locus-tag	class	description
A1sIA105_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A1sIA105_00010	COG0592	DNA-directed DNA polymerase activity
A1sIA105_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A1sIA105_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
A1sIA105_00025	COG0443	Heat shock 70 kDa protein
A1sIA105_00030	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A1sIA105_00035	COG0484	heat shock protein binding
A1sIA105_00040	COG0789	Transcriptional regulator
A1sIA105_00055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A1sIA105_00065	COG1621	beta-fructofuranosidase activity
A1sIA105_00085	COG1609	Transcriptional regulator
A1sIA105_00090	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
A1sIA105_00095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1sIA105_00095	COG1754	DNA topoisomerase type I activity
A1sIA105_00115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A1sIA105_00120	COG0470	DNA polymerase III
A1sIA105_00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1sIA105_00170	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_00195	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_00200	COG1132	(ABC) transporter
A1sIA105_00205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1sIA105_00215	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A1sIA105_00225	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A1sIA105_00270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A1sIA105_00275	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A1sIA105_00280	COG1088	dTDP-glucose 4,6-dehydratase activity
A1sIA105_00285	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A1sIA105_00300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A1sIA105_00310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A1sIA105_00330	COG0456	acetyltransferase
A1sIA105_00335	COG0745	RESPONSE REGULATOR receiver
A1sIA105_00350	COG0735	belongs to the Fur family
A1sIA105_00360	COG4044	May play a role in the intracellular transport of hydrophobic ligands
A1sIA105_00370	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_00380	COG0588	phosphoglycerate mutase activity
A1sIA105_00395	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A1sIA105_00395	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A1sIA105_00400	COG0215	cysteine-tRNA ligase activity
A1sIA105_00405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1sIA105_00430	COG1252	NADH dehydrogenase
A1sIA105_00435	COG0702	epimerase
A1sIA105_00445	COG0459	protein refolding
A1sIA105_00470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A1sIA105_00475	COG0259	pyridoxamine-phosphate oxidase activity
A1sIA105_00490	COG2897	thiosulfate sulfurtransferase activity
A1sIA105_00500	COG3300	MHYT domain
A1sIA105_00500	COG5001	Diguanylate cyclase
A1sIA105_00510	COG0513	Belongs to the DEAD box helicase family
A1sIA105_00515	COG0300	oxidoreductase activity
A1sIA105_00530	COG0788	formyltetrahydrofolate deformylase activity
A1sIA105_00535	COG2409	Drug exporters of the RND superfamily
A1sIA105_00555	COG1960	acyl-CoA dehydrogenase activity
A1sIA105_00560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A1sIA105_00590	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1sIA105_00595	COG0084	hydrolase, TatD family'
A1sIA105_00600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A1sIA105_00605	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A1sIA105_00620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A1sIA105_00625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A1sIA105_00630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A1sIA105_00635	COG0193	aminoacyl-tRNA hydrolase activity
A1sIA105_00640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A1sIA105_00660	COG0148	phosphopyruvate hydratase activity
A1sIA105_00690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A1sIA105_00700	COG2814	Major facilitator Superfamily
A1sIA105_00715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1sIA105_00735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A1sIA105_00745	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A1sIA105_00745	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A1sIA105_00750	COG1722	exodeoxyribonuclease VII activity
A1sIA105_00755	COG1570	exodeoxyribonuclease VII activity
A1sIA105_00760	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A1sIA105_00780	COG0012	GTP binding
A1sIA105_00795	COG0210	DNA helicase
A1sIA105_00800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
A1sIA105_00850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A1sIA105_00855	COG1615	UPF0182 protein
A1sIA105_00870	COG0483	inositol monophosphate 1-phosphatase activity
A1sIA105_00875	COG1162	GTPase activity
A1sIA105_00880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A1sIA105_00885	COG2135	peptidase activity
A1sIA105_00890	COG1595	DNA-templated transcription, initiation
A1sIA105_00920	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1sIA105_00920	COG0567	Dehydrogenase, E1 component
A1sIA105_00925	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_00975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A1sIA105_00980	COG2884	Cell division ATP-binding protein ftsE
A1sIA105_00985	COG2177	Part of the ABC transporter FtsEX involved in
A1sIA105_00990	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A1sIA105_01005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A1sIA105_01010	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A1sIA105_01015	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A1sIA105_01020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A1sIA105_01025	COG1741	Belongs to the pirin family
A1sIA105_01050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A1sIA105_01075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A1sIA105_01080	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A1sIA105_01085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A1sIA105_01135	COG0018	arginyl-trna synthetase
A1sIA105_01145	COG0460	homoserine dehydrogenase
A1sIA105_01150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A1sIA105_01155	COG0083	homoserine kinase activity
A1sIA105_01165	COG0254	rRNA binding
A1sIA105_01170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A1sIA105_01175	COG2890	protein-(glutamine-N5) methyltransferase activity
A1sIA105_01185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A1sIA105_01190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1sIA105_01205	COG0356	it plays a direct role in the translocation of protons across the membrane
A1sIA105_01210	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A1sIA105_01215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A1sIA105_01220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A1sIA105_01225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A1sIA105_01230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A1sIA105_01235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A1sIA105_01240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A1sIA105_01275	COG1131	(ABC) transporter
A1sIA105_01310	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A1sIA105_01345	COG0328	RNA-DNA hybrid ribonuclease activity
A1sIA105_01345	COG0406	alpha-ribazole phosphatase activity
A1sIA105_01350	COG0861	Integral membrane protein TerC family
A1sIA105_01375	COG0791	NLP P60 protein
A1sIA105_01410	COG2329	Antibiotic biosynthesis monooxygenase
A1sIA105_01415	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_01425	COG3254	rhamnose metabolic process
A1sIA105_01430	COG0346	lactoylglutathione lyase activity
A1sIA105_01435	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_01445	COG2124	cytochrome p450
A1sIA105_01450	COG3618	amidohydrolase
A1sIA105_01465	COG0456	acetyltransferase
A1sIA105_01475	COG1982	Orn Lys Arg decarboxylase major
A1sIA105_01490	COG0343	queuine tRNA-ribosyltransferase activity
A1sIA105_01495	COG3590	peptidase
A1sIA105_01515	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A1sIA105_01520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A1sIA105_01520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1sIA105_01525	COG0174	glutamine synthetase
A1sIA105_01535	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A1sIA105_01540	COG1381	Involved in DNA repair and RecF pathway recombination
A1sIA105_01545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A1sIA105_01560	COG2329	Antibiotic biosynthesis monooxygenase
A1sIA105_01565	COG0423	glycine-tRNA ligase activity
A1sIA105_01580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A1sIA105_01600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1sIA105_01620	COG2197	response regulator
A1sIA105_01625	COG0745	RESPONSE REGULATOR receiver
A1sIA105_01630	COG5002	protein histidine kinase activity
A1sIA105_01635	COG0704	Plays a role in the regulation of phosphate uptake
A1sIA105_01660	COG0673	inositol 2-dehydrogenase activity
A1sIA105_01670	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_01675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1sIA105_01685	COG1609	Transcriptional regulator
A1sIA105_01690	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_01700	COG1129	ABC transporter
A1sIA105_01705	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1sIA105_01735	COG1278	Cold shock
A1sIA105_01760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1sIA105_01765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A1sIA105_01780	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_01785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1sIA105_01785	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_01795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A1sIA105_01805	COG0482	sulfurtransferase activity
A1sIA105_01810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A1sIA105_01815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A1sIA105_01820	COG0799	negative regulation of ribosome biogenesis
A1sIA105_01825	COG0588	phosphoglycerate mutase activity
A1sIA105_01835	COG0495	leucyl-tRNA aminoacylation
A1sIA105_01845	COG0268	Binds directly to 16S ribosomal RNA
A1sIA105_01850	COG0481	GTPase activity
A1sIA105_01860	COG1420	regulation of RNA biosynthetic process
A1sIA105_01865	COG0484	heat shock protein binding
A1sIA105_01870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A1sIA105_01880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A1sIA105_01895	COG0179	Fumarylacetoacetate (FAA) hydrolase
A1sIA105_01900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A1sIA105_01915	COG0277	FAD linked oxidase domain protein
A1sIA105_01950	COG3046	protein related to deoxyribodipyrimidine photolyase
A1sIA105_01980	COG1129	ABC transporter
A1sIA105_01985	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1sIA105_01990	COG3254	rhamnose metabolic process
A1sIA105_02000	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_02005	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_02010	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_02020	COG0765	amino acid transport
A1sIA105_02025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A1sIA105_02035	COG1940	carbohydrate kinase activity
A1sIA105_02040	COG1063	alcohol dehydrogenase
A1sIA105_02055	COG0395	ABC-type sugar transport system, permease component
A1sIA105_02070	COG0673	inositol 2-dehydrogenase activity
A1sIA105_02075	COG1082	Xylose isomerase domain protein TIM barrel
A1sIA105_02140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A1sIA105_02175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A1sIA105_02180	COG1388	LysM domain
A1sIA105_02190	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A1sIA105_02195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1sIA105_02215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A1sIA105_02215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A1sIA105_02220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A1sIA105_02225	COG1063	alcohol dehydrogenase
A1sIA105_02245	COG0395	ABC-type sugar transport system, permease component
A1sIA105_02250	COG3842	ATPase activity
A1sIA105_02255	COG3842	ATPase activity
A1sIA105_02280	COG0574	Belongs to the PEP-utilizing enzyme family
A1sIA105_02280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1sIA105_02300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A1sIA105_02325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1sIA105_02330	COG1120	ATPase activity
A1sIA105_02350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A1sIA105_02355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A1sIA105_02370	COG0187	DNA topoisomerase II activity
A1sIA105_02380	COG0488	(ABC) transporter
A1sIA105_02390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1sIA105_02410	COG0335	large ribosomal subunit rRNA binding
A1sIA105_02415	COG0681	Belongs to the peptidase S26 family
A1sIA105_02420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A1sIA105_02430	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A1sIA105_02435	COG1968	undecaprenyl-diphosphatase activity
A1sIA105_02440	COG0697	spore germination
A1sIA105_02445	COG0657	acetylesterase activity
A1sIA105_02450	COG0205	6-phosphofructokinase activity
A1sIA105_02455	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A1sIA105_02460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A1sIA105_02465	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
A1sIA105_02475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A1sIA105_02480	COG2815	serine threonine protein kinase
A1sIA105_02480	COG0515	serine threonine protein kinase
A1sIA105_02525	COG1215	transferase activity, transferring glycosyl groups
A1sIA105_02565	COG2223	nitrite transmembrane transporter activity
A1sIA105_02570	COG0730	response to heat
A1sIA105_02585	COG0587	DNA-directed DNA polymerase activity
A1sIA105_02600	COG2001	Belongs to the MraZ family
A1sIA105_02605	COG0275	rRNA processing
A1sIA105_02615	COG0768	penicillin binding
A1sIA105_02620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A1sIA105_02625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A1sIA105_02630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1sIA105_02635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A1sIA105_02645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1sIA105_02650	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A1sIA105_02660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A1sIA105_02670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A1sIA105_02675	COG1799	cell septum assembly
A1sIA105_02685	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A1sIA105_02690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A1sIA105_02695	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A1sIA105_02710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A1sIA105_02720	COG0131	Imidazoleglycerol-phosphate dehydratase
A1sIA105_02730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A1sIA105_02735	COG0107	imidazoleglycerol-phosphate synthase activity
A1sIA105_02740	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A1sIA105_02745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A1sIA105_02750	COG0134	indole-3-glycerol-phosphate synthase activity
A1sIA105_02755	COG0133	tryptophan synthase activity
A1sIA105_02760	COG0159	tryptophan synthase activity
A1sIA105_02775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A1sIA105_02785	COG0067	glutamate synthase
A1sIA105_02785	COG0070	glutamate synthase
A1sIA105_02785	COG0069	glutamate synthase activity
A1sIA105_02825	COG0411	ABC transporter
A1sIA105_02835	COG2050	protein possibly involved in aromatic compounds catabolism
A1sIA105_02850	COG0237	dephospho-CoA kinase activity
A1sIA105_02855	COG0556	nucleotide-excision repair
A1sIA105_02860	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A1sIA105_02865	COG0322	excinuclease ABC activity
A1sIA105_02870	COG1660	Displays ATPase and GTPase activities
A1sIA105_02880	COG1481	regulation of sporulation
A1sIA105_02885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A1sIA105_02890	COG0126	phosphoglycerate kinase activity
A1sIA105_02900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1sIA105_02920	COG1612	heme a metabolic process
A1sIA105_02945	COG0396	ATPase activity
A1sIA105_02950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1sIA105_02960	COG2151	metal-sulfur cluster biosynthetic enzyme
A1sIA105_02965	COG1132	(ABC) transporter
A1sIA105_02985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A1sIA105_02990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A1sIA105_02995	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A1sIA105_03000	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A1sIA105_03005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1sIA105_03010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A1sIA105_03015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1sIA105_03015	COG0072	phenylalanine-tRNA ligase activity
A1sIA105_03020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A1sIA105_03025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A1sIA105_03030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1sIA105_03040	COG0165	Argininosuccinate lyase
A1sIA105_03045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A1sIA105_03085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A1sIA105_03090	COG0497	DNA recombination
A1sIA105_03095	COG0504	CTP synthase activity
A1sIA105_03115	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A1sIA105_03120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A1sIA105_03140	COG1160	GTP binding
A1sIA105_03145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A1sIA105_03150	COG0509	glycine decarboxylation via glycine cleavage system
A1sIA105_03175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A1sIA105_03175	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A1sIA105_03180	COG0463	Glycosyl transferase, family 2
A1sIA105_03185	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A1sIA105_03190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A1sIA105_03205	COG0805	protein transport
A1sIA105_03215	COG2378	regulation of single-species biofilm formation
A1sIA105_03235	COG1410	methionine synthase
A1sIA105_03235	COG0646	methionine synthase
A1sIA105_03245	COG0215	cysteine-tRNA ligase activity
A1sIA105_03265	COG0667	Aldo Keto reductase
A1sIA105_03270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1sIA105_03280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A1sIA105_03285	COG1435	thymidine kinase activity
A1sIA105_03290	COG1811	Na channel or pump
A1sIA105_03295	COG2364	Membrane
A1sIA105_03300	COG2252	PERMEase
A1sIA105_03305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A1sIA105_03310	COG1119	ATPase activity
A1sIA105_03315	COG3830	Belongs to the UPF0237 family
A1sIA105_03315	COG0560	Phosphoserine phosphatase
A1sIA105_03320	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A1sIA105_03325	COG0140	phosphoribosyl-ATP diphosphatase activity
A1sIA105_03330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A1sIA105_03340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A1sIA105_03345	COG0242	peptide deformylase activity
A1sIA105_03355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A1sIA105_03365	COG1758	RNA polymerase activity
A1sIA105_03370	COG0194	GDP metabolic process
A1sIA105_03375	COG0284	orotidine-5'-phosphate decarboxylase activity
A1sIA105_03385	COG0543	2 iron, 2 sulfur cluster binding
A1sIA105_03390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A1sIA105_03395	COG0505	Belongs to the CarA family
A1sIA105_03400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A1sIA105_03405	COG0540	Belongs to the ATCase OTCase family
A1sIA105_03410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A1sIA105_03420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A1sIA105_03425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A1sIA105_03430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A1sIA105_03440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A1sIA105_03445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A1sIA105_03455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A1sIA105_03465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A1sIA105_03470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A1sIA105_03480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A1sIA105_03485	COG0124	histidyl-tRNA synthetase
A1sIA105_03490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1sIA105_03495	COG1196	nuclear chromosome segregation
A1sIA105_03500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1sIA105_03505	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1sIA105_03510	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1sIA105_03515	COG2255	four-way junction helicase activity
A1sIA105_03520	COG0632	four-way junction helicase activity
A1sIA105_03525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A1sIA105_03530	COG0217	transcriptional regulatory protein
A1sIA105_03540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A1sIA105_03555	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_03560	COG1560	Kdo2-lipid A biosynthetic process
A1sIA105_03580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A1sIA105_03625	COG0697	spore germination
A1sIA105_03635	COG3938	Belongs to the proline racemase family
A1sIA105_03680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A1sIA105_03690	COG1845	cytochrome c oxidase, subunit III
A1sIA105_03695	COG2010	Cytochrome c
A1sIA105_03700	COG0723	plastoquinol--plastocyanin reductase activity
A1sIA105_03705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A1sIA105_03720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1sIA105_03725	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A1sIA105_03745	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A1sIA105_03755	COG0667	Aldo Keto reductase
A1sIA105_03770	COG3845	ABC transporter
A1sIA105_03780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A1sIA105_03785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A1sIA105_03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1sIA105_03795	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1sIA105_03800	COG1090	epimerase
A1sIA105_03805	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
A1sIA105_03810	COG2409	Drug exporters of the RND superfamily
A1sIA105_03815	COG0321	lipoyl(octanoyl) transferase activity
A1sIA105_03820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A1sIA105_03845	COG0174	glutamine synthetase
A1sIA105_03855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A1sIA105_03865	COG0300	oxidoreductase activity
A1sIA105_03870	COG1024	Enoyl-CoA hydratase
A1sIA105_03890	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A1sIA105_03900	COG1940	carbohydrate kinase activity
A1sIA105_03920	COG2197	response regulator
A1sIA105_03925	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_03930	COG0791	NLP P60 protein
A1sIA105_03950	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A1sIA105_03955	COG0672	)-iron permease
A1sIA105_03960	COG0183	Belongs to the thiolase family
A1sIA105_03965	COG1024	Enoyl-CoA hydratase
A1sIA105_03965	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1sIA105_03970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A1sIA105_03975	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A1sIA105_03980	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A1sIA105_03985	COG0569	domain protein
A1sIA105_04000	COG0756	dUTP diphosphatase activity
A1sIA105_04020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A1sIA105_04025	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A1sIA105_04030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A1sIA105_04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A1sIA105_04045	COG0336	Belongs to the RNA methyltransferase TrmD family
A1sIA105_04050	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A1sIA105_04055	COG1837	Belongs to the UPF0109 family
A1sIA105_04060	COG0228	four-way junction DNA binding
A1sIA105_04065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A1sIA105_04070	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A1sIA105_04095	COG0571	ribonuclease III activity
A1sIA105_04110	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A1sIA105_04115	COG0742	ribosomal rna small subunit methyltransferase
A1sIA105_04125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A1sIA105_04140	COG1181	Belongs to the D-alanine--D-alanine ligase family
A1sIA105_04145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A1sIA105_04155	COG0776	regulation of translation
A1sIA105_04160	COG0066	3-isopropylmalate dehydratase activity
A1sIA105_04165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A1sIA105_04175	COG2137	regulation of response to DNA damage stimulus
A1sIA105_04180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A1sIA105_04200	COG1396	sequence-specific DNA binding
A1sIA105_04205	COG1058	Belongs to the CinA family
A1sIA105_04205	COG1546	Belongs to the CinA family
A1sIA105_04215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A1sIA105_04225	COG1674	ftsk spoiiie
A1sIA105_04235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1sIA105_04240	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A1sIA105_04260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A1sIA105_04265	COG0612	Peptidase, M16
A1sIA105_04270	COG1185	polyribonucleotide nucleotidyltransferase activity
A1sIA105_04285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A1sIA105_04290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A1sIA105_04295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A1sIA105_04295	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A1sIA105_04305	COG0779	Required for maturation of 30S ribosomal subunits
A1sIA105_04315	COG0442	prolyl-tRNA aminoacylation
A1sIA105_04320	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A1sIA105_04325	COG0750	zinc metalloprotease
A1sIA105_04345	COG1176	ABC-type spermidine putrescine transport system, permease component I
A1sIA105_04350	COG3842	ATPase activity
A1sIA105_04360	COG1012	belongs to the aldehyde dehydrogenase family
A1sIA105_04370	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A1sIA105_04380	COG0233	cytoplasmic translational termination
A1sIA105_04385	COG0528	UMP kinase activity
A1sIA105_04390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A1sIA105_04395	COG0052	Belongs to the universal ribosomal protein uS2 family
A1sIA105_04400	COG4974	Belongs to the 'phage' integrase family
A1sIA105_04415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A1sIA105_04420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1sIA105_04425	COG0473	3-isopropylmalate dehydrogenase activity
A1sIA105_04430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A1sIA105_04435	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A1sIA105_04440	COG0440	acetolactate synthase activity
A1sIA105_04450	COG0129	dihydroxy-acid dehydratase activity
A1sIA105_04460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1sIA105_04465	COG0154	amidase activity
A1sIA105_04470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1sIA105_04475	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A1sIA105_04480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A1sIA105_04485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A1sIA105_04490	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A1sIA105_04495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A1sIA105_04500	COG1530	ribonuclease E activity
A1sIA105_04505	COG0772	Belongs to the SEDS family
A1sIA105_04510	COG0768	penicillin binding
A1sIA105_04525	COG1077	Cell shape determining protein MreB Mrl
A1sIA105_04530	COG0105	UTP biosynthetic process
A1sIA105_04540	COG0285	dihydrofolate synthase activity
A1sIA105_04545	COG0525	valine-tRNA ligase activity
A1sIA105_04550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A1sIA105_04560	COG0740	serine-type endopeptidase activity
A1sIA105_04565	COG0740	serine-type endopeptidase activity
A1sIA105_04570	COG0544	peptidyl-prolyl cis-trans isomerase activity
A1sIA105_04595	COG0698	ribose 5-phosphate isomerase
A1sIA105_04600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A1sIA105_04620	COG0668	transmembrane transport
A1sIA105_04635	COG0824	Thioesterase
A1sIA105_04655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A1sIA105_04680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A1sIA105_04695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A1sIA105_04710	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_04725	COG1129	ABC transporter
A1sIA105_04740	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A1sIA105_04745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1sIA105_04760	COG0366	Alpha amylase catalytic
A1sIA105_04770	COG0137	argininosuccinate synthase activity
A1sIA105_04780	COG5002	protein histidine kinase activity
A1sIA105_04785	COG0745	RESPONSE REGULATOR receiver
A1sIA105_04810	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A1sIA105_04850	COG0653	protein targeting
A1sIA105_04855	COG1040	competence protein
A1sIA105_04860	COG5002	protein histidine kinase activity
A1sIA105_04860	COG5000	phosphorelay sensor kinase activity
A1sIA105_04865	COG0745	RESPONSE REGULATOR receiver
A1sIA105_04870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A1sIA105_04875	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1sIA105_04910	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A1sIA105_04915	COG0215	cysteine-tRNA ligase activity
A1sIA105_04925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1sIA105_04945	COG0513	Belongs to the DEAD box helicase family
A1sIA105_04955	COG0613	PHP domain protein
A1sIA105_04965	COG2239	Acts as a magnesium transporter
A1sIA105_04980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1sIA105_04985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1sIA105_04995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A1sIA105_05015	COG1611	Belongs to the LOG family
A1sIA105_05020	COG2171	N-acyltransferase activity
A1sIA105_05045	COG1316	TRANSCRIPTIONal
A1sIA105_05050	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A1sIA105_05055	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A1sIA105_05070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A1sIA105_05080	COG0424	maF-like protein
A1sIA105_05085	COG4770	biotin carboxylase activity
A1sIA105_05095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1sIA105_05105	COG1012	belongs to the aldehyde dehydrogenase family
A1sIA105_05110	COG1012	belongs to the aldehyde dehydrogenase family
A1sIA105_05115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A1sIA105_05145	COG1744	ABC transporter substrate-binding protein PnrA-like
A1sIA105_05155	COG0180	Tryptophanyl-tRNA synthetase
A1sIA105_05160	COG1253	flavin adenine dinucleotide binding
A1sIA105_05190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A1sIA105_05195	COG0138	bifunctional purine biosynthesis protein purh
A1sIA105_05215	COG0045	succinate-CoA ligase (ADP-forming) activity
A1sIA105_05225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A1sIA105_05235	COG1024	Enoyl-CoA hydratase
A1sIA105_05240	COG2186	Transcriptional regulator
A1sIA105_05250	COG1024	Enoyl-CoA hydratase
A1sIA105_05255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A1sIA105_05265	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_05270	COG0800	Aldolase
A1sIA105_05290	COG1129	ABC transporter
A1sIA105_05300	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_05315	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_05325	COG0148	phosphopyruvate hydratase activity
A1sIA105_05330	COG0129	dihydroxy-acid dehydratase activity
A1sIA105_05335	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A1sIA105_05340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A1sIA105_05340	COG0519	Catalyzes the synthesis of GMP from XMP
A1sIA105_05345	COG0516	GMP reductase activity
A1sIA105_05370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A1sIA105_05375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A1sIA105_05380	COG0456	acetyltransferase
A1sIA105_05385	COG1214	PFAM Peptidase M22, glycoprotease
A1sIA105_05385	COG0456	acetyltransferase
A1sIA105_05390	COG0802	atpase or kinase
A1sIA105_05410	COG0559	Belongs to the binding-protein-dependent transport system permease family
A1sIA105_05420	COG0411	ABC transporter
A1sIA105_05425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1sIA105_05430	COG0736	holo-[acyl-carrier-protein] synthase activity
A1sIA105_05440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A1sIA105_05445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1sIA105_05450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A1sIA105_05455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A1sIA105_05460	COG0101	tRNA pseudouridine synthase activity
A1sIA105_05465	COG0203	ribosomal protein L17
A1sIA105_05470	COG0202	RNA polymerase activity
A1sIA105_05475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A1sIA105_05480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A1sIA105_05485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A1sIA105_05490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A1sIA105_05500	COG0563	adenylate kinase activity
A1sIA105_05510	COG0200	Binds to the 23S rRNA
A1sIA105_05515	COG1841	ribosomal large subunit assembly
A1sIA105_05520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A1sIA105_05530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A1sIA105_05535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A1sIA105_05540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A1sIA105_05545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A1sIA105_05550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A1sIA105_05555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A1sIA105_05560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A1sIA105_05565	COG0255	Belongs to the universal ribosomal protein uL29 family
A1sIA105_05570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A1sIA105_05575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A1sIA105_05580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A1sIA105_05585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A1sIA105_05595	COG0089	rRNA binding
A1sIA105_05600	COG0088	Forms part of the polypeptide exit tunnel
A1sIA105_05605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A1sIA105_05610	COG0051	transcription antitermination factor activity, RNA binding
A1sIA105_05615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A1sIA105_05620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A1sIA105_05625	COG0049	tRNA binding
A1sIA105_05630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A1sIA105_05645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A1sIA105_05650	COG0085	RNA polymerase activity
A1sIA105_05655	COG0222	ribosome binding
A1sIA105_05665	COG0081	regulation of translation
A1sIA105_05670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A1sIA105_05680	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1sIA105_05690	COG0436	Aminotransferase
A1sIA105_05695	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A1sIA105_05710	COG2030	dehydratase
A1sIA105_05715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A1sIA105_05735	COG1832	CoA-binding protein
A1sIA105_05740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A1sIA105_05755	COG1126	abc transporter atp-binding protein
A1sIA105_05760	COG0765	amino acid transport
A1sIA105_05775	COG1666	GTP binding
A1sIA105_05815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1sIA105_05820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A1sIA105_05825	COG1034	ATP synthesis coupled electron transport
A1sIA105_05830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A1sIA105_05840	COG0649	NAD binding
A1sIA105_05845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1sIA105_05860	COG2226	methyltransferase
A1sIA105_05865	COG1268	BioY protein
A1sIA105_05870	COG1169	isochorismate synthase
A1sIA105_05875	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A1sIA105_05880	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_05885	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A1sIA105_05905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1sIA105_05910	COG1333	cytochrome c biogenesis protein
A1sIA105_05915	COG0785	Cytochrome C biogenesis protein
A1sIA105_05920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1sIA105_05925	COG0406	alpha-ribazole phosphatase activity
A1sIA105_05930	COG0560	Phosphoserine phosphatase
A1sIA105_05945	COG1061	Type III restriction enzyme res subunit
A1sIA105_05965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A1sIA105_05975	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A1sIA105_05980	COG1194	a g-specific adenine glycosylase
A1sIA105_05985	COG0542	response to heat
A1sIA105_05990	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A1sIA105_05995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A1sIA105_06000	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A1sIA105_06010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A1sIA105_06015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A1sIA105_06020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A1sIA105_06030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A1sIA105_06035	COG0302	gtp cyclohydrolase
A1sIA105_06050	COG0037	tRNA processing
A1sIA105_06055	COG0791	NLP P60 protein
A1sIA105_06075	COG0109	protoheme IX farnesyltransferase activity
A1sIA105_06105	COG0310	cobalt ion transport
A1sIA105_06115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A1sIA105_06120	COG1122	ATPase activity
A1sIA105_06135	COG0009	L-threonylcarbamoyladenylate synthase
A1sIA105_06140	COG0438	transferase activity, transferring glycosyl groups
A1sIA105_06170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1sIA105_06205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A1sIA105_06210	COG0047	phosphoribosylformylglycinamidine synthase activity
A1sIA105_06215	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A1sIA105_06220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A1sIA105_06225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A1sIA105_06230	COG0151	Belongs to the GarS family
A1sIA105_06235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A1sIA105_06240	COG0191	fructose-bisphosphate aldolase activity
A1sIA105_06245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1sIA105_06255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A1sIA105_06270	COG0251	oxidation-reduction process
A1sIA105_06275	COG1610	YqeY-like protein
A1sIA105_06280	COG1408	metallophosphoesterase
A1sIA105_06285	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A1sIA105_06295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1sIA105_06310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A1sIA105_06355	COG0531	amino acid
A1sIA105_06360	COG0590	tRNA wobble adenosine to inosine editing
A1sIA105_06360	COG0037	tRNA processing
A1sIA105_06370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A1sIA105_06380	COG0586	Pfam SNARE associated Golgi protein
A1sIA105_06390	COG0488	(ABC) transporter
A1sIA105_06395	COG3844	kynureninase activity
A1sIA105_06400	COG3483	tryptophan 2,3-dioxygenase activity
A1sIA105_06405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1sIA105_06425	COG0175	sulfate reduction
A1sIA105_06435	COG0730	response to heat
A1sIA105_06440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A1sIA105_06455	COG0493	'glutamate synthase
A1sIA105_06465	COG3254	rhamnose metabolic process
A1sIA105_06475	COG3347	Dehydrogenase
A1sIA105_06475	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_06480	COG1070	Carbohydrate kinase
A1sIA105_06490	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_06495	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_06510	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_06515	COG1028	Short-chain dehydrogenase reductase Sdr
A1sIA105_06520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A1sIA105_06525	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1sIA105_06525	COG0022	dehydrogenase e1 component
A1sIA105_06530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A1sIA105_06535	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1sIA105_06540	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_06550	COG2160	L-arabinose isomerase activity
A1sIA105_06555	COG1172	Belongs to the binding-protein-dependent transport system permease family
A1sIA105_06560	COG1129	ABC transporter
A1sIA105_06570	COG4948	Mandelate Racemase Muconate Lactonizing
A1sIA105_06575	COG1609	Transcriptional regulator
A1sIA105_06585	COG0673	inositol 2-dehydrogenase activity
A1sIA105_06615	COG0006	proline dipeptidase activity
A1sIA105_06620	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A1sIA105_06625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A1sIA105_06635	COG1053	succinate dehydrogenase
A1sIA105_06650	COG0561	phosphatase activity
A1sIA105_06655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A1sIA105_06660	COG0077	Prephenate dehydratase
A1sIA105_06675	COG0515	serine threonine protein kinase
A1sIA105_06695	COG2181	nitrate reductase activity
A1sIA105_06695	COG0247	lactate metabolic process
A1sIA105_06700	COG0457	Tetratricopeptide repeat
A1sIA105_06700	COG0705	Rhomboid family
A1sIA105_06715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1sIA105_06720	COG0187	DNA topoisomerase II activity
A1sIA105_06725	COG0501	Belongs to the peptidase M48B family
A1sIA105_06730	COG1704	LemA family
A1sIA105_06735	COG0717	Belongs to the dCTP deaminase family
A1sIA105_06740	COG1960	acyl-CoA dehydrogenase activity
A1sIA105_06750	COG0305	Participates in initiation and elongation during chromosome replication
A1sIA105_06755	COG0598	Magnesium transport protein CorA
A1sIA105_06760	COG0359	binds to the 23S rRNA
A1sIA105_06765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A1sIA105_06775	COG0360	Binds together with S18 to 16S ribosomal RNA
A1sIA105_06785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1sIA105_06800	COG0617	tRNA 3'-terminal CCA addition
A1sIA105_06820	COG0492	ferredoxin-NADP+ reductase activity
A1sIA105_06825	COG3118	belongs to the thioredoxin family
A1sIA105_06830	COG0860	N-Acetylmuramoyl-L-alanine amidase
A1sIA105_06830	COG3409	Peptidoglycan-binding domain 1 protein
A1sIA105_06835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1sIA105_06845	COG1192	Involved in chromosome partitioning
A1sIA105_06850	COG0357	Ribosomal RNA small subunit methyltransferase G
A1sIA105_06860	COG0706	membrane insertase activity
A1sIA105_06865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A1sIA105_06875	COG0230	Belongs to the bacterial ribosomal protein bL34 family