locus-tag	class	description
IM40_00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
IM40_00015	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
IM40_00020	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IM40_00040	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
IM40_00045	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
IM40_00050	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
IM40_00065	ENOG4105EPD	Oligopeptide transporter, Opt family
IM40_00075	ENOG4107QQG	Dehydrogenase
IM40_00080	ENOG4105J5G	Transferase hexapeptide repeat containing protein
IM40_00085	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
IM40_00090	ENOG4105CAQ	asparagine synthetase
IM40_00105	ENOG4108VIA	integral membrane protein
IM40_00110	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
IM40_00140	ENOG4105CAQ	asparagine synthetase
IM40_00200	ENOG4105CFG	Acts as a chaperone (By similarity)
IM40_00205	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
IM40_00230	ENOG41076HS	cation diffusion facilitator family transporter
IM40_00240	ENOG4105C2M	dna polymerase I
IM40_00245	ENOG4105VG0	50S ribosomal protein l34
IM40_00255	ENOG4107QHF	type ii secretion system protein e
IM40_00260	ENOG4105D7Q	type ii secretion system
IM40_00295	ENOG4105C2X	Arabinose 5-phosphate isomerase
IM40_00320	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
IM40_00325	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
IM40_00330	ENOG4105C2C	drug resistance transporter, Bcr CflA
IM40_00335	ENOG4105D5Q	Arginine ornithine antiporter
IM40_00355	ENOG4105W49	UPF0434 protein
IM40_00365	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
IM40_00370	ENOG4105M6F	mutator MutT protein
IM40_00375	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
IM40_00380	ENOG4105EAH	synthase
IM40_00435	ENOG4108UJU	UPF0301 protein
IM40_00445	ENOG41082FS	50S ribosomal protein L31
IM40_00450	ENOG4105EIE	fructose-bisphosphate aldolase
IM40_00465	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
IM40_00470	ENOG4105CEY	Amp-dependent synthetase and ligase
IM40_00475	ENOG4105CHU	acetyl-coa acetyltransferase
IM40_00485	ENOG4105CSU	acyl-Coa dehydrogenase
IM40_00495	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
IM40_00500	ENOG41066YJ	Beta-lactamase
IM40_00505	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
IM40_00560	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
IM40_00565	ENOG4105CSA	Coproporphyrinogen iii oxidase
IM40_00570	ENOG4105W5Q	DNA repair protein (RadC
IM40_00590	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
IM40_00610	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IM40_00630	ENOG4108ZNX	Heat shock protein
IM40_00655	ENOG41060IM	Heme exporter protein
IM40_00665	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
IM40_00675	ENOG4105N5Q	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
IM40_00680	ENOG4107Z0K	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
IM40_00685	ENOG4108CIF	atp synthase
IM40_00690	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
IM40_00695	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
IM40_00700	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
IM40_00705	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
IM40_00710	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
IM40_00715	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
IM40_00765	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
IM40_00780	ENOG4105Y2X	UPF0335 protein
IM40_00800	ENOG4105C72	UPF0176 protein
IM40_00825	ENOG4105BZU	Histidine kinase
IM40_00840	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
IM40_00855	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
IM40_00900	ENOG4105EYM	Major Facilitator superfamily
IM40_00915	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
IM40_00920	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
IM40_00925	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
IM40_00930	ENOG4107QP8	phosphohexose isomerase
IM40_00955	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
IM40_00960	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
IM40_00975	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
IM40_00980	ENOG4108UJD	30S ribosomal protein S9
IM40_01010	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
IM40_01015	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
IM40_01025	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
IM40_01040	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
IM40_01100	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
IM40_01110	ENOG4105D9N	nucleoside
IM40_01120	ENOG4105G9V	cytochrome C
IM40_01130	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
IM40_01135	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
IM40_01140	ENOG4108JQ5	ABC transporter
IM40_01145	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
IM40_01155	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
IM40_01160	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
IM40_01165	ENOG4105HHA	aminodeoxychorismate lyase
IM40_01180	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
IM40_01200	ENOG4105C72	UPF0176 protein
IM40_01205	ENOG4105WVQ	Fe-S assembly protein IscX
IM40_01215	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
IM40_01235	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
IM40_01245	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
IM40_01255	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
IM40_01260	ENOG4105W0E	50S ribosomal protein L33
IM40_01270	ENOG4107ZT3	family UPF0126
IM40_01290	ENOG4105BZ1	(ABC) transporter
IM40_01305	ENOG4107TNS	sigma 54 modulation protein ribosomal protein S30ea
IM40_01310	ENOG4105DUX	Transporter
IM40_01320	ENOG4105C5H	ABC transporter
IM40_01350	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
IM40_01355	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
IM40_01370	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
IM40_01390	ENOG4105KT5	UmuD protein
IM40_01405	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
IM40_01480	ENOG4105DJB	Major Facilitator Superfamily
IM40_01495	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
IM40_01500	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
IM40_01550	ENOG4105C2I	pirin domain protein
IM40_01560	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
IM40_01575	ENOG4105D1A	Methyltransferase
IM40_01625	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
IM40_01675	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_01715	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
IM40_01720	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
IM40_01725	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
IM40_01740	ENOG4105C3F	Signal peptidase i
IM40_01745	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
IM40_01750	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
IM40_01785	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
IM40_01795	ENOG4105C03	ribonuclease
IM40_01800	ENOG4105VYE	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
IM40_01805	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
IM40_01815	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
IM40_01840	ENOG4105DD5	Flagellar motor switch protein
IM40_01845	ENOG4105FZW	flagellar biosynthesis regulator FlhF
IM40_01855	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
IM40_01880	ENOG4105E39	Enoyl-CoA hydratase
IM40_01885	ENOG4108JA2	transcriptioN-repair coupling factor
IM40_01895	ENOG4108SXK	Transporter Drug Metabolite Exporter family
IM40_01965	ENOG4105DHJ	ABC, transporter
IM40_01980	ENOG4105HFZ	Membrane
IM40_01995	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
IM40_02000	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
IM40_02005	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
IM40_02010	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
IM40_02015	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
IM40_02020	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
IM40_02025	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
IM40_02030	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
IM40_02035	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IM40_02040	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
IM40_02045	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
IM40_02050	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
IM40_02055	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
IM40_02060	ENOG41083MP	50s ribosomal protein l29
IM40_02065	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
IM40_02070	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
IM40_02075	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
IM40_02080	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IM40_02085	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
IM40_02090	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
IM40_02095	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
IM40_02100	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
IM40_02105	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
IM40_02110	ENOG41084HQ	50S ribosomal protein L30
IM40_02115	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
IM40_02125	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
IM40_02130	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IM40_02135	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
IM40_02140	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IM40_02145	ENOG4108ZT0	50S ribosomal protein l17
IM40_02150	ENOG4105C0H	protease
IM40_02155	ENOG4105D1H	recombination factor protein RarA
IM40_02180	ENOG4105EJC	lysr family transcriptional regulator
IM40_02370	ENOG4105K4U	addiction module toxin, RelE StbE family
IM40_02450	ENOG41090A4	Pterin carbinolamine dehydratase
IM40_02580	ENOG4105DUX	Transporter
IM40_02680	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
IM40_02805	ENOG4107YUR	Cell division protein mraZ
IM40_02810	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
IM40_02825	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
IM40_02830	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
IM40_02835	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
IM40_02840	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
IM40_02850	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
IM40_02855	ENOG4105DFU	Cell wall formation (By similarity)
IM40_02860	ENOG4105D4A	Cell wall formation (By similarity)
IM40_02865	ENOG4105CPF	Cell wall formation (By similarity)
IM40_02870	ENOG4108UFP	Essential cell division protein (By similarity)
IM40_02875	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
IM40_02900	ENOG4105D52	delta-aminolevulinic acid dehydratase
IM40_02920	ENOG4107G2R	Provides the rickettsial cell with host ATP in exchange for rickettsial ADP. This is an obligate exchange system. This energy acquiring activity is an important component of rickettsial parasitism
IM40_02930	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
IM40_02955	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
IM40_03010	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
IM40_03015	ENOG4105C9Q	fumarate hydratase class II
IM40_03025	ENOG4108Z6B	deaminase
IM40_03030	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
IM40_03035	ENOG4105D60	lipoprotein releasing system transmembrane protein
IM40_03040	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
IM40_03055	ENOG4105NWN	ApaG protein
IM40_03060	ENOG4107YD3	Thioesterase
IM40_03065	ENOG4105E02	MotA TolQ exbB proton channel
IM40_03095	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
IM40_03100	ENOG4105KCK	Peptidoglycan-associated lipoprotein
IM40_03105	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
IM40_03110	ENOG4105C22	threonyL-tRNA synthetase
IM40_03130	ENOG4105CP7	Triose-phosphate isomerase
IM40_03145	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
IM40_03150	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
IM40_03180	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
IM40_03185	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
IM40_03190	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
IM40_03250	ENOG4105DHP	deoxycytidine triphosphate deaminase
IM40_03270	ENOG4105C7I	Dehydrogenase
IM40_03275	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
IM40_03295	ENOG4105XA0	heptosyltransferase ii
IM40_03320	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
IM40_03325	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
IM40_03335	ENOG4107XYW	BioY family
IM40_03350	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
IM40_03355	ENOG4105K46	50S ribosomal protein l27
IM40_03390	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
IM40_03395	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
IM40_03400	ENOG4105CN1	protease
IM40_03405	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
IM40_03410	ENOG4107XZX	Involved in the transcription termination process (By similarity)
IM40_03425	ENOG4105D3R	alkyl hydroperoxide reductase
IM40_03435	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
IM40_03440	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
IM40_03445	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
IM40_03525	ENOG4105C4R	Atp-dependent dna helicase
IM40_03585	ENOG4105GR3	Histidine kinase
IM40_03610	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
IM40_03630	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
IM40_03635	ENOG4105C0B	DNA polymerase III (alpha subunit)
IM40_03640	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
IM40_03650	ENOG4108RG0	uracil-dna glycosylase
IM40_03655	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
IM40_03670	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
IM40_03675	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
IM40_03680	ENOG4106SNF	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM40_03685	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IM40_03700	ENOG4105VFU	Rna-binding protein
IM40_03740	ENOG4105WG9	Conserved Protein
IM40_03890	ENOG410642W	LysR family Transcriptional regulator
IM40_03925	ENOG4108UQS	dipeptidase
IM40_03960	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
IM40_04030	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
IM40_04035	ENOG4105C8N	cysteinyl-tRNA synthetase
IM40_04045	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
IM40_04055	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
IM40_04060	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
IM40_04075	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
IM40_04080	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
IM40_04100	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
IM40_04110	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
IM40_04115	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
IM40_04120	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
IM40_04125	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IM40_04130	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
IM40_04165	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
IM40_04180	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
IM40_04185	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
IM40_04190	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
IM40_04195	ENOG4107104	thymidine kinase
IM40_04215	ENOG4105D8X	mechanosensitive ion channel
IM40_04220	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
IM40_04250	ENOG4105EKQ	RNA-directed DNA polymerase
IM40_04275	ENOG4105K5G	30S ribosomal protein S21
IM40_04290	ENOG4105CEN	a g-specific adenine glycosylase
IM40_04300	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
IM40_04320	ENOG4107QX8	SPFH domain, Band 7 family protein
IM40_04325	ENOG4105DIT	ErfK YbiS YcfS YnhG family protein
IM40_04345	ENOG4108T5G	Adenylate
IM40_04355	ENOG4105ETT	transcriptional Regulator, LysR family
IM40_04365	ENOG4105D38	putrescine abc transporter
IM40_04370	ENOG4105F38	ABC transporter, permease
IM40_04375	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
IM40_04380	ENOG4105E5M	Multidrug resistance protein D
IM40_04385	ENOG4108JJ7	ABC transporter
IM40_04390	ENOG4107RTZ	reductase
IM40_04405	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
IM40_04410	ENOG4107ZJC	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
IM40_04415	ENOG410856B	UPF0235 protein
IM40_04430	ENOG4105FAV	ABC, transporter
IM40_04435	ENOG4105FDK	ABC transporter
IM40_04440	ENOG4107UKG	Glycosyl transferase, family 4
IM40_04455	ENOG4105CAT	Cytidine monophosphate kinase
IM40_04470	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
IM40_04525	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
IM40_04530	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
IM40_04540	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
IM40_04545	ENOG4105CE9	30S ribosomal protein S2
IM40_04555	ENOG4105EN6	Membrane
IM40_04570	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
IM40_04575	ENOG4105FYV	Amp nucleosidase
IM40_04580	ENOG4108EUD	Lysophospholipase
IM40_04585	ENOG4105D5T	phosphonate abc transporter
IM40_04605	ENOG4105ZIE	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)
IM40_04610	ENOG4105C9M	aspartyl-trna synthetase
IM40_04615	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
IM40_04620	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
IM40_04625	ENOG4105CUT	histidyl-tRNA synthetase
IM40_04650	ENOG4105DHJ	ABC, transporter
IM40_04660	ENOG4105E96	Colicin v production protein
IM40_04690	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
IM40_04695	ENOG4105W8H	transhydrogenase (subunit alpha
IM40_04700	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
IM40_04705	ENOG4105EIN	peptidylprolyl cis-trans isomerase
IM40_04755	ENOG4105BZ1	(ABC) transporter
IM40_04770	ENOG4105CAQ	asparagine synthetase
IM40_04775	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
IM40_04785	ENOG4107RCQ	(CBS) domain
IM40_04790	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
IM40_04795	ENOG4105C9A	Phoh family
IM40_04800	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
IM40_04810	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
IM40_04815	ENOG41072GX	Peptidase M22 Glycoprotease
IM40_04840	ENOG4105CNE	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
IM40_04845	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
IM40_04850	ENOG4105X17	23-dihydro-2,3-dihydroxybenzoate dehydrogenase
IM40_04855	ENOG4106H78	methyltransferase
IM40_04890	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
IM40_04900	ENOG4105KDC	50s ribosomal protein l28
IM40_04915	ENOG4105EAQ	(twin-arginine translocation) pathway signal
IM40_04925	ENOG4108HW3	(ABC) transporter
IM40_04935	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
IM40_04970	ENOG41082BR	50S ribosomal protein L35
IM40_04975	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
IM40_04990	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
IM40_04995	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
IM40_05000	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
IM40_05055	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
IM40_05075	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
IM40_05080	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
IM40_05085	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
IM40_05090	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
IM40_05095	ENOG4107ZDE	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
IM40_05105	ENOG4108594	Permease of the drug metabolite transporter
IM40_05115	ENOG4105K63	Thioredoxin
IM40_05125	ENOG4105BZU	Histidine kinase
IM40_05130	ENOG4105DC7	peptidase M24
IM40_05155	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
IM40_05170	ENOG4105VMP	Transcriptional regulator
IM40_05195	ENOG4105CDA	abc transporter atp-binding protein
IM40_05200	ENOG4105E5Q	amino acid AbC transporter
IM40_05220	ENOG4107RE3	peptidase, S41
IM40_05230	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
IM40_05235	ENOG4105F8V	Hydrolase, tatD family
IM40_05245	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
IM40_05250	ENOG4105DZ1	carboxypeptidase
IM40_05260	ENOG41080C8	DUF218 domain
IM40_05270	ENOG4105PW4	Sugar fermentation stimulation protein homolog
IM40_05275	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
IM40_05285	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
IM40_05290	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
IM40_05295	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM40_05300	ENOG4105C8S	subunit m
IM40_05310	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM40_05315	ENOG4105DF2	NADH dehydrogenase subunit j
IM40_05330	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
IM40_05350	ENOG4105C7S	Dehydrogenase
IM40_05360	ENOG4108JYK	Dehydrogenase
IM40_05365	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
IM40_05370	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
IM40_05380	ENOG4105K5M	30s ribosomal protein S16
IM40_05400	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
IM40_05405	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
IM40_05415	ENOG4105CI3	gtp-binding protein typa
IM40_05450	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
IM40_05455	ENOG4107ZGG	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
IM40_05470	ENOG4108EQH	DNA internalization-related competence protein ComEC Rec2
IM40_05475	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
IM40_05490	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
IM40_05530	ENOG4105C3G	gtp-binding protein
IM40_05535	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
IM40_05540	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
IM40_05565	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
IM40_05570	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
IM40_05595	ENOG4105C1V	Peptidase, M16
IM40_05615	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
IM40_05620	ENOG4105D48	metallophosphoesterase
IM40_05640	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
IM40_05650	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IM40_05660	ENOG4105EPW	hflc protein
IM40_05670	ENOG4105DHZ	alpha beta
IM40_05690	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
IM40_05695	ENOG4105C3J	Cysteine desulfurase
IM40_05700	ENOG4105C3J	Cysteine desulfurase
IM40_05705	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
IM40_05710	ENOG4108Z4V	iron-sulfur cluster assembly
IM40_05720	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
IM40_05750	ENOG4105C6K	Malic enzyme
IM40_05755	ENOG4105CJW	magnesium transporter
IM40_05760	ENOG4105CHU	acetyl-coa acetyltransferase
IM40_05790	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
IM40_05830	ENOG4105CMM	transposase
IM40_05850	ENOG4105BZU	Histidine kinase
IM40_05855	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_05895	ENOG4105DUX	Transporter
IM40_05905	ENOG4105HEI	LysR family (Transcriptional regulator
IM40_05950	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
IM40_05955	ENOG4105C1A	potassium transporter peripheral membrane
IM40_05990	ENOG4105W4M	Transport-associated protein
IM40_06005	ENOG4105MP9	class II Aldolase
IM40_06135	ENOG4107SC1	transglycosylase
IM40_06140	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
IM40_06145	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
IM40_06160	ENOG4105K3G	Periplasmic Protein
IM40_06170	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
IM40_06175	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
IM40_06210	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IM40_06215	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
IM40_06220	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
IM40_06230	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
IM40_06235	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
IM40_06240	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
IM40_06255	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
IM40_06275	ENOG4105MJ2	Competence protein
IM40_06280	ENOG4105VW4	glutaredoxin 3
IM40_06285	ENOG4105K70	DNA-binding protein
IM40_06300	ENOG4108Z1B	Cyclase dehydrase
IM40_06305	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
IM40_06315	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
IM40_06325	ENOG4105D6S	protein involved in catabolism of external DNA
IM40_06355	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
IM40_06365	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
IM40_06370	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
IM40_06375	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
IM40_06380	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
IM40_06490	ENOG4105EGI	Transcriptional regulator
IM40_06510	ENOG4105PUF	Ferredoxin, 2FE-2S
IM40_06540	ENOG4105C2N	RNA methyltransferase TrmH family group 3
IM40_06620	ENOG4105CSM	endonuclease III
IM40_06635	ENOG4105EFQ	Two component transcriptional regulator (Winged helix family
IM40_06640	ENOG4105E7T	carrier protein
IM40_06655	ENOG4105CA9	Pyruvate kinase
IM40_06660	ENOG4108PCN	EamA-like transporter family
IM40_06665	ENOG41089BK	Glutamine amido-transferase
IM40_06670	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
IM40_06685	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
IM40_06715	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
IM40_06720	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
IM40_06725	ENOG4105CDY	transcriptional regulatory protein
IM40_06770	ENOG4105P0T	Usg family
IM40_06780	ENOG4105EIX	cytochrome c1
IM40_06785	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
IM40_06790	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
IM40_06810	ENOG4105EGI	Transcriptional regulator
IM40_06825	ENOG41090FM	Phosphatase
IM40_06835	ENOG41090FM	Phosphatase
IM40_06875	ENOG41083MR	nifu domain-containing protein
IM40_06885	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
IM40_06890	ENOG4105BZJ	Electron transfer flavoprotein
IM40_06895	ENOG4105C10	Electron transfer flavoprotein
IM40_06915	ENOG41083BM	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
IM40_06935	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
IM40_06940	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
IM40_06945	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
IM40_06955	ENOG4108E87	P-loop hydrolase UPF0079
IM40_06960	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
IM40_06965	ENOG4105C31	Tryptophanyl-tRNA synthetase
IM40_06980	ENOG4105CJR	Integral membrane protein (MviN
IM40_07020	ENOG4105DFI	Membrane
IM40_07050	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
IM40_07055	ENOG4105D0A	hydroxylase
IM40_07060	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
IM40_07075	ENOG4105CAY	ferredoxin--nadp reductase
IM40_07085	ENOG4105BZA	Phosphoglycerate kinase
IM40_07100	ENOG4105DSE	periplasmic solute binding protein
IM40_07105	ENOG4105CC5	ABC transporter
IM40_07120	ENOG4105CAK	Cell division ATP-binding protein ftsE
IM40_07140	ENOG4105E9Q	Acyl-transferase
IM40_07155	ENOG4108V1U	phospholipid-binding protein
IM40_07165	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
IM40_07170	ENOG4105CFH	Aspartokinase
IM40_07190	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
IM40_07195	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
IM40_07210	ENOG4107QN2	dihydrolipoyl dehydrogenase
IM40_07215	ENOG4105C7S	Dehydrogenase
IM40_07220	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
IM40_07230	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
IM40_07235	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
IM40_07240	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
IM40_07260	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IM40_07265	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM40_07270	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IM40_07275	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM40_07285	ENOG4107QIZ	NADH dehydrogenase
IM40_07295	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
IM40_07300	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
IM40_07305	ENOG4105C57	major facilitator superfamily
IM40_07410	ENOG4105BZS	acriflavin resistance protein
IM40_07425	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
IM40_07440	ENOG4107ZQN	disulfide bond
IM40_07470	ENOG4105C75	arginyL-tRNA synthetase
IM40_07510	ENOG4105CRK	lysyL-tRNA synthetase
IM40_07520	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
IM40_07530	ENOG4105DCF	alanine dehydrogenase
IM40_07565	ENOG4108RVA	ribokinase
IM40_07575	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
IM40_07585	ENOG4108JU6	CBS domain protein
IM40_07595	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
IM40_07615	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
IM40_07620	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
IM40_07640	ENOG4108Z4T	Peptidase M50
IM40_07650	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
IM40_07655	ENOG4105CGK	Exodeoxyribonuclease III
IM40_07660	ENOG4108I0Z	Aconitate hydratase
IM40_07675	ENOG4108SXK	Transporter Drug Metabolite Exporter family
IM40_07695	ENOG4105DZP	Membrane-associated zinc metalloprotease
IM40_07700	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM40_07710	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IM40_07715	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
IM40_07720	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IM40_07725	ENOG4105GYT	Protein of unknown function (DUF1009)
IM40_07730	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
IM40_07735	ENOG4105DU1	integral membrane protein, terc
IM40_07765	ENOG4105C3M	thioredoxin reductase
IM40_07790	ENOG4105CNI	cell division protein FtsW
IM40_07815	ENOG4105DWF	phosphomethylpyrimidine kinase
IM40_08155	ENOG4108RAV	Conserved protein
IM40_08185	ENOG4107RSM	transcriptional regulator
IM40_08215	ENOG4105C7H	Helicase, RecD TraA family
IM40_08345	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_08360	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_08395	ENOG4107YBY	Hydrolase
IM40_08405	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
IM40_08460	ENOG4105N82	Endonuclease
IM40_08485	ENOG4108RAV	Conserved protein
IM40_08565	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_08595	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
IM40_08610	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
IM40_08615	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
IM40_08630	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
IM40_08640	ENOG4105DJV	ribulose-phosphate 3-epimerase
IM40_08650	ENOG4105CZQ	inner membrane transport protein YdhC
IM40_08660	ENOG4105CHM	Aminotransferase
IM40_08670	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
IM40_08685	ENOG4105BZ1	(ABC) transporter
IM40_08725	ENOG4107UIS	Involved in DNA repair and RecF pathway recombination (By similarity)
IM40_08730	ENOG4105EJC	lysr family transcriptional regulator
IM40_08735	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
IM40_08750	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
IM40_08755	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
IM40_08815	ENOG4105C0X	amino acid
IM40_08880	ENOG4108Z4U	Ferredoxin
IM40_08885	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
IM40_08895	ENOG4105ECY	inositol monophosphatase
IM40_08900	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
IM40_08925	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
IM40_08950	ENOG4108Z86	Glutamine amidotransferase
IM40_08965	ENOG4105TXM	Domain of unknown function (DUF3576)
IM40_08970	ENOG4105C8T	Leucyl-tRNA synthetase
IM40_08980	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
IM40_08985	ENOG4105DIJ	Phosphoethanolamine transferase
IM40_08990	ENOG41080IJ	Diacylglycerol kinase
IM40_09005	ENOG4105FA0	parb-like partition protein
IM40_09010	ENOG4107QJE	Chromosome Partitioning Protein
IM40_09015	ENOG4107YTN	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity)
IM40_09025	ENOG4108YXA	Membrane
IM40_09030	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
IM40_09035	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
IM40_09050	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
IM40_09060	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
IM40_09090	ENOG4107R11	Transcriptional regulator
IM40_09100	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
IM40_09105	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
IM40_09110	ENOG4105K59	histidine triad (HIT) protein
IM40_09120	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
IM40_09155	ENOG41082FP	UPF0102 protein
IM40_09165	ENOG4105D7Z	glutathione synthase
IM40_09175	ENOG4105C0P	Mg chelatase subunit ChlI
IM40_09185	ENOG410612Q	succinate dehydrogenase (cytochrome b-556 subunit)
IM40_09195	ENOG4108J01	L-aspartate oxidase
IM40_09210	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
IM40_09265	ENOG4105CMA	conjugation trbi family protein
IM40_09275	ENOG4108EHY	type IV secretion system
IM40_09340	ENOG4105KT5	UmuD protein
IM40_09345	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
IM40_09365	ENOG4105DFS	Conserved Protein
IM40_09375	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
IM40_09425	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
IM40_09440	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_09455	ENOG4108ZQS	transposase
IM40_09520	ENOG4105DQ6	Transposase
IM40_09620	ENOG4105DFS	Conserved Protein
IM40_09690	ENOG410600T	transposase
IM40_09755	ENOG4105EKQ	RNA-directed DNA polymerase
IM40_09765	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_09890	ENOG4105CC0	LysR family Transcriptional regulator
IM40_09990	ENOG4107QJE	Chromosome Partitioning Protein
IM40_10025	ENOG4105HEI	LysR family (Transcriptional regulator
IM40_10085	ENOG4105CMA	conjugation trbi family protein
IM40_10175	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
IM40_10180	ENOG4105KT5	UmuD protein
IM40_10200	ENOG4105WH1	Two component transcriptional regulator luxr family
IM40_10305	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_10360	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_10395	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
IM40_10435	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
IM40_10715	ENOG4105WH1	Two component transcriptional regulator luxr family
IM40_10730	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_10760	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
IM40_10800	ENOG4108CHM	Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases
IM40_10845	ENOG4105C7H	Helicase, RecD TraA family
IM40_10975	ENOG4105KT5	UmuD protein
IM40_11010	ENOG4105VDM	plasmid maintenance system antidote protein, xre family
IM40_11095	ENOG4105WG9	Conserved Protein
IM40_11140	ENOG4105BZU	Histidine kinase
IM40_11170	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_11180	ENOG4105EKQ	RNA-directed DNA polymerase
IM40_11195	ENOG4108EHY	type IV secretion system
IM40_11205	ENOG4105CMA	conjugation trbi family protein
IM40_11310	ENOG4108Q9H	CobQ/CobB/MinD/ParA nucleotide binding domain
IM40_11320	ENOG4105K70	DNA-binding protein
IM40_11375	ENOG41060JE	PilT protein domain protein
IM40_11440	ENOG4105EQR	Transposase IS116 IS110 IS902
IM40_11450	ENOG4108A32	Transposase