locus-tag class description GPJ68_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GPJ68_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GPJ68_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPJ68_00025 ENOG410667J hydrolase GPJ68_00030 ENOG4107WAP fad NAD(P)-binding domain GPJ68_00035 ENOG4105D99 atp gtp-binding protein GPJ68_00040 ENOG4105R2A (LipO)protein GPJ68_00045 ENOG4108ZNX Heat shock protein GPJ68_00050 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) GPJ68_00065 ENOG4105FDP GntR family transcriptional regulator GPJ68_00070 ENOG4105CI1 PTS System GPJ68_00075 ENOG4105F8D glycoside hydrolase family 4 GPJ68_00080 ENOG4108AHD Transcriptional regulator GPJ68_00085 ENOG4107RUZ Sss sodium solute transporter superfamily GPJ68_00090 ENOG4105CBG Sulfatase GPJ68_00095 ENOG4105VG5 Membrane GPJ68_00100 ENOG4105JP4 Inner membrane protein yidG GPJ68_00105 ENOG4105C4X radical SAM domain protein GPJ68_00110 ENOG4105BZC d-serine deaminase GPJ68_00120 ENOG4105W8I Transcriptional regulator GPJ68_00130 ENOG4105E5M Multidrug resistance protein D GPJ68_00150 ENOG4105C7K acetolactate synthase GPJ68_00155 ENOG4105M71 acetolactate synthase 1 regulatory subunit GPJ68_00160 ENOG4107FB0 transcriptional regulator DeoR family GPJ68_00170 ENOG4105EDR glucose galactose transporter GPJ68_00180 ENOG4108KX4 response regulator GPJ68_00185 ENOG4105BZU Histidine kinase GPJ68_00190 ENOG4105CXY transporter GPJ68_00195 ENOG4105CXY transporter GPJ68_00200 ENOG4108SAJ Protein of unknown function (DUF1198) GPJ68_00210 ENOG4105CS2 ec 3.2.1.21 GPJ68_00225 ENOG4105D01 (LipO)protein GPJ68_00230 ENOG4108UZ3 Transporter GPJ68_00240 ENOG4105CIS alcohol dehydrogenase GPJ68_00245 ENOG4105EJC lysr family transcriptional regulator GPJ68_00250 ENOG4106PHM regulatory protein GPJ68_00255 ENOG4108SQA Fimbrial GPJ68_00270 ENOG4105F2I Transposase GPJ68_00285 ENOG41086KC Transcriptional regulator GPJ68_00305 ENOG4105ISV protein with bipartite regulator domain GPJ68_00340 ENOG4105CT4 transporter GPJ68_00345 ENOG4105CJQ hydrolase, family 31 GPJ68_00350 ENOG4105ETD TRANSCRIPTIONal GPJ68_00355 ENOG4105DM4 PTS System GPJ68_00360 ENOG4108YRF PTS System GPJ68_00365 ENOG4105DM4 PTS System GPJ68_00370 ENOG4105D2N Aldolase GPJ68_00375 ENOG4105D2N Aldolase GPJ68_00385 ENOG4105JV1 AsmA family GPJ68_00390 ENOG4105C2W permease GPJ68_00395 ENOG4105D6U Sodium Glutamate Symporter GPJ68_00400 ENOG4105CB5 ATP-dependent DNA helicase recG GPJ68_00405 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase GPJ68_00410 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPJ68_00425 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) GPJ68_00430 ENOG4105EN6 Membrane GPJ68_00440 ENOG4105DSJ YicC domain protein GPJ68_00445 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GPJ68_00460 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GPJ68_00465 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GPJ68_00470 ENOG4105W5Q DNA repair protein (RadC GPJ68_00480 ENOG4105W0E 50S ribosomal protein L33 GPJ68_00485 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GPJ68_00490 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GPJ68_00495 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase GPJ68_00500 ENOG4105DKP glycosyl transferase, family 9 GPJ68_00505 ENOG4107RJ7 Glycosyl transferase (Group 1 GPJ68_00510 ENOG4107543 (lipo)polysaccharide GPJ68_00515 ENOG4106AH0 Glycosyl Transferase GPJ68_00520 ENOG4105X1N Glycosyl transferase family 8 GPJ68_00525 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase GPJ68_00530 ENOG4108FRV O-antigen ligase GPJ68_00535 ENOG4105D16 lipopolysaccharide heptosyltransferase i GPJ68_00540 ENOG4105XA0 heptosyltransferase ii GPJ68_00550 ENOG4108SEH involved in lipopolysaccharide biosynthesis GPJ68_00555 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPJ68_00560 ENOG4105CPQ Dehydrogenase GPJ68_00570 ENOG4105K64 Glycosyl transferase, family 2 GPJ68_00575 ENOG4105PXI polysaccharide deacetylase GPJ68_00580 ENOG41063SB peptidase GPJ68_00590 ENOG4107YZP Rhodanese domain protein GPJ68_00595 ENOG4105VW4 glutaredoxin 3 GPJ68_00600 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) GPJ68_00605 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GPJ68_00610 ENOG4105D7W serine acetyltransferase GPJ68_00615 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GPJ68_00620 ENOG4105D2S major facilitator superfamily GPJ68_00625 ENOG4105DMF Dehydrogenase GPJ68_00630 ENOG41073TP transcriptional regulator GPJ68_00635 ENOG4105DAA L-lactate GPJ68_00640 ENOG4108YYI Protein of unknown function (DUF2810) GPJ68_00650 ENOG4105E61 Mannitol repressor protein GPJ68_00660 ENOG4105CTS PTS system mannitol-specific GPJ68_00665 ENOG4105FP6 Protein of unknown function (DUF3302) GPJ68_00670 ENOG4105EFX secretion protein, HlyD family GPJ68_00675 ENOG4108U78 Glutathione S-transferase GPJ68_00685 ENOG4105EM7 Selenocysteine-specific translation elongation factor GPJ68_00690 ENOG4105C0A alcohol dehydrogenase GPJ68_00695 ENOG4105C26 Dehydrogenase GPJ68_00700 ENOG4105KK7 inner membrane protein YiaW GPJ68_00705 ENOG4105EFX secretion protein, HlyD family GPJ68_00710 ENOG4108Q2M Transcriptional regulator GPJ68_00715 ENOG4105GNX MltA-interacting MipA family protein GPJ68_00720 ENOG4108XIB electron transport protein ysaA GPJ68_00725 ENOG4105JKW Valine--pyruvate aminotransferase GPJ68_00730 ENOG4107T9C Alpha amylase catalytic region GPJ68_00735 ENOG4108UR8 BAX protein GPJ68_00740 ENOG4105T16 Transcriptional regulator (AraC family) GPJ68_00755 ENOG4105DFW ABC transporter GPJ68_00765 ENOG4105CMG Carbohydrate kinase GPJ68_00770 ENOG410688U Inner membrane protein yiaB GPJ68_00775 ENOG4108Z12 YiaAB two helix domain-containing protein GPJ68_00780 ENOG4105MEV Acyl-transferase GPJ68_00795 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GPJ68_00810 ENOG4105MVF Transcriptional regulator GPJ68_00815 ENOG4106JH6 (LipO)protein GPJ68_00820 ENOG4105C5I Dehydrogenase GPJ68_00825 ENOG4105JHE Major Facilitator Superfamily GPJ68_00830 ENOG4105D7K pfkb domain protein GPJ68_00840 ENOG4108M60 Transcriptional regulator GPJ68_00845 ENOG4108ZG0 Ompa motb domain protein GPJ68_00850 ENOG4107QY8 reductase GPJ68_00855 ENOG4105HNP -acetyltransferase GPJ68_00860 ENOG4108R3E Dna-3-methyladenine glycosylase i GPJ68_00865 ENOG4105EAX Putative lipase GPJ68_00875 ENOG4105FCD Major Facilitator GPJ68_00880 ENOG4105DIJ Phosphoethanolamine transferase GPJ68_00900 ENOG4105DEF Extracellular solute-binding protein, family 5 GPJ68_00905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPJ68_00910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPJ68_00915 ENOG4105C3U ABC transporter GPJ68_00920 ENOG4108JQ7 (ABC) transporter GPJ68_00925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPJ68_00930 ENOG4105C44 Serine transporter GPJ68_00940 ENOG4105C28 cystathionine GPJ68_00950 ENOG4105BZU Histidine kinase GPJ68_00955 ENOG4105CK2 sodium dicarboxylate symporter GPJ68_00960 ENOG4105CS0 peptidase GPJ68_00965 ENOG4107SS6 2-dehydro-3-deoxygluconokinase GPJ68_00970 ENOG4105CMB EAL domain-containing protein GPJ68_00975 ENOG41066T0 asmA family GPJ68_00980 ENOG4105CSH Transporter GPJ68_00985 ENOG4107H3J ribonuclease GPJ68_00990 ENOG4105CBN LysR family transcriptional regulator GPJ68_01000 ENOG4106S2D Transcriptional regulator GPJ68_01010 ENOG41068WN GPJ68_01025 ENOG4105CA0 peroxidase GPJ68_01035 ENOG4105DC8 reductase GPJ68_01045 ENOG4105DGW oligopeptidase A GPJ68_01055 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GPJ68_01060 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase GPJ68_01065 ENOG4107EDW L-fucose operon activator GPJ68_01075 ENOG4105CTS PTS system mannitol-specific GPJ68_01090 ENOG4105CHR reductase GPJ68_01100 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GPJ68_01105 ENOG4105DUX Transporter GPJ68_01115 ENOG4108V6B universal stress protein B GPJ68_01120 ENOG4105CJ3 phosphate transporter GPJ68_01125 ENOG4105CBX hi0933 family GPJ68_01205 ENOG4105CJW magnesium transporter GPJ68_01210 ENOG4105D0S secretion protein (HlyD GPJ68_01215 ENOG4105CJ1 ABC, transporter GPJ68_01220 ENOG4105CMI transporter GPJ68_01230 ENOG4105CMI transporter GPJ68_01235 ENOG4105MRR Transcriptional regulator (By similarity) GPJ68_01245 ENOG4105PY6 Phenolic acid decarboxylase GPJ68_01250 ENOG4107YAK holo-(acyl carrier protein) synthase 2 GPJ68_01255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPJ68_01260 ENOG4105C2D reductase GPJ68_01295 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GPJ68_01345 ENOG4105DSF transport protein GPJ68_01350 ENOG4105F9N Major Facilitator Superfamily GPJ68_01355 ENOG4108W1V Lipoprotein GPJ68_01360 ENOG4105EX9 Membrane GPJ68_01375 ENOG4107FS9 Membrane GPJ68_01385 ENOG4105MG3 Membrane GPJ68_01390 ENOG4106H78 methyltransferase GPJ68_01395 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GPJ68_01400 ENOG4105CAK Cell division ATP-binding protein ftsE GPJ68_01405 ENOG4105CRP Part of the ABC transporter FtsEX involved in GPJ68_01415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GPJ68_01445 ENOG4105CP9 extracellular ligand-binding receptor GPJ68_01450 ENOG4105U59 -acetyltransferase GPJ68_01455 ENOG4105CP9 extracellular ligand-binding receptor GPJ68_01460 ENOG4105C32 Amino acid ABC transporter (Permease) GPJ68_01465 ENOG4105CF8 branched-chain amino acid ABC transporter, permease GPJ68_01470 ENOG4105C0Z ABC transporter GPJ68_01475 ENOG4108IV0 ABC, transporter GPJ68_01485 ENOG4105BZ7 extracellular solute-binding protein family 1 GPJ68_01490 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component GPJ68_01505 ENOG4107T6V glycerophosphoryl diester phosphodiesterase GPJ68_01515 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GPJ68_01520 ENOG41080QX K07048 phosphotriesterase-related protein GPJ68_01535 ENOG4108RVA ribokinase GPJ68_01545 ENOG4105WCN acetyltransferase GPJ68_01550 ENOG4105D9R oxidoreductase GPJ68_01555 ENOG4105C2I pirin domain protein GPJ68_01560 ENOG4105DIQ Transcriptional regulator GPJ68_01565 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GPJ68_01570 ENOG4105C6Z Gluconate GPJ68_01580 ENOG41076UM multiple antibiotic resistance (MarC)-related protein GPJ68_01585 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPJ68_01595 ENOG4108IUM Glycogen debranching enzyme GPJ68_01605 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GPJ68_01610 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GPJ68_01615 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GPJ68_01620 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) GPJ68_01625 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) GPJ68_01630 ENOG4105E98 transcriptional regulator DeoR family GPJ68_01635 ENOG41061ZR Transcriptional regulator GPJ68_01640 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) GPJ68_01645 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) GPJ68_01650 ENOG4105C6Z Gluconate GPJ68_01660 ENOG4105MJ2 Competence protein GPJ68_01670 ENOG4105DNE Transposase GPJ68_01680 ENOG4105CE1 Ferrous iron transport protein b GPJ68_01685 ENOG4105XFK Ferrous iron transport protein A GPJ68_01690 ENOG4105BZM domain protein GPJ68_01695 ENOG4108RRZ Transcription elongation factor GreB GPJ68_01705 ENOG4105E0F Histidine kinase GPJ68_01710 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GPJ68_01715 ENOG4108MAJ Membrane GPJ68_01725 ENOG4105VEJ Heat shock protein GPJ68_01730 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 GPJ68_01735 ENOG4105DQY intracellular growth attenuator GPJ68_01740 ENOG4107RK2 ADP-ribose diphosphatase NudE GPJ68_01745 ENOG4108JQC penicillin-binding protein 1A GPJ68_01750 ENOG4108U1Q Pilus assembly protein GPJ68_01755 ENOG41065NF Fimbrial assembly family protein GPJ68_01765 ENOG4105ITY Required for the use of extracellular DNA as a nutrient GPJ68_01770 ENOG4105E4G Type IV pilus GPJ68_01775 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GPJ68_01780 ENOG4105D49 3-dehydroquinate synthase GPJ68_01785 ENOG4105EGB membrane protein DamX GPJ68_01790 ENOG4105DFE Dna adenine methylase GPJ68_01795 ENOG4105DJV ribulose-phosphate 3-epimerase GPJ68_01800 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GPJ68_01805 ENOG4105C31 Tryptophanyl-tRNA synthetase GPJ68_01815 ENOG4105VYH GPJ68_01825 ENOG4107V9H nitrite transporter GPJ68_01830 ENOG4105WZK nitrite reductase NADPH small subunit GPJ68_01835 ENOG4107QZF nitrite reductase NADPH large subunit GPJ68_01845 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPJ68_01855 ENOG4105MZU cell filamentation protein GPJ68_01860 ENOG4105DDQ anthranilate synthase GPJ68_01865 ENOG4105C8Y Acetylornithine aminotransferase GPJ68_01870 ENOG410613R integral membrane protein, YccS YhfK family GPJ68_01875 ENOG4107RYR Transcriptional regulator, Crp Fnr family GPJ68_01880 ENOG4108UKZ OsmC family GPJ68_01885 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) GPJ68_01895 ENOG4105DNZ Alpha Beta Hydrolase GPJ68_01900 ENOG4105C5H ABC transporter GPJ68_01905 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GPJ68_01910 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPJ68_01915 ENOG4105VKU nucleicacid-binding protein GPJ68_01920 ENOG4108YZY peptidylprolyl cis-trans isomerase GPJ68_01925 ENOG4105VRX Protein slyX homolog GPJ68_01930 ENOG4108V1T peptidylprolyl cis-trans isomerase GPJ68_01935 ENOG4105WWK YheO domain protein GPJ68_01940 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) GPJ68_01945 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPJ68_01950 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) GPJ68_01965 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GPJ68_01970 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GPJ68_01980 ENOG4105W53 bacterioferritin-associated ferredoxin GPJ68_01985 ENOG4108UQY Iron-storage protein GPJ68_02000 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) GPJ68_02005 ENOG4105R04 type II secretion system protein K GPJ68_02020 ENOG41069X0 general secretion pathway protein h GPJ68_02025 ENOG4108VAU general secretion pathway protein G GPJ68_02035 ENOG4105F9F transposase GPJ68_02045 ENOG4107QHF type ii secretion system protein e GPJ68_02050 ENOG4105GVR general secretion pathway protein D GPJ68_02075 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GPJ68_02080 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GPJ68_02095 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GPJ68_02100 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GPJ68_02115 ENOG41083MP 50s ribosomal protein l29 GPJ68_02120 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GPJ68_02140 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GPJ68_02150 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GPJ68_02160 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GPJ68_02165 ENOG4105VPB 50S ribosomal protein L30 GPJ68_02170 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GPJ68_02175 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GPJ68_02180 ENOG41067V7 50S ribosomal protein L36 GPJ68_02190 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GPJ68_02210 ENOG4105VTS DnaJ-like, subfamily C GPJ68_02215 ENOG4105W1Y Transcriptional regulator GPJ68_02220 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system GPJ68_02225 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GPJ68_02230 ENOG4105C1A potassium transporter peripheral membrane GPJ68_02245 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GPJ68_02250 ENOG4105C79 DNA protecting protein DprA GPJ68_02260 ENOG4108WI1 Dna topoisomerase GPJ68_02265 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPJ68_02270 ENOG4105E2X shikimate dehydrogenase GPJ68_02275 ENOG4105SG3 Protein of unknown function (DUF1488) GPJ68_02280 ENOG4108Z0R Transferase GPJ68_02350 ENOG4108SIC Transcriptional regulator GPJ68_02355 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) GPJ68_02365 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPJ68_02370 ENOG4108IJ0 Aspartate ammonia-lyase GPJ68_02375 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 GPJ68_02380 ENOG4105DVH amino acid GPJ68_02390 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GPJ68_02395 ENOG4108ZVF (LipO)protein GPJ68_02400 ENOG4105MTB Uncharacterized protein YjeJ GPJ68_02405 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GPJ68_02450 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) GPJ68_02460 ENOG4105E33 succinate dehydrogenase GPJ68_02465 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GPJ68_02470 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) GPJ68_02475 ENOG4107SC7 Inner membrane transporter yjeM GPJ68_02485 ENOG4106CG8 Inner membrane protein YjeO GPJ68_02490 ENOG4105EGS Mechanosensitive ion channel GPJ68_02495 ENOG4105DJ4 phosphatidylserine decarboxylase GPJ68_02525 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GPJ68_02530 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GPJ68_02535 ENOG4105K8N protein family UPF0079, ATPase GPJ68_02540 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GPJ68_02545 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GPJ68_02555 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GPJ68_02560 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GPJ68_02565 ENOG4107QJR hflk protein GPJ68_02570 ENOG4105EPW hflc protein GPJ68_02580 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GPJ68_02590 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GPJ68_02595 ENOG4105C2N RNA methyltransferase TrmH family group 3 GPJ68_02600 ENOG4105CSU acyl-Coa dehydrogenase GPJ68_02605 ENOG4105S17 UPF0379 protein yjfN GPJ68_02610 ENOG4105WSB biofilm stress and motility protein A GPJ68_02615 ENOG4108MXZ Esterase GPJ68_02620 ENOG4105DW5 Transcriptional regulator GPJ68_02645 ENOG4105H6Q decarboxylase GPJ68_02660 ENOG4105KIT UPF0379 protein yjfY GPJ68_02665 ENOG4105EJ9 Membrane GPJ68_02675 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) GPJ68_02680 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GPJ68_02685 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GPJ68_02695 ENOG4105FHY Opacity-associated protein A GPJ68_02700 ENOG4108V1T peptidylprolyl cis-trans isomerase GPJ68_02705 ENOG4105C85 amino acid GPJ68_02710 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GPJ68_02715 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_02720 ENOG4105DXC membrane GPJ68_02730 ENOG4105ECR NmrA family GPJ68_02735 ENOG4105KVH Transcriptional regulator GPJ68_02740 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic GPJ68_02745 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase GPJ68_02750 ENOG4108UUE Transcriptional regulator GPJ68_02755 ENOG41061GZ Protein of unknown function (DUF1107) GPJ68_02760 ENOG4105C37 (CBS) domain GPJ68_02770 ENOG4105CFU surface antigen GPJ68_02775 ENOG4105MA0 exported protein GPJ68_02780 ENOG4108ZHD aig2 family GPJ68_02785 ENOG4105D05 Receptor GPJ68_02790 ENOG4108NS2 receptor GPJ68_02795 ENOG4105F0N pyrophosphate phospho-hydrolase GPJ68_02800 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator GPJ68_02805 ENOG4105C2J ABC transporter GPJ68_02810 ENOG4107R9N ABC transporter GPJ68_02815 ENOG41062B0 ABC transporter, permease GPJ68_02820 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_02825 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 GPJ68_02830 ENOG4105DFU Cell wall formation (By similarity) GPJ68_02835 ENOG4105C2X Arabinose 5-phosphate isomerase GPJ68_02840 ENOG4105F8D glycoside hydrolase family 4 GPJ68_02845 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GPJ68_02850 ENOG4105CK1 PTS System GPJ68_02855 ENOG4105N42 UPF0307 protein GPJ68_02860 ENOG4105CMS peptidase U62, modulator of DNA gyrase GPJ68_02865 ENOG4108XVM Cytochrome b(562) GPJ68_02895 ENOG41069H0 dihydroorotase EC 3.5.2.3 GPJ68_02910 ENOG4105EMD TRANSCRIPTIONal GPJ68_02975 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPJ68_02995 ENOG4105DQ4 alcohol dehydrogenase GPJ68_03000 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family GPJ68_03005 ENOG4105CPQ Dehydrogenase GPJ68_03010 ENOG4105CHR reductase GPJ68_03015 ENOG4105C6Z Gluconate GPJ68_03020 ENOG4105K2J Transcriptional regulator GPJ68_03025 ENOG4105D7A ATP-binding protein GPJ68_03030 ENOG4108K5H permease YjgP YjgQ family protein GPJ68_03035 ENOG4108M8S permease YjgP YjgQ family protein GPJ68_03040 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPJ68_03045 ENOG4105MYG DNA polymerase iii, chi subunit GPJ68_03050 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GPJ68_03055 ENOG4108M3P Membrane GPJ68_03060 ENOG4108MJ3 acetyltransferase GPJ68_03070 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase GPJ68_03075 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) GPJ68_03085 ENOG4105XEP YhcH YjgK YiaL family protein GPJ68_03090 ENOG4105CEU Arginine dihydrolase GPJ68_03095 ENOG4105C5B carbamate kinase GPJ68_03100 ENOG4105DBV ornithine carbamoyltransferase GPJ68_03105 ENOG4105CSX c4-dicarboxylate anaerobic carrier GPJ68_03110 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GPJ68_03120 ENOG4107C93 pyrBI operon leader peptide GPJ68_03130 ENOG4105CXT aspartate transcarbamylase GPJ68_03135 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) GPJ68_03140 ENOG4105KME endoribonuclease L-psp GPJ68_03145 ENOG4107EF2 surface-exposed virulence protein GPJ68_03155 ENOG4105D4X repressor GPJ68_03160 ENOG4105C5Y PTS System GPJ68_03165 ENOG4105CG3 alpha amylase, catalytic region GPJ68_03170 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GPJ68_03175 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) GPJ68_03185 ENOG4105CS6 Rhs element vgr protein GPJ68_03190 ENOG4105K4U addiction module toxin, RelE StbE family GPJ68_03225 ENOG4105D6U Sodium Glutamate Symporter GPJ68_03240 ENOG4108ZHR arsR family transcriptional regulator GPJ68_03385 ENOG4108YXQ IS66 Orf2 family protein GPJ68_03390 ENOG4105E5H Transposase GPJ68_03445 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GPJ68_03450 ENOG4107QR9 Iron-sulfur cluster binding protein GPJ68_03455 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GPJ68_03470 ENOG4105DEI Mannitol dehydrogenase GPJ68_03475 ENOG4105C6F GntR Family Transcriptional Regulator GPJ68_03485 ENOG4105FCK Membrane GPJ68_03495 ENOG4105CBP Major Facilitator GPJ68_03500 ENOG4106BRA Membrane GPJ68_03505 ENOG410642W LysR family Transcriptional regulator GPJ68_03510 ENOG4105CK2 sodium dicarboxylate symporter GPJ68_03515 ENOG4105C28 cystathionine GPJ68_03520 ENOG41083G8 Multidrug resistance protein MdtM GPJ68_03530 ENOG4106AXJ AraC family transcriptional regulator GPJ68_03535 ENOG4105DNE Transposase GPJ68_03540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPJ68_03545 ENOG4106DIZ Domain of unknown function (DUF1127) GPJ68_03595 ENOG4105CKI cobalamin synthesis protein GPJ68_03600 ENOG4105VCD cytoplasmic protein GPJ68_03605 ENOG4105D22 carbon starvation protein GPJ68_03615 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_03620 ENOG4105XYF acetyltransferase GPJ68_03625 ENOG4108I5G Major Facilitator superfamily GPJ68_03630 ENOG410617M Transcriptional regulator GPJ68_03635 ENOG4105CPQ Dehydrogenase GPJ68_03650 ENOG4105RI1 glycoprotein receptor GPJ68_03655 ENOG4106CVF DNA replication protein GPJ68_03660 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) GPJ68_03665 ENOG4107XM3 UPF0442 protein GPJ68_03670 ENOG4105DWK Membrane GPJ68_03675 ENOG4108N8T regulatoR GPJ68_03680 ENOG4108T94 DNA-binding transcriptional activator BglJ GPJ68_03685 ENOG4108UIN ybak prolyl-trna synthetase associated region GPJ68_03690 ENOG4105CK1 PTS System GPJ68_03695 ENOG4108819 ferric iron reductase GPJ68_03700 ENOG4105BZU Histidine kinase GPJ68_03705 ENOG4105YBH Protein of unknown function (DUF1435) GPJ68_03730 ENOG4108WPU DNA polymerase III subunit psi GPJ68_03735 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GPJ68_03740 ENOG4105PAD Hydrolase GPJ68_03745 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) GPJ68_03750 ENOG4105K3G Periplasmic Protein GPJ68_03760 ENOG4108NRW Phospholipase, patatin family GPJ68_03765 ENOG4105EYA deoxyribonuclease GPJ68_03770 ENOG41076CZ activating enzyme GPJ68_03775 ENOG4105G0K glycine radical enzyme YjjI family GPJ68_03805 ENOG41062Z9 Membrane GPJ68_03810 ENOG4105EAC phosphoserine phosphatase GPJ68_03815 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GPJ68_03820 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase GPJ68_03825 ENOG4105C5H ABC transporter GPJ68_03830 ENOG4107SC1 transglycosylase GPJ68_03835 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) GPJ68_03840 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GPJ68_03845 ENOG4105CVJ phosphoglycerate mutase GPJ68_03850 ENOG4105UEI Transcriptional Regulator AraC Family GPJ68_03855 ENOG4108RH0 Crea protein GPJ68_03860 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPJ68_03865 ENOG4105EB3 Histidine kinase GPJ68_03870 ENOG4105CT7 inner membrane cred family protein GPJ68_03875 ENOG41065U4 response regulator GPJ68_03880 ENOG410759A GPJ68_03885 ENOG4106FVC RNA methyltransferase GPJ68_03895 ENOG4105CFH Aspartokinase GPJ68_03905 ENOG4105D98 threonine synthase GPJ68_03910 ENOG4105D1Q UPF0246 protein GPJ68_03915 ENOG4105BZG amino acid carrier protein GPJ68_03920 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPJ68_03925 ENOG4108RIR Molybdenum cofactor biosynthesis protein GPJ68_03930 ENOG4105CSH Transporter GPJ68_03935 ENOG4106HK8 GPR1 FUN34 yaaH family protein GPJ68_03940 ENOG4105CFG Acts as a chaperone (By similarity) GPJ68_03975 ENOG41063Z6 transcriptional regulator, lysR family GPJ68_04005 ENOG4105DTN riboflavin biosynthesis protein ribF GPJ68_04010 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GPJ68_04020 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase GPJ68_04025 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GPJ68_04030 ENOG4105DU0 nucleoside hydrolase GPJ68_04035 ENOG4108Y83 glucose-6-phosphate isomerase GPJ68_04045 ENOG4105F3R pts system mannose fructose sorbose family iid GPJ68_04050 ENOG4105ETZ PTS System GPJ68_04055 ENOG4105DAS pts system GPJ68_04070 ENOG4107P2S Transcriptional regulator GPJ68_04075 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GPJ68_04080 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GPJ68_04085 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GPJ68_04090 ENOG4108XNW Transcriptional activatory protein CaiF GPJ68_04135 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPJ68_04140 ENOG4105WQV ferredoxin-like protein GPJ68_04145 ENOG4105C54 Major Facilitator superfamily GPJ68_04150 ENOG4105M5B (LipO)protein GPJ68_04160 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPJ68_04170 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GPJ68_04175 ENOG4105NWN ApaG protein GPJ68_04180 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GPJ68_04185 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) GPJ68_04195 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) GPJ68_04205 ENOG4105D3G Pseudouridine synthase GPJ68_04210 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) GPJ68_04215 ENOG4105CQ2 DNA polymerase GPJ68_04225 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GPJ68_04245 ENOG4108KF1 Membrane GPJ68_04255 ENOG4106SMU thiamine transporter membrane protein GPJ68_04275 ENOG4105S8Q sugar efflux transporter GPJ68_04280 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPJ68_04285 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GPJ68_04305 ENOG41064T2 transcriptional regulator, lysR family GPJ68_04310 ENOG4105C7K acetolactate synthase GPJ68_04315 ENOG4108ZP8 Acetolactate synthase small subunit GPJ68_04320 ENOG4107B7Y DNA-binding transcriptional regulator FruR GPJ68_04325 ENOG4108V6E Cell division protein mraZ GPJ68_04335 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPJ68_04340 ENOG4105CJN penicillin-binding protein GPJ68_04345 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GPJ68_04350 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) GPJ68_04355 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GPJ68_04360 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GPJ68_04365 ENOG4105CNI cell division protein FtsW GPJ68_04370 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GPJ68_04380 ENOG4105CPF Cell wall formation (By similarity) GPJ68_04385 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) GPJ68_04390 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GPJ68_04395 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GPJ68_04405 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) GPJ68_04415 ENOG4105M6F mutator MutT protein GPJ68_04420 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) GPJ68_04425 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) GPJ68_04430 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GPJ68_04435 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPJ68_04440 ENOG4105D7Q type ii secretion system GPJ68_04445 ENOG4107QHF type ii secretion system protein e GPJ68_04450 ENOG4108ZUW Major pilin subunit GPJ68_04455 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GPJ68_04465 ENOG4106A72 regulatory protein AmpE GPJ68_04470 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) GPJ68_04475 ENOG4105CT4 transporter GPJ68_04480 ENOG4105C85 amino acid GPJ68_04490 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) GPJ68_04495 ENOG4107QSN dihydrolipoamide acetyltransferase GPJ68_04500 ENOG4107QN2 dihydrolipoyl dehydrogenase GPJ68_04515 ENOG4108NST exported protein GPJ68_04520 ENOG4107QIJ Aconitate hydratase 2 GPJ68_04545 ENOG4108ZRK uncharacterized protein yacC GPJ68_04550 ENOG4105E3B Multicopper oxidase GPJ68_04565 ENOG4108UGV hypoxanthine phosphoribosyltransferase GPJ68_04570 ENOG41077A9 carbonic anhydrase GPJ68_04575 ENOG4105DA5 (ABC) transporter GPJ68_04580 ENOG4105E3A (ABC) transporter GPJ68_04585 ENOG4108YTN IIa component GPJ68_04590 ENOG4107BJW polysaccharide deacetylase GPJ68_04610 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GPJ68_04615 ENOG4105DJ0 Poly(A) Polymerase GPJ68_04620 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) GPJ68_04625 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters GPJ68_04630 ENOG4105PW4 Sugar fermentation stimulation protein homolog GPJ68_04635 ENOG4107XID 2'-5' rna ligase GPJ68_04640 ENOG4105CQ7 ATP-dependent helicase GPJ68_04645 ENOG4105BZ4 penicillin-binding protein GPJ68_04650 ENOG4105E0K tonB-dependent siderophore receptor GPJ68_04655 ENOG4105E0A ABC, transporter GPJ68_04660 ENOG4105J76 Periplasmic binding protein GPJ68_04665 ENOG4105S6R Iron-hydroxamate transporter permease subunit GPJ68_04675 ENOG4105CMQ Chloride channel GPJ68_04680 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GPJ68_04685 ENOG4105EN6 Membrane GPJ68_04690 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GPJ68_04695 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GPJ68_04700 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein GPJ68_04705 ENOG4105C0H protease GPJ68_04710 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR GPJ68_04720 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) GPJ68_04725 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) GPJ68_04730 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GPJ68_04735 ENOG4105CE9 30S ribosomal protein S2 GPJ68_04745 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GPJ68_04750 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GPJ68_04755 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) GPJ68_04765 ENOG4105KNE Phosphatidate cytidylyltransferase GPJ68_04775 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GPJ68_04780 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) GPJ68_04785 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPJ68_04800 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) GPJ68_04805 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPJ68_04810 ENOG4105C0B DNA polymerase III (alpha subunit) GPJ68_04815 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) GPJ68_04820 ENOG4105CXN decarboxylase GPJ68_04825 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GPJ68_04830 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GPJ68_04835 ENOG4105M1T rho-binding antiterminator GPJ68_04845 ENOG4108VWS Yaeq family GPJ68_04850 ENOG4108YZN class I peptide chain release factor GPJ68_04855 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion GPJ68_04860 ENOG4108UY0 (LipO)protein GPJ68_04865 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GPJ68_04870 ENOG4108R96 Methyltransferase, YaeB family GPJ68_04875 ENOG4108R8X outer membrane lipoprotein GPJ68_04880 ENOG4105D01 (LipO)protein GPJ68_04885 ENOG4108UMI ABC transporter, permease GPJ68_04890 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GPJ68_04895 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GPJ68_04925 ENOG4105CV8 reductase GPJ68_04930 ENOG4105HEI LysR family (Transcriptional regulator GPJ68_04935 ENOG4105F27 Major Facilitator GPJ68_04945 ENOG4105F2W methyltransferase GPJ68_04950 ENOG4105E9H Lytic Murein transglycosylase GPJ68_04955 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GPJ68_04960 ENOG4105D1A Methyltransferase GPJ68_04965 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GPJ68_04970 ENOG4107RZZ dna polymerase iii epsilon subunit GPJ68_04990 ENOG4108TH4 Major fimbrial subunit GPJ68_05000 ENOG4106PG1 outer membrane usher protein GPJ68_05005 ENOG4108FZ9 Chaperone GPJ68_05015 ENOG4108MDY Fimbrial GPJ68_05030 ENOG4105CMB EAL domain-containing protein GPJ68_05040 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GPJ68_05045 ENOG4107QPN acyl-Coa dehydrogenase GPJ68_05055 ENOG4105E7A Glutamine amidotransferase GPJ68_05060 ENOG4105F7V ErfK ybiS ycfS ynhG family protein GPJ68_05065 ENOG4108YS0 lipoprotein YafL GPJ68_05085 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPJ68_05090 ENOG4105CIN aminoacyl-histidine dipeptidase GPJ68_05100 ENOG4105V1F Fermentation respiration switch protein GPJ68_05105 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) GPJ68_05115 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GPJ68_05120 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) GPJ68_05125 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPJ68_05130 ENOG4108GWT fimbrillin MatB GPJ68_05145 ENOG4106PYX Receptor GPJ68_05165 ENOG4108M8H domain protein GPJ68_05225 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPJ68_05230 ENOG4105C4M (Ubiquinol oxidase) subunit I GPJ68_05235 ENOG4105MVP hydrogenase-1 operon protein HyaF GPJ68_05240 ENOG4108VXY Hydrogenase-1 operon protein HyaE GPJ68_05245 ENOG4108USZ hydrogenase GPJ68_05250 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit GPJ68_05265 ENOG4105CJP fad dependent oxidoreductase GPJ68_05270 ENOG4105C26 Dehydrogenase GPJ68_05275 ENOG4107VRI Transcriptional regulator GPJ68_05280 ENOG4108Z86 Glutamine amidotransferase GPJ68_05285 ENOG4105CFQ glutamine synthetase GPJ68_05290 ENOG4105CUB amino acid GPJ68_05295 ENOG4107R7Y intracellular protease Pfpi family GPJ68_05300 ENOG4105DTA methyltransferase GPJ68_05310 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPJ68_05315 ENOG4105CEE C4-dicarboxylate transporter GPJ68_05330 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_05350 ENOG4105HEE Binding Domain protein GPJ68_05355 ENOG4105BZU Histidine kinase GPJ68_05360 ENOG4105E82 cytochrome subunit of dehydrogenase GPJ68_05365 ENOG4105TDT uncharacterized protein yahO GPJ68_05370 ENOG4108JU7 Transcriptional regulator GPJ68_05375 ENOG4105CR4 methylisocitrate lyase GPJ68_05380 ENOG4105BZN citrate synthase GPJ68_05385 ENOG4105DXD 2-methylcitrate dehydratase GPJ68_05390 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPJ68_05405 ENOG4105CNT hydrolase family 2 GPJ68_05410 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_05420 ENOG4105D5K Hemolysin activator protein GPJ68_05445 ENOG4105N0E Protein of unknown function (DUF2543) GPJ68_05460 ENOG4108K2P TRANSCRIPTIONal GPJ68_05495 ENOG4108SC4 )-transporter GPJ68_05500 ENOG4108IQI permease GPJ68_05505 ENOG4107QK5 Homocysteine s-methyltransferase GPJ68_05510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPJ68_05515 ENOG4107RCV ABC transporter, permease GPJ68_05520 ENOG4105C4Y ABC transporter GPJ68_05525 ENOG4105CXY transporter GPJ68_05535 ENOG4108KX4 response regulator GPJ68_05540 ENOG4106FTQ Taurine ABC transporter, periplasmic GPJ68_05545 ENOG4108ETV ABC transporter GPJ68_05550 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GPJ68_05555 ENOG4105E2B Taurine dioxygenase GPJ68_05560 ENOG4105D52 delta-aminolevulinic acid dehydratase GPJ68_05570 ENOG4108PNB DNA-binding transcriptional regulator GPJ68_05575 ENOG4107R6D beta-lactam binding protein AmpH GPJ68_05580 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 GPJ68_05585 ENOG4107QS8 (LipO)protein GPJ68_05590 ENOG4105FR5 inner membrane protein YaiY GPJ68_05595 ENOG4105UNH Membrane GPJ68_05600 ENOG4105CPF Cell wall formation (By similarity) GPJ68_05620 ENOG4105G6Z alkaline phosphatase GPJ68_05625 ENOG4105VIF phosphate starvation-inducible protein GPJ68_05630 ENOG4105BZU Histidine kinase GPJ68_05635 ENOG4105II7 pyrroline-5-carboxylate reductase GPJ68_05640 ENOG4108UPT UPF0178 protein GPJ68_05650 ENOG4105SS3 GPJ68_05660 ENOG4105NBK UPF0345 protein GPJ68_05670 ENOG4105DKQ ROK family GPJ68_05675 ENOG4105F27 Major Facilitator GPJ68_05680 ENOG4105EYH Exonuclease GPJ68_05685 ENOG4107RH8 nuclease SbcCD subunit D GPJ68_05695 ENOG4105BZU Histidine kinase GPJ68_05700 ENOG4105CWM branched-chain amino acid transport system II carrier protein GPJ68_05705 ENOG4105C85 amino acid GPJ68_05710 ENOG4107R28 alpha amylase, catalytic region GPJ68_05715 ENOG4105EQ1 Transcriptional regulator GPJ68_05720 ENOG4105CHJ isochorismatase hydrolase GPJ68_05730 ENOG4105EFZ amidohydrolase GPJ68_05745 ENOG4105D3R alkyl hydroperoxide reductase GPJ68_05755 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GPJ68_05760 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GPJ68_05765 ENOG4105VIE preprotein translocase, subunit YajC GPJ68_05770 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPJ68_05775 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GPJ68_05790 ENOG4105DRB nucleoside-specific channel-forming protein GPJ68_05795 ENOG4108KIC (LipO)protein GPJ68_05805 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GPJ68_05810 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GPJ68_05815 ENOG4107YIM Involved in the transcription termination process (By similarity) GPJ68_05820 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GPJ68_05825 ENOG4108ZAI phosphatidylglycerophosphatase a GPJ68_05830 ENOG4105CPC Aldo Keto reductase GPJ68_05840 ENOG4105CTB Polyprenyl synthetase GPJ68_05860 ENOG4107S0N DJ-1 family GPJ68_05865 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GPJ68_05870 ENOG4108VPT UPF0234 protein GPJ68_05875 ENOG4107RDB Major Facilitator GPJ68_05900 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) GPJ68_05905 ENOG4105CCU oxidase (Subunit III) GPJ68_05910 ENOG4105BZ9 Cytochrome C oxidase, subunit I GPJ68_05915 ENOG4105E2S oxidase) subunit II GPJ68_05920 ENOG4105EYM Major Facilitator superfamily GPJ68_05925 ENOG4105IEY (LipO)protein GPJ68_05930 ENOG4105M85 Bola protein GPJ68_05945 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GPJ68_05950 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GPJ68_05955 ENOG4105K70 DNA-binding protein GPJ68_05960 ENOG4105EIN peptidylprolyl cis-trans isomerase GPJ68_05965 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein GPJ68_05970 ENOG4108TGP Thioesterase superfamily protein GPJ68_05975 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GPJ68_05980 ENOG4108NFA extracellular solute-binding protein GPJ68_05985 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) GPJ68_05995 ENOG4108XM1 transcriptional regulator AsnC family GPJ68_06000 ENOG4105BZ1 (ABC) transporter GPJ68_06005 ENOG4105BZ1 (ABC) transporter GPJ68_06010 ENOG4108YZA Nitrogen regulatory protein pii GPJ68_06015 ENOG4105BZU Histidine kinase GPJ68_06020 ENOG4105C29 acyl-CoA thioesterase GPJ68_06025 ENOG4108MNP Glycoprotein polysaccharide metabolism GPJ68_06030 ENOG41080UX Methyltransferase GPJ68_06050 ENOG4107U9B transcriptional regulator GPJ68_06055 ENOG4108VW9 Membrane GPJ68_06060 ENOG4105KCV RNA signal recognition particle 4.5S RNA GPJ68_06065 ENOG41066DG (EAL) domain protein GPJ68_06070 ENOG4105NRA 50s ribosomal protein l31 type b GPJ68_06080 ENOG4105GSJ Inner membrane protein ylaC GPJ68_06085 ENOG4108UW5 maltose o-acetyltransferase GPJ68_06095 ENOG4108UKR Biofilm formation regulator YbaJ GPJ68_06100 ENOG4105BZS acriflavin resistance protein GPJ68_06105 ENOG4105C1P efflux transporter, rnd family, mfp subunit GPJ68_06110 ENOG4107XI7 Tetr family transcriptional regulator GPJ68_06115 ENOG4105EGS Mechanosensitive ion channel GPJ68_06120 ENOG4106428 Protein of unknown function (DUF2496) GPJ68_06125 ENOG4108URS primosomal replication protein n'' GPJ68_06130 ENOG4105WD1 Membrane GPJ68_06135 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GPJ68_06140 ENOG4107QMP dna polymerase iii subunits gamma and tau GPJ68_06145 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GPJ68_06150 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GPJ68_06155 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GPJ68_06160 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GPJ68_06175 ENOG4107RE1 Inosine-guanosine kinase GPJ68_06180 ENOG4105CKD glutathione-regulated potassium-efflux system protein GPJ68_06185 ENOG4105EU0 Major facilitator Superfamily GPJ68_06190 ENOG4105CGH 5'-nucleotidase GPJ68_06195 ENOG4108Z66 YbaK ebsC protein GPJ68_06200 ENOG4105MBR gumn family GPJ68_06205 ENOG4105C59 p-type ATPase GPJ68_06210 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GPJ68_06215 ENOG4105EHG Permease protein GPJ68_06225 ENOG41090JE Utilization Protein GPJ68_06230 ENOG4105D4P Coproporphyrinogen iii oxidase GPJ68_06245 ENOG4108Z6Z Transcriptional regulator GPJ68_06260 ENOG4105G5H Membrane GPJ68_06265 ENOG4107QX8 SPFH domain, Band 7 family protein GPJ68_06270 ENOG41083J0 (ABC) transporter GPJ68_06275 ENOG4105C4B ABC transporter, permease GPJ68_06280 ENOG4107QR8 Thioredoxin GPJ68_06285 ENOG4105E1F short-chain dehydrogenase reductase GPJ68_06290 ENOG4108UJV acyl-CoA thioesterase i GPJ68_06295 ENOG4108I0Y (ABC) transporter GPJ68_06300 ENOG4105CV6 ABC transporter, permease GPJ68_06310 ENOG4105D01 (LipO)protein GPJ68_06320 ENOG4108UMI ABC transporter, permease GPJ68_06325 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) GPJ68_06345 ENOG41060W2 glyoxylate carboligase GPJ68_06365 ENOG4107REC cytoplasmic protein GPJ68_06375 ENOG4105C5B carbamate kinase GPJ68_06380 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GPJ68_06385 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GPJ68_06395 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) GPJ68_06405 ENOG4105S2T inner membrane protein YbcI GPJ68_06410 ENOG4105WQ3 Rna-binding protein GPJ68_06415 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GPJ68_06420 ENOG4108WDE Fimbrial protein GPJ68_06430 ENOG4108AF8 Chaperone GPJ68_06435 ENOG4105CW0 outer membrane usher protein GPJ68_06440 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) GPJ68_06445 ENOG4108ZI2 Fimbrial protein GPJ68_06450 ENOG4108Q9V regulatoR GPJ68_06455 ENOG4105F2I Transposase GPJ68_06460 ENOG4106721 fimbriae Y protein GPJ68_06465 ENOG4106KCD HTH_LUXR GPJ68_06480 ENOG4105BZU Histidine kinase GPJ68_06485 ENOG4108SV3 Tmao reductase system periplasmic protein tort GPJ68_06490 ENOG4106WF9 DNA-binding transcriptional regulator TorR GPJ68_06495 ENOG4105CUW cytochrome C-TYPE protein GPJ68_06500 ENOG4108EM1 reductase GPJ68_06510 ENOG4108RW8 Universal stress protein F GPJ68_06515 ENOG4105CUW cytochrome C-TYPE protein GPJ68_06520 ENOG4107QY8 reductase GPJ68_06525 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GPJ68_06545 ENOG4105GR3 Histidine kinase GPJ68_06550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPJ68_06555 ENOG4105ENJ RND efflux system, outer membrane lipoprotein GPJ68_06560 ENOG410624V efflux system protein GPJ68_06565 ENOG4105EP1 Efflux transporter rnd family, mfp subunit GPJ68_06570 ENOG4108IJF Heavy metal efflux pump, CzcA GPJ68_06575 ENOG4108K01 transcriptional regulator GPJ68_06580 ENOG4107QN2 dihydrolipoyl dehydrogenase GPJ68_06585 ENOG41066GK UPF0379 protein ykgI GPJ68_06590 ENOG4108KBJ Inner membrane protein YkgB GPJ68_06595 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) GPJ68_06605 ENOG4105BZU Histidine kinase GPJ68_06625 ENOG4105C85 amino acid GPJ68_06630 ENOG4105EAA nucleoside GPJ68_06650 ENOG4105CUY Mechanosensitive ion channel GPJ68_06665 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GPJ68_06675 ENOG4108IUS Transketolase GPJ68_06680 ENOG4108HHA Transketolase GPJ68_06685 ENOG4105DKT Transcriptional regulator GPJ68_06690 ENOG4105CNN ABC, transporter GPJ68_06695 ENOG4105C2J ABC transporter GPJ68_06705 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPJ68_06710 ENOG4108TSE Transferase GPJ68_06715 ENOG4107RNH Outer membrane receptor FepA GPJ68_06720 ENOG4105E93 esterase GPJ68_06725 ENOG41085A6 mbth domain-containing protein GPJ68_06730 ENOG4105C0W non-ribosomal peptide synthetase GPJ68_06735 ENOG4105E0A ABC, transporter GPJ68_06740 ENOG4105TVJ transport system, permease GPJ68_06745 ENOG4105DQ5 transport system permease protein GPJ68_06750 ENOG4105E8G Major facilitator Superfamily GPJ68_06755 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein GPJ68_06760 ENOG4105E4F Isochorismate synthase GPJ68_06765 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GPJ68_06770 ENOG4105WQI isochorismatase GPJ68_06775 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GPJ68_06780 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) GPJ68_06785 ENOG4105D22 carbon starvation protein GPJ68_06790 ENOG4105VCD cytoplasmic protein GPJ68_06795 ENOG4107SCQ Iron-containing alcohol dehydrogenase GPJ68_06800 ENOG4105CHM Aminotransferase GPJ68_06805 ENOG4105GTN ParB Domain Protein Nuclease GPJ68_06810 ENOG4105BZV Phosphoadenosine phosphosulfate reductase GPJ68_06815 ENOG4105DQS Transcriptional regulator GPJ68_06820 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase GPJ68_06825 ENOG4105D3R alkyl hydroperoxide reductase GPJ68_06830 ENOG4108JU3 Alkyl hydroperoxide reductase GPJ68_06840 ENOG4108J2R molybdopterin oxidoreductase GPJ68_06845 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPJ68_06855 ENOG4108U51 Universal stress protein GPJ68_06860 ENOG4105NXH GreA GreB family elongation factor GPJ68_06875 ENOG4105KTS ribonuclease GPJ68_06880 ENOG4107QPK )-transporter GPJ68_06885 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase GPJ68_06890 ENOG4105YGP holo-ACP synthase CitX GPJ68_06895 ENOG4105CHY citrate lyase, alpha GPJ68_06900 ENOG4105CI0 Citrate lyase GPJ68_06910 ENOG4105DUA (citrate (pro-3S)-lyase ligase GPJ68_06915 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPJ68_06920 ENOG4106YYS transcriptional regulatory protein GPJ68_06925 ENOG4105CEE C4-dicarboxylate transporter GPJ68_06930 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) GPJ68_06960 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) GPJ68_06965 ENOG4108Z43 UPF0250 protein GPJ68_06970 ENOG4105DZ1 carboxypeptidase GPJ68_06975 ENOG4105K6T rare lipoprotein A GPJ68_06980 ENOG4105CNI cell division protein FtsW GPJ68_06985 ENOG4105CJN penicillin-binding protein GPJ68_06990 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GPJ68_06995 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) GPJ68_07000 ENOG4108TGR phosphatase GPJ68_07005 ENOG4107QZB decarboxylase GPJ68_07010 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GPJ68_07015 ENOG4105DJF DNA polymerase III, delta' subunit GPJ68_07025 ENOG4105C8T Leucyl-tRNA synthetase GPJ68_07030 ENOG4107PAI alpha helical protein GPJ68_07050 ENOG4105CDA abc transporter atp-binding protein GPJ68_07055 ENOG4105DRP amino acid AbC transporter GPJ68_07060 ENOG4105EAD ABC transporter GPJ68_07065 ENOG4107RP9 extracellular solute-binding protein, family 3 GPJ68_07070 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) GPJ68_07075 ENOG4108JU5 Magnesium and cobalt efflux protein GPJ68_07080 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GPJ68_07085 ENOG4105C9A Phoh family GPJ68_07090 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GPJ68_07095 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPJ68_07135 ENOG4105CAQ asparagine synthetase GPJ68_07140 ENOG4105D4U had-superfamily hydrolase, subfamily iia GPJ68_07145 ENOG4105E2R ROK family GPJ68_07150 ENOG4105CE4 GlcNAc 6-P deacetylase GPJ68_07160 ENOG4105CI1 PTS System GPJ68_07170 ENOG4105WEM extracellular solute-binding protein GPJ68_07180 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_07185 ENOG4105J5J Outer membrane porin GPJ68_07190 ENOG4105GX6 (LipO)protein GPJ68_07205 ENOG4107EFR Flavocytochrome c GPJ68_07210 ENOG4106P55 Transcriptional regulator GPJ68_07215 ENOG41090R7 Ferric uptake GPJ68_07225 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) GPJ68_07230 ENOG4105NNH LexA regulated protein GPJ68_07235 ENOG4105EV9 Alpha Beta Hydrolase GPJ68_07240 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) GPJ68_07245 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 GPJ68_07250 ENOG4105D5Q Arginine ornithine antiporter GPJ68_07255 ENOG4105CXN decarboxylase GPJ68_07265 ENOG4105EEX Two component transcriptional regulator (Winged helix family GPJ68_07270 ENOG4105C08 Histidine kinase GPJ68_07295 ENOG4105XIQ Protein of unknown function (DUF2517) GPJ68_07300 ENOG4105CVP deoxyribo-dipyrimidine photolyase GPJ68_07315 ENOG4107QNR UPF0135 protein GPJ68_07320 ENOG4105P4J Allophanate hydrolase, subunit 1 GPJ68_07325 ENOG4107R7A Allophanate hydrolase subunit 2 GPJ68_07330 ENOG4105E7W lamb ycsf family protein GPJ68_07345 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GPJ68_07355 ENOG4108KK1 membrane protein AbrB duplication GPJ68_07360 ENOG4105BZN citrate synthase GPJ68_07365 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit GPJ68_07370 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein GPJ68_07375 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) GPJ68_07380 ENOG4105E33 succinate dehydrogenase GPJ68_07385 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 GPJ68_07390 ENOG4105C7S Dehydrogenase GPJ68_07395 ENOG4105CMV Succinyl-CoA synthetase subunit beta GPJ68_07400 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GPJ68_07425 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) GPJ68_07430 ENOG4105MVE transcriptional regulator GPJ68_07445 ENOG4107XVH Transcriptional regulator GPJ68_07450 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GPJ68_07455 ENOG4105ETT transcriptional Regulator, LysR family GPJ68_07460 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GPJ68_07465 ENOG4107GFK fumarate GPJ68_07470 ENOG4105CSV Glutaminase GPJ68_07495 ENOG4105DJI Methylaspartate mutase, E subunit GPJ68_07505 ENOG4107WFU Glutamate mutase subunit sigma GPJ68_07510 ENOG4105C4M (Ubiquinol oxidase) subunit I GPJ68_07515 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPJ68_07525 ENOG4105KJB cyd operon protein YbgE GPJ68_07530 ENOG4107YD3 Thioesterase GPJ68_07535 ENOG4105E02 MotA TolQ exbB proton channel GPJ68_07545 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA GPJ68_07555 ENOG4105KCK Peptidoglycan-associated lipoprotein GPJ68_07560 ENOG4105UFD tol-pal system protein YbgF GPJ68_07600 ENOG4106Z1T Nicotinamide Mononucleotide Transporter GPJ68_07605 ENOG4105PGM cation diffusion facilitator family transporter GPJ68_07610 ENOG4105JND homeobox protein GPJ68_07615 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPJ68_07620 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GPJ68_07625 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) GPJ68_07630 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GPJ68_07635 ENOG4105F0Z galactose-1-phosphate uridylyltransferase GPJ68_07640 ENOG4105CMR udp-glucose 4-epimerase GPJ68_07645 ENOG4105DKW ABC transporter GPJ68_07650 ENOG4105F4R Transcriptional regulator mode GPJ68_07660 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GPJ68_07665 ENOG4105E0C molybdate abc transporter GPJ68_07675 ENOG4108K4B hydrolase GPJ68_07680 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GPJ68_07690 ENOG4105E4C Lytic transglycosylase catalytic GPJ68_07700 ENOG4108VEY type ii secretion system GPJ68_07705 ENOG4107QHF type ii secretion system protein e GPJ68_07725 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C GPJ68_07740 ENOG4105XB6 Toxin coregulated pilin GPJ68_07745 ENOG4105NBR Pectinesterase GPJ68_07755 ENOG41088SP formiminoglutamate hydrolase GPJ68_07765 ENOG4105CGP Urocanate hydratase GPJ68_07770 ENOG4105C84 Histidine ammonia-lyase GPJ68_07775 ENOG4108V1U phospholipid-binding protein GPJ68_07790 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GPJ68_07800 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GPJ68_07805 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GPJ68_07810 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GPJ68_07815 ENOG4108IV0 ABC, transporter GPJ68_07820 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GPJ68_07830 ENOG4105DFD Na H antiporter GPJ68_07835 ENOG4105CHW UPF0052 protein GPJ68_07845 ENOG4108RIR Molybdenum cofactor biosynthesis protein GPJ68_07850 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GPJ68_07855 ENOG4105M00 molybdopterin converting factor, subunit 1 GPJ68_07860 ENOG4108ZAF Molybdopterin GPJ68_07865 ENOG4105HFZ Membrane GPJ68_07870 ENOG4107UXM Membrane GPJ68_07875 ENOG4105DZQ phospholipase D Transphosphatidylase GPJ68_07880 ENOG4105X23 Endonuclease Exonuclease phosphatase GPJ68_07885 ENOG4105I9U inner membrane protein ybhQ GPJ68_07890 ENOG4107QWP ABC-2 type transporter GPJ68_07895 ENOG4107QWP ABC-2 type transporter GPJ68_07900 ENOG4105CJ1 ABC, transporter GPJ68_07905 ENOG4105D0S secretion protein (HlyD GPJ68_07910 ENOG4107MVR Transcriptional regulator GPJ68_07915 ENOG4105C1J atp-dependent rna helicase GPJ68_07920 ENOG4105DVT helicase GPJ68_07925 ENOG4108MTB glycosyl transferase family GPJ68_07930 ENOG4105DG4 malate L-lactate dehydrogenase GPJ68_07935 ENOG4105VR4 UPF0379 protein ybiJ GPJ68_07940 ENOG4105KSC Transcriptional regulator, TraR DksA family GPJ68_07955 ENOG4105ZY9 UPF0379 protein ybiM GPJ68_07960 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) GPJ68_07965 ENOG4105D8X mechanosensitive ion channel GPJ68_07970 ENOG4105CDA abc transporter atp-binding protein GPJ68_07975 ENOG4105E5Q amino acid AbC transporter GPJ68_07980 ENOG4107R0W ABC transporter GPJ68_07985 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction GPJ68_07995 ENOG4108T1M outer membrane protein x GPJ68_08000 ENOG4108I6E Sulfatase GPJ68_08010 ENOG4105KST dependent repressor GPJ68_08015 ENOG4105F4P )-transporter GPJ68_08020 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPJ68_08025 ENOG4105C5H ABC transporter GPJ68_08030 ENOG41072TH Protein of unknown function (DUF1479) GPJ68_08035 ENOG4108HCJ Hydrolase GPJ68_08045 ENOG4105F1A Pyruvate formate-lyase GPJ68_08050 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GPJ68_08055 ENOG4105D06 uba thif-type nad fad binding protein GPJ68_08070 ENOG4105D44 asparaginase GPJ68_08075 ENOG4108JQ6 ABC transporter GPJ68_08080 ENOG4105DEF Extracellular solute-binding protein, family 5 GPJ68_08085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPJ68_08100 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway GPJ68_08105 ENOG4105D8V Glucose sorbosone dehydrogenase GPJ68_08110 ENOG4108TGY Glutathione S-transferase GPJ68_08115 ENOG4105DZ1 carboxypeptidase GPJ68_08120 ENOG4107FB0 transcriptional regulator DeoR family GPJ68_08125 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GPJ68_08130 ENOG4107QF7 multi-drug GPJ68_08140 ENOG4108HCJ Hydrolase GPJ68_08150 ENOG4108RFG Tetr family transcriptional regulator GPJ68_08155 ENOG4105DMW Dehydrogenase reductase GPJ68_08160 ENOG4105D0C transport protein GPJ68_08165 ENOG4105GWF inner membrane protein YbjM GPJ68_08170 ENOG41090BQ Glutaredoxin GPJ68_08175 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress GPJ68_08180 ENOG4108DBC nitroreductase GPJ68_08185 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) GPJ68_08190 ENOG4108RMJ sensory transduction regulator GPJ68_08195 ENOG4107RUE extracellular solute-binding protein family 1 GPJ68_08200 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPJ68_08205 ENOG4105F38 ABC transporter, permease GPJ68_08210 ENOG4105D38 putrescine abc transporter GPJ68_08215 ENOG4105RBQ inner membrane protein ybjO GPJ68_08220 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) GPJ68_08240 ENOG4105CHJ isochorismatase hydrolase GPJ68_08245 ENOG4105EUB pirin domain protein GPJ68_08250 ENOG4105CC0 LysR family Transcriptional regulator GPJ68_08265 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) GPJ68_08270 ENOG4108JJ8 (ABC) transporter GPJ68_08275 ENOG4108JJ9 ABC, transporter GPJ68_08280 ENOG4105C3M thioredoxin reductase GPJ68_08285 ENOG4105EW9 transcriptional regulator AsnC family GPJ68_08290 ENOG4105CNU cell division protein FtsK GPJ68_08300 ENOG4105D1H recombination factor protein RarA GPJ68_08305 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GPJ68_08310 ENOG4107QY8 reductase GPJ68_08315 ENOG4105QAX Iron-sulfur GPJ68_08320 ENOG4107KGK dmso reductase anchor subunit GPJ68_08325 ENOG4105CHJ isochorismatase hydrolase GPJ68_08330 ENOG4108ISG Major Facilitator GPJ68_08335 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GPJ68_08345 ENOG4108HHA Transketolase GPJ68_08365 ENOG4105F1A Pyruvate formate-lyase GPJ68_08370 ENOG4105C6N Formate acetyltransferase GPJ68_08375 ENOG4105TMB Formate nitrite transporter GPJ68_08380 ENOG4105DDY UPF0142 protein ycaO GPJ68_08385 ENOG4107VMU Membrane GPJ68_08390 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GPJ68_08395 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GPJ68_08400 ENOG4105CAT Cytidine monophosphate kinase GPJ68_08405 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GPJ68_08410 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPJ68_08415 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 GPJ68_08420 ENOG4105BZ1 (ABC) transporter GPJ68_08425 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) GPJ68_08430 ENOG4105T0Z Conserved Protein GPJ68_08440 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) GPJ68_08445 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups GPJ68_08450 ENOG4107S90 membrAne GPJ68_08455 ENOG4106371 Methyltransferase GPJ68_08465 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) GPJ68_08470 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) GPJ68_08475 ENOG4105DIT ErfK YbiS YcfS YnhG family protein GPJ68_08480 ENOG4105EAQ (twin-arginine translocation) pathway signal GPJ68_08485 ENOG4105C5X domain protein GPJ68_08490 ENOG4105CGF Aromatic amino acid aminotransferase GPJ68_08505 ENOG4107RH7 Nicotinate phosphoribosyltransferase GPJ68_08510 ENOG4105CD8 aminopeptidase N GPJ68_08520 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GPJ68_08525 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GPJ68_08530 ENOG4105GVF (ABC) transporter GPJ68_08535 ENOG4108UZX fmn reductase GPJ68_08545 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) GPJ68_08550 ENOG4105QVC MOSC domain-containing protein GPJ68_08555 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GPJ68_08560 ENOG4105C5H ABC transporter GPJ68_08565 ENOG4105F1S paraquat-inducible protein a GPJ68_08570 ENOG4105DY2 Paraquat-inducible protein b GPJ68_08575 ENOG4108Q2G (LipO)protein GPJ68_08580 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) GPJ68_08590 ENOG4105DAN ATP-dependent protease GPJ68_08595 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) GPJ68_08600 ENOG4105UYK outer membrane protein a GPJ68_08610 ENOG4108RZ1 DNA transformation protein GPJ68_08615 ENOG4105EM2 membrane GPJ68_08620 ENOG410901E Membrane GPJ68_08625 ENOG41088T4 Helicase IV GPJ68_08630 ENOG4108Z5K methylglyoxal synthase GPJ68_08635 ENOG4108Q67 UPF0319 protein GPJ68_08640 ENOG4105K4P CoA-binding domain protein GPJ68_08655 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 GPJ68_08660 ENOG4108Z0T Part of a sulfur-relay system (By similarity) GPJ68_08700 ENOG4108MN8 Membrane GPJ68_08705 ENOG4108J59 Extracellular solute-binding protein, family 5 GPJ68_08720 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GPJ68_08735 ENOG4105E0A ABC, transporter GPJ68_08740 ENOG4105EHG Permease protein GPJ68_08760 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type GPJ68_08785 ENOG4105DVC DnaJ domain protein GPJ68_08790 ENOG4108Z33 Thiol disulfide Interchange Protein GPJ68_08795 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase GPJ68_08810 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) GPJ68_08815 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GPJ68_08825 ENOG4108ZHR arsR family transcriptional regulator GPJ68_08830 ENOG4105D6F Phosphatase GPJ68_08835 ENOG4105XH3 GPJ68_08840 ENOG4105CS1 NAD(P)H quinone oxidoreductase GPJ68_08845 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 GPJ68_08855 ENOG4108R86 Transcriptional regulator GPJ68_08860 ENOG4105VTN Protein of unknown function (DUF1311) GPJ68_08865 ENOG4105C26 Dehydrogenase GPJ68_08870 ENOG4105CK7 Sodium proline symporter GPJ68_08885 ENOG4105DBE peroxidase GPJ68_08890 ENOG4105D5M phosphate starvation-inducible protein GPJ68_08905 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase GPJ68_08910 ENOG4107SSZ Phosphatase GPJ68_08915 ENOG4107XHZ cytoplasmic chaperone TorD family protein GPJ68_08920 ENOG4108UQ5 membrane protein YcdZ GPJ68_08925 ENOG4105P8Q Curli production assembly transport component CsgG GPJ68_08930 ENOG4108WYR Curli production assembly transport component, CsgF GPJ68_08935 ENOG4108XDW curli assembly protein CsgE GPJ68_08940 ENOG41086KC Transcriptional regulator GPJ68_08945 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers GPJ68_08950 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin GPJ68_08955 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) GPJ68_08960 ENOG41068SS GPJ68_08965 ENOG4108UVJ appr-1-p processing domain protein GPJ68_08970 ENOG4107RZC phospholipase d GPJ68_08985 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) GPJ68_08990 ENOG4105NAC (LipO)protein GPJ68_08995 ENOG4108W47 Acidic protein msyB GPJ68_09000 ENOG4105C6X Major Facilitator GPJ68_09005 ENOG4105D1S lipid A biosynthesis GPJ68_09015 ENOG4108YYC ycei family GPJ68_09020 ENOG4105DS1 cytochrome b561 GPJ68_09025 ENOG4106974 biofilm formation GPJ68_09030 ENOG4105F76 Sarcosine oxidase GPJ68_09035 ENOG4105PVA Biofilm formation regulatory protein BssS GPJ68_09040 ENOG4105MEA DNA damage-inducible protein i GPJ68_09045 ENOG4105EKE dihydroorotase GPJ68_09050 ENOG4105F3T (LipO)protein GPJ68_09055 ENOG4105EV4 Multidrug resistance protein mdtH GPJ68_09060 ENOG4105D9U N-acetyltransferase GPJ68_09070 ENOG4105EP9 oxidoreductase GPJ68_09075 ENOG4105CJR Integral membrane protein (MviN GPJ68_09080 ENOG4105QVD Flagella synthesis protein FlgN GPJ68_09085 ENOG4105M9M anti-sigma28 factor FlgM GPJ68_09090 ENOG4105CKS Flagella basal body P-ring formation protein flgA GPJ68_09095 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GPJ68_09100 ENOG4108ZC9 flagellar basal-body rod protein flgc GPJ68_09105 ENOG4105W00 Flagellar hook capping protein GPJ68_09110 ENOG4105BZE flagellar hook protein, FlgE GPJ68_09115 ENOG4108KPB Flagellar basal-body rod protein FlgF GPJ68_09120 ENOG4105CGA flagellar basal-body rod protein FlgG GPJ68_09130 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) GPJ68_09135 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GPJ68_09140 ENOG4105E1Q flagellar hook-associated protein GPJ68_09145 ENOG4105DTJ flagellar hook-associated protein GPJ68_09150 ENOG4107QQB Ribonuclease E GPJ68_09155 ENOG4105EI2 Pseudouridine synthase GPJ68_09165 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein GPJ68_09170 ENOG4105VGS 50s ribosomal protein l32 GPJ68_09175 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) GPJ68_09180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GPJ68_09185 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GPJ68_09190 ENOG4105CHR reductase GPJ68_09195 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GPJ68_09200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPJ68_09205 ENOG4105YAZ 4-amino-4-deoxychorismate lyase GPJ68_09210 ENOG4105HHA aminodeoxychorismate lyase GPJ68_09215 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GPJ68_09220 ENOG4107QRG dna polymerase iii GPJ68_09225 ENOG4105F8V Hydrolase, tatD family GPJ68_09230 ENOG4105CI1 PTS System GPJ68_09235 ENOG4105DC7 peptidase M24 GPJ68_09240 ENOG4105FYV Amp nucleosidase GPJ68_09245 ENOG4105CSH Transporter GPJ68_09255 ENOG410679B prophage CP4-57 regulatory protein alpA GPJ68_09335 ENOG4108YX2 DNA-binding protein GPJ68_09450 ENOG4105UQX Mate efflux family protein GPJ68_09565 ENOG4108YX2 DNA-binding protein GPJ68_09635 ENOG410679B prophage CP4-57 regulatory protein alpA GPJ68_09645 ENOG4105CNM Receptor GPJ68_09650 ENOG4105K59 histidine triad (HIT) protein GPJ68_09655 ENOG41090DQ Lipoprotein GPJ68_09660 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) GPJ68_09665 ENOG4108RUM thiamine kinase GPJ68_09680 ENOG4105CEP NADH dehydrogenase GPJ68_09685 ENOG4107MBR 17 kDa surface antigen GPJ68_09695 ENOG4108IND Tetr family transcriptional regulator GPJ68_09700 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction GPJ68_09705 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPJ68_09710 ENOG4108JA2 transcriptioN-repair coupling factor GPJ68_09715 ENOG4105IQC Inner membrane protein YcfT GPJ68_09720 ENOG4105D60 lipoprotein releasing system transmembrane protein GPJ68_09725 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) GPJ68_09730 ENOG4105D60 lipoprotein releasing system transmembrane protein GPJ68_09740 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GPJ68_09745 ENOG4108HM4 ABC transporter GPJ68_09750 ENOG4105D38 putrescine abc transporter GPJ68_09765 ENOG4105VEQ Cold shock protein GPJ68_09770 ENOG4105DR8 Membrane GPJ68_09775 ENOG4108YV9 Protein of unknown function (DUF2514) GPJ68_09790 ENOG4106IAW GPJ68_09795 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation GPJ68_09810 ENOG4108YXQ IS66 Orf2 family protein GPJ68_09815 ENOG4105E5H Transposase GPJ68_09825 ENOG4105W3V DNA-binding, transcriptional regulator GPJ68_09845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GPJ68_09850 ENOG4105EZE Cupin 4 family protein GPJ68_09860 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPJ68_09865 ENOG4105FAV ABC, transporter GPJ68_09875 ENOG4105NXV High-affinity zinc uptake system protein GPJ68_09880 ENOG4105DR5 peptidase GPJ68_09885 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase GPJ68_09890 ENOG4105CA9 Pyruvate kinase GPJ68_09895 ENOG4106KNT transcriptional regulator GPJ68_09900 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GPJ68_09905 ENOG4105C01 Dihydroxy-acid dehydratase GPJ68_09910 ENOG4108UHU Aldolase GPJ68_09915 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GPJ68_09920 ENOG4105X2V dna damage-inducible protein GPJ68_09930 ENOG4108Q2J Inner membrane protein YebE GPJ68_09935 ENOG4105CUG Oligopeptidase b GPJ68_09940 ENOG4105UMD exodeoxyribonuclease X GPJ68_09945 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GPJ68_09950 ENOG4105MPK DNA polymerase III subunit theta GPJ68_09955 ENOG4105FXM Copper resistance protein GPJ68_09960 ENOG4108PNC copper resistance GPJ68_09965 ENOG4105NKT exported protein GPJ68_09970 ENOG4108I1J Integrase GPJ68_09975 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 GPJ68_10000 ENOG41076J9 exonuclease VIII GPJ68_10050 ENOG4105JBR DNA replication protein GPJ68_10115 ENOG4105HGD Antitermination protein GPJ68_10160 ENOG4108C66 Inherit from COG: DNA primase GPJ68_10270 ENOG4105PTU response to oxidative stress GPJ68_10280 ENOG4108R1E Serine threonine protein phosphatase 1 GPJ68_10285 ENOG4105UVW uncharacterized protein yebW GPJ68_10290 ENOG4105WT8 Protein of unknown function (DUF1480) GPJ68_10295 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GPJ68_10300 ENOG4105DY2 Paraquat-inducible protein b GPJ68_10305 ENOG4105H2K paraquat-inducible protein a GPJ68_10310 ENOG4108ZGC gaf domain protein GPJ68_10315 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) GPJ68_10320 ENOG4105CN1 protease GPJ68_10325 ENOG4105D0M Protease HtpX homolog GPJ68_10330 ENOG4105D05 Receptor GPJ68_10335 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GPJ68_10345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPJ68_10355 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) GPJ68_10360 ENOG4108MEK Metal-binding protein YodA GPJ68_10365 ENOG4108NIW Leucine export protein LeuE GPJ68_10370 ENOG4108YS1 cytoplasmic protein GPJ68_10375 ENOG4105YP6 Domain of unknown function (DUF1869) GPJ68_10385 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPJ68_10390 ENOG4105Y3U Transglycosylase-associated protein GPJ68_10400 ENOG4106G4W GPJ68_10405 ENOG410620I Diguanylate cyclase GPJ68_10410 ENOG4105UCG Domain of unknown function (DUF333) GPJ68_10415 ENOG4105K78 MarR family Transcriptional regulator GPJ68_10420 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GPJ68_10425 ENOG4105DJ2 Major Facilitator Superfamily GPJ68_10430 ENOG4105R1U AraC Family Transcriptional Regulator GPJ68_10435 ENOG4108VMM UPF0756 membrane protein GPJ68_10440 ENOG4108KXH Ybak prolyl-tRNA synthetase associated GPJ68_10445 ENOG4108KHP Diguanylate cyclase GPJ68_10450 ENOG4105DVA methyltransferase GPJ68_10465 ENOG4105EQK -acetyltransferase GPJ68_10475 ENOG4105CYN Serine protein kinase GPJ68_10480 ENOG4105GNX MltA-interacting MipA family protein GPJ68_10495 ENOG4105CV8 reductase GPJ68_10500 ENOG4105DSB aldose 1-epimerase GPJ68_10505 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPJ68_10515 ENOG4105VUT cytoplasmic protein GPJ68_10520 ENOG4105N1F Hnh endonuclease GPJ68_10530 ENOG4108RWI nicotinamidase GPJ68_10535 ENOG4105HDK L-asparaginase GPJ68_10540 ENOG4105D07 Signal peptide peptidase, SppA GPJ68_10545 ENOG41069NU Nitroreductase GPJ68_10550 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) GPJ68_10555 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPJ68_10560 ENOG4105D82 Glutamate dehydrogenase GPJ68_10565 ENOG4105MTM Protein of unknown function (DUF1496) GPJ68_10570 ENOG4105M6F mutator MutT protein GPJ68_10575 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GPJ68_10580 ENOG4108T9J Cdp-alcohol phosphatidyltransferase GPJ68_10585 ENOG4107RM6 sulfurtransferase GPJ68_10590 ENOG4108VGW abc transporter atp-binding protein GPJ68_10595 ENOG4105CXZ ABC transporter, permease GPJ68_10600 ENOG4105VNH ABC transporter solute-binding protein GPJ68_10605 ENOG4108N5C SNARE associated Golgi protein-related protein GPJ68_10610 ENOG4108RSN SNARE associated Golgi GPJ68_10615 ENOG4105CGK Exodeoxyribonuclease III GPJ68_10620 ENOG4105C8Y Acetylornithine aminotransferase GPJ68_10630 ENOG4105C26 Dehydrogenase GPJ68_10645 ENOG4108SPG Periplasmic Protein GPJ68_10650 ENOG41090B9 response to stress GPJ68_10655 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) GPJ68_10660 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GPJ68_10665 ENOG4105KKI DNA-binding transcriptional activator OsmE GPJ68_10670 ENOG4105VZJ PTS System GPJ68_10675 ENOG4105CK1 PTS System GPJ68_10680 ENOG4105VCP PTS System GPJ68_10685 ENOG4105EZV Transcriptional regulator GPJ68_10690 ENOG4105F8D glycoside hydrolase family 4 GPJ68_10695 ENOG410901P UPF0249 protein GPJ68_10700 ENOG4105CH6 catalase GPJ68_10705 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) GPJ68_10710 ENOG4108ETY sodium dicarboxylate symporter GPJ68_10715 ENOG4107K5X Membrane-bound metal-dependent hydrolase GPJ68_10725 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 GPJ68_10730 ENOG4107PN8 YfeABCD locus regulator GPJ68_10740 ENOG4105DE4 1-phosphofructokinase GPJ68_10745 ENOG4108NE3 Salt-induced outer membrane protein GPJ68_10760 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GPJ68_10765 ENOG41082NX 50s ribosomal protein l35 GPJ68_10790 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) GPJ68_10795 ENOG4105D9N nucleoside GPJ68_10810 ENOG4108RVA ribokinase GPJ68_10825 ENOG4108V06 Glutathione peroxidase GPJ68_10830 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) GPJ68_10835 ENOG4108QBX (LipO)protein GPJ68_10850 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) GPJ68_10855 ENOG4105EHG Permease protein GPJ68_10860 ENOG4107R4I Periplasmic binding protein GPJ68_10865 ENOG4106QJH hemin transport protein GPJ68_10870 ENOG4107ENK receptor GPJ68_10880 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPJ68_10890 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GPJ68_10895 ENOG4105CEY Amp-dependent synthetase and ligase GPJ68_10900 ENOG41090P5 ferredoxin-like protein GPJ68_10905 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPJ68_10910 ENOG4105C10 Electron transfer flavoprotein GPJ68_10915 ENOG4105CV7 Electron transfer flavoprotein GPJ68_10920 ENOG4105W4W Transcriptional regulator GPJ68_10925 ENOG4105C1G acyl-Coa dehydrogenase GPJ68_10930 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) GPJ68_10945 ENOG4105EMV Major Facilitator GPJ68_10950 ENOG4105EMV Major Facilitator GPJ68_10955 ENOG4105SUA Ydil protein GPJ68_10965 ENOG4105IPI Membrane GPJ68_10970 ENOG4105CQB FAD linked oxidase domain protein GPJ68_10975 ENOG4105KA0 thioesterase Superfamily protein GPJ68_10980 ENOG410671Z uncharacterized protein ydiH GPJ68_10990 ENOG4105EXG Transcriptional regulator GPJ68_11005 ENOG4108Z4V iron-sulfur cluster assembly GPJ68_11010 ENOG4105DIW FeS assembly protein SUFB GPJ68_11015 ENOG4105C3K feS assembly ATPase SufC GPJ68_11020 ENOG4105JRK feS assembly protein SufD GPJ68_11025 ENOG4105C9B Cysteine desulfurase GPJ68_11035 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GPJ68_11045 ENOG4105CA9 Pyruvate kinase GPJ68_11055 ENOG4108UMI ABC transporter, permease GPJ68_11060 ENOG4105D01 (LipO)protein GPJ68_11065 ENOG4105DB1 molybdopterin oxidoreductase GPJ68_11070 ENOG4106WHD Tetrathionate reductase GPJ68_11075 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPJ68_11080 ENOG4106AFQ Histidine kinase GPJ68_11085 ENOG4108ZXC Two component transcriptional regulator, luxr family GPJ68_11090 ENOG4105RFR Protein of unknown function (DUF2767) GPJ68_11095 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein GPJ68_11100 ENOG4105WE2 aldehyde ferredoxin oxidoreductase GPJ68_11105 ENOG4105JVW GPJ68_11110 ENOG4108393 oxidoreductase Fe-S subunit GPJ68_11115 ENOG4108NWD Cytochrome GPJ68_11120 ENOG4108Y7C Conserved Protein GPJ68_11125 ENOG4105DRP amino acid AbC transporter GPJ68_11130 ENOG4105E5Q amino acid AbC transporter GPJ68_11140 ENOG4105CT1 (ABC) transporter GPJ68_11150 ENOG4105C85 amino acid GPJ68_11165 ENOG4105C26 Dehydrogenase GPJ68_11190 ENOG4108JPW Aminotransferase GPJ68_11195 ENOG4105S10 periplasmic binding protein GPJ68_11200 ENOG4105EHG Permease protein GPJ68_11205 ENOG4108W0P ABC transporter GPJ68_11210 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein GPJ68_11225 ENOG4108V06 Glutathione peroxidase GPJ68_11245 ENOG4107RTG Major Facilitator superfamily GPJ68_11250 ENOG4105ENX hydrolase GPJ68_11255 ENOG4105EQ2 LysR family Transcriptional regulator GPJ68_11275 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GPJ68_11285 ENOG4105VSH 4-oxalocrotonate tautomerase GPJ68_11320 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GPJ68_11335 ENOG4105F4G Membrane GPJ68_11345 ENOG4105BZU Histidine kinase GPJ68_11365 ENOG4105KME endoribonuclease L-psp GPJ68_11370 ENOG4105N0V mono-oxygenase ydhR GPJ68_11375 ENOG4105JAB phenazine biosynthesis protein, phzf family GPJ68_11380 ENOG4105D3G Pseudouridine synthase GPJ68_11390 ENOG4108R6K riboflavin synthase, subunit alpha GPJ68_11395 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GPJ68_11400 ENOG4105CZQ inner membrane transport protein YdhC GPJ68_11405 ENOG4105F52 Transcriptional regulator GPJ68_11410 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_11420 ENOG4105F27 Major Facilitator GPJ68_11425 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPJ68_11430 ENOG4105K4H Nlp p60 protein GPJ68_11435 ENOG4105M2J Glutaredoxin GPJ68_11440 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) GPJ68_11445 ENOG4108UYE Lactoylglutathione lyase GPJ68_11450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPJ68_11455 ENOG4108WUH Transcriptional regulator, TetR family GPJ68_11460 ENOG4105XZD Fe-S protein GPJ68_11465 ENOG4107RGM aldo keto reductase GPJ68_11470 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPJ68_11475 ENOG4105DSW Fusaric acid resistance protein GPJ68_11480 ENOG4105Y49 secretion protein, HlyD family GPJ68_11495 ENOG4108XTF Outer Membrane Lipoprotein GPJ68_11500 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) GPJ68_11505 ENOG410642K Lysozyme inhibitor GPJ68_11515 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GPJ68_11520 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GPJ68_11525 ENOG4108K3A Glutathione S-transferase GPJ68_11530 ENOG4105DUX Transporter GPJ68_11535 ENOG4105CSM endonuclease III GPJ68_11540 ENOG4105DZB Electron transport complex GPJ68_11545 ENOG4108UQQ Electron transport complex GPJ68_11550 ENOG4105D6A Electron transport complex GPJ68_11560 ENOG4108R3D Electron transport complex GPJ68_11570 ENOG4105M9B inner membrane protein ydgK GPJ68_11575 ENOG4105QZ5 OriC-binding nucleoid-associated protein GPJ68_11580 ENOG4106C6R beta-lactam resistance protein GPJ68_11585 ENOG4105D9R oxidoreductase GPJ68_11595 ENOG4105C87 Aminotransferase class I and II GPJ68_11600 ENOG4105CI1 PTS System GPJ68_11605 ENOG4107P2S Transcriptional regulator GPJ68_11610 ENOG4106J39 exported protein GPJ68_11615 ENOG4105EIP mannose-6-phosphate isomerase GPJ68_11620 ENOG4107GFK fumarate GPJ68_11625 ENOG4105C9Q fumarate hydratase class II GPJ68_11630 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) GPJ68_11635 ENOG4105JJR Histidine kinase GPJ68_11660 ENOG4107EXC regulatoR GPJ68_11665 ENOG4105RA2 Membrane GPJ68_11670 ENOG410642E Short chain dehydrogenase GPJ68_11675 ENOG4105D5Q Arginine ornithine antiporter GPJ68_11680 ENOG4105C5D exported protein GPJ68_11685 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPJ68_11690 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) GPJ68_11695 ENOG4105C2C drug resistance transporter, Bcr CflA GPJ68_11700 ENOG4105DSF transport protein GPJ68_11710 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) GPJ68_11720 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap GPJ68_11730 ENOG4105CTD carboxy-peptidase GPJ68_11735 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) GPJ68_11745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GPJ68_11750 ENOG4105ES5 Histidine kinase GPJ68_11760 ENOG4105D94 Major Facilitator Superfamily GPJ68_11765 ENOG4106NZI LysR family Transcriptional regulator GPJ68_11770 ENOG4105DAG ROK family GPJ68_11775 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) GPJ68_11780 ENOG4105CMQ Chloride channel GPJ68_11785 ENOG4108NEM leader-binding protein dmsD GPJ68_11790 ENOG4107KGK dmso reductase anchor subunit GPJ68_11795 ENOG4105QAX Iron-sulfur GPJ68_11835 ENOG4107QY8 reductase GPJ68_11840 ENOG4105KBG Protein of unknown function (DUF1161) GPJ68_11850 ENOG4108MK9 spermidine N(1)-acetyltransferase GPJ68_11855 ENOG4105M5Q UPF0482 protein GPJ68_11860 ENOG4105KK4 UPF0060 membrane protein GPJ68_11865 ENOG4105CXK mandelate racemase muconate lactonizing GPJ68_11875 ENOG4105DEI Mannitol dehydrogenase GPJ68_11880 ENOG41061EV selenium-binding protein YdfZ GPJ68_11885 ENOG4107XBN GntR Family Transcriptional Regulator GPJ68_11890 ENOG4105EMU Dehydrogenase GPJ68_11895 ENOG4105DGW oligopeptidase A GPJ68_11910 ENOG4105C32 Amino acid ABC transporter (Permease) GPJ68_11915 ENOG4105CNN ABC, transporter GPJ68_11925 ENOG4108IV0 ABC, transporter GPJ68_11930 ENOG4105E5W Transporter GPJ68_11935 ENOG4108594 Permease of the drug metabolite transporter GPJ68_11940 ENOG4106DNR multiple antibiotic resistance protein GPJ68_11945 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF GPJ68_11950 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GPJ68_11960 ENOG4105F27 Major Facilitator GPJ68_11965 ENOG4105EGI Transcriptional regulator GPJ68_11970 ENOG4105C26 Dehydrogenase GPJ68_11975 ENOG4105CSV Glutaminase GPJ68_11980 ENOG4105M0C cytoplasmic protein GPJ68_12215 ENOG4105CDY transcriptional regulatory protein GPJ68_12220 ENOG4105VYA Uncharacterized conserved protein (DUF2132) GPJ68_12225 ENOG4105F32 YngK protein GPJ68_12240 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GPJ68_12245 ENOG4105C85 amino acid GPJ68_12250 ENOG4105SUV lipoprotein YgdR GPJ68_12255 ENOG4108NS2 receptor GPJ68_12260 ENOG4105CHB tonB-dependent Receptor GPJ68_12265 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GPJ68_12275 ENOG4108Z7F N-acetyltransferase GPJ68_12280 ENOG4108T9Y Inner membrane protein ydcZ GPJ68_12285 ENOG4105R71 cytoplasmic protein GPJ68_12290 ENOG4105DEF Extracellular solute-binding protein, family 5 GPJ68_12310 ENOG410654E Membrane GPJ68_12325 ENOG4105C2C drug resistance transporter, Bcr CflA GPJ68_12330 ENOG4105C26 Dehydrogenase GPJ68_12335 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component GPJ68_12340 ENOG4105D81 ABC transporter, permease GPJ68_12345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GPJ68_12350 ENOG4107TYH extracellular solute-binding protein family 1 GPJ68_12355 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPJ68_12360 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin GPJ68_12370 ENOG4105C4M (Ubiquinol oxidase) subunit I GPJ68_12375 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GPJ68_12385 ENOG4105RR0 Protein of unknown function (DUF2554) GPJ68_12390 ENOG4105CFP Peptidase U32 GPJ68_12395 ENOG4108JCI Transcriptional regulator GPJ68_12400 ENOG4105DKK Benzoate GPJ68_12415 ENOG4108KKZ (LipO)protein GPJ68_12420 ENOG41088CC tellurite resistance protein tehB GPJ68_12425 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein GPJ68_12430 ENOG4107WE3 acetyltransferase YdcK GPJ68_12435 ENOG4108Z9I -acetyltransferase GPJ68_12440 ENOG4105Z2P Protein of unknown function (DUF465) GPJ68_12450 ENOG4105E32 cytoplasmic protein GPJ68_12455 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GPJ68_12460 ENOG4105DDW LysR family Transcriptional regulator GPJ68_12465 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_12485 ENOG4105D6F Phosphatase GPJ68_12490 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GPJ68_12495 ENOG4105KT5 UmuD protein GPJ68_12500 ENOG4105CPW cytochrome b561 GPJ68_12505 ENOG4105C26 Dehydrogenase GPJ68_12510 ENOG4107DB1 DUF218 domain GPJ68_12515 ENOG4105CQ7 ATP-dependent helicase GPJ68_12520 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GPJ68_12530 ENOG4105WXT Conserved Protein GPJ68_12535 ENOG410689M (LipO)protein GPJ68_12540 ENOG4107H52 Dicarboxylate transport GPJ68_12550 ENOG4105C5I Dehydrogenase GPJ68_12555 ENOG41090X5 Heat shock protein hslJ GPJ68_12560 ENOG4105IKK cytoplasmic protein GPJ68_12570 ENOG4105FCK Membrane GPJ68_12580 ENOG4108RW8 Universal stress protein F GPJ68_12585 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) GPJ68_12590 ENOG4105C1J atp-dependent rna helicase GPJ68_12605 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_12610 ENOG4105BZU Histidine kinase GPJ68_12615 ENOG4105BZU Histidine kinase GPJ68_12620 ENOG4108DG9 Smr protein MutS2 GPJ68_12625 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GPJ68_12630 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPJ68_12635 ENOG4105Q9Y Universal stress protein GPJ68_12640 ENOG4105S5I Membrane GPJ68_12645 ENOG4105D64 Mechanosensitive ion channel GPJ68_12660 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GPJ68_12665 ENOG4105MVE transcriptional regulator GPJ68_12670 ENOG4107QSI ABC, transporter GPJ68_12675 ENOG4105KXI murein peptide amidase A GPJ68_12680 ENOG4107S8C mandelate racemase muconate lactonizing GPJ68_12685 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GPJ68_12695 ENOG4106K28 UPF0283 membrane protein GPJ68_12700 ENOG4105CM6 amino acid regulated cytosolic protein GPJ68_12705 ENOG4105K8Z Phage shock protein GPJ68_12710 ENOG4105FKQ transcriptional regulator GPJ68_12715 ENOG4107EFV Outer membrane protein G GPJ68_12725 ENOG4107URF beta-phospho-glucomutase GPJ68_12730 ENOG4105C71 hydrolase family 65, central catalytic GPJ68_12735 ENOG4105CK5 oxidoreductase GPJ68_12740 ENOG4107TYA transient receptor potential locus GPJ68_12745 ENOG4107RRD Dehydrogenase GPJ68_12750 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GPJ68_12755 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component GPJ68_12760 ENOG4105WEM extracellular solute-binding protein GPJ68_12770 ENOG4107QW3 Sucrose phosphorylase GPJ68_12775 ENOG4105NNG Peripheral inner membrane phage-shock protein GPJ68_12780 ENOG4105FM1 phage shock protein C GPJ68_12785 ENOG4105YYT phage shock protein B GPJ68_12790 ENOG41087YS Phage shock protein A GPJ68_12795 ENOG4105E51 psp operon transcriptional activator GPJ68_12810 ENOG4108J59 Extracellular solute-binding protein, family 5 GPJ68_12815 ENOG4108EKA peptide transport system, permease GPJ68_12820 ENOG4108EU3 peptide transport system, permease GPJ68_12825 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein GPJ68_12830 ENOG4108JQ2 peptide transport system atp-binding protein GPJ68_12840 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GPJ68_12845 ENOG4105Q4T oxidoreductase GPJ68_12855 ENOG4105BZU Histidine kinase GPJ68_12860 ENOG4106BSC UPF0509 protein GPJ68_12865 ENOG4105N2W Transcriptional regulator GPJ68_12875 ENOG4108ZJT translation initiation factor, Sui1 GPJ68_12885 ENOG4105CFV Tetratricopeptide repeat protein GPJ68_12890 ENOG4105Q4A inner membrane protein yciS GPJ68_12895 ENOG4105EYK Phosphatidylglycerophosphatase B GPJ68_12905 ENOG4107QM5 aconitate hydratase GPJ68_12915 ENOG4107R11 Transcriptional regulator GPJ68_12920 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GPJ68_12925 ENOG4105RKX Protein of unknown function (DUF2498) GPJ68_12930 ENOG4105ERU peptidase GPJ68_12935 ENOG4105UBK short-chain dehydrogenase reductase GPJ68_12940 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase GPJ68_12945 ENOG4105FE9 pseudouridine synthase GPJ68_12950 ENOG4107RTD sua5 ycio yrdc ywlc family protein GPJ68_12955 ENOG4105DB7 PHP domain protein GPJ68_12965 ENOG4105CRQ synthase (Component I) GPJ68_12970 ENOG4108EFP Anthranilate synthase component II GPJ68_12975 ENOG4105DK0 Indole-3-glycerol phosphate synthase GPJ68_12980 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GPJ68_12985 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) GPJ68_13000 ENOG4105EIF outer membrane protein W GPJ68_13005 ENOG4108S3I UPF0259 membrane protein GPJ68_13010 ENOG4107835 probably involved in intracellular septation (By similarity) GPJ68_13015 ENOG4105NAU thioesterase Superfamily protein GPJ68_13020 ENOG410822N TonB family GPJ68_13025 ENOG4105K9H YciI-like protein GPJ68_13035 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GPJ68_13045 ENOG4105EYW Ion transport protein GPJ68_13050 ENOG4108JQ7 (ABC) transporter GPJ68_13055 ENOG4105C3U ABC transporter GPJ68_13060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GPJ68_13065 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GPJ68_13070 ENOG4107QSI ABC, transporter GPJ68_13075 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GPJ68_13080 ENOG4105C0A alcohol dehydrogenase GPJ68_13085 ENOG4107104 thymidine kinase GPJ68_13095 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPJ68_13100 ENOG4105I93 response regulator GPJ68_13105 ENOG4105D78 K07001 NTE family protein GPJ68_13115 ENOG4105CIY formyltetrahydrofolate deformylase GPJ68_13140 ENOG41076YT nitrate reductase, gamma subunit GPJ68_13145 ENOG4105R3A Nitrate reductase GPJ68_13150 ENOG4108IUE nitrate reductase beta subunit GPJ68_13155 ENOG4105CRU nitrate reductase, alpha subunit GPJ68_13160 ENOG4105DQQ Major facilitator superfamily MFS_1 GPJ68_13165 ENOG4105BZU Histidine kinase GPJ68_13170 ENOG4105WH1 Two component transcriptional regulator luxr family GPJ68_13175 ENOG4105ID0 Putative invasin GPJ68_13180 ENOG41090EX DsrE family GPJ68_13190 ENOG4108NH8 Cation transport protein GPJ68_13195 ENOG4105WS7 Cation transport regulator GPJ68_13200 ENOG4105EWV Sodium calcium exchanger membrane region GPJ68_13210 ENOG41063JG Transcriptional regulator GPJ68_13215 ENOG4108YY7 Invasion gene expression up-regulator SirB GPJ68_13220 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GPJ68_13225 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GPJ68_13230 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GPJ68_13235 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) GPJ68_13245 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GPJ68_13250 ENOG4105CHH sulfate transporter GPJ68_13255 ENOG4105DY8 decarboxylase GPJ68_13270 ENOG4105CFH Aspartokinase GPJ68_13275 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria GPJ68_13285 ENOG4105C3G gtp-binding protein GPJ68_13290 ENOG4105ENX hydrolase GPJ68_13300 ENOG4105GR3 Histidine kinase GPJ68_13345 ENOG4105D82 Glutamate dehydrogenase GPJ68_13350 ENOG4105CMT Dihydroxyacetone kinase GPJ68_13355 ENOG4108UTZ Dihydroxyacetone kinase GPJ68_13365 ENOG4105E53 ec 3.2.1.28 GPJ68_13370 ENOG4105S10 periplasmic binding protein GPJ68_13375 ENOG4105EHG Permease protein GPJ68_13380 ENOG4105E0A ABC, transporter GPJ68_13385 ENOG4108BSC Methyltransferase GPJ68_13390 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GPJ68_13405 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) GPJ68_13415 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GPJ68_13425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GPJ68_13430 ENOG4105MWK D-amino acid dehydrogenase, small subunit GPJ68_13435 ENOG4105ED1 spovr family GPJ68_13450 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) GPJ68_13460 ENOG4108ZZ3 UPF0260 protein GPJ68_13465 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase GPJ68_13470 ENOG4105VNG YcgL domain-containing protein GPJ68_13480 ENOG4107QMS site-determining protein GPJ68_13490 ENOG4105EJC lysr family transcriptional regulator GPJ68_13495 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GPJ68_13500 ENOG4105C94 Transporter GPJ68_13505 ENOG4105DVW rieske (2Fe-2S) GPJ68_13510 ENOG4105E3J oxidoreductase GPJ68_13515 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) GPJ68_13520 ENOG4105CEY Amp-dependent synthetase and ligase GPJ68_13525 ENOG4105Y4Z Outer Membrane Lipoprotein GPJ68_13530 ENOG41072GX Peptidase M22 Glycoprotease GPJ68_13535 ENOG4105DVT helicase GPJ68_13540 ENOG4105M4H endoribonuclease L-psp GPJ68_13545 ENOG4105X5C UPF0181 protein GPJ68_13550 ENOG4105CRQ synthase (Component I) GPJ68_13560 ENOG4105EJQ L-serine dehydratase GPJ68_13565 ENOG4107XTP (EAL) domain protein GPJ68_13570 ENOG4105EE5 Membrane protein terC GPJ68_13575 ENOG4105DAS pts system GPJ68_13580 ENOG4105ETZ PTS System GPJ68_13585 ENOG4105F3R pts system mannose fructose sorbose family iid GPJ68_13590 ENOG4108NK4 UPF0266 membrane protein GPJ68_13600 ENOG4105DHI Methyltransferase GPJ68_13605 ENOG4105CJN penicillin-binding protein GPJ68_13620 ENOG4105Q3Y exported protein GPJ68_13625 ENOG4107BVS GPJ68_13630 ENOG4105TIK GPJ68_13635 ENOG4105J4Q Transcriptional regulator GPJ68_13640 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPJ68_13645 ENOG4108HMX isocitrate dehydrogenase (NADP) GPJ68_13660 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GPJ68_13670 ENOG4107QTF adenylosuccinate lyase GPJ68_13675 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GPJ68_13685 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) GPJ68_13690 ENOG4105CDY transcriptional regulatory protein GPJ68_13695 ENOG4108TIT dATP pyrophosphohydrolase GPJ68_13700 ENOG4105C9M aspartyl-trna synthetase GPJ68_13705 ENOG4105D3W isochorismatase GPJ68_13815 ENOG4105EFC phage portal protein HK97 family GPJ68_13825 ENOG4105CAR Terminase, large subunit GPJ68_13855 ENOG4105NVB glycoside hydrolase, family 19 GPJ68_13885 ENOG4105HRS Antitermination protein GPJ68_13890 ENOG4108MXB Protein of unknown function (DUF968) GPJ68_13905 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GPJ68_14005 ENOG4107R08 Integrase GPJ68_14010 ENOG41081XQ Conserved Protein GPJ68_14015 ENOG4105WJG Glutathione GPJ68_14025 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) GPJ68_14030 ENOG4106N3A copper homeostasis protein cutc GPJ68_14035 ENOG4106ZCM YecM protein GPJ68_14040 ENOG4105C75 arginyL-tRNA synthetase GPJ68_14050 ENOG4105F5H Glycosyl Hydrolase Family 88 GPJ68_14055 ENOG4105CT4 transporter GPJ68_14060 ENOG4105IRD Flagellar protein FlhE GPJ68_14065 ENOG4105D7B Flagellar biosynthesis protein flha GPJ68_14070 ENOG4105D00 flagellar biosynthetic protein flhB GPJ68_14085 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPJ68_14090 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) GPJ68_14095 ENOG4108VYJ response regulator receiver protein GPJ68_14100 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GPJ68_14105 ENOG4105BZU Histidine kinase GPJ68_14110 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_14115 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_14120 ENOG4107QJT sodium dicarboxylate symporter GPJ68_14125 ENOG4108V3W Chemotaxis protein, CheW GPJ68_14130 ENOG4105CBS Chea signal transduction histidine kinase GPJ68_14135 ENOG4105ER2 Ompa motb domain protein GPJ68_14140 ENOG4107RD7 Flagellar Motor Protein, MotA GPJ68_14145 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region GPJ68_14150 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) GPJ68_14155 ENOG4108VA4 Universal stress protein GPJ68_14160 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase GPJ68_14165 ENOG4108K4C ec 3.1.3.12 GPJ68_14170 ENOG4105CNN ABC, transporter GPJ68_14175 ENOG4105C2J ABC transporter GPJ68_14180 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator GPJ68_14190 ENOG4108UEC Ferritin-like protein GPJ68_14195 ENOG4105N4N Protein of unknown function (DUF2766) GPJ68_14200 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPJ68_14210 ENOG4105P23 (LipO)protein GPJ68_14215 ENOG41090A1 ferritin GPJ68_14220 ENOG4105VVZ metal-binding protein GPJ68_14225 ENOG4105E0U tyrosine-specific transport protein GPJ68_14230 ENOG4106RHG Yeca family GPJ68_14235 ENOG410681U heavy metal transport detoxification protein GPJ68_14245 ENOG4108KS2 transglutaminase domain protein GPJ68_14280 ENOG4105KBH arsR family transcriptional regulator GPJ68_14285 ENOG4105CAU Arsenical resistance protein, ArsH GPJ68_14290 ENOG4105F9F transposase GPJ68_14295 ENOG4105VEQ Cold shock protein GPJ68_14300 ENOG41060EU Cold shock-like protein GPJ68_14325 ENOG4105DZR Type I site-specific deoxyribonuclease GPJ68_14360 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GPJ68_14365 ENOG4105WH1 Two component transcriptional regulator luxr family GPJ68_14370 ENOG4105XVG cytoplasmic protein GPJ68_14375 ENOG4105VJY transcriptional regulator GPJ68_14380 ENOG4105CDA abc transporter atp-binding protein GPJ68_14385 ENOG4105E5Q amino acid AbC transporter GPJ68_14390 ENOG4105K6H D-cysteine desulfhydrase GPJ68_14395 ENOG4105EAB amino acid AbC transporter GPJ68_14400 ENOG4108M9K flagella biosynthesis protein FliZ GPJ68_14405 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPJ68_14420 ENOG4105DTS flagellar hook-associated GPJ68_14425 ENOG4105MQ3 flagellar protein FliS GPJ68_14435 ENOG4105E5K Alpha-amylase GPJ68_14440 ENOG4105JCU Inherit from NOG: (Lipo)protein GPJ68_14445 ENOG41066VF YeeE YedE family protein GPJ68_14460 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GPJ68_14465 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPJ68_14470 ENOG41090PJ Flagellar assembly protein GPJ68_14475 ENOG4108JIR Flagellum-specific ATP synthase GPJ68_14480 ENOG4105GSA Flagellar export protein flij GPJ68_14485 ENOG4105WF4 Flagellar hook-length control protein GPJ68_14490 ENOG4107ZI8 flagellar basal body-associated protein flil GPJ68_14495 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GPJ68_14500 ENOG4105DD5 Flagellar motor switch protein GPJ68_14505 ENOG4105K0P flagellar biosynthesis protein GPJ68_14510 ENOG4105CN7 Flagellar biosynthetic protein FliP GPJ68_14515 ENOG4105VS8 Flagellar biosynthetic protein fliq GPJ68_14520 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GPJ68_14525 ENOG4107TKS colanic acid capsular biosynthesis activation protein A GPJ68_14530 ENOG4105VZF DsrB protein GPJ68_14535 ENOG4105YX3 cellular response to acidity GPJ68_14540 ENOG4105VNZ cytoplasmic protein GPJ68_14545 ENOG4105CKW Inner membrane protein yedI GPJ68_14550 ENOG4105FDR Membrane GPJ68_14555 ENOG41090BB DNA mismatch endonuclease (vsr) GPJ68_14560 ENOG4105DVF Cytosine-specific methyltransferase GPJ68_14565 ENOG4105EST Metal Dependent Phosphohydrolase GPJ68_14570 ENOG4105ZIT Porin Gram-negative type GPJ68_14725 ENOG410679B prophage CP4-57 regulatory protein alpA GPJ68_14750 ENOG4106KNT transcriptional regulator GPJ68_14770 ENOG4105CHR reductase GPJ68_14780 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF GPJ68_14785 ENOG4105F2I Transposase GPJ68_14790 ENOG4105Y49 secretion protein, HlyD family GPJ68_14805 ENOG4105R1U AraC Family Transcriptional Regulator GPJ68_14870 ENOG4108V42 Type IV secretion system protein VirB8 GPJ68_14875 ENOG4108PCE TRANSFER protein GPJ68_14970 ENOG4107RCV ABC transporter, permease GPJ68_14980 ENOG4108PXI ErfK YbiS YcfS YnhG GPJ68_14985 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) GPJ68_14990 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) GPJ68_14995 ENOG4108YZT Adenosylcobinamide kinase GPJ68_15000 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GPJ68_15010 ENOG4108V4M Cobalt abc transporter GPJ68_15015 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GPJ68_15020 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) GPJ68_15025 ENOG4105DVK Precorrin-2 c20-methyltransferase GPJ68_15030 ENOG4107PPM cobalt chelatase GPJ68_15035 ENOG4105QUC reductase GPJ68_15040 ENOG4105E4R Precorrin-3B C17-methyltransferase GPJ68_15045 ENOG4108P62 biosynthesis protein (CbiG) GPJ68_15050 ENOG4105CIA precorrin-4 C(11)-methyltransferase GPJ68_15055 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase GPJ68_15060 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase GPJ68_15065 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) GPJ68_15070 ENOG41081F0 Precorrin-8x methylmutase GPJ68_15075 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) GPJ68_15080 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) GPJ68_15085 ENOG4107XVH Transcriptional regulator GPJ68_15090 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPJ68_15095 ENOG4105KNY Microcompartments protein GPJ68_15100 ENOG4105EHR propanediol utilization protein pduB GPJ68_15105 ENOG4105DMB glycerol dehydratase GPJ68_15110 ENOG4105YCI dehydratase medium subunit GPJ68_15115 ENOG4108ZFT Dehydratase small subunit GPJ68_15120 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit GPJ68_15130 ENOG4105KNY Microcompartments protein GPJ68_15140 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) GPJ68_15150 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GPJ68_15160 ENOG4108EKI Dehydrogenase GPJ68_15170 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) GPJ68_15180 ENOG4105M3W utilization protein GPJ68_15185 ENOG4105KTW ethanolamine utilization protein GPJ68_15190 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPJ68_15195 ENOG4105JZC GHMP kinase GPJ68_15205 ENOG4105DR8 Membrane GPJ68_15210 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) GPJ68_15215 ENOG4105DZ1 carboxypeptidase GPJ68_15220 ENOG4108NWD Cytochrome GPJ68_15225 ENOG4105QAX Iron-sulfur GPJ68_15230 ENOG4108J2R molybdopterin oxidoreductase GPJ68_15235 ENOG4105CJB Exodeoxyribonuclease I GPJ68_15240 ENOG4105CUB amino acid GPJ68_15250 ENOG4105EQ1 Transcriptional regulator GPJ68_15255 ENOG4107SRH Nad-dependent epimerase dehydratase GPJ68_15270 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GPJ68_15275 ENOG4105CIH Imidazole acetol-phosphate transaminase GPJ68_15280 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GPJ68_15285 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GPJ68_15290 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GPJ68_15300 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GPJ68_15305 ENOG4105C6Y Udp-glucose 6-dehydrogenase GPJ68_15310 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GPJ68_15320 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GPJ68_15325 ENOG4107EF8 Glycosyl transferase (Group 1 GPJ68_15335 ENOG4105EY8 ABC transporter GPJ68_15345 ENOG4107SJB teichoic acid biosynthesis GPJ68_15350 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GPJ68_15355 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GPJ68_15360 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GPJ68_15365 ENOG4105G1A colanic acid biosynthesis protein GPJ68_15370 ENOG4107T8Q Glycosyl transferase (Group 1 GPJ68_15375 ENOG4105C74 pyruvyl transferase GPJ68_15380 ENOG4105PSV Polysaccharide Biosynthesis Protein GPJ68_15385 ENOG4105D3Q Sugar transferase GPJ68_15390 ENOG4107QKV phosphomannomutase GPJ68_15395 ENOG4105CJT Mannose-1-phosphate guanylyltransferase GPJ68_15400 ENOG4106CD9 glycosyl transferase group 1 GPJ68_15405 ENOG4105FGF GDP-mannose mannosyl hydrolase GPJ68_15410 ENOG4105C30 Nad-dependent epimerase dehydratase GPJ68_15415 ENOG4105C0K Gdp-mannose 4,6-dehydratase GPJ68_15420 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF GPJ68_15425 ENOG4105ECJ Glycosyl Transferase GPJ68_15430 ENOG4108NYJ Colanic acid GPJ68_15435 ENOG4107RXY Glycosyl transferase GPJ68_15440 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB GPJ68_15445 ENOG41090RK glycosyl transferase GPJ68_15450 ENOG4105D75 Capsular exopolysaccharide family GPJ68_15455 ENOG4105KJF protein tyrosine phosphatase GPJ68_15460 ENOG4105DAY polysaccharide export protein GPJ68_15465 ENOG4105EE5 Membrane protein terC GPJ68_15470 ENOG4108GAE asmA family GPJ68_15475 ENOG4105DHP deoxycytidine triphosphate deaminase GPJ68_15485 ENOG4105BZU Histidine kinase GPJ68_15490 ENOG4105D03 DNA-3-methyladenine glycosylase II GPJ68_15495 ENOG4105R8A Heat shock protein GPJ68_15510 ENOG4105BZS acriflavin resistance protein GPJ68_15515 ENOG4105BZS acriflavin resistance protein GPJ68_15520 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPJ68_15525 ENOG4105EB3 Histidine kinase GPJ68_15530 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPJ68_15535 ENOG4105KWI UPF0339 protein GPJ68_15540 ENOG4105CFP Peptidase U32 GPJ68_15545 ENOG4105ZTC transcriptional activator, Ogr delta GPJ68_15585 ENOG4105UZW Tail fiber assembly protein GPJ68_15590 ENOG410685N tail fiber protein GPJ68_15685 ENOG4105ED4 portal protein GPJ68_15700 ENOG4105VZ1 Replication Protein GPJ68_15745 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPJ68_15750 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPJ68_15755 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) GPJ68_15760 ENOG4105VEQ Cold shock protein GPJ68_15770 ENOG4105DJY efflux transporter, rnd family, mfp subunit GPJ68_15775 ENOG4108MJ5 VirK protein GPJ68_15780 ENOG4105CPB ATP-dependent endonuclease of the OLD family GPJ68_15785 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPJ68_15790 ENOG4105DWU Membrane GPJ68_15800 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPJ68_15805 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain GPJ68_15815 ENOG4105C7K acetolactate synthase GPJ68_15820 ENOG4105C5W Aldolase GPJ68_15825 ENOG4105CGD Nad-dependent epimerase dehydratase GPJ68_15830 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase GPJ68_15835 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase GPJ68_15845 ENOG41064MM (LipO)protein GPJ68_15850 ENOG4105E5Z arginine transporter ATP-binding subunit GPJ68_15855 ENOG4106PMH Extracellular solute-binding protein family 3 GPJ68_15860 ENOG4105GBT ABC transporter GPJ68_15865 ENOG4105DMR ABC, transporter GPJ68_15870 ENOG4106TNF Periplasmic binding protein GPJ68_15875 ENOG4107TE5 Lipid kinase GPJ68_15880 ENOG4105EIE fructose-bisphosphate aldolase GPJ68_15890 ENOG4105EAA nucleoside GPJ68_15895 ENOG4108KD5 ADP-ribosylation crystallin J1 GPJ68_15900 ENOG4108TFM Kinase, PfkB family GPJ68_15905 ENOG4105FDP GntR family transcriptional regulator GPJ68_15910 ENOG4105DWF phosphomethylpyrimidine kinase GPJ68_15915 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase GPJ68_15925 ENOG4105F9F transposase GPJ68_15990 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly GPJ68_16000 ENOG4105CW0 outer membrane usher protein GPJ68_16005 ENOG4108MQF Chaperone GPJ68_16020 ENOG4105D1F ATP-binding protein GPJ68_16030 ENOG4108YCW (LipO)protein GPJ68_16035 ENOG4108W15 Protein of unknown function (DUF1456) GPJ68_16045 ENOG4108HRK Histidine kinase GPJ68_16050 ENOG4108XDN Transcriptional regulator GPJ68_16060 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component GPJ68_16065 ENOG4108IJ8 ABC transporter GPJ68_16070 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component GPJ68_16075 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system GPJ68_16080 ENOG4107QK4 glycoside hydrolase, family 3 domain protein GPJ68_16085 ENOG4105CXG d-lactate dehydrogenase GPJ68_16090 ENOG41061WM D-Alanyl-D-Alanine GPJ68_16095 ENOG41069YE inner membrane protein yohC GPJ68_16100 ENOG4105KHU inner membrane protein YohD GPJ68_16105 ENOG4105ETP RND efflux system, outer membrane lipoprotein GPJ68_16110 ENOG4105F2I Transposase GPJ68_16115 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_16145 ENOG4105K89 arsenate reductase GPJ68_16165 ENOG4108YXQ IS66 Orf2 family protein GPJ68_16175 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GPJ68_16185 ENOG4108SF5 RNA Polymerase GPJ68_16190 ENOG4108S3W Anti-feci sigma factor, fecr GPJ68_16195 ENOG4105GAV receptor GPJ68_16200 ENOG4108HUF Transporter GPJ68_16205 ENOG4105DQ5 transport system permease protein GPJ68_16210 ENOG4108IHU transport system permease protein GPJ68_16215 ENOG4105E0A ABC, transporter GPJ68_16220 ENOG4108YXQ IS66 Orf2 family protein GPJ68_16235 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_16245 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) GPJ68_16250 ENOG4108UW5 maltose o-acetyltransferase GPJ68_16285 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) GPJ68_16290 ENOG4105MSY salicylate hydroxylase GPJ68_16295 ENOG4108RXX maleylacetoacetate isomerase GPJ68_16320 ENOG4105VAW lrga family GPJ68_16325 ENOG41067MG lrgb family GPJ68_16330 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) GPJ68_16335 ENOG4107GZ4 SanA protein GPJ68_16340 ENOG4105Y9N Membrane GPJ68_16345 ENOG4105BZ8 glutamate synthase GPJ68_16350 ENOG4107SJI Dehydrogenase GPJ68_16355 ENOG4107SDZ Galactoside transport system permease protein mglC GPJ68_16360 ENOG4105C2J ABC transporter GPJ68_16370 ENOG41060NJ transcriptional regulator GPJ68_16375 ENOG4105DHF Membrane GPJ68_16380 ENOG4105EUJ GTP cyclohydrolase i GPJ68_16390 ENOG4105D05 Receptor GPJ68_16395 ENOG4108IQI permease GPJ68_16400 ENOG4105DUM transcriptional regulator, lysR family GPJ68_16405 ENOG4105HMI Membrane GPJ68_16410 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GPJ68_16415 ENOG4105DD7 kinase (PfkB family GPJ68_16420 ENOG4105D9N nucleoside GPJ68_16425 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) GPJ68_16430 ENOG4105DD7 kinase (PfkB family GPJ68_16435 ENOG4107YNJ LysR family Transcriptional regulator GPJ68_16445 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPJ68_16450 ENOG4105DM4 PTS System GPJ68_16455 ENOG4105DE4 1-phosphofructokinase GPJ68_16460 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein GPJ68_16465 ENOG4105S8Q sugar efflux transporter GPJ68_16470 ENOG4105KRS Proteinase inhibitor GPJ68_16475 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GPJ68_16480 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) GPJ68_16485 ENOG4108EM1 reductase GPJ68_16490 ENOG4105CUW cytochrome C-TYPE protein GPJ68_16495 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GPJ68_16500 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GPJ68_16505 ENOG4105DEI Mannitol dehydrogenase GPJ68_16510 ENOG4105CKI cobalamin synthesis protein GPJ68_16515 ENOG41076MN Phosphoesterase, PA-phosphatase related GPJ68_16520 ENOG4107TT5 NLP P60 protein GPJ68_16540 ENOG4105E43 Extracellular solute-binding protein, family 5 GPJ68_16545 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component GPJ68_16550 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component GPJ68_16555 ENOG4108JQ5 ABC transporter GPJ68_16560 ENOG4105HG6 GPJ68_16565 ENOG4105C2C drug resistance transporter, Bcr CflA GPJ68_16570 ENOG4105I08 Pseudouridine synthase GPJ68_16575 ENOG4105CFI type iii restriction protein res subunit GPJ68_16580 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GPJ68_16585 ENOG4106V8H Nucleoid-associated protein GPJ68_16590 ENOG4105PAN UPF0352 protein GPJ68_16595 ENOG4105E68 Sulfatase GPJ68_16605 ENOG4105WH1 Two component transcriptional regulator luxr family GPJ68_16610 ENOG4105KWW Biogenesis protein GPJ68_16615 ENOG4107QX9 Thiol disulfide interChange protein GPJ68_16620 ENOG4105DA4 cytochrome c-type biogenesis protein GPJ68_16625 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) GPJ68_16630 ENOG4105X3C heme exporter protein GPJ68_16635 ENOG41060IM Heme exporter protein GPJ68_16640 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) GPJ68_16645 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) GPJ68_16650 ENOG4105CUW cytochrome C-TYPE protein GPJ68_16655 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) GPJ68_16660 ENOG4105GXZ Ferredoxin-type protein NapH GPJ68_16665 ENOG4108BGM Quinol dehydrogenase periplasmic component GPJ68_16670 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GPJ68_16675 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase GPJ68_16680 ENOG4108ZNS ferredoxin-type protein NapF GPJ68_16690 ENOG4105DWT malate dehydrogenase (quinone) GPJ68_16695 ENOG4105CHH sulfate transporter GPJ68_16700 ENOG4105CJW magnesium transporter GPJ68_16705 ENOG4105IBP Cyclic peptide transporter GPJ68_16710 ENOG4105CF1 Alkylated DNA repair protein GPJ68_16715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GPJ68_16720 ENOG4105CJ2 (LipO)protein GPJ68_16725 ENOG4105FCK Membrane GPJ68_16735 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC GPJ68_16740 ENOG41068CG regulatoR GPJ68_16745 ENOG4105BZU Histidine kinase GPJ68_16750 ENOG4105BZU Histidine kinase GPJ68_16755 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPJ68_16760 ENOG4107QP7 CoA-transferase subunit A GPJ68_16765 ENOG4107QNJ CoA-transferase subunit B GPJ68_16770 ENOG4105CRW Short chain fatty acid transporter GPJ68_16775 ENOG4105CHU acetyl-coa acetyltransferase GPJ68_16780 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPJ68_16785 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GPJ68_16790 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPJ68_16795 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPJ68_16800 ENOG4105XPH Ferredoxin GPJ68_16805 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase GPJ68_16810 ENOG4105CXY transporter GPJ68_16815 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A GPJ68_16820 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B GPJ68_16825 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GPJ68_16845 ENOG4105CSP Major Facilitator Superfamily GPJ68_16855 ENOG4107258 Transcriptional regulator GPJ68_16860 ENOG4108EWA cinA-like protein GPJ68_16865 ENOG4108UII YfaZ family GPJ68_16910 ENOG4106GZG polymyxin resistance protein B GPJ68_16915 ENOG4105CEY Amp-dependent synthetase and ligase GPJ68_16920 ENOG4105DNI Converts SHCHC to OSB (By similarity) GPJ68_16925 ENOG4108IPT Naphthoate synthase GPJ68_16930 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GPJ68_16940 ENOG4105E4F Isochorismate synthase GPJ68_16945 ENOG4105TNS Conserved Protein GPJ68_16950 ENOG4107YB6 acetyltransferase, (GNAT) family GPJ68_16955 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GPJ68_16965 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GPJ68_16970 ENOG4105C8S subunit m GPJ68_16975 ENOG4105D65 subunit l GPJ68_16985 ENOG4107UFS subunit j GPJ68_16995 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) GPJ68_17000 ENOG4108IEH NADH dehydrogenase subunit g GPJ68_17005 ENOG4107QIZ NADH dehydrogenase GPJ68_17010 ENOG4105GKE subunit e GPJ68_17015 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GPJ68_17020 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GPJ68_17030 ENOG4107NQ8 LysR family Transcriptional regulator GPJ68_17040 ENOG4105CHM Aminotransferase GPJ68_17045 ENOG4105DK2 UPF0207 protein GPJ68_17050 ENOG4107QWE )-transporter GPJ68_17055 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 GPJ68_17065 ENOG4105PQ6 UPF0208 membrane protein GPJ68_17070 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GPJ68_17075 ENOG4105C6K Malic enzyme GPJ68_17080 ENOG4105CSX c4-dicarboxylate anaerobic carrier GPJ68_17085 ENOG4105PTV Nudix Hydrolase GPJ68_17090 ENOG4108RE9 Phosphodiesterase GPJ68_17095 ENOG4108SHQ Glutathione S-transferase GPJ68_17100 ENOG4105CYM Glutathione S-transferase GPJ68_17105 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase GPJ68_17110 ENOG4105ECP epimerase GPJ68_17115 ENOG4105D9U N-acetyltransferase GPJ68_17120 ENOG4108JEH abc transporter atp-binding protein GPJ68_17125 ENOG4106YG3 ABC transporter GPJ68_17130 ENOG4105DSP amino acid AbC transporter GPJ68_17135 ENOG4105E89 ABC transporter GPJ68_17140 ENOG4105E89 ABC transporter GPJ68_17145 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GPJ68_17150 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase GPJ68_17155 ENOG4105E96 Colicin v production protein GPJ68_17160 ENOG4108S3P Sporulation domain protein GPJ68_17165 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GPJ68_17175 ENOG4105DQR SNARE associated Golgi GPJ68_17185 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GPJ68_17190 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) GPJ68_17195 ENOG4106WZ1 flagella biosynthesis regulator GPJ68_17200 ENOG4105F9N Major Facilitator Superfamily GPJ68_17225 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GPJ68_17230 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) GPJ68_17235 ENOG4105MH2 YfcL protein GPJ68_17240 ENOG4108BPE -transporting atpase GPJ68_17245 ENOG4105EJ9 Membrane GPJ68_17250 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) GPJ68_17260 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) GPJ68_17265 ENOG4108DG9 Smr protein MutS2 GPJ68_17270 ENOG4108BY2 phosphohistidine phosphatase GPJ68_17275 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPJ68_17280 ENOG4105CHU acetyl-coa acetyltransferase GPJ68_17285 ENOG4105KZW UPF0381 protein GPJ68_17290 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation GPJ68_17295 ENOG410903C (LipO)protein GPJ68_17300 ENOG4105S64 Formate nitrite transporter GPJ68_17320 ENOG4105KZM cytoplasmic protein GPJ68_17325 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_17330 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme GPJ68_17335 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta GPJ68_17345 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC GPJ68_17350 ENOG4105CXY transporter GPJ68_17355 ENOG4105W9M Membrane GPJ68_17360 ENOG4105D1S lipid A biosynthesis GPJ68_17370 ENOG4108BUD transposase GPJ68_17380 ENOG4105CHM Aminotransferase GPJ68_17385 ENOG4108HRK Histidine kinase GPJ68_17390 ENOG4105DY9 regulatoR GPJ68_17395 ENOG4108CIP transcriptional regulator GPJ68_17405 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GPJ68_17410 ENOG4105CN9 Peptidase m42 family protein GPJ68_17415 ENOG4105DC7 peptidase M24 GPJ68_17420 ENOG410863U PTS System GPJ68_17425 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) GPJ68_17430 ENOG4105CHC glucokinase (EC 2.7.1.2) GPJ68_17440 ENOG4107RA9 decarboxylase GPJ68_17445 ENOG4105CPC Aldo Keto reductase GPJ68_17450 ENOG4109076 Conserved Protein GPJ68_17455 ENOG4105CI1 PTS System GPJ68_17460 ENOG4105C83 adenylosuccinate lyase GPJ68_17465 ENOG4105CE4 GlcNAc 6-P deacetylase GPJ68_17475 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GPJ68_17480 ENOG4105D9N nucleoside GPJ68_17495 ENOG4105HZG regulatoR GPJ68_17500 ENOG4105GXM Putative transcription regulator (DUF1323) GPJ68_17505 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GPJ68_17540 ENOG4108M0I Transcriptional regulator GPJ68_17545 ENOG4105DHU Bile acid GPJ68_17550 ENOG4105VRT cytoplasmic protein GPJ68_17555 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GPJ68_17570 ENOG4105C6T cysteine synthase GPJ68_17575 ENOG4105KZ7 phosphocarrier protein hpr GPJ68_17585 ENOG4105C5Y PTS System GPJ68_17595 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) GPJ68_17600 ENOG4105CSW GntR family transcriptional regulator GPJ68_17605 ENOG41089BK Glutamine amido-transferase GPJ68_17610 ENOG4105C6T cysteine synthase GPJ68_17615 ENOG4108IJ6 ABC transporter GPJ68_17620 ENOG4105ECW sulfate abc transporter GPJ68_17625 ENOG4108I5D sulfate abc transporter GPJ68_17630 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein GPJ68_17635 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GPJ68_17640 ENOG4105JXH GntR family transcriptional regulator GPJ68_17645 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPJ68_17650 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPJ68_17655 ENOG4105CH7 arginosuccinase GPJ68_17660 ENOG4105EZR dyp-type peroxidase family protein GPJ68_17665 ENOG4105E7K (LipO)protein GPJ68_17670 ENOG4105QZU Inner membrane protein YfeZ GPJ68_17675 ENOG4108R6G acetyltransferase GPJ68_17680 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase GPJ68_17690 ENOG4108K3Z AraC family transcriptional regulator GPJ68_17695 ENOG4108X49 Ethanolamine utilization protein EutK GPJ68_17700 ENOG4106D67 ethanolamine utilization protein GPJ68_17710 ENOG4105CPD ethanolamine ammonia-lyase GPJ68_17715 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase GPJ68_17720 ENOG4105ENY Ethanolamine utilization protein eutH GPJ68_17725 ENOG4105C0A alcohol dehydrogenase GPJ68_17730 ENOG4107YMV ethanolamine utilization protein GPJ68_17735 ENOG4108EKI Dehydrogenase GPJ68_17740 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml GPJ68_17745 ENOG4105KNY Microcompartments protein GPJ68_17750 ENOG4108IJ2 phosphate acetyltransferase GPJ68_17755 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase GPJ68_17760 ENOG4105NDK ethanolamine utilization protein GPJ68_17765 ENOG4106S4J ethanolamine utilization protein EutP GPJ68_17770 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place GPJ68_17775 ENOG4105C6K Malic enzyme GPJ68_17780 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPJ68_17785 ENOG4108PVD exported protein GPJ68_17795 ENOG4105BZ8 glutamate synthase GPJ68_17800 ENOG4105BZU Histidine kinase GPJ68_17805 ENOG4105BZS acriflavin resistance protein GPJ68_17815 ENOG4105KUZ arsenate reductase GPJ68_17820 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) GPJ68_17830 ENOG4106KED esterase YpfH GPJ68_17835 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) GPJ68_17840 ENOG4105CGZ zinc metallopeptidase GPJ68_17850 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPJ68_17860 ENOG4105RH4 Glycine cleavage system transcriptional repressor GPJ68_17865 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GPJ68_17870 ENOG4105DYB Isoaspartyl dipeptidase GPJ68_17875 ENOG4108P2H Inner membrane protein YjiG GPJ68_17880 ENOG41074DU domain protein GPJ68_17885 ENOG4105C02 permease GPJ68_17890 ENOG4105ERG peptidase m48, ste24p GPJ68_17895 ENOG4105K89 arsenate reductase GPJ68_17900 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) GPJ68_17905 ENOG4105C2W permease GPJ68_17910 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GPJ68_17915 ENOG4105CS2 ec 3.2.1.21 GPJ68_17925 ENOG4108V3E phosphoribosylglycinamide formyltransferase GPJ68_17930 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GPJ68_17935 ENOG4105C9X ppx gppa phosphatase GPJ68_17940 ENOG4105BZU Histidine kinase GPJ68_17945 ENOG41062G3 Protein of unknown function (DUF2633) GPJ68_17955 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GPJ68_17960 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GPJ68_17965 ENOG4105VPD cellular component movement GPJ68_17975 ENOG4105DUX Transporter GPJ68_17980 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GPJ68_17985 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPJ68_17990 ENOG4105N21 Membrane GPJ68_18000 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GPJ68_18010 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GPJ68_18020 ENOG4108JQB penicillin-binding protein 1C GPJ68_18025 ENOG4105DN3 alpha-2-macroglobulin domain protein GPJ68_18030 ENOG4105KHC sulfurtransferase GPJ68_18035 ENOG4105CI1 PTS System GPJ68_18045 ENOG4108Q3X Transcriptional regulator GPJ68_18050 ENOG4105YYA enhanced serine sensitivity protein SseB GPJ68_18055 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GPJ68_18060 ENOG4105WVQ Fe-S assembly protein IscX GPJ68_18065 ENOG4108ZIT Ferredoxin, 2FE-2S GPJ68_18080 ENOG4108Z4V iron-sulfur cluster assembly GPJ68_18085 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins GPJ68_18095 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family GPJ68_18100 ENOG4105CVS RNA methyltransferase TrmH family, group 1 GPJ68_18105 ENOG4105ECY inositol monophosphatase GPJ68_18110 ENOG4105D7X high-affinity nickel-transporter GPJ68_18115 ENOG41065CD Exported protein GPJ68_18125 ENOG4105C2J ABC transporter GPJ68_18130 ENOG4105CNN ABC, transporter GPJ68_18140 ENOG4105EF1 ribulokinase GPJ68_18145 ENOG4105C2X Arabinose 5-phosphate isomerase GPJ68_18150 ENOG4108MN2 Stationary phase inducible protein CsiE GPJ68_18155 ENOG4105D8G Major Facilitator superfamily GPJ68_18160 ENOG4105Q10 Fimbrial-like protein GPJ68_18165 ENOG4108VCD Chaperone GPJ68_18170 ENOG4105CW0 outer membrane usher protein GPJ68_18175 ENOG4105I74 Fimbrial protein GPJ68_18180 ENOG4108W5M transcriptional regulator GPJ68_18185 ENOG4105FUY alpha subunit GPJ68_18210 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GPJ68_18215 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GPJ68_18220 ENOG4108YZA Nitrogen regulatory protein pii GPJ68_18225 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPJ68_18230 ENOG4108SKK alpha helix protein GPJ68_18235 ENOG4107WP9 Histidine kinase GPJ68_18245 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) GPJ68_18250 ENOG4108Z6B deaminase GPJ68_18255 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB GPJ68_18265 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GPJ68_18270 ENOG4106G6Q Transcriptional regulator GPJ68_18275 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding GPJ68_18280 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GPJ68_18285 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) GPJ68_18295 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GPJ68_18305 ENOG4105C3F Signal peptidase i GPJ68_18315 ENOG4105WMJ Positive regulator of sigma E, RseC MucC GPJ68_18320 ENOG4105VQK sigma E regulatory protein, MucB RseB GPJ68_18330 ENOG4105EMN RNA polymerase sigma factor GPJ68_18340 ENOG4108IYU L-aspartate oxidase GPJ68_18350 ENOG4105C1J atp-dependent rna helicase GPJ68_18365 ENOG4105EIB trna rrna methyltransferase GPJ68_18370 ENOG4105K63 Thioredoxin GPJ68_18375 ENOG4106IUH DTW domain containing protein GPJ68_18380 ENOG4105CD5 CoA-binding domain protein GPJ68_18385 ENOG4105JIM Phosphatidylserine synthase GPJ68_18390 ENOG4105T42 (LipO)protein GPJ68_18395 ENOG4105CSH Transporter GPJ68_18420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit GPJ68_18425 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GPJ68_18430 ENOG4105C34 Pseudouridine synthase GPJ68_18435 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane GPJ68_18440 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA GPJ68_18450 ENOG4105CQC Prephenate dehydratase GPJ68_18455 ENOG4105EHE chorismate mutase- prephenate dehydrogenase GPJ68_18460 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) GPJ68_18465 ENOG4105QP9 Protein of unknown function (DUF2799) GPJ68_18470 ENOG4108WS1 GPJ68_18475 ENOG4108KHX Diguanylate cyclase GPJ68_18480 ENOG41090EK ompa motb domain protein GPJ68_18485 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GPJ68_18495 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GPJ68_18500 ENOG4105K5M 30s ribosomal protein S16 GPJ68_18505 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY GPJ68_18510 ENOG4106KVJ cytochrome C assembly protein GPJ68_18515 ENOG4108JU6 CBS domain protein GPJ68_18530 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GPJ68_18535 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) GPJ68_18540 ENOG4105VDB UPF0125 protein GPJ68_18545 ENOG4108Z1B Cyclase dehydrase GPJ68_18565 ENOG4105BZ1 (ABC) transporter GPJ68_18580 ENOG4105DFP Integrase GPJ68_18610 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GPJ68_18635 ENOG410679B prophage CP4-57 regulatory protein alpA GPJ68_18640 ENOG4108P8R GPJ68_18645 ENOG4105H5P transposase GPJ68_18670 ENOG4106H6R UPF0380 protein GPJ68_18680 ENOG4105ZTC transcriptional activator, Ogr delta GPJ68_18720 ENOG4105MEV Acyl-transferase GPJ68_18725 ENOG4105UZW Tail fiber assembly protein GPJ68_18815 ENOG4105ED4 portal protein GPJ68_18855 ENOG4105DFE Dna adenine methylase GPJ68_18860 ENOG4105KSC Transcriptional regulator, TraR DksA family GPJ68_18895 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPJ68_18910 ENOG4105C87 Aminotransferase class I and II GPJ68_18915 ENOG4107B2H carbonic anhydrase GPJ68_18925 ENOG4105CMR udp-glucose 4-epimerase GPJ68_18940 ENOG4107RA4 Glycosyl transferase (Group 1 GPJ68_18945 ENOG41088YS Glycosyl transferase (Group 1 GPJ68_19000 ENOG4108NAE Fimbrial chaperone protein GPJ68_19005 ENOG4105CW0 outer membrane usher protein GPJ68_19015 ENOG4105DHQ Histidine kinase GPJ68_19045 ENOG4105CHR reductase GPJ68_19050 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_19065 ENOG4105EAA nucleoside GPJ68_19090 ENOG4105D5U fad dependent oxidoreductase GPJ68_19095 ENOG4105C26 Dehydrogenase GPJ68_19100 ENOG4108JPW Aminotransferase GPJ68_19105 ENOG4105C85 amino acid GPJ68_19110 ENOG4108PVQ transcriptional regulator GPJ68_19115 ENOG4109066 lysm domain bon superfamily protein GPJ68_19120 ENOG4105VPI YqaE family transport protein GPJ68_19125 ENOG41080HT Transcriptional regulator, arsr family GPJ68_19130 ENOG4108V62 Rhodanese domain protein GPJ68_19140 ENOG4108X73 DNA- binding protein GPJ68_19145 ENOG4108RNS Exports L-alanine (By similarity) GPJ68_19150 ENOG4108WMJ Protein of unknown function (DUF2002) GPJ68_19160 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GPJ68_19165 ENOG4105WAZ (Glutaredoxin-like protein) NrdH GPJ68_19170 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GPJ68_19180 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GPJ68_19185 ENOG4108IJ7 Glycine betaine GPJ68_19190 ENOG4108HQS Glycine betaine GPJ68_19195 ENOG4105GIJ Glycine betaine GPJ68_19205 ENOG4108UMN azlc family GPJ68_19210 ENOG4105ZED uncharacterized protein ygaH GPJ68_19215 ENOG4105NTK Transcriptional repressor Mpra GPJ68_19220 ENOG4105CW7 secretion protein, HlyD family GPJ68_19225 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPJ68_19230 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GPJ68_19240 ENOG4105W39 Membrane GPJ68_19245 ENOG4107VXZ Hydrolase GPJ68_19275 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GPJ68_19280 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GPJ68_19290 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) GPJ68_19295 ENOG4107TH8 cina domain protein GPJ68_19300 ENOG4105CVE Lytic murein transglycosylase GPJ68_19305 ENOG410787A Pts system, glucitol sorbitol-specific GPJ68_19310 ENOG4105DZY Pts system, glucitol sorbitol-specific GPJ68_19315 ENOG4105VI0 Pts system, glucitol sorbitol-specific GPJ68_19320 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase GPJ68_19325 ENOG4105J92 DNA-binding transcriptional activator GutM GPJ68_19330 ENOG410804X Transcriptional regulator GPJ68_19335 ENOG4105C2X Arabinose 5-phosphate isomerase GPJ68_19340 ENOG4108JUA Transcriptional regulator GPJ68_19345 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center GPJ68_19350 ENOG4107QZF nitrite reductase NADPH large subunit GPJ68_19355 ENOG4105C8H hydrogenase maturation protein Hypf GPJ68_19360 ENOG4108RC0 Electron transport protein GPJ68_19365 ENOG4105DDV Transcriptional regulator (LacI family GPJ68_19370 ENOG4105C5Y PTS System GPJ68_19375 ENOG4105CS2 ec 3.2.1.21 GPJ68_19390 ENOG4108MG9 hydrogenase 3 maturation protease GPJ68_19395 ENOG4105I6X formate hydrogenlyase maturation GPJ68_19400 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit GPJ68_19405 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit GPJ68_19410 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GPJ68_19415 ENOG4107TDF Formate hydrogenlyase subunit 4 GPJ68_19420 ENOG4107R30 NADH dehydrogenase GPJ68_19425 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) GPJ68_19430 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA GPJ68_19435 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GPJ68_19440 ENOG4107RSS Hydrogenase accessory protein HypB GPJ68_19445 ENOG41083WG hydrogenase assembly chaperone GPJ68_19450 ENOG4105CQS hydrogenase expression formation protein HypD GPJ68_19455 ENOG4105C45 hydrogenase expression formation protein (HypE) GPJ68_19465 ENOG4105VXR cytoplasmic protein GPJ68_19475 ENOG4105DIK (ABC) transporter GPJ68_19480 ENOG4105CC5 ABC transporter GPJ68_19485 ENOG4105CC5 ABC transporter GPJ68_19490 ENOG4105BZU Histidine kinase GPJ68_19520 ENOG4105CW0 outer membrane usher protein GPJ68_19535 ENOG4105DHT Metal Dependent Phosphohydrolase GPJ68_19550 ENOG4105DS0 Transcriptional regulator, Crp Fnr family GPJ68_19560 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GPJ68_19570 ENOG4108K5P (LipO)protein GPJ68_19575 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) GPJ68_19580 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) GPJ68_19585 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) GPJ68_19600 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) GPJ68_19605 ENOG4105N0Z inner membrane protein ygbE GPJ68_19615 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) GPJ68_19625 ENOG4108MXK alkaline phosphatase isozyme conversion GPJ68_19630 ENOG4105PWE CRISPR-associated protein cas2 GPJ68_19635 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) GPJ68_19650 ENOG41060M0 Crispr-associated protein, cse4 family GPJ68_19665 ENOG4105DTT CRISPR-associated helicase, cas3 GPJ68_19685 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GPJ68_19690 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase GPJ68_19695 ENOG4105WQV ferredoxin-like protein GPJ68_19700 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GPJ68_19705 ENOG4105YBM electron transfer flavoprotein subunit ygcQ GPJ68_19710 ENOG4106IKH Electron transfer flavoprotein GPJ68_19715 ENOG4105C54 Major Facilitator superfamily GPJ68_19720 ENOG4107R3A FAD linked oxidase domain protein GPJ68_19725 ENOG4105CHR reductase GPJ68_19730 ENOG4108ITV Inner membrane protein yqcE GPJ68_19735 ENOG4108CWB sugar kinase ygcE GPJ68_19740 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GPJ68_19745 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) GPJ68_19755 ENOG4105QEK Transcriptional regulator GPJ68_19775 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GPJ68_19780 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GPJ68_19785 ENOG4105BZU Histidine kinase GPJ68_19790 ENOG4105BZW Glycerate kinase GPJ68_19795 ENOG4105EQX glucarate dehydratase GPJ68_19800 ENOG4105EQX glucarate dehydratase GPJ68_19805 ENOG4105DJB Major Facilitator Superfamily GPJ68_19810 ENOG4105QDK Flavodoxin GPJ68_19815 ENOG4105DR9 pseudouridine synthase GPJ68_19820 ENOG4105WP7 tRNA pseudouridine synthase C GPJ68_19825 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) GPJ68_19830 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GPJ68_19835 ENOG4105EWT decarboxylase family GPJ68_19840 ENOG4105C44 Serine transporter GPJ68_19845 ENOG4105EJQ L-serine dehydratase GPJ68_19850 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease GPJ68_19855 ENOG4105C0A alcohol dehydrogenase GPJ68_19860 ENOG4107W7X Aldolase GPJ68_19870 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GPJ68_19880 ENOG4105CNN ABC, transporter GPJ68_19885 ENOG4105C2J ABC transporter GPJ68_19890 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) GPJ68_19895 ENOG4105CMG Carbohydrate kinase GPJ68_19905 ENOG4107EDW L-fucose operon activator GPJ68_19910 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) GPJ68_19915 ENOG4105M08 Membrane GPJ68_19920 ENOG4105ETT transcriptional Regulator, LysR family GPJ68_19925 ENOG4105M5B (LipO)protein GPJ68_19930 ENOG4105C9B Cysteine desulfurase GPJ68_19935 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) GPJ68_19940 ENOG4105CUZ uba thif-type nad fad binding protein GPJ68_19945 ENOG4105CA3 membrane-bound lytic murein transglycosylase GPJ68_19960 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GPJ68_19965 ENOG4108EKC n-acetylglutamate synthase GPJ68_19970 ENOG4107QYX exodeoxyribonuclease v alpha GPJ68_19975 ENOG4107QKA exodeoxyribonuclease V beta GPJ68_19980 ENOG4107QXK peptidase GPJ68_19985 ENOG4105DSY exodeoxyribonuclease V, gamma GPJ68_19990 ENOG4105RVB Prepilin peptidase dependent protein c GPJ68_19995 ENOG4105SEN Protein of unknown function (DUF2509) GPJ68_20000 ENOG4105JCS prepilin peptidase dependent protein GPJ68_20005 ENOG4105IPU prepilin peptidase dependent protein A GPJ68_20020 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase GPJ68_20035 ENOG4105EE5 Membrane protein terC GPJ68_20040 ENOG4105SUV lipoprotein YgdR GPJ68_20045 ENOG4105CPC Aldo Keto reductase GPJ68_20050 ENOG4107S74 Lysophospholipid transporter LplT GPJ68_20065 ENOG4105DDV Transcriptional regulator (LacI family GPJ68_20075 ENOG4105RQF LysR family Transcriptional regulator GPJ68_20090 ENOG4105CHR reductase GPJ68_20100 ENOG4105CHU acetyl-coa acetyltransferase GPJ68_20105 ENOG4105C5Q Transcriptional regulator GPJ68_20115 ENOG4108MHD transport protein GPJ68_20125 ENOG41061MD high-affinity nickel-transporter GPJ68_20130 ENOG4105DZC cytosine deaminase GPJ68_20135 ENOG4105C5B carbamate kinase GPJ68_20145 ENOG4107REC cytoplasmic protein GPJ68_20150 ENOG4107R1Q Membrane protein FdrA GPJ68_20155 ENOG4105N16 Protein of unknown function (DUF2877) GPJ68_20160 ENOG4107SNB ankyrin repeat protein YahD GPJ68_20205 ENOG4105CAU Arsenical resistance protein, ArsH GPJ68_20230 ENOG4108YXQ IS66 Orf2 family protein GPJ68_20280 ENOG4105DFP Integrase GPJ68_20290 ENOG4108K5P (LipO)protein GPJ68_20300 ENOG4105CRK lysyL-tRNA synthetase GPJ68_20310 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GPJ68_20315 ENOG4105T95 Thiol disulfide interChange protein GPJ68_20320 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPJ68_20325 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) GPJ68_20330 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB GPJ68_20335 ENOG4105Y75 tpr repeat protein GPJ68_20345 ENOG4108UT2 hemolysin iii GPJ68_20355 ENOG4108Q3X Transcriptional regulator GPJ68_20360 ENOG4105CS2 ec 3.2.1.21 GPJ68_20365 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GPJ68_20370 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GPJ68_20385 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family GPJ68_20390 ENOG4105D0A hydroxylase GPJ68_20395 ENOG4107RAQ aminopeptidase GPJ68_20405 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) GPJ68_20415 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GPJ68_20420 ENOG4108JQ1 Dehydrogenase GPJ68_20430 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) GPJ68_20435 ENOG4105D5P Methylmalonyl-coA mutase GPJ68_20440 ENOG4105DJT lAO AO transport system ATPase GPJ68_20445 ENOG4108M7F enoyl-CoA hydratase isomerase GPJ68_20450 ENOG4105CYC Transferase GPJ68_20455 ENOG4105DEQ transcriptional regulator GPJ68_20460 ENOG4105MPN Membrane GPJ68_20475 ENOG4105D64 Mechanosensitive ion channel GPJ68_20480 ENOG4105D2N Aldolase GPJ68_20485 ENOG4105BZA Phosphoglycerate kinase GPJ68_20490 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GPJ68_20495 ENOG4107Z1W Fructose transport system kinase GPJ68_20500 ENOG4108R4K DNA-binding, transcriptional regulator GPJ68_20505 ENOG4108Q8A Fructose-1,6-bisphosphatase GPJ68_20510 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein GPJ68_20515 ENOG4105CTS PTS system mannitol-specific GPJ68_20520 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia GPJ68_20525 ENOG4105CV1 Transketolase (EC 2.2.1.1) GPJ68_20530 ENOG4108K0D peptidase, M48 GPJ68_20540 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) GPJ68_20550 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GPJ68_20555 ENOG4107QNK )-transporter GPJ68_20560 ENOG4105GPY SprT protein GPJ68_20565 ENOG4105RWS endonuclease I GPJ68_20570 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GPJ68_20575 ENOG4105D7Z glutathione synthase GPJ68_20580 ENOG4108UJU UPF0301 protein GPJ68_20585 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GPJ68_20590 ENOG4105CZX twitching motility protein GPJ68_20610 ENOG4105DFA alanine racemase domain protein GPJ68_20615 ENOG4108VIA integral membrane protein GPJ68_20620 ENOG4105VZ9 UPF0235 protein GPJ68_20630 ENOG4105CSA Coproporphyrinogen iii oxidase GPJ68_20640 ENOG4105HDK L-asparaginase GPJ68_20645 ENOG4105K33 Periplasmic Protein GPJ68_20650 ENOG41090ED Protein with unknown function (DUF469) GPJ68_20660 ENOG4105CEN a g-specific adenine glycosylase GPJ68_20665 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) GPJ68_20670 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division GPJ68_20675 ENOG4105EAA nucleoside GPJ68_20680 ENOG4105CXN decarboxylase GPJ68_20685 ENOG4108UQV Membrane GPJ68_20745 ENOG4105DQ6 Transposase GPJ68_20750 ENOG4108YXQ IS66 Orf2 family protein GPJ68_20760 ENOG4105E5H Transposase GPJ68_20765 ENOG4108YXQ IS66 Orf2 family protein GPJ68_20835 ENOG4108T1W Fimbrial subunit type 3 GPJ68_20875 ENOG4108MXD gtp-binding protein GPJ68_20890 ENOG4106ZN7 UPF0401 protein YkfF GPJ68_20895 ENOG4106H6R UPF0380 protein GPJ68_20900 ENOG4106549 Antirestriction protein GPJ68_20905 ENOG4108XS9 dna repair protein GPJ68_20910 ENOG4105ZS6 Protein of unknown function (DUF987) GPJ68_20915 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles GPJ68_20980 ENOG4106032 Glutathionylspermidine synthase GPJ68_20985 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit GPJ68_20990 ENOG4105CYM Glutathione S-transferase GPJ68_20995 ENOG41082MF Hydrogenase assembly chaperone hypC hupF GPJ68_21000 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) GPJ68_21005 ENOG4108WGS hydrogenase 2-specific chaperone GPJ68_21010 ENOG4108USZ hydrogenase GPJ68_21015 ENOG4105DPX Hydrogenase, large subunit GPJ68_21020 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit GPJ68_21025 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPJ68_21030 ENOG4105E3S small subunit GPJ68_21035 ENOG410900S Protein of unknown function (DUF2623) GPJ68_21040 ENOG4105C8Q Methyl-accepting chemotaxis GPJ68_21050 ENOG4105CPC Aldo Keto reductase GPJ68_21070 ENOG4108ZZF transport protein (ExbD) GPJ68_21075 ENOG4105CWK Biopolymer transport protein, ExbB GPJ68_21080 ENOG4105C28 cystathionine GPJ68_21085 ENOG4108K81 inner membrane protein YghB GPJ68_21090 ENOG4105CF7 AraC family transcriptional regulator GPJ68_21095 ENOG4108I6A alcohol dehydrogenase GPJ68_21100 ENOG4105CV8 reductase GPJ68_21110 ENOG4105CCT upf0313 protein GPJ68_21115 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPJ68_21120 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) GPJ68_21125 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase GPJ68_21130 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPJ68_21135 ENOG4105H4F exported protein GPJ68_21140 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPJ68_21145 ENOG4105DHQ Histidine kinase GPJ68_21150 ENOG4105NF4 modulator of drug activity GPJ68_21155 ENOG4105VRH Antibiotic biosynthesis monooxygenase GPJ68_21160 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GPJ68_21165 ENOG4105IPS esterase GPJ68_21170 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) GPJ68_21175 ENOG4108SX3 cytoplasmic protein GPJ68_21180 ENOG41087AY ADP-Ribose pyrophosphatase GPJ68_21190 ENOG4105F1G UPF0441 protein GPJ68_21195 ENOG4106032 Glutathionylspermidine synthase GPJ68_21200 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GPJ68_21215 ENOG4108MR7 Arylsulfotransferase GPJ68_21225 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) GPJ68_21235 ENOG4105W0Z cytoplasmic protein GPJ68_21245 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) GPJ68_21250 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) GPJ68_21255 ENOG4105I7R Adenylate cyclase GPJ68_21260 ENOG4106MWK domain protein GPJ68_21265 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate GPJ68_21270 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GPJ68_21275 ENOG4107ZVW dihydroneopterin aldolase GPJ68_21280 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GPJ68_21285 ENOG4105EJC lysr family transcriptional regulator GPJ68_21290 ENOG4106DSS Tartrate dehydratase subunit alpha GPJ68_21295 ENOG4107GFK fumarate GPJ68_21300 ENOG4107QPK )-transporter GPJ68_21305 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GPJ68_21310 ENOG4108YZ9 Urea amidohydrolase subunit gamma GPJ68_21315 ENOG4105KI2 Urea amidohydrolase subunit beta GPJ68_21320 ENOG4105CQM Urea amidohydrolase subunit alpha GPJ68_21325 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) GPJ68_21330 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) GPJ68_21335 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) GPJ68_21340 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GPJ68_21350 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GPJ68_21355 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPJ68_21370 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures GPJ68_21375 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles GPJ68_21380 ENOG4108XS9 dna repair protein GPJ68_21385 ENOG4106549 Antirestriction protein GPJ68_21390 ENOG4106ZN7 UPF0401 protein YkfF GPJ68_21395 ENOG4105F4K antigen 43 GPJ68_21400 ENOG4108KZE transcriptional regulator GPJ68_21405 ENOG4106H6R UPF0380 protein GPJ68_21410 ENOG4108MXD gtp-binding protein GPJ68_21425 ENOG4105C2X Arabinose 5-phosphate isomerase GPJ68_21430 ENOG4105ECX polysaccharide export GPJ68_21435 ENOG4107V1M polysaccharide export protein GPJ68_21440 ENOG4105E12 capsule polysaccharide GPJ68_21445 ENOG41084CK capsule polysaccharide GPJ68_21470 ENOG4105H5P transposase GPJ68_21475 ENOG4108P8R GPJ68_21495 ENOG4105MZU cell filamentation protein GPJ68_21505 ENOG4105V2F Uncharacterized protein yoac GPJ68_21510 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit GPJ68_21515 ENOG4108ZFT Dehydratase small subunit GPJ68_21520 ENOG4105YCI dehydratase medium subunit GPJ68_21565 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GPJ68_21575 ENOG4105Q26 Siderophore-interacting protein GPJ68_21580 ENOG4105NTW Transcriptional regulator GPJ68_21585 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor GPJ68_21590 ENOG4105C8Y Acetylornithine aminotransferase GPJ68_21595 ENOG4108Y51 tRNA-binding protein GPJ68_21600 ENOG4105CQ4 Transcriptional regulator GPJ68_21605 ENOG4105CNT hydrolase family 2 GPJ68_21610 ENOG4105FK9 beta-D-galactosidase beta subunit GPJ68_21620 ENOG4105HY2 Glycosidase related protein GPJ68_21630 ENOG4105DRS transport system, permease GPJ68_21635 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GPJ68_21660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GPJ68_21665 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) GPJ68_21670 ENOG4108VKG metal-dependent hydrolase GPJ68_21675 ENOG4105EE0 oxidoreductase GPJ68_21680 ENOG4105DU1 integral membrane protein, terc GPJ68_21695 ENOG4105CTX dehydratase GPJ68_21705 ENOG4105DPW Major facilitator superfamily MFS_1 GPJ68_21710 ENOG4107YCY Transcriptional regulator GPJ68_21715 ENOG4106W5V Membrane GPJ68_21725 ENOG4105WAY exported protein GPJ68_21730 ENOG4105NE1 Conserved Protein GPJ68_21735 ENOG41090KG Inner membrane protein YqjE GPJ68_21740 ENOG4105YJD GPJ68_21745 ENOG4108VBZ doxx family GPJ68_21750 ENOG4105CHF Glutathione S-transferase GPJ68_21755 ENOG4105KAF membrAne GPJ68_21760 ENOG4105CWB LysR family transcriptional Regulator GPJ68_21765 ENOG4108CNN domain protein GPJ68_21770 ENOG4106D80 Uncharacterized protein YhaL GPJ68_21810 ENOG4105I1F Resistance protein GPJ68_21820 ENOG4108BUD transposase GPJ68_21870 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GPJ68_21920 ENOG4105EJQ L-serine dehydratase GPJ68_21925 ENOG4105KME endoribonuclease L-psp GPJ68_21930 ENOG4105C6N Formate acetyltransferase GPJ68_21940 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) GPJ68_21945 ENOG4105C7B Threonine dehydratase GPJ68_21950 ENOG410811B TRANSCRIPTIONal GPJ68_21960 ENOG4105F9F transposase GPJ68_22000 ENOG4105BZW Glycerate kinase GPJ68_22005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPJ68_22010 ENOG4105CNV Aldolase GPJ68_22015 ENOG4105DJB Major Facilitator Superfamily GPJ68_22020 ENOG4105CTX dehydratase GPJ68_22025 ENOG4105E98 transcriptional regulator DeoR family GPJ68_22030 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GPJ68_22035 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB GPJ68_22045 ENOG4105F3R pts system mannose fructose sorbose family iid GPJ68_22050 ENOG4108YTN IIa component GPJ68_22055 ENOG4105CE4 GlcNAc 6-P deacetylase GPJ68_22060 ENOG4105E70 isomerase GPJ68_22065 ENOG4105D2N Aldolase GPJ68_22070 ENOG4105CI1 PTS System GPJ68_22075 ENOG4105C87 Aminotransferase class I and II GPJ68_22080 ENOG4108UZY PTS System GPJ68_22085 ENOG4105ETZ PTS System GPJ68_22090 ENOG4105F3R pts system mannose fructose sorbose family iid GPJ68_22100 ENOG4106HBN Galactosamine-6-phosphate isomerase GPJ68_22105 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GPJ68_22110 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) GPJ68_22120 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) GPJ68_22125 ENOG4105W4M Transport-associated protein GPJ68_22130 ENOG4105K4T epimerase GPJ68_22135 ENOG4108ZPB UPF0306 protein GPJ68_22140 ENOG41082IR Excinuclease ABC C subunit domain protein GPJ68_22145 ENOG4108YYD acetyltransferase GPJ68_22165 ENOG4105DEN Luciferase family GPJ68_22170 ENOG4105CIC tryptophan-specific transport protein GPJ68_22175 ENOG4105C1J atp-dependent rna helicase GPJ68_22205 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GPJ68_22210 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GPJ68_22215 ENOG4105CHV Transcription elongation factor NusA GPJ68_22220 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GPJ68_22230 ENOG4105CDH Citrulline--aspartate ligase GPJ68_22240 ENOG4105NTZ Preprotein translocase subunit SecG GPJ68_22245 ENOG4107YNJ LysR family Transcriptional regulator GPJ68_22250 ENOG4105DYB Isoaspartyl dipeptidase GPJ68_22255 ENOG4105CEE C4-dicarboxylate transporter GPJ68_22260 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GPJ68_22265 ENOG4105EEI dihydropteroate synthase GPJ68_22270 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GPJ68_22280 ENOG4105HBR Rna-binding protein GPJ68_22285 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GPJ68_22290 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase GPJ68_22295 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GPJ68_22300 ENOG4105QYV Membrane GPJ68_22305 ENOG4105K46 50S ribosomal protein l27 GPJ68_22310 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GPJ68_22315 ENOG4105EAH synthase GPJ68_22320 ENOG4105HVQ Regulatory factor of maltose metabolism GPJ68_22330 ENOG4105VFK BolA family GPJ68_22335 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane GPJ68_22340 ENOG4105E3I toluene tolerance GPJ68_22345 ENOG4107PE3 Mammalian cell entry related domain protein GPJ68_22350 ENOG4105CY3 ABC transporter, permease GPJ68_22355 ENOG4105DHJ ABC, transporter GPJ68_22360 ENOG4105FEU K -dependent Na -Ca exchanger GPJ68_22365 ENOG4105C2X Arabinose 5-phosphate isomerase GPJ68_22370 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase GPJ68_22375 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) GPJ68_22380 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA GPJ68_22385 ENOG4108IUZ ABC transporter GPJ68_22390 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GPJ68_22395 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA GPJ68_22400 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN GPJ68_22405 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GPJ68_22410 ENOG41080Z8 PHOSPHOCARRIER protein GPJ68_22415 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase GPJ68_22420 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain GPJ68_22425 ENOG4105BZU Histidine kinase GPJ68_22430 ENOG4105N5T Radical SAM Protein GPJ68_22435 ENOG4105CBC glutamate synthase GPJ68_22440 ENOG4105BZ8 glutamate synthase GPJ68_22445 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin GPJ68_22450 ENOG4105DZC cytosine deaminase GPJ68_22455 ENOG4108R66 Conserved Protein GPJ68_22460 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) GPJ68_22470 ENOG4105JHE Major Facilitator Superfamily GPJ68_22475 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GPJ68_22485 ENOG4105CEE C4-dicarboxylate transporter GPJ68_22490 ENOG4105KB2 stringent starvation protein b GPJ68_22495 ENOG4107MKT Stringent starvation protein a GPJ68_22505 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GPJ68_22510 ENOG4105D6Z AFG1 family ATPase GPJ68_22515 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III GPJ68_22520 ENOG4105C0H protease GPJ68_22525 ENOG4105C0H protease GPJ68_22535 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) GPJ68_22545 ENOG4105UNR (Barnase) inhibitor GPJ68_22550 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) GPJ68_22555 ENOG4105Y49 secretion protein, HlyD family GPJ68_22560 ENOG4105ZQC membrane protein AaeX GPJ68_22565 ENOG4105CR8 Transcriptional regulator GPJ68_22570 ENOG4105D1U peptidase U62 modulator of DNA gyrase GPJ68_22575 ENOG4105QD6 exported protein GPJ68_22580 ENOG4105C03 ribonuclease GPJ68_22590 ENOG4105VQ7 Rod shape-determining protein MreD GPJ68_22595 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GPJ68_22605 ENOG41062P1 Diguanylate cyclase phosphodiesterase GPJ68_22610 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family GPJ68_22625 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein GPJ68_22630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GPJ68_22635 ENOG4105RG0 Membrane GPJ68_22640 ENOG4108IA2 Sodium pantothenate symporter GPJ68_22650 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPJ68_22660 ENOG4105CEC DNA methylase N-4 N-6 GPJ68_22665 ENOG41061ME transport protein GPJ68_22670 ENOG4108XG4 DNA-binding transcriptional regulator GPJ68_22675 ENOG4105C1P efflux transporter, rnd family, mfp subunit GPJ68_22680 ENOG4105BZS acriflavin resistance protein GPJ68_22685 ENOG4105XCM membrane LIPOPROTEIN GPJ68_22695 ENOG4105EZ7 amino acid ABC transporter GPJ68_22700 ENOG4105DRP amino acid AbC transporter GPJ68_22705 ENOG4105CDA abc transporter atp-binding protein GPJ68_22740 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GPJ68_22745 ENOG4108MRH transcriptional regulatory protein GPJ68_22755 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GPJ68_22760 ENOG4107GFK fumarate GPJ68_22765 ENOG4108R5S membrane GPJ68_22770 ENOG4105W3H MtN3 and saliva related transmembrane protein GPJ68_22775 ENOG4105CT4 transporter GPJ68_22780 ENOG4105F8D glycoside hydrolase family 4 GPJ68_22785 ENOG4108K2B transcriptional regulator GPJ68_22790 ENOG4105CXN decarboxylase GPJ68_22795 ENOG4106ZGR Transcriptional regulator GPJ68_22800 ENOG4105D5Q Arginine ornithine antiporter GPJ68_22805 ENOG4105DIJ Phosphoethanolamine transferase GPJ68_22810 ENOG4105XJC Two component transcriptional regulator (Winged helix family GPJ68_22815 ENOG4105ECM Sensor protein basS pmrB GPJ68_22825 ENOG4105CSH Transporter GPJ68_22830 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GPJ68_22835 ENOG4108YIV GPJ68_22840 ENOG4108F5E vimentin GPJ68_22845 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GPJ68_22850 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase GPJ68_22855 ENOG4105D5T phosphonate abc transporter GPJ68_22860 ENOG4105EHI Phosphonate ABC transporter, periplasmic GPJ68_22870 ENOG4107RJJ Transcriptional regulator GPJ68_22875 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG GPJ68_22880 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH GPJ68_22885 ENOG4105EKV Phosphonate metabolism protein GPJ68_22890 ENOG4105FT8 Phosphonate metabolism GPJ68_22895 ENOG4105ENV phosphonate C-P lyase system protein PhnK GPJ68_22900 ENOG4105HRV phosphonate c-p lyase system protein phnl GPJ68_22905 ENOG4105FD8 phosphonate metabolism protein PhnM GPJ68_22910 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) GPJ68_22915 ENOG410849A acetyltransferase, (GNAT) family GPJ68_22920 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein GPJ68_22935 ENOG4105C2J ABC transporter GPJ68_22940 ENOG4105CNN ABC, transporter GPJ68_22945 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPJ68_22990 ENOG4105D2N Aldolase GPJ68_23010 ENOG41082ND Uncharacterized protein yjcO GPJ68_23015 ENOG4105CK2 sodium dicarboxylate symporter GPJ68_23020 ENOG4108W0S formate-dependent nitrite reductase complex GPJ68_23035 ENOG4105EQR Transposase IS116 IS110 IS902 GPJ68_23045 ENOG4105DVI reductase, NrfD GPJ68_23050 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPJ68_23055 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit GPJ68_23065 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GPJ68_23070 ENOG41062QD Membrane GPJ68_23075 ENOG4107QN1 sodium solute GPJ68_23080 ENOG41067MG lrgb family GPJ68_23090 ENOG4105CMU LysR family (Transcriptional regulator GPJ68_23095 ENOG4105EEQ Na H antiporter GPJ68_23100 ENOG4105C7N Xanthine uracil vitamin C permease GPJ68_23105 ENOG4108Z4X TRANSCRIPTIONal GPJ68_23110 ENOG4108W3Q Transcriptional regulator GPJ68_23115 ENOG4108M8H domain protein GPJ68_23120 ENOG4105PMV Membrane GPJ68_23125 ENOG4108UUM single-stranded DNA-binding protein GPJ68_23130 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GPJ68_23135 ENOG4105MSB protein, conserved in bacteria GPJ68_23140 ENOG4105F0S class B acid phosphatase GPJ68_23145 ENOG4105CGF Aromatic amino acid aminotransferase GPJ68_23155 ENOG4105CDU Replicative dna helicase GPJ68_23160 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GPJ68_23165 ENOG4105P4Z Phage shock protein G GPJ68_23170 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GPJ68_23180 ENOG4105MYN Zinc uptake regulation protein GPJ68_23185 ENOG4105VDW Csbd family GPJ68_23190 ENOG4107R73 Mate efflux family protein GPJ68_23200 ENOG41080IJ Diacylglycerol kinase GPJ68_23205 ENOG4105E55 glycerol-3-phosphate acyltransferase GPJ68_23210 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) GPJ68_23215 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) GPJ68_23220 ENOG4107W52 maltose operon periplasmic protein GPJ68_23230 ENOG4108IJ9 (ABC) transporter GPJ68_23235 ENOG4107FKK extracellular solute-binding protein family 1 GPJ68_23240 ENOG4105D56 permease protein GPJ68_23245 ENOG4105EG2 ABC transporter, permease GPJ68_23255 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GPJ68_23260 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPJ68_23265 ENOG4105E3R (LipO)protein GPJ68_23270 ENOG4108Q9C Periplasmic Protein GPJ68_23275 ENOG4108MDC (LipO)protein GPJ68_23290 ENOG4105CFH Aspartokinase GPJ68_23295 ENOG4105C09 Bile acid GPJ68_23300 ENOG4108ZR5 Conserved Protein GPJ68_23305 ENOG4105FE9 pseudouridine synthase GPJ68_23310 ENOG4105ECQ AraC Family Transcriptional Regulator GPJ68_23325 ENOG4105EAM Na Pi-cotransporter GPJ68_23330 ENOG4105C3R Methionine synthase GPJ68_23335 ENOG41069M3 Transcriptional regulator GPJ68_23340 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) GPJ68_23345 ENOG4108I9X Isocitrate lyase GPJ68_23350 ENOG4107QP3 malate synthase g GPJ68_23355 ENOG4105CVG Homoserine O-transsuccinylase GPJ68_23380 ENOG4105C12 Phosphoribosylglycinamide synthetase GPJ68_23385 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPJ68_23390 ENOG4105BZU Histidine kinase GPJ68_23400 ENOG4108T8B Protein of unknown function (DUF1481) GPJ68_23405 ENOG4105K70 DNA-binding protein GPJ68_23410 ENOG4105R2J Conserved Protein GPJ68_23420 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GPJ68_23430 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) GPJ68_23445 ENOG4105D06 uba thif-type nad fad binding protein GPJ68_23450 ENOG4105WHD thiamine biosynthesis protein ThiS GPJ68_23460 ENOG4105D41 biosynthesis protein thiH GPJ68_23465 ENOG4105VEQ Cold shock protein GPJ68_23475 ENOG4105VCP PTS System GPJ68_23480 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPJ68_23485 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GPJ68_23490 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GPJ68_23495 ENOG4108VZM 50s ribosomal protein L10 GPJ68_23500 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) GPJ68_23505 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GPJ68_23510 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GPJ68_23515 ENOG4105PM1 preprotein translocase subunit SecE GPJ68_23550 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GPJ68_23555 ENOG4105D4A Cell wall formation (By similarity) GPJ68_23600 ENOG4108Y73 Membrane GPJ68_23605 ENOG4105EJ2 Transcriptional regulator GPJ68_23615 ENOG4105C5Q Transcriptional regulator GPJ68_23620 ENOG4108NNZ chitinase GPJ68_23625 ENOG4105CH7 arginosuccinase GPJ68_23630 ENOG4105CAS nag kinase GPJ68_23640 ENOG4105CWC Acetylornithine deacetylase GPJ68_23645 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) GPJ68_23650 ENOG4105DIJ Phosphoethanolamine transferase GPJ68_23655 ENOG4106R3P AraC family transcriptional regulator GPJ68_23660 ENOG4108XCZ PTS System GPJ68_23665 ENOG4108AHH pyruvate formate lyase II activase GPJ68_23675 ENOG4108YRF PTS System GPJ68_23680 ENOG4105DM4 PTS System GPJ68_23685 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GPJ68_23695 ENOG4105DCT glycerol dehydrogenase GPJ68_23700 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) GPJ68_23705 ENOG4105SYT Methylenetetrahydrofolate reductase GPJ68_23710 ENOG4105CN8 Transcriptional regulator GPJ68_23720 ENOG4105CGH 5'-nucleotidase GPJ68_23730 ENOG4105CFH Aspartokinase GPJ68_23735 ENOG4105C28 cystathionine GPJ68_23740 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) GPJ68_23745 ENOG4105CT4 transporter GPJ68_23750 ENOG4108QGT oligogalacturonate-specific porin GPJ68_23760 ENOG4105C25 Primosomal protein n' GPJ68_23765 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_23770 ENOG41063M6 Cell Division Protein GPJ68_23780 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GPJ68_23785 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GPJ68_23800 ENOG4105DFP Integrase GPJ68_23820 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) GPJ68_23825 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GPJ68_23830 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GPJ68_23835 ENOG4105CBT Fructose-1,6-bisphosphatase GPJ68_23840 ENOG4105DP0 ferredoxin-NADP reductase GPJ68_23845 ENOG4108VTS Membrane GPJ68_23850 ENOG4105EBK exported protein GPJ68_23865 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) GPJ68_23870 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein GPJ68_23875 ENOG4105CTQ phosphohexokinase GPJ68_23880 ENOG41076HS cation diffusion facilitator family transporter GPJ68_23885 ENOG4105FMW periplasmic GPJ68_23890 ENOG4105E3W Two component transcriptional regulator (Winged helix family GPJ68_23895 ENOG4105E0F Histidine kinase GPJ68_23900 ENOG4105R9B Major Facilitator GPJ68_23905 ENOG4108KHF Resistance protein GPJ68_23910 ENOG4108K85 Transcriptional regulator GPJ68_23915 ENOG4108RPX mosc domain containing protein GPJ68_23920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GPJ68_23930 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GPJ68_23940 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) GPJ68_23945 ENOG4105EDR glucose galactose transporter GPJ68_23950 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GPJ68_23955 ENOG4105C8I hydrolase, family 38 GPJ68_23960 ENOG4105DM4 PTS System GPJ68_23965 ENOG4108YRF PTS System GPJ68_23975 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) GPJ68_23980 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) GPJ68_23990 ENOG4105DKG l-rhamnose isomerase GPJ68_24000 ENOG4105C0A alcohol dehydrogenase GPJ68_24025 ENOG4108UMN azlc family GPJ68_24035 ENOG41064BA PTS system, fructose-specific, IIA component GPJ68_24040 ENOG4105DM4 PTS System GPJ68_24045 ENOG4105CN9 Peptidase m42 family protein GPJ68_24050 ENOG4106C3V frv operon regulatory protein GPJ68_24070 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein GPJ68_24075 ENOG4108MG3 formate dehydrogenase GPJ68_24080 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) GPJ68_24090 ENOG41068KX affects formate dehydrogenase-N GPJ68_24105 ENOG4108Z3N Transcriptional regulator GPJ68_24110 ENOG4105SUU thioesterase domain GPJ68_24120 ENOG4107S2Z UPF0761 membrane protein GPJ68_24125 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 GPJ68_24130 ENOG4105E98 transcriptional regulator DeoR family GPJ68_24135 ENOG4108MGF sugar kinase GPJ68_24140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GPJ68_24145 ENOG4105D2M Aldolase GPJ68_24150 ENOG4107QKS N-acylglucosamine 2-epimerase GPJ68_24155 ENOG4107WI4 Aldose-1-epimerase GPJ68_24160 ENOG4105CJQ hydrolase, family 31 GPJ68_24165 ENOG4105CT4 transporter GPJ68_24170 ENOG4105CT4 transporter GPJ68_24175 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is GPJ68_24180 ENOG4105CI3 gtp-binding protein typa GPJ68_24185 ENOG4105C5F glutamine synthetase GPJ68_24190 ENOG4105CUX Signal transduction histidine kinase GPJ68_24195 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GPJ68_24200 ENOG4106FIY GPJ68_24205 ENOG4105D4P Coproporphyrinogen iii oxidase GPJ68_24225 ENOG4105C2M dna polymerase I GPJ68_24230 ENOG4106HNH Acyl-transferase GPJ68_24235 ENOG4108Z33 Thiol disulfide Interchange Protein GPJ68_24245 ENOG4105PC1 Conserved Protein GPJ68_24250 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GPJ68_24255 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b GPJ68_24285 ENOG4108RR8 protoporphyrinogen oxidase GPJ68_24290 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) GPJ68_24295 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GPJ68_24305 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GPJ68_24315 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_24320 ENOG4105DKQ ROK family GPJ68_24325 ENOG4107QK7 reductase GPJ68_24330 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GPJ68_24335 ENOG4105MDZ Transcriptional activator rfaH GPJ68_24340 ENOG4105F8V Hydrolase, tatD family GPJ68_24345 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GPJ68_24350 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) GPJ68_24355 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GPJ68_24365 ENOG4105JC1 sterol-binding domain protein GPJ68_24375 ENOG4105CGY Dna recombination protein GPJ68_24380 ENOG4107SXA Phosphorylase GPJ68_24385 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) GPJ68_24390 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GPJ68_24395 ENOG4105DZ2 Transcriptional regulator GPJ68_24400 ENOG4105EMK carboxylate amino acid amine transporter GPJ68_24405 ENOG4105DQF Hydrolase GPJ68_24410 ENOG4108EUD Lysophospholipase GPJ68_24415 ENOG410829K Lysine exporter protein (Lyse ygga) GPJ68_24420 ENOG4105CCF Lysine exporter protein (Lyse ygga) GPJ68_24425 ENOG4105C9U ATP-dependent DNA helicase RecQ GPJ68_24430 ENOG4105HDD phospholipase GPJ68_24435 ENOG4108VUY thioesterase Superfamily protein GPJ68_24440 ENOG4105FR1 rard protein GPJ68_24445 ENOG4107QUT magnesium and cobalt transport protein CorA GPJ68_24450 ENOG4105C4R Atp-dependent dna helicase GPJ68_24455 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant GPJ68_24460 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GPJ68_24465 ENOG4105CT0 Protein of unknown function, DUF484 GPJ68_24475 ENOG4105S7Z (LipO)protein GPJ68_24485 ENOG4107T0K Adenylate cyclase GPJ68_24495 ENOG41076E6 Uroporphyrinogen-III Synthase GPJ68_24500 ENOG4105ECF c-methyltransferase GPJ68_24505 ENOG410601J HemY protein GPJ68_24530 ENOG4105C85 amino acid GPJ68_24535 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family GPJ68_24540 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) GPJ68_24545 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) GPJ68_24550 ENOG4105EGZ biosynthesis protein GPJ68_24555 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GPJ68_24560 ENOG4108WJ1 acetyltransferase GPJ68_24565 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GPJ68_24570 ENOG4105C1B dTDP-glucose 4-6-dehydratase GPJ68_24575 ENOG4108IJ1 Dehydrogenase GPJ68_24580 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GPJ68_24585 ENOG4105SFE lipopolysaccharide biosynthesis protein GPJ68_24590 ENOG4105ESV Glycosyl transferase, family 4 GPJ68_24595 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GPJ68_24615 ENOG4105C9X ppx gppa phosphatase GPJ68_24620 ENOG4105C4R Atp-dependent dna helicase GPJ68_24625 ENOG4105KQ5 peptidylprolyl cis-trans isomerase GPJ68_24635 ENOG4105EMY transcriptional regulator GPJ68_24640 ENOG4105RKW reductase (By GPJ68_24645 ENOG4105C7B Threonine dehydratase GPJ68_24655 ENOG4105CM2 brancheD-chain amino acid aminotransferase GPJ68_24660 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit GPJ68_24675 ENOG4105C0P Mg chelatase subunit ChlI GPJ68_24680 ENOG4108WFC UPF0438 protein yifE GPJ68_24720 ENOG4107EJG GntR family transcriptional regulator GPJ68_24725 ENOG4105C0R drug resistance transporter emrb qaca subfamily GPJ68_24730 ENOG4105ETE Transcriptional regulator (LacI family GPJ68_24735 ENOG4108RVA ribokinase GPJ68_24740 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GPJ68_24745 ENOG4105CNN ABC, transporter GPJ68_24755 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GPJ68_24770 ENOG4105EV2 VWA domain protein interacting with AAA ATPase GPJ68_24780 ENOG4108VVK transcriptional Regulator, AsnC GPJ68_24785 ENOG4105QTB Flavodoxin GPJ68_24795 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GPJ68_24800 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation GPJ68_24805 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) GPJ68_24815 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPJ68_24820 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) GPJ68_24825 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GPJ68_24830 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GPJ68_24835 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GPJ68_24840 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GPJ68_24845 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GPJ68_24850 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GPJ68_24855 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) GPJ68_24860 ENOG4105C8U phosphate abc transporter GPJ68_24865 ENOG4105E2Z phosphate ABC transporter (Permease GPJ68_24870 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GPJ68_24880 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 GPJ68_24885 ENOG4105C7N Xanthine uracil vitamin C permease GPJ68_24890 ENOG4108YYH Nadph-dependent fmn reductase GPJ68_24895 ENOG4105E8Q phosphopantetheinyl transferase GPJ68_24900 ENOG4105G2Y Transcriptional regulator GPJ68_24905 ENOG4105CNH Multidrug resistance protein MdtL GPJ68_24910 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GPJ68_24925 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GPJ68_24930 ENOG4105VG0 50S ribosomal protein l34