locus-tag	class	description
A0Y22_000025	COG2076	Multidrug Resistance protein
A0Y22_000030	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A0Y22_000035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A0Y22_000045	COG2830	Protein of unknown function (DUF452)
A0Y22_000050	COG4106	trans-aconitate 2-methyltransferase activity
A0Y22_000095	COG0454	-acetyltransferase
A0Y22_000120	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0Y22_000135	COG0835	chemotaxis
A0Y22_000135	COG0784	Response regulator, receiver
A0Y22_000140	COG0784	Response regulator, receiver
A0Y22_000140	COG2198	Histidine kinase
A0Y22_000140	COG0643	Histidine kinase
A0Y22_000145	COG0835	chemotaxis
A0Y22_000165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0Y22_000175	COG1077	Cell shape determining protein MreB Mrl
A0Y22_000180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A0Y22_000185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A0Y22_000190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A0Y22_000195	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A0Y22_000200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A0Y22_000205	COG1942	4-Oxalocrotonate Tautomerase
A0Y22_000215	COG0330	HflC and HflK could
A0Y22_000235	COG0243	molybdopterin cofactor binding
A0Y22_000240	COG0428	transporter
A0Y22_000250	COG2226	methyltransferase
A0Y22_000260	COG0418	dihydroorotase activity
A0Y22_000270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A0Y22_000275	COG2194	sulfuric ester hydrolase activity
A0Y22_000280	COG0708	Exodeoxyribonuclease III
A0Y22_000290	COG2921	Belongs to the UPF0250 family
A0Y22_000295	COG0315	cyclic pyranopterin monophosphate synthase activity
A0Y22_000305	COG0477	Major facilitator Superfamily
A0Y22_000330	COG3290	protein histidine kinase activity
A0Y22_000330	COG0840	transmembrane signaling receptor activity
A0Y22_000335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A0Y22_000340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A0Y22_000365	COG0668	transmembrane transport
A0Y22_000370	COG0288	reversible hydration of carbon dioxide
A0Y22_000375	COG0670	Belongs to the BI1 family
A0Y22_000380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A0Y22_000385	COG0233	cytoplasmic translational termination
A0Y22_000390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0Y22_000400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0Y22_000410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A0Y22_000415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A0Y22_000420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A0Y22_000425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A0Y22_000435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A0Y22_000450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A0Y22_000455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0Y22_000460	COG1968	undecaprenyl-diphosphatase activity
A0Y22_000465	COG1297	OPT oligopeptide transporter protein
A0Y22_000470	COG2851	Citrate transporter
A0Y22_000475	COG3843	relaxase mobilization nuclease domain protein
A0Y22_000520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0Y22_000520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A0Y22_000530	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A0Y22_000535	COG1157	protein secretion by the type III secretion system
A0Y22_000540	COG0302	gtp cyclohydrolase
A0Y22_000545	COG0544	peptidyl-prolyl cis-trans isomerase activity
A0Y22_000555	COG0242	peptide deformylase activity
A0Y22_000560	COG0606	chelatase, subunit chli
A0Y22_000570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A0Y22_000570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0Y22_000575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A0Y22_000580	COG0861	Integral membrane protein TerC family
A0Y22_000585	COG2824	Alkylphosphonate utilization operon protein PhnA
A0Y22_000595	COG1253	flavin adenine dinucleotide binding
A0Y22_000600	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A0Y22_000610	COG0848	biopolymer transport protein
A0Y22_000615	COG0811	peptide transport
A0Y22_000620	COG4206	TonB-dependent receptor
A0Y22_000620	COG1629	transport
A0Y22_000635	COG1840	ABC-type Fe3 transport system, periplasmic component
A0Y22_000660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A0Y22_000675	COG1971	Probably functions as a manganese efflux pump
A0Y22_000700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0Y22_000705	COG0602	queuosine metabolic process
A0Y22_000725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A0Y22_000730	COG0254	rRNA binding
A0Y22_000735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A0Y22_000740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A0Y22_000755	COG0436	Aminotransferase
A0Y22_000760	COG0460	homoserine dehydrogenase
A0Y22_000765	COG0792	nuclease activity
A0Y22_000770	COG3118	belongs to the thioredoxin family
A0Y22_000775	COG0492	ferredoxin-NADP+ reductase activity
A0Y22_000795	COG1121	(ABC) transporter
A0Y22_000800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A0Y22_000810	COG1401	restriction endodeoxyribonuclease activity
A0Y22_000835	COG0083	homoserine kinase activity
A0Y22_000860	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A0Y22_000870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A0Y22_000875	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A0Y22_000880	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A0Y22_000890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A0Y22_000915	COG0037	tRNA processing
A0Y22_000920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A0Y22_000925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A0Y22_000930	COG1047	Peptidyl-prolyl cis-trans
A0Y22_000940	COG2885	chlorophyll binding
A0Y22_000945	COG0823	Involved in the tonB-independent uptake of proteins
A0Y22_000955	COG0848	biopolymer transport protein
A0Y22_000960	COG0811	peptide transport
A0Y22_000965	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A0Y22_000970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A0Y22_000985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0Y22_001000	COG1475	DNA binding
A0Y22_001005	COG1192	Involved in chromosome partitioning
A0Y22_001010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A0Y22_001010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A0Y22_001025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0Y22_001030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A0Y22_001035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A0Y22_001065	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A0Y22_001070	COG1027	Aspartate ammonia-lyase
A0Y22_001075	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A0Y22_001080	COG1794	racemase activity, acting on amino acids and derivatives
A0Y22_001085	COG1294	oxidase, subunit
A0Y22_001090	COG1271	oxidase subunit
A0Y22_001105	COG3021	interspecies interaction between organisms
A0Y22_001120	COG0247	lactate metabolic process
A0Y22_001125	COG1139	Iron-sulfur cluster binding protein
A0Y22_001150	COG0616	signal peptide processing
A0Y22_001155	COG0402	S-adenosylhomocysteine deaminase activity
A0Y22_001160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A0Y22_001165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A0Y22_001170	COG1419	protein localization to endoplasmic reticulum
A0Y22_001175	COG0455	bacterial-type flagellum organization
A0Y22_001185	COG1191	sigma factor activity
A0Y22_001190	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0Y22_001195	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0Y22_001195	COG1776	CheC inhibitor of MCP methylation
A0Y22_001225	COG0482	sulfurtransferase activity
A0Y22_001230	COG0471	metal ion transport
A0Y22_001235	COG0471	metal ion transport
A0Y22_001245	COG0471	metal ion transport
A0Y22_001250	COG0471	metal ion transport
A0Y22_001280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A0Y22_001295	COG1217	gtp-binding protein TYPA
A0Y22_001315	COG2814	Major facilitator Superfamily
A0Y22_001365	COG0252	asparaginase activity
A0Y22_001375	COG0504	CTP synthase activity
A0Y22_001390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0Y22_001395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A0Y22_001400	COG0564	pseudouridine synthase activity
A0Y22_001405	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0Y22_001410	COG1858	cytochrome C peroxidase
A0Y22_001415	COG0840	transmembrane signaling receptor activity
A0Y22_001430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A0Y22_001440	COG3477	response to acidic pH
A0Y22_001445	COG0129	dihydroxy-acid dehydratase activity
A0Y22_001450	COG1592	Rubrerythrin
A0Y22_001460	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0Y22_001465	COG0493	'glutamate synthase
A0Y22_001475	COG0069	glutamate synthase activity
A0Y22_001475	COG0067	glutamate synthase
A0Y22_001475	COG0070	glutamate synthase
A0Y22_001480	COG2056	Na+-H+ antiporter family
A0Y22_001495	COG0187	DNA topoisomerase II activity
A0Y22_001500	COG0592	DNA-directed DNA polymerase activity
A0Y22_001505	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A0Y22_001515	COG1749	Flagellar hook protein flgE
A0Y22_001585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A0Y22_001595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A0Y22_001600	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A0Y22_001605	COG1187	pseudouridine synthase activity
A0Y22_001610	COG0051	transcription antitermination factor activity, RNA binding
A0Y22_001615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A0Y22_001620	COG0088	Forms part of the polypeptide exit tunnel
A0Y22_001625	COG0089	rRNA binding
A0Y22_001635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A0Y22_001645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A0Y22_001650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A0Y22_001655	COG0255	Belongs to the universal ribosomal protein uL29 family
A0Y22_001660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A0Y22_001665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A0Y22_001670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A0Y22_001675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A0Y22_001680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A0Y22_001685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A0Y22_001690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A0Y22_001695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A0Y22_001700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A0Y22_001705	COG0200	Binds to the 23S rRNA
A0Y22_001710	COG0201	protein transport
A0Y22_001720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0Y22_001725	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0Y22_001735	COG0372	Belongs to the citrate synthase family
A0Y22_001740	COG1218	3'(2'),5'-bisphosphate nucleotidase
A0Y22_001760	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A0Y22_001765	COG1987	bacterial-type flagellum assembly
A0Y22_001770	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A0Y22_001775	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A0Y22_001780	COG0148	phosphopyruvate hydratase activity
A0Y22_001795	COG1793	dna ligase
A0Y22_001845	COG1136	(ABC) transporter
A0Y22_001870	COG0672	)-iron permease
A0Y22_001880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A0Y22_001885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A0Y22_001890	COG0791	NLP P60 protein
A0Y22_001895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A0Y22_001900	COG0024	Methionine aminopeptidase
A0Y22_001910	COG3218	ABC-type transport auxiliary lipoprotein component
A0Y22_001910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A0Y22_001920	COG1127	ABC transporter
A0Y22_001925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A0Y22_001930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A0Y22_001945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A0Y22_001950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A0Y22_001965	COG0358	DNA primase activity
A0Y22_001975	COG0328	RNA-DNA hybrid ribonuclease activity
A0Y22_001980	COG0571	ribonuclease III activity
A0Y22_001985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A0Y22_002010	COG0848	biopolymer transport protein
A0Y22_002015	COG0811	peptide transport
A0Y22_002030	COG0814	amino acid
A0Y22_002035	COG1760	l-serine dehydratase
A0Y22_002045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0Y22_002045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A0Y22_002075	COG1194	a g-specific adenine glycosylase
A0Y22_002090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A0Y22_002095	COG1120	ATPase activity
A0Y22_002100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0Y22_002105	COG4771	TonB-dependent receptor
A0Y22_002110	COG0748	coenzyme F420 binding
A0Y22_002115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A0Y22_002120	COG0268	Binds directly to 16S ribosomal RNA
A0Y22_002125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A0Y22_002130	COG2046	Belongs to the sulfate adenylyltransferase family
A0Y22_002140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A0Y22_002140	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A0Y22_002145	COG0489	protein tyrosine kinase activity
A0Y22_002150	COG2171	N-acyltransferase activity
A0Y22_002155	COG0140	phosphoribosyl-ATP diphosphatase activity
A0Y22_002155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A0Y22_002170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A0Y22_002180	COG0131	Imidazoleglycerol-phosphate dehydratase
A0Y22_002180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A0Y22_002185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A0Y22_002195	COG0203	ribosomal protein L17
A0Y22_002200	COG0202	RNA polymerase activity
A0Y22_002205	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A0Y22_002210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A0Y22_002220	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A0Y22_002225	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A0Y22_002230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0Y22_002240	COG4615	Cyclic peptide transporter
A0Y22_002250	COG0277	FAD linked oxidase domain protein
A0Y22_002260	COG0601	transmembrane transport
A0Y22_002265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0Y22_002275	COG4608	Belongs to the ABC transporter superfamily
A0Y22_002280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0Y22_002285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0Y22_002290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0Y22_002315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A0Y22_002325	COG0839	Belongs to the complex I subunit 6 family
A0Y22_002335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0Y22_002340	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0Y22_002365	COG0640	Transcriptional regulator
A0Y22_002375	COG1733	regulation of RNA biosynthetic process
A0Y22_002380	COG2910	NAD(P)H-binding
A0Y22_002390	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A0Y22_002410	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A0Y22_002415	COG1064	alcohol dehydrogenase
A0Y22_002425	COG1733	regulation of RNA biosynthetic process
A0Y22_002430	COG2249	NAD(P)H dehydrogenase (quinone) activity
A0Y22_002440	COG1984	allophanate hydrolase subunit 2
A0Y22_002445	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A0Y22_002450	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A0Y22_002455	COG2998	abc-type tungstate transport system, permease component
A0Y22_002460	COG4662	Binding-protein-dependent transport system inner membrane component
A0Y22_002465	COG3839	Belongs to the ABC transporter superfamily
A0Y22_002470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A0Y22_002480	COG0166	Belongs to the GPI family
A0Y22_002485	COG0783	Belongs to the Dps family
A0Y22_002495	COG2992	FlgJ-related protein
A0Y22_002500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A0Y22_002505	COG0237	dephospho-CoA kinase activity
A0Y22_002510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A0Y22_002520	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A0Y22_002530	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A0Y22_002535	COG0303	'Molybdopterin
A0Y22_002540	COG0314	molybdopterin synthase activity
A0Y22_002570	COG3383	formate dehydrogenase (NAD+) activity
A0Y22_002580	COG0437	4 iron, 4 sulfur cluster binding
A0Y22_002590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A0Y22_002620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0Y22_002625	COG0425	Belongs to the sulfur carrier protein TusA family
A0Y22_002640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A0Y22_002660	COG0505	Belongs to the CarA family
A0Y22_002675	COG0745	RESPONSE REGULATOR receiver
A0Y22_002720	COG2887	Belongs to the helicase family. UvrD subfamily
A0Y22_002725	COG0210	DNA helicase
A0Y22_002730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A0Y22_002735	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0Y22_002745	COG0546	phosphoglycolate phosphatase activity
A0Y22_002775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A0Y22_002780	COG1459	type II secretion system
A0Y22_002785	COG0730	response to heat
A0Y22_002810	COG3951	Flagellar rod assembly protein muramidase FlgJ
A0Y22_002815	COG1706	bacterial-type flagellum-dependent cell motility
A0Y22_002835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A0Y22_002840	COG0585	pseudouridine synthase activity
A0Y22_002850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A0Y22_002905	COG0517	IMP dehydrogenase activity
A0Y22_002905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A0Y22_002940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0Y22_002995	COG2226	methyltransferase
A0Y22_003005	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A0Y22_003010	COG1213	nucleotidyl transferase
A0Y22_003015	COG0529	Catalyzes the synthesis of activated sulfate
A0Y22_003035	COG2124	cytochrome p450
A0Y22_003045	COG0736	holo-[acyl-carrier-protein] synthase activity
A0Y22_003050	COG1580	Controls the rotational direction of flagella during chemotaxis
A0Y22_003070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A0Y22_003075	COG0126	phosphoglycerate kinase activity
A0Y22_003080	COG0149	triose-phosphate isomerase activity
A0Y22_003085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A0Y22_003090	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A0Y22_003100	COG1918	ferrous iron import across plasma membrane
A0Y22_003125	COG0251	oxidation-reduction process
A0Y22_003130	COG2964	Protein conserved in bacteria
A0Y22_003140	COG0753	catalase activity
A0Y22_003155	COG0716	FMN binding
A0Y22_003170	COG3276	selenocysteine insertion sequence binding
A0Y22_003175	COG1921	L-seryl-tRNASec selenium transferase activity
A0Y22_003190	COG2814	Major facilitator Superfamily
A0Y22_003195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A0Y22_003210	COG2853	Lipoprotein
A0Y22_003220	COG2252	PERMEase
A0Y22_003225	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A0Y22_003235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0Y22_003245	COG0114	fumarate hydratase activity
A0Y22_003250	COG0628	permease
A0Y22_003255	COG2255	four-way junction helicase activity
A0Y22_003270	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A0Y22_003275	COG3005	denitrification pathway
A0Y22_003280	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A0Y22_003295	COG4607	ABC-type enterochelin transport system periplasmic component
A0Y22_003300	COG4604	ABC transporter, ATP-binding protein
A0Y22_003305	COG4605	iron ion homeostasis
A0Y22_003310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0Y22_003315	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A0Y22_003325	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A0Y22_003335	COG0575	Belongs to the CDS family
A0Y22_003340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A0Y22_003350	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A0Y22_003355	COG2165	general secretion pathway protein
A0Y22_003375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0Y22_003380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0Y22_003405	COG1028	Short-chain dehydrogenase reductase Sdr
A0Y22_003410	COG1083	cytidylyl-transferase
A0Y22_003420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A0Y22_003425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A0Y22_003430	COG2089	acid synthase
A0Y22_003450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A0Y22_003455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0Y22_003465	COG2089	acid synthase
A0Y22_003475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A0Y22_003480	COG0107	imidazoleglycerol-phosphate synthase activity
A0Y22_003485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0Y22_003490	COG3980	spore coat polysaccharide biosynthesis protein
A0Y22_003495	COG1083	cytidylyl-transferase
A0Y22_003540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0Y22_003580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A0Y22_003585	COG1086	Polysaccharide biosynthesis protein
A0Y22_003590	COG0717	Belongs to the dCTP deaminase family
A0Y22_003595	COG0511	ligase activity, forming carbon-carbon bonds
A0Y22_003600	COG0439	Biotin carboxylase
A0Y22_003610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0Y22_003615	COG0280	phosphate acetyltransferase
A0Y22_003615	COG0281	malic enzyme
A0Y22_003620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A0Y22_003625	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A0Y22_003630	COG0569	domain protein
A0Y22_003635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A0Y22_003650	COG0772	Belongs to the SEDS family
A0Y22_003655	COG0564	pseudouridine synthase activity
A0Y22_003665	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A0Y22_003670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0Y22_003685	COG0528	UMP kinase activity
A0Y22_003690	COG1758	RNA polymerase activity
A0Y22_003695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A0Y22_003700	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A0Y22_003715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A0Y22_003715	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A0Y22_003720	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A0Y22_003725	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A0Y22_003730	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A0Y22_003735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A0Y22_003740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A0Y22_003745	COG0642	Histidine kinase
A0Y22_003750	COG0745	RESPONSE REGULATOR receiver
A0Y22_003755	COG0484	heat shock protein binding
A0Y22_003760	COG4773	Receptor
A0Y22_003765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0Y22_003780	COG1942	4-Oxalocrotonate Tautomerase
A0Y22_003790	COG1185	polyribonucleotide nucleotidyltransferase activity
A0Y22_003815	COG0519	Catalyzes the synthesis of GMP from XMP
A0Y22_003815	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0Y22_003825	COG0322	excinuclease ABC activity
A0Y22_003835	COG0731	radical SAM domain protein
A0Y22_003840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A0Y22_003850	COG2814	Major facilitator Superfamily
A0Y22_003860	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A0Y22_003865	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A0Y22_003870	COG0248	Ppx GppA phosphatase
A0Y22_003880	COG0739	heme binding
A0Y22_003885	COG0751	glycine-tRNA ligase activity
A0Y22_003890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A0Y22_003900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A0Y22_003900	COG0475	glutathione-regulated potassium exporter activity
A0Y22_003905	COG0789	Transcriptional regulator
A0Y22_003910	COG0484	heat shock protein binding
A0Y22_003915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0Y22_003920	COG0745	RESPONSE REGULATOR receiver
A0Y22_003925	COG0642	Histidine kinase
A0Y22_003945	COG0745	RESPONSE REGULATOR receiver
A0Y22_003950	COG0642	Histidine kinase
A0Y22_003955	COG0459	protein refolding
A0Y22_003960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A0Y22_003975	COG1496	oxidoreductase activity
A0Y22_003985	COG0739	heme binding
A0Y22_003995	COG0277	FAD linked oxidase domain protein
A0Y22_004000	COG1295	ribonuclease BN
A0Y22_004015	COG1418	mRNA catabolic process
A0Y22_004030	COG0552	protein localization to endoplasmic reticulum
A0Y22_004035	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A0Y22_004050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A0Y22_004055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A0Y22_004070	COG1854	S-ribosylhomocysteine lyase activity
A0Y22_004075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0Y22_004085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0Y22_004100	COG1301	dicarboxylic acid transport
A0Y22_004120	COG0445	tRNA wobble uridine modification
A0Y22_004125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A0Y22_004130	COG0723	plastoquinol--plastocyanin reductase activity
A0Y22_004135	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A0Y22_004145	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A0Y22_004150	COG0052	Belongs to the universal ribosomal protein uS2 family
A0Y22_004155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A0Y22_004165	COG1684	flagellar biosynthetic protein fliR
A0Y22_004175	COG0194	GDP metabolic process
A0Y22_004180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A0Y22_004185	COG0018	arginyl-trna synthetase
A0Y22_004200	COG0217	transcriptional regulatory protein
A0Y22_004205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A0Y22_004220	COG0586	Pfam SNARE associated Golgi protein
A0Y22_004225	COG0039	L-malate dehydrogenase activity
A0Y22_004235	COG3610	response to peptide
A0Y22_004255	COG2217	Heavy metal translocating P-type atpase
A0Y22_004260	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A0Y22_004265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A0Y22_004270	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A0Y22_004275	COG2217	Heavy metal translocating P-type atpase
A0Y22_004290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A0Y22_004295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0Y22_004300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A0Y22_004300	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A0Y22_004305	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A0Y22_004315	COG1216	Glycosyl transferase, family 2
A0Y22_004340	COG2089	acid synthase
A0Y22_004350	COG1442	glycosyl transferase family 8
A0Y22_004350	COG1216	Glycosyl transferase, family 2
A0Y22_004355	COG1442	glycosyl transferase family 8
A0Y22_004355	COG1216	Glycosyl transferase, family 2
A0Y22_004365	COG1442	glycosyl transferase family 8
A0Y22_004365	COG1216	Glycosyl transferase, family 2
A0Y22_004370	COG0463	Glycosyl transferase, family 2
A0Y22_004375	COG1560	Kdo2-lipid A biosynthetic process
A0Y22_004380	COG0859	PFAM glycosyl transferase family 9
A0Y22_004390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A0Y22_004395	COG1132	(ABC) transporter
A0Y22_004400	COG0438	transferase activity, transferring glycosyl groups
A0Y22_004405	COG1215	transferase activity, transferring glycosyl groups
A0Y22_004410	COG0438	transferase activity, transferring glycosyl groups
A0Y22_004415	COG1287	oligosaccharyl transferase activity
A0Y22_004420	COG0438	transferase activity, transferring glycosyl groups
A0Y22_004425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A0Y22_004430	COG0110	maltose O-acetyltransferase activity
A0Y22_004440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A0Y22_004445	COG1086	Polysaccharide biosynthesis protein
A0Y22_004455	COG0745	RESPONSE REGULATOR receiver
A0Y22_004465	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0Y22_004475	COG1183	phosphatidylcholine synthase activity
A0Y22_004480	COG2833	Protein of unknown function (DUF455)
A0Y22_004485	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0Y22_004490	COG2095	MarC family integral membrane protein
A0Y22_004500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A0Y22_004505	COG0542	response to heat
A0Y22_004525	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A0Y22_004540	COG0210	DNA helicase
A0Y22_004555	COG0540	Belongs to the ATCase OTCase family
A0Y22_004560	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A0Y22_004565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A0Y22_004570	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A0Y22_004575	COG1862	Preprotein translocase
A0Y22_004580	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0Y22_004585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0Y22_004590	COG0495	leucyl-tRNA aminoacylation
A0Y22_004605	COG0285	dihydrofolate synthase activity
A0Y22_004610	COG0739	heme binding
A0Y22_004620	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A0Y22_004665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A0Y22_004670	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A0Y22_004680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A0Y22_004685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A0Y22_004690	COG0629	single-stranded DNA binding
A0Y22_004695	COG0360	Binds together with S18 to 16S ribosomal RNA
A0Y22_004700	COG2990	Protein conserved in bacteria
A0Y22_004705	COG0750	zinc metalloprotease
A0Y22_004715	COG0778	Nitroreductase
A0Y22_004720	COG0778	Nitroreductase
A0Y22_004725	COG0456	acetyltransferase
A0Y22_004730	COG1546	Belongs to the CinA family
A0Y22_004730	COG1058	Belongs to the CinA family
A0Y22_004735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A0Y22_004745	COG0154	amidase activity
A0Y22_004750	COG0516	GMP reductase activity
A0Y22_004750	COG0517	IMP dehydrogenase activity
A0Y22_004780	COG1193	negative regulation of DNA recombination
A0Y22_004790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A0Y22_004800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0Y22_004820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0Y22_004825	COG0352	thiamine-phosphate diphosphorylase activity
A0Y22_004850	COG0772	Belongs to the SEDS family
A0Y22_004855	COG0439	Biotin carboxylase
A0Y22_004865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A0Y22_004890	COG0481	GTPase activity
A0Y22_004905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A0Y22_004920	COG2204	response regulator
A0Y22_004925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A0Y22_004975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A0Y22_004975	COG1333	cytochrome c biogenesis protein
A0Y22_005015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0Y22_005020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0Y22_005040	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A0Y22_005045	COG0583	DNA-binding transcription factor activity
A0Y22_005050	COG2855	membrane
A0Y22_005060	COG0357	Ribosomal RNA small subunit methyltransferase G
A0Y22_005065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0Y22_005070	COG0113	porphobilinogen synthase activity
A0Y22_005075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0Y22_005085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0Y22_005090	COG2181	nitrate reductase activity
A0Y22_005090	COG0247	lactate metabolic process
A0Y22_005105	COG2807	transmembrane transport
A0Y22_005115	COG1473	amidohydrolase
A0Y22_005120	COG3022	response to hydroperoxide
A0Y22_005130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0Y22_005135	COG0477	Major facilitator Superfamily
A0Y22_005140	COG2195	Cleaves the N-terminal amino acid of tripeptides
A0Y22_005160	COG0500	methyltransferase
A0Y22_005185	COG0824	Thioesterase
A0Y22_005205	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A0Y22_005215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A0Y22_005220	COG0706	membrane insertase activity
A0Y22_005230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A0Y22_005235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0Y22_005240	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A0Y22_005245	COG0138	bifunctional purine biosynthesis protein purh
A0Y22_005255	COG0840	transmembrane signaling receptor activity
A0Y22_005270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A0Y22_005285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A0Y22_005295	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A0Y22_005300	COG0653	protein targeting
A0Y22_005310	COG0765	amino acid transport
A0Y22_005370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A0Y22_005375	COG0733	neurotransmitter:sodium symporter activity
A0Y22_005380	COG0733	neurotransmitter:sodium symporter activity
A0Y22_005385	COG0511	ligase activity, forming carbon-carbon bonds
A0Y22_005385	COG5016	pyruvate
A0Y22_005390	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A0Y22_005395	COG0165	Argininosuccinate lyase
A0Y22_005400	COG0012	GTP binding
A0Y22_005405	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A0Y22_005415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A0Y22_005430	COG2201	protein-glutamate methylesterase activity
A0Y22_005435	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A0Y22_005440	COG1126	abc transporter atp-binding protein
A0Y22_005445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0Y22_005450	COG0765	amino acid transport
A0Y22_005455	COG0765	amino acid transport
A0Y22_005460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A0Y22_005465	COG1966	Carbon starvation protein
A0Y22_005485	COG0776	regulation of translation
A0Y22_005490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A0Y22_005495	COG1999	signal sequence binding
A0Y22_005520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A0Y22_005525	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A0Y22_005530	COG1115	amino acid carrier protein
A0Y22_005540	COG0765	amino acid transport
A0Y22_005555	COG0537	adenosine 5'-monophosphoramidase activity
A0Y22_005560	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A0Y22_005565	COG0072	phenylalanine-tRNA ligase activity
A0Y22_005565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0Y22_005570	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A0Y22_005575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A0Y22_005580	COG1185	polyribonucleotide nucleotidyltransferase activity
A0Y22_005580	COG0539	negative regulation of cytoplasmic translation
A0Y22_005590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A0Y22_005595	COG0745	RESPONSE REGULATOR receiver
A0Y22_005600	COG5002	protein histidine kinase activity
A0Y22_005605	COG0488	(ABC) transporter
A0Y22_005620	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A0Y22_005625	COG1196	nuclear chromosome segregation
A0Y22_005625	COG1674	ftsk spoiiie
A0Y22_005630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A0Y22_005635	COG1959	2 iron, 2 sulfur cluster binding
A0Y22_005640	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0Y22_005645	COG2404	hydrolase activity, acting on ester bonds
A0Y22_005695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A0Y22_005705	COG0582	viral genome integration into host DNA
A0Y22_005710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A0Y22_005715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0Y22_005715	COG0512	Glutamine amidotransferase of anthranilate synthase
A0Y22_005730	COG0303	'Molybdopterin
A0Y22_005735	COG0681	Belongs to the peptidase S26 family
A0Y22_005780	COG0688	phosphatidylethanolamine metabolic process
A0Y22_005785	COG1408	metallophosphoesterase
A0Y22_005790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0Y22_005815	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A0Y22_005825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0Y22_005825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0Y22_005835	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A0Y22_005840	COG1049	propionate catabolic process, 2-methylcitrate cycle
A0Y22_005850	COG4221	oxidoreductase activity
A0Y22_005855	COG1757	Na H antiporter
A0Y22_005860	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0Y22_005875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A0Y22_005880	COG0101	tRNA pseudouridine synthase activity
A0Y22_005910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A0Y22_005915	COG1338	Plays a role in the flagellum-specific transport system
A0Y22_005930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A0Y22_005945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A0Y22_005950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A0Y22_005955	COG1663	tetraacyldisaccharide 4'-kinase activity
A0Y22_005960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A0Y22_005975	COG1028	Short-chain dehydrogenase reductase Sdr
A0Y22_005980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0Y22_005985	COG0612	Peptidase, M16
A0Y22_005990	COG0167	dihydroorotate dehydrogenase activity
A0Y22_005995	COG1132	(ABC) transporter
A0Y22_006000	COG0215	cysteine-tRNA ligase activity
A0Y22_006005	COG0728	peptidoglycan biosynthetic process
A0Y22_006015	COG0632	four-way junction helicase activity
A0Y22_006020	COG1181	Belongs to the D-alanine--D-alanine ligase family
A0Y22_006045	COG0642	Histidine kinase
A0Y22_006055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0Y22_006060	COG0788	formyltetrahydrofolate deformylase activity
A0Y22_006095	COG3043	anaerobic respiration
A0Y22_006100	COG0348	domain, Protein
A0Y22_006105	COG0437	4 iron, 4 sulfur cluster binding
A0Y22_006115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A0Y22_006125	COG0210	DNA helicase
A0Y22_006140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0Y22_006145	COG2011	ABC-type metal ion transport system permease component
A0Y22_006150	COG1464	Belongs to the NlpA lipoprotein family
A0Y22_006155	COG1464	Belongs to the NlpA lipoprotein family
A0Y22_006160	COG1464	Belongs to the NlpA lipoprotein family
A0Y22_006170	COG0163	prenyltransferase activity
A0Y22_006175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A0Y22_006190	COG1166	arginine decarboxylase activity
A0Y22_006195	COG1045	serine acetyltransferase
A0Y22_006200	COG0436	Aminotransferase
A0Y22_006215	COG0443	Heat shock 70 kDa protein
A0Y22_006220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A0Y22_006225	COG1420	regulation of RNA biosynthetic process
A0Y22_006230	COG4771	TonB-dependent receptor
A0Y22_006240	COG0675	Transposase, IS605 OrfB family
A0Y22_006315	COG3842	ATPase activity
A0Y22_006325	COG1178	ABC-type Fe3 transport system permease component
A0Y22_006350	COG0521	Mo-molybdopterin cofactor biosynthetic process
A0Y22_006360	COG0501	Belongs to the peptidase M48B family
A0Y22_006365	COG2890	protein-(glutamine-N5) methyltransferase activity
A0Y22_006380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A0Y22_006385	COG0587	DNA-directed DNA polymerase activity
A0Y22_006395	COG1393	Belongs to the ArsC family
A0Y22_006400	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A0Y22_006415	COG0336	Belongs to the RNA methyltransferase TrmD family
A0Y22_006420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A0Y22_006425	COG1837	Belongs to the UPF0109 family
A0Y22_006430	COG0228	four-way junction DNA binding
A0Y22_006435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A0Y22_006440	COG0564	pseudouridine synthase activity
A0Y22_006445	COG1519	Transferase
A0Y22_006445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A0Y22_006455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A0Y22_006460	COG0752	glycyl-tRNA synthetase alpha subunit
A0Y22_006470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A0Y22_006475	COG0826	peptidase U32
A0Y22_006485	COG0174	glutamine synthetase
A0Y22_006490	COG4786	Flagellar basal body rod
A0Y22_006495	COG4786	Flagellar basal body rod
A0Y22_006500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A0Y22_006505	COG0849	cell division
A0Y22_006510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0Y22_006515	COG0275	rRNA processing
A0Y22_006540	COG0280	phosphate acetyltransferase
A0Y22_006550	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A0Y22_006560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A0Y22_006580	COG0556	nucleotide-excision repair
A0Y22_006590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A0Y22_006610	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A0Y22_006615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A0Y22_006620	COG1137	ATPase activity
A0Y22_006625	COG0802	atpase or kinase
A0Y22_006630	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A0Y22_006635	COG0137	argininosuccinate synthase activity
A0Y22_006645	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A0Y22_006650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A0Y22_006655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A0Y22_006695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A0Y22_006715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A0Y22_006720	COG1388	LysM domain
A0Y22_006720	COG0791	NLP P60 protein
A0Y22_006725	COG0084	hydrolase, TatD family'
A0Y22_006735	COG0497	DNA recombination
A0Y22_006745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A0Y22_006750	COG0563	adenylate kinase activity
A0Y22_006755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A0Y22_006760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A0Y22_006775	COG0758	DNA mediated transformation
A0Y22_006785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A0Y22_006790	COG0557	exoribonuclease II activity
A0Y22_006805	COG0375	protein maturation
A0Y22_006810	COG0309	Hydrogenase expression formation protein (HypE)
A0Y22_006815	COG0409	Hydrogenase expression formation protein
A0Y22_006820	COG0298	carbon dioxide binding
A0Y22_006830	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A0Y22_006845	COG0534	Mate efflux family protein
A0Y22_006860	COG0581	inorganic phosphate transmembrane transporter activity
A0Y22_006865	COG0573	inorganic phosphate transmembrane transporter activity
A0Y22_006870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A0Y22_006875	COG1528	Iron-storage protein
A0Y22_006880	COG1696	Membrane protein involved in D-alanine export
A0Y22_006895	COG1538	Outer membrane efflux protein
A0Y22_006900	COG1136	(ABC) transporter
A0Y22_006900	COG0577	efflux transmembrane transporter activity
A0Y22_006905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0Y22_006910	COG1473	amidohydrolase
A0Y22_006925	COG2258	MOSC domain
A0Y22_006930	COG0733	neurotransmitter:sodium symporter activity
A0Y22_006950	COG0191	fructose-bisphosphate aldolase activity
A0Y22_006955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A0Y22_006960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A0Y22_006970	COG2860	membrane
A0Y22_006985	COG2890	protein-(glutamine-N5) methyltransferase activity
A0Y22_006990	COG0196	riboflavin kinase activity
A0Y22_007005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0Y22_007010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A0Y22_007025	COG0527	aspartate kinase activity
A0Y22_007030	COG0494	nUDIX hydrolase
A0Y22_007035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0Y22_007045	COG0805	protein transport
A0Y22_007050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A0Y22_007060	COG0440	acetolactate synthase activity
A0Y22_007065	COG0028	Belongs to the TPP enzyme family
A0Y22_007070	COG1610	YqeY-like protein
A0Y22_007075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0Y22_007075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0Y22_007120	COG4735	regulation of single-species biofilm formation
A0Y22_007125	COG4735	regulation of single-species biofilm formation
A0Y22_007140	COG0305	Participates in initiation and elongation during chromosome replication
A0Y22_007155	COG0492	ferredoxin-NADP+ reductase activity
A0Y22_007160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A0Y22_007165	COG1289	transmembrane transporter activity
A0Y22_007195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A0Y22_007215	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A0Y22_007225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A0Y22_007230	COG0181	hydroxymethylbilane synthase activity
A0Y22_007245	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A0Y22_007250	COG0142	geranyltranstransferase activity
A0Y22_007270	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0Y22_007275	COG0674	pyruvate-flavodoxin oxidoreductase activity
A0Y22_007275	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A0Y22_007285	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A0Y22_007295	COG0039	L-malate dehydrogenase activity
A0Y22_007315	COG1815	bacterial-type flagellum-dependent cell motility
A0Y22_007320	COG1558	bacterial-type flagellum-dependent cell motility
A0Y22_007325	COG1677	Flagellar hook-basal body complex protein FliE
A0Y22_007345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0Y22_007360	COG0204	Acyl-transferase
A0Y22_007370	COG0047	phosphoribosylformylglycinamidine synthase activity
A0Y22_007375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0Y22_007385	COG0793	Belongs to the peptidase S41A family
A0Y22_007390	COG1937	Protein conserved in bacteria
A0Y22_007395	COG0542	response to heat
A0Y22_007405	COG0424	maF-like protein
A0Y22_007420	COG0673	inositol 2-dehydrogenase activity
A0Y22_007425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A0Y22_007435	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A0Y22_007480	COG0049	tRNA binding
A0Y22_007485	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A0Y22_007495	COG3254	rhamnose metabolic process
A0Y22_007505	COG0738	Major facilitator superfamily
A0Y22_007510	COG1028	Short-chain dehydrogenase reductase Sdr
A0Y22_007520	COG2721	sulfolactate sulfo-lyase activity
A0Y22_007530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0Y22_007540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A0Y22_007545	COG0085	RNA polymerase activity
A0Y22_007550	COG0222	ribosome binding
A0Y22_007555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A0Y22_007560	COG0081	regulation of translation
A0Y22_007565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A0Y22_007570	COG0250	Participates in transcription elongation, termination and antitermination
A0Y22_007585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A0Y22_007590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A0Y22_007620	COG0765	amino acid transport
A0Y22_007635	COG2346	COG2346, Truncated hemoglobins
A0Y22_007640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A0Y22_007645	COG0612	Peptidase, M16
A0Y22_007650	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A0Y22_007660	COG0195	Participates in both transcription termination and antitermination
A0Y22_007670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0Y22_007675	COG2121	Domain of unknown function (DUF374)
A0Y22_007705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A0Y22_007710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A0Y22_007730	COG4771	TonB-dependent receptor
A0Y22_007740	COG4771	TonB-dependent receptor
A0Y22_007745	COG0825	malonyl-CoA metabolic process
A0Y22_007750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A0Y22_007755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A0Y22_007760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A0Y22_007765	COG2048	Heterodisulfide reductase, subunit B
A0Y22_007770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A0Y22_007775	COG1053	succinate dehydrogenase
A0Y22_007785	COG1028	Short-chain dehydrogenase reductase Sdr
A0Y22_007790	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A0Y22_007795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0Y22_007800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A0Y22_007840	COG1739	Uncharacterized protein family UPF0029
A0Y22_007855	COG0488	(ABC) transporter
A0Y22_007885	COG2353	YceI-like domain
A0Y22_007930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A0Y22_007935	COG1053	succinate dehydrogenase
A0Y22_007955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A0Y22_007970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A0Y22_007975	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A0Y22_008010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A0Y22_008015	COG0579	oxidoreductase
A0Y22_008020	COG0469	pyruvate kinase activity
A0Y22_008035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A0Y22_008065	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A0Y22_008075	COG0284	orotidine-5'-phosphate decarboxylase activity
A0Y22_008085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A0Y22_008090	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
A0Y22_008095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0Y22_008110	COG1666	GTP binding
A0Y22_008115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0Y22_008120	COG0754	glutathionylspermidine amidase activity
A0Y22_008130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A0Y22_008145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A0Y22_008155	COG1538	Outer membrane efflux protein
A0Y22_008165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A0Y22_008170	COG1981	membrane
A0Y22_008175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A0Y22_008190	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A0Y22_008200	COG0745	RESPONSE REGULATOR receiver
A0Y22_008205	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0Y22_008220	COG1776	CheC inhibitor of MCP methylation
A0Y22_008220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0Y22_008235	COG0133	tryptophan synthase activity
A0Y22_008245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A0Y22_008245	COG0512	Glutamine amidotransferase of anthranilate synthase
A0Y22_008260	COG0730	response to heat
A0Y22_008265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A0Y22_008270	COG1238	metal cluster binding
A0Y22_008280	COG0477	Major facilitator Superfamily
A0Y22_008290	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A0Y22_008295	COG1360	Flagellar Motor Protein
A0Y22_008300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A0Y22_008305	COG0450	alkyl hydroperoxide reductase
A0Y22_008315	COG0105	UTP biosynthetic process
A0Y22_008325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A0Y22_008330	COG0416	fatty acid biosynthetic process
A0Y22_008335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0Y22_008340	COG0251	oxidation-reduction process
A0Y22_008345	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A0Y22_008350	COG1570	exodeoxyribonuclease VII activity
A0Y22_008355	COG2226	methyltransferase
A0Y22_008370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A0Y22_008380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A0Y22_008390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0Y22_008405	COG0019	diaminopimelate decarboxylase activity