locus-tag	class	description
IPH19_00015	COG0494	nUDIX hydrolase
IPH19_00035	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IPH19_00055	COG2001	Belongs to the MraZ family
IPH19_00060	COG0275	rRNA processing
IPH19_00075	COG0542	response to heat
IPH19_00085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPH19_00095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPH19_00100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPH19_00105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IPH19_00110	COG0305	Participates in initiation and elongation during chromosome replication
IPH19_00135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPH19_00150	COG0504	CTP synthase activity
IPH19_00155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IPH19_00170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPH19_00175	COG0772	Belongs to the SEDS family
IPH19_00180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPH19_00190	COG0142	geranyltranstransferase activity
IPH19_00195	COG1562	ergosterol biosynthetic process
IPH19_00225	COG0438	transferase activity, transferring glycosyl groups
IPH19_00230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPH19_00240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPH19_00270	COG2852	Protein conserved in bacteria
IPH19_00275	COG0556	nucleotide-excision repair
IPH19_00295	COG0358	DNA primase activity
IPH19_00305	COG2081	HI0933 family
IPH19_00315	COG0488	(ABC) transporter
IPH19_00340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPH19_00355	COG0527	aspartate kinase activity
IPH19_00400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IPH19_00405	COG0768	penicillin binding
IPH19_00410	COG0768	penicillin binding
IPH19_00415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPH19_00435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPH19_00440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPH19_00445	COG1381	Involved in DNA repair and RecF pathway recombination
IPH19_00455	COG0017	Asparaginyl-tRNA synthetase
IPH19_00475	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPH19_00480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IPH19_00495	COG0438	transferase activity, transferring glycosyl groups
IPH19_00525	COG1192	Involved in chromosome partitioning
IPH19_00545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPH19_00545	COG1754	DNA topoisomerase type I activity
IPH19_00555	COG0758	DNA mediated transformation
IPH19_00565	COG1160	GTP binding
IPH19_00570	COG1160	GTP binding
IPH19_00575	COG1316	TRANSCRIPTIONal
IPH19_00660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IPH19_00675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPH19_00680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPH19_00685	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPH19_00715	COG0588	phosphoglycerate mutase activity
IPH19_00720	COG0542	response to heat
IPH19_00725	COG0542	response to heat
IPH19_00730	COG0501	Belongs to the peptidase M48B family
IPH19_00735	COG1704	LemA family
IPH19_00745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPH19_00750	COG0750	zinc metalloprotease
IPH19_00755	COG0750	zinc metalloprotease
IPH19_00760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPH19_00770	COG0072	phenylalanine-tRNA ligase activity
IPH19_00770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPH19_00800	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPH19_00805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IPH19_00835	COG1217	gtp-binding protein TYPA
IPH19_00870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPH19_00875	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPH19_00895	COG2949	membrane
IPH19_00915	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPH19_00920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPH19_00925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPH19_00930	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IPH19_00935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPH19_00940	COG0768	penicillin binding
IPH19_00955	COG1077	Cell shape determining protein MreB Mrl
IPH19_00970	COG0210	DNA helicase
IPH19_00980	COG0343	queuine tRNA-ribosyltransferase activity
IPH19_01015	COG0018	arginyl-trna synthetase
IPH19_01020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPH19_01030	COG0525	valine-tRNA ligase activity
IPH19_01045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPH19_01070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPH19_01090	COG0793	Belongs to the peptidase S41A family
IPH19_01090	COG3409	Peptidoglycan-binding domain 1 protein
IPH19_01095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPH19_01115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
IPH19_01130	COG0732	type I restriction modification DNA specificity domain
IPH19_01145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPH19_01150	COG1741	Belongs to the pirin family
IPH19_01195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IPH19_01200	COG0242	peptide deformylase activity
IPH19_01205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPH19_01220	COG1216	Glycosyl transferase, family 2
IPH19_01225	COG0438	transferase activity, transferring glycosyl groups
IPH19_01250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPH19_01255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPH19_01260	COG0203	ribosomal protein L17
IPH19_01265	COG0202	RNA polymerase activity
IPH19_01270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IPH19_01280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPH19_01285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPH19_01290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPH19_01300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPH19_01310	COG0482	sulfurtransferase activity
IPH19_01315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPH19_01330	COG1968	undecaprenyl-diphosphatase activity
IPH19_01345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPH19_01350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPH19_01350	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPH19_01355	COG0706	membrane insertase activity
IPH19_01360	COG0195	Participates in both transcription termination and antitermination
IPH19_01425	COG3118	belongs to the thioredoxin family
IPH19_01430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPH19_01440	COG1418	mRNA catabolic process
IPH19_01460	COG0442	prolyl-tRNA aminoacylation
IPH19_01480	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPH19_01485	COG0698	ribose 5-phosphate isomerase
IPH19_01490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPH19_01515	COG3959	Transketolase, thiamine diphosphate binding domain
IPH19_01525	COG3958	Transketolase
IPH19_01535	COG0492	ferredoxin-NADP+ reductase activity
IPH19_01575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPH19_01580	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPH19_01585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPH19_01600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPH19_01640	COG1610	YqeY-like protein
IPH19_01650	COG0124	histidyl-tRNA synthetase
IPH19_01675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPH19_01680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPH19_01725	COG0148	phosphopyruvate hydratase activity
IPH19_01730	COG2968	Membrane
IPH19_01745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPH19_01750	COG0052	Belongs to the universal ribosomal protein uS2 family
IPH19_01780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPH19_01785	COG0254	rRNA binding
IPH19_01805	COG1216	Glycosyl transferase, family 2
IPH19_01815	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IPH19_01880	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPH19_01895	COG4818	TM2 domain
IPH19_01910	COG3706	GGDEF domain
IPH19_01930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPH19_01950	COG0215	cysteine-tRNA ligase activity
IPH19_01955	COG0602	queuosine metabolic process
IPH19_01970	COG1595	DNA-templated transcription, initiation
IPH19_01990	COG0484	heat shock protein binding
IPH19_02015	COG1420	regulation of RNA biosynthetic process
IPH19_02080	COG1136	(ABC) transporter
IPH19_02080	COG0577	efflux transmembrane transporter activity
IPH19_02090	COG0577	efflux transmembrane transporter activity
IPH19_02090	COG1136	(ABC) transporter
IPH19_02095	COG1136	(ABC) transporter
IPH19_02095	COG4591	ABC-type transport system involved in lipoprotein release permease component
IPH19_02130	COG0438	transferase activity, transferring glycosyl groups
IPH19_02170	COG1077	Cell shape determining protein MreB Mrl
IPH19_02230	COG1950	PFAM Membrane protein of
IPH19_02240	COG1570	exodeoxyribonuclease VII activity
IPH19_02275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPH19_02285	COG0210	DNA helicase
IPH19_02305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IPH19_02310	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IPH19_02355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPH19_02385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPH19_02390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPH19_02435	COG0612	Peptidase, M16
IPH19_02440	COG0423	glycine-tRNA ligase activity
IPH19_02445	COG0233	cytoplasmic translational termination
IPH19_02490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPH19_02500	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPH19_02510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPH19_02515	COG0628	permease
IPH19_02535	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPH19_02565	COG0438	transferase activity, transferring glycosyl groups
IPH19_02580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IPH19_02585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IPH19_02615	COG0105	UTP biosynthetic process
IPH19_02630	COG0571	ribonuclease III activity
IPH19_02645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPH19_02650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPH19_02685	COG2852	Protein conserved in bacteria
IPH19_02700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPH19_02735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPH19_02760	COG0488	(ABC) transporter
IPH19_02780	COG0564	pseudouridine synthase activity
IPH19_02785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPH19_02795	COG0335	large ribosomal subunit rRNA binding
IPH19_02830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPH19_02850	COG4166	transmembrane transport
IPH19_02870	COG0463	Glycosyl transferase, family 2
IPH19_02875	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPH19_03055	COG2259	Doxx family
IPH19_03065	COG0632	four-way junction helicase activity
IPH19_03070	COG0632	four-way junction helicase activity
IPH19_03075	COG1435	thymidine kinase activity
IPH19_03095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPH19_03105	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IPH19_03110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPH19_03140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPH19_03145	COG0085	RNA polymerase activity
IPH19_03200	COG1674	ftsk spoiiie
IPH19_03205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPH19_03225	COG0012	GTP binding
IPH19_03245	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPH19_03260	COG1872	DUF167
IPH19_03265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IPH19_03275	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPH19_03280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPH19_03285	COG0592	DNA-directed DNA polymerase activity
IPH19_03290	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IPH19_03310	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPH19_03310	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPH19_03430	COG0739	heme binding
IPH19_03435	COG0606	chelatase, subunit chli
IPH19_03440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPH19_03455	COG1185	polyribonucleotide nucleotidyltransferase activity
IPH19_03465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPH19_03475	COG0495	leucyl-tRNA aminoacylation
IPH19_03480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IPH19_03590	COG0588	phosphoglycerate mutase activity
IPH19_03600	COG2217	Heavy metal translocating P-type atpase
IPH19_03610	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IPH19_03625	COG1104	cysteine desulfurase activity
IPH19_03660	COG0360	Binds together with S18 to 16S ribosomal RNA
IPH19_03665	COG0629	single-stranded DNA binding
IPH19_03670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPH19_03680	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
IPH19_03690	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPH19_03755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IPH19_03860	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPH19_03865	COG1196	nuclear chromosome segregation
IPH19_03865	COG1196	nuclear chromosome segregation
IPH19_03870	COG0228	four-way junction DNA binding
IPH19_03880	COG0336	Belongs to the RNA methyltransferase TrmD family
IPH19_03890	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IPH19_03905	COG0678	peroxiredoxin activity
IPH19_03915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPH19_03930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IPH19_03945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPH19_03950	COG0539	negative regulation of cytoplasmic translation
IPH19_04035	COG0167	dihydroorotate dehydrogenase activity
IPH19_04060	COG0514	ATP-dependent DNA helicase (RecQ)
IPH19_04070	COG1278	Cold shock
IPH19_04105	COG2255	four-way junction helicase activity
IPH19_04110	COG0586	Pfam SNARE associated Golgi protein
IPH19_04165	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IPH19_04165	COG1796	DNA polymerase
IPH19_04185	COG0542	response to heat
IPH19_04195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IPH19_04200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPH19_04200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPH19_04210	COG0084	hydrolase, TatD family'
IPH19_04230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IPH19_04240	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPH19_04245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPH19_04245	COG1017	nitric oxide dioxygenase activity
IPH19_04305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPH19_04315	COG1379	DNA repair
IPH19_04325	COG0724	RNA recognition motif
IPH19_04330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPH19_04345	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPH19_04350	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IPH19_04380	COG0756	dUTP diphosphatase activity
IPH19_04390	COG0081	regulation of translation
IPH19_04400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPH19_04405	COG0250	Participates in transcription elongation, termination and antitermination
IPH19_04410	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IPH19_04425	COG0776	regulation of translation
IPH19_04435	COG1611	Belongs to the LOG family
IPH19_04440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPH19_04445	COG1994	Peptidase M50
IPH19_04450	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPH19_04455	COG0049	tRNA binding
IPH19_04460	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPH19_04465	COG1132	(ABC) transporter
IPH19_04485	COG0051	transcription antitermination factor activity, RNA binding
IPH19_04490	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPH19_04495	COG0088	Forms part of the polypeptide exit tunnel
IPH19_04500	COG0089	rRNA binding
IPH19_04505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPH19_04510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPH19_04515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPH19_04520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPH19_04525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPH19_04540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPH19_04545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPH19_04550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPH19_04555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IPH19_04560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPH19_04565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPH19_04570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPH19_04575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPH19_04580	COG0200	Binds to the 23S rRNA
IPH19_04590	COG0563	adenylate kinase activity
IPH19_04595	COG0024	Methionine aminopeptidase
IPH19_04605	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPH19_04610	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPH19_04655	COG1595	DNA-templated transcription, initiation
IPH19_04700	COG2249	NAD(P)H dehydrogenase (quinone) activity
IPH19_04705	COG4628	conserved protein (DUF2132)
IPH19_04750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IPH19_04755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPH19_04765	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPH19_04770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPH19_04780	COG0653	protein targeting
IPH19_04785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPH19_04795	COG2267	carboxylic ester hydrolase activity
IPH19_04795	COG2226	methyltransferase
IPH19_04805	COG2226	methyltransferase
IPH19_04815	COG0792	nuclease activity
IPH19_04855	COG0367	asparagine synthase
IPH19_04880	COG0438	transferase activity, transferring glycosyl groups
IPH19_04900	COG2226	methyltransferase
IPH19_04910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPH19_04920	COG0367	asparagine synthase
IPH19_04940	COG0673	inositol 2-dehydrogenase activity
IPH19_04960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPH19_04970	COG2226	methyltransferase
IPH19_04980	COG0463	Glycosyl transferase, family 2
IPH19_04985	COG2226	methyltransferase
IPH19_04995	COG0438	transferase activity, transferring glycosyl groups
IPH19_05005	COG0367	asparagine synthase
IPH19_05010	COG0367	asparagine synthase
IPH19_05020	COG2226	methyltransferase
IPH19_05025	COG0367	asparagine synthase
IPH19_05030	COG0367	asparagine synthase
IPH19_05040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPH19_05045	COG1404	Belongs to the peptidase S8 family
IPH19_05050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPH19_05055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPH19_05070	COG0297	glycogen (starch) synthase activity
IPH19_05085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPH19_05090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPH19_05120	COG0772	Belongs to the SEDS family
IPH19_05130	COG0187	DNA topoisomerase II activity
IPH19_05145	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPH19_05150	COG1470	cell adhesion involved in biofilm formation
IPH19_05155	COG2890	protein-(glutamine-N5) methyltransferase activity
IPH19_05200	COG0281	malic enzyme
IPH19_05205	COG2884	Cell division ATP-binding protein ftsE
IPH19_05245	COG1131	(ABC) transporter
IPH19_05250	COG0842	Transport permease protein
IPH19_05260	COG0513	Belongs to the DEAD box helicase family
IPH19_05275	COG1525	nuclease
IPH19_05290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPH19_05315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPH19_05345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IPH19_05350	COG0463	Glycosyl transferase, family 2
IPH19_05365	COG0728	peptidoglycan biosynthetic process
IPH19_05375	COG0481	GTPase activity
IPH19_05390	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IPH19_05390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IPH19_05410	COG0328	RNA-DNA hybrid ribonuclease activity
IPH19_05430	COG2201	protein-glutamate methylesterase activity
IPH19_05440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IPH19_05445	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPH19_05455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPH19_05460	COG0154	amidase activity
IPH19_05475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IPH19_05490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IPH19_05490	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IPH19_05535	COG2222	sugar isomerase
IPH19_05555	COG1733	regulation of RNA biosynthetic process
IPH19_05570	COG0789	Transcriptional regulator
IPH19_05575	COG0789	Transcriptional regulator
IPH19_05600	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)