locus-tag	class	description
IM45_001	ENOG4105DWT	malate dehydrogenase (quinone)
IM45_003	ENOG4108Z6B	deaminase
IM45_005	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
IM45_007	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
IM45_013	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
IM45_015	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
IM45_017	ENOG4105CUT	histidyl-tRNA synthetase
IM45_019	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
IM45_021	ENOG4107QP8	phosphohexose isomerase
IM45_023	ENOG4105XFK	Ferrous iron transport protein A
IM45_025	ENOG4105CE1	Ferrous iron transport protein b
IM45_029	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
IM45_031	ENOG4107RK2	ADP-ribose diphosphatase NudE
IM45_033	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
IM45_035	ENOG4105DZ2	Transcriptional regulator
IM45_037	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
IM45_039	ENOG4105CGY	Dna recombination protein
IM45_041	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
IM45_043	ENOG4105JC1	sterol-binding domain protein
IM45_045	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
IM45_047	ENOG4105CVG	Homoserine O-transsuccinylase
IM45_049	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
IM45_051	ENOG4105E55	glycerol-3-phosphate acyltransferase
IM45_053	ENOG4105C31	Tryptophanyl-tRNA synthetase
IM45_055	ENOG4105DJV	ribulose-phosphate 3-epimerase
IM45_057	ENOG4105D49	3-dehydroquinate synthase
IM45_059	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
IM45_061	ENOG4105JIM	Phosphatidylserine synthase
IM45_063	ENOG4106W5V	Membrane
IM45_065	ENOG4107RGD	Major Facilitator superfamily
IM45_067	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
IM45_068	ENOG4105W4M	Transport-associated protein
IM45_071	ENOG4105VFK	BolA family
IM45_073	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
IM45_075	ENOG4105C0H	protease
IM45_077	ENOG4108W2Q	Cytochrome d ubiquinol oxidase subunit III
IM45_079	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
IM45_081	ENOG4108UJD	30S ribosomal protein S9
IM45_085	ENOG4108P1K	Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)
IM45_086	ENOG4105WI0	lipopolysaccharide transport periplasmic protein lptA
IM45_089	ENOG4108IUZ	ABC transporter
IM45_095	ENOG4105DC1	bifunctional purine biosynthesis protein purh
IM45_097	ENOG4105C12	Phosphoribosylglycinamide synthetase
IM45_1000	ENOG4105ETZ	PTS System
IM45_1002	ENOG4108EQA	pts system
IM45_1004	ENOG4105EE5	Membrane protein terC
IM45_1008	ENOG4105C72	UPF0176 protein
IM45_101	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
IM45_1011	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
IM45_1015	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
IM45_1017	ENOG4105CW7	secretion protein, HlyD family
IM45_1019	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
IM45_1021	ENOG4105JRK	feS assembly protein SufD
IM45_1022	ENOG4105C3K	feS assembly ATPase SufC
IM45_1025	ENOG4105C9B	Cysteine desulfurase
IM45_1027	ENOG4108Z4V	iron-sulfur cluster assembly
IM45_1029	ENOG4105DIW	FeS assembly protein SUFB
IM45_103	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
IM45_1031	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
IM45_1033	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
IM45_1035	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
IM45_1037	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
IM45_1039	ENOG41082NX	50s ribosomal protein l35
IM45_104	ENOG4105D06	uba thif-type nad fad binding protein
IM45_1041	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
IM45_1043	ENOG4105C22	threonyL-tRNA synthetase
IM45_1045	ENOG4108JDX	DNA polymerase iii, epsilon subunit
IM45_1047	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
IM45_1049	ENOG4105D1A	Methyltransferase
IM45_1051	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
IM45_1055	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
IM45_1057	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
IM45_1059	ENOG4105CSA	Coproporphyrinogen iii oxidase
IM45_1061	ENOG4108VIA	integral membrane protein
IM45_1063	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
IM45_1064	ENOG4108UJU	UPF0301 protein
IM45_1067	ENOG4105D7Z	glutathione synthase
IM45_1069	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
IM45_107	ENOG4105WHD	thiamine biosynthesis protein ThiS
IM45_1071	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
IM45_1077	ENOG4105MYN	Zinc uptake regulation protein
IM45_1079	ENOG4108ZAT	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)
IM45_1081	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
IM45_1083	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
IM45_1085	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
IM45_1087	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
IM45_1089	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
IM45_109	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
IM45_1091	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
IM45_1093	ENOG4105PM1	preprotein translocase subunit SecE
IM45_1094	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
IM45_1097	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
IM45_1099	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
IM45_110	ENOG4105D41	biosynthesis protein thiH
IM45_1101	ENOG4108VZM	50s ribosomal protein L10
IM45_1103	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
IM45_1105	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IM45_1107	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IM45_1109	ENOG4105D4A	Cell wall formation (By similarity)
IM45_1110	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
IM45_1117	ENOG4107QN2	dihydrolipoyl dehydrogenase
IM45_1119	ENOG4107QSN	dihydrolipoamide acetyltransferase
IM45_1121	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
IM45_1123	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
IM45_1125	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
IM45_1127	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
IM45_113	ENOG4105VQ7	Rod shape-determining protein MreD
IM45_1131	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IM45_1133	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
IM45_1135	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
IM45_1137	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
IM45_1139	ENOG4105DFU	Cell wall formation (By similarity)
IM45_1141	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
IM45_1142	ENOG4105CNI	cell division protein FtsW
IM45_1143	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
IM45_1147	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
IM45_1148	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
IM45_1149	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
IM45_115	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
IM45_1153	ENOG4105CJN	penicillin-binding protein
IM45_1155	ENOG41063Y6	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
IM45_1157	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
IM45_1159	ENOG4107R1K	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
IM45_1161	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
IM45_1165	ENOG4105CE9	30S ribosomal protein S2
IM45_1167	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
IM45_1169	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
IM45_117	ENOG4105DFF	Rod shape-determining protein mreb
IM45_1171	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
IM45_1173	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
IM45_1175	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
IM45_1177	ENOG4105KNE	Phosphatidate cytidylyltransferase
IM45_1179	ENOG4105DZP	Membrane-associated zinc metalloprotease
IM45_1180	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM45_1183	ENOG4108RFI	Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)
IM45_1185	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IM45_1187	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
IM45_1189	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IM45_119	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
IM45_1191	ENOG4105C0B	DNA polymerase III (alpha subunit)
IM45_1193	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
IM45_1195	ENOG4105C28	cystathionine
IM45_1197	ENOG4105IRT	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)
IM45_1199	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
IM45_1201	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
IM45_1203	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
IM45_1205	ENOG4105DSY	exodeoxyribonuclease V, gamma
IM45_1207	ENOG4107QKA	exodeoxyribonuclease V beta
IM45_1209	ENOG4107QYX	exodeoxyribonuclease v alpha
IM45_121	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
IM45_1215	ENOG4105CDU	Replicative dna helicase
IM45_1217	ENOG4105CFG	Acts as a chaperone (By similarity)
IM45_1219	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
IM45_1221	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
IM45_1223	ENOG4105DTN	riboflavin biosynthesis protein ribF
IM45_1224	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
IM45_1225	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
IM45_1229	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
IM45_123	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
IM45_1231	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
IM45_1233	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
IM45_1235	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
IM45_1237	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
IM45_1239	ENOG4105NWN	ApaG protein
IM45_1241	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
IM45_1242	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
IM45_1245	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
IM45_125	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
IM45_1250	ENOG4105VDB	UPF0125 protein
IM45_1251	ENOG4108Z1B	Cyclase dehydrase
IM45_1254	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
IM45_1257	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
IM45_1259	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
IM45_1261	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
IM45_1263	ENOG4108VDV	Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity)
IM45_1265	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
IM45_1267	ENOG4105C2N	RNA methyltransferase TrmH family group 3
IM45_1269	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
IM45_127	ENOG41082NP	Multiple antibiotic resistance
IM45_1271	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
IM45_1273	ENOG4105EPW	hflc protein
IM45_1275	ENOG4107QJR	hflk protein
IM45_1277	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
IM45_1279	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
IM45_1281	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
IM45_1283	ENOG4105K8N	protein family UPF0079, ATPase
IM45_1285	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
IM45_1287	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
IM45_1289	ENOG4105DJ4	phosphatidylserine decarboxylase
IM45_129	ENOG4105DGW	oligopeptidase A
IM45_1291	ENOG4105EGS	Mechanosensitive ion channel
IM45_1293	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
IM45_1295	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
IM45_1297	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
IM45_1302	ENOG4105KF5	hemolysin expression-modulating protein
IM45_1304	ENOG4105D3R	alkyl hydroperoxide reductase
IM45_1306	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
IM45_1308	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
IM45_131	ENOG4105CJ3	phosphate transporter
IM45_1310	ENOG4105VIE	preprotein translocase, subunit YajC
IM45_1312	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
IM45_1314	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
IM45_1316	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
IM45_1318	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
IM45_1320	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
IM45_1322	ENOG4107YIM	Involved in the transcription termination process (By similarity)
IM45_1324	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
IM45_1325	ENOG4108ZAI	phosphatidylglycerophosphatase a
IM45_1328	ENOG4105CFU	surface antigen
IM45_1332	ENOG4105F0N	pyrophosphate phospho-hydrolase
IM45_1335	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
IM45_1338	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
IM45_1340	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IM45_1342	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
IM45_1344	ENOG4108IYU	L-aspartate oxidase
IM45_1347	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
IM45_1349	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
IM45_135	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
IM45_1351	ENOG4105VCC	30S ribosomal protein S21
IM45_1353	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
IM45_1355	ENOG4107ZVW	dihydroneopterin aldolase
IM45_1357	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
IM45_1359	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
IM45_1361	ENOG4105W0Z	cytoplasmic protein
IM45_1363	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
IM45_1365	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
IM45_1367	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
IM45_1369	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
IM45_137	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
IM45_1371	ENOG4108WPU	DNA polymerase III subunit psi
IM45_1373	ENOG4105C1J	atp-dependent rna helicase
IM45_1375	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
IM45_1377	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
IM45_1379	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
IM45_1381	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
IM45_1383	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
IM45_1385	ENOG4105CHV	Transcription elongation factor NusA
IM45_139	ENOG4105CAK	Cell division ATP-binding protein ftsE
IM45_1391	ENOG4105EEI	dihydropteroate synthase
IM45_1393	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
IM45_1395	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
IM45_1397	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
IM45_1399	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
IM45_140	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
IM45_1401	ENOG4106HRJ	d-alanyl-d-alanine carboxypeptidase
IM45_1403	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IM45_1405	ENOG4105K46	50S ribosomal protein l27
IM45_1407	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
IM45_1409	ENOG4105EAH	synthase
IM45_1411	ENOG4105BZA	Phosphoglycerate kinase
IM45_1413	ENOG4105D2N	Aldolase
IM45_1415	ENOG4105E66	phosphoriboisomerase A
IM45_1417	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
IM45_1419	ENOG4107YUN	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)
IM45_1421	ENOG4105D0A	hydroxylase
IM45_1423	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
IM45_1425	ENOG4105DWF	phosphomethylpyrimidine kinase
IM45_1427	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
IM45_1429	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
IM45_145	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
IM45_147	ENOG4107QK7	reductase
IM45_149	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
IM45_150	ENOG41076E6	Uroporphyrinogen-III Synthase
IM45_153	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
IM45_155	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
IM45_157	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
IM45_159	ENOG4105EAK	ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family
IM45_161	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
IM45_163	ENOG4107NPY	receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity)
IM45_167	ENOG4105C6T	cysteine synthase
IM45_169	ENOG4105KZ7	phosphocarrier protein hpr
IM45_173	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
IM45_175	ENOG4105C8V	SAICAR synthetase
IM45_177	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
IM45_179	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
IM45_181	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
IM45_183	ENOG4105CV1	Transketolase (EC 2.2.1.1)
IM45_185	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
IM45_187	ENOG4108I5D	sulfate abc transporter
IM45_189	ENOG4105ECW	sulfate abc transporter
IM45_193	ENOG410814C	multidrug resistance protein
IM45_195	ENOG4108R3D	Electron transport complex
IM45_197	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
IM45_199	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
IM45_201	ENOG4108US0	Transcription regulator that can specifically activate or repress expression of target genes (By similarity)
IM45_205	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
IM45_207	ENOG4105M2J	Glutaredoxin
IM45_209	ENOG4108R6K	riboflavin synthase, subunit alpha
IM45_216	ENOG4105CX6	glutaminyL-tRNA synthetase
IM45_218	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
IM45_220	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
IM45_221	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
IM45_224	ENOG4107QNR	UPF0135 protein
IM45_226	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
IM45_228	ENOG4105E02	MotA TolQ exbB proton channel
IM45_230	ENOG4105M8F	Biopolymer transport protein exbD tolR
IM45_232	ENOG4108Z82	Cell envelope integrity inner membrane protein TolA
IM45_234	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
IM45_236	ENOG4105KCK	Peptidoglycan-associated lipoprotein
IM45_238	ENOG4105UFD	tol-pal system protein YbgF
IM45_240	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
IM45_242	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
IM45_244	ENOG4105EEQ	Na H antiporter
IM45_248	ENOG4105CC5	ABC transporter
IM45_250	ENOG4105DIK	(ABC) transporter
IM45_252	ENOG4108UUM	single-stranded DNA-binding protein
IM45_256	ENOG4105CK2	sodium dicarboxylate symporter
IM45_258	ENOG41090MY	MarR family Transcriptional regulator
IM45_260	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
IM45_262	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
IM45_264	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
IM45_266	ENOG4105CB5	ATP-dependent DNA helicase recG
IM45_268	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
IM45_270	ENOG4105C2M	dna polymerase I
IM45_272	ENOG4107QMP	dna polymerase iii subunits gamma and tau
IM45_274	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
IM45_276	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
IM45_278	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
IM45_280	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
IM45_282	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
IM45_284	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
IM45_286	ENOG4105C8N	cysteinyl-tRNA synthetase
IM45_288	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
IM45_291	ENOG4105BZU	Histidine kinase
IM45_295	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
IM45_297	ENOG4105DFC	had-superfamily hydrolase, subfamily ia, variant
IM45_299	ENOG4105C4R	Atp-dependent dna helicase
IM45_301	ENOG4107QUT	magnesium and cobalt transport protein CorA
IM45_305	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IM45_307	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
IM45_309	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
IM45_313	ENOG4105VG0	50S ribosomal protein l34
IM45_315	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
IM45_319	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
IM45_320	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
IM45_323	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
IM45_325	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
IM45_327	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
IM45_329	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
IM45_331	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
IM45_333	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
IM45_335	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
IM45_337	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
IM45_339	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
IM45_341	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
IM45_343	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
IM45_345	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
IM45_347	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
IM45_349	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
IM45_351	ENOG4105CRK	lysyL-tRNA synthetase
IM45_353	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
IM45_361	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
IM45_363	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
IM45_365	ENOG4107R9T	Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity)
IM45_367	ENOG4105SYT	Methylenetetrahydrofolate reductase
IM45_370	ENOG4105GGQ	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)
IM45_372	ENOG41082DI	50s ribosomal protein l31
IM45_374	ENOG4105C25	Primosomal protein n'
IM45_376	ENOG41063M6	Cell Division Protein
IM45_377	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
IM45_379	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
IM45_381	ENOG4105CP7	Triose-phosphate isomerase
IM45_383	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
IM45_385	ENOG4105CTQ	phosphohexokinase
IM45_387	ENOG4105D7W	serine acetyltransferase
IM45_389	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
IM45_391	ENOG4105VW4	glutaredoxin 3
IM45_393	ENOG4107YZP	Rhodanese domain protein
IM45_395	ENOG41063SB	peptidase
IM45_397	ENOG4105PXI	polysaccharide deacetylase
IM45_399	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
IM45_401	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
IM45_403	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
IM45_405	ENOG4105W0E	50S ribosomal protein L33
IM45_407	ENOG4105KDC	50s ribosomal protein l28
IM45_409	ENOG4105DSJ	YicC domain protein
IM45_411	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
IM45_413	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
IM45_414	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
IM45_421	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
IM45_425	ENOG4105DAD	Could be involved in ECA polysaccharide chain elongation (By similarity)
IM45_427	ENOG4105EGZ	biosynthesis protein
IM45_429	ENOG4108WJ1	acetyltransferase
IM45_430	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
IM45_431	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
IM45_432	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
IM45_433	ENOG4108IJ1	Dehydrogenase
IM45_434	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
IM45_441	ENOG4105ESV	Glycosyl transferase, family 4
IM45_443	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
IM45_445	ENOG4105K63	Thioredoxin
IM45_447	ENOG4108WFC	UPF0438 protein yifE
IM45_449	ENOG4105CVI	Transcriptional regulator
IM45_451	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
IM45_453	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM45_455	ENOG4105C34	Pseudouridine synthase
IM45_457	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
IM45_459	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
IM45_461	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
IM45_463	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
IM45_465	ENOG4105K5M	30s ribosomal protein S16
IM45_467	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IM45_469	ENOG4105D9M	gamma-glutamylcysteine synthetase
IM45_473	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
IM45_475	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
IM45_477	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
IM45_479	ENOG4105EAB	amino acid AbC transporter
IM45_481	ENOG4105DRP	amino acid AbC transporter
IM45_483	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
IM45_485	ENOG4108K5P	(LipO)protein
IM45_487	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
IM45_488	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
IM45_489	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
IM45_493	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
IM45_494	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
IM45_498	ENOG4105C11	sulfate adenylyltransferase), subunit 2
IM45_499	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
IM45_501	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
IM45_503	ENOG4107QHM	Sulfite reductase
IM45_504	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
IM45_507	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
IM45_509	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
IM45_511	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
IM45_513	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
IM45_515	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
IM45_517	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
IM45_519	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
IM45_521	ENOG4105BZ4	penicillin-binding protein
IM45_523	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IM45_525	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IM45_527	ENOG4105DJ0	Poly(A) Polymerase
IM45_529	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
IM45_531	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
IM45_533	ENOG4105C8T	Leucyl-tRNA synthetase
IM45_535	ENOG4108U2H	Rare lipoprotein B
IM45_536	ENOG4105DJF	DNA polymerase III, delta' subunit
IM45_537	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
IM45_541	ENOG4105CJN	penicillin-binding protein
IM45_542	ENOG4105CNI	cell division protein FtsW
IM45_545	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
IM45_547	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
IM45_549	ENOG4105EV4	Multidrug resistance protein mdtH
IM45_551	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
IM45_556	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
IM45_558	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
IM45_560	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
IM45_561	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
IM45_562	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
IM45_564	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
IM45_568	ENOG4105CHW	UPF0052 protein
IM45_570	ENOG4105CDA	abc transporter atp-binding protein
IM45_572	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
IM45_574	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
IM45_576	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
IM45_578	ENOG4105CAT	Cytidine monophosphate kinase
IM45_580	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
IM45_582	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
IM45_586	ENOG4105BZ1	(ABC) transporter
IM45_589	ENOG4105W49	UPF0434 protein
IM45_591	ENOG4108Z33	Thiol disulfide Interchange Protein
IM45_595	ENOG4105CXT	aspartate transcarbamylase
IM45_597	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
IM45_599	ENOG4105KME	endoribonuclease L-psp
IM45_601	ENOG4105VEQ	Cold shock protein
IM45_603	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
IM45_605	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
IM45_607	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
IM45_609	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
IM45_611	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
IM45_613	ENOG4105M85	Bola protein
IM45_615	ENOG4105E2S	oxidase) subunit II
IM45_617	ENOG4105BZ9	Cytochrome C oxidase, subunit I
IM45_619	ENOG4105CCU	oxidase (Subunit III)
IM45_620	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
IM45_621	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
IM45_625	ENOG4107RDB	Major Facilitator
IM45_627	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
IM45_631	ENOG4105CTB	Polyprenyl synthetase
IM45_633	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
IM45_635	ENOG4105C75	arginyL-tRNA synthetase
IM45_637	ENOG4105CJR	Integral membrane protein (MviN
IM45_639	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
IM45_640	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
IM45_644	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
IM45_647	ENOG4105C3F	Signal peptidase i
IM45_648	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
IM45_654	ENOG4105MYG	DNA polymerase iii, chi subunit
IM45_656	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
IM45_658	ENOG4108M8S	permease YjgP YjgQ family protein
IM45_661	ENOG4108K5H	permease YjgP YjgQ family protein
IM45_662	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
IM45_664	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
IM45_665	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
IM45_668	ENOG4105C1U	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)
IM45_669	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
IM45_672	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
IM45_674	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
IM45_676	ENOG4105C3G	gtp-binding protein
IM45_678	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
IM45_680	ENOG4108ENQ	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
IM45_682	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
IM45_686	ENOG4105Q4A	inner membrane protein yciS
IM45_690	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
IM45_692	ENOG4107R11	Transcriptional regulator
IM45_694	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
IM45_696	ENOG4108S3I	UPF0259 membrane protein
IM45_698	ENOG4105K9H	YciI-like protein
IM45_700	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
IM45_704	ENOG4105D0M	Protease HtpX homolog
IM45_706	ENOG41073DY	may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)
IM45_708	ENOG41090A1	ferritin
IM45_710	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
IM45_712	ENOG4105CA9	Pyruvate kinase
IM45_714	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
IM45_716	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
IM45_718	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
IM45_720	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
IM45_722	ENOG4105CDY	transcriptional regulatory protein
IM45_724	ENOG4105C9M	aspartyl-trna synthetase
IM45_726	ENOG4107SSZ	Phosphatase
IM45_729	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
IM45_731	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
IM45_733	ENOG4105CNU	cell division protein FtsK
IM45_733	ENOG4105CNU	cell division protein FtsK
IM45_735	ENOG4105C3M	thioredoxin reductase
IM45_737	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
IM45_739	ENOG4105E5Z	arginine transporter ATP-binding subunit
IM45_741	ENOG4106PMH	Extracellular solute-binding protein family 3
IM45_742	ENOG4105GBT	ABC transporter
IM45_743	ENOG4105DMR	ABC, transporter
IM45_747	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
IM45_749	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
IM45_751	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
IM45_752	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
IM45_755	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IM45_757	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
IM45_759	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
IM45_761	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
IM45_763	ENOG41083MP	50s ribosomal protein l29
IM45_765	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
IM45_767	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
IM45_769	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
IM45_771	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
IM45_773	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IM45_775	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
IM45_777	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
IM45_779	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
IM45_781	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
IM45_783	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
IM45_785	ENOG4105VPB	50S ribosomal protein L30
IM45_787	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
IM45_789	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
IM45_791	ENOG41067V7	50S ribosomal protein L36
IM45_793	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IM45_795	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
IM45_797	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
IM45_801	ENOG4108ZT0	50S ribosomal protein l17
IM45_807	ENOG4105CS9	pantothenic acid kinase
IM45_809	ENOG4108BY2	phosphohistidine phosphatase
IM45_811	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
IM45_813	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
IM45_815	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
IM45_817	ENOG4105CJ0	Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity)
IM45_819	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
IM45_821	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
IM45_823	ENOG4108S3P	Sporulation domain protein
IM45_825	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
IM45_827	ENOG4105E96	Colicin v production protein
IM45_829	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
IM45_831	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
IM45_833	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM45_835	ENOG4105C8S	subunit m
IM45_837	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM45_839	ENOG4105D65	subunit l
IM45_841	ENOG4107UFS	subunit j
IM45_843	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM45_844	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
IM45_845	ENOG4107R0R	NADH dehydrogenase subunit g
IM45_849	ENOG4105GKE	subunit e
IM45_851	ENOG4107QIZ	NADH dehydrogenase
IM45_853	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM45_855	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM45_857	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IM45_859	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
IM45_861	ENOG4105C6K	Malic enzyme
IM45_863	ENOG4105XPH	Ferredoxin
IM45_865	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
IM45_867	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
IM45_869	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
IM45_871	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IM45_873	ENOG4105CPF	Cell wall formation (By similarity)
IM45_876	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
IM45_878	ENOG4107TT5	NLP P60 protein
IM45_880	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
IM45_882	ENOG4108IQI	permease
IM45_884	ENOG4105EUJ	GTP cyclohydrolase i
IM45_886	ENOG4105DHP	deoxycytidine triphosphate deaminase
IM45_888	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
IM45_890	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
IM45_892	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
IM45_893	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
IM45_894	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
IM45_898	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
IM45_899	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
IM45_902	ENOG4105CIH	Imidazole acetol-phosphate transaminase
IM45_903	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
IM45_906	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
IM45_908	ENOG4108535	NAD dependent epimerase/dehydratase family
IM45_910	ENOG4105C5X	domain protein
IM45_912	ENOG4105CGF	Aromatic amino acid aminotransferase
IM45_914	ENOG4105C5S	asparaginyl-tRNA synthetase
IM45_916	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
IM45_918	ENOG4108RKI	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity)
IM45_920	ENOG4105DAN	ATP-dependent protease
IM45_922	ENOG4105GSS	Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity)
IM45_924	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
IM45_927	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
IM45_929	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
IM45_931	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
IM45_933	ENOG4105E2X	shikimate dehydrogenase
IM45_935	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
IM45_937	ENOG4105C9Q	fumarate hydratase class II
IM45_939	ENOG4105D52	delta-aminolevulinic acid dehydratase
IM45_942	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
IM45_944	ENOG41075W9	High frequency lysogenization protein HflD homolog
IM45_946	ENOG4107QTF	adenylosuccinate lyase
IM45_948	ENOG4105D60	lipoprotein releasing system transmembrane protein
IM45_950	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
IM45_951	ENOG4105D60	lipoprotein releasing system transmembrane protein
IM45_954	ENOG4108WEF	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity)
IM45_956	ENOG4105K59	histidine triad (HIT) protein
IM45_958	ENOG4105F8V	Hydrolase, tatD family
IM45_960	ENOG4107QRG	dna polymerase iii
IM45_961	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
IM45_964	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
IM45_966	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
IM45_968	ENOG4105CHR	reductase
IM45_969	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
IM45_972	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
IM45_974	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
IM45_976	ENOG4105VGS	50s ribosomal protein l32
IM45_978	ENOG4105EI2	Pseudouridine synthase
IM45_980	ENOG4107QQB	Ribonuclease E
IM45_984	ENOG4105D07	Signal peptide peptidase, SppA
IM45_986	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
IM45_988	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
IM45_990	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
IM45_992	ENOG4107QMS	site-determining protein
IM45_994	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
IM45_996	ENOG41072GX	Peptidase M22 Glycoprotease
IM45_998	ENOG4105F3R	pts system mannose fructose sorbose family iid