locus-tag	class	description
A6E34_00055	ENOG4105D1S	lipid A biosynthesis
A6E34_00065	ENOG4105C8B	TIGR00159 family
A6E34_00070	ENOG4105C4M	(Ubiquinol oxidase) subunit I
A6E34_00075	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
A6E34_00080	ENOG4108IAB	Phoh family
A6E34_00110	ENOG4105C3F	Signal peptidase i
A6E34_00120	ENOG4105NRA	50s ribosomal protein l31 type b
A6E34_00135	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6E34_00175	ENOG4105C7H	Helicase, RecD TraA family
A6E34_00185	ENOG4105HS1	biotin--protein ligase
A6E34_00225	ENOG41083M4	protein CPn_0389 CP_0366 CPj0389 CpB0400
A6E34_00240	ENOG4108XV2	single-stranded DNA-binding protein
A6E34_00245	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
A6E34_00280	ENOG4105CSA	Coproporphyrinogen iii oxidase
A6E34_00295	ENOG4105C7S	Dehydrogenase
A6E34_00315	ENOG4105KXW	Ferredoxin
A6E34_00325	ENOG4105D7B	Flagellar biosynthesis protein flha
A6E34_00330	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A6E34_00340	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
A6E34_00350	ENOG4105E7T	carrier protein
A6E34_00360	ENOG4107SIG	periplasmic solute binding protein
A6E34_00365	ENOG4105DIK	(ABC) transporter
A6E34_00370	ENOG4107RPQ	ABC transporter
A6E34_00375	ENOG4107RBD	ABC, transporter
A6E34_00385	ENOG4105DZP	Membrane-associated zinc metalloprotease
A6E34_00400	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
A6E34_00410	ENOG4105CJ2	(LipO)protein
A6E34_00450	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
A6E34_00460	ENOG4108IUJ	4-alpha-glucanotransferase
A6E34_00485	ENOG4105C3G	gtp-binding protein
A6E34_00490	ENOG4105DTN	riboflavin biosynthesis protein ribF
A6E34_00495	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
A6E34_00510	ENOG4105CHV	Transcription elongation factor NusA
A6E34_00515	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
A6E34_00520	ENOG4105C3M	thioredoxin reductase
A6E34_00545	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
A6E34_00555	ENOG4105EMS	pseudouridine synthase
A6E34_00565	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
A6E34_00575	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
A6E34_00580	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
A6E34_00585	ENOG4105DPN	Oligoendopeptidase f
A6E34_00590	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
A6E34_00630	ENOG4105DJV	ribulose-phosphate 3-epimerase
A6E34_00635	ENOG4108S1P	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
A6E34_00640	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
A6E34_00645	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
A6E34_00655	ENOG4108UJD	30S ribosomal protein S9
A6E34_00670	ENOG4105E5Q	amino acid AbC transporter
A6E34_00675	ENOG4105CDA	abc transporter atp-binding protein
A6E34_00720	ENOG4108J59	Extracellular solute-binding protein, family 5
A6E34_00730	ENOG4106RHG	Yeca family
A6E34_00760	ENOG4105E6M	Sulphatase-modifying factor protein
A6E34_00775	ENOG4107SCK	Monooxygenase
A6E34_00795	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
A6E34_00885	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
A6E34_00915	ENOG4108J59	Extracellular solute-binding protein, family 5
A6E34_00920	ENOG4105KVY	Required for disulfide bond formation in some proteins (By similarity)
A6E34_00965	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
A6E34_00975	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
A6E34_00980	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
A6E34_00985	ENOG4107QMP	dna polymerase iii subunits gamma and tau
A6E34_00995	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A6E34_01000	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
A6E34_01020	ENOG4105CJW	magnesium transporter
A6E34_01040	ENOG4108J59	Extracellular solute-binding protein, family 5
A6E34_01045	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
A6E34_01050	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A6E34_01060	ENOG4107H6U	ABC transporter
A6E34_01065	ENOG4105QMX	Protein of unknown function (DUF1186)
A6E34_01070	ENOG4107QPK	)-transporter
A6E34_01075	ENOG4107RJF	diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90)
A6E34_01085	ENOG4105CTQ	phosphohexokinase
A6E34_01100	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
A6E34_01105	ENOG4105C8T	Leucyl-tRNA synthetase
A6E34_01110	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
A6E34_01115	ENOG4108UJU	UPF0301 protein
A6E34_01125	ENOG4105E66	phosphoriboisomerase A
A6E34_01135	ENOG4105EIE	fructose-bisphosphate aldolase
A6E34_01140	ENOG4105E5D	amino acid
A6E34_01150	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
A6E34_01155	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
A6E34_01160	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
A6E34_01165	ENOG4108JYZ	YitT family
A6E34_01230	ENOG4105C8J	)-transporter
A6E34_01260	ENOG4105CHR	reductase
A6E34_01265	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
A6E34_01280	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6E34_01285	ENOG4105NGJ	Skp-like protein
A6E34_01305	ENOG4105CPP	Dehydrogenase, E1 component
A6E34_01315	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
A6E34_01325	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
A6E34_01330	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
A6E34_01335	ENOG4107QYK	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
A6E34_01345	ENOG4105I7S	Abortive infection protein
A6E34_01360	ENOG4108JU6	CBS domain protein
A6E34_01370	ENOG4107QI6	Cysteine desulfurase
A6E34_01375	ENOG4108ZF3	Phosphatase
A6E34_01385	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
A6E34_01390	ENOG4105E63	Pfam:DUF178
A6E34_01400	ENOG4105BZ1	(ABC) transporter
A6E34_01415	ENOG41082SS	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions (By similarity)
A6E34_01420	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
A6E34_01430	ENOG4105CJN	penicillin-binding protein
A6E34_01455	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
A6E34_01475	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
A6E34_01510	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
A6E34_01515	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
A6E34_01530	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
A6E34_01535	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
A6E34_01545	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
A6E34_01550	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
A6E34_01570	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
A6E34_01575	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
A6E34_01605	ENOG4107VJ3	V-type ATP synthase subunit I (EC 3.6.3.14)
A6E34_01625	ENOG4108XKX	Protein of unknown function (DUF2764)
A6E34_01645	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
A6E34_01680	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
A6E34_01705	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
A6E34_01715	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
A6E34_01770	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
A6E34_01775	ENOG4105CA9	Pyruvate kinase
A6E34_01780	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
A6E34_01785	ENOG4105C6E	dna polymerase iii
A6E34_01790	ENOG41085QW	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
A6E34_01795	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
A6E34_01820	ENOG4105CPP	Dehydrogenase, E1 component
A6E34_01835	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
A6E34_01840	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
A6E34_01860	ENOG4105C5H	ABC transporter
A6E34_01895	ENOG4108X1H	
A6E34_01900	ENOG4105C7Z	Conserved Protein
A6E34_01940	ENOG4105CFH	Aspartokinase
A6E34_01945	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
A6E34_01960	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
A6E34_01980	ENOG4107TBS	Shikimate dehydrogenase
A6E34_01985	ENOG410653D	Protein of unknown function (DUF2608)
A6E34_01995	ENOG4108PHJ	Part of the AaxABC system, catalyzes the decarboxylation of L-arginine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response
A6E34_02010	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
A6E34_02020	ENOG4105C89	phosphohexose isomerase
A6E34_02025	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
A6E34_02030	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
A6E34_02035	ENOG4106TNF	Periplasmic binding protein
A6E34_02040	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
A6E34_02060	ENOG41083IP	HIT family
A6E34_02065	ENOG4108KBP	metal-dependent protein hydrolase
A6E34_02105	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
A6E34_02120	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
A6E34_02135	ENOG4105C2X	Arabinose 5-phosphate isomerase
A6E34_02140	ENOG4105C7S	Dehydrogenase
A6E34_02150	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
A6E34_02165	ENOG4108R6K	riboflavin synthase, subunit alpha
A6E34_02175	ENOG4105SCY	DNAK suppressor
A6E34_02190	ENOG4105DJ0	Poly(A) Polymerase
A6E34_02200	ENOG4106BWJ	
A6E34_02220	ENOG4107XSR	periplasmic solute binding protein
A6E34_02225	ENOG4105DIK	(ABC) transporter
A6E34_02230	ENOG4105CC5	ABC transporter
A6E34_02235	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6E34_02240	ENOG4105K46	50S ribosomal protein l27
A6E34_02275	ENOG4105C37	(CBS) domain
A6E34_02280	ENOG41083UI	stage II sporulation protein
A6E34_02285	ENOG4108NVI	
A6E34_02290	ENOG4105DVY	radical SAM domain protein
A6E34_02305	ENOG4107IVX	UPF0158 protein CPn_0518 CP_0235 CPj0518 CpB0539
A6E34_02335	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
A6E34_02340	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
A6E34_02355	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
A6E34_02365	ENOG4105CN1	protease
A6E34_02375	ENOG4108U5Y	In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl- insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan
A6E34_02395	ENOG41090XM	Early upstream open reading frame
A6E34_02400	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
A6E34_02405	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
A6E34_02420	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
A6E34_02425	ENOG41082ER	phosphatidate Cytidylyltransferase
A6E34_02435	ENOG4105CEY	Amp-dependent synthetase and ligase
A6E34_02455	ENOG4105CDY	transcriptional regulatory protein
A6E34_02460	ENOG4105WCN	acetyltransferase
A6E34_02475	ENOG4107XAV	metallophosphoesterase
A6E34_02490	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
A6E34_02510	ENOG4105BZU	Histidine kinase
A6E34_02515	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
A6E34_02565	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
A6E34_02580	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
A6E34_02620	ENOG4107SF0	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
A6E34_02630	ENOG4106H78	methyltransferase
A6E34_02640	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
A6E34_02650	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
A6E34_02655	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
A6E34_02660	ENOG4105C2M	dna polymerase I
A6E34_02665	ENOG4105D07	Signal peptide peptidase, SppA
A6E34_02675	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
A6E34_02690	ENOG4105CDU	Replicative dna helicase
A6E34_02710	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
A6E34_02745	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
A6E34_02750	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
A6E34_02760	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
A6E34_02770	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
A6E34_02780	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
A6E34_02795	ENOG41084J6	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
A6E34_02815	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
A6E34_02830	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
A6E34_02880	ENOG4107RI4	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
A6E34_02885	ENOG4108S4H	thioesterase Superfamily protein
A6E34_02890	ENOG4105UMD	exodeoxyribonuclease X
A6E34_02895	ENOG4105K8N	protein family UPF0079, ATPase
A6E34_02900	ENOG4108C2G	Protein of unknown function (DUF2709)
A6E34_02910	ENOG4105K63	Thioredoxin
A6E34_02915	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
A6E34_02920	ENOG410801I	Peptidyl-prolyl cis-trans isomerase
A6E34_02935	ENOG4105CXY	transporter
A6E34_02940	ENOG4105C0B	DNA polymerase III (alpha subunit)
A6E34_02970	ENOG4105DZ1	carboxypeptidase
A6E34_02985	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
A6E34_02990	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
A6E34_03005	ENOG4107QN2	dihydrolipoyl dehydrogenase
A6E34_03045	ENOG4108TN6	type iii secretion
A6E34_03070	ENOG4106ABR	general secretion pathway protein G
A6E34_03075	ENOG4105D7Q	type ii secretion system
A6E34_03080	ENOG4107QHF	type ii secretion system protein e
A6E34_03085	ENOG4105E4G	Type IV pilus
A6E34_03140	ENOG4105C2U	cobyrinic Acid a,c-diamide synthase
A6E34_03145	ENOG4106MFV	virulence plasmid
A6E34_03155	ENOG4105C31	Tryptophanyl-tRNA synthetase
A6E34_03160	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
A6E34_03185	ENOG4105E33	succinate dehydrogenase
A6E34_03205	ENOG4105F8V	Hydrolase, tatD family
A6E34_03215	ENOG4105M8K	biopolymer transport protein
A6E34_03220	ENOG4105M8F	Biopolymer transport protein exbD tolR
A6E34_03235	ENOG4105KCK	Peptidoglycan-associated lipoprotein
A6E34_03240	ENOG4105FEA	Spore maturation protein
A6E34_03265	ENOG4105EHZ	conserved protein UCP016719
A6E34_03285	ENOG4105C4R	Atp-dependent dna helicase
A6E34_03290	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A6E34_03320	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
A6E34_03365	ENOG4107X8J	Protein MurJ homolog
A6E34_03380	ENOG4105C72	UPF0176 protein
A6E34_03385	ENOG4105CTB	Polyprenyl synthetase
A6E34_03390	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
A6E34_03410	ENOG4108P8V	Thymidylate synthase complementing protein ThyX
A6E34_03415	ENOG4105D52	delta-aminolevulinic acid dehydratase
A6E34_03430	ENOG4107U85	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
A6E34_03440	ENOG4105CGF	Aromatic amino acid aminotransferase
A6E34_03450	ENOG4107QKA	exodeoxyribonuclease V beta
A6E34_03460	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
A6E34_03470	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
A6E34_03500	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
A6E34_03515	ENOG4107QYX	exodeoxyribonuclease v alpha
A6E34_03525	ENOG4108IUZ	ABC transporter
A6E34_03555	ENOG4105C34	Pseudouridine synthase
A6E34_03560	ENOG4105VB6	UPF0109 protein
A6E34_03565	ENOG4105DF5	DNA topoisomerase IV, subunit A
A6E34_03570	ENOG4105DNX	Dna topoisomerase iv (Subunit b)
A6E34_03575	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
A6E34_03590	ENOG4106FH8	
A6E34_03630	ENOG4105D9P	serine threonine protein kinase
A6E34_03645	ENOG41066A3	ATP guanido phosphotransferase
A6E34_03670	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
A6E34_03695	ENOG4105CJN	penicillin-binding protein
A6E34_03710	ENOG4105C3K	feS assembly ATPase SufC
A6E34_03715	ENOG4105JRK	feS assembly protein SufD
A6E34_03720	ENOG4105C9B	Cysteine desulfurase
A6E34_03725	ENOG4105FA0	parb-like partition protein
A6E34_03730	ENOG4108JQ7	(ABC) transporter
A6E34_03735	ENOG4105C3U	ABC transporter
A6E34_03740	ENOG4107IX6	phosphate transport regulator
A6E34_03745	ENOG4107QXV	Phosphate transporter
A6E34_03770	ENOG4105CSM	endonuclease III
A6E34_03800	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
A6E34_03810	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
A6E34_03840	ENOG4105DFF	Rod shape-determining protein mreb
A6E34_03845	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
A6E34_03870	ENOG4108MYC	UTP-glucose-1-phosphate uridylyltransferase
A6E34_03910	ENOG4105FE9	pseudouridine synthase
A6E34_03920	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
A6E34_03925	ENOG4105CNI	cell division protein FtsW
A6E34_03945	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
A6E34_03950	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
A6E34_03965	ENOG41069E2	(LipO)protein
A6E34_03970	ENOG4105BZG	amino acid carrier protein
A6E34_03975	ENOG4108V1U	phospholipid-binding protein
A6E34_03985	ENOG4105Q2H	domain protein
A6E34_03990	ENOG4105CNU	cell division protein FtsK
A6E34_04020	ENOG4108JFA	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity)
A6E34_04025	ENOG41084RR	Preprotein translocase subunit YajC
A6E34_04030	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
A6E34_04035	ENOG4106AP9	histone H1-like protein
A6E34_04045	ENOG4105C1Q	protoporphyrinogen oxidase
A6E34_04050	ENOG4105D4P	Coproporphyrinogen iii oxidase
A6E34_04060	ENOG4108JA2	transcriptioN-repair coupling factor
A6E34_04090	ENOG4105CV1	Transketolase (EC 2.2.1.1)
A6E34_04100	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
A6E34_04115	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
A6E34_04125	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
A6E34_04145	ENOG4105CNI	cell division protein FtsW
A6E34_04155	ENOG4105DFU	Cell wall formation (By similarity)
A6E34_04160	ENOG4105VB6	UPF0109 protein
A6E34_04170	ENOG41083UI	stage II sporulation protein
A6E34_04180	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
A6E34_04200	ENOG41062IR	nudix hydrolase
A6E34_04230	ENOG4105CEY	Amp-dependent synthetase and ligase
A6E34_04235	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
A6E34_04240	ENOG4105C25	Primosomal protein n'
A6E34_04250	ENOG4105MH8	Thioredoxin disulfide isomerase
A6E34_04270	ENOG41067YR	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
A6E34_04310	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
A6E34_04320	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
A6E34_04340	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
A6E34_04345	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
A6E34_04355	ENOG4108227	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
A6E34_04405	ENOG4105C03	ribonuclease
A6E34_04455	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
A6E34_04460	ENOG4105E0U	tyrosine-specific transport protein
A6E34_04465	ENOG4105E0U	tyrosine-specific transport protein
A6E34_04470	ENOG4105HFZ	Membrane
A6E34_04475	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
A6E34_04485	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
A6E34_04490	ENOG4105C0H	protease
A6E34_04500	ENOG4105CGY	Dna recombination protein
A6E34_04510	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A6E34_04515	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
A6E34_04520	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
A6E34_04545	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
A6E34_04550	ENOG4107MK0	50s ribosomal protein l35
A6E34_04595	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
A6E34_04600	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
A6E34_04605	ENOG4108Z6B	deaminase
A6E34_04645	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
A6E34_04650	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
A6E34_04660	ENOG4105Y36	Binding-protein-dependent transport systems, inner membrane component
A6E34_04665	ENOG4105C9Q	fumarate hydratase class II
A6E34_04670	ENOG4105CHH	sulfate transporter
A6E34_04690	ENOG4108NIU	serine-type peptidase activity
A6E34_04730	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)