_75930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES4071_75950	COG5002	protein histidine kinase activity
NIES4071_75980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NIES4071_76020	COG4251	negative regulation of phosphorylation
NIES4071_76210	COG1309	transcriptional regulator
NIES4071_76240	COG1595	DNA-templated transcription, initiation
NIES4071_76250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NIES4071_76300	COG3659	wide pore channel activity
NIES4071_76330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIES4071_76380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NIES4071_76390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIES4071_76390	COG0512	Glutamine amidotransferase of anthranilate synthase
NIES4071_76440	COG5002	protein histidine kinase activity
NIES4071_76440	COG2198	Histidine kinase
NIES4071_76440	COG0784	Response regulator, receiver
NIES4071_76470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_76550	COG4294	response to UV
NIES4071_76600	COG2319	Wd-40 repeat
NIES4071_76600	COG1672	PFAM Archaeal ATPase
NIES4071_76840	COG2274	protein secretion by the type I secretion system
NIES4071_76900	COG2161	toxin-antitoxin pair type II binding
NIES4071_76910	COG4115	mRNA cleavage
NIES4071_77000	COG2319	Wd-40 repeat
NIES4071_77000	COG1672	PFAM Archaeal ATPase
NIES4071_77020	COG2205	protein histidine kinase activity
NIES4071_77020	COG0784	Response regulator, receiver
NIES4071_77030	COG2205	protein histidine kinase activity
NIES4071_77030	COG0784	Response regulator, receiver
NIES4071_77030	COG5002	protein histidine kinase activity
NIES4071_77050	COG2172	sigma factor antagonist activity
NIES4071_77060	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES4071_77070	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES4071_77090	COG2815	serine threonine protein kinase
NIES4071_77090	COG0515	serine threonine protein kinase
NIES4071_77110	COG0432	Pfam Uncharacterised protein family UPF0047
NIES4071_77190	COG2202	Pas domain
NIES4071_77190	COG2205	protein histidine kinase activity
NIES4071_77220	COG0735	belongs to the Fur family
NIES4071_77230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES4071_77250	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIES4071_77300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIES4071_77300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIES4071_77310	COG0561	phosphatase activity
NIES4071_77330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_77340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_77350	COG0515	serine threonine protein kinase
NIES4071_77360	COG0583	DNA-binding transcription factor activity
NIES4071_77380	COG3118	belongs to the thioredoxin family
NIES4071_77390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES4071_77410	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_77430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIES4071_77460	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NIES4071_77520	COG0058	SHG alpha-glucan phosphorylase activity
NIES4071_77540	COG0784	Response regulator, receiver
NIES4071_77540	COG2198	Histidine kinase
NIES4071_77540	COG5002	protein histidine kinase activity
NIES4071_77570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES4071_77620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIES4071_77630	COG0463	Glycosyl transferase, family 2
NIES4071_77700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NIES4071_77700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NIES4071_77780	COG3659	wide pore channel activity
NIES4071_77790	COG3659	wide pore channel activity
NIES4071_77800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_77810	COG0704	Plays a role in the regulation of phosphate uptake
NIES4071_77820	COG5002	protein histidine kinase activity
NIES4071_77830	COG0745	RESPONSE REGULATOR receiver
NIES4071_77900	COG0800	Aldolase
NIES4071_77920	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NIES4071_77950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIES4071_77970	COG0460	homoserine dehydrogenase
NIES4071_77990	COG0572	uridine kinase
NIES4071_78000	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NIES4071_78010	COG2202	Pas domain
NIES4071_78010	COG2205	protein histidine kinase activity
NIES4071_78050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_78080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NIES4071_78090	COG0859	PFAM glycosyl transferase family 9
NIES4071_78120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES4071_78130	COG0248	Ppx GppA phosphatase
NIES4071_78170	COG0697	spore germination
NIES4071_78220	COG0438	transferase activity, transferring glycosyl groups
NIES4071_78230	COG0612	Peptidase, M16
NIES4071_78240	COG0612	Peptidase, M16
NIES4071_78250	COG1309	transcriptional regulator
NIES4071_78290	COG0006	proline dipeptidase activity
NIES4071_78320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NIES4071_78340	COG1837	Belongs to the UPF0109 family
NIES4071_78360	COG1702	phosphate starvation-inducible protein PhoH
NIES4071_78370	COG5001	Diguanylate cyclase
NIES4071_78370	COG3706	GGDEF domain
NIES4071_78370	COG4251	negative regulation of phosphorylation
NIES4071_78370	COG2203	Gaf domain
NIES4071_78390	COG4991	sh3 domain protein
NIES4071_78390	COG0515	serine threonine protein kinase
NIES4071_78390	COG3064	Membrane
NIES4071_78400	COG0515	serine threonine protein kinase
NIES4071_78400	COG3064	Membrane
NIES4071_78400	COG4991	sh3 domain protein
NIES4071_78450	COG2205	protein histidine kinase activity
NIES4071_78520	COG1104	cysteine desulfurase activity
NIES4071_78540	COG4191	Histidine kinase
NIES4071_78540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_78660	COG1598	PFAM Uncharacterised protein family UPF0150
NIES4071_78680	COG0511	ligase activity, forming carbon-carbon bonds
NIES4071_78690	COG0640	Transcriptional regulator
NIES4071_78730	COG1132	(ABC) transporter
NIES4071_78820	COG2124	cytochrome p450
NIES4071_78920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES4071_78980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES4071_78980	COG2022	thiamine diphosphate biosynthetic process
NIES4071_79020	COG2124	cytochrome p450
NIES4071_79020	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIES4071_79030	COG1309	transcriptional regulator
NIES4071_79060	COG0827	DNA restriction-modification system
NIES4071_79070	COG0827	DNA restriction-modification system
NIES4071_79210	COG0803	Belongs to the bacterial solute-binding protein 9 family
NIES4071_79220	COG3659	wide pore channel activity
NIES4071_79300	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_79460	COG2048	Heterodisulfide reductase, subunit B
NIES4071_79470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIES4071_79480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIES4071_79490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NIES4071_79610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIES4071_79620	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_79620	COG0515	serine threonine protein kinase
NIES4071_79630	COG0275	rRNA processing
NIES4071_79650	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES4071_79710	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NIES4071_79780	COG1169	isochorismate synthase
NIES4071_79790	COG1575	Belongs to the MenA family. Type 1 subfamily
NIES4071_79800	COG4948	Mandelate Racemase Muconate Lactonizing
NIES4071_79810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NIES4071_79820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIES4071_79830	COG0416	fatty acid biosynthetic process
NIES4071_79840	COG2027	D-alanyl-D-alanine carboxypeptidase
NIES4071_79870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIES4071_79930	COG5001	Diguanylate cyclase
NIES4071_79940	COG0745	RESPONSE REGULATOR receiver
NIES4071_79950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_79950	COG2205	protein histidine kinase activity
NIES4071_79990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NIES4071_80020	COG3118	belongs to the thioredoxin family
NIES4071_80030	COG0516	GMP reductase activity
NIES4071_80040	COG1193	negative regulation of DNA recombination
NIES4071_80140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NIES4071_80170	COG0443	Heat shock 70 kDa protein
NIES4071_80180	COG0484	heat shock protein binding
NIES4071_80240	COG1316	TRANSCRIPTIONal
NIES4071_80260	COG0628	permease
NIES4071_80300	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NIES4071_80310	COG0612	Peptidase, M16
NIES4071_80320	COG0612	Peptidase, M16
NIES4071_80330	COG3773	Cell wall hydrolase
NIES4071_80330	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_80420	COG2205	protein histidine kinase activity
NIES4071_80430	COG0494	nUDIX hydrolase
NIES4071_80450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES4071_80460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NIES4071_80470	COG0783	Belongs to the Dps family
NIES4071_80510	COG3639	organic phosphonate transmembrane transporter activity
NIES4071_80520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NIES4071_80540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_80540	COG2198	Histidine kinase
NIES4071_80540	COG0784	Response regulator, receiver
NIES4071_80540	COG2205	protein histidine kinase activity
NIES4071_80550	COG0419	ATPase involved in DNA repair
NIES4071_80580	COG0251	oxidation-reduction process
NIES4071_80600	COG1051	belongs to the nudix hydrolase family
NIES4071_80610	COG1640	4-alpha-glucanotransferase
NIES4071_80630	COG1187	pseudouridine synthase activity
NIES4071_80660	COG0575	Belongs to the CDS family
NIES4071_80680	COG3266	domain, Protein
NIES4071_80680	COG0515	serine threonine protein kinase
NIES4071_80690	COG3064	Membrane
NIES4071_80690	COG0515	serine threonine protein kinase
NIES4071_80690	COG4991	sh3 domain protein
NIES4071_80810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NIES4071_80830	COG4242	Belongs to the peptidase S51 family
NIES4071_80840	COG0336	Belongs to the RNA methyltransferase TrmD family
NIES4071_80850	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NIES4071_80880	COG0747	negative chemotaxis
NIES4071_80900	COG0747	negative chemotaxis
NIES4071_80910	COG1691	(AIR) carboxylase
NIES4071_80930	COG0165	Argininosuccinate lyase
NIES4071_80970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NIES4071_80980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES4071_80980	COG0426	domain, Protein
NIES4071_80990	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES4071_80990	COG0426	domain, Protein
NIES4071_81100	COG1160	GTP binding
NIES4071_81240	COG2203	Gaf domain
NIES4071_81240	COG5001	Diguanylate cyclase
NIES4071_81240	COG3706	GGDEF domain
NIES4071_81240	COG4251	negative regulation of phosphorylation
NIES4071_81310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NIES4071_81340	COG2205	protein histidine kinase activity
NIES4071_81410	COG1785	Belongs to the alkaline phosphatase family
NIES4071_81430	COG0516	GMP reductase activity
NIES4071_81430	COG0517	IMP dehydrogenase activity
NIES4071_81490	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NIES4071_81530	COG0515	serine threonine protein kinase
NIES4071_81530	COG3266	domain, Protein
NIES4071_81550	COG0515	serine threonine protein kinase
NIES4071_81590	COG0779	Required for maturation of 30S ribosomal subunits
NIES4071_81600	COG0195	Participates in both transcription termination and antitermination
NIES4071_81630	COG3266	domain, Protein
NIES4071_81630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NIES4071_81690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIES4071_81700	COG0438	transferase activity, transferring glycosyl groups
NIES4071_81710	COG0463	Glycosyl transferase, family 2
NIES4071_81710	COG1216	Glycosyl transferase, family 2
NIES4071_81750	COG1381	Involved in DNA repair and RecF pathway recombination
NIES4071_81770	COG0438	transferase activity, transferring glycosyl groups
NIES4071_81780	COG0542	response to heat
NIES4071_81800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NIES4071_81840	COG1027	Aspartate ammonia-lyase
NIES4071_81850	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIES4071_81870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NIES4071_81900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIES4071_81910	COG0583	DNA-binding transcription factor activity
NIES4071_81970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES4071_81980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES4071_81990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES4071_81990	COG1116	anion transmembrane transporter activity
NIES4071_82000	COG1116	anion transmembrane transporter activity
NIES4071_82010	COG2223	nitrite transmembrane transporter activity
NIES4071_82020	COG0243	molybdopterin cofactor binding
NIES4071_82110	COG0693	protein deglycase activity
NIES4071_82190	COG0745	RESPONSE REGULATOR receiver
NIES4071_82200	COG1215	transferase activity, transferring glycosyl groups
NIES4071_82220	COG0793	Belongs to the peptidase S41A family
NIES4071_82300	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIES4071_82300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIES4071_82320	COG1413	lyase activity
NIES4071_82330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIES4071_82420	COG2261	transglycosylase associated protein
NIES4071_82430	COG3237	CsbD-like
NIES4071_82440	COG2197	response regulator
NIES4071_82460	COG0457	Tetratricopeptide repeat
NIES4071_82460	COG0463	Glycosyl transferase, family 2
NIES4071_82470	COG0436	Aminotransferase
NIES4071_82500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES4071_82500	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NIES4071_82740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NIES4071_82780	COG0318	PFAM AMP-dependent synthetase and ligase
NIES4071_82840	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NIES4071_82860	COG2319	Wd-40 repeat
NIES4071_82860	COG3903	Transcriptional regulator
NIES4071_82970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIES4071_83000	COG2205	protein histidine kinase activity
NIES4071_83000	COG0784	Response regulator, receiver
NIES4071_83010	COG0402	S-adenosylhomocysteine deaminase activity
NIES4071_83070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NIES4071_83090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIES4071_83100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIES4071_83210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIES4071_83290	COG0574	Belongs to the PEP-utilizing enzyme family
NIES4071_83290	COG3848	Pyruvate phosphate dikinase
NIES4071_83330	COG1132	(ABC) transporter
NIES4071_83340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIES4071_83420	COG1203	CRISPR-associated helicase, Cas3
NIES4071_83440	COG1857	crispr-associated protein
NIES4071_83460	COG1468	defense response to virus
NIES4071_83460	COG1518	maintenance of DNA repeat elements
NIES4071_83470	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NIES4071_83630	COG0515	serine threonine protein kinase
NIES4071_83630	COG2815	serine threonine protein kinase
NIES4071_83670	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_83740	COG1834	amidinotransferase
NIES4071_83810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NIES4071_83930	COG3788	relative of glutathione S-transferase, MAPEG superfamily
NIES4071_84040	COG0297	glycogen (starch) synthase activity
NIES4071_84080	COG1215	transferase activity, transferring glycosyl groups
NIES4071_84090	COG1045	serine acetyltransferase
NIES4071_84100	COG3206	protein involved in exopolysaccharide biosynthesis
NIES4071_84100	COG0489	protein tyrosine kinase activity
NIES4071_84110	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NIES4071_84160	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES4071_84200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NIES4071_84200	COG1215	transferase activity, transferring glycosyl groups
NIES4071_84240	COG1940	carbohydrate kinase activity
NIES4071_84260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIES4071_84270	COG0492	ferredoxin-NADP+ reductase activity
NIES4071_84360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_84370	COG4968	Prepilin-type N-terminal cleavage methylation domain
NIES4071_84400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NIES4071_84490	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_84490	COG0515	serine threonine protein kinase
NIES4071_84510	COG5002	protein histidine kinase activity
NIES4071_84520	COG1187	pseudouridine synthase activity
NIES4071_84550	COG0484	heat shock protein binding
NIES4071_84600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIES4071_84610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NIES4071_84630	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NIES4071_84670	COG1253	flavin adenine dinucleotide binding
NIES4071_84680	COG0673	inositol 2-dehydrogenase activity
NIES4071_84690	COG0586	Pfam SNARE associated Golgi protein
NIES4071_84830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NIES4071_84860	COG0351	phosphomethylpyrimidine kinase
NIES4071_84870	COG3852	Histidine kinase
NIES4071_84890	COG1404	Belongs to the peptidase S8 family
NIES4071_84930	COG2949	membrane
NIES4071_84980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIES4071_85020	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_85020	COG0515	serine threonine protein kinase
NIES4071_85040	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NIES4071_85090	COG3263	regulation of cellular component size
NIES4071_85260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NIES4071_85330	COG1252	NADH dehydrogenase
NIES4071_85370	COG0784	Response regulator, receiver
NIES4071_85370	COG4191	Histidine kinase
NIES4071_85410	COG1515	deoxyribonuclease V activity
NIES4071_85450	COG0515	serine threonine protein kinase
NIES4071_85450	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES4071_85460	COG1803	Methylglyoxal synthase
NIES4071_85540	COG5002	protein histidine kinase activity
NIES4071_85550	COG2197	response regulator
NIES4071_85580	COG3240	lipase activity
NIES4071_85700	COG2124	cytochrome p450
NIES4071_85930	COG0464	growth
NIES4071_85950	COG0515	serine threonine protein kinase
NIES4071_85970	COG2988	succinylglutamate desuccinylase activity
NIES4071_86020	COG2831	hemolysin activation secretion protein
NIES4071_86050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_86060	COG0385	Bile acid
NIES4071_86070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIES4071_86110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NIES4071_86170	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NIES4071_86190	COG2223	nitrite transmembrane transporter activity
NIES4071_86270	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES4071_86270	COG3409	Peptidoglycan-binding domain 1 protein
NIES4071_86360	COG2319	Wd-40 repeat
NIES4071_86360	COG1672	PFAM Archaeal ATPase
NIES4071_86370	COG3903	Transcriptional regulator
NIES4071_86370	COG2319	Wd-40 repeat
NIES4071_86420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NIES4071_86430	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NIES4071_86440	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NIES4071_86450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NIES4071_86830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_86890	COG0515	serine threonine protein kinase
NIES4071_86890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIES4071_86910	COG0154	amidase activity
NIES4071_87010	COG0515	serine threonine protein kinase
NIES4071_87010	COG3266	domain, Protein
NIES4071_87020	COG2205	protein histidine kinase activity
NIES4071_87020	COG0784	Response regulator, receiver
NIES4071_87060	COG3659	wide pore channel activity
NIES4071_87070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_87080	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_87090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES4071_87100	COG1773	rubredoxin
NIES4071_87190	COG1191	sigma factor activity
NIES4071_87270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NIES4071_87280	COG0189	ligase activity
NIES4071_87290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES4071_87330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NIES4071_87350	COG4680	protein conserved in bacteria
NIES4071_87500	COG4191	Histidine kinase
NIES4071_87590	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_87600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES4071_87640	COG2197	response regulator
NIES4071_87660	COG4585	Histidine kinase
NIES4071_87710	COG1192	Involved in chromosome partitioning
NIES4071_87830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NIES4071_87860	COG2205	protein histidine kinase activity
NIES4071_87860	COG3437	response regulator, receiver
NIES4071_87860	COG3850	Histidine kinase
NIES4071_87860	COG4999	Histidine kinase
NIES4071_87940	COG1132	(ABC) transporter
NIES4071_87980	COG1216	Glycosyl transferase, family 2
NIES4071_88000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIES4071_88010	COG1442	glycosyl transferase family 8
NIES4071_88040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_88050	COG1554	hydrolase, family 65, central catalytic
NIES4071_88060	COG0438	transferase activity, transferring glycosyl groups
NIES4071_88080	COG0625	glutathione transferase activity
NIES4071_88100	COG0583	DNA-binding transcription factor activity
NIES4071_88130	COG0328	RNA-DNA hybrid ribonuclease activity
NIES4071_88180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NIES4071_88210	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES4071_88230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NIES4071_88260	COG1126	abc transporter atp-binding protein
NIES4071_88340	COG3118	belongs to the thioredoxin family
NIES4071_88360	COG2264	protein methyltransferase activity
NIES4071_88370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIES4071_88440	COG1850	ribulose-bisphosphate carboxylase activity
NIES4071_88460	COG4451	ribulose bisphosphate carboxylase, small
NIES4071_88550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES4071_88580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NIES4071_88590	COG5001	Diguanylate cyclase
NIES4071_88590	COG1716	ATPase activity
NIES4071_88750	COG0542	response to heat
NIES4071_88770	COG0659	secondary active sulfate transmembrane transporter activity
NIES4071_88820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NIES4071_88850	COG3540	Alkaline phosphatase
NIES4071_88880	COG0288	reversible hydration of carbon dioxide
NIES4071_88900	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NIES4071_88910	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NIES4071_88920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIES4071_88930	COG2226	methyltransferase
NIES4071_88960	COG1793	dna ligase
NIES4071_89000	COG0359	binds to the 23S rRNA
NIES4071_89040	COG1372	Participates in initiation and elongation during chromosome replication
NIES4071_89040	COG0305	Participates in initiation and elongation during chromosome replication
NIES4071_89090	COG1573	uracil-dna glycosylase
NIES4071_89130	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
NIES4071_89170	COG0003	Pfam Anion-transporting ATPase
NIES4071_89190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NIES4071_89190	COG4191	Histidine kinase
NIES4071_89200	COG0592	DNA-directed DNA polymerase activity
NIES4071_89210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NIES4071_89220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES4071_89240	COG0242	peptide deformylase activity
NIES4071_89260	COG2217	Heavy metal translocating P-type atpase
NIES4071_89320	COG3093	addiction module antidote protein HigA
NIES4071_89370	COG2376	Dihydroxyacetone kinase
NIES4071_89380	COG1461	Dihydroxyacetone kinase
NIES4071_89460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NIES4071_89510	COG1309	transcriptional regulator
NIES4071_89520	COG1104	cysteine desulfurase activity
NIES4071_89530	COG0655	NAD(P)H dehydrogenase (quinone) activity
NIES4071_89670	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NIES4071_89680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NIES4071_89720	COG3842	ATPase activity
NIES4071_89750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NIES4071_89780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NIES4071_89790	COG2340	Cysteine-rich secretory protein family
NIES4071_89810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NIES4071_89980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIES4071_90060	COG4636	protein conserved in cyanobacteria
NIES4071_90250	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIES4071_90470	COG1216	Glycosyl transferase, family 2
NIES4071_90480	COG2244	polysaccharide biosynthetic process
NIES4071_90500	COG0438	transferase activity, transferring glycosyl groups
NIES4071_90560	COG5002	protein histidine kinase activity
NIES4071_90630	COG0745	RESPONSE REGULATOR receiver
NIES4071_90670	COG2319	Wd-40 repeat
NIES4071_90670	COG3903	Transcriptional regulator
NIES4071_90760	COG1126	abc transporter atp-binding protein
NIES4071_90770	COG0765	amino acid transport
NIES4071_90790	COG0640	Transcriptional regulator
NIES4071_90900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES4071_90910	COG0573	inorganic phosphate transmembrane transporter activity
NIES4071_90920	COG0581	inorganic phosphate transmembrane transporter activity
NIES4071_90960	COG1785	Belongs to the alkaline phosphatase family
NIES4071_90980	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NIES4071_90990	COG0584	glycerophosphoryl diester phosphodiesterase
NIES4071_91040	COG0596	Alpha beta hydrolase
NIES4071_91070	COG2884	Cell division ATP-binding protein ftsE
NIES4071_91090	COG2197	response regulator
NIES4071_91100	COG2204	response regulator
NIES4071_91130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NIES4071_91140	COG0546	phosphoglycolate phosphatase activity
NIES4071_91160	COG3631	Ketosteroid isomerase-related protein
NIES4071_91170	COG1136	(ABC) transporter
NIES4071_91180	COG0577	efflux transmembrane transporter activity
NIES4071_91180	COG1136	(ABC) transporter
NIES4071_91190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES4071_91450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIES4071_91460	COG0681	Belongs to the peptidase S26 family
NIES4071_91470	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
NIES4071_91510	COG0131	Imidazoleglycerol-phosphate dehydratase
NIES4071_91520	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NIES4071_91540	COG4372	Transposase
NIES4071_91580	COG1185	polyribonucleotide nucleotidyltransferase activity
NIES4071_91590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_91590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES4071_91610	COG4279	zinc finger
NIES4071_91630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NIES4071_91650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NIES4071_91650	COG0140	phosphoribosyl-ATP diphosphatase activity
NIES4071_91800	COG4680	protein conserved in bacteria
NIES4071_91810	COG5499	transcription regulator containing HTH domain
NIES4071_91900	COG0438	transferase activity, transferring glycosyl groups
NIES4071_91940	COG1216	Glycosyl transferase, family 2
NIES4071_91960	COG1132	(ABC) transporter
NIES4071_91980	COG0489	protein tyrosine kinase activity
NIES4071_91990	COG0438	transferase activity, transferring glycosyl groups
NIES4071_92040	COG1216	Glycosyl transferase, family 2
NIES4071_92060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIES4071_92070	COG0579	oxidoreductase
NIES4071_92080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES4071_92110	COG4245	von Willebrand factor, type A
NIES4071_92120	COG0784	Response regulator, receiver
NIES4071_92200	COG4451	ribulose bisphosphate carboxylase, small
NIES4071_92200	COG0464	growth
NIES4071_92390	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES4071_92400	COG0432	Pfam Uncharacterised protein family UPF0047
NIES4071_92420	COG0702	epimerase
NIES4071_92430	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NIES4071_92480	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES4071_92520	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NIES4071_92530	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NIES4071_92540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NIES4071_92580	COG0706	membrane insertase activity
NIES4071_92620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_92670	COG3706	GGDEF domain
NIES4071_92670	COG0745	RESPONSE REGULATOR receiver
NIES4071_92720	COG1830	Aldolase
NIES4071_92740	COG0675	Transposase, IS605 OrfB family
NIES4071_92910	COG1012	belongs to the aldehyde dehydrogenase family
NIES4071_92990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIES4071_93000	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES4071_93040	COG0670	Belongs to the BI1 family
NIES4071_93070	COG0066	3-isopropylmalate dehydratase activity
NIES4071_93080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NIES4071_93090	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NIES4071_93120	COG0589	response to stress
NIES4071_93120	COG0475	glutathione-regulated potassium exporter activity
NIES4071_93180	COG0010	Belongs to the arginase family
NIES4071_93220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NIES4071_93230	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIES4071_93270	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NIES4071_93290	COG1032	radical SAM domain protein
NIES4071_93310	COG1215	transferase activity, transferring glycosyl groups
NIES4071_93360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NIES4071_93370	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NIES4071_93390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NIES4071_93420	COG1543	Belongs to the glycosyl hydrolase 57 family
NIES4071_93450	COG0233	cytoplasmic translational termination
NIES4071_93460	COG0492	ferredoxin-NADP+ reductase activity
NIES4071_93510	COG0515	serine threonine protein kinase
NIES4071_93530	COG0439	Biotin carboxylase
NIES4071_93570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NIES4071_93590	COG0037	tRNA processing
NIES4071_93600	COG1012	belongs to the aldehyde dehydrogenase family
NIES4071_93630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NIES4071_93640	COG0784	Response regulator, receiver
NIES4071_93640	COG2205	protein histidine kinase activity
NIES4071_93670	COG1285	pathogenesis
NIES4071_93680	COG0612	Peptidase, M16
NIES4071_93820	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NIES4071_93840	COG3239	Fatty acid desaturase
NIES4071_93850	COG3239	Fatty acid desaturase
NIES4071_93860	COG3239	Fatty acid desaturase
NIES4071_93880	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NIES4071_93910	COG2201	protein-glutamate methylesterase activity
NIES4071_93920	COG0840	transmembrane signaling receptor activity
NIES4071_93930	COG0835	chemotaxis
NIES4071_93940	COG0643	Histidine kinase
NIES4071_93940	COG2198	Histidine kinase
NIES4071_93950	COG0745	RESPONSE REGULATOR receiver
NIES4071_93990	COG5002	protein histidine kinase activity
NIES4071_94000	COG0151	Belongs to the GarS family
NIES4071_94010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES4071_94080	COG0432	Pfam Uncharacterised protein family UPF0047
NIES4071_94180	COG0515	serine threonine protein kinase
NIES4071_94180	COG2815	serine threonine protein kinase
NIES4071_94190	COG2815	serine threonine protein kinase
NIES4071_94190	COG0515	serine threonine protein kinase
NIES4071_94230	COG2197	response regulator
NIES4071_94290	COG3265	gluconokinase activity
NIES4071_94400	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NIES4071_94410	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIES4071_94410	COG0515	serine threonine protein kinase
NIES4071_94420	COG0121	glutamine amidotransferase
NIES4071_94490	COG1598	PFAM Uncharacterised protein family UPF0150
NIES4071_94570	COG1429	ligase activity, forming nitrogen-metal bonds
NIES4071_94670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_94690	COG1051	belongs to the nudix hydrolase family
NIES4071_94710	COG0589	response to stress
NIES4071_94720	COG0784	Response regulator, receiver
NIES4071_94750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIES4071_94760	COG4956	integral membrane protein (PIN domain superfamily)
NIES4071_95000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIES4071_95150	COG1022	Amp-dependent synthetase and ligase
NIES4071_95160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NIES4071_95250	COG4221	oxidoreductase activity
NIES4071_95270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIES4071_95300	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NIES4071_95330	COG0745	RESPONSE REGULATOR receiver
NIES4071_95360	COG3659	wide pore channel activity
NIES4071_95470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIES4071_95490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES4071_95510	COG1489	DNA binding
NIES4071_95570	COG1649	PFAM Uncharacterised BCR, COG1649
NIES4071_95600	COG0270	DNA (cytosine-5-)-methyltransferase activity
NIES4071_95620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIES4071_95630	COG0406	alpha-ribazole phosphatase activity
NIES4071_95670	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES4071_95700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NIES4071_95710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIES4071_95790	COG0395	ABC-type sugar transport system, permease component
NIES4071_95800	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES4071_95810	COG5322	oxidoreductase activity
NIES4071_95820	COG0825	malonyl-CoA metabolic process
NIES4071_95830	COG0300	oxidoreductase activity
NIES4071_95840	COG0302	gtp cyclohydrolase
NIES4071_95850	COG0135	phosphoribosylanthranilate isomerase activity
NIES4071_95880	COG0517	IMP dehydrogenase activity
NIES4071_95880	COG1994	Peptidase M50
NIES4071_95900	COG1216	Glycosyl transferase, family 2
NIES4071_95910	COG0095	Lipoate-protein ligase
NIES4071_95930	COG2124	cytochrome p450
NIES4071_95940	COG0606	chelatase, subunit chli
NIES4071_95950	COG0537	adenosine 5'-monophosphoramidase activity
NIES4071_95990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NIES4071_96000	COG1846	Transcriptional regulator
NIES4071_96040	COG2010	Cytochrome c
NIES4071_96060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NIES4071_96070	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NIES4071_96130	COG2816	NAD+ diphosphatase activity
NIES4071_96200	COG0018	arginyl-trna synthetase
NIES4071_96240	COG0157	Belongs to the NadC ModD family
NIES4071_96270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NIES4071_96280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIES4071_96380	COG2274	protein secretion by the type I secretion system
NIES4071_96430	COG2226	methyltransferase
NIES4071_96490	COG0714	Associated with various cellular activities
NIES4071_96580	COG2226	methyltransferase
NIES4071_96660	COG0675	Transposase, IS605 OrfB family
NIES4071_96740	COG0604	alcohol dehydrogenase
NIES4071_96780	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NIES4071_96790	COG1028	Short-chain dehydrogenase reductase Sdr
NIES4071_96800	COG1309	transcriptional regulator
NIES4071_96810	COG2124	cytochrome p450
NIES4071_96850	COG2207	Transcriptional regulator
NIES4071_96920	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NIES4071_96930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIES4071_96960	COG1192	Involved in chromosome partitioning
NIES4071_96980	COG3657	addiction module killer protein
NIES4071_97030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES4071_97060	COG1442	glycosyl transferase family 8
NIES4071_97070	COG1442	glycosyl transferase family 8
NIES4071_97090	COG1215	transferase activity, transferring glycosyl groups
NIES4071_97100	COG0438	transferase activity, transferring glycosyl groups
NIES4071_97120	COG3659	wide pore channel activity
NIES4071_97160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIES4071_97200	COG3394	polysaccharide catabolic process
NIES4071_97270	COG0631	protein serine/threonine phosphatase activity
NIES4071_97280	COG0515	serine threonine protein kinase
NIES4071_97360	COG5002	protein histidine kinase activity
NIES4071_97360	COG3850	Histidine kinase
NIES4071_97370	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NIES4071_97400	COG2198	Histidine kinase
NIES4071_97400	COG0643	Histidine kinase
NIES4071_97410	COG2203	Gaf domain
NIES4071_97410	COG0840	transmembrane signaling receptor activity
NIES4071_97440	COG0784	Response regulator, receiver
NIES4071_97460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NIES4071_97490	COG2385	sporulation resulting in formation of a cellular spore
NIES4071_97540	COG0489	protein tyrosine kinase activity
NIES4071_97570	COG2081	HI0933 family
NIES4071_97620	COG0793	Belongs to the peptidase S41A family
NIES4071_97630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_97660	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES4071_97670	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES4071_97690	COG2267	carboxylic ester hydrolase activity
NIES4071_97700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NIES4071_97720	COG1192	Involved in chromosome partitioning
NIES4071_97730	COG2124	cytochrome p450
NIES4071_97750	COG1132	(ABC) transporter
NIES4071_97780	COG0488	(ABC) transporter
NIES4071_97810	COG5001	Diguanylate cyclase
NIES4071_97810	COG4251	negative regulation of phosphorylation
NIES4071_97810	COG3706	GGDEF domain
NIES4071_97810	COG2203	Gaf domain
NIES4071_97820	COG5002	protein histidine kinase activity
NIES4071_97880	COG1959	2 iron, 2 sulfur cluster binding
NIES4071_97890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_97920	COG4208	sulfate ABC transporter
NIES4071_97930	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NIES4071_97940	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NIES4071_97970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIES4071_97980	COG0730	response to heat
NIES4071_98000	COG0583	DNA-binding transcription factor activity
NIES4071_98110	COG0515	serine threonine protein kinase
NIES4071_98110	COG3266	domain, Protein
NIES4071_98170	COG2208	phosphoserine phosphatase activity
NIES4071_98180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NIES4071_98200	COG2912	Transglutaminase-like superfamily
NIES4071_98370	COG0484	heat shock protein binding
NIES4071_98380	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NIES4071_98390	COG3903	Transcriptional regulator
NIES4071_98390	COG2319	Wd-40 repeat
NIES4071_98470	COG0475	glutathione-regulated potassium exporter activity
NIES4071_98480	COG0577	efflux transmembrane transporter activity
NIES4071_98480	COG1136	(ABC) transporter
NIES4071_98510	COG1442	glycosyl transferase family 8
NIES4071_98510	COG1216	Glycosyl transferase, family 2
NIES4071_98520	COG0463	Glycosyl transferase, family 2
NIES4071_98520	COG1216	Glycosyl transferase, family 2
NIES4071_98550	COG1132	(ABC) transporter
NIES4071_98600	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIES4071_98630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES4071_98680	COG1509	lysine 2,3-aminomutase activity
NIES4071_98690	COG1181	Belongs to the D-alanine--D-alanine ligase family
NIES4071_98700	COG0728	peptidoglycan biosynthetic process
NIES4071_98720	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NIES4071_98730	COG2720	vancomycin resistance protein
NIES4071_98740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NIES4071_98750	COG0395	ABC-type sugar transport system, permease component
NIES4071_98760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES4071_98790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES4071_98810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NIES4071_98840	COG2831	hemolysin activation secretion protein
NIES4071_98910	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES4071_98930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NIES4071_98960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIES4071_98980	COG0616	signal peptide processing
NIES4071_99030	COG0469	pyruvate kinase activity
NIES4071_99040	COG0784	Response regulator, receiver
NIES4071_99040	COG5002	protein histidine kinase activity
NIES4071_99040	COG2198	Histidine kinase
NIES4071_99050	COG4251	negative regulation of phosphorylation
NIES4071_99060	COG0438	transferase activity, transferring glycosyl groups
NIES4071_99140	COG0542	response to heat
NIES4071_99160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NIES4071_99160	COG0515	serine threonine protein kinase
NIES4071_99230	COG4680	protein conserved in bacteria
NIES4071_99260	COG4249	Peptidase C14 caspase catalytic subunit p20
NIES4071_99260	COG2319	Wd-40 repeat
NIES4071_99320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES4071_99330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES4071_99420	COG1716	ATPase activity
NIES4071_99430	COG4636	protein conserved in cyanobacteria
NIES4071_99440	COG2226	methyltransferase
NIES4071_99480	COG1372	Participates in initiation and elongation during chromosome replication
NIES4071_99480	COG1372	Participates in initiation and elongation during chromosome replication
NIES4071_99480	COG0305	Participates in initiation and elongation during chromosome replication
NIES4071_99480	COG0305	Participates in initiation and elongation during chromosome replication
NIES4071_99580	COG5002	protein histidine kinase activity
NIES4071_99590	COG0745	RESPONSE REGULATOR receiver
NIES4071_99630	COG0431	NADPH-dependent FMN reductase
NIES4071_99660	COG0784	Response regulator, receiver
NIES4071_99670	COG2203	Gaf domain
NIES4071_99670	COG0840	transmembrane signaling receptor activity
NIES4071_99680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES4071_99750	COG1022	Amp-dependent synthetase and ligase
NIES4071_99760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NIES4071_99840	COG0629	single-stranded DNA binding
NIES4071_99850	COG3842	ATPase activity
NIES4071_99860	COG0435	Glutathione S-transferase
NIES4071_99910	COG0482	sulfurtransferase activity
NIES4071_99930	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NIES4071_99930	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NIES4071_99940	COG5001	Diguanylate cyclase
NIES4071_99940	COG2203	Gaf domain
NIES4071_99940	COG3706	GGDEF domain
NIES4071_99940	COG4251	negative regulation of phosphorylation
NIES4071_99960	COG0300	oxidoreductase activity
NIES4071_99980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins