locus-tag class description AB180_00010 ENOG4105YB8 TM2 domain containing protein AB180_00015 ENOG410814C multidrug resistance protein AB180_00070 ENOG4105M5B (LipO)protein AB180_00075 ENOG4105M5B (LipO)protein AB180_00090 ENOG4107YVC modification (methylase) AB180_00240 ENOG4105CMM transposase AB180_00285 ENOG4105E4C Lytic transglycosylase catalytic AB180_00335 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AB180_00425 ENOG4105EQR Transposase IS116 IS110 IS902 AB180_00475 ENOG4105MVE transcriptional regulator AB180_00660 ENOG4108XS9 dna repair protein AB180_00685 ENOG4105KF5 hemolysin expression-modulating protein AB180_00720 ENOG4107XMK single-stranded DNA-binding protein AB180_00815 ENOG4108UUM single-stranded DNA-binding protein AB180_00830 ENOG4105MPK DNA polymerase III subunit theta AB180_00850 ENOG41073YN Protein of unknown function (DUF1380) AB180_00865 ENOG4108RAV Conserved protein AB180_00900 ENOG4105FDK ABC transporter AB180_00910 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB AB180_00915 ENOG4105EZN Cobyrinic acid ac-diamide synthase AB180_00935 ENOG4108YXQ IS66 Orf2 family protein AB180_00945 ENOG4105F9F transposase AB180_00955 ENOG4105F2I Transposase AB180_00970 ENOG4106JVB Replication Protein AB180_00985 ENOG4105EQR Transposase IS116 IS110 IS902 AB180_00990 ENOG4105CHH sulfate transporter AB180_01020 ENOG4105EQR Transposase IS116 IS110 IS902 AB180_01030 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AB180_01045 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AB180_01050 ENOG4105EQR Transposase IS116 IS110 IS902 AB180_01065 ENOG4105F2I Transposase AB180_01070 ENOG4108MVM Transposase AB180_01075 ENOG4108ZQS transposase AB180_01080 ENOG4108UEC Ferritin-like protein AB180_01090 ENOG4105D13 transposase AB180_01115 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A AB180_01130 ENOG4105CNN ABC, transporter AB180_01135 ENOG4105C2J ABC transporter AB180_01140 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AB180_01145 ENOG4105ETE Transcriptional regulator (LacI family AB180_01310 ENOG4105D13 transposase AB180_01625 ENOG4105I1F Resistance protein AB180_01710 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AB180_01800 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AB180_01815 ENOG4105EQR Transposase IS116 IS110 IS902 AB180_01895 ENOG4108UEC Ferritin-like protein AB180_01900 ENOG4105F2I Transposase AB180_01915 ENOG4105EQR Transposase IS116 IS110 IS902 AB180_01930 ENOG4105KT5 UmuD protein AB180_01935 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AB180_01950 ENOG4105HVQ Regulatory factor of maltose metabolism AB180_02090 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AB180_02095 ENOG4105DFE Dna adenine methylase AB180_02105 ENOG4105DH7 May be involved in recombination (By similarity) AB180_02155 ENOG4105F2I Transposase AB180_02240 ENOG4105C3F Signal peptidase i AB180_02290 ENOG4105C4R Atp-dependent dna helicase AB180_02565 ENOG4107712 AB180_02630 ENOG4105DVT helicase AB180_02805 ENOG4105C2U cobyrinic Acid a,c-diamide synthase AB180_02860 ENOG4105CDU Replicative dna helicase AB180_02965 ENOG4106JVB Replication Protein AB180_02975 ENOG4105C5H ABC transporter AB180_02980 ENOG4105F1S paraquat-inducible protein a AB180_02985 ENOG4105DY2 Paraquat-inducible protein b AB180_02990 ENOG4108Q2G (LipO)protein AB180_03000 ENOG4105DAN ATP-dependent protease AB180_03005 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) AB180_03010 ENOG4105UYK outer membrane protein a AB180_03015 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) AB180_03020 ENOG4108RZ1 DNA transformation protein AB180_03025 ENOG4105EM2 membrane AB180_03030 ENOG410901E Membrane AB180_03035 ENOG41088T4 Helicase IV AB180_03045 ENOG4108Q67 UPF0319 protein AB180_03050 ENOG4105K4P CoA-binding domain protein AB180_03055 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) AB180_03060 ENOG4105DR4 Methyltransferase AB180_03065 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AB180_03075 ENOG4108MN8 Membrane AB180_03080 ENOG4107QSI ABC, transporter AB180_03095 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AB180_03100 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AB180_03110 ENOG4105E0A ABC, transporter AB180_03115 ENOG4105EHG Permease protein AB180_03130 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type AB180_03155 ENOG4105DVC DnaJ domain protein AB180_03165 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase AB180_03180 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) AB180_03185 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AB180_03190 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AB180_03195 ENOG4107SJW iron permease, FTR1 AB180_03210 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AB180_03220 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AB180_03240 ENOG4108ZHR arsR family transcriptional regulator AB180_03245 ENOG4105D6F Phosphatase AB180_03250 ENOG4105XH3 AB180_03255 ENOG4105CS1 NAD(P)H quinone oxidoreductase AB180_03260 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 AB180_03270 ENOG4108R86 Transcriptional regulator AB180_03275 ENOG4105VTN Protein of unknown function (DUF1311) AB180_03280 ENOG4105C26 Dehydrogenase AB180_03285 ENOG4105CK7 Sodium proline symporter AB180_03290 ENOG4105EKT )-iron permease AB180_03295 ENOG410650H (LipO)protein AB180_03300 ENOG4105DBE peroxidase AB180_03305 ENOG4105D5M phosphate starvation-inducible protein AB180_03310 ENOG4108MJ5 VirK protein AB180_03320 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase AB180_03325 ENOG4107SSZ Phosphatase AB180_03330 ENOG4107XHZ cytoplasmic chaperone TorD family protein AB180_03335 ENOG4108UQ5 membrane protein YcdZ AB180_03340 ENOG4105P8Q Curli production assembly transport component CsgG AB180_03345 ENOG4108WYR Curli production assembly transport component, CsgF AB180_03350 ENOG4108XDW curli assembly protein CsgE AB180_03355 ENOG41086KC Transcriptional regulator AB180_03360 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers AB180_03380 ENOG4108UVJ appr-1-p processing domain protein AB180_03385 ENOG4107RZC phospholipase d AB180_03400 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) AB180_03405 ENOG4108W47 Acidic protein msyB AB180_03410 ENOG4106KTS Inner membrane protein yeaI AB180_03415 ENOG4105C6X Major Facilitator AB180_03420 ENOG4105D1S lipid A biosynthesis AB180_03430 ENOG4108YYC ycei family AB180_03435 ENOG4105DS1 cytochrome b561 AB180_03440 ENOG4105F76 Sarcosine oxidase AB180_03445 ENOG4105PVA Biofilm formation regulatory protein BssS AB180_03450 ENOG4105MEA DNA damage-inducible protein i AB180_03455 ENOG4105EKE dihydroorotase AB180_03460 ENOG4105F3T (LipO)protein AB180_03465 ENOG4105EV4 Multidrug resistance protein mdtH AB180_03470 ENOG4105D9U N-acetyltransferase AB180_03475 ENOG4108YXG UPF0502 protein AB180_03480 ENOG4105EP9 oxidoreductase AB180_03485 ENOG4105CJR Integral membrane protein (MviN AB180_03490 ENOG4105QVD Flagella synthesis protein FlgN AB180_03495 ENOG4105M9M anti-sigma28 factor FlgM AB180_03500 ENOG4105CKS Flagella basal body P-ring formation protein flgA AB180_03505 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AB180_03510 ENOG4108ZC9 flagellar basal-body rod protein flgc AB180_03515 ENOG4105W00 Flagellar hook capping protein AB180_03520 ENOG4105BZE flagellar hook protein, FlgE AB180_03525 ENOG4108KPB Flagellar basal-body rod protein FlgF AB180_03530 ENOG4105CGA flagellar basal-body rod protein FlgG AB180_03540 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) AB180_03545 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AB180_03550 ENOG4105E1Q flagellar hook-associated protein AB180_03555 ENOG4105DTJ flagellar hook-associated protein AB180_03560 ENOG4105EQ0 Major Facilitator superfamily AB180_03565 ENOG4105EJC lysr family transcriptional regulator AB180_03570 ENOG4107QQB Ribonuclease E AB180_03575 ENOG4105EI2 Pseudouridine synthase AB180_03585 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AB180_03595 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) AB180_03600 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AB180_03605 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AB180_03610 ENOG4105CHR reductase AB180_03615 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AB180_03620 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AB180_03625 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AB180_03630 ENOG4105HHA aminodeoxychorismate lyase AB180_03635 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AB180_03640 ENOG4107QRG dna polymerase iii AB180_03645 ENOG4105F8V Hydrolase, tatD family AB180_03650 ENOG4105CI1 PTS System AB180_03660 ENOG4105FYV Amp nucleosidase AB180_03665 ENOG4105CSH Transporter AB180_03685 ENOG4105E0A ABC, transporter AB180_03690 ENOG4108IHU transport system permease protein AB180_03695 ENOG4105DQ5 transport system permease protein AB180_03700 ENOG4108HUF Transporter AB180_03705 ENOG4105GAV receptor AB180_03710 ENOG4108S3W Anti-feci sigma factor, fecr AB180_03715 ENOG4108SF5 RNA Polymerase AB180_03735 ENOG4105CR8 Transcriptional regulator AB180_03740 ENOG4108IJ0 Aspartate ammonia-lyase AB180_03745 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AB180_03765 ENOG4107R11 Transcriptional regulator AB180_03775 ENOG4105UQX Mate efflux family protein AB180_03785 ENOG4106UW1 Major Facilitator superfamily AB180_03790 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 AB180_03800 ENOG4105C45 hydrogenase expression formation protein (HypE) AB180_03815 ENOG4105K59 histidine triad (HIT) protein AB180_03820 ENOG41090DQ Lipoprotein AB180_03825 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) AB180_03845 ENOG4105CEP NADH dehydrogenase AB180_03850 ENOG4107MBR 17 kDa surface antigen AB180_03860 ENOG4108IND Tetr family transcriptional regulator AB180_03865 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction AB180_03870 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AB180_03875 ENOG4108JA2 transcriptioN-repair coupling factor AB180_03880 ENOG4105IQC Inner membrane protein YcfT AB180_03885 ENOG4105D60 lipoprotein releasing system transmembrane protein AB180_03895 ENOG4105D60 lipoprotein releasing system transmembrane protein AB180_03900 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AB180_03905 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AB180_03910 ENOG4107RUE extracellular solute-binding protein family 1 AB180_03915 ENOG4105D38 putrescine abc transporter AB180_03920 ENOG4105F38 ABC transporter, permease AB180_03930 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AB180_03935 ENOG4105EZE Cupin 4 family protein AB180_03945 ENOG4105XJC Two component transcriptional regulator (Winged helix family AB180_03950 ENOG4107R08 Integrase AB180_03955 ENOG4107160 Rac prophage AB180_03970 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AB180_04045 ENOG4105QBX endodeoxyribonuclease RusA AB180_04085 ENOG4108YV9 Protein of unknown function (DUF2514) AB180_04105 ENOG4106IAW AB180_04110 ENOG4108VKM cytochrome b561 AB180_04125 ENOG4105CAR Terminase, large subunit AB180_04140 ENOG4105D07 Signal peptide peptidase, SppA AB180_04230 ENOG4108XDN Transcriptional regulator AB180_04240 ENOG4107FW0 short-chain dehydrogenase reductase AB180_04255 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AB180_04275 ENOG4107SEY Conserved Protein AB180_04290 ENOG4108YXQ IS66 Orf2 family protein AB180_04295 ENOG4105E5H Transposase AB180_04320 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AB180_04430 ENOG4105Y50 Virulence Protein AB180_04440 ENOG4105D3W isochorismatase AB180_04445 ENOG4105C9M aspartyl-trna synthetase AB180_04450 ENOG4108TIT dATP pyrophosphohydrolase AB180_04460 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) AB180_04475 ENOG4105FAV ABC, transporter AB180_04485 ENOG4105NXV High-affinity zinc uptake system protein AB180_04490 ENOG4105DR5 peptidase AB180_04495 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AB180_04500 ENOG4105CA9 Pyruvate kinase AB180_04505 ENOG4106KNT transcriptional regulator AB180_04510 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AB180_04515 ENOG4105C01 Dihydroxy-acid dehydratase AB180_04520 ENOG4108UHU Aldolase AB180_04530 ENOG4105X2V dna damage-inducible protein AB180_04540 ENOG4108Q2J Inner membrane protein YebE AB180_04545 ENOG4105CUG Oligopeptidase b AB180_04550 ENOG4105UMD exodeoxyribonuclease X AB180_04555 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AB180_04560 ENOG4105MPK DNA polymerase III subunit theta AB180_04565 ENOG4105FXM Copper resistance protein AB180_04570 ENOG4108PNC copper resistance AB180_04575 ENOG4105NKT exported protein AB180_04580 ENOG4108R1E Serine threonine protein phosphatase 1 AB180_04585 ENOG4105UVW uncharacterized protein yebW AB180_04590 ENOG4105WT8 Protein of unknown function (DUF1480) AB180_04595 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AB180_04600 ENOG4105DY2 Paraquat-inducible protein b AB180_04605 ENOG4105H2K paraquat-inducible protein a AB180_04610 ENOG4108ZGC gaf domain protein AB180_04615 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) AB180_04620 ENOG4105CN1 protease AB180_04665 ENOG4108RBT type iii secretion AB180_04670 ENOG4106BTR AB180_04675 ENOG4105Y7Q type iii secretion AB180_04700 ENOG4105K44 type iii secretion AB180_04715 ENOG4108HR8 type iii secretion AB180_04720 ENOG4105REY Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone AB180_04725 ENOG4108JIR Flagellum-specific ATP synthase AB180_04740 ENOG4105CMM transposase AB180_04755 ENOG4105DD5 Flagellar motor switch protein AB180_04760 ENOG41075IY surface presentation of antigens protein SpaP AB180_04775 ENOG4108M6W surface presentation of antigens protein SpaS AB180_04785 ENOG41068CG regulatoR AB180_04800 ENOG4105C0R drug resistance transporter emrb qaca subfamily AB180_04805 ENOG4105J4Q Transcriptional regulator AB180_04810 ENOG4105TIK AB180_04815 ENOG4107BVS AB180_04820 ENOG4105Q3Y exported protein AB180_04825 ENOG4105VEQ Cold shock protein AB180_04830 ENOG4105CJN penicillin-binding protein AB180_04835 ENOG4105DHI Methyltransferase AB180_04845 ENOG4108NK4 UPF0266 membrane protein AB180_04850 ENOG4105F3R pts system mannose fructose sorbose family iid AB180_04855 ENOG4105ETZ PTS System AB180_04860 ENOG4108EQA pts system AB180_04865 ENOG4105EE5 Membrane protein terC AB180_04870 ENOG4107XTP (EAL) domain protein AB180_04875 ENOG4105EJQ L-serine dehydratase AB180_04885 ENOG4105CRQ synthase (Component I) AB180_04895 ENOG4105M4H endoribonuclease L-psp AB180_04900 ENOG4105DVT helicase AB180_04905 ENOG41072GX Peptidase M22 Glycoprotease AB180_04910 ENOG4105Y4Z Outer Membrane Lipoprotein AB180_04915 ENOG4105CEY Amp-dependent synthetase and ligase AB180_04920 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AB180_04925 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AB180_04930 ENOG4105EJC lysr family transcriptional regulator AB180_04940 ENOG4107QMS site-determining protein AB180_04950 ENOG4105VNG YcgL domain-containing protein AB180_04955 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AB180_04960 ENOG4108ZZ3 UPF0260 protein AB180_04985 ENOG4105ED1 spovr family AB180_04990 ENOG4105MWK D-amino acid dehydrogenase, small subunit AB180_04995 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AB180_05005 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AB180_05015 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) AB180_05030 ENOG4108PQF modD protein AB180_05040 ENOG4105E0A ABC, transporter AB180_05045 ENOG4105EHG Permease protein AB180_05050 ENOG4105S10 periplasmic binding protein AB180_05055 ENOG4105E53 ec 3.2.1.28 AB180_05065 ENOG4108UTZ Dihydroxyacetone kinase AB180_05070 ENOG4105CMT Dihydroxyacetone kinase AB180_05075 ENOG4105D82 Glutamate dehydrogenase AB180_05100 ENOG4108XDN Transcriptional regulator AB180_05105 ENOG4105BZU Histidine kinase AB180_05110 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component AB180_05115 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB AB180_05130 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AB180_05135 ENOG4105D7K pfkb domain protein AB180_05140 ENOG4108HKT sucrose-6-phosphate hydrolase AB180_05145 ENOG4106NDP Transcriptional regulator AB180_05150 ENOG4105C3G gtp-binding protein AB180_05160 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria AB180_05165 ENOG4105CFH Aspartokinase AB180_05170 ENOG4108JPW Aminotransferase AB180_05175 ENOG4105DY8 decarboxylase AB180_05180 ENOG4105CHH sulfate transporter AB180_05185 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AB180_05195 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) AB180_05205 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AB180_05210 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AB180_05215 ENOG4108YY7 Invasion gene expression up-regulator SirB AB180_05220 ENOG41063JG Transcriptional regulator AB180_05230 ENOG4105EWV Sodium calcium exchanger membrane region AB180_05235 ENOG4108NH8 Cation transport protein AB180_05245 ENOG41090EX DsrE family AB180_05250 ENOG4105ID0 Putative invasin AB180_05255 ENOG4105WH1 Two component transcriptional regulator luxr family AB180_05260 ENOG4105BZU Histidine kinase AB180_05265 ENOG4105DQQ Major facilitator superfamily MFS_1 AB180_05270 ENOG4105CRU nitrate reductase, alpha subunit AB180_05275 ENOG4108IUE nitrate reductase beta subunit AB180_05280 ENOG4105R3A Nitrate reductase AB180_05285 ENOG41076YT nitrate reductase, gamma subunit AB180_05300 ENOG4105CIY formyltetrahydrofolate deformylase AB180_05310 ENOG4105D78 K07001 NTE family protein AB180_05315 ENOG4105I93 response regulator AB180_05320 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AB180_05330 ENOG4107104 thymidine kinase AB180_05335 ENOG4108EKI Dehydrogenase AB180_05340 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AB180_05345 ENOG4107QSI ABC, transporter AB180_05350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AB180_05355 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AB180_05360 ENOG4105C3U ABC transporter AB180_05365 ENOG4108JQ7 (ABC) transporter AB180_05370 ENOG4105EYW Ion transport protein AB180_05380 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AB180_05385 ENOG4105K9H YciI-like protein AB180_05390 ENOG410822N TonB family AB180_05395 ENOG4105NAU thioesterase Superfamily protein AB180_05400 ENOG4107835 probably involved in intracellular septation (By similarity) AB180_05405 ENOG4108S3I UPF0259 membrane protein AB180_05410 ENOG4105EIF outer membrane protein W AB180_05415 ENOG4105CDY transcriptional regulatory protein AB180_05430 ENOG4105BZU Histidine kinase AB180_05435 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) AB180_05440 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AB180_05445 ENOG4105DK0 Indole-3-glycerol phosphate synthase AB180_05450 ENOG4108EFP Anthranilate synthase component II AB180_05455 ENOG4105CRQ synthase (Component I) AB180_05460 ENOG4105DB7 PHP domain protein AB180_05465 ENOG4107RTD sua5 ycio yrdc ywlc family protein AB180_05470 ENOG4105FE9 pseudouridine synthase AB180_05475 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AB180_05480 ENOG4105UBK short-chain dehydrogenase reductase AB180_05485 ENOG4105ERU peptidase AB180_05490 ENOG4105RKX Protein of unknown function (DUF2498) AB180_05495 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AB180_05500 ENOG4107R11 Transcriptional regulator AB180_05505 ENOG4107QM5 aconitate hydratase AB180_05510 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) AB180_05515 ENOG4105EYK Phosphatidylglycerophosphatase B AB180_05520 ENOG4105Q4A inner membrane protein yciS AB180_05525 ENOG4105CFV Tetratricopeptide repeat protein AB180_05535 ENOG4108ZJT translation initiation factor, Sui1 AB180_05540 ENOG41061RM osmotically inducible lipoprotein AB180_05545 ENOG4105N2W Transcriptional regulator AB180_05555 ENOG4105BZU Histidine kinase AB180_05565 ENOG4105Q4T oxidoreductase AB180_05570 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AB180_05580 ENOG4108JQ2 peptide transport system atp-binding protein AB180_05585 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AB180_05590 ENOG4108EU3 peptide transport system, permease AB180_05595 ENOG4108I5W peptide transport system, permease protein AB180_05600 ENOG4108J59 Extracellular solute-binding protein, family 5 AB180_05615 ENOG4105E51 psp operon transcriptional activator AB180_05620 ENOG41087YS Phage shock protein A AB180_05625 ENOG4105YYT phage shock protein B AB180_05630 ENOG4105FM1 phage shock protein C AB180_05635 ENOG4105NNG Peripheral inner membrane phage-shock protein AB180_05640 ENOG4107QW3 Sucrose phosphorylase AB180_05645 ENOG4105WEM extracellular solute-binding protein AB180_05650 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component AB180_05655 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AB180_05660 ENOG4107RRD Dehydrogenase AB180_05665 ENOG4107TYA transient receptor potential locus AB180_05670 ENOG4105CK5 oxidoreductase AB180_05675 ENOG4105C71 hydrolase family 65, central catalytic AB180_05680 ENOG4107URF beta-phospho-glucomutase AB180_05690 ENOG4107EFV Outer membrane protein G AB180_05695 ENOG4105FKQ transcriptional regulator AB180_05700 ENOG4105K8Z Phage shock protein AB180_05705 ENOG4105CM6 amino acid regulated cytosolic protein AB180_05710 ENOG4106K28 UPF0283 membrane protein AB180_05720 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AB180_05725 ENOG4107S8C mandelate racemase muconate lactonizing AB180_05730 ENOG4105KXI murein peptide amidase A AB180_05735 ENOG4107QSI ABC, transporter AB180_05755 ENOG4105MVE transcriptional regulator AB180_05760 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AB180_05770 ENOG4105DQ4 alcohol dehydrogenase AB180_05775 ENOG4105D64 Mechanosensitive ion channel AB180_05780 ENOG4105S5I Membrane AB180_05785 ENOG4105Q9Y Universal stress protein AB180_05795 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AB180_05800 ENOG4108DG9 Smr protein MutS2 AB180_05805 ENOG4105BZU Histidine kinase AB180_05810 ENOG4105BZU Histidine kinase AB180_05815 ENOG4105C8Q Methyl-accepting chemotaxis AB180_05825 ENOG4105C1J atp-dependent rna helicase AB180_05830 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) AB180_05835 ENOG4108RW8 Universal stress protein F AB180_05845 ENOG4105FCK Membrane AB180_05850 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AB180_05860 ENOG41090X5 Heat shock protein hslJ AB180_05865 ENOG4105C5I Dehydrogenase AB180_05870 ENOG4107H52 Dicarboxylate transport AB180_05875 ENOG410689M (LipO)protein AB180_05880 ENOG4105WXT Conserved Protein AB180_05890 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AB180_05895 ENOG4105CQ7 ATP-dependent helicase AB180_05900 ENOG4107DB1 DUF218 domain AB180_05905 ENOG4105C26 Dehydrogenase AB180_05915 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AB180_05920 ENOG4105CPW cytochrome b561 AB180_05925 ENOG4105KT5 UmuD protein AB180_05930 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AB180_05935 ENOG4108MG3 formate dehydrogenase AB180_05940 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AB180_05945 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_05950 ENOG4108KBJ Inner membrane protein YkgB AB180_05970 ENOG4105C8Q Methyl-accepting chemotaxis AB180_05995 ENOG4108VEV chaperone AB180_06005 ENOG4105DDW LysR family Transcriptional regulator AB180_06010 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AB180_06015 ENOG4105E32 cytoplasmic protein AB180_06025 ENOG4105Z2P Protein of unknown function (DUF465) AB180_06030 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AB180_06035 ENOG4108Z9I -acetyltransferase AB180_06040 ENOG4107WE3 acetyltransferase YdcK AB180_06045 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein AB180_06050 ENOG41088CC tellurite resistance protein tehB AB180_06055 ENOG4108KKZ (LipO)protein AB180_06060 ENOG4105DWP Membrane AB180_06070 ENOG4105DKK Benzoate AB180_06075 ENOG4108JCI Transcriptional regulator AB180_06080 ENOG4105CFP Peptidase U32 AB180_06090 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AB180_06095 ENOG4105C4M (Ubiquinol oxidase) subunit I AB180_06105 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AB180_06110 ENOG4107TYH extracellular solute-binding protein family 1 AB180_06115 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AB180_06120 ENOG4105D81 ABC transporter, permease AB180_06125 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component AB180_06130 ENOG4105C26 Dehydrogenase AB180_06150 ENOG4105DEF Extracellular solute-binding protein, family 5 AB180_06155 ENOG4105R71 cytoplasmic protein AB180_06160 ENOG4108T9Y Inner membrane protein ydcZ AB180_06165 ENOG4108Z7F N-acetyltransferase AB180_06175 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AB180_06180 ENOG4108NS2 receptor AB180_06185 ENOG4105SUV lipoprotein YgdR AB180_06190 ENOG4105C85 amino acid AB180_06195 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AB180_06200 ENOG4105DEN Luciferase family AB180_06205 ENOG4105CH2 amidohydrolase AB180_06215 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AB180_06230 ENOG4105CDA abc transporter atp-binding protein AB180_06240 ENOG4105CC0 LysR family Transcriptional regulator AB180_06245 ENOG4108N27 Glutathione S-transferase AB180_06260 ENOG4108MEJ flavin reductase domain protein AB180_06265 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AB180_06280 ENOG4105JAB phenazine biosynthesis protein, phzf family AB180_06285 ENOG4105D0D Nitrate reductase 2, gamma subunit AB180_06290 ENOG4108NZN Respiratory nitrate reductase 2 delta chain AB180_06295 ENOG4108IUE nitrate reductase beta subunit AB180_06300 ENOG4105CRU nitrate reductase, alpha subunit AB180_06305 ENOG4107QND Nitrite extrusion protein AB180_06330 ENOG4105RPH Inner membrane protein YddG AB180_06335 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_06340 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_06345 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AB180_06350 ENOG4108MG3 formate dehydrogenase AB180_06355 ENOG4105F0N pyrophosphate phospho-hydrolase AB180_06360 ENOG4105C5H ABC transporter AB180_06365 ENOG4107R1I NAD-dependent malic enzyme AB180_06370 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein AB180_06375 ENOG4108Z9K Osmotically inducible protein AB180_06380 ENOG4105DTD Dehydrogenase AB180_06385 ENOG4105CY2 Citrate transporter AB180_06390 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AB180_06395 ENOG4105CHU acetyl-coa acetyltransferase AB180_06400 ENOG4107QNJ CoA-transferase subunit B AB180_06405 ENOG4107QP7 CoA-transferase subunit A AB180_06410 ENOG4105DUM transcriptional regulator, lysR family AB180_06415 ENOG4107H6U ABC transporter AB180_06420 ENOG4105C3U ABC transporter AB180_06425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AB180_06430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AB180_06435 ENOG4105DEF Extracellular solute-binding protein, family 5 AB180_06440 ENOG4108UQS dipeptidase AB180_06450 ENOG4105XXV Acid-resistance protein AB180_06455 ENOG4105C8Q Methyl-accepting chemotaxis AB180_06475 ENOG4105F32 YngK protein AB180_06480 ENOG4105VYA Uncharacterized conserved protein (DUF2132) AB180_06485 ENOG4107QZV Type I secretion membrane fusion protein AB180_06490 ENOG4108JJ6 Type I secretion system ATPase AB180_06505 ENOG4108VEV chaperone AB180_06520 ENOG4105GQR Chaperone AB180_06535 ENOG4108YYQ gCN5-related N-acetyltransferase AB180_06550 ENOG4105FFC UPF0187 protein AB180_06555 ENOG4107QZW Altronate oxidoreductase AB180_06565 ENOG4105M0C cytoplasmic protein AB180_06570 ENOG4105CSV Glutaminase AB180_06575 ENOG4105C8Q Methyl-accepting chemotaxis AB180_06580 ENOG4105C26 Dehydrogenase AB180_06585 ENOG4105EGI Transcriptional regulator AB180_06590 ENOG4105F27 Major Facilitator AB180_06600 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AB180_06610 ENOG4106DNR multiple antibiotic resistance protein AB180_06615 ENOG4108594 Permease of the drug metabolite transporter AB180_06620 ENOG4105E5W Transporter AB180_06625 ENOG4108IV0 ABC, transporter AB180_06630 ENOG4105C2J ABC transporter AB180_06635 ENOG4105CNN ABC, transporter AB180_06640 ENOG4105C32 Amino acid ABC transporter (Permease) AB180_06655 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria AB180_06665 ENOG4105DGW oligopeptidase A AB180_06670 ENOG4105EMU Dehydrogenase AB180_06675 ENOG4107XBN GntR Family Transcriptional Regulator AB180_06680 ENOG41061EV selenium-binding protein YdfZ AB180_06685 ENOG4105DEI Mannitol dehydrogenase AB180_06695 ENOG4105CXK mandelate racemase muconate lactonizing AB180_06700 ENOG4105KK4 UPF0060 membrane protein AB180_06705 ENOG4105M5Q UPF0482 protein AB180_06710 ENOG4108MK9 spermidine N(1)-acetyltransferase AB180_06720 ENOG4105KBG Protein of unknown function (DUF1161) AB180_06725 ENOG4107QY8 reductase AB180_06730 ENOG4105QAX Iron-sulfur AB180_06735 ENOG4107KGK dmso reductase anchor subunit AB180_06740 ENOG4108NEM leader-binding protein dmsD AB180_06745 ENOG4105CMQ Chloride channel AB180_06750 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AB180_06755 ENOG4105DAG ROK family AB180_06760 ENOG4106NZI LysR family Transcriptional regulator AB180_06765 ENOG4105D94 Major Facilitator Superfamily AB180_06775 ENOG4105I8F Histidine kinase AB180_06780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AB180_06830 ENOG4108C33 Resolvase AB180_06840 ENOG4105CMM transposase AB180_06850 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AB180_06855 ENOG4105CTD carboxy-peptidase AB180_06865 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap AB180_06870 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) AB180_06880 ENOG4105DSF transport protein AB180_06885 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AB180_06890 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AB180_06895 ENOG4105C5D exported protein AB180_06900 ENOG4105D5Q Arginine ornithine antiporter AB180_06905 ENOG410642E Short chain dehydrogenase AB180_06910 ENOG4105RA2 Membrane AB180_06915 ENOG4107EXC regulatoR AB180_06920 ENOG4108ETY sodium dicarboxylate symporter AB180_06950 ENOG4105JJR Histidine kinase AB180_06955 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) AB180_06960 ENOG4105C9Q fumarate hydratase class II AB180_06965 ENOG4107GFK fumarate AB180_06970 ENOG4105EIP mannose-6-phosphate isomerase AB180_06975 ENOG4106J39 exported protein AB180_06980 ENOG4107P2S Transcriptional regulator AB180_06985 ENOG4105CI1 PTS System AB180_06990 ENOG4105C87 Aminotransferase class I and II AB180_07000 ENOG4105D9R oxidoreductase AB180_07005 ENOG4106C6R beta-lactam resistance protein AB180_07010 ENOG4105QZ5 OriC-binding nucleoid-associated protein AB180_07015 ENOG4105M9B inner membrane protein ydgK AB180_07025 ENOG4108R3D Electron transport complex AB180_07035 ENOG4105D6A Electron transport complex AB180_07040 ENOG4108UQQ Electron transport complex AB180_07045 ENOG4105DZB Electron transport complex AB180_07050 ENOG4105CSM endonuclease III AB180_07055 ENOG4105DUX Transporter AB180_07060 ENOG4108K3A Glutathione S-transferase AB180_07065 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AB180_07070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AB180_07080 ENOG410642K Lysozyme inhibitor AB180_07090 ENOG4108XTF Outer Membrane Lipoprotein AB180_07105 ENOG4105Y49 secretion protein, HlyD family AB180_07110 ENOG4105DSW Fusaric acid resistance protein AB180_07115 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AB180_07120 ENOG4107RGM aldo keto reductase AB180_07125 ENOG4105XZD Fe-S protein AB180_07130 ENOG4108WUH Transcriptional regulator, TetR family AB180_07135 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AB180_07140 ENOG4108UYE Lactoylglutathione lyase AB180_07145 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AB180_07150 ENOG4105M2J Glutaredoxin AB180_07155 ENOG4105K4H Nlp p60 protein AB180_07160 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AB180_07165 ENOG4105F27 Major Facilitator AB180_07170 ENOG4105ETE Transcriptional regulator (LacI family AB180_07175 ENOG4105F52 Transcriptional regulator AB180_07180 ENOG4105CZQ inner membrane transport protein YdhC AB180_07185 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AB180_07190 ENOG4108R6K riboflavin synthase, subunit alpha AB180_07200 ENOG4105D3G Pseudouridine synthase AB180_07205 ENOG4105JAB phenazine biosynthesis protein, phzf family AB180_07210 ENOG4105N0V mono-oxygenase ydhR AB180_07215 ENOG4105KME endoribonuclease L-psp AB180_07235 ENOG4105BZU Histidine kinase AB180_07240 ENOG4108V06 Glutathione peroxidase AB180_07245 ENOG4105F4G Membrane AB180_07260 ENOG4105CHR reductase AB180_07265 ENOG4105D29 Helix-turn-helix type 11 domain protein AB180_07280 ENOG4108S1B Periplasmic chaperone protein AB180_07285 ENOG4105E6S usher protein( AB180_07310 ENOG4108V06 Glutathione peroxidase AB180_07330 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein AB180_07335 ENOG4108W0P ABC transporter AB180_07340 ENOG4105EHG Permease protein AB180_07345 ENOG4105S10 periplasmic binding protein AB180_07350 ENOG4108JPW Aminotransferase AB180_07375 ENOG4105C26 Dehydrogenase AB180_07390 ENOG4105C85 amino acid AB180_07395 ENOG4105CT1 (ABC) transporter AB180_07405 ENOG4106YG3 ABC transporter AB180_07410 ENOG4105DRP amino acid AbC transporter AB180_07415 ENOG4108Y7C Conserved Protein AB180_07420 ENOG4108NWD Cytochrome AB180_07425 ENOG4108393 oxidoreductase Fe-S subunit AB180_07430 ENOG4105JVW AB180_07435 ENOG4105WE2 aldehyde ferredoxin oxidoreductase AB180_07440 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein AB180_07445 ENOG4105RFR Protein of unknown function (DUF2767) AB180_07450 ENOG4108ZXC Two component transcriptional regulator, luxr family AB180_07460 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AB180_07465 ENOG4106WHD Tetrathionate reductase AB180_07470 ENOG4105DB1 molybdopterin oxidoreductase AB180_07485 ENOG4105D01 (LipO)protein AB180_07490 ENOG4108UMI ABC transporter, permease AB180_07500 ENOG4108RVA ribokinase AB180_07515 ENOG4105CUB amino acid AB180_07520 ENOG4105CA9 Pyruvate kinase AB180_07530 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AB180_07540 ENOG4105C9B Cysteine desulfurase AB180_07545 ENOG4105JRK feS assembly protein SufD AB180_07550 ENOG4105C3K feS assembly ATPase SufC AB180_07555 ENOG4105DIW FeS assembly protein SUFB AB180_07560 ENOG4108Z4V iron-sulfur cluster assembly AB180_07565 ENOG4105EJC lysr family transcriptional regulator AB180_07575 ENOG410671Z uncharacterized protein ydiH AB180_07580 ENOG4105KA0 thioesterase Superfamily protein AB180_07585 ENOG4105CQB FAD linked oxidase domain protein AB180_07590 ENOG4105IPI Membrane AB180_07595 ENOG4105SUA Ydil protein AB180_07600 ENOG4105EMV Major Facilitator AB180_07605 ENOG4105EMV Major Facilitator AB180_07615 ENOG4105F2I Transposase AB180_07630 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) AB180_07635 ENOG4105C1G acyl-Coa dehydrogenase AB180_07640 ENOG4105W4W Transcriptional regulator AB180_07645 ENOG4105CV7 Electron transfer flavoprotein AB180_07650 ENOG4105C10 Electron transfer flavoprotein AB180_07655 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AB180_07660 ENOG41090P5 ferredoxin-like protein AB180_07665 ENOG4105CEY Amp-dependent synthetase and ligase AB180_07670 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AB180_07680 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AB180_07685 ENOG4106EDX Hemin uptake protein AB180_07690 ENOG4107ENK receptor AB180_07695 ENOG4106QJH hemin transport protein AB180_07700 ENOG4107R4I Periplasmic binding protein AB180_07705 ENOG4105EHG Permease protein AB180_07710 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) AB180_07725 ENOG4108QBX (LipO)protein AB180_07730 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) AB180_07735 ENOG4108V06 Glutathione peroxidase AB180_07745 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AB180_07760 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AB180_07765 ENOG41082NX 50s ribosomal protein l35 AB180_07770 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AB180_07780 ENOG4108NE3 Salt-induced outer membrane protein AB180_07785 ENOG4105DE4 1-phosphofructokinase AB180_07790 ENOG4105FGM Fructosamine kinase AB180_07795 ENOG4107PN8 YfeABCD locus regulator AB180_07800 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AB180_07805 ENOG4105CHR reductase AB180_07810 ENOG4107K5X Membrane-bound metal-dependent hydrolase AB180_07815 ENOG4108ETY sodium dicarboxylate symporter AB180_07820 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) AB180_07825 ENOG4105CH6 catalase AB180_07830 ENOG410901P UPF0249 protein AB180_07835 ENOG4105F8D glycoside hydrolase family 4 AB180_07840 ENOG4105EZV Transcriptional regulator AB180_07845 ENOG4105VCP PTS System AB180_07850 ENOG4105CK1 PTS System AB180_07855 ENOG4105VZJ PTS System AB180_07860 ENOG4105KKI DNA-binding transcriptional activator OsmE AB180_07865 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AB180_07870 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) AB180_07875 ENOG41090B9 response to stress AB180_07880 ENOG4108SPG Periplasmic Protein AB180_07885 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) AB180_07890 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) AB180_07895 ENOG4105C26 Dehydrogenase AB180_07900 ENOG4105F4X arginine AB180_07905 ENOG4105C8Y Acetylornithine aminotransferase AB180_07910 ENOG4105CGK Exodeoxyribonuclease III AB180_07915 ENOG4108RSN SNARE associated Golgi AB180_07920 ENOG4108N5C SNARE associated Golgi protein-related protein AB180_07925 ENOG4105VNH ABC transporter solute-binding protein AB180_07930 ENOG4105CXZ ABC transporter, permease AB180_07935 ENOG4108VGW abc transporter atp-binding protein AB180_07940 ENOG4107RM6 sulfurtransferase AB180_07945 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AB180_07950 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AB180_07955 ENOG4105M6F mutator MutT protein AB180_07960 ENOG4105MTM Protein of unknown function (DUF1496) AB180_07965 ENOG4105D82 Glutamate dehydrogenase AB180_07970 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AB180_07975 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) AB180_07980 ENOG41069NU Nitroreductase AB180_07985 ENOG4105D07 Signal peptide peptidase, SppA AB180_07990 ENOG4105HDK L-asparaginase AB180_07995 ENOG4108RWI nicotinamidase AB180_08000 ENOG4108KUU Inner membrane metabolite transport protein ydjE AB180_08005 ENOG4105E98 transcriptional regulator DeoR family AB180_08010 ENOG4105CPC Aldo Keto reductase AB180_08015 ENOG4107UH8 sugar kinase AB180_08020 ENOG4105D2N Aldolase AB180_08025 ENOG4105CPQ Dehydrogenase AB180_08030 ENOG4107TE1 transport protein AB180_08035 ENOG4105CPQ Dehydrogenase AB180_08045 ENOG4105N1F Hnh endonuclease AB180_08050 ENOG4105VUT cytoplasmic protein AB180_08060 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AB180_08065 ENOG4105DSB aldose 1-epimerase AB180_08070 ENOG4105CV8 reductase AB180_08075 ENOG4105GNX MltA-interacting MipA family protein AB180_08080 ENOG4105CYN Serine protein kinase AB180_08090 ENOG4105DVA methyltransferase AB180_08095 ENOG4108KHP Diguanylate cyclase AB180_08100 ENOG4108KXH Ybak prolyl-tRNA synthetase associated AB180_08110 ENOG4105R1U AraC Family Transcriptional Regulator AB180_08115 ENOG4105DJ2 Major Facilitator Superfamily AB180_08120 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AB180_08125 ENOG4105K78 MarR family Transcriptional regulator AB180_08130 ENOG4105UCG Domain of unknown function (DUF333) AB180_08135 ENOG410620I Diguanylate cyclase AB180_08140 ENOG4105Y3U Transglycosylase-associated protein AB180_08145 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_08155 ENOG4105YP6 Domain of unknown function (DUF1869) AB180_08160 ENOG4108YS1 cytoplasmic protein AB180_08165 ENOG4108NIW Leucine export protein LeuE AB180_08170 ENOG4108MEK Metal-binding protein YodA AB180_08175 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) AB180_08185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AB180_08195 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AB180_08200 ENOG4105D05 Receptor AB180_08205 ENOG4108QD8 lipopolysaccharide core biosynthesis protein AB180_08215 ENOG4105BZU Histidine kinase AB180_08245 ENOG4108T1M outer membrane protein x AB180_08265 ENOG4105CAU Arsenical resistance protein, ArsH AB180_08270 ENOG4105Y50 Virulence Protein AB180_08280 ENOG4108HMX isocitrate dehydrogenase (NADP) AB180_08285 ENOG4108R99 pseudouridine synthase AB180_08300 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AB180_08310 ENOG4107QTF adenylosuccinate lyase AB180_08315 ENOG4108RAV Conserved protein AB180_08330 ENOG4105E5H Transposase AB180_08335 ENOG4108YXQ IS66 Orf2 family protein AB180_08355 ENOG4105CMM transposase AB180_08360 ENOG4106050 phage regulatory protein, rha family AB180_08385 ENOG4105NVB glycoside hydrolase, family 19 AB180_08415 ENOG4108MXB Protein of unknown function (DUF968) AB180_08430 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AB180_08450 ENOG4105YQ0 AB180_08455 ENOG4108S1U AB180_08530 ENOG4107R08 Integrase AB180_08535 ENOG41081XQ Conserved Protein AB180_08540 ENOG4105WJG Glutathione AB180_08550 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) AB180_08555 ENOG4106N3A copper homeostasis protein cutc AB180_08560 ENOG4106ZCM YecM protein AB180_08575 ENOG4105F5H Glycosyl Hydrolase Family 88 AB180_08580 ENOG4105IRD Flagellar protein FlhE AB180_08585 ENOG4105D7B Flagellar biosynthesis protein flha AB180_08590 ENOG4105D00 flagellar biosynthetic protein flhB AB180_08595 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AB180_08600 ENOG4108VYJ response regulator receiver protein AB180_08610 ENOG4105BZU Histidine kinase AB180_08615 ENOG4105C8Q Methyl-accepting chemotaxis AB180_08620 ENOG4105C8Q Methyl-accepting chemotaxis AB180_08625 ENOG4107QJT sodium dicarboxylate symporter AB180_08635 ENOG4108V3W Chemotaxis protein, CheW AB180_08640 ENOG4105CBS Chea signal transduction histidine kinase AB180_08645 ENOG4105ER2 Ompa motb domain protein AB180_08650 ENOG4107RD7 Flagellar Motor Protein, MotA AB180_08655 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region AB180_08665 ENOG4108VA4 Universal stress protein AB180_08670 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase AB180_08675 ENOG4108K4C ec 3.1.3.12 AB180_08680 ENOG4105CNN ABC, transporter AB180_08685 ENOG4105C2J ABC transporter AB180_08690 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator AB180_08700 ENOG4108UEC Ferritin-like protein AB180_08705 ENOG4105N4N Protein of unknown function (DUF2766) AB180_08710 ENOG4105C0R drug resistance transporter emrb qaca subfamily AB180_08720 ENOG4105P23 (LipO)protein AB180_08725 ENOG41090A1 ferritin AB180_08730 ENOG4105VVZ metal-binding protein AB180_08735 ENOG4105E0U tyrosine-specific transport protein AB180_08740 ENOG4106RHG Yeca family AB180_08745 ENOG410681U heavy metal transport detoxification protein AB180_08755 ENOG4108KS2 transglutaminase domain protein AB180_08795 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AB180_08800 ENOG4105WH1 Two component transcriptional regulator luxr family AB180_08805 ENOG4105XVG cytoplasmic protein AB180_08810 ENOG4105VJY transcriptional regulator AB180_08815 ENOG4105CDA abc transporter atp-binding protein AB180_08820 ENOG4105E5Q amino acid AbC transporter AB180_08830 ENOG4105EAB amino acid AbC transporter AB180_08835 ENOG4108M9K flagella biosynthesis protein FliZ AB180_08840 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AB180_08845 ENOG4105I03 Flagellin AB180_08850 ENOG4105DTS flagellar hook-associated AB180_08855 ENOG4105MQ3 flagellar protein FliS AB180_08865 ENOG4105E5K Alpha-amylase AB180_08870 ENOG4105JCU Inherit from NOG: (Lipo)protein AB180_08875 ENOG41066VF YeeE YedE family protein AB180_08880 ENOG4105KSU Redox protein AB180_08895 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AB180_08900 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AB180_08905 ENOG41090PJ Flagellar assembly protein AB180_08910 ENOG4108JIR Flagellum-specific ATP synthase AB180_08915 ENOG4105GSA Flagellar export protein flij AB180_08920 ENOG4105WF4 Flagellar hook-length control protein AB180_08925 ENOG4107ZI8 flagellar basal body-associated protein flil AB180_08930 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AB180_08935 ENOG4105DD5 Flagellar motor switch protein AB180_08940 ENOG4105K0P flagellar biosynthesis protein AB180_08945 ENOG4105CN7 Flagellar biosynthetic protein FliP AB180_08950 ENOG4105VS8 Flagellar biosynthetic protein fliq AB180_08955 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AB180_08960 ENOG4107TKS colanic acid capsular biosynthesis activation protein A AB180_08965 ENOG4105VZF DsrB protein AB180_08970 ENOG4105YX3 cellular response to acidity AB180_08975 ENOG4105VNZ cytoplasmic protein AB180_08980 ENOG4105CKW Inner membrane protein yedI AB180_08985 ENOG4105FDR Membrane AB180_08990 ENOG41090BB DNA mismatch endonuclease (vsr) AB180_08995 ENOG4105DVF Cytosine-specific methyltransferase AB180_09000 ENOG4105EST Metal Dependent Phosphohydrolase AB180_09005 ENOG4105FCK Membrane AB180_09010 ENOG410814C multidrug resistance protein AB180_09035 ENOG4107RCV ABC transporter, permease AB180_09040 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AB180_09045 ENOG4108PXI ErfK YbiS YcfS YnhG AB180_09050 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) AB180_09055 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) AB180_09060 ENOG4108YZT Adenosylcobinamide kinase AB180_09065 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AB180_09075 ENOG4108V4M Cobalt abc transporter AB180_09080 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AB180_09085 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) AB180_09090 ENOG4105DVK Precorrin-2 c20-methyltransferase AB180_09095 ENOG4107PPM cobalt chelatase AB180_09100 ENOG4105QUC reductase AB180_09105 ENOG4105E4R Precorrin-3B C17-methyltransferase AB180_09110 ENOG4108P62 biosynthesis protein (CbiG) AB180_09115 ENOG4105CIA precorrin-4 C(11)-methyltransferase AB180_09120 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase AB180_09125 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase AB180_09130 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) AB180_09135 ENOG41081F0 Precorrin-8x methylmutase AB180_09140 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) AB180_09145 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) AB180_09150 ENOG4107XVH Transcriptional regulator AB180_09155 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AB180_09160 ENOG4105KNY Microcompartments protein AB180_09165 ENOG4105EHR propanediol utilization protein pduB AB180_09170 ENOG4105DMB glycerol dehydratase AB180_09175 ENOG4105YCI dehydratase medium subunit AB180_09180 ENOG4108ZFT Dehydratase small subunit AB180_09185 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit AB180_09195 ENOG4105KNY Microcompartments protein AB180_09205 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) AB180_09215 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml AB180_09225 ENOG4108EKI Dehydrogenase AB180_09235 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) AB180_09245 ENOG4105M3W utilization protein AB180_09250 ENOG4105KTW ethanolamine utilization protein AB180_09255 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AB180_09260 ENOG4105JZC GHMP kinase AB180_09270 ENOG4105DR8 Membrane AB180_09275 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) AB180_09280 ENOG4105DZ1 carboxypeptidase AB180_09285 ENOG4108NWD Cytochrome AB180_09290 ENOG4105QAX Iron-sulfur AB180_09295 ENOG4108J2R molybdopterin oxidoreductase AB180_09305 ENOG4105CJB Exodeoxyribonuclease I AB180_09310 ENOG4105CUB amino acid AB180_09315 ENOG4105EQ1 Transcriptional regulator AB180_09320 ENOG4108535 NAD dependent epimerase/dehydratase family AB180_09330 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AB180_09335 ENOG4105CIH Imidazole acetol-phosphate transaminase AB180_09345 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AB180_09350 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AB180_09360 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AB180_09365 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) AB180_09380 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AB180_09385 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AB180_09390 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AB180_09395 ENOG4105C1B dTDP-glucose 4-6-dehydratase AB180_09400 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AB180_09405 ENOG4105D3Q Sugar transferase AB180_09410 ENOG4108KBE Glycosyl transferase, family 2 AB180_09415 ENOG4108TMJ glycosyl transferase AB180_09420 ENOG4108SHN Glycosyl transferase, family 2 AB180_09430 ENOG4108MX3 Polysaccharide Biosynthesis Protein AB180_09435 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AB180_09440 ENOG4105G1A colanic acid biosynthesis protein AB180_09445 ENOG4107T8Q Glycosyl transferase (Group 1 AB180_09450 ENOG4105C74 pyruvyl transferase AB180_09455 ENOG4105PSV Polysaccharide Biosynthesis Protein AB180_09460 ENOG4105D3Q Sugar transferase AB180_09465 ENOG4107QKV phosphomannomutase AB180_09470 ENOG4105CJT Mannose-1-phosphate guanylyltransferase AB180_09475 ENOG4106CD9 glycosyl transferase group 1 AB180_09480 ENOG4105FGF GDP-mannose mannosyl hydrolase AB180_09485 ENOG4105C30 Nad-dependent epimerase dehydratase AB180_09490 ENOG4105C0K Gdp-mannose 4,6-dehydratase AB180_09495 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF AB180_09500 ENOG4105ECJ Glycosyl Transferase AB180_09505 ENOG4108NYJ Colanic acid AB180_09510 ENOG4107RXY Glycosyl transferase AB180_09515 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB AB180_09520 ENOG41090RK glycosyl transferase AB180_09525 ENOG4105D75 Capsular exopolysaccharide family AB180_09530 ENOG4105KJF protein tyrosine phosphatase AB180_09535 ENOG4105DAY polysaccharide export protein AB180_09540 ENOG4105EE5 Membrane protein terC AB180_09545 ENOG4108GAE asmA family AB180_09550 ENOG4105DHP deoxycytidine triphosphate deaminase AB180_09560 ENOG4105BZU Histidine kinase AB180_09565 ENOG4105D03 DNA-3-methyladenine glycosylase II AB180_09570 ENOG4105R8A Heat shock protein AB180_09580 ENOG4105BZS acriflavin resistance protein AB180_09585 ENOG4105BZS acriflavin resistance protein AB180_09590 ENOG4105C0R drug resistance transporter emrb qaca subfamily AB180_09595 ENOG4105EB3 Histidine kinase AB180_09600 ENOG4105E3W Two component transcriptional regulator (Winged helix family AB180_09605 ENOG4105KWI UPF0339 protein AB180_09610 ENOG4105CFP Peptidase U32 AB180_09615 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AB180_09620 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) AB180_09625 ENOG4105VEQ Cold shock protein AB180_09635 ENOG4105DJY efflux transporter, rnd family, mfp subunit AB180_09640 ENOG4108MJ5 VirK protein AB180_09645 ENOG4105CPB ATP-dependent endonuclease of the OLD family AB180_09650 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AB180_09655 ENOG4105DWU Membrane AB180_09665 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AB180_09670 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain AB180_09680 ENOG4105C7K acetolactate synthase AB180_09685 ENOG4105C5W Aldolase AB180_09690 ENOG4105CGD Nad-dependent epimerase dehydratase AB180_09695 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AB180_09700 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AB180_09710 ENOG41064MM (LipO)protein AB180_09715 ENOG4105E5Z arginine transporter ATP-binding subunit AB180_09720 ENOG4106PMH Extracellular solute-binding protein family 3 AB180_09725 ENOG4105GBT ABC transporter AB180_09730 ENOG4105DMR ABC, transporter AB180_09735 ENOG4106TNF Periplasmic binding protein AB180_09740 ENOG4107TE5 Lipid kinase AB180_09745 ENOG4105EIE fructose-bisphosphate aldolase AB180_09750 ENOG4105EAA nucleoside AB180_09755 ENOG4108KD5 ADP-ribosylation crystallin J1 AB180_09760 ENOG4108TFM Kinase, PfkB family AB180_09765 ENOG4105FDP GntR family transcriptional regulator AB180_09770 ENOG4105DWF phosphomethylpyrimidine kinase AB180_09775 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase AB180_09875 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly AB180_09885 ENOG4105CW0 outer membrane usher protein AB180_09890 ENOG4108MQF Chaperone AB180_09905 ENOG4105D1F ATP-binding protein AB180_09915 ENOG4108YCW (LipO)protein AB180_09920 ENOG4108W15 Protein of unknown function (DUF1456) AB180_09925 ENOG4108NEV two component transcriptional regulator, LytTR family AB180_09930 ENOG4108HRK Histidine kinase AB180_09935 ENOG4108XDN Transcriptional regulator AB180_09940 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component AB180_09945 ENOG4108IJ8 ABC transporter AB180_09950 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component AB180_09955 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AB180_09960 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AB180_09965 ENOG4105CXG d-lactate dehydrogenase AB180_09970 ENOG41061WM D-Alanyl-D-Alanine AB180_09975 ENOG41069YE inner membrane protein yohC AB180_09980 ENOG4105KHU inner membrane protein YohD AB180_09985 ENOG4105ETP RND efflux system, outer membrane lipoprotein AB180_09995 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AB180_10000 ENOG4105MSY salicylate hydroxylase AB180_10005 ENOG4108RXX maleylacetoacetate isomerase AB180_10030 ENOG4105VAW lrga family AB180_10035 ENOG41067MG lrgb family AB180_10040 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) AB180_10045 ENOG4107GZ4 SanA protein AB180_10050 ENOG4105Y9N Membrane AB180_10055 ENOG4105BZ8 glutamate synthase AB180_10060 ENOG4107SJI Dehydrogenase AB180_10065 ENOG4107SDZ Galactoside transport system permease protein mglC AB180_10070 ENOG4105C2J ABC transporter AB180_10080 ENOG41060NJ transcriptional regulator AB180_10085 ENOG4105DHF Membrane AB180_10090 ENOG4105EUJ GTP cyclohydrolase i AB180_10105 ENOG4105EJQ L-serine dehydratase AB180_10110 ENOG4105EAC phosphoserine phosphatase AB180_10115 ENOG4105CXY transporter AB180_10120 ENOG4105D05 Receptor AB180_10125 ENOG4108IQI permease AB180_10130 ENOG4105DUM transcriptional regulator, lysR family AB180_10135 ENOG4105HMI Membrane AB180_10145 ENOG4105DD7 kinase (PfkB family AB180_10150 ENOG4105D9N nucleoside AB180_10155 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AB180_10160 ENOG4105DD7 kinase (PfkB family AB180_10165 ENOG4107YNJ LysR family Transcriptional regulator AB180_10175 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AB180_10180 ENOG4105DM4 PTS System AB180_10185 ENOG4105DE4 1-phosphofructokinase AB180_10190 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AB180_10200 ENOG4105S8Q sugar efflux transporter AB180_10205 ENOG4105KRS Proteinase inhibitor AB180_10210 ENOG4107TII Recombinase AB180_10245 ENOG4105PGM cation diffusion facilitator family transporter AB180_10265 ENOG4108YXQ IS66 Orf2 family protein AB180_10270 ENOG4105E5H Transposase AB180_10285 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AB180_10290 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AB180_10295 ENOG4108EM1 reductase AB180_10300 ENOG4105CUW cytochrome C-TYPE protein AB180_10305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AB180_10310 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AB180_10315 ENOG4105DEI Mannitol dehydrogenase AB180_10320 ENOG4105CKI cobalamin synthesis protein AB180_10325 ENOG41076MN Phosphoesterase, PA-phosphatase related AB180_10330 ENOG4107TT5 NLP P60 protein AB180_10335 ENOG4105CXC rtn protein AB180_10340 ENOG4105E43 Extracellular solute-binding protein, family 5 AB180_10345 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AB180_10350 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AB180_10355 ENOG4108JQ5 ABC transporter AB180_10360 ENOG4105HG6 AB180_10365 ENOG4105C2C drug resistance transporter, Bcr CflA AB180_10370 ENOG4105I08 Pseudouridine synthase AB180_10375 ENOG4105CFI type iii restriction protein res subunit AB180_10380 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AB180_10385 ENOG4106V8H Nucleoid-associated protein AB180_10390 ENOG4105PAN UPF0352 protein AB180_10395 ENOG4105E68 Sulfatase AB180_10415 ENOG4105Y50 Virulence Protein AB180_10420 ENOG4108SEH involved in lipopolysaccharide biosynthesis AB180_10430 ENOG4105WH1 Two component transcriptional regulator luxr family AB180_10435 ENOG4105KWW Biogenesis protein AB180_10440 ENOG4107QX9 Thiol disulfide interChange protein AB180_10445 ENOG4105DA4 cytochrome c-type biogenesis protein AB180_10450 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) AB180_10455 ENOG4105X3C heme exporter protein AB180_10460 ENOG41060IM Heme exporter protein AB180_10465 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AB180_10470 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AB180_10475 ENOG4105CUW cytochrome C-TYPE protein AB180_10480 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) AB180_10485 ENOG4105GXZ Ferredoxin-type protein NapH AB180_10490 ENOG4108BGM Quinol dehydrogenase periplasmic component AB180_10495 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_10500 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase AB180_10505 ENOG4108ZNS ferredoxin-type protein NapF AB180_10515 ENOG4105DWT malate dehydrogenase (quinone) AB180_10520 ENOG4105CHH sulfate transporter AB180_10525 ENOG4105CJW magnesium transporter AB180_10530 ENOG4105IBP Cyclic peptide transporter AB180_10535 ENOG4105CF1 Alkylated DNA repair protein AB180_10540 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AB180_10545 ENOG4105CJ2 (LipO)protein AB180_10555 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC AB180_10560 ENOG41068CG regulatoR AB180_10565 ENOG4105BZU Histidine kinase AB180_10570 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AB180_10575 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) AB180_10580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AB180_10585 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AB180_10590 ENOG4105XPH Ferredoxin AB180_10595 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AB180_10600 ENOG4105CXY transporter AB180_10605 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A AB180_10610 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B AB180_10615 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AB180_10630 ENOG4108UII YfaZ family AB180_10635 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) AB180_10675 ENOG4106GZG polymyxin resistance protein B AB180_10680 ENOG4105CEY Amp-dependent synthetase and ligase AB180_10690 ENOG4108IPT Naphthoate synthase AB180_10695 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AB180_10705 ENOG4105E4F Isochorismate synthase AB180_10710 ENOG4105TNS Conserved Protein AB180_10715 ENOG4107YB6 acetyltransferase, (GNAT) family AB180_10720 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AB180_10725 ENOG4107R88 Chemotaxis protein (CheV) AB180_10730 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AB180_10735 ENOG4105C8S subunit m AB180_10740 ENOG4105D65 subunit l AB180_10745 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AB180_10750 ENOG4107UFS subunit j AB180_10760 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) AB180_10765 ENOG4107R0R NADH dehydrogenase subunit g AB180_10770 ENOG4107QIZ NADH dehydrogenase AB180_10775 ENOG4105GKE subunit e AB180_10780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AB180_10795 ENOG4107NQ8 LysR family Transcriptional regulator AB180_10800 ENOG4105CHM Aminotransferase AB180_10805 ENOG4105DK2 UPF0207 protein AB180_10810 ENOG4107QWE )-transporter AB180_10815 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AB180_10825 ENOG4105PQ6 UPF0208 membrane protein AB180_10830 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AB180_10835 ENOG4105C6K Malic enzyme AB180_10840 ENOG4105CSX c4-dicarboxylate anaerobic carrier AB180_10845 ENOG4105PTV Nudix Hydrolase AB180_10850 ENOG4108RE9 Phosphodiesterase AB180_10855 ENOG4108SHQ Glutathione S-transferase AB180_10860 ENOG4105CYM Glutathione S-transferase AB180_10865 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase AB180_10870 ENOG4105ECP epimerase AB180_10875 ENOG4105D9U N-acetyltransferase AB180_10880 ENOG4108JEH abc transporter atp-binding protein AB180_10885 ENOG4106YG3 ABC transporter AB180_10890 ENOG4105DSP amino acid AbC transporter AB180_10895 ENOG4105E89 ABC transporter AB180_10900 ENOG4105E89 ABC transporter AB180_10905 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AB180_10910 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AB180_10915 ENOG4105E96 Colicin v production protein AB180_10920 ENOG4108S3P Sporulation domain protein AB180_10925 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AB180_10935 ENOG4105DQR SNARE associated Golgi AB180_10945 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AB180_10950 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AB180_10955 ENOG4106WZ1 flagella biosynthesis regulator AB180_10960 ENOG4105F9N Major Facilitator Superfamily AB180_10965 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AB180_10970 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AB180_10975 ENOG4105MH2 YfcL protein AB180_10980 ENOG4108BPE -transporting atpase AB180_10985 ENOG4105EJ9 Membrane AB180_10990 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) AB180_11000 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AB180_11005 ENOG4108DG9 Smr protein MutS2 AB180_11010 ENOG4108BY2 phosphohistidine phosphatase AB180_11015 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AB180_11020 ENOG4105CHU acetyl-coa acetyltransferase AB180_11025 ENOG4105KZW UPF0381 protein AB180_11030 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AB180_11035 ENOG410903C (LipO)protein AB180_11040 ENOG4105S64 Formate nitrite transporter AB180_11055 ENOG4105C8Q Methyl-accepting chemotaxis AB180_11060 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AB180_11065 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta AB180_11075 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC AB180_11080 ENOG4105CXY transporter AB180_11085 ENOG4105W9M Membrane AB180_11090 ENOG4105D1S lipid A biosynthesis AB180_11100 ENOG4105CHM Aminotransferase AB180_11105 ENOG4108HRK Histidine kinase AB180_11110 ENOG4105DY9 regulatoR AB180_11115 ENOG4108CIP transcriptional regulator AB180_11125 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AB180_11130 ENOG4105CN9 Peptidase m42 family protein AB180_11135 ENOG4105DC7 peptidase M24 AB180_11140 ENOG410863U PTS System AB180_11145 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) AB180_11150 ENOG4105CHC glucokinase (EC 2.7.1.2) AB180_11160 ENOG4107RA9 decarboxylase AB180_11165 ENOG4105CPC Aldo Keto reductase AB180_11170 ENOG4109076 Conserved Protein AB180_11175 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AB180_11180 ENOG4105D9N nucleoside AB180_11195 ENOG4105HZG regulatoR AB180_11200 ENOG4105GXM Putative transcription regulator (DUF1323) AB180_11205 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AB180_11230 ENOG4105CN8 Transcriptional regulator AB180_11235 ENOG4105EAA nucleoside AB180_11240 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AB180_11245 ENOG4108NFH Sugar hydrolase AB180_11250 ENOG4108M0I Transcriptional regulator AB180_11255 ENOG4105DHU Bile acid AB180_11260 ENOG4105VRT cytoplasmic protein AB180_11265 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AB180_11275 ENOG4105EXN Sulfate transport protein CysZ AB180_11280 ENOG4105C6T cysteine synthase AB180_11285 ENOG4105KZ7 phosphocarrier protein hpr AB180_11295 ENOG4105C5Y PTS System AB180_11310 ENOG4105CSW GntR family transcriptional regulator AB180_11315 ENOG41089BK Glutamine amido-transferase AB180_11320 ENOG4105C6T cysteine synthase AB180_11325 ENOG4108IJ6 ABC transporter AB180_11330 ENOG4105ECW sulfate abc transporter AB180_11335 ENOG4108I5D sulfate abc transporter AB180_11340 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AB180_11345 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AB180_11350 ENOG4105EZR dyp-type peroxidase family protein AB180_11355 ENOG4105E7K (LipO)protein AB180_11360 ENOG4105QZU Inner membrane protein YfeZ AB180_11370 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase AB180_11380 ENOG4108K3Z AraC family transcriptional regulator AB180_11385 ENOG4108X49 Ethanolamine utilization protein EutK AB180_11390 ENOG4106D67 ethanolamine utilization protein AB180_11400 ENOG4105CPD ethanolamine ammonia-lyase AB180_11405 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase AB180_11410 ENOG4105ENY Ethanolamine utilization protein eutH AB180_11415 ENOG4105C0A alcohol dehydrogenase AB180_11420 ENOG4107RWI ethanolamine utilization protein eutJ AB180_11425 ENOG4108EKI Dehydrogenase AB180_11430 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml AB180_11435 ENOG4105KNY Microcompartments protein AB180_11440 ENOG4108IJ2 phosphate acetyltransferase AB180_11445 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase AB180_11450 ENOG4105NDK ethanolamine utilization protein AB180_11455 ENOG4106S4J ethanolamine utilization protein EutP AB180_11460 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place AB180_11465 ENOG4105C6K Malic enzyme AB180_11470 ENOG4105CV1 Transketolase (EC 2.2.1.1) AB180_11475 ENOG4108PVD exported protein AB180_11485 ENOG4105BZ8 glutamate synthase AB180_11490 ENOG4105BZU Histidine kinase AB180_11495 ENOG4105BZS acriflavin resistance protein AB180_11500 ENOG4105KUZ arsenate reductase AB180_11505 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) AB180_11510 ENOG4105XYK UPF0370 protein AB180_11515 ENOG4106KED esterase YpfH AB180_11520 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AB180_11525 ENOG4105CGZ zinc metallopeptidase AB180_11530 ENOG4105C8V SAICAR synthetase AB180_11535 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AB180_11545 ENOG4105RH4 Glycine cleavage system transcriptional repressor AB180_11550 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AB180_11555 ENOG4105DYB Isoaspartyl dipeptidase AB180_11560 ENOG4108P2H Inner membrane protein YjiG AB180_11565 ENOG41074DU domain protein AB180_11570 ENOG4105C02 permease AB180_11575 ENOG4105ERG peptidase m48, ste24p AB180_11580 ENOG4105K89 arsenate reductase AB180_11585 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) AB180_11590 ENOG4105C2W permease AB180_11600 ENOG4105CS2 ec 3.2.1.21 AB180_11610 ENOG4108V3E phosphoribosylglycinamide formyltransferase AB180_11615 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AB180_11620 ENOG4105C9X ppx gppa phosphatase AB180_11625 ENOG4105BZU Histidine kinase AB180_11635 ENOG4105D64 Mechanosensitive ion channel AB180_11665 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AB180_11690 ENOG4105VPD cellular component movement AB180_11700 ENOG4105DUX Transporter AB180_11705 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AB180_11710 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AB180_11715 ENOG4105N21 Membrane AB180_11725 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AB180_11730 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) AB180_11735 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AB180_11745 ENOG4108JQB penicillin-binding protein 1C AB180_11750 ENOG4105DN3 alpha-2-macroglobulin domain protein AB180_11755 ENOG4105KHC sulfurtransferase AB180_11760 ENOG4105YYA enhanced serine sensitivity protein SseB AB180_11765 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AB180_11770 ENOG4105WVQ Fe-S assembly protein IscX AB180_11775 ENOG4108ZIT Ferredoxin, 2FE-2S AB180_11795 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AB180_11800 ENOG4105C3J Cysteine desulfurase AB180_11805 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AB180_11810 ENOG4105CVS RNA methyltransferase TrmH family, group 1 AB180_11815 ENOG4105ECY inositol monophosphatase AB180_11820 ENOG4105D7X high-affinity nickel-transporter AB180_11825 ENOG41065CD Exported protein AB180_11835 ENOG4105C2J ABC transporter AB180_11840 ENOG4105CNN ABC, transporter AB180_11850 ENOG4105EF1 ribulokinase AB180_11855 ENOG4105C2X Arabinose 5-phosphate isomerase AB180_11860 ENOG4108MN2 Stationary phase inducible protein CsiE AB180_11865 ENOG4105D8G Major Facilitator superfamily AB180_11875 ENOG4107QNK )-transporter AB180_11885 ENOG4108NZE NAGC-like transcriptional regulator AB180_11890 ENOG4108W5M transcriptional regulator AB180_11895 ENOG4105FUY alpha subunit AB180_11920 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AB180_11925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AB180_11930 ENOG4108YZA Nitrogen regulatory protein pii AB180_11935 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AB180_11940 ENOG4108SKK alpha helix protein AB180_11945 ENOG4107WP9 Histidine kinase AB180_11955 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) AB180_11960 ENOG4108Z6B deaminase AB180_11965 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB AB180_11975 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AB180_11980 ENOG4106G6Q Transcriptional regulator AB180_11985 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AB180_11990 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AB180_11995 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AB180_12005 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AB180_12015 ENOG4105C3F Signal peptidase i AB180_12025 ENOG4105WMJ Positive regulator of sigma E, RseC MucC AB180_12030 ENOG4105VQK sigma E regulatory protein, MucB RseB AB180_12035 ENOG41069PW sigma-e factor negative regulatory protein AB180_12040 ENOG4105EMN RNA polymerase sigma factor AB180_12045 ENOG4108IYU L-aspartate oxidase AB180_12055 ENOG4105C1J atp-dependent rna helicase AB180_12075 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AB180_12080 ENOG4105EIB trna rrna methyltransferase AB180_12085 ENOG4105K63 Thioredoxin AB180_12090 ENOG4106IUH DTW domain containing protein AB180_12095 ENOG4105CD5 CoA-binding domain protein AB180_12100 ENOG4105JIM Phosphatidylserine synthase AB180_12105 ENOG4105T42 (LipO)protein AB180_12110 ENOG4105CSH Transporter AB180_12135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AB180_12140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AB180_12145 ENOG4105C34 Pseudouridine synthase AB180_12150 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AB180_12155 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AB180_12160 ENOG4105CQC Prephenate dehydratase AB180_12165 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AB180_12170 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AB180_12175 ENOG4105QP9 Protein of unknown function (DUF2799) AB180_12180 ENOG4108WS1 AB180_12185 ENOG4108KHX Diguanylate cyclase AB180_12190 ENOG41090EK ompa motb domain protein AB180_12195 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AB180_12205 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AB180_12210 ENOG4105K5M 30s ribosomal protein S16 AB180_12215 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AB180_12220 ENOG4106KVJ cytochrome C assembly protein AB180_12225 ENOG4108JU6 CBS domain protein AB180_12240 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AB180_12245 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AB180_12250 ENOG4105VDB UPF0125 protein AB180_12255 ENOG4108Z1B Cyclase dehydrase AB180_12275 ENOG4105BZ1 (ABC) transporter AB180_12285 ENOG4105DFP Integrase AB180_12350 ENOG4105TNG K13735 adhesin invasin AB180_12360 ENOG4105DH8 myo-inositol catabolism AB180_12370 ENOG4105D7K pfkb domain protein AB180_12380 ENOG4105CNN ABC, transporter AB180_12385 ENOG4105C2J ABC transporter AB180_12390 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AB180_12400 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AB180_12405 ENOG4105C26 Dehydrogenase AB180_12415 ENOG4105Y4Z Outer Membrane Lipoprotein AB180_12420 ENOG4105C1P efflux transporter, rnd family, mfp subunit AB180_12425 ENOG4105BZS acriflavin resistance protein AB180_12440 ENOG4108V08 YfdX protein AB180_12445 ENOG4105BZU Histidine kinase AB180_12450 ENOG4108WQH regulatoR AB180_12455 ENOG4105DJB Major Facilitator Superfamily AB180_12465 ENOG4107S4Y M20 DapE family protein YgeY AB180_12470 ENOG4107RCH Diaminopropionate ammonia-lyase AB180_12475 ENOG4108JUB Transcriptional regulator AB180_12485 ENOG4107B2H carbonic anhydrase AB180_12495 ENOG4105CMR udp-glucose 4-epimerase AB180_12510 ENOG4107RA4 Glycosyl transferase (Group 1 AB180_12515 ENOG41088YS Glycosyl transferase (Group 1 AB180_12560 ENOG4108NAE Fimbrial chaperone protein AB180_12565 ENOG4105CW0 outer membrane usher protein AB180_12575 ENOG4105DHQ Histidine kinase AB180_12620 ENOG4105EAA nucleoside AB180_12625 ENOG4105KT7 mgtC SapB transporter AB180_12635 ENOG4105D5U fad dependent oxidoreductase AB180_12640 ENOG4105C26 Dehydrogenase AB180_12645 ENOG4108JPW Aminotransferase AB180_12650 ENOG4105C85 amino acid AB180_12655 ENOG4108PVQ transcriptional regulator AB180_12660 ENOG4109066 lysm domain bon superfamily protein AB180_12665 ENOG4105VPI YqaE family transport protein AB180_12670 ENOG41080HT Transcriptional regulator, arsr family AB180_12675 ENOG4108V62 Rhodanese domain protein AB180_12685 ENOG4108X73 DNA- binding protein AB180_12690 ENOG4108RNS Exports L-alanine (By similarity) AB180_12695 ENOG4108WMJ Protein of unknown function (DUF2002) AB180_12705 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AB180_12710 ENOG4105WAZ (Glutaredoxin-like protein) NrdH AB180_12715 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AB180_12720 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AB180_12725 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AB180_12730 ENOG4108IJ7 Glycine betaine AB180_12735 ENOG4108HQS Glycine betaine AB180_12740 ENOG4105GIJ Glycine betaine AB180_12750 ENOG4108UMN azlc family AB180_12755 ENOG4105ZED uncharacterized protein ygaH AB180_12760 ENOG4105NTK Transcriptional repressor Mpra AB180_12765 ENOG4105CW7 secretion protein, HlyD family AB180_12770 ENOG4105C0R drug resistance transporter emrb qaca subfamily AB180_12790 ENOG4105W39 Membrane AB180_12795 ENOG4107VXZ Hydrolase AB180_12825 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AB180_12830 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AB180_12840 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) AB180_12845 ENOG4107TH8 cina domain protein AB180_12850 ENOG4105CVE Lytic murein transglycosylase AB180_12855 ENOG410787A Pts system, glucitol sorbitol-specific AB180_12860 ENOG4105DZY Pts system, glucitol sorbitol-specific AB180_12865 ENOG4105VI0 Pts system, glucitol sorbitol-specific AB180_12870 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase AB180_12875 ENOG4105J92 DNA-binding transcriptional activator GutM AB180_12880 ENOG410804X Transcriptional regulator AB180_12885 ENOG4105C2X Arabinose 5-phosphate isomerase AB180_12890 ENOG4108JUA Transcriptional regulator AB180_12895 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center AB180_12900 ENOG4107QZF nitrite reductase NADPH large subunit AB180_12905 ENOG4105C8H hydrogenase maturation protein Hypf AB180_12910 ENOG4108RC0 Electron transport protein AB180_12915 ENOG4105DDV Transcriptional regulator (LacI family AB180_12925 ENOG4105CS2 ec 3.2.1.21 AB180_12935 ENOG4108MG9 hydrogenase 3 maturation protease AB180_12940 ENOG4105I6X formate hydrogenlyase maturation AB180_12945 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit AB180_12950 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit AB180_12955 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AB180_12960 ENOG4107TDF Formate hydrogenlyase subunit 4 AB180_12965 ENOG4107R30 NADH dehydrogenase AB180_12970 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) AB180_12975 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA AB180_12980 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AB180_12985 ENOG4107RSS Hydrogenase accessory protein HypB AB180_12990 ENOG41083WG hydrogenase assembly chaperone AB180_12995 ENOG4105CQS hydrogenase expression formation protein HypD AB180_13000 ENOG4105C45 hydrogenase expression formation protein (HypE) AB180_13010 ENOG4105VXR cytoplasmic protein AB180_13020 ENOG4105DIK (ABC) transporter AB180_13025 ENOG4105CC5 ABC transporter AB180_13030 ENOG4105CC5 ABC transporter AB180_13045 ENOG4105C6N Formate acetyltransferase AB180_13050 ENOG4105F1A Pyruvate formate-lyase AB180_13065 ENOG4105ENT Efflux transporter rnd family, mfp subunit AB180_13070 ENOG4105BZS acriflavin resistance protein AB180_13075 ENOG4105DSF transport protein AB180_13085 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AB180_13090 ENOG4107635 Hok Gef family protein AB180_13095 ENOG4105KZM cytoplasmic protein AB180_13100 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AB180_13105 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AB180_13120 ENOG4108K5P (LipO)protein AB180_13125 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) AB180_13130 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) AB180_13135 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) AB180_13145 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AB180_13155 ENOG4105N0Z inner membrane protein ygbE AB180_13165 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) AB180_13175 ENOG4108MXK alkaline phosphatase isozyme conversion AB180_13180 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AB180_13195 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AB180_13200 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AB180_13205 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) AB180_13215 ENOG4105QEK Transcriptional regulator AB180_13225 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AB180_13230 ENOG4105DXN mazG family AB180_13235 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AB180_13240 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AB180_13245 ENOG4105BZU Histidine kinase AB180_13250 ENOG4105BZW Glycerate kinase AB180_13255 ENOG4105EQX glucarate dehydratase AB180_13260 ENOG4105EQX glucarate dehydratase AB180_13265 ENOG4105DJB Major Facilitator Superfamily AB180_13270 ENOG4105QDK Flavodoxin AB180_13275 ENOG4105DR9 pseudouridine synthase AB180_13280 ENOG4105WP7 tRNA pseudouridine synthase C AB180_13285 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) AB180_13290 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AB180_13295 ENOG4105EWT decarboxylase family AB180_13300 ENOG4105C44 Serine transporter AB180_13305 ENOG4105EJQ L-serine dehydratase AB180_13315 ENOG4105C0A alcohol dehydrogenase AB180_13320 ENOG4107W7X Aldolase AB180_13330 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AB180_13340 ENOG4105CNN ABC, transporter AB180_13345 ENOG4105C2J ABC transporter AB180_13350 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) AB180_13355 ENOG4105CMG Carbohydrate kinase AB180_13365 ENOG4107EDW L-fucose operon activator AB180_13370 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) AB180_13375 ENOG4105M08 Membrane AB180_13380 ENOG4105ETT transcriptional Regulator, LysR family AB180_13385 ENOG4105M5B (LipO)protein AB180_13390 ENOG4105C9B Cysteine desulfurase AB180_13395 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AB180_13400 ENOG4105CUZ uba thif-type nad fad binding protein AB180_13405 ENOG4105CA3 membrane-bound lytic murein transglycosylase AB180_13440 ENOG4105CW0 outer membrane usher protein AB180_13445 ENOG4108VEV chaperone AB180_13470 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AB180_13475 ENOG4107QZM n-acetylglutamate synthase AB180_13480 ENOG4107QYX exodeoxyribonuclease v alpha AB180_13485 ENOG4107QKA exodeoxyribonuclease V beta AB180_13490 ENOG4107QXK peptidase AB180_13495 ENOG4105DSY exodeoxyribonuclease V, gamma AB180_13500 ENOG4105RVB Prepilin peptidase dependent protein c AB180_13505 ENOG4105SEN Protein of unknown function (DUF2509) AB180_13510 ENOG4105JCS prepilin peptidase dependent protein AB180_13515 ENOG4105IPU prepilin peptidase dependent protein A AB180_13530 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AB180_13545 ENOG4105EE5 Membrane protein terC AB180_13550 ENOG4105SUV lipoprotein YgdR AB180_13555 ENOG4105CPC Aldo Keto reductase AB180_13560 ENOG4107S74 Lysophospholipid transporter LplT AB180_13580 ENOG4105DDV Transcriptional regulator (LacI family AB180_13585 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AB180_13590 ENOG4105RQF LysR family Transcriptional regulator AB180_13605 ENOG4105DNE Transposase AB180_13610 ENOG4107QNK )-transporter AB180_13615 ENOG4105CHR reductase AB180_13625 ENOG4105CHU acetyl-coa acetyltransferase AB180_13630 ENOG4105C5Q Transcriptional regulator AB180_13640 ENOG4108MHD transport protein AB180_13650 ENOG41061MD high-affinity nickel-transporter AB180_13655 ENOG4105DZC cytosine deaminase AB180_13660 ENOG4105C5B carbamate kinase AB180_13670 ENOG4107REC cytoplasmic protein AB180_13675 ENOG4107R1Q Membrane protein FdrA AB180_13680 ENOG4105N16 Protein of unknown function (DUF2877) AB180_13685 ENOG4107SNB ankyrin repeat protein YahD AB180_13690 ENOG4108NUU Transcriptional regulator AB180_13695 ENOG410830R acetyltransferase AB180_13700 ENOG4105VR1 Pfam:DUF1271 AB180_13710 ENOG4105CND Glycosyl transferase, family 2 AB180_13715 ENOG4107BJW polysaccharide deacetylase AB180_13720 ENOG4108TUY outer membrane protein PgaA AB180_13775 ENOG4105CMM transposase AB180_13830 ENOG4108K5P (LipO)protein AB180_13840 ENOG4105CRK lysyL-tRNA synthetase AB180_13850 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AB180_13855 ENOG4105T95 Thiol disulfide interChange protein AB180_13860 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AB180_13865 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AB180_13870 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB AB180_13875 ENOG4105Y75 tpr repeat protein AB180_13885 ENOG4108UT2 hemolysin iii AB180_13895 ENOG4108Q3X Transcriptional regulator AB180_13900 ENOG4105CS2 ec 3.2.1.21 AB180_13905 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AB180_13910 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AB180_13925 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AB180_13930 ENOG4105D0A hydroxylase AB180_13935 ENOG4107RAQ aminopeptidase AB180_13945 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) AB180_13950 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AB180_13955 ENOG4108JQ1 Dehydrogenase AB180_13965 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) AB180_13970 ENOG4105D5P Methylmalonyl-coA mutase AB180_13975 ENOG4105DJT lAO AO transport system ATPase AB180_13980 ENOG4108M7F enoyl-CoA hydratase isomerase AB180_13985 ENOG4105CYC Transferase AB180_13990 ENOG4105DEQ transcriptional regulator AB180_13995 ENOG4105MPN Membrane AB180_14000 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AB180_14005 ENOG4105D64 Mechanosensitive ion channel AB180_14010 ENOG4105D2N Aldolase AB180_14020 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AB180_14040 ENOG4108JJB ABC transporter AB180_14045 ENOG4108JJB ABC transporter AB180_14050 ENOG4105CV1 Transketolase (EC 2.2.1.1) AB180_14055 ENOG4108K0D peptidase, M48 AB180_14065 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AB180_14070 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AB180_14075 ENOG4107QNK )-transporter AB180_14085 ENOG4105RWS endonuclease I AB180_14090 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AB180_14095 ENOG4105D7Z glutathione synthase AB180_14100 ENOG4108UJU UPF0301 protein AB180_14105 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AB180_14110 ENOG4105CZX twitching motility protein AB180_14115 ENOG4105DFA alanine racemase domain protein AB180_14120 ENOG4108VIA integral membrane protein AB180_14125 ENOG4105VZ9 UPF0235 protein AB180_14130 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AB180_14135 ENOG4105CSA Coproporphyrinogen iii oxidase AB180_14140 ENOG4105HDK L-asparaginase AB180_14145 ENOG4105K33 Periplasmic Protein AB180_14150 ENOG41090ED Protein with unknown function (DUF469) AB180_14155 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AB180_14160 ENOG4105CEN a g-specific adenine glycosylase AB180_14165 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) AB180_14170 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division AB180_14175 ENOG4105EAA nucleoside AB180_14180 ENOG4105CXN decarboxylase AB180_14185 ENOG4108UQV Membrane AB180_14195 ENOG4106032 Glutathionylspermidine synthase AB180_14200 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AB180_14205 ENOG4105CYM Glutathione S-transferase AB180_14210 ENOG41082MF Hydrogenase assembly chaperone hypC hupF AB180_14215 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AB180_14220 ENOG4108WGS hydrogenase 2-specific chaperone AB180_14225 ENOG4108USZ hydrogenase AB180_14230 ENOG4105DPX Hydrogenase, large subunit AB180_14235 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit AB180_14240 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AB180_14245 ENOG4105E3S small subunit AB180_14250 ENOG410900S Protein of unknown function (DUF2623) AB180_14255 ENOG4105C8Q Methyl-accepting chemotaxis AB180_14265 ENOG4105CPC Aldo Keto reductase AB180_14285 ENOG4108ZZF transport protein (ExbD) AB180_14290 ENOG4105CWK Biopolymer transport protein, ExbB AB180_14295 ENOG4105C28 cystathionine AB180_14300 ENOG4108K81 inner membrane protein YghB AB180_14305 ENOG4105CF7 AraC family transcriptional regulator AB180_14310 ENOG4108I6A alcohol dehydrogenase AB180_14315 ENOG4105CV8 reductase AB180_14320 ENOG4107QPK )-transporter AB180_14330 ENOG4105CCT upf0313 protein AB180_14335 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AB180_14340 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) AB180_14345 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AB180_14350 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AB180_14355 ENOG4105H4F exported protein AB180_14360 ENOG4105XJC Two component transcriptional regulator (Winged helix family AB180_14365 ENOG4105DHQ Histidine kinase AB180_14370 ENOG4105NF4 modulator of drug activity AB180_14375 ENOG4105VRH Antibiotic biosynthesis monooxygenase AB180_14380 ENOG4105EP8 Glycosyl Hydrolase Family 88 AB180_14385 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AB180_14395 ENOG4105ID8 Transcriptional regulator, ARAC family AB180_14400 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AB180_14405 ENOG4105IPS esterase AB180_14410 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AB180_14415 ENOG4108SX3 cytoplasmic protein AB180_14420 ENOG41087AY ADP-Ribose pyrophosphatase AB180_14430 ENOG4105F1G UPF0441 protein AB180_14435 ENOG4106032 Glutathionylspermidine synthase AB180_14440 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AB180_14450 ENOG4108MR7 Arylsulfotransferase AB180_14470 ENOG4105W0Z cytoplasmic protein AB180_14480 ENOG4105PV3 Inner membrane protein yqiJ AB180_14485 ENOG4107S78 Band 7 protein AB180_14490 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) AB180_14495 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) AB180_14500 ENOG4105I7R Adenylate cyclase AB180_14505 ENOG4106MWK domain protein AB180_14510 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate AB180_14515 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AB180_14520 ENOG4107ZVW dihydroneopterin aldolase AB180_14530 ENOG4105EJC lysr family transcriptional regulator AB180_14535 ENOG4106DSS Tartrate dehydratase subunit alpha AB180_14540 ENOG4107GFK fumarate AB180_14545 ENOG4107QPK )-transporter AB180_14550 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AB180_14555 ENOG4108YZ9 Urea amidohydrolase subunit gamma AB180_14560 ENOG4105KI2 Urea amidohydrolase subunit beta AB180_14565 ENOG4105CQM Urea amidohydrolase subunit alpha AB180_14570 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) AB180_14575 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) AB180_14580 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) AB180_14585 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AB180_14590 ENOG4105VCC 30S ribosomal protein S21 AB180_14595 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AB180_14600 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AB180_14605 ENOG4108NS2 receptor AB180_14610 ENOG4105D05 Receptor AB180_14625 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures AB180_14635 ENOG4105ZS6 Protein of unknown function (DUF987) AB180_14640 ENOG4108XS9 dna repair protein AB180_14645 ENOG4105MFG Antirestriction protein AB180_14650 ENOG4106ZN7 UPF0401 protein YkfF AB180_14655 ENOG4106J9S Prophage AB180_14670 ENOG4108KZE transcriptional regulator AB180_14675 ENOG4106H6R UPF0380 protein AB180_14680 ENOG4108MXD gtp-binding protein AB180_14700 ENOG4105H5P transposase AB180_14705 ENOG4108P8R AB180_14720 ENOG4105MZU cell filamentation protein AB180_14730 ENOG4105V2F Uncharacterized protein yoac AB180_14735 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit AB180_14740 ENOG4108ZFT Dehydratase small subunit AB180_14745 ENOG4105YCI dehydratase medium subunit AB180_14790 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AB180_14800 ENOG4105Q26 Siderophore-interacting protein AB180_14805 ENOG4105NTW Transcriptional regulator AB180_14810 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AB180_14820 ENOG4108Y51 tRNA-binding protein AB180_14825 ENOG4105CQ4 Transcriptional regulator AB180_14830 ENOG4105CNT hydrolase family 2 AB180_14835 ENOG4105FK9 beta-D-galactosidase beta subunit AB180_14840 ENOG4105E5D amino acid AB180_14845 ENOG4107W6W Conserved Protein AB180_14850 ENOG4107WCA isomerase AB180_14855 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AB180_14860 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AB180_14865 ENOG4108VKG metal-dependent hydrolase AB180_14870 ENOG4105EE0 oxidoreductase AB180_14875 ENOG4105DU1 integral membrane protein, terc AB180_14885 ENOG4105P66 Membrane AB180_14890 ENOG4105CTX dehydratase AB180_14900 ENOG4105DPW Major facilitator superfamily MFS_1 AB180_14905 ENOG4107YCY Transcriptional regulator AB180_14910 ENOG4106W5V Membrane AB180_14920 ENOG4105WAY exported protein AB180_14925 ENOG4105NE1 Conserved Protein AB180_14930 ENOG41090KG Inner membrane protein YqjE AB180_14935 ENOG4105YJD AB180_14940 ENOG4108VBZ doxx family AB180_14945 ENOG4105CHF Glutathione S-transferase AB180_14950 ENOG4105KAF membrAne AB180_14955 ENOG4105CWB LysR family transcriptional Regulator AB180_14960 ENOG4108CNN domain protein AB180_14970 ENOG4105C44 Serine transporter AB180_14975 ENOG4105EJQ L-serine dehydratase AB180_14980 ENOG4105KME endoribonuclease L-psp AB180_14985 ENOG4105C6N Formate acetyltransferase AB180_14995 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) AB180_15000 ENOG4105C7B Threonine dehydratase AB180_15005 ENOG410811B TRANSCRIPTIONal AB180_15020 ENOG4108YXQ IS66 Orf2 family protein AB180_15025 ENOG4105E5H Transposase AB180_15045 ENOG4105CMM transposase AB180_15050 ENOG4105I03 Flagellin AB180_15070 ENOG4108ZQS transposase AB180_15075 ENOG4108MVM Transposase AB180_15080 ENOG4105BZW Glycerate kinase AB180_15085 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AB180_15090 ENOG4105CNV Aldolase AB180_15095 ENOG4105DJB Major Facilitator Superfamily AB180_15100 ENOG4105CTX dehydratase AB180_15110 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component AB180_15115 ENOG4105DRS transport system, permease AB180_15120 ENOG4108IJ9 (ABC) transporter AB180_15130 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) AB180_15135 ENOG4105E98 transcriptional regulator DeoR family AB180_15140 ENOG4105E98 transcriptional regulator DeoR family AB180_15145 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of AB180_15150 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB AB180_15160 ENOG4105F3R pts system mannose fructose sorbose family iid AB180_15165 ENOG4108YTN IIa component AB180_15170 ENOG4105CE4 GlcNAc 6-P deacetylase AB180_15175 ENOG4105E70 isomerase AB180_15180 ENOG4105D2N Aldolase AB180_15185 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AB180_15200 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AB180_15205 ENOG4105W4M Transport-associated protein AB180_15210 ENOG4105K4T epimerase AB180_15215 ENOG4108ZPB UPF0306 protein AB180_15220 ENOG41082IR Excinuclease ABC C subunit domain protein AB180_15225 ENOG4108YYD acetyltransferase AB180_15230 ENOG4105XPQ lipid carrier protein AB180_15235 ENOG4105CFP Peptidase U32 AB180_15240 ENOG4106RZ4 Peptidase U32 AB180_15245 ENOG4105DEN Luciferase family AB180_15250 ENOG4105CIC tryptophan-specific transport protein AB180_15255 ENOG4105C1J atp-dependent rna helicase AB180_15260 ENOG4105RT1 May be involved in cell division (By similarity) AB180_15280 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AB180_15285 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AB180_15290 ENOG4105CHV Transcription elongation factor NusA AB180_15295 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AB180_15305 ENOG4105CDH Citrulline--aspartate ligase AB180_15320 ENOG4107YNJ LysR family Transcriptional regulator AB180_15325 ENOG4105DYB Isoaspartyl dipeptidase AB180_15330 ENOG4105CEE C4-dicarboxylate transporter AB180_15335 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AB180_15340 ENOG4105EEI dihydropteroate synthase AB180_15345 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AB180_15355 ENOG4105HBR Rna-binding protein AB180_15360 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AB180_15365 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AB180_15370 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AB180_15375 ENOG4105QYV Membrane AB180_15380 ENOG4105K46 50S ribosomal protein l27 AB180_15390 ENOG4105EAH synthase AB180_15395 ENOG4105HVQ Regulatory factor of maltose metabolism AB180_15405 ENOG4105VFK BolA family AB180_15410 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane AB180_15415 ENOG4105E3I toluene tolerance AB180_15420 ENOG4107PE3 Mammalian cell entry related domain protein AB180_15425 ENOG4105CY3 ABC transporter, permease AB180_15430 ENOG4105DHJ ABC, transporter AB180_15435 ENOG4105FEU K -dependent Na -Ca exchanger AB180_15440 ENOG4105C2X Arabinose 5-phosphate isomerase AB180_15445 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AB180_15450 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) AB180_15455 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AB180_15460 ENOG4108IUZ ABC transporter AB180_15465 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AB180_15470 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AB180_15475 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AB180_15480 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AB180_15485 ENOG41080Z8 PHOSPHOCARRIER protein AB180_15490 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase AB180_15495 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AB180_15500 ENOG4105BZU Histidine kinase AB180_15505 ENOG4105N5T Radical SAM Protein AB180_15515 ENOG4105CBC glutamate synthase AB180_15520 ENOG4105BZ8 glutamate synthase AB180_15525 ENOG4105DFS Conserved Protein AB180_15530 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin AB180_15535 ENOG4105DZC cytosine deaminase AB180_15540 ENOG4108R66 Conserved Protein AB180_15545 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) AB180_15550 ENOG4105JHE Major Facilitator Superfamily AB180_15555 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AB180_15565 ENOG4105CEE C4-dicarboxylate transporter AB180_15570 ENOG4105KB2 stringent starvation protein b AB180_15575 ENOG4107MKT Stringent starvation protein a AB180_15585 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AB180_15590 ENOG4105D6Z AFG1 family ATPase AB180_15595 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AB180_15600 ENOG4105C0H protease AB180_15605 ENOG4105C0H protease AB180_15615 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AB180_15625 ENOG4105UNR (Barnase) inhibitor AB180_15630 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) AB180_15635 ENOG4105Y49 secretion protein, HlyD family AB180_15645 ENOG4105CR8 Transcriptional regulator AB180_15650 ENOG4105D1U peptidase U62 modulator of DNA gyrase AB180_15655 ENOG4105QD6 exported protein AB180_15660 ENOG4105C03 ribonuclease AB180_15670 ENOG4105VQ7 Rod shape-determining protein MreD AB180_15675 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AB180_15680 ENOG4105DFF Rod shape-determining protein mreb AB180_15685 ENOG41062P1 Diguanylate cyclase phosphodiesterase AB180_15690 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AB180_15700 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) AB180_15705 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AB180_15710 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AB180_15715 ENOG4105RG0 Membrane AB180_15720 ENOG4108IA2 Sodium pantothenate symporter AB180_15735 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AB180_15740 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AB180_15815 ENOG4105CMM transposase AB180_15830 ENOG4105CEC DNA methylase N-4 N-6 AB180_15835 ENOG41061ME transport protein AB180_15840 ENOG4108XG4 DNA-binding transcriptional regulator AB180_15845 ENOG4105C1P efflux transporter, rnd family, mfp subunit AB180_15850 ENOG4105BZS acriflavin resistance protein AB180_15855 ENOG4105XCM membrane LIPOPROTEIN AB180_15865 ENOG4105EZ7 amino acid ABC transporter AB180_15870 ENOG4105DRP amino acid AbC transporter AB180_15875 ENOG4105CDA abc transporter atp-binding protein AB180_15915 ENOG4108Z0R Transferase AB180_15920 ENOG4105SG3 Protein of unknown function (DUF1488) AB180_15925 ENOG4105E2X shikimate dehydrogenase AB180_15930 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AB180_15935 ENOG4108WI1 Dna topoisomerase AB180_15945 ENOG4105C79 DNA protecting protein DprA AB180_15950 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AB180_15965 ENOG4105C1A potassium transporter peripheral membrane AB180_15975 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system AB180_15980 ENOG4105W1Y Transcriptional regulator AB180_15985 ENOG4105VTS DnaJ-like, subfamily C AB180_15995 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AB180_16000 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AB180_16005 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AB180_16015 ENOG41067V7 50S ribosomal protein L36 AB180_16020 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AB180_16025 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AB180_16030 ENOG4105VPB 50S ribosomal protein L30 AB180_16035 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AB180_16040 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AB180_16045 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AB180_16050 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AB180_16055 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AB180_16070 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AB180_16075 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AB180_16080 ENOG41083MP 50s ribosomal protein l29 AB180_16090 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AB180_16095 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AB180_16100 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AB180_16115 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AB180_16120 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AB180_16130 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AB180_16135 ENOG4108UQY Iron-storage protein AB180_16140 ENOG4105W53 bacterioferritin-associated ferredoxin AB180_16150 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AB180_16155 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AB180_16170 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) AB180_16175 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) AB180_16180 ENOG4105WWK YheO domain protein AB180_16185 ENOG4108V1T peptidylprolyl cis-trans isomerase AB180_16190 ENOG4105VRX Protein slyX homolog AB180_16195 ENOG4108YZY peptidylprolyl cis-trans isomerase AB180_16200 ENOG4105VKU nucleicacid-binding protein AB180_16205 ENOG4105CKD glutathione-regulated potassium-efflux system protein AB180_16210 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AB180_16215 ENOG4105C5H ABC transporter AB180_16225 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AB180_16235 ENOG4105DNZ Alpha Beta Hydrolase AB180_16245 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AB180_16250 ENOG4108UKZ OsmC family AB180_16260 ENOG410613R integral membrane protein, YccS YhfK family AB180_16265 ENOG4105C8Y Acetylornithine aminotransferase AB180_16270 ENOG4105DDQ anthranilate synthase AB180_16275 ENOG4105MZU cell filamentation protein AB180_16280 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AB180_16290 ENOG4107QZF nitrite reductase NADPH large subunit AB180_16295 ENOG4105WZK nitrite reductase NADPH small subunit AB180_16300 ENOG4107V9H nitrite transporter AB180_16310 ENOG4105VYH AB180_16315 ENOG4106PKC pyridoxal phosphate binding AB180_16320 ENOG4106M0N transport system permease protein AB180_16325 ENOG4105MUZ Protein of unknown function DUF2620 AB180_16330 ENOG41080QX K07048 phosphotriesterase-related protein AB180_16335 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AB180_16340 ENOG4108626 Racemase AB180_16345 ENOG4105RMW regulation of transcription, DNA-dependent AB180_16350 ENOG4108M21 AB180_16355 ENOG4105C31 Tryptophanyl-tRNA synthetase AB180_16360 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AB180_16365 ENOG4105DJV ribulose-phosphate 3-epimerase AB180_16370 ENOG4105DFE Dna adenine methylase AB180_16375 ENOG4105EGB membrane protein DamX AB180_16380 ENOG4105D49 3-dehydroquinate synthase AB180_16385 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AB180_16390 ENOG4105E4G Type IV pilus AB180_16395 ENOG4105ITY Required for the use of extracellular DNA as a nutrient AB180_16400 ENOG4105XPX DNA utilization protein HofO AB180_16405 ENOG41065NF Fimbrial assembly family protein AB180_16410 ENOG4108U1Q Pilus assembly protein AB180_16415 ENOG4108JQC penicillin-binding protein 1A AB180_16420 ENOG4107RK2 ADP-ribose diphosphatase NudE AB180_16425 ENOG4105DQY intracellular growth attenuator AB180_16430 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AB180_16435 ENOG4105VEJ Heat shock protein AB180_16445 ENOG4108MAJ Membrane AB180_16450 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AB180_16465 ENOG4105E0F Histidine kinase AB180_16470 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AB180_16475 ENOG4108RRZ Transcription elongation factor GreB AB180_16480 ENOG4105BZM domain protein AB180_16485 ENOG4105XFK Ferrous iron transport protein A AB180_16490 ENOG4105CE1 Ferrous iron transport protein b AB180_16510 ENOG4105MJ2 Competence protein AB180_16515 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) AB180_16520 ENOG4105C6Z Gluconate AB180_16525 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AB180_16530 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AB180_16535 ENOG41061ZR Transcriptional regulator AB180_16540 ENOG4105E98 transcriptional regulator DeoR family AB180_16545 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) AB180_16550 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) AB180_16555 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AB180_16560 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AB180_16565 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AB180_16575 ENOG4108IUM Glycogen debranching enzyme AB180_16580 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) AB180_16585 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AB180_16590 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AB180_16600 ENOG4105C6Z Gluconate AB180_16605 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AB180_16610 ENOG4105DIQ Transcriptional regulator AB180_16615 ENOG4105C2I pirin domain protein AB180_16620 ENOG4105D9R oxidoreductase AB180_16625 ENOG4105WCN acetyltransferase AB180_16635 ENOG4108RVA ribokinase AB180_16650 ENOG41080QX K07048 phosphotriesterase-related protein AB180_16655 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AB180_16660 ENOG4105WC8 Conserved Protein AB180_16665 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AB180_16670 ENOG4108IJ9 (ABC) transporter AB180_16680 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AB180_16685 ENOG4105BZ7 extracellular solute-binding protein family 1 AB180_16695 ENOG4108IV0 ABC, transporter AB180_16700 ENOG4105C0Z ABC transporter AB180_16705 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AB180_16710 ENOG4105C32 Amino acid ABC transporter (Permease) AB180_16715 ENOG4105CP9 extracellular ligand-binding receptor AB180_16720 ENOG4105U59 -acetyltransferase AB180_16735 ENOG4105CRP Part of the ABC transporter FtsEX involved in AB180_16740 ENOG4105CAK Cell division ATP-binding protein ftsE AB180_16745 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AB180_16750 ENOG4106H78 methyltransferase AB180_16755 ENOG4105MG3 Membrane AB180_16780 ENOG4107FS9 Membrane AB180_16790 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) AB180_16795 ENOG4105EX9 Membrane AB180_16800 ENOG4108W1V Lipoprotein AB180_16805 ENOG4105F9N Major Facilitator Superfamily AB180_16810 ENOG4105DSF transport protein AB180_16815 ENOG4107YAK holo-(acyl carrier protein) synthase 2 AB180_16820 ENOG4105MRR Transcriptional regulator (By similarity) AB180_16835 ENOG4105CMI transporter AB180_16840 ENOG4105CJ1 ABC, transporter AB180_16845 ENOG4105D0S secretion protein (HlyD AB180_16850 ENOG4105CJW magnesium transporter AB180_16855 ENOG4105E5H Transposase AB180_16860 ENOG4108YXQ IS66 Orf2 family protein AB180_16875 ENOG4105GR3 Histidine kinase AB180_16880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AB180_16885 ENOG4108PG2 copper resistance AB180_16890 ENOG4105JDN Copper resistance protein AB180_16895 ENOG4105VR0 copper resistance AB180_16900 ENOG4105E3B Multicopper oxidase AB180_16910 ENOG4105DR5 peptidase AB180_16940 ENOG410624V efflux system protein AB180_16995 ENOG4105CBX hi0933 family AB180_17000 ENOG4105CJ3 phosphate transporter AB180_17005 ENOG4108V6B universal stress protein B AB180_17010 ENOG4108M6U Universal stress protein A AB180_17015 ENOG4105DUX Transporter AB180_17020 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family AB180_17030 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AB180_17035 ENOG4105DGW oligopeptidase A AB180_17040 ENOG4105D6S protein involved in catabolism of external DNA AB180_17045 ENOG4105DC8 reductase AB180_17050 ENOG4105CA0 peroxidase AB180_17075 ENOG4106S2D Transcriptional regulator AB180_17080 ENOG4105BZU Histidine kinase AB180_17090 ENOG4105CHR reductase AB180_17095 ENOG4105CBN LysR family transcriptional regulator AB180_17100 ENOG4107H3J ribonuclease AB180_17105 ENOG4105CSH Transporter AB180_17110 ENOG41066T0 asmA family AB180_17115 ENOG4105CMB EAL domain-containing protein AB180_17120 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AB180_17125 ENOG4105CS0 peptidase AB180_17130 ENOG4105CK2 sodium dicarboxylate symporter AB180_17135 ENOG4105BZU Histidine kinase AB180_17145 ENOG4105C28 cystathionine AB180_17150 ENOG4105C44 Serine transporter AB180_17155 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AB180_17160 ENOG4108JQ7 (ABC) transporter AB180_17165 ENOG4105C3U ABC transporter AB180_17170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AB180_17175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AB180_17180 ENOG4105DEF Extracellular solute-binding protein, family 5 AB180_17195 ENOG4105DIJ Phosphoethanolamine transferase AB180_17200 ENOG4105FCD Major Facilitator AB180_17205 ENOG4105EAX Putative lipase AB180_17210 ENOG4108R3E Dna-3-methyladenine glycosylase i AB180_17215 ENOG4105HNP -acetyltransferase AB180_17220 ENOG4107QY8 reductase AB180_17225 ENOG4108ZG0 Ompa motb domain protein AB180_17230 ENOG4108M60 Transcriptional regulator AB180_17240 ENOG4105D7K pfkb domain protein AB180_17245 ENOG4105JHE Major Facilitator Superfamily AB180_17250 ENOG4105C5I Dehydrogenase AB180_17255 ENOG4106JH6 (LipO)protein AB180_17260 ENOG4105MVF Transcriptional regulator AB180_17265 ENOG4105VEQ Cold shock protein AB180_17275 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AB180_17290 ENOG4105MEV Acyl-transferase AB180_17295 ENOG410688U Inner membrane protein yiaB AB180_17300 ENOG4105CMG Carbohydrate kinase AB180_17310 ENOG4105T16 Transcriptional regulator (AraC family) AB180_17315 ENOG4108UR8 BAX protein AB180_17320 ENOG4107T9C Alpha amylase catalytic region AB180_17325 ENOG4105JKW Valine--pyruvate aminotransferase AB180_17330 ENOG4108XIB electron transport protein ysaA AB180_17335 ENOG4105J4Q Transcriptional regulator AB180_17340 ENOG4105DG4 malate L-lactate dehydrogenase AB180_17345 ENOG4108R66 Conserved Protein AB180_17355 ENOG4105DJB Major Facilitator Superfamily AB180_17360 ENOG4105CMG Carbohydrate kinase AB180_17365 ENOG4105H6Q decarboxylase AB180_17370 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase AB180_17375 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AB180_17380 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) AB180_17385 ENOG4105CT4 transporter AB180_17395 ENOG4105GNX MltA-interacting MipA family protein AB180_17400 ENOG4108Q2M Transcriptional regulator AB180_17405 ENOG4105EFX secretion protein, HlyD family AB180_17410 ENOG4105KK7 inner membrane protein YiaW AB180_17415 ENOG4105C26 Dehydrogenase AB180_17420 ENOG4105C0A alcohol dehydrogenase AB180_17425 ENOG4105EM7 Selenocysteine-specific translation elongation factor AB180_17435 ENOG4108U78 Glutathione S-transferase AB180_17440 ENOG4105EFX secretion protein, HlyD family AB180_17445 ENOG4105FP6 Protein of unknown function (DUF3302) AB180_17450 ENOG4105CTS PTS system mannitol-specific AB180_17460 ENOG4105E61 Mannitol repressor protein AB180_17470 ENOG4108YYI Protein of unknown function (DUF2810) AB180_17475 ENOG4105DAA L-lactate AB180_17480 ENOG41073TP transcriptional regulator AB180_17485 ENOG4105DMF Dehydrogenase AB180_17490 ENOG4105D2S major facilitator superfamily AB180_17495 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AB180_17500 ENOG4105D7W serine acetyltransferase AB180_17505 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AB180_17510 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) AB180_17515 ENOG4105VW4 glutaredoxin 3 AB180_17520 ENOG4107YZP Rhodanese domain protein AB180_17530 ENOG41063SB peptidase AB180_17535 ENOG4105PXI polysaccharide deacetylase AB180_17540 ENOG4105K64 Glycosyl transferase, family 2 AB180_17550 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AB180_17560 ENOG4105XA0 heptosyltransferase ii AB180_17565 ENOG4105D16 lipopolysaccharide heptosyltransferase i AB180_17570 ENOG41068PG O-Antigen polymerase AB180_17580 ENOG4105DKP glycosyl transferase, family 9 AB180_17585 ENOG4105X1N Glycosyl transferase family 8 AB180_17590 ENOG4105X1N Glycosyl transferase family 8 AB180_17595 ENOG4105X1N Glycosyl transferase family 8 AB180_17600 ENOG4107543 (lipo)polysaccharide AB180_17605 ENOG4107RJ7 Glycosyl transferase (Group 1 AB180_17615 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AB180_17620 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AB180_17625 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AB180_17630 ENOG4105W0E 50S ribosomal protein L33 AB180_17640 ENOG4105W5Q DNA repair protein (RadC AB180_17645 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AB180_17650 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AB180_17655 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) AB180_17670 ENOG4105DSJ YicC domain protein AB180_17675 ENOG4105EN6 Membrane AB180_17680 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) AB180_17690 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AB180_17695 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AB180_17700 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AB180_17705 ENOG4105CB5 ATP-dependent DNA helicase recG AB180_17710 ENOG4105D6U Sodium Glutamate Symporter AB180_17715 ENOG4105C2W permease AB180_17720 ENOG4105JV1 AsmA family AB180_17730 ENOG4105D2N Aldolase AB180_17735 ENOG4105D2N Aldolase AB180_17740 ENOG4105DM4 PTS System AB180_17745 ENOG4108YRF PTS System AB180_17750 ENOG4105DM4 PTS System AB180_17755 ENOG4105ETD TRANSCRIPTIONal AB180_17760 ENOG4105CJQ hydrolase, family 31 AB180_17765 ENOG4105CT4 transporter AB180_17805 ENOG4105ISV protein with bipartite regulator domain AB180_17825 ENOG4105EJC lysr family transcriptional regulator AB180_17830 ENOG4105CIS alcohol dehydrogenase AB180_17840 ENOG4108UZ3 Transporter AB180_17845 ENOG4105D01 (LipO)protein AB180_17850 ENOG4105DNE Transposase AB180_17865 ENOG4105F3R pts system mannose fructose sorbose family iid AB180_17870 ENOG4105ETZ PTS System AB180_17875 ENOG4108EQA pts system AB180_17900 ENOG4105CS2 ec 3.2.1.21 AB180_17910 ENOG4105KDP XRE family AB180_17920 ENOG4108SAJ Protein of unknown function (DUF1198) AB180_17925 ENOG4105CXY transporter AB180_17930 ENOG4105CXY transporter AB180_17935 ENOG4105BZU Histidine kinase AB180_17940 ENOG4108KX4 response regulator AB180_17950 ENOG4105EDR glucose galactose transporter AB180_17955 ENOG4108RVA ribokinase AB180_17960 ENOG4107FB0 transcriptional regulator DeoR family AB180_17965 ENOG4105M71 acetolactate synthase 1 regulatory subunit AB180_17970 ENOG4105C7K acetolactate synthase AB180_17985 ENOG4105E5M Multidrug resistance protein D AB180_17995 ENOG4105W8I Transcriptional regulator AB180_18005 ENOG4105BZC d-serine deaminase AB180_18010 ENOG4105J13 transcriptional regulator AB180_18015 ENOG4105JP4 Inner membrane protein yidG AB180_18020 ENOG4105VG5 Membrane AB180_18030 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) AB180_18035 ENOG4108ZNX Heat shock protein AB180_18040 ENOG4105R2A (LipO)protein AB180_18045 ENOG4105D99 atp gtp-binding protein AB180_18050 ENOG4107WAP fad NAD(P)-binding domain AB180_18055 ENOG410667J hydrolase AB180_18060 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AB180_18065 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AB180_18070 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AB180_18080 ENOG4105VG0 50S ribosomal protein l34 AB180_18085 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) AB180_18095 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AB180_18100 ENOG4105CNH Multidrug resistance protein MdtL AB180_18105 ENOG4105G2Y Transcriptional regulator AB180_18110 ENOG4105E8Q phosphopantetheinyl transferase AB180_18115 ENOG4108YYH Nadph-dependent fmn reductase AB180_18120 ENOG4105C7N Xanthine uracil vitamin C permease AB180_18125 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AB180_18140 ENOG4105E2Z phosphate ABC transporter (Permease AB180_18145 ENOG4105C8U phosphate abc transporter AB180_18150 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AB180_18160 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AB180_18165 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AB180_18170 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AB180_18175 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AB180_18180 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AB180_18185 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AB180_18190 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AB180_18195 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AB180_18200 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) AB180_18205 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation AB180_18210 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AB180_18220 ENOG4105QTB Flavodoxin AB180_18225 ENOG4108VVK transcriptional Regulator, AsnC AB180_18230 ENOG4105CU9 asparagine synthetase A AB180_18235 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AB180_18250 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AB180_18260 ENOG4105CNN ABC, transporter AB180_18265 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AB180_18270 ENOG4108RVA ribokinase AB180_18275 ENOG4105ETE Transcriptional regulator (LacI family AB180_18280 ENOG4105C0R drug resistance transporter emrb qaca subfamily AB180_18285 ENOG4107EJG GntR family transcriptional regulator AB180_18325 ENOG4108WFC UPF0438 protein yifE AB180_18330 ENOG4105C0P Mg chelatase subunit ChlI AB180_18340 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AB180_18345 ENOG4105CM2 brancheD-chain amino acid aminotransferase AB180_18355 ENOG4105C7B Threonine dehydratase AB180_18360 ENOG4105RKW reductase (By AB180_18365 ENOG4105EMY transcriptional regulator AB180_18375 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AB180_18380 ENOG4105C4R Atp-dependent dna helicase AB180_18385 ENOG4105C9X ppx gppa phosphatase AB180_18395 ENOG4105K63 Thioredoxin AB180_18405 ENOG4105ESV Glycosyl transferase, family 4 AB180_18410 ENOG4105SFE lipopolysaccharide biosynthesis protein AB180_18415 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AB180_18420 ENOG4108IJ1 Dehydrogenase AB180_18425 ENOG4108WJ1 acetyltransferase AB180_18430 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AB180_18435 ENOG4105EGZ biosynthesis protein AB180_18440 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) AB180_18450 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family AB180_18455 ENOG4105C85 amino acid AB180_18485 ENOG410601J HemY protein AB180_18490 ENOG4105ECF c-methyltransferase AB180_18495 ENOG41076E6 Uroporphyrinogen-III Synthase AB180_18505 ENOG4107T0K Adenylate cyclase AB180_18515 ENOG4105S7Z (LipO)protein AB180_18525 ENOG4105CT0 Protein of unknown function, DUF484 AB180_18530 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AB180_18535 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AB180_18540 ENOG4105C4R Atp-dependent dna helicase AB180_18550 ENOG4105FR1 rard protein AB180_18555 ENOG4108VUY thioesterase Superfamily protein AB180_18560 ENOG4105HDD phospholipase AB180_18565 ENOG4105C9U ATP-dependent DNA helicase RecQ AB180_18580 ENOG410829K Lysine exporter protein (Lyse ygga) AB180_18585 ENOG4108EUD Lysophospholipase AB180_18590 ENOG4105DQF Hydrolase AB180_18595 ENOG4105EMK carboxylate amino acid amine transporter AB180_18600 ENOG4105DZ2 Transcriptional regulator AB180_18610 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AB180_18615 ENOG4108I5U Uridine phosphorylase AB180_18620 ENOG4105CGY Dna recombination protein AB180_18630 ENOG4105JC1 sterol-binding domain protein AB180_18640 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AB180_18650 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AB180_18655 ENOG4105F8V Hydrolase, tatD family AB180_18660 ENOG4105MDZ Transcriptional activator rfaH AB180_18665 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AB180_18670 ENOG4107QK7 reductase AB180_18675 ENOG4105DKQ ROK family AB180_18680 ENOG4105ETE Transcriptional regulator (LacI family AB180_18690 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AB180_18700 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AB180_18705 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AB180_18710 ENOG4108RR8 protoporphyrinogen oxidase AB180_18740 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AB180_18745 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AB180_18750 ENOG4105PC1 Conserved Protein AB180_18765 ENOG4106HNH Acyl-transferase AB180_18770 ENOG4105C2M dna polymerase I AB180_18785 ENOG4105D4P Coproporphyrinogen iii oxidase AB180_18790 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AB180_18795 ENOG4105CUX Signal transduction histidine kinase AB180_18800 ENOG4105C5F glutamine synthetase AB180_18810 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is AB180_18815 ENOG4105CT4 transporter AB180_18820 ENOG4105CT4 transporter AB180_18825 ENOG4105CJQ hydrolase, family 31 AB180_18830 ENOG4107WI4 Aldose-1-epimerase AB180_18835 ENOG4107QKS N-acylglucosamine 2-epimerase AB180_18840 ENOG4105D2M Aldolase AB180_18845 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AB180_18850 ENOG4108MGF sugar kinase AB180_18855 ENOG4105E98 transcriptional regulator DeoR family AB180_18860 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 AB180_18865 ENOG4107S2Z UPF0761 membrane protein AB180_18870 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) AB180_18875 ENOG4105SUU thioesterase domain AB180_18890 ENOG41068KX affects formate dehydrogenase-N AB180_18900 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) AB180_18905 ENOG4108MG3 formate dehydrogenase AB180_18910 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AB180_18915 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_18920 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_18945 ENOG4106C3V frv operon regulatory protein AB180_18950 ENOG4105CN9 Peptidase m42 family protein AB180_18955 ENOG4105DM4 PTS System AB180_18960 ENOG41064BA PTS system, fructose-specific, IIA component AB180_18970 ENOG4108UMN azlc family AB180_18985 ENOG4105C0A alcohol dehydrogenase AB180_18995 ENOG4105DKG l-rhamnose isomerase AB180_19005 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) AB180_19010 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) AB180_19015 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) AB180_19020 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AB180_19030 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AB180_19035 ENOG4108RPX mosc domain containing protein AB180_19040 ENOG4105E0F Histidine kinase AB180_19045 ENOG4105E3W Two component transcriptional regulator (Winged helix family AB180_19050 ENOG4105FMW periplasmic AB180_19055 ENOG41076HS cation diffusion facilitator family transporter AB180_19060 ENOG4105CTQ phosphohexokinase AB180_19065 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AB180_19070 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) AB180_19080 ENOG4107QPK )-transporter AB180_19090 ENOG4105EBK exported protein AB180_19095 ENOG4108VTS Membrane AB180_19100 ENOG4105DP0 ferredoxin-NADP reductase AB180_19105 ENOG4105CBT Fructose-1,6-bisphosphatase AB180_19110 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AB180_19115 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AB180_19120 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) AB180_19125 ENOG4105CHR reductase AB180_19135 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AB180_19140 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AB180_19150 ENOG41063M6 Cell Division Protein AB180_19155 ENOG4105ETE Transcriptional regulator (LacI family AB180_19160 ENOG4105C25 Primosomal protein n' AB180_19165 ENOG4105VFB Binds the 23S rRNA (By similarity) AB180_19170 ENOG4108QGT oligogalacturonate-specific porin AB180_19175 ENOG4105CT4 transporter AB180_19180 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) AB180_19185 ENOG4105C28 cystathionine AB180_19190 ENOG4105CFH Aspartokinase AB180_19200 ENOG4105CGH 5'-nucleotidase AB180_19205 ENOG4108Z8I decarboxylase AB180_19210 ENOG4105CN8 Transcriptional regulator AB180_19215 ENOG4105SYT Methylenetetrahydrofolate reductase AB180_19220 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AB180_19225 ENOG4105DCT glycerol dehydrogenase AB180_19235 ENOG4106R3P AraC family transcriptional regulator AB180_19240 ENOG4105DIJ Phosphoethanolamine transferase AB180_19245 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) AB180_19260 ENOG4105CAS nag kinase AB180_19265 ENOG4105CH7 arginosuccinase AB180_19270 ENOG4105C5Q Transcriptional regulator AB180_19280 ENOG4105EJ2 Transcriptional regulator AB180_19285 ENOG4108Y73 Membrane AB180_19330 ENOG4105D4A Cell wall formation (By similarity) AB180_19335 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AB180_19370 ENOG4105PM1 preprotein translocase subunit SecE AB180_19375 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AB180_19380 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AB180_19385 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) AB180_19400 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AB180_19405 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AB180_19410 ENOG4105VCP PTS System AB180_19420 ENOG4105VEQ Cold shock protein AB180_19425 ENOG4105D41 biosynthesis protein thiH AB180_19435 ENOG4105WHD thiamine biosynthesis protein ThiS AB180_19440 ENOG4105D06 uba thif-type nad fad binding protein AB180_19455 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) AB180_19465 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AB180_19475 ENOG4105R2J Conserved Protein AB180_19480 ENOG4105K70 DNA-binding protein AB180_19485 ENOG4108T8B Protein of unknown function (DUF1481) AB180_19500 ENOG4105BZU Histidine kinase AB180_19505 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AB180_19510 ENOG4105C12 Phosphoribosylglycinamide synthetase AB180_19515 ENOG4105DC1 bifunctional purine biosynthesis protein purh AB180_19540 ENOG4105K5X acetyltransferase AB180_19545 ENOG4105CVG Homoserine O-transsuccinylase AB180_19550 ENOG4107QP3 malate synthase g AB180_19555 ENOG4108I9X Isocitrate lyase AB180_19560 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) AB180_19565 ENOG41069M3 Transcriptional regulator AB180_19570 ENOG4105C3R Methionine synthase AB180_19575 ENOG4105EAM Na Pi-cotransporter AB180_19595 ENOG4105YES addiction module antidote protein AB180_19610 ENOG4105F9E Shikimate 5-dehydrogenase AB180_19615 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein AB180_19620 ENOG4105F3R pts system mannose fructose sorbose family iid AB180_19625 ENOG4105ETZ PTS System AB180_19630 ENOG4105KPI PTS system sorbose subfamily IIB component AB180_19635 ENOG4108XCU pts system AB180_19640 ENOG4105CHR reductase AB180_19645 ENOG4105DKT Transcriptional regulator AB180_19650 ENOG4105FE9 pseudouridine synthase AB180_19655 ENOG4108ZR5 Conserved Protein AB180_19665 ENOG410667J hydrolase AB180_19680 ENOG4105C09 Bile acid AB180_19685 ENOG4105CYB regulatoR AB180_19695 ENOG410756H nucleotidyltransferase AB180_19700 ENOG4105CFH Aspartokinase AB180_19715 ENOG4108MDC (LipO)protein AB180_19720 ENOG4108Q9C Periplasmic Protein AB180_19725 ENOG4105E3R (LipO)protein AB180_19730 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AB180_19740 ENOG4105DFD Na H antiporter AB180_19745 ENOG4105C87 Aminotransferase class I and II AB180_19750 ENOG4105EG2 ABC transporter, permease AB180_19755 ENOG4105D56 permease protein AB180_19760 ENOG4107FKK extracellular solute-binding protein family 1 AB180_19775 ENOG4107W52 maltose operon periplasmic protein AB180_19780 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) AB180_19785 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) AB180_19790 ENOG4105E55 glycerol-3-phosphate acyltransferase AB180_19795 ENOG41080IJ Diacylglycerol kinase AB180_19805 ENOG4107R73 Mate efflux family protein AB180_19810 ENOG4105VDW Csbd family AB180_19815 ENOG4105MYN Zinc uptake regulation protein AB180_19825 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AB180_19830 ENOG4105P4Z Phage shock protein G AB180_19835 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AB180_19840 ENOG4105CDU Replicative dna helicase AB180_19850 ENOG4105CGF Aromatic amino acid aminotransferase AB180_19855 ENOG4105F0S class B acid phosphatase AB180_19860 ENOG4105MSB protein, conserved in bacteria AB180_19865 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AB180_19870 ENOG4108UUM single-stranded DNA-binding protein AB180_19875 ENOG4105PMV Membrane AB180_19880 ENOG4108M8H domain protein AB180_19885 ENOG4108W3Q Transcriptional regulator AB180_19890 ENOG4108Z4X TRANSCRIPTIONal AB180_19895 ENOG4105C7N Xanthine uracil vitamin C permease AB180_19900 ENOG4105EEQ Na H antiporter AB180_19905 ENOG4108UK5 Transposase AB180_19910 ENOG4105CMU LysR family (Transcriptional regulator AB180_19920 ENOG41067MG lrgb family AB180_19925 ENOG4107QN1 sodium solute AB180_19930 ENOG41062QD Membrane AB180_19935 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AB180_19945 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit AB180_19950 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AB180_19955 ENOG4105DVI reductase, NrfD AB180_19960 ENOG4108QKW cytochrome c-type biogenesis protein AB180_19970 ENOG4108W0S formate-dependent nitrite reductase complex AB180_19975 ENOG4105CK2 sodium dicarboxylate symporter AB180_19980 ENOG41082ND Uncharacterized protein yjcO AB180_19985 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_19990 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_19995 ENOG4105ETP RND efflux system, outer membrane lipoprotein AB180_20000 ENOG4108MI0 Resistance protein AB180_20005 ENOG4105J12 Multidrug resistance protein mdtN AB180_20015 ENOG4105EUZ Beta-lactamase domain protein AB180_20030 ENOG4105D2N Aldolase AB180_20040 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AB180_20045 ENOG4105CNN ABC, transporter AB180_20050 ENOG4105C2J ABC transporter AB180_20060 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 AB180_20065 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein AB180_20070 ENOG410849A acetyltransferase, (GNAT) family AB180_20075 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AB180_20080 ENOG4105FD8 phosphonate metabolism protein PhnM AB180_20085 ENOG4105HRV phosphonate c-p lyase system protein phnl AB180_20090 ENOG4105ENV phosphonate C-P lyase system protein PhnK AB180_20095 ENOG4105FT8 Phosphonate metabolism AB180_20100 ENOG4105EKV Phosphonate metabolism protein AB180_20105 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH AB180_20110 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG AB180_20115 ENOG4107RJJ Transcriptional regulator AB180_20125 ENOG4105EHI Phosphonate ABC transporter, periplasmic AB180_20130 ENOG4105D5T phosphonate abc transporter AB180_20135 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase AB180_20140 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AB180_20145 ENOG4108F5E vimentin AB180_20150 ENOG4108YIV AB180_20155 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) AB180_20160 ENOG4105CSH Transporter AB180_20170 ENOG4105ECM Sensor protein basS pmrB AB180_20175 ENOG4105XJC Two component transcriptional regulator (Winged helix family AB180_20180 ENOG4105DIJ Phosphoethanolamine transferase AB180_20185 ENOG4105D5Q Arginine ornithine antiporter AB180_20190 ENOG4106ZGR Transcriptional regulator AB180_20195 ENOG4105CXN decarboxylase AB180_20200 ENOG4108K2B transcriptional regulator AB180_20205 ENOG4105F8D glycoside hydrolase family 4 AB180_20210 ENOG4105CT4 transporter AB180_20220 ENOG4108R5S membrane AB180_20225 ENOG4107GFK fumarate AB180_20230 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AB180_20235 ENOG4108MRH transcriptional regulatory protein AB180_20240 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AB180_20270 ENOG4105CEY Amp-dependent synthetase and ligase AB180_20280 ENOG4108SIC Transcriptional regulator AB180_20285 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AB180_20295 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AB180_20300 ENOG4108IJ0 Aspartate ammonia-lyase AB180_20305 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 AB180_20310 ENOG4105DVH amino acid AB180_20320 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AB180_20325 ENOG4108ZVF (LipO)protein AB180_20335 ENOG4105MTB Uncharacterized protein YjeJ AB180_20340 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AB180_20385 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AB180_20390 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) AB180_20395 ENOG4105E33 succinate dehydrogenase AB180_20400 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AB180_20405 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AB180_20410 ENOG4107SC7 Inner membrane transporter yjeM AB180_20415 ENOG4105EGS Mechanosensitive ion channel AB180_20420 ENOG4105DJ4 phosphatidylserine decarboxylase AB180_20450 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AB180_20455 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AB180_20460 ENOG4105K8N protein family UPF0079, ATPase AB180_20465 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AB180_20470 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AB180_20480 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AB180_20485 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AB180_20490 ENOG4107QJR hflk protein AB180_20495 ENOG4105EPW hflc protein AB180_20505 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AB180_20515 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AB180_20520 ENOG4105C2N RNA methyltransferase TrmH family group 3 AB180_20525 ENOG4105CSU acyl-Coa dehydrogenase AB180_20530 ENOG4105S17 UPF0379 protein yjfN AB180_20535 ENOG4105WSB biofilm stress and motility protein A AB180_20540 ENOG4108MXZ Esterase AB180_20545 ENOG4105DW5 Transcriptional regulator AB180_20560 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport AB180_20585 ENOG4105KIT UPF0379 protein yjfY AB180_20590 ENOG4105EJ9 Membrane AB180_20605 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AB180_20610 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AB180_20620 ENOG4105FHY Opacity-associated protein A AB180_20625 ENOG4108V1T peptidylprolyl cis-trans isomerase AB180_20630 ENOG4105C85 amino acid AB180_20635 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) AB180_20640 ENOG4105C8Q Methyl-accepting chemotaxis AB180_20645 ENOG4105DXC membrane AB180_20655 ENOG4105ECR NmrA family AB180_20660 ENOG4105KVH Transcriptional regulator AB180_20665 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AB180_20670 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AB180_20675 ENOG4108UUE Transcriptional regulator AB180_20680 ENOG41061GZ Protein of unknown function (DUF1107) AB180_20685 ENOG4105C37 (CBS) domain AB180_20695 ENOG4105CFU surface antigen AB180_20700 ENOG4105MA0 exported protein AB180_20705 ENOG4108ZHD aig2 family AB180_20710 ENOG4105F0N pyrophosphate phospho-hydrolase AB180_20715 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator AB180_20720 ENOG4105C2J ABC transporter AB180_20725 ENOG4107R9N ABC transporter AB180_20730 ENOG41062B0 ABC transporter, permease AB180_20745 ENOG4105DFU Cell wall formation (By similarity) AB180_20755 ENOG4105CMS peptidase U62, modulator of DNA gyrase AB180_20760 ENOG4108XVM Cytochrome b(562) AB180_20790 ENOG41069H0 dihydroorotase EC 3.5.2.3 AB180_20805 ENOG4105EMD TRANSCRIPTIONal AB180_20815 ENOG4105K4U addiction module toxin, RelE StbE family AB180_20820 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AB180_20825 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AB180_20830 ENOG4105DM4 PTS System AB180_20835 ENOG4107QW3 Sucrose phosphorylase AB180_20840 ENOG4105C8I hydrolase, family 38 AB180_20850 ENOG4106KNT transcriptional regulator AB180_20860 ENOG4105CG3 alpha amylase, catalytic region AB180_20865 ENOG4105C5Y PTS System AB180_20870 ENOG4105D4X repressor AB180_20880 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AB180_20890 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AB180_20895 ENOG4105KME endoribonuclease L-psp AB180_20900 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) AB180_20910 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) AB180_20915 ENOG4105CSX c4-dicarboxylate anaerobic carrier AB180_20920 ENOG4105DBV ornithine carbamoyltransferase AB180_20925 ENOG4105C5B carbamate kinase AB180_20930 ENOG4105CEU Arginine dihydrolase AB180_20935 ENOG4105XEP YhcH YjgK YiaL family protein AB180_20945 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) AB180_20950 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase AB180_20960 ENOG4108MJ3 acetyltransferase AB180_20965 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AB180_20970 ENOG4105MYG DNA polymerase iii, chi subunit AB180_20975 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AB180_20980 ENOG4108M8S permease YjgP YjgQ family protein AB180_20985 ENOG4108K5H permease YjgP YjgQ family protein AB180_20990 ENOG4105D7A ATP-binding protein AB180_20995 ENOG4105DQ4 alcohol dehydrogenase AB180_21065 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AB180_21110 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AB180_21115 ENOG4107QR9 Iron-sulfur cluster binding protein AB180_21120 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AB180_21125 ENOG4107EFN gluconate transport system permease 3 AB180_21135 ENOG4105DEI Mannitol dehydrogenase AB180_21140 ENOG4105C6F GntR Family Transcriptional Regulator AB180_21150 ENOG4105FCK Membrane AB180_21155 ENOG4105CBP Major Facilitator AB180_21165 ENOG4106BRA Membrane AB180_21170 ENOG410642W LysR family Transcriptional regulator AB180_21175 ENOG4105CK2 sodium dicarboxylate symporter AB180_21180 ENOG4105C28 cystathionine AB180_21185 ENOG41083G8 Multidrug resistance protein MdtM AB180_21205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AB180_21215 ENOG4105EFX secretion protein, HlyD family AB180_21225 ENOG4105CKI cobalamin synthesis protein AB180_21230 ENOG4105VCD cytoplasmic protein AB180_21235 ENOG4105D22 carbon starvation protein AB180_21240 ENOG4105C8Q Methyl-accepting chemotaxis AB180_21245 ENOG4105XYF acetyltransferase AB180_21250 ENOG4108I5G Major Facilitator superfamily AB180_21255 ENOG410617M Transcriptional regulator AB180_21260 ENOG4105CPQ Dehydrogenase AB180_21265 ENOG4107QZW Altronate oxidoreductase AB180_21275 ENOG4105RI1 glycoprotein receptor AB180_21280 ENOG4106CVF DNA replication protein AB180_21290 ENOG4107XM3 UPF0442 protein AB180_21295 ENOG4105DWK Membrane AB180_21300 ENOG4108N8T regulatoR AB180_21305 ENOG4108T94 DNA-binding transcriptional activator BglJ AB180_21310 ENOG4108UIN ybak prolyl-trna synthetase associated region AB180_21315 ENOG4105CK1 PTS System AB180_21320 ENOG4108819 ferric iron reductase AB180_21325 ENOG4105BZU Histidine kinase AB180_21330 ENOG4105YBH Protein of unknown function (DUF1435) AB180_21350 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AB180_21355 ENOG4108WPU DNA polymerase III subunit psi AB180_21360 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AB180_21365 ENOG4105PAD Hydrolase AB180_21370 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) AB180_21375 ENOG4105K3G Periplasmic Protein AB180_21380 ENOG4108NRW Phospholipase, patatin family AB180_21385 ENOG4105EYA deoxyribonuclease AB180_21390 ENOG41076CZ activating enzyme AB180_21395 ENOG4105G0K glycine radical enzyme YjjI family AB180_21425 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) AB180_21430 ENOG4105EAC phosphoserine phosphatase AB180_21435 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AB180_21440 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase AB180_21445 ENOG4105C5H ABC transporter AB180_21450 ENOG4107SC1 transglycosylase AB180_21460 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AB180_21465 ENOG4105CVJ phosphoglycerate mutase AB180_21470 ENOG4105UEI Transcriptional Regulator AraC Family AB180_21475 ENOG4108RH0 Crea protein AB180_21480 ENOG4105E3W Two component transcriptional regulator (Winged helix family AB180_21485 ENOG4105EB3 Histidine kinase AB180_21490 ENOG4105CT7 inner membrane cred family protein AB180_21495 ENOG41065U4 response regulator AB180_21500 ENOG4106FVC RNA methyltransferase AB180_21510 ENOG4105CFH Aspartokinase AB180_21515 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AB180_21520 ENOG4105D98 threonine synthase AB180_21525 ENOG4105D1Q UPF0246 protein AB180_21530 ENOG4105BZG amino acid carrier protein AB180_21540 ENOG4108RIR Molybdenum cofactor biosynthesis protein AB180_21550 ENOG4106HK8 GPR1 FUN34 yaaH family protein AB180_21555 ENOG4108QUJ UPF0174 protein YaaW AB180_21565 ENOG4105CFG Acts as a chaperone (By similarity) AB180_21580 ENOG41061MV Arylsulfatase AB180_21585 ENOG4105C4X radical SAM domain protein AB180_21600 ENOG41063Z6 transcriptional regulator, lysR family AB180_21620 ENOG4105DTN riboflavin biosynthesis protein ribF AB180_21625 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AB180_21635 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AB180_21640 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AB180_21645 ENOG4105DU0 nucleoside hydrolase AB180_21650 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AB180_21655 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AB180_21660 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AB180_21665 ENOG4108XNW Transcriptional activatory protein CaiF AB180_21710 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AB180_21715 ENOG4105WQV ferredoxin-like protein AB180_21720 ENOG4105C54 Major Facilitator superfamily AB180_21725 ENOG4105M5B (LipO)protein AB180_21745 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) AB180_21750 ENOG4105NWN ApaG protein AB180_21755 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AB180_21760 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) AB180_21770 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AB180_21780 ENOG4105D3G Pseudouridine synthase AB180_21785 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) AB180_21790 ENOG4105CQ2 DNA polymerase AB180_21800 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AB180_21820 ENOG4108KF1 Membrane AB180_21830 ENOG4106SMU thiamine transporter membrane protein AB180_21835 ENOG4105DP9 ABC transporter AB180_21850 ENOG4105S8Q sugar efflux transporter AB180_21855 ENOG4105CHR reductase AB180_21860 ENOG4105C57 major facilitator superfamily AB180_21865 ENOG4105K2J Transcriptional regulator AB180_21890 ENOG41064T2 transcriptional regulator, lysR family AB180_21895 ENOG4105C7K acetolactate synthase AB180_21900 ENOG4108ZP8 Acetolactate synthase small subunit AB180_21905 ENOG4107B7Y DNA-binding transcriptional regulator FruR AB180_21910 ENOG4108V6E Cell division protein mraZ AB180_21920 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AB180_21925 ENOG4105CJN penicillin-binding protein AB180_21930 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AB180_21935 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AB180_21940 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AB180_21945 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AB180_21950 ENOG4105CNI cell division protein FtsW AB180_21955 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AB180_21965 ENOG4105CPF Cell wall formation (By similarity) AB180_21970 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AB180_21975 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AB180_21980 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AB180_21990 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) AB180_22000 ENOG4105M6F mutator MutT protein AB180_22005 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) AB180_22010 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) AB180_22015 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AB180_22020 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AB180_22025 ENOG4105D7Q type ii secretion system AB180_22030 ENOG4107QHF type ii secretion system protein e AB180_22035 ENOG4108ZUW Major pilin subunit AB180_22040 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AB180_22050 ENOG4106A72 regulatory protein AmpE AB180_22055 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) AB180_22060 ENOG4105CT4 transporter AB180_22065 ENOG4105C85 amino acid AB180_22070 ENOG41073TP transcriptional regulator AB180_22075 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AB180_22080 ENOG4107QSN dihydrolipoamide acetyltransferase AB180_22085 ENOG4107QN2 dihydrolipoyl dehydrogenase AB180_22100 ENOG4108NST exported protein AB180_22105 ENOG4107QIJ Aconitate hydratase 2 AB180_22110 ENOG4108ZIG UPF0231 protein AB180_22115 ENOG4108ZRK uncharacterized protein yacC AB180_22120 ENOG4105E3B Multicopper oxidase AB180_22125 ENOG4105C8Q Methyl-accepting chemotaxis AB180_22130 ENOG4108UGV hypoxanthine phosphoribosyltransferase AB180_22135 ENOG41077A9 carbonic anhydrase AB180_22140 ENOG4105DA5 (ABC) transporter AB180_22145 ENOG4105E3A (ABC) transporter AB180_22150 ENOG4108YTN IIa component AB180_22155 ENOG4107BJW polysaccharide deacetylase AB180_22175 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AB180_22180 ENOG4105DJ0 Poly(A) Polymerase AB180_22185 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) AB180_22190 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AB180_22195 ENOG4105PW4 Sugar fermentation stimulation protein homolog AB180_22200 ENOG4107XID 2'-5' rna ligase AB180_22205 ENOG4105CQ7 ATP-dependent helicase AB180_22210 ENOG4105BZ4 penicillin-binding protein AB180_22220 ENOG4108NAE Fimbrial chaperone protein AB180_22225 ENOG4105CW0 outer membrane usher protein AB180_22230 ENOG4108WDE Fimbrial protein AB180_22235 ENOG4105E0K tonB-dependent siderophore receptor AB180_22240 ENOG4105E0A ABC, transporter AB180_22245 ENOG4105J76 Periplasmic binding protein AB180_22250 ENOG4105S6R Iron-hydroxamate transporter permease subunit AB180_22260 ENOG4105CMQ Chloride channel AB180_22265 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AB180_22270 ENOG4105EN6 Membrane AB180_22275 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AB180_22280 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) AB180_22285 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein AB180_22290 ENOG4105C0H protease AB180_22295 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AB180_22305 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) AB180_22310 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) AB180_22315 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AB180_22330 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) AB180_22340 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AB180_22350 ENOG4105KNE Phosphatidate cytidylyltransferase AB180_22365 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AB180_22370 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AB180_22385 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AB180_22390 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AB180_22395 ENOG4105C0B DNA polymerase III (alpha subunit) AB180_22400 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) AB180_22405 ENOG4105CXN decarboxylase AB180_22410 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AB180_22415 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AB180_22420 ENOG4105M1T rho-binding antiterminator AB180_22430 ENOG4108VWS Yaeq family AB180_22435 ENOG4108YZN class I peptide chain release factor AB180_22440 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AB180_22445 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AB180_22450 ENOG4108R96 Methyltransferase, YaeB family AB180_22455 ENOG4108R8X outer membrane lipoprotein AB180_22460 ENOG4105D01 (LipO)protein AB180_22465 ENOG4108UMI ABC transporter, permease AB180_22470 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AB180_22475 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AB180_22505 ENOG4105CV8 reductase AB180_22510 ENOG4105HEI LysR family (Transcriptional regulator AB180_22515 ENOG4105F27 Major Facilitator AB180_22525 ENOG4105F2W methyltransferase AB180_22530 ENOG4105E9H Lytic Murein transglycosylase AB180_22535 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AB180_22540 ENOG4105D1A Methyltransferase AB180_22545 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AB180_22550 ENOG4107RZZ dna polymerase iii epsilon subunit AB180_22565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AB180_22570 ENOG4108TH4 Major fimbrial subunit AB180_22580 ENOG4106PG1 outer membrane usher protein AB180_22585 ENOG4108FZ9 Chaperone AB180_22595 ENOG4108MDY Fimbrial AB180_22610 ENOG4105CMB EAL domain-containing protein AB180_22620 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AB180_22625 ENOG4107QPN acyl-Coa dehydrogenase AB180_22635 ENOG4105E7A Glutamine amidotransferase AB180_22640 ENOG4105F7V ErfK ybiS ycfS ynhG family protein AB180_22645 ENOG4108YS0 lipoprotein YafL AB180_22680 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AB180_22685 ENOG4105CIN aminoacyl-histidine dipeptidase AB180_22690 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) AB180_22700 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) AB180_22710 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AB180_22715 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) AB180_22720 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AB180_22740 ENOG4106PYX Receptor AB180_22760 ENOG4108M8H domain protein AB180_22775 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures AB180_22785 ENOG4105ZS6 Protein of unknown function (DUF987) AB180_22790 ENOG4108XS9 dna repair protein AB180_22795 ENOG4105MFG Antirestriction protein AB180_22800 ENOG4105C94 Transporter AB180_22805 ENOG4105EXU Membrane AB180_22815 ENOG4106J9S Prophage AB180_22830 ENOG4108KZE transcriptional regulator AB180_22835 ENOG4106H6R UPF0380 protein AB180_22840 ENOG4108MXD gtp-binding protein AB180_22855 ENOG4105PBD transposase, IS3 IS911 family protein AB180_22860 ENOG4105F9F transposase AB180_22885 ENOG4108M0B Sucrose porin AB180_22900 ENOG4108YXQ IS66 Orf2 family protein AB180_22905 ENOG4105E5H Transposase AB180_22920 ENOG4105JXR Protein of unknown function (DUF3296) AB180_22935 ENOG41067CV Integrase AB180_22950 ENOG4105C87 Aminotransferase class I and II AB180_22955 ENOG4105DFD Na H antiporter AB180_22980 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AB180_22985 ENOG4105C4M (Ubiquinol oxidase) subunit I AB180_22990 ENOG4105MVP hydrogenase-1 operon protein HyaF AB180_22995 ENOG4108VXY Hydrogenase-1 operon protein HyaE AB180_23000 ENOG4108USZ hydrogenase AB180_23005 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit AB180_23020 ENOG4105CJP fad dependent oxidoreductase AB180_23025 ENOG4105C26 Dehydrogenase AB180_23030 ENOG4107VRI Transcriptional regulator AB180_23035 ENOG4108Z86 Glutamine amidotransferase AB180_23040 ENOG4105CFQ glutamine synthetase AB180_23045 ENOG4105CUB amino acid AB180_23050 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AB180_23060 ENOG4105BZU Histidine kinase AB180_23065 ENOG4105DWY Agmatine deiminase AB180_23070 ENOG4107R7Y intracellular protease Pfpi family AB180_23075 ENOG4105DTA methyltransferase AB180_23085 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AB180_23090 ENOG4105CEE C4-dicarboxylate transporter AB180_23110 ENOG4105ETT transcriptional Regulator, LysR family AB180_23135 ENOG4105E0A ABC, transporter AB180_23140 ENOG4105DQ5 transport system permease protein AB180_23145 ENOG4108U1V ABC transporter, permease AB180_23155 ENOG4106KNT transcriptional regulator AB180_23160 ENOG4105HEE Binding Domain protein AB180_23165 ENOG4105BZU Histidine kinase AB180_23170 ENOG4105E82 cytochrome subunit of dehydrogenase AB180_23175 ENOG4105TDT uncharacterized protein yahO AB180_23180 ENOG4108JU7 Transcriptional regulator AB180_23185 ENOG4105CR4 methylisocitrate lyase AB180_23190 ENOG4105BZN citrate synthase AB180_23195 ENOG4105DXD 2-methylcitrate dehydratase AB180_23200 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AB180_23205 ENOG4108UW5 maltose o-acetyltransferase AB180_23215 ENOG4105CNT hydrolase family 2 AB180_23220 ENOG4105ETE Transcriptional regulator (LacI family AB180_23235 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein AB180_23240 ENOG4105N0E Protein of unknown function (DUF2543) AB180_23265 ENOG4108K2P TRANSCRIPTIONal AB180_23275 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) AB180_23300 ENOG4108SC4 )-transporter AB180_23305 ENOG4108IQI permease AB180_23310 ENOG4107QK5 Homocysteine s-methyltransferase AB180_23315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AB180_23320 ENOG4107RCV ABC transporter, permease AB180_23325 ENOG4105C4Y ABC transporter AB180_23330 ENOG4105CXY transporter AB180_23335 ENOG4105BZU Histidine kinase AB180_23340 ENOG4108KX4 response regulator AB180_23345 ENOG4106FTQ Taurine ABC transporter, periplasmic AB180_23350 ENOG4108ETV ABC transporter AB180_23355 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AB180_23360 ENOG4105E2B Taurine dioxygenase AB180_23365 ENOG4105D52 delta-aminolevulinic acid dehydratase AB180_23370 ENOG4108NSE outer membrane autotransporter barrel AB180_23375 ENOG4108PNB DNA-binding transcriptional regulator AB180_23380 ENOG4107R6D beta-lactam binding protein AmpH AB180_23385 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 AB180_23390 ENOG4107QS8 (LipO)protein AB180_23395 ENOG4105FR5 inner membrane protein YaiY AB180_23400 ENOG4105UNH Membrane AB180_23405 ENOG4105CPF Cell wall formation (By similarity) AB180_23420 ENOG4105G6Z alkaline phosphatase AB180_23425 ENOG4105VIF phosphate starvation-inducible protein AB180_23430 ENOG4105BZU Histidine kinase AB180_23435 ENOG4105II7 pyrroline-5-carboxylate reductase AB180_23440 ENOG4108UPT UPF0178 protein AB180_23450 ENOG4105SS3 AB180_23455 ENOG4105HBA AroM protein AB180_23470 ENOG4105DKQ ROK family AB180_23475 ENOG4105F27 Major Facilitator AB180_23480 ENOG4105EYH Exonuclease AB180_23485 ENOG4107RH8 nuclease SbcCD subunit D AB180_23495 ENOG4105BZU Histidine kinase AB180_23500 ENOG4105CWM branched-chain amino acid transport system II carrier protein AB180_23505 ENOG4105C85 amino acid AB180_23510 ENOG4107R28 alpha amylase, catalytic region AB180_23515 ENOG4105EQ1 Transcriptional regulator AB180_23520 ENOG4105CHJ isochorismatase hydrolase AB180_23530 ENOG4105EFZ amidohydrolase AB180_23535 ENOG4105D3R alkyl hydroperoxide reductase AB180_23550 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AB180_23555 ENOG4105VIE preprotein translocase, subunit YajC AB180_23560 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AB180_23565 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AB180_23580 ENOG4105DRB nucleoside-specific channel-forming protein AB180_23585 ENOG4108KIC (LipO)protein AB180_23595 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AB180_23600 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AB180_23605 ENOG4107YIM Involved in the transcription termination process (By similarity) AB180_23610 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AB180_23615 ENOG4108ZAI phosphatidylglycerophosphatase a AB180_23620 ENOG4105CPC Aldo Keto reductase AB180_23625 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) AB180_23630 ENOG4105CTB Polyprenyl synthetase AB180_23650 ENOG4107S0N DJ-1 family AB180_23655 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AB180_23660 ENOG4108VPT UPF0234 protein AB180_23665 ENOG4107RDB Major Facilitator AB180_23675 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AB180_23680 ENOG4105CCU oxidase (Subunit III) AB180_23685 ENOG4105BZ9 Cytochrome C oxidase, subunit I AB180_23690 ENOG4105E2S oxidase) subunit II AB180_23695 ENOG4105EYM Major Facilitator superfamily AB180_23700 ENOG4105IEY (LipO)protein AB180_23705 ENOG4105M85 Bola protein AB180_23720 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AB180_23725 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AB180_23730 ENOG4105K70 DNA-binding protein AB180_23735 ENOG4105EIN peptidylprolyl cis-trans isomerase AB180_23740 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AB180_23745 ENOG4108TGP Thioesterase superfamily protein AB180_23750 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AB180_23755 ENOG4108NFA extracellular solute-binding protein AB180_23760 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) AB180_23770 ENOG4108XM1 transcriptional regulator AsnC family AB180_23775 ENOG4105BZ1 (ABC) transporter AB180_23780 ENOG4105BZ1 (ABC) transporter AB180_23785 ENOG4108YZA Nitrogen regulatory protein pii AB180_23790 ENOG4105BZU Histidine kinase AB180_23795 ENOG4105C29 acyl-CoA thioesterase AB180_23800 ENOG4108MNP Glycoprotein polysaccharide metabolism AB180_23805 ENOG41080UX Methyltransferase AB180_23820 ENOG4107U9B transcriptional regulator AB180_23825 ENOG4108VW9 Membrane AB180_23830 ENOG4105KCV RNA signal recognition particle 4.5S RNA AB180_23835 ENOG41066DG (EAL) domain protein AB180_23840 ENOG4105NRA 50s ribosomal protein l31 type b AB180_23845 ENOG4105GSJ Inner membrane protein ylaC AB180_23850 ENOG4108UW5 maltose o-acetyltransferase AB180_23860 ENOG4108UKR Biofilm formation regulator YbaJ AB180_23865 ENOG4105BZS acriflavin resistance protein AB180_23870 ENOG4105C1P efflux transporter, rnd family, mfp subunit AB180_23875 ENOG4108IG5 Transcriptional regulator AB180_23880 ENOG4105EGS Mechanosensitive ion channel AB180_23885 ENOG4108URS primosomal replication protein n'' AB180_23890 ENOG4105WD1 Membrane AB180_23895 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AB180_23900 ENOG4107QMP dna polymerase iii subunits gamma and tau AB180_23905 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AB180_23910 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AB180_23915 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AB180_23935 ENOG4107RE1 Inosine-guanosine kinase AB180_23940 ENOG4105CKD glutathione-regulated potassium-efflux system protein AB180_23945 ENOG4105EU0 Major facilitator Superfamily AB180_23950 ENOG4105CGH 5'-nucleotidase AB180_23955 ENOG4108Z66 YbaK ebsC protein AB180_23960 ENOG4105MBR gumn family AB180_23965 ENOG4105C59 p-type ATPase AB180_23975 ENOG4105EHG Permease protein AB180_23985 ENOG41090JE Utilization Protein AB180_23990 ENOG4105D4P Coproporphyrinogen iii oxidase AB180_23995 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AB180_24005 ENOG4108Z6Z Transcriptional regulator AB180_24020 ENOG4105G5H Membrane AB180_24025 ENOG4107QX8 SPFH domain, Band 7 family protein AB180_24030 ENOG41083J0 (ABC) transporter AB180_24035 ENOG4105C4B ABC transporter, permease AB180_24040 ENOG4107QR8 Thioredoxin AB180_24045 ENOG4105E1F short-chain dehydrogenase reductase AB180_24050 ENOG4108UJV acyl-CoA thioesterase i AB180_24055 ENOG4108I0Y (ABC) transporter AB180_24060 ENOG4105CV6 ABC transporter, permease AB180_24065 ENOG4105FCK Membrane AB180_24070 ENOG4105D01 (LipO)protein AB180_24080 ENOG4108UMI ABC transporter, permease AB180_24120 ENOG4108ZQS transposase AB180_24130 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AB180_24135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AB180_24145 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AB180_24155 ENOG4105DTE Xanthine uracil vitamin C permease AB180_24160 ENOG4105BZW Glycerate kinase AB180_24165 ENOG4105S0E allantoin catabolism protein AB180_24170 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AB180_24175 ENOG4105DG4 malate L-lactate dehydrogenase AB180_24180 ENOG4107R1Q Membrane protein FdrA AB180_24185 ENOG4107REC cytoplasmic protein AB180_24190 ENOG4105G5A Protein of unknown function (DUF2877) AB180_24195 ENOG4105C5B carbamate kinase AB180_24200 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AB180_24205 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AB180_24215 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AB180_24225 ENOG4105S2T inner membrane protein YbcI AB180_24230 ENOG4105WQ3 Rna-binding protein AB180_24235 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AB180_24240 ENOG4108WDE Fimbrial protein AB180_24245 ENOG4105NJT Fimbrial protein AB180_24250 ENOG4108AF8 Chaperone AB180_24255 ENOG4105CW0 outer membrane usher protein AB180_24260 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) AB180_24265 ENOG4108ZI2 Fimbrial protein AB180_24270 ENOG4108Q9V regulatoR AB180_24275 ENOG4106721 fimbriae Y protein AB180_24280 ENOG4106KCD HTH_LUXR AB180_24290 ENOG4105BZU Histidine kinase AB180_24295 ENOG4108SV3 Tmao reductase system periplasmic protein tort AB180_24300 ENOG4106WF9 DNA-binding transcriptional regulator TorR AB180_24305 ENOG4105CUW cytochrome C-TYPE protein AB180_24310 ENOG4108EM1 reductase AB180_24320 ENOG4108RW8 Universal stress protein F AB180_24325 ENOG4105CUW cytochrome C-TYPE protein AB180_24330 ENOG4107QY8 reductase AB180_24335 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AB180_24350 ENOG4105GR3 Histidine kinase AB180_24355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AB180_24360 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AB180_24365 ENOG410624V efflux system protein AB180_24370 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AB180_24375 ENOG4108IJF Heavy metal efflux pump, CzcA AB180_24380 ENOG4108K01 transcriptional regulator AB180_24385 ENOG4107QN2 dihydrolipoyl dehydrogenase AB180_24390 ENOG41066GK UPF0379 protein ykgI AB180_24395 ENOG4108KBJ Inner membrane protein YkgB AB180_24410 ENOG4105BZU Histidine kinase AB180_24430 ENOG4105C85 amino acid AB180_24435 ENOG4105EAA nucleoside AB180_24455 ENOG4105CUY Mechanosensitive ion channel AB180_24460 ENOG4108RCM Nitroreductase AB180_24465 ENOG4105MSB protein, conserved in bacteria AB180_24470 ENOG41067SE Tetr family transcriptional regulator AB180_24480 ENOG4105HFT AraC family transcriptional regulator AB180_24485 ENOG4105WQ6 Membrane AB180_24490 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) AB180_24500 ENOG4108TSE Transferase AB180_24505 ENOG4107RNH Outer membrane receptor FepA AB180_24510 ENOG4105E93 esterase AB180_24515 ENOG41085A6 mbth domain-containing protein AB180_24520 ENOG4105C0W non-ribosomal peptide synthetase AB180_24525 ENOG4108QY5 Ferric enterobactin transport protein AB180_24530 ENOG4105E0A ABC, transporter AB180_24535 ENOG4105TVJ transport system, permease AB180_24540 ENOG4105DQ5 transport system permease protein AB180_24545 ENOG4105E8G Major facilitator Superfamily AB180_24550 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein AB180_24555 ENOG4105E4F Isochorismate synthase AB180_24560 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AB180_24565 ENOG4105WQI isochorismatase AB180_24570 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AB180_24580 ENOG4105D22 carbon starvation protein AB180_24585 ENOG4105VCD cytoplasmic protein AB180_24590 ENOG4107SCQ Iron-containing alcohol dehydrogenase AB180_24595 ENOG4105CHM Aminotransferase AB180_24600 ENOG4105GTN ParB Domain Protein Nuclease AB180_24605 ENOG4105BZV Phosphoadenosine phosphosulfate reductase AB180_24610 ENOG4105DQS Transcriptional regulator AB180_24615 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase AB180_24620 ENOG4105D3R alkyl hydroperoxide reductase AB180_24625 ENOG4108JU3 Alkyl hydroperoxide reductase AB180_24635 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AB180_24640 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AB180_24650 ENOG4108U51 Universal stress protein AB180_24655 ENOG4105NXH GreA GreB family elongation factor AB180_24670 ENOG4105KTS ribonuclease AB180_24675 ENOG4107QPK )-transporter AB180_24680 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase AB180_24685 ENOG4105YGP holo-ACP synthase CitX AB180_24690 ENOG4105CHY citrate lyase, alpha AB180_24695 ENOG4105CI0 Citrate lyase AB180_24705 ENOG4105DUA (citrate (pro-3S)-lyase ligase AB180_24710 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AB180_24715 ENOG4106YYS transcriptional regulatory protein AB180_24720 ENOG4105CEE C4-dicarboxylate transporter AB180_24725 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) AB180_24730 ENOG4105VEQ Cold shock protein AB180_24740 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AB180_24755 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) AB180_24760 ENOG4108Z43 UPF0250 protein AB180_24765 ENOG4105DZ1 carboxypeptidase AB180_24770 ENOG4105K6T rare lipoprotein A AB180_24775 ENOG4105CNI cell division protein FtsW AB180_24780 ENOG4105CJN penicillin-binding protein AB180_24785 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AB180_24790 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AB180_24795 ENOG4108TGR phosphatase AB180_24800 ENOG4107QZB decarboxylase AB180_24805 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AB180_24810 ENOG4105DJF DNA polymerase III, delta' subunit AB180_24820 ENOG4105C8T Leucyl-tRNA synthetase AB180_24825 ENOG4107PAI alpha helical protein AB180_24835 ENOG4105CDA abc transporter atp-binding protein AB180_24840 ENOG4105DRP amino acid AbC transporter AB180_24845 ENOG4105EAD ABC transporter AB180_24850 ENOG4107RP9 extracellular solute-binding protein, family 3 AB180_24855 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AB180_24860 ENOG4108JU5 Magnesium and cobalt efflux protein AB180_24870 ENOG4105C9A Phoh family AB180_24880 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AB180_24925 ENOG4105CAQ asparagine synthetase AB180_24930 ENOG4105D4U had-superfamily hydrolase, subfamily iia AB180_24935 ENOG4105E2R ROK family AB180_24940 ENOG4105CE4 GlcNAc 6-P deacetylase AB180_24950 ENOG4105CI1 PTS System AB180_24960 ENOG4105J5J Outer membrane porin AB180_24965 ENOG4105GX6 (LipO)protein AB180_24980 ENOG4107EFR Flavocytochrome c AB180_24985 ENOG4106P55 Transcriptional regulator AB180_24990 ENOG41090R7 Ferric uptake AB180_24995 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AB180_25000 ENOG4105NNH LexA regulated protein AB180_25005 ENOG4105EV9 Alpha Beta Hydrolase AB180_25010 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AB180_25015 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AB180_25020 ENOG4105EEX Two component transcriptional regulator (Winged helix family AB180_25025 ENOG4105C08 Histidine kinase AB180_25050 ENOG4105XIQ Protein of unknown function (DUF2517) AB180_25055 ENOG4107SEY Conserved Protein AB180_25060 ENOG4105CVP deoxyribo-dipyrimidine photolyase AB180_25065 ENOG4105DNE Transposase AB180_25075 ENOG4107QNR UPF0135 protein AB180_25080 ENOG4105P4J Allophanate hydrolase, subunit 1 AB180_25085 ENOG4107R7A Allophanate hydrolase subunit 2 AB180_25090 ENOG4105E7W lamb ycsf family protein AB180_25105 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AB180_25115 ENOG4108KK1 membrane protein AbrB duplication AB180_25120 ENOG4108VBH Uncharacterized protein conserved in bacteria (DUF2251) AB180_25135 ENOG4105GMB type VI secretion system effector, hcp1 family AB180_25140 ENOG4105BZN citrate synthase AB180_25145 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AB180_25150 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AB180_25155 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AB180_25160 ENOG4105E33 succinate dehydrogenase AB180_25165 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AB180_25170 ENOG4105C7S Dehydrogenase AB180_25180 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AB180_25185 ENOG4107XVH Transcriptional regulator AB180_25190 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AB180_25195 ENOG4105ETT transcriptional Regulator, LysR family AB180_25200 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AB180_25205 ENOG4107GFK fumarate AB180_25210 ENOG4105CSV Glutaminase AB180_25235 ENOG4105DJI Methylaspartate mutase, E subunit AB180_25245 ENOG4107WFU Glutamate mutase subunit sigma AB180_25250 ENOG4105C4M (Ubiquinol oxidase) subunit I AB180_25255 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AB180_25260 ENOG4105KJB cyd operon protein YbgE AB180_25265 ENOG4107YD3 Thioesterase AB180_25270 ENOG4105E02 MotA TolQ exbB proton channel AB180_25275 ENOG4105M8F Biopolymer transport protein exbD tolR AB180_25280 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AB180_25290 ENOG4105KCK Peptidoglycan-associated lipoprotein AB180_25295 ENOG4105UFD tol-pal system protein YbgF AB180_25330 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AB180_25335 ENOG4105PGM cation diffusion facilitator family transporter AB180_25340 ENOG4105JND homeobox protein AB180_25345 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AB180_25350 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AB180_25355 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AB180_25360 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AB180_25365 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AB180_25370 ENOG4105CMR udp-glucose 4-epimerase AB180_25375 ENOG4105DKW ABC transporter AB180_25380 ENOG4105F4R Transcriptional regulator mode AB180_25385 ENOG410680R Protein of unknown function (DUF2592) AB180_25390 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AB180_25395 ENOG4105E0C molybdate abc transporter AB180_25405 ENOG4108K4B hydrolase AB180_25410 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AB180_25420 ENOG4105NBR Pectinesterase AB180_25430 ENOG41088SP formiminoglutamate hydrolase AB180_25440 ENOG4105CGP Urocanate hydratase AB180_25445 ENOG4105C84 Histidine ammonia-lyase AB180_25450 ENOG4108V1U phospholipid-binding protein AB180_25455 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AB180_25460 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AB180_25465 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AB180_25470 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AB180_25475 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AB180_25480 ENOG4108IV0 ABC, transporter AB180_25485 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AB180_25490 ENOG4105CHW UPF0052 protein AB180_25500 ENOG4108RIR Molybdenum cofactor biosynthesis protein AB180_25505 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AB180_25510 ENOG4105M00 molybdopterin converting factor, subunit 1 AB180_25515 ENOG4108ZAF Molybdopterin AB180_25520 ENOG4105HFZ Membrane AB180_25525 ENOG4107UXM Membrane AB180_25530 ENOG4105DZQ phospholipase D Transphosphatidylase AB180_25535 ENOG4105X23 Endonuclease Exonuclease phosphatase AB180_25540 ENOG4105I9U inner membrane protein ybhQ AB180_25545 ENOG4107QWP ABC-2 type transporter AB180_25550 ENOG4107QWP ABC-2 type transporter AB180_25555 ENOG4105CJ1 ABC, transporter AB180_25560 ENOG4105D0S secretion protein (HlyD AB180_25565 ENOG4107MVR Transcriptional regulator AB180_25570 ENOG4105C1J atp-dependent rna helicase AB180_25575 ENOG4105FDP GntR family transcriptional regulator AB180_25580 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase AB180_25585 ENOG4107QPK )-transporter AB180_25590 ENOG4105DVT helicase AB180_25595 ENOG4108MTB glycosyl transferase family AB180_25600 ENOG4105DG4 malate L-lactate dehydrogenase AB180_25605 ENOG4105VR4 UPF0379 protein ybiJ AB180_25610 ENOG4105KSC Transcriptional regulator, TraR DksA family AB180_25620 ENOG4108IU3 tonb-dependent siderophore receptor AB180_25625 ENOG4105ZY9 UPF0379 protein ybiM AB180_25630 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) AB180_25635 ENOG4105D8X mechanosensitive ion channel AB180_25640 ENOG4105CDA abc transporter atp-binding protein AB180_25645 ENOG4105E5Q amino acid AbC transporter AB180_25650 ENOG4107R0W ABC transporter AB180_25655 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction AB180_25665 ENOG4108T1M outer membrane protein x AB180_25670 ENOG4108I6E Sulfatase AB180_25680 ENOG4105KST dependent repressor AB180_25685 ENOG4105F4P )-transporter AB180_25690 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AB180_25695 ENOG4105C5H ABC transporter AB180_25700 ENOG41072TH Protein of unknown function (DUF1479) AB180_25705 ENOG4108HCJ Hydrolase AB180_25710 ENOG4105C6N Formate acetyltransferase AB180_25715 ENOG4105F1A Pyruvate formate-lyase AB180_25720 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AB180_25725 ENOG4105D06 uba thif-type nad fad binding protein AB180_25730 ENOG4105CVM Molybdenum cofactor synthesis domain protein AB180_25740 ENOG4105D44 asparaginase AB180_25745 ENOG4108JQ6 ABC transporter AB180_25750 ENOG4105DEF Extracellular solute-binding protein, family 5 AB180_25755 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AB180_25760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AB180_25845 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway AB180_25850 ENOG4105D8V Glucose sorbosone dehydrogenase AB180_25855 ENOG4108TGY Glutathione S-transferase AB180_25860 ENOG4105DZ1 carboxypeptidase AB180_25865 ENOG4107FB0 transcriptional regulator DeoR family AB180_25870 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AB180_25875 ENOG4107QF7 multi-drug AB180_25885 ENOG4108HCJ Hydrolase AB180_25890 ENOG4106UW1 Major Facilitator superfamily AB180_25895 ENOG4108RFG Tetr family transcriptional regulator AB180_25900 ENOG4105C5Q Transcriptional regulator AB180_25925 ENOG4105D0C transport protein AB180_25930 ENOG4105GWF inner membrane protein YbjM AB180_25935 ENOG41090BQ Glutaredoxin AB180_25940 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress AB180_25945 ENOG4108DBC nitroreductase AB180_25950 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) AB180_25955 ENOG4108RMJ sensory transduction regulator AB180_25960 ENOG4107RUE extracellular solute-binding protein family 1 AB180_25965 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AB180_25970 ENOG4105F38 ABC transporter, permease AB180_25975 ENOG4105D38 putrescine abc transporter AB180_25980 ENOG4105RBQ inner membrane protein ybjO AB180_25995 ENOG4105CHJ isochorismatase hydrolase AB180_26000 ENOG4105EUB pirin domain protein AB180_26005 ENOG4105HEI LysR family (Transcriptional regulator AB180_26010 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AB180_26015 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) AB180_26020 ENOG4108JJ8 (ABC) transporter AB180_26025 ENOG4108JJ9 ABC, transporter AB180_26030 ENOG4105C3M thioredoxin reductase AB180_26035 ENOG4105EW9 transcriptional regulator AsnC family AB180_26040 ENOG4105CNU cell division protein FtsK AB180_26050 ENOG4105D1H recombination factor protein RarA AB180_26055 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AB180_26060 ENOG4107QY8 reductase AB180_26065 ENOG4105QAX Iron-sulfur AB180_26070 ENOG4107KGK dmso reductase anchor subunit AB180_26075 ENOG4105CHJ isochorismatase hydrolase AB180_26080 ENOG4108ISG Major Facilitator AB180_26085 ENOG4105E5D amino acid AB180_26090 ENOG4105F1A Pyruvate formate-lyase AB180_26095 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AB180_26130 ENOG4105VZ1 Replication Protein AB180_26145 ENOG4105ED4 portal protein AB180_26270 ENOG4105C6N Formate acetyltransferase AB180_26275 ENOG4105TMB Formate nitrite transporter AB180_26280 ENOG4105DDY UPF0142 protein ycaO AB180_26285 ENOG4107VMU Membrane AB180_26290 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AB180_26295 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AB180_26300 ENOG4108K0D peptidase, M48 AB180_26305 ENOG4105CAT Cytidine monophosphate kinase AB180_26310 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AB180_26315 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) AB180_26320 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AB180_26330 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AB180_26335 ENOG4105T0Z Conserved Protein AB180_26345 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) AB180_26350 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups AB180_26355 ENOG4107S90 membrAne AB180_26360 ENOG4106371 Methyltransferase AB180_26370 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AB180_26375 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) AB180_26380 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AB180_26385 ENOG4105EAQ (twin-arginine translocation) pathway signal AB180_26390 ENOG4105C5X domain protein AB180_26395 ENOG4105CGF Aromatic amino acid aminotransferase AB180_26410 ENOG4107RH7 Nicotinate phosphoribosyltransferase AB180_26415 ENOG4105CD8 aminopeptidase N AB180_26420 ENOG4105E2Y ABC, transporter AB180_26425 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AB180_26430 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AB180_26435 ENOG4105GVF (ABC) transporter AB180_26440 ENOG4108UZX fmn reductase AB180_26450 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AB180_26455 ENOG4105QVC MOSC domain-containing protein AB180_26460 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)