locus-tag	class	description
CCON33237_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CCON33237_0002	COG0592	DNA-directed DNA polymerase activity
CCON33237_0003	COG0187	DNA topoisomerase II activity
CCON33237_0004	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CCON33237_0007	COG1749	Flagellar hook protein flgE
CCON33237_0008	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CCON33237_0012	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CCON33237_0017	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CCON33237_0019	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CCON33237_0020	COG0571	ribonuclease III activity
CCON33237_0021	COG0328	RNA-DNA hybrid ribonuclease activity
CCON33237_0023	COG0358	DNA primase activity
CCON33237_0024	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCON33237_0025	COG1473	amidohydrolase
CCON33237_0027	COG3069	C4-dicarboxylate transmembrane transporter activity
CCON33237_0028	COG2195	Cleaves the N-terminal amino acid of tripeptides
CCON33237_0029	COG0482	sulfurtransferase activity
CCON33237_0054	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CCON33237_0069	COG0437	4 iron, 4 sulfur cluster binding
CCON33237_0072	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CCON33237_0094	COG3501	Rhs element vgr protein
CCON33237_0100	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CCON33237_0101	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CCON33237_0102	COG3290	protein histidine kinase activity
CCON33237_0103	COG0745	RESPONSE REGULATOR receiver
CCON33237_0105	COG0352	thiamine-phosphate diphosphorylase activity
CCON33237_0105	COG0351	phosphomethylpyrimidine kinase
CCON33237_0108	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CCON33237_0109	COG0237	dephospho-CoA kinase activity
CCON33237_0110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CCON33237_0111	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CCON33237_0114	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CCON33237_0116	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CCON33237_0116	COG0662	Cupin 2, conserved barrel domain protein
CCON33237_0117	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CCON33237_0118	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCON33237_0119	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CCON33237_0123	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCON33237_0128	COG1215	transferase activity, transferring glycosyl groups
CCON33237_0130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCON33237_0133	COG0463	Glycosyl transferase, family 2
CCON33237_0134	COG1216	Glycosyl transferase, family 2
CCON33237_0137	COG1115	amino acid carrier protein
CCON33237_0138	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CCON33237_0138	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CCON33237_0141	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CCON33237_0142	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCON33237_0143	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CCON33237_0144	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CCON33237_0145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CCON33237_0148	COG0439	Biotin carboxylase
CCON33237_0152	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CCON33237_0153	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CCON33237_0154	COG0268	Binds directly to 16S ribosomal RNA
CCON33237_0155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CCON33237_0159	COG0708	Exodeoxyribonuclease III
CCON33237_0160	COG1716	ATPase activity
CCON33237_0160	COG5001	Diguanylate cyclase
CCON33237_0161	COG1858	cytochrome C peroxidase
CCON33237_0164	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CCON33237_0165	COG1121	(ABC) transporter
CCON33237_0173	COG1971	Probably functions as a manganese efflux pump
CCON33237_0176	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CCON33237_0178	COG0318	PFAM AMP-dependent synthetase and ligase
CCON33237_0180	COG1157	protein secretion by the type III secretion system
CCON33237_0181	COG0302	gtp cyclohydrolase
CCON33237_0182	COG0544	peptidyl-prolyl cis-trans isomerase activity
CCON33237_0183	COG0740	serine-type endopeptidase activity
CCON33237_0185	COG0242	peptide deformylase activity
CCON33237_0186	COG0606	chelatase, subunit chli
CCON33237_0187	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CCON33237_0187	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CCON33237_0188	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CCON33237_0189	COG0861	Integral membrane protein TerC family
CCON33237_0203	COG1007	ATP synthesis coupled electron transport
CCON33237_0204	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCON33237_0205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CCON33237_0206	COG0713	ATP synthesis coupled electron transport
CCON33237_0207	COG0839	Belongs to the complex I subunit 6 family
CCON33237_0208	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCON33237_0209	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CCON33237_0213	COG0649	NAD binding
CCON33237_0215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCON33237_0216	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CCON33237_0217	COG4615	Cyclic peptide transporter
CCON33237_0218	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCON33237_0221	COG1666	GTP binding
CCON33237_0223	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CCON33237_0224	COG0754	glutathionylspermidine amidase activity
CCON33237_0227	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CCON33237_0228	COG0348	domain, Protein
CCON33237_0232	COG1538	Outer membrane efflux protein
CCON33237_0243	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CCON33237_0248	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CCON33237_0249	COG0602	queuosine metabolic process
CCON33237_0253	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CCON33237_0254	COG0254	rRNA binding
CCON33237_0255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CCON33237_0259	COG0436	Aminotransferase
CCON33237_0260	COG0460	homoserine dehydrogenase
CCON33237_0261	COG0792	nuclease activity
CCON33237_0262	COG3118	belongs to the thioredoxin family
CCON33237_0264	COG0492	ferredoxin-NADP+ reductase activity
CCON33237_0265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CCON33237_0267	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CCON33237_0271	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CCON33237_0271	COG0140	phosphoribosyl-ATP diphosphatase activity
CCON33237_0274	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CCON33237_0275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CCON33237_0276	COG1942	4-Oxalocrotonate Tautomerase
CCON33237_0282	COG0444	Belongs to the ABC transporter superfamily
CCON33237_0283	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CCON33237_0284	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CCON33237_0285	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CCON33237_0286	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCON33237_0287	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CCON33237_0288	COG1077	Cell shape determining protein MreB Mrl
CCON33237_0290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CCON33237_0293	COG0505	Belongs to the CarA family
CCON33237_0295	COG0745	RESPONSE REGULATOR receiver
CCON33237_0296	COG3278	Belongs to the heme-copper respiratory oxidase family
CCON33237_0303	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CCON33237_0305	COG1074	ATP-dependent DNA helicase activity
CCON33237_0306	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CCON33237_0307	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CCON33237_0310	COG2081	HI0933 family
CCON33237_0311	COG2814	Major facilitator Superfamily
CCON33237_0312	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CCON33237_0319	COG1116	anion transmembrane transporter activity
CCON33237_0324	COG0314	molybdopterin synthase activity
CCON33237_0330	COG0709	Synthesizes selenophosphate from selenide and ATP
CCON33237_0331	COG0778	Nitroreductase
CCON33237_0332	COG5001	Diguanylate cyclase
CCON33237_0333	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CCON33237_0334	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CCON33237_0338	COG0303	'Molybdopterin
CCON33237_0341	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCON33237_0342	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCON33237_0343	COG0281	malic enzyme
CCON33237_0344	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CCON33237_0346	COG2732	(Barnase) inhibitor
CCON33237_0347	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CCON33237_0351	COG1921	L-seryl-tRNASec selenium transferase activity
CCON33237_0356	COG0437	4 iron, 4 sulfur cluster binding
CCON33237_0357	COG0672	)-iron permease
CCON33237_0362	COG0577	efflux transmembrane transporter activity
CCON33237_0362	COG1136	(ABC) transporter
CCON33237_0367	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CCON33237_0369	COG0180	Tryptophanyl-tRNA synthetase
CCON33237_0371	COG1160	GTP binding
CCON33237_0374	COG2076	Multidrug Resistance protein
CCON33237_0375	COG2076	Multidrug Resistance protein
CCON33237_0378	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CCON33237_0379	COG0284	orotidine-5'-phosphate decarboxylase activity
CCON33237_0395	COG1704	LemA family
CCON33237_0396	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CCON33237_0402	COG1028	Short-chain dehydrogenase reductase Sdr
CCON33237_0403	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CCON33237_0407	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCON33237_0412	COG0824	Thioesterase
CCON33237_0416	COG1058	Belongs to the CinA family
CCON33237_0416	COG1546	Belongs to the CinA family
CCON33237_0417	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CCON33237_0418	COG0154	amidase activity
CCON33237_0419	COG0517	IMP dehydrogenase activity
CCON33237_0419	COG0516	GMP reductase activity
CCON33237_0420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CCON33237_0421	COG1722	exodeoxyribonuclease VII activity
CCON33237_0423	COG2315	Protein conserved in bacteria
CCON33237_0427	COG1193	negative regulation of DNA recombination
CCON33237_0428	COG2199	diguanylate cyclase activity
CCON33237_0428	COG3287	FIST C domain
CCON33237_0428	COG2200	EAL domain
CCON33237_0429	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CCON33237_0434	COG0811	peptide transport
CCON33237_0435	COG0848	biopolymer transport protein
CCON33237_0438	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CCON33237_0439	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CCON33237_0441	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CCON33237_0442	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CCON33237_0443	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CCON33237_0446	COG0351	phosphomethylpyrimidine kinase
CCON33237_0447	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CCON33237_0447	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CCON33237_0448	COG1192	Involved in chromosome partitioning
CCON33237_0449	COG1475	DNA binding
CCON33237_0450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CCON33237_0451	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CCON33237_0452	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CCON33237_0453	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CCON33237_0454	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CCON33237_0455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CCON33237_0456	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CCON33237_0457	COG0811	peptide transport
CCON33237_0458	COG0848	biopolymer transport protein
CCON33237_0460	COG0823	Involved in the tonB-independent uptake of proteins
CCON33237_0463	COG1047	Peptidyl-prolyl cis-trans
CCON33237_0464	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CCON33237_0465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CCON33237_0466	COG0037	tRNA processing
CCON33237_0468	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CCON33237_0470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CCON33237_0471	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CCON33237_0472	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CCON33237_0473	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CCON33237_0474	COG0287	Prephenate dehydrogenase
CCON33237_0476	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CCON33237_0478	COG0083	homoserine kinase activity
CCON33237_0480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CCON33237_0482	COG0779	Required for maturation of 30S ribosomal subunits
CCON33237_0483	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CCON33237_0488	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CCON33237_0489	COG0733	neurotransmitter:sodium symporter activity
CCON33237_0490	COG0733	neurotransmitter:sodium symporter activity
CCON33237_0491	COG0733	neurotransmitter:sodium symporter activity
CCON33237_0494	COG5016	pyruvate
CCON33237_0494	COG0511	ligase activity, forming carbon-carbon bonds
CCON33237_0496	COG1301	dicarboxylic acid transport
CCON33237_0497	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CCON33237_0498	COG0217	transcriptional regulatory protein
CCON33237_0501	COG2217	Heavy metal translocating P-type atpase
CCON33237_0504	COG0165	Argininosuccinate lyase
CCON33237_0506	COG0537	adenosine 5'-monophosphoramidase activity
CCON33237_0509	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CCON33237_0510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CCON33237_0511	COG1185	polyribonucleotide nucleotidyltransferase activity
CCON33237_0511	COG0539	negative regulation of cytoplasmic translation
CCON33237_0513	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CCON33237_0514	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CCON33237_0516	COG0724	RNA recognition motif
CCON33237_0517	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCON33237_0518	COG0616	signal peptide processing
CCON33237_0519	COG0402	S-adenosylhomocysteine deaminase activity
CCON33237_0521	COG0006	proline dipeptidase activity
CCON33237_0522	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CCON33237_0523	COG1419	protein localization to endoplasmic reticulum
CCON33237_0524	COG0455	bacterial-type flagellum organization
CCON33237_0526	COG1191	sigma factor activity
CCON33237_0527	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCON33237_0528	COG1776	CheC inhibitor of MCP methylation
CCON33237_0528	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCON33237_0529	COG1611	Belongs to the LOG family
CCON33237_0530	COG0482	sulfurtransferase activity
CCON33237_0537	COG0437	4 iron, 4 sulfur cluster binding
CCON33237_0541	COG3839	Belongs to the ABC transporter superfamily
CCON33237_0542	COG4662	Binding-protein-dependent transport system inner membrane component
CCON33237_0543	COG2998	abc-type tungstate transport system, permease component
CCON33237_0548	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CCON33237_0552	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CCON33237_0554	COG0563	adenylate kinase activity
CCON33237_0555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CCON33237_0557	COG0497	DNA recombination
CCON33237_0558	COG3706	GGDEF domain
CCON33237_0558	COG0745	RESPONSE REGULATOR receiver
CCON33237_0559	COG0084	hydrolase, TatD family'
CCON33237_0561	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CCON33237_0562	COG0131	Imidazoleglycerol-phosphate dehydratase
CCON33237_0563	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CCON33237_0566	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CCON33237_0568	COG0768	penicillin binding
CCON33237_0569	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CCON33237_0570	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CCON33237_0572	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCON33237_0572	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CCON33237_0574	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CCON33237_0579	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CCON33237_0580	COG1970	mechanosensitive ion channel activity
CCON33237_0584	COG1408	metallophosphoesterase
CCON33237_0585	COG0688	phosphatidylethanolamine metabolic process
CCON33237_0586	COG0012	GTP binding
CCON33237_0587	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CCON33237_0589	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CCON33237_0591	COG0698	ribose 5-phosphate isomerase
CCON33237_0593	COG1994	Peptidase M50
CCON33237_0594	COG0681	Belongs to the peptidase S26 family
CCON33237_0595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CCON33237_0597	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CCON33237_0603	COG2201	protein-glutamate methylesterase activity
CCON33237_0604	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CCON33237_0611	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CCON33237_0612	COG0612	Peptidase, M16
CCON33237_0613	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CCON33237_0615	COG1120	ATPase activity
CCON33237_0618	COG3256	nitric oxide reductase
CCON33237_0621	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CCON33237_0626	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CCON33237_0628	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CCON33237_0629	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CCON33237_0630	COG1049	propionate catabolic process, 2-methylcitrate cycle
CCON33237_0632	COG4221	oxidoreductase activity
CCON33237_0633	COG1757	Na H antiporter
CCON33237_0634	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CCON33237_0635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CCON33237_0637	COG2837	iron assimilation
CCON33237_0639	COG0840	transmembrane signaling receptor activity
CCON33237_0640	COG0840	transmembrane signaling receptor activity
CCON33237_0641	COG0243	molybdopterin cofactor binding
CCON33237_0642	COG0437	4 iron, 4 sulfur cluster binding
CCON33237_0643	COG0348	domain, Protein
CCON33237_0644	COG3043	anaerobic respiration
CCON33237_0654	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CCON33237_0657	COG0501	Belongs to the peptidase M48B family
CCON33237_0660	COG0357	Ribosomal RNA small subunit methyltransferase G
CCON33237_0661	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CCON33237_0662	COG0113	porphobilinogen synthase activity
CCON33237_0663	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CCON33237_0665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCON33237_0670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCON33237_0678	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CCON33237_0679	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CCON33237_0682	COG0250	Participates in transcription elongation, termination and antitermination
CCON33237_0683	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CCON33237_0684	COG0081	regulation of translation
CCON33237_0685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CCON33237_0687	COG0085	RNA polymerase activity
CCON33237_0688	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CCON33237_0691	COG0049	tRNA binding
CCON33237_0692	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CCON33237_0695	COG0783	Belongs to the Dps family
CCON33237_0698	COG4773	Receptor
CCON33237_0700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCON33237_0700	COG1333	cytochrome c biogenesis protein
CCON33237_0703	COG0768	penicillin binding
CCON33237_0705	COG1558	bacterial-type flagellum-dependent cell motility
CCON33237_0706	COG1815	bacterial-type flagellum-dependent cell motility
CCON33237_0708	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CCON33237_0710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CCON33237_0711	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CCON33237_0715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CCON33237_0716	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CCON33237_0717	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CCON33237_0718	COG1862	Preprotein translocase
CCON33237_0719	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCON33237_0720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CCON33237_0722	COG0495	leucyl-tRNA aminoacylation
CCON33237_0724	COG3706	GGDEF domain
CCON33237_0726	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CCON33237_0730	COG1045	serine acetyltransferase
CCON33237_0733	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CCON33237_0736	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CCON33237_0737	COG2176	DNA-directed DNA polymerase activity
CCON33237_0739	COG0733	neurotransmitter:sodium symporter activity
CCON33237_0741	COG2890	protein-(glutamine-N5) methyltransferase activity
CCON33237_0744	COG3610	response to peptide
CCON33237_0746	COG0824	Thioesterase
CCON33237_0749	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CCON33237_0750	COG0594	ribonuclease P activity
CCON33237_0751	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CCON33237_0752	COG0706	membrane insertase activity
CCON33237_0754	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CCON33237_0755	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCON33237_0756	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CCON33237_0758	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CCON33237_0760	COG0138	bifunctional purine biosynthesis protein purh
CCON33237_0764	COG2151	metal-sulfur cluster biosynthetic enzyme
CCON33237_0765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CCON33237_0766	COG0849	cell division
CCON33237_0767	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCON33237_0769	COG0275	rRNA processing
CCON33237_0774	COG1683	Conserved Protein
CCON33237_0777	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CCON33237_0780	COG0653	protein targeting
CCON33237_0781	COG4591	ABC-type transport system involved in lipoprotein release permease component
CCON33237_0783	COG0789	Transcriptional regulator
CCON33237_0784	COG0484	heat shock protein binding
CCON33237_0785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCON33237_0786	COG0745	RESPONSE REGULATOR receiver
CCON33237_0795	COG0142	geranyltranstransferase activity
CCON33237_0796	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CCON33237_0797	COG0442	prolyl-tRNA aminoacylation
CCON33237_0799	COG0181	hydroxymethylbilane synthase activity
CCON33237_0800	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CCON33237_0802	COG0494	nUDIX hydrolase
CCON33237_0803	COG2239	Acts as a magnesium transporter
CCON33237_0804	COG0739	heme binding
CCON33237_0808	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CCON33237_0810	COG0642	Histidine kinase
CCON33237_0811	COG0745	RESPONSE REGULATOR receiver
CCON33237_0816	COG0776	regulation of translation
CCON33237_0817	COG3022	response to hydroperoxide
CCON33237_0818	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CCON33237_0819	COG1196	nuclear chromosome segregation
CCON33237_0819	COG1674	ftsk spoiiie
CCON33237_0822	COG0582	viral genome integration into host DNA
CCON33237_0835	COG2863	cytochrome
CCON33237_0837	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CCON33237_0838	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CCON33237_0838	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CCON33237_0839	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CCON33237_0844	COG2204	response regulator
CCON33237_0845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CCON33237_0847	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CCON33237_0848	COG0731	radical SAM domain protein
CCON33237_0851	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CCON33237_0852	COG0037	tRNA processing
CCON33237_0853	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCON33237_0854	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CCON33237_0855	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CCON33237_0858	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CCON33237_0866	COG2121	Domain of unknown function (DUF374)
CCON33237_0867	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCON33237_0869	COG0195	Participates in both transcription termination and antitermination
CCON33237_0872	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CCON33237_0873	COG2217	Heavy metal translocating P-type atpase
CCON33237_0876	COG0174	glutamine synthetase
CCON33237_0880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CCON33237_0883	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CCON33237_0884	COG0752	glycyl-tRNA synthetase alpha subunit
CCON33237_0885	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CCON33237_0887	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CCON33237_0887	COG1519	Transferase
CCON33237_0888	COG0564	pseudouridine synthase activity
CCON33237_0889	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CCON33237_0890	COG0228	four-way junction DNA binding
CCON33237_0891	COG1837	Belongs to the UPF0109 family
CCON33237_0892	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CCON33237_0894	COG0335	large ribosomal subunit rRNA binding
CCON33237_0896	COG0343	queuine tRNA-ribosyltransferase activity
CCON33237_0897	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CCON33237_0902	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CCON33237_0904	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CCON33237_0905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCON33237_0906	COG0521	Mo-molybdopterin cofactor biosynthetic process
CCON33237_0908	COG0352	thiamine-phosphate diphosphorylase activity
CCON33237_0914	COG1166	arginine decarboxylase activity
CCON33237_0915	COG0124	histidyl-tRNA synthetase
CCON33237_0916	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CCON33237_0917	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CCON33237_0918	COG0163	prenyltransferase activity
CCON33237_0921	COG0303	'Molybdopterin
CCON33237_0922	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CCON33237_0924	COG2833	Protein of unknown function (DUF455)
CCON33237_0926	COG0840	transmembrane signaling receptor activity
CCON33237_0927	COG0840	transmembrane signaling receptor activity
CCON33237_0928	COG1459	type II secretion system
CCON33237_0937	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CCON33237_0938	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CCON33237_0939	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CCON33237_0940	COG0359	binds to the 23S rRNA
CCON33237_0941	COG0137	argininosuccinate synthase activity
CCON33237_0942	COG4771	TonB-dependent receptor
CCON33237_0944	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CCON33237_0945	COG0802	atpase or kinase
CCON33237_0947	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CCON33237_0953	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CCON33237_0954	COG0772	Belongs to the SEDS family
CCON33237_0955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CCON33237_0956	COG0586	Pfam SNARE associated Golgi protein
CCON33237_0957	COG1464	Belongs to the NlpA lipoprotein family
CCON33237_0958	COG1464	Belongs to the NlpA lipoprotein family
CCON33237_0959	COG2011	ABC-type metal ion transport system permease component
CCON33237_0960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CCON33237_0963	COG4953	penicillin-binding protein 1C
CCON33237_0964	COG0210	DNA helicase
CCON33237_0965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CCON33237_0967	COG1538	Outer membrane efflux protein
CCON33237_0970	COG0248	Ppx GppA phosphatase
CCON33237_0972	COG0542	response to heat
CCON33237_0973	COG0793	Belongs to the peptidase S41A family
CCON33237_0974	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CCON33237_0975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CCON33237_0976	COG0047	phosphoribosylformylglycinamidine synthase activity
CCON33237_0978	COG0204	Acyl-transferase
CCON33237_0979	COG0840	transmembrane signaling receptor activity
CCON33237_0980	COG0326	Molecular chaperone. Has ATPase activity
CCON33237_0982	COG2048	Heterodisulfide reductase, subunit B
CCON33237_0983	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CCON33237_0984	COG1053	succinate dehydrogenase
CCON33237_0986	COG1120	ATPase activity
CCON33237_0991	COG3962	Belongs to the TPP enzyme family
CCON33237_0992	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CCON33237_0992	COG0674	pyruvate-flavodoxin oxidoreductase activity
CCON33237_0994	COG0039	L-malate dehydrogenase activity
CCON33237_0996	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CCON33237_0998	COG0375	protein maturation
CCON33237_0999	COG0309	Hydrogenase expression formation protein (HypE)
CCON33237_1000	COG0409	Hydrogenase expression formation protein
CCON33237_1001	COG0298	carbon dioxide binding
CCON33237_1002	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CCON33237_1005	COG0864	Transcriptional regulator
CCON33237_1006	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CCON33237_1008	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CCON33237_1009	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CCON33237_1010	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CCON33237_1011	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CCON33237_1012	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CCON33237_1013	COG0280	phosphate acetyltransferase
CCON33237_1014	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CCON33237_1015	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CCON33237_1016	COG0440	acetolactate synthase activity
CCON33237_1017	COG0028	Belongs to the TPP enzyme family
CCON33237_1018	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CCON33237_1020	COG0134	indole-3-glycerol-phosphate synthase activity
CCON33237_1022	COG0727	PFAM Uncharacterised protein family (UPF0153)
CCON33237_1023	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CCON33237_1025	COG0492	ferredoxin-NADP+ reductase activity
CCON33237_1026	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CCON33237_1030	COG1401	restriction endodeoxyribonuclease activity
CCON33237_1035	COG0356	it plays a direct role in the translocation of protons across the membrane
CCON33237_1036	COG0730	response to heat
CCON33237_1039	COG1256	bacterial-type flagellum assembly
CCON33237_1039	COG4786	Flagellar basal body rod
CCON33237_1042	COG3951	Flagellar rod assembly protein muramidase FlgJ
CCON33237_1047	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CCON33237_1051	COG0585	pseudouridine synthase activity
CCON33237_1052	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CCON33237_1058	COG1181	Belongs to the D-alanine--D-alanine ligase family
CCON33237_1059	COG0632	four-way junction helicase activity
CCON33237_1061	COG0728	peptidoglycan biosynthetic process
CCON33237_1062	COG0215	cysteine-tRNA ligase activity
CCON33237_1063	COG1132	(ABC) transporter
CCON33237_1064	COG0167	dihydroorotate dehydrogenase activity
CCON33237_1066	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CCON33237_1067	COG1028	Short-chain dehydrogenase reductase Sdr
CCON33237_1068	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CCON33237_1069	COG0750	zinc metalloprotease
CCON33237_1070	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CCON33237_1074	COG1942	4-Oxalocrotonate Tautomerase
CCON33237_1075	COG0481	GTPase activity
CCON33237_1103	COG4695	Portal protein
CCON33237_1117	COG2842	Transposition protein
CCON33237_1125	COG1959	2 iron, 2 sulfur cluster binding
CCON33237_1126	COG1596	polysaccharide export
CCON33237_1126	COG1555	photosystem II stabilization
CCON33237_1135	COG1418	mRNA catabolic process
CCON33237_1137	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CCON33237_1138	COG0552	protein localization to endoplasmic reticulum
CCON33237_1140	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CCON33237_1142	COG0736	holo-[acyl-carrier-protein] synthase activity
CCON33237_1143	COG1580	Controls the rotational direction of flagella during chemotaxis
CCON33237_1144	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CCON33237_1146	COG2860	membrane
CCON33237_1156	COG1115	amino acid carrier protein
CCON33237_1158	COG0157	Belongs to the NadC ModD family
CCON33237_1159	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CCON33237_1164	COG0534	Mate efflux family protein
CCON33237_1169	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CCON33237_1170	COG0573	inorganic phosphate transmembrane transporter activity
CCON33237_1172	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CCON33237_1174	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CCON33237_1177	COG0765	amino acid transport
CCON33237_1178	COG4215	(ABC) transporter
CCON33237_1180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCON33237_1182	COG0459	protein refolding
CCON33237_1183	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CCON33237_1186	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CCON33237_1187	COG0556	nucleotide-excision repair
CCON33237_1191	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CCON33237_1192	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CCON33237_1193	COG0305	Participates in initiation and elongation during chromosome replication
CCON33237_1197	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CCON33237_1200	COG1338	Plays a role in the flagellum-specific transport system
CCON33237_1201	COG1360	Flagellar Motor Protein
CCON33237_1202	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CCON33237_1203	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CCON33237_1206	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CCON33237_1207	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CCON33237_1219	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CCON33237_1220	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CCON33237_1221	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CCON33237_1223	COG2171	N-acyltransferase activity
CCON33237_1224	COG3477	response to acidic pH
CCON33237_1227	COG2848	UPF0210 protein
CCON33237_1228	COG3830	Belongs to the UPF0237 family
CCON33237_1229	COG0489	protein tyrosine kinase activity
CCON33237_1230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CCON33237_1231	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CCON33237_1231	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CCON33237_1232	COG0745	RESPONSE REGULATOR receiver
CCON33237_1236	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CCON33237_1238	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CCON33237_1244	COG0751	glycine-tRNA ligase activity
CCON33237_1246	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CCON33237_1247	COG0617	tRNA 3'-terminal CCA addition
CCON33237_1250	COG0473	3-isopropylmalate dehydrogenase activity
CCON33237_1251	COG0066	3-isopropylmalate dehydratase activity
CCON33237_1259	COG0252	asparaginase activity
CCON33237_1260	COG1687	branched-chain amino acid
CCON33237_1263	COG4786	Flagellar basal body rod
CCON33237_1264	COG4786	Flagellar basal body rod
CCON33237_1265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CCON33237_1267	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CCON33237_1271	COG0191	fructose-bisphosphate aldolase activity
CCON33237_1272	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CCON33237_1273	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CCON33237_1274	COG4232	protein-disulfide reductase activity
CCON33237_1277	COG0443	Heat shock 70 kDa protein
CCON33237_1278	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CCON33237_1279	COG1420	regulation of RNA biosynthetic process
CCON33237_1282	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CCON33237_1283	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CCON33237_1285	COG1663	tetraacyldisaccharide 4'-kinase activity
CCON33237_1286	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCON33237_1287	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CCON33237_1288	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CCON33237_1289	COG4773	Receptor
CCON33237_1291	COG0500	methyltransferase
CCON33237_1292	COG1305	Transglutaminase-like
CCON33237_1295	COG2195	Cleaves the N-terminal amino acid of tripeptides
CCON33237_1296	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CCON33237_1297	COG0540	Belongs to the ATCase OTCase family
CCON33237_1301	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CCON33237_1302	COG1959	2 iron, 2 sulfur cluster binding
CCON33237_1303	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CCON33237_1306	COG2890	protein-(glutamine-N5) methyltransferase activity
CCON33237_1307	COG0196	riboflavin kinase activity
CCON33237_1309	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CCON33237_1311	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CCON33237_1314	COG0527	aspartate kinase activity
CCON33237_1317	COG4771	TonB-dependent receptor
CCON33237_1319	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CCON33237_1320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCON33237_1321	COG0805	protein transport
CCON33237_1322	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CCON33237_1324	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CCON33237_1325	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CCON33237_1325	COG0758	DNA mediated transformation
CCON33237_1326	COG2861	carbohydrate metabolic process
CCON33237_1327	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CCON33237_1329	COG0557	exoribonuclease II activity
CCON33237_1331	COG0360	Binds together with S18 to 16S ribosomal RNA
CCON33237_1332	COG0629	single-stranded DNA binding
CCON33237_1333	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CCON33237_1338	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CCON33237_1338	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CCON33237_1339	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CCON33237_1343	COG0628	permease
CCON33237_1345	COG2255	four-way junction helicase activity
CCON33237_1348	COG3301	Polysulphide reductase, NrfD
CCON33237_1349	COG0437	4 iron, 4 sulfur cluster binding
CCON33237_1350	COG0243	molybdopterin cofactor binding
CCON33237_1351	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CCON33237_1352	COG1027	Aspartate ammonia-lyase
CCON33237_1353	COG0488	(ABC) transporter
CCON33237_1354	COG3738	Protein conserved in bacteria
CCON33237_1355	COG0166	Belongs to the GPI family
CCON33237_1357	COG1739	Uncharacterized protein family UPF0029
CCON33237_1359	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CCON33237_1361	COG1053	succinate dehydrogenase
CCON33237_1362	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CCON33237_1363	COG1715	Restriction endonuclease
CCON33237_1364	COG0575	Belongs to the CDS family
CCON33237_1368	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CCON33237_1371	COG0243	molybdopterin cofactor binding
CCON33237_1375	COG0612	Peptidase, M16
CCON33237_1377	COG0840	transmembrane signaling receptor activity
CCON33237_1380	COG1126	abc transporter atp-binding protein
CCON33237_1381	COG0765	amino acid transport
CCON33237_1382	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CCON33237_1383	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CCON33237_1383	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CCON33237_1385	COG2070	2-Nitropropane dioxygenase
CCON33237_1386	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CCON33237_1387	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CCON33237_1388	COG1758	RNA polymerase activity
CCON33237_1389	COG0528	UMP kinase activity
CCON33237_1392	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CCON33237_1393	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CCON33237_1396	COG0564	pseudouridine synthase activity
CCON33237_1397	COG0772	Belongs to the SEDS family
CCON33237_1399	COG0352	thiamine-phosphate diphosphorylase activity
CCON33237_1400	COG0351	phosphomethylpyrimidine kinase
CCON33237_1403	COG3852	Histidine kinase
CCON33237_1406	COG0587	DNA-directed DNA polymerase activity
CCON33237_1408	COG1185	polyribonucleotide nucleotidyltransferase activity
CCON33237_1410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CCON33237_1412	COG0151	Belongs to the GarS family
CCON33237_1414	COG2814	Major facilitator Superfamily
CCON33237_1417	COG0519	Catalyzes the synthesis of GMP from XMP
CCON33237_1426	COG4797	methyltransferase
CCON33237_1426	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CCON33237_1428	COG1570	exodeoxyribonuclease VII activity
CCON33237_1429	COG2226	methyltransferase
CCON33237_1430	COG2954	triphosphatase activity
CCON33237_1432	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CCON33237_1434	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCON33237_1435	COG1766	The M ring may be actively involved in energy transduction
CCON33237_1436	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CCON33237_1437	COG0077	Prephenate dehydratase
CCON33237_1437	COG1605	Chorismate mutase
CCON33237_1438	COG0019	diaminopimelate decarboxylase activity
CCON33237_1440	COG0193	aminoacyl-tRNA hydrolase activity
CCON33237_1441	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CCON33237_1444	COG0835	chemotaxis
CCON33237_1445	COG0643	Histidine kinase
CCON33237_1445	COG2198	Histidine kinase
CCON33237_1446	COG0784	Response regulator, receiver
CCON33237_1446	COG0835	chemotaxis
CCON33237_1448	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CCON33237_1450	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CCON33237_1451	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CCON33237_1452	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CCON33237_1453	COG1183	phosphatidylcholine synthase activity
CCON33237_1454	COG0688	phosphatidylethanolamine metabolic process
CCON33237_1455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CCON33237_1456	COG2264	protein methyltransferase activity
CCON33237_1458	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CCON33237_1459	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CCON33237_1460	COG1086	Polysaccharide biosynthesis protein
CCON33237_1461	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCON33237_1462	COG0110	maltose O-acetyltransferase activity
CCON33237_1463	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCON33237_1464	COG0438	transferase activity, transferring glycosyl groups
CCON33237_1466	COG0438	transferase activity, transferring glycosyl groups
CCON33237_1468	COG0438	transferase activity, transferring glycosyl groups
CCON33237_1469	COG1215	transferase activity, transferring glycosyl groups
CCON33237_1471	COG2244	polysaccharide biosynthetic process
CCON33237_1473	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CCON33237_1477	COG1793	dna ligase
CCON33237_1478	COG0519	Catalyzes the synthesis of GMP from XMP
CCON33237_1481	COG0579	oxidoreductase
CCON33237_1484	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CCON33237_1486	COG0126	phosphoglycerate kinase activity
CCON33237_1489	COG2855	membrane
CCON33237_1490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CCON33237_1491	COG0018	arginyl-trna synthetase
CCON33237_1492	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CCON33237_1493	COG0194	GDP metabolic process
CCON33237_1495	COG1684	flagellar biosynthetic protein fliR
CCON33237_1497	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CCON33237_1498	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CCON33237_1504	COG0859	PFAM glycosyl transferase family 9
CCON33237_1506	COG0463	Glycosyl transferase, family 2
CCON33237_1507	COG0859	PFAM glycosyl transferase family 9
CCON33237_1508	COG0297	glycogen (starch) synthase activity
CCON33237_1508	COG0438	transferase activity, transferring glycosyl groups
CCON33237_1509	COG0726	polysaccharide deacetylase
CCON33237_1512	COG0726	polysaccharide deacetylase
CCON33237_1514	COG1216	Glycosyl transferase, family 2
CCON33237_1514	COG1442	glycosyl transferase family 8
CCON33237_1516	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CCON33237_1518	COG0105	UTP biosynthetic process
CCON33237_1520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CCON33237_1521	COG0416	fatty acid biosynthetic process
CCON33237_1522	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CCON33237_1523	COG0450	alkyl hydroperoxide reductase
CCON33237_1526	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CCON33237_1529	COG0642	Histidine kinase
CCON33237_1532	COG1776	CheC inhibitor of MCP methylation
CCON33237_1532	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CCON33237_1536	COG0135	phosphoribosylanthranilate isomerase activity
CCON33237_1537	COG0512	Glutamine amidotransferase of anthranilate synthase
CCON33237_1537	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CCON33237_1538	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CCON33237_1539	COG2205	protein histidine kinase activity
CCON33237_1540	COG0745	RESPONSE REGULATOR receiver
CCON33237_1541	COG0484	heat shock protein binding
CCON33237_1542	COG0469	pyruvate kinase activity
CCON33237_1543	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CCON33237_1544	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CCON33237_1547	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CCON33237_1552	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CCON33237_1557	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CCON33237_1559	COG1136	(ABC) transporter
CCON33237_1560	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CCON33237_1561	COG0052	Belongs to the universal ribosomal protein uS2 family
CCON33237_1568	COG0825	malonyl-CoA metabolic process
CCON33237_1569	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CCON33237_1570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CCON33237_1572	COG3787	Belongs to the UPF0306 family
CCON33237_1578	COG5001	Diguanylate cyclase
CCON33237_1580	COG2203	Gaf domain
CCON33237_1580	COG3706	GGDEF domain
CCON33237_1580	COG4251	negative regulation of phosphorylation
CCON33237_1580	COG5001	Diguanylate cyclase
CCON33237_1582	COG1607	acyl-coa hydrolase
CCON33237_1587	COG3260	NADH ubiquinone oxidoreductase 20
CCON33237_1589	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CCON33237_1589	COG3261	NADH dehydrogenase
CCON33237_1590	COG0651	ATP synthesis coupled electron transport
CCON33237_1591	COG4237	Hydrogenase 4 membrane
CCON33237_1592	COG0650	Formate hydrogenlyase subunit 4
CCON33237_1593	COG0651	ATP synthesis coupled electron transport
CCON33237_1594	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCON33237_1598	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CCON33237_1599	COG0723	plastoquinol--plastocyanin reductase activity
CCON33237_1600	COG0445	tRNA wobble uridine modification
CCON33237_1601	COG0204	Acyl-transferase
CCON33237_1601	COG0318	PFAM AMP-dependent synthetase and ligase
CCON33237_1602	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCON33237_1603	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CCON33237_1604	COG0765	amino acid transport
CCON33237_1605	COG1126	abc transporter atp-binding protein
CCON33237_1606	COG0716	FMN binding
CCON33237_1609	COG2814	Major facilitator Superfamily
CCON33237_1610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CCON33237_1610	COG1013	pyruvate-flavodoxin oxidoreductase activity
CCON33237_1610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CCON33237_1610	COG0674	pyruvate-flavodoxin oxidoreductase activity
CCON33237_1611	COG3663	DNA glycosylase
CCON33237_1614	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCON33237_1621	COG0534	Mate efflux family protein
CCON33237_1622	COG0439	Biotin carboxylase
CCON33237_1623	COG0511	ligase activity, forming carbon-carbon bonds
CCON33237_1625	COG0717	Belongs to the dCTP deaminase family
CCON33237_1628	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CCON33237_1629	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CCON33237_1630	COG2089	acid synthase
CCON33237_1631	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CCON33237_1634	COG1083	cytidylyl-transferase
CCON33237_1635	COG1028	Short-chain dehydrogenase reductase Sdr
CCON33237_1637	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CCON33237_1638	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CCON33237_1641	COG0475	glutathione-regulated potassium exporter activity
CCON33237_1641	COG0569	domain protein
CCON33237_1642	COG0372	Belongs to the citrate synthase family
CCON33237_1644	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CCON33237_1644	COG4797	methyltransferase
CCON33237_1647	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CCON33237_1649	COG0725	ABC transporter, periplasmic molybdate-binding protein
CCON33237_1655	COG4662	Binding-protein-dependent transport system inner membrane component
CCON33237_1659	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CCON33237_1660	COG1987	bacterial-type flagellum assembly
CCON33237_1663	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CCON33237_1664	COG0148	phosphopyruvate hydratase activity
CCON33237_1667	COG0582	viral genome integration into host DNA
CCON33237_1670	COG1929	Belongs to the glycerate kinase type-1 family
CCON33237_1671	COG2610	gluconate transmembrane transporter activity
CCON33237_1676	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CCON33237_1677	COG4774	siderophore transport
CCON33237_1685	COG0251	oxidation-reduction process
CCON33237_1689	COG1253	flavin adenine dinucleotide binding
CCON33237_1690	COG0733	neurotransmitter:sodium symporter activity
CCON33237_1692	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CCON33237_1696	COG0025	NhaP-type Na H and K H
CCON33237_1703	COG0348	domain, Protein
CCON33237_1706	COG0437	4 iron, 4 sulfur cluster binding
CCON33237_1709	COG4263	nitrous-oxide reductase activity
CCON33237_1711	COG0315	cyclic pyranopterin monophosphate synthase activity
CCON33237_1712	COG2921	Belongs to the UPF0250 family
CCON33237_1714	COG1968	undecaprenyl-diphosphatase activity
CCON33237_1715	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CCON33237_1717	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CCON33237_1718	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CCON33237_1719	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CCON33237_1720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CCON33237_1725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CCON33237_1728	COG0203	ribosomal protein L17
CCON33237_1729	COG0202	RNA polymerase activity
CCON33237_1730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CCON33237_1731	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CCON33237_1732	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CCON33237_1734	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CCON33237_1735	COG0024	Methionine aminopeptidase
CCON33237_1736	COG0201	protein transport
CCON33237_1737	COG0200	Binds to the 23S rRNA
CCON33237_1738	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CCON33237_1739	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CCON33237_1740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CCON33237_1741	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CCON33237_1742	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CCON33237_1743	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CCON33237_1744	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CCON33237_1745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CCON33237_1746	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CCON33237_1747	COG0255	Belongs to the universal ribosomal protein uL29 family
CCON33237_1748	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CCON33237_1749	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CCON33237_1750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CCON33237_1751	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CCON33237_1752	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CCON33237_1753	COG0089	rRNA binding
CCON33237_1754	COG0088	Forms part of the polypeptide exit tunnel
CCON33237_1755	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CCON33237_1756	COG0051	transcription antitermination factor activity, RNA binding
CCON33237_1760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CCON33237_1761	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CCON33237_1762	COG0626	cystathionine gamma-synthase activity
CCON33237_1764	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CCON33237_1766	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CCON33237_1770	COG2203	Gaf domain
CCON33237_1770	COG2199	diguanylate cyclase activity
CCON33237_1771	COG3706	GGDEF domain
CCON33237_1773	COG0668	transmembrane transport
CCON33237_1774	COG0288	reversible hydration of carbon dioxide
CCON33237_1775	COG0670	Belongs to the BI1 family
CCON33237_1776	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CCON33237_1778	COG0233	cytoplasmic translational termination
CCON33237_1785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCON33237_1788	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CCON33237_1791	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CCON33237_1792	COG2249	NAD(P)H dehydrogenase (quinone) activity
CCON33237_1795	COG1271	oxidase subunit
CCON33237_1796	COG1294	oxidase, subunit
CCON33237_1800	COG1322	Protein conserved in bacteria
CCON33237_1802	COG1592	Rubrerythrin
CCON33237_1810	COG1979	alcohol dehydrogenase
CCON33237_1815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CCON33237_1816	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CCON33237_1817	COG0564	pseudouridine synthase activity
CCON33237_1818	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CCON33237_1820	COG0107	imidazoleglycerol-phosphate synthase activity
CCON33237_1822	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CCON33237_1823	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CCON33237_1824	COG0517	IMP dehydrogenase activity
CCON33237_1824	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CCON33237_1825	COG1187	pseudouridine synthase activity
CCON33237_1826	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
CCON33237_1834	COG1333	cytochrome c biogenesis protein
CCON33237_1834	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CCON33237_1835	COG3301	Polysulphide reductase, NrfD
CCON33237_1836	COG0437	4 iron, 4 sulfur cluster binding
CCON33237_1837	COG0545	Peptidyl-prolyl cis-trans isomerase
CCON33237_1838	COG0484	heat shock protein binding
CCON33237_1839	COG3852	Histidine kinase
CCON33237_1840	COG0745	RESPONSE REGULATOR receiver
CCON33237_1841	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CCON33237_1842	COG2056	Na+-H+ antiporter family
CCON33237_1843	COG1749	Flagellar hook protein flgE
CCON33237_1844	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CCON33237_1846	COG1854	S-ribosylhomocysteine lyase activity
CCON33237_1847	COG2258	MOSC domain
CCON33237_1848	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group