locus-tag	class	description
IM45_003	COG0590	tRNA wobble adenosine to inosine editing
IM45_005	COG0047	phosphoribosylformylglycinamidine synthase activity
IM45_005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IM45_007	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IM45_009	COG0483	inositol monophosphate 1-phosphatase activity
IM45_013	COG0105	UTP biosynthetic process
IM45_015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IM45_017	COG0124	histidyl-tRNA synthetase
IM45_019	COG1160	GTP binding
IM45_021	COG0166	Belongs to the GPI family
IM45_023	COG1918	ferrous iron import across plasma membrane
IM45_025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IM45_031	COG0494	nUDIX hydrolase
IM45_033	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IM45_035	COG0583	DNA-binding transcription factor activity
IM45_037	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IM45_039	COG1322	Protein conserved in bacteria
IM45_045	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IM45_047	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IM45_049	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IM45_051	COG2937	Belongs to the GPAT DAPAT family
IM45_053	COG0180	Tryptophanyl-tRNA synthetase
IM45_055	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IM45_061	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IM45_063	COG0586	Pfam SNARE associated Golgi protein
IM45_067	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IM45_068	COG2823	Periplasmic or secreted lipoprotein
IM45_071	COG5007	Belongs to the BolA IbaG family
IM45_073	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IM45_075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM45_077	COG3105	Protein conserved in bacteria
IM45_079	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IM45_085	COG3117	lipopolysaccharide transmembrane transporter activity
IM45_086	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IM45_089	COG1137	ATPase activity
IM45_095	COG0138	bifunctional purine biosynthesis protein purh
IM45_097	COG0151	Belongs to the GarS family
IM45_1000	COG3715	PTS system
IM45_1002	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IM45_1002	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IM45_1004	COG1253	flavin adenine dinucleotide binding
IM45_1015	COG2814	Major facilitator Superfamily
IM45_1017	COG1566	PFAM secretion protein HlyD family protein
IM45_1019	COG2166	iron-sulfur cluster assembly
IM45_1021	COG0719	Fe-S assembly protein
IM45_1022	COG0396	ATPase activity
IM45_1025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IM45_1027	COG0316	Belongs to the HesB IscA family
IM45_1029	COG0719	Fe-S assembly protein
IM45_1033	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IM45_1033	COG0072	phenylalanine-tRNA ligase activity
IM45_1035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IM45_104	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IM45_1041	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IM45_1045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IM45_1049	COG2226	methyltransferase
IM45_1055	COG0741	lytic transglycosylase activity
IM45_1057	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IM45_1059	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IM45_1061	COG0762	integral membrane protein
IM45_1063	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IM45_1064	COG1678	Uncharacterized ACR, COG1678
IM45_1067	COG0189	ligase activity
IM45_1069	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IM45_107	COG2104	thiamine diphosphate biosynthetic process
IM45_1071	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IM45_1071	COG0316	Belongs to the HesB IscA family
IM45_1077	COG0735	belongs to the Fur family
IM45_1079	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
IM45_1081	COG2923	Belongs to the DsrF TusC family
IM45_1083	COG2168	tRNA wobble position uridine thiolation
IM45_1087	COG0049	tRNA binding
IM45_1089	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IM45_1093	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM45_1094	COG0250	Participates in transcription elongation, termination and antitermination
IM45_1099	COG0081	regulation of translation
IM45_110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IM45_1105	COG0085	RNA polymerase activity
IM45_1107	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IM45_1109	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IM45_1117	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IM45_1119	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM45_1121	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IM45_1123	COG0157	Belongs to the NadC ModD family
IM45_1125	COG0237	dephospho-CoA kinase activity
IM45_1127	COG0653	protein targeting
IM45_113	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IM45_1131	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IM45_1135	COG0849	cell division
IM45_1137	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IM45_1139	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IM45_1141	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM45_1142	COG0772	Belongs to the SEDS family
IM45_1147	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM45_1148	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IM45_1149	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IM45_115	COG1792	Involved in formation and maintenance of cell shape
IM45_1153	COG0768	penicillin binding
IM45_1155	COG3116	cell division
IM45_1161	COG0024	Methionine aminopeptidase
IM45_1165	COG0052	Belongs to the universal ribosomal protein uS2 family
IM45_1167	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IM45_1169	COG0528	UMP kinase activity
IM45_117	COG1077	Cell shape determining protein MreB Mrl
IM45_1171	COG0233	cytoplasmic translational termination
IM45_1175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IM45_1177	COG0575	Belongs to the CDS family
IM45_1179	COG0750	zinc metalloprotease
IM45_1180	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM45_1183	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
IM45_1185	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IM45_1187	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IM45_1189	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IM45_119	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IM45_1191	COG0587	DNA-directed DNA polymerase activity
IM45_1195	COG0626	cystathionine gamma-synthase activity
IM45_1197	COG3066	DNA modification
IM45_1199	COG1051	belongs to the nudix hydrolase family
IM45_1201	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IM45_1205	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
IM45_1207	COG1074	ATP-dependent DNA helicase activity
IM45_1209	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IM45_121	COG0511	ligase activity, forming carbon-carbon bonds
IM45_1215	COG0305	Participates in initiation and elongation during chromosome replication
IM45_1217	COG0443	Heat shock 70 kDa protein
IM45_1219	COG0484	heat shock protein binding
IM45_1221	COG0268	Binds directly to 16S ribosomal RNA
IM45_1223	COG0196	riboflavin kinase activity
IM45_1225	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IM45_1229	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IM45_123	COG0439	Biotin carboxylase
IM45_1235	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IM45_1239	COG2967	ApaG domain
IM45_1242	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IM45_1245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IM45_1250	COG2914	Belongs to the UPF0125 (RnfH) family
IM45_1251	COG2867	negative regulation of translational initiation
IM45_1254	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IM45_1263	COG2965	DNA replication, synthesis of RNA primer
IM45_1267	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM45_1269	COG0557	exoribonuclease II activity
IM45_1273	COG0330	HflC and HflK could
IM45_1275	COG0330	HflC and HflK could
IM45_1277	COG1923	regulation of RNA biosynthetic process
IM45_1283	COG0802	atpase or kinase
IM45_1287	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IM45_1289	COG0688	phosphatidylethanolamine metabolic process
IM45_1291	COG1511	domain protein
IM45_1291	COG3264	Mechanosensitive ion channel
IM45_1293	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IM45_1304	COG0450	alkyl hydroperoxide reductase
IM45_131	COG0306	phosphate transporter
IM45_1310	COG1862	Preprotein translocase
IM45_1312	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IM45_1314	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IM45_1316	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IM45_1318	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM45_1318	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM45_1324	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IM45_1325	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IM45_1328	COG0729	surface antigen
IM45_1332	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IM45_1335	COG0442	prolyl-tRNA aminoacylation
IM45_1338	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IM45_1340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IM45_1342	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IM45_1344	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IM45_1347	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IM45_1349	COG0358	DNA primase activity
IM45_135	COG0425	Belongs to the sulfur carrier protein TusA family
IM45_1355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IM45_1357	COG1968	undecaprenyl-diphosphatase activity
IM45_1361	COG2960	long-chain fatty acid transporting porin activity
IM45_1365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IM45_1367	COG0204	Acyl-transferase
IM45_1369	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IM45_137	COG0552	protein localization to endoplasmic reticulum
IM45_1371	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
IM45_1373	COG0513	Belongs to the DEAD box helicase family
IM45_1377	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IM45_1381	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IM45_1383	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IM45_1385	COG0195	Participates in both transcription termination and antitermination
IM45_1389	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM45_139	COG2884	Cell division ATP-binding protein ftsE
IM45_1391	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IM45_1393	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IM45_1395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IM45_1397	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IM45_140	COG2177	Part of the ABC transporter FtsEX involved in
IM45_1401	COG2027	D-alanyl-D-alanine carboxypeptidase
IM45_1403	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IM45_1409	COG0142	geranyltranstransferase activity
IM45_1411	COG0126	phosphoglycerate kinase activity
IM45_1417	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IM45_1419	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IM45_1421	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM45_1423	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM45_1425	COG0351	phosphomethylpyrimidine kinase
IM45_1427	COG0519	Catalyzes the synthesis of GMP from XMP
IM45_1427	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IM45_1429	COG0517	IMP dehydrogenase activity
IM45_1429	COG0516	GMP reductase activity
IM45_145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IM45_153	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IM45_155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IM45_159	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM45_161	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IM45_163	COG3115	cell septum assembly
IM45_167	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IM45_169	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IM45_173	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM45_175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IM45_177	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IM45_179	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IM45_181	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IM45_183	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IM45_185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IM45_187	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IM45_189	COG4208	sulfate ABC transporter
IM45_195	COG2878	Part of a membrane complex involved in electron transport
IM45_197	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IM45_201	COG1846	Transcriptional regulator
IM45_207	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IM45_209	COG0307	riboflavin synthase, alpha
IM45_216	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IM45_220	COG0033	Phosphoglucomutase
IM45_224	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IM45_228	COG0811	peptide transport
IM45_230	COG0848	biopolymer transport protein
IM45_232	COG3064	Membrane
IM45_234	COG0823	Involved in the tonB-independent uptake of proteins
IM45_236	COG2885	chlorophyll binding
IM45_238	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
IM45_240	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IM45_242	COG0037	tRNA processing
IM45_244	COG0025	NhaP-type Na H and K H
IM45_248	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IM45_252	COG0629	single-stranded DNA binding
IM45_256	COG1301	dicarboxylic acid transport
IM45_258	COG1846	Transcriptional regulator
IM45_260	COG0194	GDP metabolic process
IM45_262	COG1758	RNA polymerase activity
IM45_264	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IM45_266	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IM45_268	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IM45_270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IM45_270	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IM45_274	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IM45_278	COG0563	adenylate kinase activity
IM45_280	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IM45_282	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IM45_284	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IM45_291	COG2199	diguanylate cyclase activity
IM45_291	COG2200	EAL domain
IM45_295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IM45_297	COG1011	Hydrolase
IM45_299	COG0210	DNA helicase
IM45_301	COG0598	Magnesium transport protein CorA
IM45_305	COG0187	DNA topoisomerase II activity
IM45_307	COG0592	DNA-directed DNA polymerase activity
IM45_309	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IM45_315	COG0594	ribonuclease P activity
IM45_319	COG0706	membrane insertase activity
IM45_320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IM45_323	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IM45_327	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IM45_329	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IM45_331	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IM45_333	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IM45_335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IM45_341	COG0356	it plays a direct role in the translocation of protons across the membrane
IM45_345	COG0354	folic acid binding
IM45_347	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IM45_349	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IM45_351	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IM45_353	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IM45_361	COG0751	glycine-tRNA ligase activity
IM45_363	COG0752	glycyl-tRNA synthetase alpha subunit
IM45_365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IM45_370	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
IM45_374	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IM45_376	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IM45_381	COG0149	triose-phosphate isomerase activity
IM45_383	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IM45_385	COG0205	6-phosphofructokinase activity
IM45_387	COG1045	serine acetyltransferase
IM45_389	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IM45_391	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IM45_393	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM45_395	COG4942	peptidase
IM45_397	COG2861	carbohydrate metabolic process
IM45_399	COG1519	Transferase
IM45_401	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IM45_403	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IM45_407	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IM45_409	COG1561	YicC-like family, N-terminal region
IM45_411	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IM45_413	COG0756	dUTP diphosphatase activity
IM45_414	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IM45_421	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IM45_427	COG2244	polysaccharide biosynthetic process
IM45_429	COG0456	acetyltransferase
IM45_430	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IM45_431	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IM45_433	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IM45_434	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IM45_441	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM45_443	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IM45_445	COG3118	belongs to the thioredoxin family
IM45_447	COG3085	chromosome segregation
IM45_449	COG0583	DNA-binding transcription factor activity
IM45_451	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IM45_453	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM45_455	COG0564	pseudouridine synthase activity
IM45_457	COG0542	response to heat
IM45_461	COG0336	Belongs to the RNA methyltransferase TrmD family
IM45_467	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IM45_473	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IM45_479	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM45_481	COG0765	amino acid transport
IM45_485	COG4942	peptidase
IM45_485	COG1388	LysM domain
IM45_487	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IM45_489	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IM45_493	COG0529	Catalyzes the synthesis of activated sulfate
IM45_494	COG2895	sulfate adenylyltransferase (ATP) activity
IM45_498	COG0175	sulfate reduction
IM45_507	COG0720	synthase
IM45_509	COG0602	queuosine metabolic process
IM45_511	COG0148	phosphopyruvate hydratase activity
IM45_513	COG0504	CTP synthase activity
IM45_515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IM45_517	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IM45_519	COG0316	Belongs to the HesB IscA family
IM45_521	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM45_523	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IM45_525	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IM45_527	COG0617	tRNA 3'-terminal CCA addition
IM45_533	COG0495	leucyl-tRNA aminoacylation
IM45_535	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
IM45_536	COG1466	dna polymerase III delta subunit
IM45_541	COG0768	penicillin binding
IM45_542	COG0772	Belongs to the SEDS family
IM45_545	COG0321	lipoyl(octanoyl) transferase activity
IM45_547	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IM45_549	COG0477	Major facilitator Superfamily
IM45_551	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IM45_556	COG2706	6-phosphogluconolactonase activity
IM45_558	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IM45_560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IM45_561	COG0156	8-amino-7-oxononanoate synthase activity
IM45_562	COG2226	methyltransferase
IM45_568	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IM45_572	COG0588	phosphoglycerate mutase activity
IM45_574	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IM45_578	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IM45_580	COG0539	negative regulation of cytoplasmic translation
IM45_582	COG0776	regulation of translation
IM45_586	COG1132	(ABC) transporter
IM45_589	COG2835	tetraacyldisaccharide 4'-kinase activity
IM45_601	COG1278	Cold shock
IM45_605	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IM45_607	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IM45_611	COG0544	peptidyl-prolyl cis-trans isomerase activity
IM45_613	COG0271	Belongs to the BolA IbaG family
IM45_615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IM45_617	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM45_619	COG1845	cytochrome c oxidase, subunit III
IM45_620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IM45_621	COG0109	protoheme IX farnesyltransferase activity
IM45_625	COG2814	Major facilitator Superfamily
IM45_631	COG0142	geranyltranstransferase activity
IM45_633	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IM45_640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IM45_644	COG0571	ribonuclease III activity
IM45_647	COG0681	Belongs to the peptidase S26 family
IM45_648	COG0481	GTPase activity
IM45_654	COG2927	DNA polymerase III (CHI subunit)
IM45_656	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IM45_658	COG0795	lipopolysaccharide-transporting ATPase activity
IM45_661	COG0795	lipopolysaccharide-transporting ATPase activity
IM45_662	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IM45_664	COG2890	protein-(glutamine-N5) methyltransferase activity
IM45_668	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IM45_676	COG0012	GTP binding
IM45_686	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
IM45_692	COG0583	DNA-binding transcription factor activity
IM45_694	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IM45_698	COG2350	Protein conserved in bacteria
IM45_700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IM45_704	COG0501	Belongs to the peptidase M48B family
IM45_706	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
IM45_708	COG1528	Iron-storage protein
IM45_710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IM45_712	COG0469	pyruvate kinase activity
IM45_714	COG1914	H( )-stimulated, divalent metal cation uptake system
IM45_722	COG0217	transcriptional regulatory protein
IM45_724	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IM45_731	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IM45_733	COG1674	ftsk spoiiie
IM45_733	COG1674	ftsk spoiiie
IM45_733	COG3107	peptidoglycan biosynthetic process
IM45_733	COG3107	peptidoglycan biosynthetic process
IM45_735	COG0492	ferredoxin-NADP+ reductase activity
IM45_737	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IM45_739	COG1126	abc transporter atp-binding protein
IM45_741	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM45_742	COG4215	(ABC) transporter
IM45_743	COG4160	amino acid transport
IM45_749	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IM45_751	COG0088	Forms part of the polypeptide exit tunnel
IM45_752	COG0089	rRNA binding
IM45_759	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IM45_761	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IM45_769	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IM45_771	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IM45_775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IM45_779	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IM45_781	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IM45_783	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IM45_785	COG1841	ribosomal large subunit assembly
IM45_787	COG0200	Binds to the 23S rRNA
IM45_789	COG0201	protein transport
IM45_793	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IM45_797	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IM45_801	COG0203	ribosomal protein L17
IM45_807	COG1072	(Pantothenic acid kinase))
IM45_809	COG2062	phosphohistidine phosphatase, SixA
IM45_811	COG2890	protein-(glutamine-N5) methyltransferase activity
IM45_815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IM45_819	COG0101	tRNA pseudouridine synthase activity
IM45_823	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
IM45_825	COG0285	dihydrofolate synthase activity
IM45_827	COG1286	toxin biosynthetic process
IM45_829	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IM45_831	COG0163	prenyltransferase activity
IM45_833	COG1007	ATP synthesis coupled electron transport
IM45_835	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM45_837	COG0713	ATP synthesis coupled electron transport
IM45_839	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IM45_841	COG0839	Belongs to the complex I subunit 6 family
IM45_843	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM45_844	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IM45_845	COG1034	ATP synthesis coupled electron transport
IM45_849	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IM45_855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM45_857	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM45_861	COG0280	phosphate acetyltransferase
IM45_861	COG0857	belongs to the CobB CobQ family
IM45_863	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IM45_865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM45_867	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM45_869	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IM45_876	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IM45_878	COG0791	NLP P60 protein
IM45_880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IM45_882	COG0833	amino acid
IM45_886	COG0717	Belongs to the dCTP deaminase family
IM45_892	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IM45_892	COG0140	phosphoribosyl-ATP diphosphatase activity
IM45_898	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IM45_903	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IM45_908	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IM45_910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM45_912	COG1448	Aminotransferase
IM45_914	COG0017	Asparaginyl-tRNA synthetase
IM45_920	COG1067	ATP-dependent peptidase activity
IM45_924	COG2920	part of a sulfur-relay system
IM45_933	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IM45_935	COG0674	pyruvate-flavodoxin oxidoreductase activity
IM45_935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM45_935	COG1013	pyruvate-flavodoxin oxidoreductase activity
IM45_935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IM45_937	COG0114	fumarate hydratase activity
IM45_939	COG0113	porphobilinogen synthase activity
IM45_942	COG0482	sulfurtransferase activity
IM45_944	COG2915	High frequency lysogenization protein hflD homolog
IM45_946	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IM45_948	COG4591	ABC-type transport system involved in lipoprotein release permease component
IM45_950	COG1136	(ABC) transporter
IM45_951	COG4591	ABC-type transport system involved in lipoprotein release permease component
IM45_954	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
IM45_956	COG0537	adenosine 5'-monophosphoramidase activity
IM45_958	COG0084	hydrolase, TatD family'
IM45_960	COG0470	DNA polymerase III
IM45_961	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IM45_964	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IM45_966	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IM45_968	COG1028	Short-chain dehydrogenase reductase Sdr
IM45_974	COG0416	fatty acid biosynthetic process
IM45_976	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IM45_978	COG0564	pseudouridine synthase activity
IM45_980	COG1530	ribonuclease E activity
IM45_984	COG0616	signal peptide processing
IM45_986	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IM45_988	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IM45_992	COG2894	cell division
IM45_998	COG3716	PTS system mannose fructose sorbose family IID component