locus-tag	class	description
IPG59_00080	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IPG59_00105	COG3344	reverse transcriptase
IPG59_00130	COG0545	Peptidyl-prolyl cis-trans isomerase
IPG59_00135	COG0484	heat shock protein binding
IPG59_00145	COG0081	regulation of translation
IPG59_00150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPG59_00155	COG0250	Participates in transcription elongation, termination and antitermination
IPG59_00180	COG0601	transmembrane transport
IPG59_00185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPG59_00200	COG0745	RESPONSE REGULATOR receiver
IPG59_00215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPG59_00225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPG59_00240	COG0511	ligase activity, forming carbon-carbon bonds
IPG59_00245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPG59_00250	COG1024	Enoyl-CoA hydratase
IPG59_00255	COG0746	molybdenum cofactor guanylyltransferase activity
IPG59_00275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IPG59_00285	COG1131	(ABC) transporter
IPG59_00295	COG1459	type II secretion system
IPG59_00305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPG59_00345	COG0745	RESPONSE REGULATOR receiver
IPG59_00355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IPG59_00370	COG1254	Belongs to the acylphosphatase family
IPG59_00375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPG59_00385	COG2197	response regulator
IPG59_00390	COG4585	Histidine kinase
IPG59_00400	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPG59_00400	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPG59_00405	COG1524	type I phosphodiesterase nucleotide pyrophosphatase
IPG59_00420	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPG59_00425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPG59_00445	COG1592	Rubrerythrin
IPG59_00450	COG0735	belongs to the Fur family
IPG59_00525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPG59_00530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPG59_00535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPG59_00540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPG59_00545	COG0531	amino acid
IPG59_00550	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPG59_00555	COG0628	permease
IPG59_00560	COG0530	calcium, potassium:sodium antiporter activity
IPG59_00565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPG59_00570	COG0504	CTP synthase activity
IPG59_00585	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IPG59_00620	COG0758	DNA mediated transformation
IPG59_00620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPG59_00645	COG0318	PFAM AMP-dependent synthetase and ligase
IPG59_00670	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPG59_00695	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IPG59_00710	COG1253	flavin adenine dinucleotide binding
IPG59_00715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPG59_00720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPG59_00725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPG59_00755	COG0784	Response regulator, receiver
IPG59_00755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPG59_00755	COG2198	Histidine kinase
IPG59_00755	COG2205	protein histidine kinase activity
IPG59_00765	COG0750	zinc metalloprotease
IPG59_00770	COG2385	sporulation resulting in formation of a cellular spore
IPG59_00775	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPG59_00780	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPG59_00785	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPG59_00795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPG59_00800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPG59_00805	COG0356	it plays a direct role in the translocation of protons across the membrane
IPG59_00815	COG1842	Phage shock protein A
IPG59_00830	COG1196	nuclear chromosome segregation
IPG59_00850	COG1799	cell septum assembly
IPG59_00855	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPG59_00860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPG59_00865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IPG59_00875	COG0756	dUTP diphosphatase activity
IPG59_00890	COG0582	viral genome integration into host DNA
IPG59_00955	COG4453	Protein conserved in bacteria
IPG59_00980	COG1252	NADH dehydrogenase
IPG59_00985	COG0739	heme binding
IPG59_01000	COG2815	serine threonine protein kinase
IPG59_01000	COG0515	serine threonine protein kinase
IPG59_01010	COG1073	alpha beta
IPG59_01055	COG1846	Transcriptional regulator
IPG59_01065	COG1196	nuclear chromosome segregation
IPG59_01065	COG3264	Mechanosensitive ion channel
IPG59_01070	COG1247	-acetyltransferase
IPG59_01115	COG4251	negative regulation of phosphorylation
IPG59_01120	COG0784	Response regulator, receiver
IPG59_01130	COG1408	metallophosphoesterase
IPG59_01150	COG0222	ribosome binding
IPG59_01185	COG0598	Magnesium transport protein CorA
IPG59_01205	COG1132	(ABC) transporter
IPG59_01215	COG0488	(ABC) transporter
IPG59_01220	COG0488	(ABC) transporter
IPG59_01230	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPG59_01245	COG1063	alcohol dehydrogenase
IPG59_01285	COG0783	Belongs to the Dps family
IPG59_01290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IPG59_01300	COG0076	glutamate decarboxylase activity
IPG59_01385	COG1361	Conserved repeat domain
IPG59_01390	COG1953	Uracil, thiamine, allantoin
IPG59_01395	COG0596	Alpha beta hydrolase
IPG59_01425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IPG59_01470	COG0659	secondary active sulfate transmembrane transporter activity
IPG59_01495	COG3118	belongs to the thioredoxin family
IPG59_01515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPG59_01545	COG2326	polyphosphate kinase activity
IPG59_01625	COG3550	peptidyl-serine autophosphorylation
IPG59_01665	COG3541	Predicted nucleotidyltransferase
IPG59_01710	COG1569	PIN domain
IPG59_01750	COG3541	Predicted nucleotidyltransferase
IPG59_01790	COG2801	Transposase and inactivated derivatives
IPG59_01830	COG1538	Outer membrane efflux protein
IPG59_01840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPG59_01935	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPG59_01945	COG0444	Belongs to the ABC transporter superfamily
IPG59_01950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPG59_01950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IPG59_01955	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPG59_01960	COG1619	proteins homologs of microcin C7 resistance protein MccF
IPG59_01975	COG0142	geranyltranstransferase activity
IPG59_02015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPG59_02035	COG0736	holo-[acyl-carrier-protein] synthase activity
IPG59_02060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPG59_02070	COG1472	Belongs to the glycosyl hydrolase 3 family
IPG59_02075	COG0515	serine threonine protein kinase
IPG59_02075	COG2815	serine threonine protein kinase
IPG59_02100	COG0009	L-threonylcarbamoyladenylate synthase
IPG59_02105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPG59_02115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPG59_02115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IPG59_02120	COG0205	6-phosphofructokinase activity
IPG59_02125	COG0045	succinate-CoA ligase (ADP-forming) activity
IPG59_02130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IPG59_02155	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPG59_02165	COG0436	Aminotransferase
IPG59_02230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPG59_02240	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
IPG59_02250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IPG59_02280	COG2197	response regulator
IPG59_02285	COG0698	ribose 5-phosphate isomerase
IPG59_02300	COG1929	Belongs to the glycerate kinase type-1 family
IPG59_02305	COG1652	LysM domain
IPG59_02330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPG59_02345	COG2815	serine threonine protein kinase
IPG59_02345	COG0515	serine threonine protein kinase
IPG59_02355	COG0745	RESPONSE REGULATOR receiver
IPG59_02365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IPG59_02445	COG0561	phosphatase activity
IPG59_02450	COG5002	protein histidine kinase activity
IPG59_02450	COG2205	protein histidine kinase activity
IPG59_02450	COG0784	Response regulator, receiver
IPG59_02455	COG0784	Response regulator, receiver
IPG59_02455	COG2198	Histidine kinase
IPG59_02455	COG2205	protein histidine kinase activity
IPG59_02495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPG59_02500	COG1733	regulation of RNA biosynthetic process
IPG59_02515	COG1335	isochorismatase
IPG59_02555	COG2197	response regulator
IPG59_02570	COG2815	serine threonine protein kinase
IPG59_02570	COG0515	serine threonine protein kinase
IPG59_02580	COG1309	transcriptional regulator
IPG59_02645	COG1309	transcriptional regulator
IPG59_02675	COG3878	Protein conserved in bacteria
IPG59_02690	COG0464	growth
IPG59_02705	COG3437	response regulator, receiver
IPG59_02705	COG4999	Histidine kinase
IPG59_02705	COG2205	protein histidine kinase activity
IPG59_02705	COG3850	Histidine kinase
IPG59_02720	COG3420	alginic acid biosynthetic process
IPG59_02730	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IPG59_02810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPG59_02815	COG0483	inositol monophosphate 1-phosphatase activity
IPG59_02820	COG0418	dihydroorotase activity
IPG59_02825	COG0167	dihydroorotate dehydrogenase activity
IPG59_02840	COG1193	negative regulation of DNA recombination
IPG59_02860	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPG59_02865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPG59_02890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPG59_02895	COG2815	serine threonine protein kinase
IPG59_02895	COG0515	serine threonine protein kinase
IPG59_02920	COG3093	addiction module antidote protein HigA
IPG59_02925	COG0308	aminopeptidase N
IPG59_02930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPG59_02930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPG59_02940	COG2201	protein-glutamate methylesterase activity
IPG59_02945	COG2205	protein histidine kinase activity
IPG59_02945	COG0784	Response regulator, receiver
IPG59_02945	COG5002	protein histidine kinase activity
IPG59_02965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPG59_02980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPG59_03010	COG0515	serine threonine protein kinase
IPG59_03010	COG2815	serine threonine protein kinase
IPG59_03050	COG0538	isocitrate dehydrogenase activity
IPG59_03055	COG0318	PFAM AMP-dependent synthetase and ligase
IPG59_03085	COG1215	transferase activity, transferring glycosyl groups
IPG59_03095	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPG59_03100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPG59_03110	COG3483	tryptophan 2,3-dioxygenase activity
IPG59_03155	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IPG59_03160	COG1960	acyl-CoA dehydrogenase activity
IPG59_03190	COG2197	response regulator
IPG59_03200	COG0708	Exodeoxyribonuclease III
IPG59_03225	COG0667	Aldo Keto reductase
IPG59_03250	COG1073	alpha beta
IPG59_03260	COG1053	succinate dehydrogenase
IPG59_03295	COG0018	arginyl-trna synthetase
IPG59_03305	COG0515	serine threonine protein kinase
IPG59_03310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPG59_03315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPG59_03335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IPG59_03360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPG59_03365	COG2154	pterin-4-alpha-carbinolamine dehydratase
IPG59_03390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPG59_03405	COG2027	D-alanyl-D-alanine carboxypeptidase
IPG59_03420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPG59_03430	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPG59_03445	COG0681	Belongs to the peptidase S26 family
IPG59_03450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPG59_03455	COG0193	aminoacyl-tRNA hydrolase activity
IPG59_03490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPG59_03515	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IPG59_03525	COG0392	lysyltransferase activity
IPG59_03525	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IPG59_03570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPG59_03580	COG0612	Peptidase, M16
IPG59_03595	COG2801	Transposase and inactivated derivatives
IPG59_03615	COG0222	ribosome binding
IPG59_03620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPG59_03645	COG0751	glycine-tRNA ligase activity
IPG59_03670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPG59_03670	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPG59_03680	COG0402	S-adenosylhomocysteine deaminase activity
IPG59_03685	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IPG59_03695	COG0612	Peptidase, M16
IPG59_03700	COG0612	Peptidase, M16
IPG59_03710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPG59_03715	COG0793	Belongs to the peptidase S41A family
IPG59_03730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPG59_03745	COG0513	Belongs to the DEAD box helicase family
IPG59_03760	COG0793	Belongs to the peptidase S41A family
IPG59_03765	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IPG59_03775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPG59_03800	COG0156	8-amino-7-oxononanoate synthase activity
IPG59_03805	COG1045	serine acetyltransferase
IPG59_03825	COG1960	acyl-CoA dehydrogenase activity
IPG59_03830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPG59_03850	COG0534	Mate efflux family protein
IPG59_03855	COG2003	Belongs to the UPF0758 family
IPG59_03860	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPG59_03870	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IPG59_03875	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IPG59_03880	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IPG59_03885	COG2205	protein histidine kinase activity
IPG59_03890	COG0745	RESPONSE REGULATOR receiver
IPG59_03940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPG59_03945	COG2086	electron transfer activity
IPG59_03965	COG5002	protein histidine kinase activity
IPG59_03970	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPG59_03985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPG59_03990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPG59_04005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPG59_04015	COG0247	lactate metabolic process
IPG59_04020	COG0277	FAD linked oxidase domain protein
IPG59_04030	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IPG59_04035	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IPG59_04040	COG5002	protein histidine kinase activity
IPG59_04050	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IPG59_04060	COG4964	Belongs to the GSP D family
IPG59_04065	COG4964	Belongs to the GSP D family
IPG59_04075	COG0745	RESPONSE REGULATOR receiver
IPG59_04080	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPG59_04090	COG0148	phosphopyruvate hydratase activity
IPG59_04110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPG59_04135	COG0575	Belongs to the CDS family
IPG59_04145	COG2255	four-way junction helicase activity
IPG59_04150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPG59_04170	COG0742	ribosomal rna small subunit methyltransferase
IPG59_04175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPG59_04180	COG0552	protein localization to endoplasmic reticulum
IPG59_04185	COG3253	May function as heme-dependent peroxidase
IPG59_04195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPG59_04200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IPG59_04205	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IPG59_04210	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPG59_04215	COG0792	nuclease activity
IPG59_04225	COG0019	diaminopimelate decarboxylase activity
IPG59_04230	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IPG59_04235	COG0284	orotidine-5'-phosphate decarboxylase activity
IPG59_04240	COG0254	rRNA binding
IPG59_04265	COG0085	RNA polymerase activity
IPG59_04320	COG0285	dihydrofolate synthase activity
IPG59_04325	COG0494	nUDIX hydrolase
IPG59_04345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPG59_04350	COG0305	Participates in initiation and elongation during chromosome replication
IPG59_04365	COG0484	heat shock protein binding
IPG59_04370	COG0443	Heat shock 70 kDa protein
IPG59_04375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPG59_04385	COG4948	Mandelate Racemase Muconate Lactonizing
IPG59_04410	COG0574	Belongs to the PEP-utilizing enzyme family
IPG59_04410	COG3848	Pyruvate phosphate dikinase
IPG59_04435	COG0318	PFAM AMP-dependent synthetase and ligase
IPG59_04445	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IPG59_04450	COG2815	serine threonine protein kinase
IPG59_04450	COG0515	serine threonine protein kinase
IPG59_04475	COG0366	Alpha amylase catalytic
IPG59_04500	COG2814	Major facilitator Superfamily
IPG59_04630	COG2267	carboxylic ester hydrolase activity
IPG59_04650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPG59_04665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IPG59_04665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPG59_04670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPG59_04705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPG59_04710	COG0049	tRNA binding
IPG59_04715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPG59_04725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPG59_04730	COG1649	PFAM Uncharacterised BCR, COG1649
IPG59_04745	COG0534	Mate efflux family protein
IPG59_04755	COG0180	Tryptophanyl-tRNA synthetase
IPG59_04765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPG59_04770	COG2239	Acts as a magnesium transporter
IPG59_04775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPG59_04800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPG59_04810	COG0443	Heat shock 70 kDa protein
IPG59_04815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPG59_04820	COG0316	Belongs to the HesB IscA family
IPG59_04840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IPG59_04850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPG59_04860	COG0795	lipopolysaccharide-transporting ATPase activity
IPG59_04865	COG1137	ATPase activity
IPG59_04885	COG0546	phosphoglycolate phosphatase activity
IPG59_04890	COG0505	Belongs to the CarA family
IPG59_04895	COG1007	ATP synthesis coupled electron transport
IPG59_04925	COG0629	single-stranded DNA binding
IPG59_04930	COG0515	serine threonine protein kinase
IPG59_04930	COG2815	serine threonine protein kinase
IPG59_04960	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPG59_04965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPG59_04970	COG0596	Alpha beta hydrolase
IPG59_04975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPG59_04980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPG59_04985	COG0268	Binds directly to 16S ribosomal RNA
IPG59_05010	COG1968	undecaprenyl-diphosphatase activity
IPG59_05015	COG2815	serine threonine protein kinase
IPG59_05015	COG0515	serine threonine protein kinase
IPG59_05020	COG0515	serine threonine protein kinase
IPG59_05020	COG2815	serine threonine protein kinase
IPG59_05030	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IPG59_05035	COG0095	Lipoate-protein ligase
IPG59_05060	COG0527	aspartate kinase activity
IPG59_05070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPG59_05070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPG59_05080	COG1063	alcohol dehydrogenase
IPG59_05095	COG0730	response to heat
IPG59_05140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPG59_05140	COG0574	Belongs to the PEP-utilizing enzyme family
IPG59_05155	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_05185	COG0714	Associated with various cellular activities
IPG59_05205	COG1024	Enoyl-CoA hydratase
IPG59_05205	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPG59_05225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IPG59_05240	COG0017	Asparaginyl-tRNA synthetase
IPG59_05340	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
IPG59_05350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPG59_05360	COG2197	response regulator
IPG59_05385	COG0515	serine threonine protein kinase
IPG59_05385	COG2815	serine threonine protein kinase
IPG59_05390	COG2205	protein histidine kinase activity
IPG59_05420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPG59_05425	COG0556	nucleotide-excision repair
IPG59_05475	COG0071	Belongs to the small heat shock protein (HSP20) family
IPG59_05540	COG1671	Belongs to the UPF0178 family
IPG59_05550	COG2801	Transposase and inactivated derivatives
IPG59_05560	COG0494	nUDIX hydrolase
IPG59_05575	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IPG59_05635	COG4221	oxidoreductase activity
IPG59_05655	COG2094	Belongs to the DNA glycosylase MPG family
IPG59_05670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPG59_05680	COG0154	amidase activity
IPG59_05685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPG59_05690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPG59_05695	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_05705	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IPG59_05750	COG2197	response regulator
IPG59_05760	COG2815	serine threonine protein kinase
IPG59_05760	COG0515	serine threonine protein kinase
IPG59_05775	COG4232	protein-disulfide reductase activity
IPG59_05835	COG0367	asparagine synthase
IPG59_05840	COG0463	Glycosyl transferase, family 2
IPG59_05875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IPG59_05875	COG0426	domain, Protein
IPG59_05880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPG59_05885	COG1660	Displays ATPase and GTPase activities
IPG59_05890	COG0242	peptide deformylase activity
IPG59_05915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IPG59_05920	COG1063	alcohol dehydrogenase
IPG59_05930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IPG59_05935	COG2086	electron transfer activity
IPG59_05980	COG1309	transcriptional regulator
IPG59_06030	COG0805	protein transport
IPG59_06035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPG59_06040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPG59_06050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPG59_06060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPG59_06070	COG0360	Binds together with S18 to 16S ribosomal RNA
IPG59_06085	COG4974	Belongs to the 'phage' integrase family
IPG59_06130	COG3654	unkown
IPG59_06160	COG2197	response regulator
IPG59_06180	COG1185	polyribonucleotide nucleotidyltransferase activity
IPG59_06190	COG0776	regulation of translation
IPG59_06195	COG0799	negative regulation of ribosome biogenesis
IPG59_06245	COG1201	RNA secondary structure unwinding
IPG59_06250	COG1793	dna ligase
IPG59_06250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPG59_06255	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPG59_06255	COG1793	dna ligase
IPG59_06260	COG1022	Amp-dependent synthetase and ligase
IPG59_06265	COG2267	carboxylic ester hydrolase activity
IPG59_06330	COG1309	transcriptional regulator
IPG59_06350	COG1993	acr, cog1993
IPG59_06355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPG59_06360	COG2814	Major facilitator Superfamily
IPG59_06365	COG0583	DNA-binding transcription factor activity
IPG59_06385	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IPG59_06390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IPG59_06410	COG0612	Peptidase, M16
IPG59_06430	COG0277	FAD linked oxidase domain protein
IPG59_06440	COG0084	hydrolase, TatD family'
IPG59_06475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPG59_06505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPG59_06520	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPG59_06525	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IPG59_06530	COG1966	Carbon starvation protein
IPG59_06555	COG0406	alpha-ribazole phosphatase activity
IPG59_06565	COG4680	protein conserved in bacteria
IPG59_06590	COG0183	Belongs to the thiolase family
IPG59_06595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPG59_06615	COG0183	Belongs to the thiolase family
IPG59_06670	COG0457	Tetratricopeptide repeat
IPG59_06670	COG0705	Rhomboid family
IPG59_06675	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
IPG59_06680	COG0739	heme binding
IPG59_06690	COG0617	tRNA 3'-terminal CCA addition
IPG59_06695	COG0617	tRNA 3'-terminal CCA addition
IPG59_06705	COG0793	Belongs to the peptidase S41A family
IPG59_06715	COG1607	acyl-coa hydrolase
IPG59_06750	COG0312	modulator of DNA gyrase
IPG59_06760	COG2815	serine threonine protein kinase
IPG59_06760	COG0515	serine threonine protein kinase
IPG59_06785	COG0596	Alpha beta hydrolase
IPG59_06790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IPG59_06800	COG0656	L-ascorbic acid biosynthetic process
IPG59_06810	COG5002	protein histidine kinase activity
IPG59_06825	COG3104	oligopeptide transport
IPG59_06845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IPG59_06855	COG1215	transferase activity, transferring glycosyl groups
IPG59_06860	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IPG59_06875	COG0850	regulation of cytokinetic process
IPG59_06880	COG2894	cell division
IPG59_06885	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IPG59_06890	COG0772	Belongs to the SEDS family
IPG59_06905	COG0515	serine threonine protein kinase
IPG59_06905	COG2815	serine threonine protein kinase
IPG59_06975	COG1131	(ABC) transporter
IPG59_06990	COG1819	glycosyl
IPG59_07015	COG0366	Alpha amylase catalytic
IPG59_07035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IPG59_07045	COG0514	ATP-dependent DNA helicase (RecQ)
IPG59_07050	COG0784	Response regulator, receiver
IPG59_07055	COG4251	negative regulation of phosphorylation
IPG59_07075	COG1297	OPT oligopeptide transporter protein
IPG59_07080	COG3012	SEC-C Motif Domain Protein
IPG59_07085	COG0488	(ABC) transporter
IPG59_07135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IPG59_07145	COG1764	response to oxidative stress
IPG59_07150	COG0626	cystathionine gamma-synthase activity
IPG59_07160	COG0460	homoserine dehydrogenase
IPG59_07205	COG1408	metallophosphoesterase
IPG59_07210	COG1408	metallophosphoesterase
IPG59_07215	COG0745	RESPONSE REGULATOR receiver
IPG59_07230	COG1309	transcriptional regulator
IPG59_07240	COG2197	response regulator
IPG59_07245	COG0025	NhaP-type Na H and K H
IPG59_07250	COG0659	secondary active sulfate transmembrane transporter activity
IPG59_07280	COG0500	methyltransferase
IPG59_07295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPG59_07315	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IPG59_07315	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IPG59_07375	COG1802	Transcriptional regulator
IPG59_07415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPG59_07445	COG3034	peptidoglycan biosynthetic process
IPG59_07470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPG59_07475	COG0631	protein serine/threonine phosphatase activity
IPG59_07485	COG2815	serine threonine protein kinase
IPG59_07485	COG0515	serine threonine protein kinase
IPG59_07490	COG0424	maF-like protein
IPG59_07495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPG59_07510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPG59_07515	COG0463	Glycosyl transferase, family 2
IPG59_07540	COG0481	GTPase activity
IPG59_07545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IPG59_07545	COG0646	methionine synthase
IPG59_07620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IPG59_07625	COG3119	arylsulfatase activity
IPG59_07670	COG0222	ribosome binding
IPG59_07675	COG1410	methionine synthase
IPG59_07675	COG0646	methionine synthase
IPG59_07680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IPG59_07685	COG0626	cystathionine gamma-synthase activity
IPG59_07695	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPG59_07695	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPG59_07705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG59_07715	COG0745	RESPONSE REGULATOR receiver
IPG59_07725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPG59_07730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPG59_07735	COG2815	serine threonine protein kinase
IPG59_07735	COG0515	serine threonine protein kinase
IPG59_07750	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPG59_07755	COG0740	serine-type endopeptidase activity
IPG59_07760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPG59_07770	COG0515	serine threonine protein kinase
IPG59_07770	COG2815	serine threonine protein kinase
IPG59_07795	COG2986	histidine ammonia-lyase
IPG59_07815	COG2815	serine threonine protein kinase
IPG59_07815	COG0515	serine threonine protein kinase
IPG59_07825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPG59_07830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPG59_07865	COG1074	ATP-dependent DNA helicase activity
IPG59_07885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPG59_07890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPG59_07910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPG59_07915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPG59_07920	COG0653	protein targeting
IPG59_07925	COG1214	PFAM Peptidase M22, glycoprotease
IPG59_07930	COG0456	acetyltransferase
IPG59_07940	COG0697	spore germination
IPG59_07950	COG1408	metallophosphoesterase
IPG59_07965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPG59_07975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPG59_07980	COG0475	glutathione-regulated potassium exporter activity
IPG59_07995	COG0681	Belongs to the peptidase S26 family
IPG59_08025	COG0753	catalase activity
IPG59_08075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IPG59_08080	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPG59_08090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IPG59_08105	COG0535	radical SAM domain protein
IPG59_08110	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IPG59_08125	COG2226	methyltransferase
IPG59_08135	COG0598	Magnesium transport protein CorA
IPG59_08145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPG59_08165	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPG59_08165	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPG59_08170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPG59_08185	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPG59_08195	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IPG59_08260	COG0204	Acyl-transferase
IPG59_08295	COG3260	NADH ubiquinone oxidoreductase 20
IPG59_08300	COG0649	NAD binding
IPG59_08305	COG0651	ATP synthesis coupled electron transport
IPG59_08320	COG0651	ATP synthesis coupled electron transport
IPG59_08325	COG0640	Transcriptional regulator
IPG59_08330	COG0288	reversible hydration of carbon dioxide
IPG59_08335	COG1151	hydroxylamine reductase activity
IPG59_08340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IPG59_08345	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IPG59_08355	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPG59_08365	COG0427	acetyl-CoA hydrolase
IPG59_08370	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IPG59_08375	COG0298	carbon dioxide binding
IPG59_08385	COG0309	Hydrogenase expression formation protein (HypE)
IPG59_08390	COG0589	response to stress
IPG59_08400	COG0204	Acyl-transferase
IPG59_08410	COG0589	response to stress
IPG59_08420	COG0589	response to stress
IPG59_08445	COG0589	response to stress
IPG59_08455	COG0589	response to stress
IPG59_08470	COG0589	response to stress
IPG59_08475	COG0589	response to stress
IPG59_08480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPG59_08480	COG0574	Belongs to the PEP-utilizing enzyme family
IPG59_08500	COG0561	phosphatase activity
IPG59_08510	COG3706	GGDEF domain
IPG59_08530	COG5002	protein histidine kinase activity
IPG59_08535	COG2197	response regulator
IPG59_08550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPG59_08625	COG3420	alginic acid biosynthetic process
IPG59_08630	COG2226	methyltransferase
IPG59_08635	COG1309	transcriptional regulator
IPG59_08640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPG59_08675	COG2264	protein methyltransferase activity
IPG59_08700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPG59_08715	COG2205	protein histidine kinase activity
IPG59_08720	COG3177	Filamentation induced by cAMP protein fic
IPG59_08800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPG59_08800	COG4651	solute:proton antiporter activity
IPG59_08825	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IPG59_08865	COG0454	-acetyltransferase
IPG59_08880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPG59_08885	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPG59_08910	COG3953	SLT domain
IPG59_08910	COG5280	Phage tail tape measure protein TP901
IPG59_08920	COG5002	protein histidine kinase activity
IPG59_08935	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPG59_08940	COG0542	response to heat
IPG59_08945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPG59_08980	COG0151	Belongs to the GarS family
IPG59_08985	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IPG59_08990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPG59_08995	COG0047	phosphoribosylformylglycinamidine synthase activity
IPG59_09005	COG0138	bifunctional purine biosynthesis protein purh
IPG59_09010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IPG59_09015	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IPG59_09075	COG0463	Glycosyl transferase, family 2
IPG59_09100	COG0492	ferredoxin-NADP+ reductase activity
IPG59_09105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IPG59_09110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPG59_09115	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPG59_09120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IPG59_09145	COG0587	DNA-directed DNA polymerase activity
IPG59_09150	COG0587	DNA-directed DNA polymerase activity
IPG59_09165	COG0632	four-way junction helicase activity
IPG59_09185	COG1547	Domain of unknown function (DUF309)
IPG59_09205	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IPG59_09215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IPG59_09230	COG0577	efflux transmembrane transporter activity
IPG59_09315	COG1960	acyl-CoA dehydrogenase activity
IPG59_09330	COG0861	Integral membrane protein TerC family
IPG59_09335	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPG59_09345	COG0335	large ribosomal subunit rRNA binding
IPG59_09350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPG59_09355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPG59_09365	COG1187	pseudouridine synthase activity
IPG59_09385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IPG59_09390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPG59_09390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPG59_09400	COG0157	Belongs to the NadC ModD family
IPG59_09425	COG0542	response to heat
IPG59_09490	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IPG59_09515	COG0768	penicillin binding
IPG59_09530	COG1077	Cell shape determining protein MreB Mrl
IPG59_09575	COG1316	TRANSCRIPTIONal
IPG59_09580	COG0859	PFAM glycosyl transferase family 9
IPG59_09585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPG59_09600	COG0037	tRNA processing
IPG59_09605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPG59_09620	COG1090	epimerase
IPG59_09625	COG1366	Belongs to the anti-sigma-factor antagonist family
IPG59_09625	COG2202	Pas domain
IPG59_09635	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_09685	COG3266	domain, Protein
IPG59_09685	COG1361	Conserved repeat domain
IPG59_09685	COG2911	Protein conserved in bacteria
IPG59_09700	COG2084	Dehydrogenase
IPG59_09710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPG59_09715	COG1100	Small GTP-binding protein
IPG59_09720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPG59_09725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IPG59_09730	COG2890	protein-(glutamine-N5) methyltransferase activity
IPG59_09730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IPG59_09735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPG59_09755	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IPG59_09805	COG0484	heat shock protein binding
IPG59_09820	COG3781	membrane
IPG59_09860	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
IPG59_09875	COG0745	RESPONSE REGULATOR receiver
IPG59_09890	COG0442	prolyl-tRNA aminoacylation
IPG59_09895	COG0077	Prephenate dehydratase
IPG59_09895	COG1605	Chorismate mutase
IPG59_09905	COG0383	alpha-mannosidase activity
IPG59_09920	COG0039	L-malate dehydrogenase activity
IPG59_09930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPG59_09935	COG0564	pseudouridine synthase activity
IPG59_09975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPG59_09985	COG0606	chelatase, subunit chli
IPG59_10035	COG0745	RESPONSE REGULATOR receiver
IPG59_10040	COG2205	protein histidine kinase activity
IPG59_10055	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPG59_10075	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IPG59_10115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPG59_10155	COG1100	Small GTP-binding protein
IPG59_10160	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IPG59_10190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPG59_10215	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPG59_10220	COG1994	Peptidase M50
IPG59_10250	COG5002	protein histidine kinase activity
IPG59_10255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPG59_10280	COG0372	Belongs to the citrate synthase family
IPG59_10295	COG2944	sequence-specific DNA binding
IPG59_10310	COG0515	serine threonine protein kinase
IPG59_10335	COG1012	belongs to the aldehyde dehydrogenase family
IPG59_10335	COG1454	alcohol dehydrogenase
IPG59_10365	COG0363	glucosamine-6-phosphate deaminase activity
IPG59_10370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPG59_10380	COG0443	Heat shock 70 kDa protein
IPG59_10385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IPG59_10395	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPG59_10425	COG0058	SHG alpha-glucan phosphorylase activity
IPG59_10430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPG59_10515	COG1078	dGTPase activity
IPG59_10520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IPG59_10530	COG1837	Belongs to the UPF0109 family
IPG59_10565	COG0509	glycine decarboxylation via glycine cleavage system
IPG59_10595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPG59_10625	COG1083	cytidylyl-transferase
IPG59_10630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPG59_10640	COG4106	trans-aconitate 2-methyltransferase activity
IPG59_10645	COG2226	methyltransferase
IPG59_10650	COG2089	acid synthase
IPG59_10665	COG0463	Glycosyl transferase, family 2
IPG59_10680	COG2755	lipolytic protein G-D-S-L family
IPG59_10680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPG59_10690	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_10695	COG1083	cytidylyl-transferase
IPG59_10715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG59_10720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPG59_10725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPG59_10730	COG2089	acid synthase
IPG59_10735	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPG59_10745	COG0107	imidazoleglycerol-phosphate synthase activity
IPG59_10755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPG59_10770	COG1086	Polysaccharide biosynthesis protein
IPG59_10775	COG1696	Membrane protein involved in D-alanine export
IPG59_10790	COG0154	amidase activity
IPG59_10810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPG59_10815	COG0772	Belongs to the SEDS family
IPG59_10820	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPG59_10830	COG0217	transcriptional regulatory protein
IPG59_10835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IPG59_10840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPG59_10845	COG0215	cysteine-tRNA ligase activity
IPG59_10870	COG0012	GTP binding
IPG59_10885	COG0617	tRNA 3'-terminal CCA addition
IPG59_10885	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IPG59_10885	COG3620	sequence-specific DNA binding
IPG59_10895	COG2268	Band 7 protein
IPG59_10910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IPG59_10915	COG0181	hydroxymethylbilane synthase activity
IPG59_10920	COG1587	Uroporphyrinogen-III synthase
IPG59_10925	COG2203	Gaf domain
IPG59_10925	COG2199	diguanylate cyclase activity
IPG59_10930	COG0113	porphobilinogen synthase activity
IPG59_10950	COG2205	protein histidine kinase activity
IPG59_11000	COG0314	molybdopterin synthase activity
IPG59_11005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPG59_11010	COG0315	cyclic pyranopterin monophosphate synthase activity
IPG59_11010	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPG59_11050	COG0456	acetyltransferase
IPG59_11060	COG2205	protein histidine kinase activity
IPG59_11060	COG0784	Response regulator, receiver
IPG59_11060	COG5002	protein histidine kinase activity
IPG59_11070	COG2081	HI0933 family
IPG59_11085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IPG59_11090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IPG59_11110	COG0745	RESPONSE REGULATOR receiver
IPG59_11115	COG0745	RESPONSE REGULATOR receiver
IPG59_11120	COG0693	protein deglycase activity
IPG59_11130	COG0662	Cupin 2, conserved barrel domain protein
IPG59_11135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IPG59_11150	COG0667	Aldo Keto reductase
IPG59_11180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPG59_11185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IPG59_11220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IPG59_11220	COG3608	succinylglutamate desuccinylase aspartoacylase
IPG59_11225	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPG59_11230	COG2080	2 iron, 2 sulfur cluster binding
IPG59_11255	COG3844	kynureninase activity
IPG59_11260	COG0612	Peptidase, M16
IPG59_11265	COG3547	Transposase (IS116 IS110 IS902 family)
IPG59_11325	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IPG59_11365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IPG59_11380	COG0463	Glycosyl transferase, family 2
IPG59_11385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPG59_11390	COG0110	maltose O-acetyltransferase activity
IPG59_11395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG59_11410	COG0673	inositol 2-dehydrogenase activity
IPG59_11445	COG1505	serine-type exopeptidase activity
IPG59_11470	COG0297	glycogen (starch) synthase activity
IPG59_11515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPG59_11565	COG2718	Belongs to the UPF0229 family
IPG59_11585	COG1970	mechanosensitive ion channel activity
IPG59_11725	COG0714	Associated with various cellular activities
IPG59_11740	COG0793	Belongs to the peptidase S41A family
IPG59_11745	COG0793	Belongs to the peptidase S41A family
IPG59_11750	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IPG59_11780	COG0456	acetyltransferase
IPG59_11790	COG1335	isochorismatase
IPG59_11850	COG2801	Transposase and inactivated derivatives
IPG59_11855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPG59_11890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPG59_11905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IPG59_11905	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IPG59_11920	COG0346	lactoylglutathione lyase activity
IPG59_11925	COG1830	Aldolase
IPG59_11975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPG59_11980	COG2171	N-acyltransferase activity
IPG59_11985	COG1473	amidohydrolase
IPG59_12050	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_12075	COG0542	response to heat
IPG59_12115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPG59_12155	COG0006	proline dipeptidase activity
IPG59_12190	COG0563	adenylate kinase activity
IPG59_12200	COG0540	Belongs to the ATCase OTCase family
IPG59_12220	COG0445	tRNA wobble uridine modification
IPG59_12245	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPG59_12285	COG2234	aminopeptidase activity
IPG59_12295	COG1063	alcohol dehydrogenase
IPG59_12305	COG1063	alcohol dehydrogenase
IPG59_12320	COG0662	Cupin 2, conserved barrel domain protein
IPG59_12320	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IPG59_12330	COG1960	acyl-CoA dehydrogenase activity
IPG59_12340	COG0735	belongs to the Fur family
IPG59_12345	COG1690	Belongs to the RtcB family
IPG59_12370	COG0069	glutamate synthase activity
IPG59_12385	COG0308	aminopeptidase N
IPG59_12435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPG59_12475	COG0784	Response regulator, receiver
IPG59_12475	COG2205	protein histidine kinase activity
IPG59_12480	COG0793	Belongs to the peptidase S41A family
IPG59_12485	COG0442	prolyl-tRNA aminoacylation
IPG59_12500	COG0434	BtpA family
IPG59_12505	COG0750	zinc metalloprotease
IPG59_12515	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPG59_12660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPG59_12710	COG2226	methyltransferase
IPG59_12760	COG0793	Belongs to the peptidase S41A family
IPG59_12785	COG0793	Belongs to the peptidase S41A family
IPG59_12930	COG0501	Belongs to the peptidase M48B family
IPG59_12940	COG0183	Belongs to the thiolase family
IPG59_12945	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPG59_12945	COG1024	Enoyl-CoA hydratase
IPG59_12965	COG1982	Orn Lys Arg decarboxylase major
IPG59_12970	COG3854	ATPases associated with a variety of cellular activities
IPG59_12985	COG0563	adenylate kinase activity
IPG59_12990	COG0285	dihydrofolate synthase activity
IPG59_13000	COG0612	Peptidase, M16
IPG59_13005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IPG59_13010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPG59_13015	COG0531	amino acid
IPG59_13035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPG59_13045	COG0542	response to heat
IPG59_13050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPG59_13065	COG0237	dephospho-CoA kinase activity
IPG59_13110	COG2050	protein possibly involved in aromatic compounds catabolism
IPG59_13135	COG3485	protocatechuate 3,4-dioxygenase
IPG59_13160	COG0706	membrane insertase activity
IPG59_13165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPG59_13170	COG0594	ribonuclease P activity
IPG59_13180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPG59_13185	COG0592	DNA-directed DNA polymerase activity
IPG59_13220	COG1253	flavin adenine dinucleotide binding
IPG59_13275	COG0328	RNA-DNA hybrid ribonuclease activity
IPG59_13280	COG0183	Belongs to the thiolase family
IPG59_13285	COG1024	Enoyl-CoA hydratase
IPG59_13285	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPG59_13295	COG4178	(ABC) transporter
IPG59_13345	COG0010	Belongs to the arginase family
IPG59_13350	COG0590	tRNA wobble adenosine to inosine editing
IPG59_13370	COG0484	heat shock protein binding
IPG59_13390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPG59_13410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPG59_13415	COG1960	acyl-CoA dehydrogenase activity
IPG59_13515	COG0124	histidyl-tRNA synthetase
IPG59_13525	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IPG59_13575	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_13590	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IPG59_13605	COG4453	Protein conserved in bacteria
IPG59_13700	COG1164	Oligoendopeptidase f
IPG59_13725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IPG59_13730	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPG59_13750	COG0237	dephospho-CoA kinase activity
IPG59_13755	COG2211	Major facilitator Superfamily
IPG59_13780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPG59_13835	COG1937	Protein conserved in bacteria
IPG59_13855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPG59_13875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPG59_13910	COG4221	oxidoreductase activity
IPG59_13940	COG0739	heme binding
IPG59_13940	COG0741	lytic transglycosylase activity
IPG59_13940	COG1196	nuclear chromosome segregation
IPG59_13945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPG59_13955	COG1126	abc transporter atp-binding protein
IPG59_13960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IPG59_13980	COG2309	aminopeptidase activity
IPG59_14105	COG0519	Catalyzes the synthesis of GMP from XMP
IPG59_14105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPG59_14115	COG0542	response to heat
IPG59_14145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG59_14170	COG0019	diaminopimelate decarboxylase activity
IPG59_14200	COG2211	Major facilitator Superfamily
IPG59_14255	COG1960	acyl-CoA dehydrogenase activity
IPG59_14310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG59_14315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IPG59_14335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG59_14340	COG0083	homoserine kinase activity
IPG59_14375	COG0793	Belongs to the peptidase S41A family
IPG59_14395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPG59_14405	COG0492	ferredoxin-NADP+ reductase activity
IPG59_14420	COG1696	Membrane protein involved in D-alanine export
IPG59_14470	COG1741	Belongs to the pirin family
IPG59_14495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IPG59_14505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPG59_14510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPG59_14525	COG2201	protein-glutamate methylesterase activity
IPG59_14530	COG3300	MHYT domain
IPG59_14530	COG5001	Diguanylate cyclase
IPG59_14555	COG0724	RNA recognition motif
IPG59_14585	COG0492	ferredoxin-NADP+ reductase activity
IPG59_14585	COG3118	belongs to the thioredoxin family
IPG59_14595	COG3118	belongs to the thioredoxin family
IPG59_14600	COG5002	protein histidine kinase activity
IPG59_14655	COG0659	secondary active sulfate transmembrane transporter activity
IPG59_14705	COG0358	DNA primase activity
IPG59_14715	COG1253	flavin adenine dinucleotide binding
IPG59_14780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IPG59_14785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IPG59_14815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IPG59_14870	COG1285	pathogenesis
IPG59_14880	COG0667	Aldo Keto reductase
IPG59_14915	COG0205	6-phosphofructokinase activity
IPG59_14920	COG3781	membrane
IPG59_14930	COG2205	protein histidine kinase activity
IPG59_14950	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPG59_14965	COG1091	dTDP-4-dehydrorhamnose reductase activity
IPG59_14975	COG4691	Plasmid stability protein
IPG59_14985	COG2755	lipolytic protein G-D-S-L family
IPG59_14985	COG0657	acetylesterase activity
IPG59_14995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPG59_15080	COG0741	lytic transglycosylase activity
IPG59_15080	COG1196	nuclear chromosome segregation
IPG59_15080	COG0739	heme binding
IPG59_15090	COG0438	transferase activity, transferring glycosyl groups
IPG59_15095	COG0297	glycogen (starch) synthase activity
IPG59_15115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPG59_15120	COG0463	Glycosyl transferase, family 2
IPG59_15130	COG0420	3'-5' exonuclease activity
IPG59_15135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPG59_15140	COG0454	-acetyltransferase
IPG59_15145	COG0359	binds to the 23S rRNA
IPG59_15165	COG1228	amidohydrolase
IPG59_15180	COG0492	ferredoxin-NADP+ reductase activity
IPG59_15185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPG59_15190	COG0717	Belongs to the dCTP deaminase family
IPG59_15220	COG0714	Associated with various cellular activities
IPG59_15225	COG0752	glycyl-tRNA synthetase alpha subunit
IPG59_15235	COG1940	carbohydrate kinase activity
IPG59_15240	COG2234	aminopeptidase activity
IPG59_15255	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_15260	COG1846	Transcriptional regulator
IPG59_15315	COG1242	4 iron, 4 sulfur cluster binding
IPG59_15325	COG3959	Transketolase, thiamine diphosphate binding domain
IPG59_15400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IPG59_15410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPG59_15435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPG59_15460	COG0251	oxidation-reduction process
IPG59_15520	COG2132	Multicopper oxidase
IPG59_15525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IPG59_15530	COG1640	4-alpha-glucanotransferase
IPG59_15540	COG0357	Ribosomal RNA small subunit methyltransferase G
IPG59_15550	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPG59_15560	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPG59_15580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPG59_15620	COG2385	sporulation resulting in formation of a cellular spore
IPG59_15625	COG0745	RESPONSE REGULATOR receiver
IPG59_15640	COG3549	Plasmid maintenance system killer
IPG59_15695	COG3848	Pyruvate phosphate dikinase
IPG59_15695	COG0574	Belongs to the PEP-utilizing enzyme family
IPG59_15710	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IPG59_15715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPG59_15715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPG59_15720	COG0307	riboflavin synthase, alpha
IPG59_15785	COG0163	prenyltransferase activity
IPG59_15790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IPG59_15805	COG0724	RNA recognition motif
IPG59_15820	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPG59_15825	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPG59_15830	COG0649	NAD binding
IPG59_15835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPG59_15840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPG59_15845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPG59_15850	COG0571	ribonuclease III activity
IPG59_15860	COG0539	negative regulation of cytoplasmic translation
IPG59_15865	COG0539	negative regulation of cytoplasmic translation
IPG59_15870	COG0427	acetyl-CoA hydrolase
IPG59_15915	COG0714	Associated with various cellular activities
IPG59_15930	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IPG59_15950	COG1595	DNA-templated transcription, initiation
IPG59_15970	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IPG59_15980	COG1543	Belongs to the glycosyl hydrolase 57 family
IPG59_15985	COG0469	pyruvate kinase activity
IPG59_15990	COG0784	Response regulator, receiver
IPG59_15990	COG2205	protein histidine kinase activity
IPG59_15995	COG2814	Major facilitator Superfamily
IPG59_16020	COG0396	ATPase activity
IPG59_16025	COG0719	Fe-S assembly protein
IPG59_16030	COG0719	Fe-S assembly protein
IPG59_16035	COG2146	nitrite reductase [NAD(P)H] activity
IPG59_16040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IPG59_16045	COG0822	iron-sulfur transferase activity
IPG59_16050	COG2151	metal-sulfur cluster biosynthetic enzyme
IPG59_16075	COG0489	protein tyrosine kinase activity
IPG59_16080	COG0497	DNA recombination
IPG59_16090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPG59_16100	COG5002	protein histidine kinase activity
IPG59_16110	COG3659	wide pore channel activity
IPG59_16125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IPG59_16130	COG0416	fatty acid biosynthetic process
IPG59_16145	COG0402	S-adenosylhomocysteine deaminase activity
IPG59_16150	COG3706	GGDEF domain
IPG59_16155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPG59_16160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPG59_16175	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_16180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IPG59_16185	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IPG59_16195	COG1546	Belongs to the CinA family
IPG59_16195	COG1058	Belongs to the CinA family
IPG59_16210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPG59_16215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IPG59_16230	COG0501	Belongs to the peptidase M48B family
IPG59_16290	COG0584	glycerophosphoryl diester phosphodiesterase
IPG59_16300	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IPG59_16315	COG2610	gluconate transmembrane transporter activity
IPG59_16340	COG3654	unkown
IPG59_16350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IPG59_16365	COG2814	Major facilitator Superfamily
IPG59_16375	COG1733	regulation of RNA biosynthetic process
IPG59_16390	COG1054	Belongs to the UPF0176 family
IPG59_16405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPG59_16425	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IPG59_16450	COG1027	Aspartate ammonia-lyase
IPG59_16455	COG1435	thymidine kinase activity
IPG59_16475	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IPG59_16480	COG0183	Belongs to the thiolase family
IPG59_16485	COG0686	Belongs to the AlaDH PNT family
IPG59_16490	COG0708	Exodeoxyribonuclease III
IPG59_16500	COG0702	epimerase
IPG59_16520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IPG59_16535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPG59_16540	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IPG59_16555	COG0506	proline dehydrogenase activity
IPG59_16590	COG0493	'glutamate synthase
IPG59_16595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPG59_16595	COG0167	dihydroorotate dehydrogenase activity
IPG59_16620	COG0628	permease
IPG59_16635	COG2723	6-phospho-beta-galactosidase activity
IPG59_16640	COG4232	protein-disulfide reductase activity
IPG59_16650	COG0072	phenylalanine-tRNA ligase activity
IPG59_16655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPG59_16660	COG1051	belongs to the nudix hydrolase family
IPG59_16670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPG59_16685	COG1799	cell septum assembly
IPG59_16690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IPG59_16700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IPG59_16705	COG0825	malonyl-CoA metabolic process
IPG59_16720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPG59_16730	COG0537	adenosine 5'-monophosphoramidase activity
IPG59_16740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPG59_16745	COG0459	protein refolding
IPG59_16750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IPG59_16770	COG2124	cytochrome p450
IPG59_16785	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IPG59_16795	COG1335	isochorismatase
IPG59_16840	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IPG59_16855	COG3237	CsbD-like
IPG59_16880	COG0363	glucosamine-6-phosphate deaminase activity
IPG59_16890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IPG59_16895	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IPG59_16900	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IPG59_16905	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IPG59_16910	COG0235	Class ii aldolase
IPG59_16920	COG0515	serine threonine protein kinase
IPG59_16920	COG2815	serine threonine protein kinase
IPG59_16945	COG5002	protein histidine kinase activity
IPG59_16955	COG0745	RESPONSE REGULATOR receiver
IPG59_16960	COG2204	response regulator
IPG59_16990	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_17010	COG2205	protein histidine kinase activity
IPG59_17100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPG59_17115	COG0589	response to stress
IPG59_17190	COG1072	(Pantothenic acid kinase))
IPG59_17195	COG2070	2-Nitropropane dioxygenase
IPG59_17240	COG0784	Response regulator, receiver
IPG59_17240	COG5002	protein histidine kinase activity
IPG59_17240	COG2205	protein histidine kinase activity
IPG59_17275	COG0584	glycerophosphoryl diester phosphodiesterase
IPG59_17300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPG59_17315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPG59_17320	COG0495	leucyl-tRNA aminoacylation
IPG59_17335	COG1086	Polysaccharide biosynthesis protein
IPG59_17340	COG1606	tRNA processing
IPG59_17345	COG1691	(AIR) carboxylase
IPG59_17360	COG0516	GMP reductase activity
IPG59_17365	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IPG59_17405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IPG59_17425	COG2176	DNA-directed DNA polymerase activity
IPG59_17460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPG59_17485	COG2267	carboxylic ester hydrolase activity
IPG59_17495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPG59_17500	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IPG59_17515	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPG59_17520	COG2181	nitrate reductase activity
IPG59_17530	COG1140	nitrate reductase beta subunit
IPG59_17535	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPG59_17540	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IPG59_17550	COG1959	2 iron, 2 sulfur cluster binding
IPG59_17560	COG2199	diguanylate cyclase activity
IPG59_17560	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IPG59_17580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPG59_17590	COG0210	DNA helicase
IPG59_17595	COG0105	UTP biosynthetic process
IPG59_17635	COG3093	addiction module antidote protein HigA
IPG59_17690	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPG59_17705	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPG59_17725	COG1077	Cell shape determining protein MreB Mrl
IPG59_17790	COG0586	Pfam SNARE associated Golgi protein
IPG59_17815	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IPG59_17875	COG3540	Alkaline phosphatase
IPG59_17940	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
IPG59_17950	COG1024	Enoyl-CoA hydratase
IPG59_17960	COG1024	Enoyl-CoA hydratase
IPG59_17975	COG0126	phosphoglycerate kinase activity
IPG59_17975	COG0149	triose-phosphate isomerase activity
IPG59_17980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IPG59_17985	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IPG59_17990	COG1024	Enoyl-CoA hydratase
IPG59_17990	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPG59_18000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IPG59_18005	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPG59_18025	COG0142	geranyltranstransferase activity
IPG59_18030	COG1333	cytochrome c biogenesis protein
IPG59_18035	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPG59_18050	COG1012	belongs to the aldehyde dehydrogenase family
IPG59_18070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPG59_18075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IPG59_18085	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPG59_18090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPG59_18095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPG59_18115	COG3220	belongs to the UPF0276 family
IPG59_18125	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IPG59_18135	COG2385	sporulation resulting in formation of a cellular spore
IPG59_18135	COG2247	cell wall binding repeat
IPG59_18160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IPG59_18180	COG0616	signal peptide processing
IPG59_18200	COG1175	transmembrane transport
IPG59_18205	COG0811	peptide transport
IPG59_18230	COG2884	Cell division ATP-binding protein ftsE
IPG59_18240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPG59_18245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPG59_18260	COG0531	amino acid
IPG59_18265	COG1692	metallophosphoesterase
IPG59_18270	COG0613	PHP domain protein
IPG59_18290	COG1530	ribonuclease E activity
IPG59_18305	COG0735	belongs to the Fur family
IPG59_18310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPG59_18325	COG4399	Belongs to the UPF0754 family
IPG59_18340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPG59_18345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IPG59_18420	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_18440	COG0251	oxidation-reduction process
IPG59_18445	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IPG59_18475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPG59_18480	COG0196	riboflavin kinase activity
IPG59_18485	COG0187	DNA topoisomerase II activity
IPG59_18500	COG1663	tetraacyldisaccharide 4'-kinase activity
IPG59_18505	COG1519	Transferase
IPG59_18510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPG59_18520	COG0052	Belongs to the universal ribosomal protein uS2 family
IPG59_18525	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPG59_18530	COG0528	UMP kinase activity
IPG59_18540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPG59_18580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IPG59_18595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPG59_18600	COG0860	N-Acetylmuramoyl-L-alanine amidase
IPG59_18605	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPG59_18630	COG1131	(ABC) transporter
IPG59_18635	COG0415	Belongs to the DNA photolyase family
IPG59_18640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IPG59_18645	COG0745	RESPONSE REGULATOR receiver
IPG59_18650	COG5002	protein histidine kinase activity
IPG59_18655	COG0659	secondary active sulfate transmembrane transporter activity
IPG59_18665	COG2267	carboxylic ester hydrolase activity
IPG59_18685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IPG59_18690	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPG59_18695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPG59_18695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPG59_18715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPG59_18725	COG0194	GDP metabolic process
IPG59_18735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IPG59_18745	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
IPG59_18755	COG0542	response to heat
IPG59_18760	COG0484	heat shock protein binding
IPG59_18770	COG2199	diguanylate cyclase activity
IPG59_18770	COG2203	Gaf domain
IPG59_18800	COG0629	single-stranded DNA binding
IPG59_18820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPG59_18825	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPG59_18830	COG0776	regulation of translation
IPG59_18835	COG0673	inositol 2-dehydrogenase activity
IPG59_18850	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPG59_18855	COG0740	serine-type endopeptidase activity
IPG59_18860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPG59_18865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPG59_18870	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IPG59_18880	COG1960	acyl-CoA dehydrogenase activity
IPG59_18890	COG3177	Filamentation induced by cAMP protein fic
IPG59_18920	COG3177	Filamentation induced by cAMP protein fic
IPG59_18925	COG2234	aminopeptidase activity
IPG59_18965	COG0017	Asparaginyl-tRNA synthetase
IPG59_18985	COG0668	transmembrane transport
IPG59_18990	COG1760	l-serine dehydratase
IPG59_18995	COG0515	serine threonine protein kinase
IPG59_18995	COG2815	serine threonine protein kinase
IPG59_19000	COG0515	serine threonine protein kinase
IPG59_19000	COG2815	serine threonine protein kinase
IPG59_19005	COG0330	HflC and HflK could
IPG59_19010	COG0515	serine threonine protein kinase
IPG59_19010	COG2815	serine threonine protein kinase
IPG59_19015	COG2815	serine threonine protein kinase
IPG59_19015	COG0515	serine threonine protein kinase
IPG59_19030	COG0590	tRNA wobble adenosine to inosine editing
IPG59_19035	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPG59_19060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPG59_19065	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IPG59_19070	COG3956	TIGRFAM MazG family protein
IPG59_19080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPG59_19090	COG0275	rRNA processing
IPG59_19100	COG0768	penicillin binding
IPG59_19105	COG0728	peptidoglycan biosynthetic process
IPG59_19135	COG0640	Transcriptional regulator
IPG59_19155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPG59_19175	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPG59_19255	COG0737	Belongs to the 5'-nucleotidase family
IPG59_19280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPG59_19305	COG1104	cysteine desulfurase activity
IPG59_19310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IPG59_19315	COG1120	ATPase activity
IPG59_19325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IPG59_19330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPG59_19335	COG0779	Required for maturation of 30S ribosomal subunits
IPG59_19350	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPG59_19360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPG59_19370	COG0776	regulation of translation
IPG59_19375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IPG59_19390	COG0515	serine threonine protein kinase
IPG59_19390	COG2815	serine threonine protein kinase
IPG59_19400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IPG59_19420	COG2205	protein histidine kinase activity
IPG59_19435	COG0859	PFAM glycosyl transferase family 9
IPG59_19455	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
IPG59_19460	COG0778	Nitroreductase
IPG59_19515	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPG59_19530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IPG59_19545	COG0515	serine threonine protein kinase
IPG59_19545	COG2815	serine threonine protein kinase
IPG59_19600	COG2271	Major facilitator Superfamily
IPG59_19615	COG2815	serine threonine protein kinase
IPG59_19615	COG0515	serine threonine protein kinase
IPG59_19620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPG59_19665	COG1012	belongs to the aldehyde dehydrogenase family
IPG59_19670	COG1187	pseudouridine synthase activity
IPG59_19675	COG0589	response to stress
IPG59_19715	COG1215	transferase activity, transferring glycosyl groups
IPG59_19720	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPG59_19725	COG0439	Biotin carboxylase
IPG59_19730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IPG59_19740	COG4974	Belongs to the 'phage' integrase family
IPG59_19750	COG0085	RNA polymerase activity
IPG59_19755	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPG59_19760	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPG59_19765	COG0793	Belongs to the peptidase S41A family
IPG59_19800	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPG59_19800	COG1024	Enoyl-CoA hydratase
IPG59_19875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IPG59_19915	COG1091	dTDP-4-dehydrorhamnose reductase activity
IPG59_19925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IPG59_19935	COG0793	Belongs to the peptidase S41A family
IPG59_19935	COG4946	Tricorn protease homolog
IPG59_19955	COG1316	TRANSCRIPTIONal
IPG59_19965	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPG59_19970	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPG59_19970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPG59_19980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPG59_19985	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPG59_20025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IPG59_20030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPG59_20040	COG1162	GTPase activity
IPG59_20045	COG1217	gtp-binding protein TYPA
IPG59_20050	COG0243	molybdopterin cofactor binding
IPG59_20065	COG5002	protein histidine kinase activity
IPG59_20065	COG5001	Diguanylate cyclase
IPG59_20140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPG59_20155	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPG59_20160	COG2267	carboxylic ester hydrolase activity
IPG59_20170	COG3119	arylsulfatase activity
IPG59_20175	COG1902	pentaerythritol trinitrate reductase activity
IPG59_20180	COG2207	Transcriptional regulator
IPG59_20185	COG0667	Aldo Keto reductase
IPG59_20190	COG1064	alcohol dehydrogenase
IPG59_20200	COG1643	Atp-dependent helicase
IPG59_20205	COG1643	Atp-dependent helicase
IPG59_20225	COG0339	signal peptide processing
IPG59_20260	COG0745	RESPONSE REGULATOR receiver
IPG59_20265	COG2205	protein histidine kinase activity
IPG59_20275	COG0019	diaminopimelate decarboxylase activity
IPG59_20360	COG1294	oxidase, subunit
IPG59_20365	COG1271	oxidase subunit
IPG59_20370	COG3361	conserved protein (COG2071)
IPG59_20460	COG0667	Aldo Keto reductase
IPG59_20480	COG1201	RNA secondary structure unwinding
IPG59_20520	COG3621	Patatin-like phospholipase
IPG59_20565	COG3739	integral membrane protein
IPG59_20595	COG1752	Esterase of the alpha-beta hydrolase superfamily
IPG59_20620	COG4251	negative regulation of phosphorylation
IPG59_20630	COG1012	belongs to the aldehyde dehydrogenase family
IPG59_20640	COG0456	acetyltransferase
IPG59_20695	COG2815	serine threonine protein kinase
IPG59_20695	COG0515	serine threonine protein kinase
IPG59_20705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPG59_20720	COG2155	Conserved Protein
IPG59_20740	COG0288	reversible hydration of carbon dioxide
IPG59_20745	COG2258	MOSC domain
IPG59_20770	COG0010	Belongs to the arginase family
IPG59_20780	COG1132	(ABC) transporter
IPG59_20820	COG1413	lyase activity
IPG59_20825	COG0726	polysaccharide deacetylase
IPG59_20835	COG0842	Transport permease protein
IPG59_20840	COG1129	ABC transporter
IPG59_20840	COG0842	Transport permease protein
IPG59_20845	COG1131	(ABC) transporter
IPG59_20855	COG1309	transcriptional regulator
IPG59_20865	COG1733	regulation of RNA biosynthetic process
IPG59_20885	COG1960	acyl-CoA dehydrogenase activity
IPG59_20910	COG4680	protein conserved in bacteria
IPG59_20915	COG1413	lyase activity
IPG59_20955	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
IPG59_20975	COG3842	ATPase activity
IPG59_20980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IPG59_21000	COG0457	Tetratricopeptide repeat
IPG59_21005	COG3033	Beta-eliminating lyase
IPG59_21010	COG3033	Beta-eliminating lyase
IPG59_21065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IPG59_21100	COG1136	(ABC) transporter
IPG59_21100	COG0577	efflux transmembrane transporter activity
IPG59_21105	COG1136	(ABC) transporter
IPG59_21110	COG3781	membrane
IPG59_21115	COG2326	polyphosphate kinase activity
IPG59_21135	COG1131	(ABC) transporter
IPG59_21155	COG1131	(ABC) transporter
IPG59_21180	COG0569	domain protein
IPG59_21195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPG59_21255	COG0525	valine-tRNA ligase activity
IPG59_21260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPG59_21265	COG0511	ligase activity, forming carbon-carbon bonds
IPG59_21270	COG0439	Biotin carboxylase
IPG59_21280	COG2815	serine threonine protein kinase
IPG59_21280	COG0515	serine threonine protein kinase
IPG59_21300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPG59_21305	COG3118	belongs to the thioredoxin family
IPG59_21310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPG59_21320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IPG59_21325	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IPG59_21340	COG1881	PFAM PEBP family protein
IPG59_21395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPG59_21395	COG3320	Male sterility
IPG59_21400	COG0702	epimerase
IPG59_21455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPG59_21485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPG59_21510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPG59_21530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPG59_21535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPG59_21545	COG1216	Glycosyl transferase, family 2
IPG59_21565	COG0784	Response regulator, receiver
IPG59_21565	COG2205	protein histidine kinase activity
IPG59_21565	COG5002	protein histidine kinase activity
IPG59_21570	COG0745	RESPONSE REGULATOR receiver
IPG59_21575	COG2201	protein-glutamate methylesterase activity
IPG59_21600	COG0835	chemotaxis
IPG59_21610	COG0277	FAD linked oxidase domain protein
IPG59_21615	COG0463	Glycosyl transferase, family 2
IPG59_21630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPG59_21635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPG59_21640	COG1381	Involved in DNA repair and RecF pathway recombination
IPG59_21660	COG0709	Synthesizes selenophosphate from selenide and ATP
IPG59_21665	COG0425	Belongs to the sulfur carrier protein TusA family
IPG59_21695	COG1940	carbohydrate kinase activity
IPG59_21725	COG3224	Antibiotic biosynthesis monooxygenase
IPG59_21755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IPG59_21770	COG1199	ATP-dependent helicase activity
IPG59_21785	COG0306	phosphate transporter
IPG59_21805	COG0859	PFAM glycosyl transferase family 9
IPG59_21850	COG1921	L-seryl-tRNASec selenium transferase activity
IPG59_21865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPG59_21890	COG0051	transcription antitermination factor activity, RNA binding
IPG59_21895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPG59_21900	COG0088	Forms part of the polypeptide exit tunnel
IPG59_21910	COG0089	rRNA binding
IPG59_21915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPG59_21920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPG59_21925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPG59_21930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPG59_21935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPG59_21940	COG0255	Belongs to the universal ribosomal protein uL29 family
IPG59_21945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPG59_21950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPG59_21955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPG59_21960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPG59_21965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPG59_21970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPG59_21975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPG59_21985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPG59_21990	COG1841	ribosomal large subunit assembly
IPG59_21995	COG0200	Binds to the 23S rRNA
IPG59_22000	COG0201	protein transport
IPG59_22005	COG0563	adenylate kinase activity
IPG59_22015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPG59_22020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPG59_22025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPG59_22030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPG59_22035	COG0202	RNA polymerase activity
IPG59_22040	COG0203	ribosomal protein L17
IPG59_22045	COG0101	tRNA pseudouridine synthase activity
IPG59_22050	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPG59_22055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPG59_22080	COG1331	Highly conserved protein containing a thioredoxin domain
IPG59_22085	COG0438	transferase activity, transferring glycosyl groups
IPG59_22115	COG1216	Glycosyl transferase, family 2
IPG59_22220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPG59_22235	COG0393	Putative heavy-metal-binding
IPG59_22360	COG1324	tolerance protein
IPG59_22365	COG1022	Amp-dependent synthetase and ligase
IPG59_22380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPG59_22395	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IPG59_22415	COG5002	protein histidine kinase activity
IPG59_22425	COG2226	methyltransferase
IPG59_22435	COG1132	(ABC) transporter
IPG59_22445	COG0668	transmembrane transport
IPG59_22460	COG2183	response to ionizing radiation
IPG59_22470	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IPG59_22475	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IPG59_22480	COG0714	Associated with various cellular activities
IPG59_22500	COG1028	Short-chain dehydrogenase reductase Sdr
IPG59_22510	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPG59_22515	COG0724	RNA recognition motif
IPG59_22535	COG0515	serine threonine protein kinase
IPG59_22550	COG3459	Glycosyltransferase 36 associated
IPG59_22625	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPG59_22625	COG0493	'glutamate synthase
IPG59_22645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IPG59_22655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IPG59_22660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPG59_22740	COG2234	aminopeptidase activity
IPG59_22840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPG59_22880	COG0717	Belongs to the dCTP deaminase family
IPG59_22945	COG0165	Argininosuccinate lyase
IPG59_22950	COG0137	argininosuccinate synthase activity
IPG59_22955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IPG59_23045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPG59_23050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPG59_23060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPG59_23070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IPG59_23070	COG0140	phosphoribosyl-ATP diphosphatase activity
IPG59_23075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IPG59_23080	COG0438	transferase activity, transferring glycosyl groups
IPG59_23100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPG59_23115	COG4251	negative regulation of phosphorylation
IPG59_23130	COG0724	RNA recognition motif
IPG59_23155	COG3118	belongs to the thioredoxin family
IPG59_23205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPG59_23220	COG4608	Belongs to the ABC transporter superfamily
IPG59_23335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IPG59_23340	COG0322	excinuclease ABC activity
IPG59_23345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPG59_23355	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPG59_23365	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPG59_23385	COG0482	sulfurtransferase activity
IPG59_23395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IPG59_23400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IPG59_23435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPG59_23440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPG59_23445	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IPG59_23450	COG1040	competence protein
IPG59_23455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPG59_23460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPG59_23480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPG59_23485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPG59_23490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan