locus-tag	class	description
Rmag_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Rmag_0002	COG0592	DNA-directed DNA polymerase activity
Rmag_0003	COG0187	DNA topoisomerase II activity
Rmag_0005	COG0495	leucyl-tRNA aminoacylation
Rmag_0006	COG0167	dihydroorotate dehydrogenase activity
Rmag_0007	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Rmag_0008	COG0625	glutathione transferase activity
Rmag_0009	COG2857	Cytochrome c1
Rmag_0010	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Rmag_0011	COG0723	plastoquinol--plastocyanin reductase activity
Rmag_0013	COG0653	protein targeting
Rmag_0014	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Rmag_0015	COG0418	dihydroorotase activity
Rmag_0016	COG0196	riboflavin kinase activity
Rmag_0018	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Rmag_0020	COG0436	Aminotransferase
Rmag_0023	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Rmag_0024	COG0739	heme binding
Rmag_0025	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Rmag_0026	COG0575	Belongs to the CDS family
Rmag_0028	COG0107	imidazoleglycerol-phosphate synthase activity
Rmag_0030	COG0109	protoheme IX farnesyltransferase activity
Rmag_0034	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Rmag_0035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Rmag_0037	COG1845	cytochrome c oxidase, subunit III
Rmag_0039	COG3278	Belongs to the heme-copper respiratory oxidase family
Rmag_0041	COG2010	Cytochrome c
Rmag_0043	COG1674	ftsk spoiiie
Rmag_0044	COG0492	ferredoxin-NADP+ reductase activity
Rmag_0045	COG0540	Belongs to the ATCase OTCase family
Rmag_0047	COG2951	lytic endotransglycosylase activity
Rmag_0048	COG1477	protein flavinylation
Rmag_0050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Rmag_0051	COG0189	ligase activity
Rmag_0052	COG0779	Required for maturation of 30S ribosomal subunits
Rmag_0053	COG0195	Participates in both transcription termination and antitermination
Rmag_0054	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Rmag_0055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Rmag_0056	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Rmag_0057	COG0151	Belongs to the GarS family
Rmag_0059	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Rmag_0061	COG0237	dephospho-CoA kinase activity
Rmag_0062	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Rmag_0063	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Rmag_0065	COG0126	phosphoglycerate kinase activity
Rmag_0066	COG0469	pyruvate kinase activity
Rmag_0068	COG0445	tRNA wobble uridine modification
Rmag_0069	COG0357	Ribosomal RNA small subunit methyltransferase G
Rmag_0071	COG0084	hydrolase, TatD family'
Rmag_0073	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Rmag_0074	COG2171	N-acyltransferase activity
Rmag_0079	COG0018	arginyl-trna synthetase
Rmag_0080	COG1074	ATP-dependent DNA helicase activity
Rmag_0082	COG0352	thiamine-phosphate diphosphorylase activity
Rmag_0085	COG2046	Belongs to the sulfate adenylyltransferase family
Rmag_0090	COG1047	Peptidyl-prolyl cis-trans
Rmag_0092	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Rmag_0093	COG0563	adenylate kinase activity
Rmag_0094	COG0205	6-phosphofructokinase activity
Rmag_0097	COG0215	cysteine-tRNA ligase activity
Rmag_0098	COG0450	alkyl hydroperoxide reductase
Rmag_0099	COG0473	3-isopropylmalate dehydrogenase activity
Rmag_0101	COG0494	nUDIX hydrolase
Rmag_0103	COG0019	diaminopimelate decarboxylase activity
Rmag_0105	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Rmag_0106	COG0157	Belongs to the NadC ModD family
Rmag_0108	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Rmag_0109	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Rmag_0110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Rmag_0111	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Rmag_0112	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Rmag_0113	COG0006	proline dipeptidase activity
Rmag_0117	COG0546	phosphoglycolate phosphatase activity
Rmag_0118	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Rmag_0120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Rmag_0121	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Rmag_0123	COG0825	malonyl-CoA metabolic process
Rmag_0124	COG1392	Phosphate transport regulator
Rmag_0125	COG0306	phosphate transporter
Rmag_0126	COG0271	Belongs to the BolA IbaG family
Rmag_0127	COG0513	Belongs to the DEAD box helicase family
Rmag_0129	COG1696	Membrane protein involved in D-alanine export
Rmag_0132	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Rmag_0133	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Rmag_0136	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Rmag_0137	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Rmag_0138	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Rmag_0139	COG4657	Part of a membrane complex involved in electron transport
Rmag_0140	COG2878	Part of a membrane complex involved in electron transport
Rmag_0142	COG4658	electron transport chain
Rmag_0143	COG4659	FMN binding
Rmag_0145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Rmag_0146	COG0045	succinate-CoA ligase (ADP-forming) activity
Rmag_0147	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Rmag_0148	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Rmag_0151	COG0137	argininosuccinate synthase activity
Rmag_0152	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Rmag_0153	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Rmag_0156	COG0737	Belongs to the 5'-nucleotidase family
Rmag_0158	COG0517	IMP dehydrogenase activity
Rmag_0158	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Rmag_0160	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Rmag_0161	COG0049	tRNA binding
Rmag_0162	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Rmag_0163	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Rmag_0164	COG0051	transcription antitermination factor activity, RNA binding
Rmag_0165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Rmag_0166	COG0088	Forms part of the polypeptide exit tunnel
Rmag_0167	COG0089	rRNA binding
Rmag_0168	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Rmag_0169	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Rmag_0170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Rmag_0171	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Rmag_0172	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Rmag_0173	COG0255	Belongs to the universal ribosomal protein uL29 family
Rmag_0174	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Rmag_0175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Rmag_0176	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Rmag_0177	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Rmag_0178	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Rmag_0179	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Rmag_0180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Rmag_0181	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Rmag_0182	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Rmag_0183	COG1841	ribosomal large subunit assembly
Rmag_0184	COG0200	Binds to the 23S rRNA
Rmag_0186	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Rmag_0187	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Rmag_0188	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Rmag_0189	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Rmag_0190	COG0202	RNA polymerase activity
Rmag_0191	COG0203	ribosomal protein L17
Rmag_0192	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Rmag_0196	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Rmag_0197	COG0617	tRNA 3'-terminal CCA addition
Rmag_0200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Rmag_0204	COG0544	peptidyl-prolyl cis-trans isomerase activity
Rmag_0205	COG0740	serine-type endopeptidase activity
Rmag_0206	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Rmag_0207	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Rmag_0208	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Rmag_0209	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Rmag_0209	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Rmag_0210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Rmag_0211	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Rmag_0220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Rmag_0222	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Rmag_0224	COG2210	Belongs to the sulfur carrier protein TusA family
Rmag_0225	COG0425	Belongs to the sulfur carrier protein TusA family
Rmag_0227	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Rmag_0228	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Rmag_0232	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Rmag_0233	COG0543	2 iron, 2 sulfur cluster binding
Rmag_0234	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Rmag_0236	COG0312	modulator of DNA gyrase
Rmag_0237	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Rmag_0238	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Rmag_0239	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Rmag_0240	COG0649	NAD binding
Rmag_0242	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Rmag_0243	COG1034	ATP synthesis coupled electron transport
Rmag_0244	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Rmag_0245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Rmag_0247	COG0713	ATP synthesis coupled electron transport
Rmag_0250	COG1007	ATP synthesis coupled electron transport
Rmag_0256	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Rmag_0257	COG2226	methyltransferase
Rmag_0259	COG0500	methyltransferase
Rmag_0261	COG0233	cytoplasmic translational termination
Rmag_0262	COG0528	UMP kinase activity
Rmag_0263	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Rmag_0265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Rmag_0266	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Rmag_0267	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Rmag_0268	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Rmag_0270	COG1648	precorrin-2 dehydrogenase activity
Rmag_0270	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Rmag_0271	COG0560	Phosphoserine phosphatase
Rmag_0272	COG1138	Cytochrome C-type biogenesis protein
Rmag_0274	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Rmag_0276	COG0347	Belongs to the P(II) protein family
Rmag_0277	COG0004	ammonium transporteR
Rmag_0278	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Rmag_0280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Rmag_0281	COG0347	Belongs to the P(II) protein family
Rmag_0283	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Rmag_0284	COG3707	response regulator
Rmag_0285	COG0805	protein transport
Rmag_0286	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Rmag_0287	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Rmag_0288	COG0140	phosphoribosyl-ATP diphosphatase activity
Rmag_0289	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Rmag_0293	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Rmag_0294	COG1560	Kdo2-lipid A biosynthetic process
Rmag_0298	COG0275	rRNA processing
Rmag_0302	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Rmag_0304	COG1469	GTP cyclohydrolase I activity
Rmag_0305	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Rmag_0309	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Rmag_0310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Rmag_0311	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Rmag_0312	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Rmag_0313	COG0277	FAD linked oxidase domain protein
Rmag_0314	COG0277	FAD linked oxidase domain protein
Rmag_0315	COG0247	lactate metabolic process
Rmag_0318	COG1472	Belongs to the glycosyl hydrolase 3 family
Rmag_0320	COG0210	DNA helicase
Rmag_0323	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Rmag_0327	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Rmag_0328	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Rmag_0329	COG0564	pseudouridine synthase activity
Rmag_0332	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Rmag_0336	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Rmag_0337	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Rmag_0338	COG0180	Tryptophanyl-tRNA synthetase
Rmag_0339	COG1187	pseudouridine synthase activity
Rmag_0340	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Rmag_0341	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Rmag_0343	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Rmag_0344	COG0154	amidase activity
Rmag_0345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Rmag_0347	COG1994	Peptidase M50
Rmag_0348	COG0442	prolyl-tRNA aminoacylation
Rmag_0349	COG0688	phosphatidylethanolamine metabolic process
Rmag_0350	COG4536	flavin adenine dinucleotide binding
Rmag_0351	COG0148	phosphopyruvate hydratase activity
Rmag_0352	COG0484	heat shock protein binding
Rmag_0353	COG0443	Heat shock 70 kDa protein
Rmag_0354	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Rmag_0355	COG0742	ribosomal rna small subunit methyltransferase
Rmag_0356	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Rmag_0361	COG5000	phosphorelay sensor kinase activity
Rmag_0362	COG4566	intracellular signal transduction
Rmag_0363	COG0569	domain protein
Rmag_0364	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Rmag_0365	COG1199	ATP-dependent helicase activity
Rmag_0366	COG0142	geranyltranstransferase activity
Rmag_0367	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Rmag_0371	COG0066	3-isopropylmalate dehydratase activity
Rmag_0372	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Rmag_0373	COG0367	asparagine synthase
Rmag_0374	COG0328	RNA-DNA hybrid ribonuclease activity
Rmag_0378	COG2867	negative regulation of translational initiation
Rmag_0379	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Rmag_0381	COG0105	UTP biosynthetic process
Rmag_0382	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Rmag_0384	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Rmag_0386	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Rmag_0388	COG2813	Specifically methylates the guanine in position
Rmag_0389	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Rmag_0392	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Rmag_0392	COG0047	phosphoribosylformylglycinamidine synthase activity
Rmag_0394	COG0217	transcriptional regulatory protein
Rmag_0396	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Rmag_0398	COG0024	Methionine aminopeptidase
Rmag_0399	COG0501	Belongs to the peptidase M48B family
Rmag_0400	COG1704	LemA family
Rmag_0404	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Rmag_0405	COG1758	RNA polymerase activity
Rmag_0410	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Rmag_0411	COG1519	Transferase
Rmag_0412	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Rmag_0413	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Rmag_0414	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Rmag_0415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Rmag_0416	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Rmag_0417	COG0316	Belongs to the HesB IscA family
Rmag_0417	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Rmag_0419	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Rmag_0420	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Rmag_0421	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Rmag_0426	COG0556	nucleotide-excision repair
Rmag_0427	COG0602	queuosine metabolic process
Rmag_0430	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Rmag_0432	COG0284	orotidine-5'-phosphate decarboxylase activity
Rmag_0434	COG0259	pyridoxamine-phosphate oxidase activity
Rmag_0435	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Rmag_0436	COG1530	ribonuclease E activity
Rmag_0437	COG0300	oxidoreductase activity
Rmag_0439	COG1968	undecaprenyl-diphosphatase activity
Rmag_0440	COG0308	aminopeptidase N
Rmag_0441	COG1058	Belongs to the CinA family
Rmag_0441	COG1546	Belongs to the CinA family
Rmag_0442	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Rmag_0444	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Rmag_0445	COG0028	Belongs to the TPP enzyme family
Rmag_0447	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Rmag_0448	COG1183	phosphatidylcholine synthase activity
Rmag_0449	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Rmag_0452	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Rmag_0453	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Rmag_0455	COG2239	Acts as a magnesium transporter
Rmag_0456	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Rmag_0461	COG1185	polyribonucleotide nucleotidyltransferase activity
Rmag_0462	COG0517	IMP dehydrogenase activity
Rmag_0462	COG0516	GMP reductase activity
Rmag_0466	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Rmag_0467	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Rmag_0470	COG1686	Belongs to the peptidase S11 family
Rmag_0471	COG0772	Belongs to the SEDS family
Rmag_0474	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Rmag_0476	COG3118	belongs to the thioredoxin family
Rmag_0479	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Rmag_0480	COG0617	tRNA 3'-terminal CCA addition
Rmag_0481	COG1722	exodeoxyribonuclease VII activity
Rmag_0482	COG0142	geranyltranstransferase activity
Rmag_0483	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Rmag_0484	COG0416	fatty acid biosynthetic process
Rmag_0485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Rmag_0489	COG1322	Protein conserved in bacteria
Rmag_0490	COG1028	Short-chain dehydrogenase reductase Sdr
Rmag_0493	COG0326	Molecular chaperone. Has ATPase activity
Rmag_0496	COG0408	coproporphyrinogen oxidase activity
Rmag_0498	COG0174	glutamine synthetase
Rmag_0499	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Rmag_0500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Rmag_0501	COG0772	Belongs to the SEDS family
Rmag_0502	COG0488	(ABC) transporter
Rmag_0506	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Rmag_0507	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Rmag_0509	COG0537	adenosine 5'-monophosphoramidase activity
Rmag_0510	COG0629	single-stranded DNA binding
Rmag_0511	COG2814	Major facilitator Superfamily
Rmag_0513	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Rmag_0515	COG0823	Involved in the tonB-independent uptake of proteins
Rmag_0516	COG2885	chlorophyll binding
Rmag_0518	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Rmag_0519	COG2095	MarC family integral membrane protein
Rmag_0520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Rmag_0520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Rmag_0522	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Rmag_0523	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Rmag_0524	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Rmag_0529	COG0129	dihydroxy-acid dehydratase activity
Rmag_0530	COG0557	exoribonuclease II activity
Rmag_0531	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Rmag_0532	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Rmag_0533	COG0330	HflC and HflK could
Rmag_0534	COG0330	HflC and HflK could
Rmag_0535	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Rmag_0537	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Rmag_0541	COG2921	Belongs to the UPF0250 family
Rmag_0542	COG0321	lipoyl(octanoyl) transferase activity
Rmag_0543	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Rmag_0546	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Rmag_0547	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Rmag_0548	COG2967	ApaG domain
Rmag_0549	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Rmag_0550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Rmag_0552	COG0750	zinc metalloprotease
Rmag_0554	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Rmag_0555	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Rmag_0556	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Rmag_0557	COG0728	peptidoglycan biosynthetic process
Rmag_0558	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Rmag_0560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Rmag_0561	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Rmag_0562	COG0459	protein refolding
Rmag_0564	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Rmag_0565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Rmag_0566	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Rmag_0568	COG0339	signal peptide processing
Rmag_0570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Rmag_0571	COG0489	protein tyrosine kinase activity
Rmag_0573	COG0443	Heat shock 70 kDa protein
Rmag_0574	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Rmag_0576	COG0822	iron-sulfur transferase activity
Rmag_0577	COG1104	cysteine desulfurase activity
Rmag_0581	COG0037	tRNA processing
Rmag_0583	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Rmag_0585	COG0527	aspartate kinase activity
Rmag_0587	COG0501	Belongs to the peptidase M48B family
Rmag_0589	COG1162	GTPase activity
Rmag_0590	COG2363	Small membrane protein
Rmag_0591	COG0776	regulation of translation
Rmag_0593	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Rmag_0594	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Rmag_0595	COG3088	subunit of a heme lyase
Rmag_0597	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Rmag_0597	COG0546	phosphoglycolate phosphatase activity
Rmag_0598	COG0322	excinuclease ABC activity
Rmag_0600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Rmag_0601	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Rmag_0602	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Rmag_0604	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Rmag_0606	COG0481	GTPase activity
Rmag_0607	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Rmag_0608	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Rmag_0610	COG0736	holo-[acyl-carrier-protein] synthase activity
Rmag_0611	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Rmag_0614	COG0571	ribonuclease III activity
Rmag_0616	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Rmag_0617	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Rmag_0620	COG0793	Belongs to the peptidase S41A family
Rmag_0621	COG0681	Belongs to the peptidase S26 family
Rmag_0622	COG2920	part of a sulfur-relay system
Rmag_0623	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Rmag_0624	COG0287	Prephenate dehydrogenase
Rmag_0625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Rmag_0626	COG0077	Prephenate dehydratase
Rmag_0626	COG1605	Chorismate mutase
Rmag_0627	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Rmag_0628	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Rmag_0631	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Rmag_0632	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Rmag_0635	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Rmag_0636	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Rmag_0639	COG0628	permease
Rmag_0641	COG0776	regulation of translation
Rmag_0643	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Rmag_0645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Rmag_0646	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Rmag_0647	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Rmag_0648	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Rmag_0651	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Rmag_0652	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Rmag_0654	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Rmag_0656	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Rmag_0659	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Rmag_0662	COG1214	PFAM Peptidase M22, glycoprotease
Rmag_0663	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Rmag_0664	COG0360	Binds together with S18 to 16S ribosomal RNA
Rmag_0665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Rmag_0666	COG0359	binds to the 23S rRNA
Rmag_0668	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Rmag_0669	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Rmag_0671	COG0124	histidyl-tRNA synthetase
Rmag_0673	COG1160	GTP binding
Rmag_0674	COG0504	CTP synthase activity
Rmag_0676	COG1132	(ABC) transporter
Rmag_0677	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Rmag_0684	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Rmag_0685	COG0243	molybdopterin cofactor binding
Rmag_0686	COG2815	serine threonine protein kinase
Rmag_0686	COG0515	serine threonine protein kinase
Rmag_0687	COG2223	nitrite transmembrane transporter activity
Rmag_0688	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Rmag_0689	COG0314	molybdopterin synthase activity
Rmag_0690	COG0746	molybdenum cofactor guanylyltransferase activity
Rmag_0691	COG0303	'Molybdopterin
Rmag_0692	COG0315	cyclic pyranopterin monophosphate synthase activity
Rmag_0693	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Rmag_0698	COG0521	Mo-molybdopterin cofactor biosynthetic process
Rmag_0701	COG1850	ribulose-bisphosphate carboxylase activity
Rmag_0704	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Rmag_0707	COG3842	ATPase activity
Rmag_0708	COG2132	Multicopper oxidase
Rmag_0714	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Rmag_0716	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Rmag_0717	COG1393	Belongs to the ArsC family
Rmag_0721	COG0751	glycine-tRNA ligase activity
Rmag_0725	COG0811	peptide transport
Rmag_0730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Rmag_0731	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Rmag_0732	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Rmag_0733	COG0735	belongs to the Fur family
Rmag_0734	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Rmag_0736	COG4133	protoheme IX ABC transporter activity
Rmag_0737	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Rmag_0738	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Rmag_0739	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Rmag_0741	COG1238	metal cluster binding
Rmag_0742	COG0668	transmembrane transport
Rmag_0743	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Rmag_0747	COG0482	sulfurtransferase activity
Rmag_0748	COG2915	High frequency lysogenization protein hflD homolog
Rmag_0749	COG0268	Binds directly to 16S ribosomal RNA
Rmag_0750	COG1570	exodeoxyribonuclease VII activity
Rmag_0751	COG0739	heme binding
Rmag_0755	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Rmag_0756	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Rmag_0757	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Rmag_0759	COG1181	Belongs to the D-alanine--D-alanine ligase family
Rmag_0762	COG0741	lytic transglycosylase activity
Rmag_0762	COG1388	LysM domain
Rmag_0763	COG0271	Belongs to the BolA IbaG family
Rmag_0764	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Rmag_0764	COG0543	2 iron, 2 sulfur cluster binding
Rmag_0765	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Rmag_0766	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Rmag_0768	COG0494	nUDIX hydrolase
Rmag_0770	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Rmag_0777	COG0612	Peptidase, M16
Rmag_0778	COG0612	Peptidase, M16
Rmag_0781	COG0552	protein localization to endoplasmic reticulum
Rmag_0783	COG0181	hydroxymethylbilane synthase activity
Rmag_0784	COG0165	Argininosuccinate lyase
Rmag_0785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Rmag_0786	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Rmag_0788	COG4660	Part of a membrane complex involved in electron transport
Rmag_0790	COG2890	protein-(glutamine-N5) methyltransferase activity
Rmag_0793	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Rmag_0793	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Rmag_0794	COG1077	Cell shape determining protein MreB Mrl
Rmag_0795	COG1792	Involved in formation and maintenance of cell shape
Rmag_0797	COG0768	penicillin binding
Rmag_0799	COG5265	(ABC) transporter
Rmag_0800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Rmag_0800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Rmag_0801	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Rmag_0803	COG0587	DNA-directed DNA polymerase activity
Rmag_0805	COG3258	Cytochrome c
Rmag_0810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Rmag_0811	COG0085	RNA polymerase activity
Rmag_0812	COG0222	ribosome binding
Rmag_0813	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Rmag_0814	COG0081	regulation of translation
Rmag_0815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Rmag_0818	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Rmag_0819	COG0281	malic enzyme
Rmag_0821	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Rmag_0821	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Rmag_0822	COG0537	adenosine 5'-monophosphoramidase activity
Rmag_0825	COG0778	Nitroreductase
Rmag_0826	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Rmag_0828	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Rmag_0831	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Rmag_0833	COG1765	OsmC-like protein
Rmag_0834	COG2022	thiamine diphosphate biosynthetic process
Rmag_0835	COG0156	8-amino-7-oxononanoate synthase activity
Rmag_0836	COG0596	Alpha beta hydrolase
Rmag_0837	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Rmag_0840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Rmag_0841	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Rmag_0842	COG2835	tetraacyldisaccharide 4'-kinase activity
Rmag_0843	COG1663	tetraacyldisaccharide 4'-kinase activity
Rmag_0844	COG4591	ABC-type transport system involved in lipoprotein release permease component
Rmag_0845	COG1136	(ABC) transporter
Rmag_0846	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Rmag_0847	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Rmag_0848	COG5016	pyruvate
Rmag_0848	COG0511	ligase activity, forming carbon-carbon bonds
Rmag_0850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Rmag_0851	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Rmag_0856	COG0802	atpase or kinase
Rmag_0858	COG1797	cobyrinic acid a,c-diamide synthase activity
Rmag_0865	COG2920	part of a sulfur-relay system
Rmag_0867	COG2923	Belongs to the DsrF TusC family
Rmag_0868	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Rmag_0869	COG2221	Nitrite and sulphite reductase 4Fe-4S
Rmag_0870	COG2221	Nitrite and sulphite reductase 4Fe-4S
Rmag_0871	COG0493	'glutamate synthase
Rmag_0872	COG0335	large ribosomal subunit rRNA binding
Rmag_0874	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Rmag_0875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Rmag_0876	COG2853	Lipoprotein
Rmag_0877	COG0505	Belongs to the CarA family
Rmag_0880	COG0482	sulfurtransferase activity
Rmag_0882	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Rmag_0883	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Rmag_0884	COG0166	Belongs to the GPI family
Rmag_0887	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Rmag_0889	COG1216	Glycosyl transferase, family 2
Rmag_0890	COG0438	transferase activity, transferring glycosyl groups
Rmag_0891	COG1216	Glycosyl transferase, family 2
Rmag_0892	COG3475	LICD family
Rmag_0902	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Rmag_0903	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Rmag_0909	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Rmag_0910	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Rmag_0911	COG0542	response to heat
Rmag_0912	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Rmag_0913	COG0795	lipopolysaccharide-transporting ATPase activity
Rmag_0914	COG0519	Catalyzes the synthesis of GMP from XMP
Rmag_0914	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Rmag_0915	COG0590	tRNA wobble adenosine to inosine editing
Rmag_0917	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Rmag_0918	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Rmag_0919	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Rmag_0920	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Rmag_0921	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Rmag_0922	COG0557	exoribonuclease II activity
Rmag_0923	COG0509	glycine decarboxylation via glycine cleavage system
Rmag_0924	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Rmag_0925	COG2917	probably involved in intracellular septation
Rmag_0929	COG3161	chorismate lyase activity
Rmag_0930	COG2226	methyltransferase
Rmag_0931	COG0512	Glutamine amidotransferase of anthranilate synthase
Rmag_0932	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Rmag_0934	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Rmag_0935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Rmag_0936	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Rmag_0939	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Rmag_0942	COG0513	Belongs to the DEAD box helicase family
Rmag_0944	COG1278	Cold shock
Rmag_0946	COG2925	Exonuclease
Rmag_0947	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Rmag_0949	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Rmag_0950	COG0131	Imidazoleglycerol-phosphate dehydratase
Rmag_0951	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Rmag_0953	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Rmag_0954	COG0351	phosphomethylpyrimidine kinase
Rmag_0956	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Rmag_0957	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Rmag_0958	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Rmag_0960	COG0842	Transport permease protein
Rmag_0961	COG1131	(ABC) transporter
Rmag_0962	COG0508	dehydrogenase complex catalyzes the overall conversion of
Rmag_0963	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Rmag_0964	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Rmag_0969	COG0138	bifunctional purine biosynthesis protein purh
Rmag_0971	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Rmag_0972	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Rmag_0973	COG0312	modulator of DNA gyrase
Rmag_0975	COG4535	Mg2 and Co2 transporter CorC
Rmag_0976	COG2914	Belongs to the UPF0125 (RnfH) family
Rmag_0977	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Rmag_0978	COG0346	lactoylglutathione lyase activity
Rmag_0980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Rmag_0981	COG1137	ATPase activity
Rmag_0983	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Rmag_0984	COG0101	tRNA pseudouridine synthase activity
Rmag_0985	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Rmag_0986	COG0583	DNA-binding transcription factor activity
Rmag_0987	COG0471	metal ion transport
Rmag_0987	COG3273	potassium ion transport
Rmag_0989	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Rmag_0990	COG0228	four-way junction DNA binding
Rmag_0991	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Rmag_0992	COG1049	propionate catabolic process, 2-methylcitrate cycle
Rmag_0993	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Rmag_0994	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Rmag_0995	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Rmag_0996	COG0708	Exodeoxyribonuclease III
Rmag_0997	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Rmag_0998	COG3030	protein affecting phage T7 exclusion by the F plasmid
Rmag_0999	COG0285	dihydrofolate synthase activity
Rmag_1003	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Rmag_1005	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Rmag_1006	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Rmag_1007	COG1862	Preprotein translocase
Rmag_1008	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Rmag_1012	COG2197	response regulator
Rmag_1013	COG3850	Histidine kinase
Rmag_1014	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Rmag_1015	COG2918	glutathione biosynthetic process
Rmag_1016	COG0494	nUDIX hydrolase
Rmag_1018	COG0070	glutamate synthase
Rmag_1018	COG0069	glutamate synthase activity
Rmag_1018	COG0067	glutamate synthase
Rmag_1021	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Rmag_1023	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Rmag_1024	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Rmag_1025	COG0159	tryptophan synthase activity
Rmag_1026	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Rmag_1027	COG0254	rRNA binding
Rmag_1028	COG2217	Heavy metal translocating P-type atpase
Rmag_1030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Rmag_1031	COG0133	tryptophan synthase activity
Rmag_1032	COG0135	phosphoribosylanthranilate isomerase activity
Rmag_1035	COG2922	Belongs to the Smg family
Rmag_1037	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Rmag_1038	COG0594	ribonuclease P activity
Rmag_1039	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Rmag_1040	COG0706	membrane insertase activity
Rmag_1042	COG3023	N-Acetylmuramoyl-L-alanine amidase
Rmag_1043	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Rmag_1044	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Rmag_1045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Rmag_1046	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Rmag_1047	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Rmag_1048	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Rmag_1049	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Rmag_1051	COG0356	it plays a direct role in the translocation of protons across the membrane
Rmag_1053	COG0446	pyridine nucleotide-disulphide oxidoreductase
Rmag_1054	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Rmag_1055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Rmag_1057	COG4232	protein-disulfide reductase activity
Rmag_1058	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Rmag_1059	COG0511	ligase activity, forming carbon-carbon bonds
Rmag_1060	COG0439	Biotin carboxylase
Rmag_1061	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Rmag_1062	COG0316	Belongs to the HesB IscA family
Rmag_1066	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Rmag_1067	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Rmag_1068	COG0193	aminoacyl-tRNA hydrolase activity
Rmag_1069	COG0012	GTP binding
Rmag_1070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Rmag_1072	COG0052	Belongs to the universal ribosomal protein uS2 family
Rmag_1073	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Rmag_1076	COG0149	triose-phosphate isomerase activity