locus-tag class description HV045_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV045_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HV045_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV045_00025 ENOG410667J hydrolase HV045_00030 ENOG4107WAP fad NAD(P)-binding domain HV045_00035 ENOG4105D99 atp gtp-binding protein HV045_00040 ENOG4105R2A (LipO)protein HV045_00045 ENOG4108ZNX Heat shock protein HV045_00050 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HV045_00065 ENOG4105FDP GntR family transcriptional regulator HV045_00070 ENOG4105CI1 PTS System HV045_00075 ENOG4105F8D glycoside hydrolase family 4 HV045_00080 ENOG4108AHD Transcriptional regulator HV045_00085 ENOG4107RUZ Sss sodium solute transporter superfamily HV045_00090 ENOG4105CBG Sulfatase HV045_00095 ENOG4105VG5 Membrane HV045_00100 ENOG4105JP4 Inner membrane protein yidG HV045_00105 ENOG4105C4X radical SAM domain protein HV045_00110 ENOG4105BZC d-serine deaminase HV045_00120 ENOG4105W8I Transcriptional regulator HV045_00130 ENOG4105E5M Multidrug resistance protein D HV045_00150 ENOG4105C7K acetolactate synthase HV045_00155 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV045_00160 ENOG4107FB0 transcriptional regulator DeoR family HV045_00170 ENOG4105EDR glucose galactose transporter HV045_00180 ENOG4108KX4 response regulator HV045_00185 ENOG4105BZU Histidine kinase HV045_00190 ENOG4105CXY transporter HV045_00200 ENOG4105F9F transposase HV045_00265 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV045_00275 ENOG4105E6M Sulphatase-modifying factor protein HV045_00290 ENOG4105DFP Integrase HV045_00300 ENOG4105CT4 transporter HV045_00305 ENOG4105CJQ hydrolase, family 31 HV045_00310 ENOG4105ETD TRANSCRIPTIONal HV045_00315 ENOG4105DM4 PTS System HV045_00320 ENOG4108YRF PTS System HV045_00325 ENOG4105DM4 PTS System HV045_00330 ENOG4105D2N Aldolase HV045_00335 ENOG4105D2N Aldolase HV045_00345 ENOG4105JV1 AsmA family HV045_00350 ENOG4105C2W permease HV045_00355 ENOG4105D6U Sodium Glutamate Symporter HV045_00360 ENOG4105CB5 ATP-dependent DNA helicase recG HV045_00365 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV045_00370 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV045_00385 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HV045_00390 ENOG4105EN6 Membrane HV045_00395 ENOG4105DSJ YicC domain protein HV045_00400 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HV045_00415 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HV045_00420 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV045_00425 ENOG4105W5Q DNA repair protein (RadC HV045_00435 ENOG4105W0E 50S ribosomal protein L33 HV045_00440 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HV045_00445 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HV045_00450 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV045_00455 ENOG4105DKP glycosyl transferase, family 9 HV045_00460 ENOG4107RJ7 Glycosyl transferase (Group 1 HV045_00465 ENOG4107543 (lipo)polysaccharide HV045_00470 ENOG4106AH0 Glycosyl Transferase HV045_00475 ENOG4105X1N Glycosyl transferase family 8 HV045_00480 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HV045_00485 ENOG4108FRV O-antigen ligase HV045_00490 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV045_00495 ENOG4105XA0 heptosyltransferase ii HV045_00510 ENOG4108SEH involved in lipopolysaccharide biosynthesis HV045_00515 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV045_00520 ENOG4105CPQ Dehydrogenase HV045_00540 ENOG4105K64 Glycosyl transferase, family 2 HV045_00545 ENOG4105PXI polysaccharide deacetylase HV045_00550 ENOG41063SB peptidase HV045_00560 ENOG4107YZP Rhodanese domain protein HV045_00565 ENOG4105VW4 glutaredoxin 3 HV045_00570 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) HV045_00575 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HV045_00580 ENOG4105D7W serine acetyltransferase HV045_00585 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV045_00590 ENOG4105D2S major facilitator superfamily HV045_00595 ENOG4105DMF Dehydrogenase HV045_00600 ENOG41073TP transcriptional regulator HV045_00605 ENOG4105DAA L-lactate HV045_00610 ENOG4108YYI Protein of unknown function (DUF2810) HV045_00620 ENOG4105E61 Mannitol repressor protein HV045_00630 ENOG4105CTS PTS system mannitol-specific HV045_00635 ENOG4105FP6 Protein of unknown function (DUF3302) HV045_00640 ENOG4105EFX secretion protein, HlyD family HV045_00645 ENOG4108U78 Glutathione S-transferase HV045_00655 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV045_00660 ENOG4105C0A alcohol dehydrogenase HV045_00665 ENOG4105C26 Dehydrogenase HV045_00670 ENOG4105KK7 inner membrane protein YiaW HV045_00675 ENOG4105EFX secretion protein, HlyD family HV045_00680 ENOG4108Q2M Transcriptional regulator HV045_00685 ENOG4105GNX MltA-interacting MipA family protein HV045_00695 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV045_00700 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HV045_00705 ENOG4105H6Q decarboxylase HV045_00710 ENOG4105CMG Carbohydrate kinase HV045_00715 ENOG4105DJB Major Facilitator Superfamily HV045_00725 ENOG4108R66 Conserved Protein HV045_00730 ENOG4105DG4 malate L-lactate dehydrogenase HV045_00735 ENOG4105J4Q Transcriptional regulator HV045_00740 ENOG4108XIB electron transport protein ysaA HV045_00745 ENOG4105JKW Valine--pyruvate aminotransferase HV045_00750 ENOG4107T9C Alpha amylase catalytic region HV045_00755 ENOG4108UR8 BAX protein HV045_00760 ENOG4105T16 Transcriptional regulator (AraC family) HV045_00765 ENOG4108HWW ABC transporter HV045_00775 ENOG4105DFW ABC transporter HV045_00785 ENOG4105CMG Carbohydrate kinase HV045_00790 ENOG410688U Inner membrane protein yiaB HV045_00795 ENOG4108Z12 YiaAB two helix domain-containing protein HV045_00800 ENOG4105MEV Acyl-transferase HV045_00815 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HV045_00830 ENOG4105MVF Transcriptional regulator HV045_00835 ENOG4106JH6 (LipO)protein HV045_00840 ENOG4105C5I Dehydrogenase HV045_00845 ENOG4105JHE Major Facilitator Superfamily HV045_00850 ENOG4105D7K pfkb domain protein HV045_00860 ENOG4108M60 Transcriptional regulator HV045_00865 ENOG4108ZG0 Ompa motb domain protein HV045_00870 ENOG4107QY8 reductase HV045_00880 ENOG4108R3E Dna-3-methyladenine glycosylase i HV045_00885 ENOG4105EAX Putative lipase HV045_00890 ENOG4105FCD Major Facilitator HV045_00895 ENOG4105DIJ Phosphoethanolamine transferase HV045_00915 ENOG4105DEF Extracellular solute-binding protein, family 5 HV045_00920 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV045_00925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV045_00930 ENOG4105C3U ABC transporter HV045_00935 ENOG4108JQ7 (ABC) transporter HV045_00940 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV045_00945 ENOG4105C44 Serine transporter HV045_00950 ENOG4105C28 cystathionine HV045_00960 ENOG4105BZU Histidine kinase HV045_00965 ENOG4105CK2 sodium dicarboxylate symporter HV045_00970 ENOG4105CS0 peptidase HV045_00975 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HV045_00980 ENOG4105CMB EAL domain-containing protein HV045_00985 ENOG41066T0 asmA family HV045_00990 ENOG4105CSH Transporter HV045_00995 ENOG4107H3J ribonuclease HV045_01000 ENOG4105CBN LysR family transcriptional regulator HV045_01005 ENOG4105CHR reductase HV045_01010 ENOG4106S2D Transcriptional regulator HV045_01020 ENOG41068WN HV045_01035 ENOG4105CA0 peroxidase HV045_01040 ENOG4105DC8 reductase HV045_01045 ENOG4105D6S protein involved in catabolism of external DNA HV045_01050 ENOG4105DGW oligopeptidase A HV045_01060 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV045_01065 ENOG4105F2I Transposase HV045_01070 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HV045_01075 ENOG4107EDW L-fucose operon activator HV045_01085 ENOG4105CTS PTS system mannitol-specific HV045_01090 ENOG4105CHR reductase HV045_01100 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV045_01105 ENOG4105DUX Transporter HV045_01115 ENOG4108V6B universal stress protein B HV045_01120 ENOG4105CJ3 phosphate transporter HV045_01125 ENOG4105CBX hi0933 family HV045_01205 ENOG4105CJW magnesium transporter HV045_01210 ENOG4105D0S secretion protein (HlyD HV045_01215 ENOG4105CJ1 ABC, transporter HV045_01220 ENOG4105CMI transporter HV045_01225 ENOG4105MRR Transcriptional regulator (By similarity) HV045_01235 ENOG4105PY6 Phenolic acid decarboxylase HV045_01240 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HV045_01245 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV045_01250 ENOG4105C2D reductase HV045_01285 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HV045_01335 ENOG4105DSF transport protein HV045_01340 ENOG4105F9N Major Facilitator Superfamily HV045_01345 ENOG4108W1V Lipoprotein HV045_01350 ENOG4105EX9 Membrane HV045_01365 ENOG4107FS9 Membrane HV045_01375 ENOG4105MG3 Membrane HV045_01380 ENOG4106H78 methyltransferase HV045_01385 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV045_01390 ENOG4105CAK Cell division ATP-binding protein ftsE HV045_01395 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV045_01410 ENOG4105U59 -acetyltransferase HV045_01415 ENOG4105CP9 extracellular ligand-binding receptor HV045_01420 ENOG4105C32 Amino acid ABC transporter (Permease) HV045_01425 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV045_01430 ENOG4105C0Z ABC transporter HV045_01435 ENOG4108IV0 ABC, transporter HV045_01445 ENOG4105BZ7 extracellular solute-binding protein family 1 HV045_01450 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV045_01465 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV045_01470 ENOG4105WC8 Conserved Protein HV045_01475 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV045_01485 ENOG4105WCN acetyltransferase HV045_01490 ENOG4105D9R oxidoreductase HV045_01495 ENOG4105C2I pirin domain protein HV045_01500 ENOG4105DIQ Transcriptional regulator HV045_01505 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV045_01510 ENOG4105C6Z Gluconate HV045_01520 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HV045_01525 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV045_01530 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV045_01535 ENOG4108IUM Glycogen debranching enzyme HV045_01545 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HV045_01550 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV045_01555 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV045_01560 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HV045_01565 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HV045_01570 ENOG4105E98 transcriptional regulator DeoR family HV045_01575 ENOG41061ZR Transcriptional regulator HV045_01580 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV045_01585 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV045_01590 ENOG4105C6Z Gluconate HV045_01595 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HV045_01600 ENOG4105MJ2 Competence protein HV045_01610 ENOG4105DNE Transposase HV045_01620 ENOG4105CE1 Ferrous iron transport protein b HV045_01625 ENOG4105XFK Ferrous iron transport protein A HV045_01630 ENOG4105BZM domain protein HV045_01635 ENOG4108RRZ Transcription elongation factor GreB HV045_01645 ENOG4105E0F Histidine kinase HV045_01650 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HV045_01655 ENOG4108MAJ Membrane HV045_01665 ENOG4105VEJ Heat shock protein HV045_01670 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV045_01675 ENOG4105DQY intracellular growth attenuator HV045_01680 ENOG4107RK2 ADP-ribose diphosphatase NudE HV045_01685 ENOG4108JQC penicillin-binding protein 1A HV045_01690 ENOG4108U1Q Pilus assembly protein HV045_01705 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HV045_01710 ENOG4105E4G Type IV pilus HV045_01715 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HV045_01720 ENOG4105D49 3-dehydroquinate synthase HV045_01725 ENOG4105EGB membrane protein DamX HV045_01730 ENOG4105DFE Dna adenine methylase HV045_01735 ENOG4105DJV ribulose-phosphate 3-epimerase HV045_01740 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HV045_01745 ENOG4105C31 Tryptophanyl-tRNA synthetase HV045_01750 ENOG4105VYH HV045_01760 ENOG4107V9H nitrite transporter HV045_01765 ENOG4105WZK nitrite reductase NADPH small subunit HV045_01770 ENOG4107QZF nitrite reductase NADPH large subunit HV045_01780 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV045_01790 ENOG4105MZU cell filamentation protein HV045_01795 ENOG4105DDQ anthranilate synthase HV045_01800 ENOG4105C8Y Acetylornithine aminotransferase HV045_01810 ENOG4107RYR Transcriptional regulator, Crp Fnr family HV045_01815 ENOG4108UKZ OsmC family HV045_01820 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV045_01830 ENOG4105DNZ Alpha Beta Hydrolase HV045_01835 ENOG4105C5H ABC transporter HV045_01840 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HV045_01845 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV045_01850 ENOG4105VKU nucleicacid-binding protein HV045_01855 ENOG4108YZY peptidylprolyl cis-trans isomerase HV045_01860 ENOG4105VRX Protein slyX homolog HV045_01865 ENOG4108V1T peptidylprolyl cis-trans isomerase HV045_01870 ENOG4105WWK YheO domain protein HV045_01875 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HV045_01880 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV045_01885 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HV045_01900 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HV045_01910 ENOG4105W53 bacterioferritin-associated ferredoxin HV045_01915 ENOG4108UQY Iron-storage protein HV045_01930 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HV045_01935 ENOG4105R04 type II secretion system protein K HV045_01950 ENOG41069X0 general secretion pathway protein h HV045_01955 ENOG4108VAU general secretion pathway protein G HV045_01960 ENOG4105D7Q type ii secretion system HV045_01965 ENOG4107QHF type ii secretion system protein e HV045_01970 ENOG4105GVR general secretion pathway protein D HV045_01995 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HV045_02000 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HV045_02015 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HV045_02020 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HV045_02035 ENOG41083MP 50s ribosomal protein l29 HV045_02040 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HV045_02060 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HV045_02070 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HV045_02080 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HV045_02085 ENOG4105VPB 50S ribosomal protein L30 HV045_02090 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HV045_02095 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV045_02100 ENOG41067V7 50S ribosomal protein L36 HV045_02110 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HV045_02130 ENOG4105VTS DnaJ-like, subfamily C HV045_02135 ENOG4105W1Y Transcriptional regulator HV045_02140 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV045_02145 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HV045_02150 ENOG4105C1A potassium transporter peripheral membrane HV045_02165 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HV045_02170 ENOG4105C79 DNA protecting protein DprA HV045_02180 ENOG4108WI1 Dna topoisomerase HV045_02185 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV045_02190 ENOG4105E2X shikimate dehydrogenase HV045_02195 ENOG4105SG3 Protein of unknown function (DUF1488) HV045_02200 ENOG4108Z0R Transferase HV045_02240 ENOG4105CDA abc transporter atp-binding protein HV045_02245 ENOG4105DRP amino acid AbC transporter HV045_02250 ENOG4105EZ7 amino acid ABC transporter HV045_02260 ENOG4105XCM membrane LIPOPROTEIN HV045_02265 ENOG4105BZS acriflavin resistance protein HV045_02270 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV045_02280 ENOG4108XG4 DNA-binding transcriptional regulator HV045_02285 ENOG41061ME transport protein HV045_02290 ENOG4105CEC DNA methylase N-4 N-6 HV045_02335 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV045_02345 ENOG4108IA2 Sodium pantothenate symporter HV045_02350 ENOG4105RG0 Membrane HV045_02355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV045_02360 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV045_02375 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV045_02380 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV045_02390 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV045_02395 ENOG4105VQ7 Rod shape-determining protein MreD HV045_02405 ENOG4105C03 ribonuclease HV045_02410 ENOG4105QD6 exported protein HV045_02415 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV045_02420 ENOG4105CR8 Transcriptional regulator HV045_02425 ENOG4105ZQC membrane protein AaeX HV045_02430 ENOG4105Y49 secretion protein, HlyD family HV045_02435 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) HV045_02440 ENOG4105UNR (Barnase) inhibitor HV045_02450 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV045_02460 ENOG4105C0H protease HV045_02465 ENOG4105C0H protease HV045_02470 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV045_02475 ENOG4105D6Z AFG1 family ATPase HV045_02480 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HV045_02490 ENOG4107MKT Stringent starvation protein a HV045_02495 ENOG4105KB2 stringent starvation protein b HV045_02500 ENOG4105CEE C4-dicarboxylate transporter HV045_02510 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV045_02515 ENOG4105JHE Major Facilitator Superfamily HV045_02525 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HV045_02530 ENOG4108R66 Conserved Protein HV045_02535 ENOG4105DZC cytosine deaminase HV045_02540 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV045_02545 ENOG4105BZ8 glutamate synthase HV045_02550 ENOG4105CBC glutamate synthase HV045_02555 ENOG4105N5T Radical SAM Protein HV045_02560 ENOG4105BZU Histidine kinase HV045_02565 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV045_02570 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HV045_02575 ENOG41080Z8 PHOSPHOCARRIER protein HV045_02580 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HV045_02585 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV045_02590 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV045_02595 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV045_02600 ENOG4108IUZ ABC transporter HV045_02605 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV045_02610 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV045_02615 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HV045_02620 ENOG4105C2X Arabinose 5-phosphate isomerase HV045_02625 ENOG4105FEU K -dependent Na -Ca exchanger HV045_02630 ENOG4105DHJ ABC, transporter HV045_02635 ENOG4105CY3 ABC transporter, permease HV045_02640 ENOG4107PE3 Mammalian cell entry related domain protein HV045_02645 ENOG4105E3I toluene tolerance HV045_02650 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV045_02655 ENOG4105VFK BolA family HV045_02665 ENOG4105HVQ Regulatory factor of maltose metabolism HV045_02670 ENOG4105EAH synthase HV045_02675 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HV045_02680 ENOG4105K46 50S ribosomal protein l27 HV045_02685 ENOG4105QYV Membrane HV045_02690 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HV045_02695 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV045_02700 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV045_02705 ENOG4105HBR Rna-binding protein HV045_02715 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV045_02720 ENOG4105EEI dihydropteroate synthase HV045_02725 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HV045_02730 ENOG4105CEE C4-dicarboxylate transporter HV045_02735 ENOG4105DYB Isoaspartyl dipeptidase HV045_02740 ENOG4107YNJ LysR family Transcriptional regulator HV045_02745 ENOG4105NTZ Preprotein translocase subunit SecG HV045_02755 ENOG4105CDH Citrulline--aspartate ligase HV045_02765 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HV045_02770 ENOG4105CHV Transcription elongation factor NusA HV045_02775 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HV045_02780 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HV045_02810 ENOG4105C1J atp-dependent rna helicase HV045_02815 ENOG4105CIC tryptophan-specific transport protein HV045_02820 ENOG4105DEN Luciferase family HV045_02840 ENOG4108YYD acetyltransferase HV045_02845 ENOG41082IR Excinuclease ABC C subunit domain protein HV045_02850 ENOG4108ZPB UPF0306 protein HV045_02855 ENOG4105K4T epimerase HV045_02860 ENOG4105W4M Transport-associated protein HV045_02865 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HV045_02875 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HV045_02880 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV045_02885 ENOG4107R3N Filamentation induced by cAMP protein fic HV045_02895 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HV045_02900 ENOG4105DT3 PTS system, galactitol-specific IIc component HV045_02905 ENOG41090UW PTS System HV045_02910 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HV045_02925 ENOG4105CTX dehydratase HV045_02930 ENOG4105DJB Major Facilitator Superfamily HV045_02935 ENOG4105CNV Aldolase HV045_02940 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV045_02945 ENOG4105BZW Glycerate kinase HV045_02965 ENOG4105MN3 Resolvase HV045_02970 ENOG4105I03 Flagellin HV045_02985 ENOG4105F9F transposase HV045_02995 ENOG4105EKQ RNA-directed DNA polymerase HV045_03005 ENOG410811B TRANSCRIPTIONal HV045_03010 ENOG4105C7B Threonine dehydratase HV045_03015 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HV045_03025 ENOG4105C6N Formate acetyltransferase HV045_03030 ENOG4105KME endoribonuclease L-psp HV045_03035 ENOG4105EJQ L-serine dehydratase HV045_03040 ENOG4105C44 Serine transporter HV045_03050 ENOG4106D80 Uncharacterized protein YhaL HV045_03055 ENOG4108CNN domain protein HV045_03060 ENOG4105CWB LysR family transcriptional Regulator HV045_03065 ENOG4105KAF membrAne HV045_03070 ENOG4105CHF Glutathione S-transferase HV045_03075 ENOG4108VBZ doxx family HV045_03080 ENOG4105YJD HV045_03085 ENOG41090KG Inner membrane protein YqjE HV045_03090 ENOG4105NE1 Conserved Protein HV045_03095 ENOG4105WAY exported protein HV045_03105 ENOG4106W5V Membrane HV045_03110 ENOG4107YCY Transcriptional regulator HV045_03115 ENOG4105DPW Major facilitator superfamily MFS_1 HV045_03125 ENOG4105CTX dehydratase HV045_03130 ENOG4105P66 Membrane HV045_03140 ENOG4105DU1 integral membrane protein, terc HV045_03145 ENOG4105EE0 oxidoreductase HV045_03150 ENOG4108VKG metal-dependent hydrolase HV045_03155 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV045_03160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV045_03185 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HV045_03190 ENOG4105DRS transport system, permease HV045_03200 ENOG4105HY2 Glycosidase related protein HV045_03215 ENOG4105CNT hydrolase family 2 HV045_03220 ENOG4105CQ4 Transcriptional regulator HV045_03225 ENOG4108Y51 tRNA-binding protein HV045_03230 ENOG4105C8Y Acetylornithine aminotransferase HV045_03235 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV045_03240 ENOG4105NTW Transcriptional regulator HV045_03245 ENOG4105Q26 Siderophore-interacting protein HV045_03255 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV045_03300 ENOG4105YCI dehydratase medium subunit HV045_03305 ENOG4108ZFT Dehydratase small subunit HV045_03310 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV045_03315 ENOG4105V2F Uncharacterized protein yoac HV045_03320 ENOG4108KU3 Integrase HV045_03360 ENOG4105KSC Transcriptional regulator, TraR DksA family HV045_03385 ENOG4105DFE Dna adenine methylase HV045_03405 ENOG4105ED4 portal protein HV045_03505 ENOG4105UZW Tail fiber assembly protein HV045_03560 ENOG4105MZU cell filamentation protein HV045_03580 ENOG4108P8R HV045_03585 ENOG4105JXR Protein of unknown function (DUF3296) HV045_03600 ENOG4105F2I Transposase HV045_03605 ENOG4108MXD gtp-binding protein HV045_03610 ENOG4106H6R UPF0380 protein HV045_03615 ENOG4108KZE transcriptional regulator HV045_03620 ENOG4105F4K antigen 43 HV045_03625 ENOG4105MFG Antirestriction protein HV045_03630 ENOG4108XS9 dna repair protein HV045_03635 ENOG4105ZS6 Protein of unknown function (DUF987) HV045_03640 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV045_03675 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV045_03680 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV045_03690 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV045_03695 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HV045_03700 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV045_03705 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) HV045_03710 ENOG4105CQM Urea amidohydrolase subunit alpha HV045_03715 ENOG4105KI2 Urea amidohydrolase subunit beta HV045_03720 ENOG4108YZ9 Urea amidohydrolase subunit gamma HV045_03725 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HV045_03730 ENOG4107QPK )-transporter HV045_03735 ENOG4107GFK fumarate HV045_03740 ENOG4106DSS Tartrate dehydratase subunit alpha HV045_03745 ENOG4105EJC lysr family transcriptional regulator HV045_03750 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HV045_03755 ENOG4107ZVW dihydroneopterin aldolase HV045_03760 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HV045_03765 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HV045_03770 ENOG4106MWK domain protein HV045_03775 ENOG4105I7R Adenylate cyclase HV045_03780 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HV045_03785 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HV045_03795 ENOG4105W0Z cytoplasmic protein HV045_03805 ENOG4108PSN Required for disulfide bond formation in some proteins. Part of a redox system composed of DsbI and DsbL that mediates formation of an essential disulfide bond in AssT (By similarity) HV045_03840 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV045_03845 ENOG4106032 Glutathionylspermidine synthase HV045_03850 ENOG4105F1G UPF0441 protein HV045_03855 ENOG4105DFG type I secretion outer membrane protein HV045_03860 ENOG41087AY ADP-Ribose pyrophosphatase HV045_03865 ENOG4108SX3 cytoplasmic protein HV045_03870 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV045_03875 ENOG4105IPS esterase HV045_03880 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV045_03885 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV045_03890 ENOG4105NF4 modulator of drug activity HV045_03895 ENOG4105DHQ Histidine kinase HV045_03900 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV045_03905 ENOG4105H4F exported protein HV045_03910 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV045_03915 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV045_03920 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV045_03925 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV045_03930 ENOG4105CCT upf0313 protein HV045_03940 ENOG4105CV8 reductase HV045_03945 ENOG4108I6A alcohol dehydrogenase HV045_03950 ENOG4105CF7 AraC family transcriptional regulator HV045_03955 ENOG4108K81 inner membrane protein YghB HV045_03960 ENOG4105C28 cystathionine HV045_03965 ENOG4105CWK Biopolymer transport protein, ExbB HV045_03970 ENOG4108ZZF transport protein (ExbD) HV045_03990 ENOG4105CPC Aldo Keto reductase HV045_04000 ENOG4105C8Q Methyl-accepting chemotaxis HV045_04005 ENOG410900S Protein of unknown function (DUF2623) HV045_04010 ENOG4105E3S small subunit HV045_04015 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV045_04020 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HV045_04025 ENOG4105DPX Hydrogenase, large subunit HV045_04030 ENOG4108USZ hydrogenase HV045_04035 ENOG4108WGS hydrogenase 2-specific chaperone HV045_04040 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV045_04045 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HV045_04050 ENOG4105CYM Glutathione S-transferase HV045_04055 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HV045_04060 ENOG4106032 Glutathionylspermidine synthase HV045_04085 ENOG4108ZG0 Ompa motb domain protein HV045_04095 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV045_04125 ENOG4105F2I Transposase HV045_04185 ENOG4105F2I Transposase HV045_04205 ENOG4105C8Q Methyl-accepting chemotaxis HV045_04260 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase HV045_04265 ENOG41080HT Transcriptional regulator, arsr family HV045_04285 ENOG4105VYW UPF0251 protein HV045_04290 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_04315 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV045_04330 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HV045_04335 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_04350 ENOG4105F2I Transposase HV045_04355 ENOG4108UEC Ferritin-like protein HV045_04420 ENOG41088T4 Helicase IV HV045_04440 ENOG4108UQV Membrane HV045_04445 ENOG4105CXN decarboxylase HV045_04450 ENOG4105EAA nucleoside HV045_04455 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HV045_04460 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HV045_04465 ENOG4105CEN a g-specific adenine glycosylase HV045_04475 ENOG41090ED Protein with unknown function (DUF469) HV045_04480 ENOG4105K33 Periplasmic Protein HV045_04485 ENOG4105HDK L-asparaginase HV045_04495 ENOG4105CSA Coproporphyrinogen iii oxidase HV045_04505 ENOG4105VZ9 UPF0235 protein HV045_04510 ENOG4108VIA integral membrane protein HV045_04515 ENOG4105DFA alanine racemase domain protein HV045_04535 ENOG4105CZX twitching motility protein HV045_04540 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HV045_04545 ENOG4108UJU UPF0301 protein HV045_04550 ENOG4105D7Z glutathione synthase HV045_04555 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV045_04560 ENOG4105RWS endonuclease I HV045_04565 ENOG4105GPY SprT protein HV045_04570 ENOG4107QNK )-transporter HV045_04575 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HV045_04590 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV045_04600 ENOG4108K0D peptidase, M48 HV045_04605 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV045_04615 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV045_04620 ENOG4105CTS PTS system mannitol-specific HV045_04625 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV045_04630 ENOG4108Q8A Fructose-1,6-bisphosphatase HV045_04635 ENOG4108R4K DNA-binding, transcriptional regulator HV045_04640 ENOG4107Z1W Fructose transport system kinase HV045_04645 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV045_04650 ENOG4105BZA Phosphoglycerate kinase HV045_04655 ENOG4105D2N Aldolase HV045_04660 ENOG4105C5B carbamate kinase HV045_04670 ENOG4107R1Q Membrane protein FdrA HV045_04675 ENOG4107REC cytoplasmic protein HV045_04680 ENOG4105G5A Protein of unknown function (DUF2877) HV045_04685 ENOG4107653 Transcriptional regulator HV045_04690 ENOG4105D64 Mechanosensitive ion channel HV045_04700 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HV045_04705 ENOG4105MPN Membrane HV045_04710 ENOG4105DEQ transcriptional regulator HV045_04715 ENOG4105CYC Transferase HV045_04720 ENOG4108M7F enoyl-CoA hydratase isomerase HV045_04725 ENOG4105DJT lAO AO transport system ATPase HV045_04730 ENOG4105D5P Methylmalonyl-coA mutase HV045_04735 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HV045_04745 ENOG4108JQ1 Dehydrogenase HV045_04750 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV045_04760 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HV045_04770 ENOG4107RAQ aminopeptidase HV045_04775 ENOG4105D0A hydroxylase HV045_04780 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV045_04795 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HV045_04800 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV045_04805 ENOG4105CS2 ec 3.2.1.21 HV045_04810 ENOG4108Q3X Transcriptional regulator HV045_04820 ENOG4108UT2 hemolysin iii HV045_04830 ENOG4105Y75 tpr repeat protein HV045_04835 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV045_04840 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV045_04845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV045_04850 ENOG4105T95 Thiol disulfide interChange protein HV045_04855 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV045_04865 ENOG4105CRK lysyL-tRNA synthetase HV045_04875 ENOG4108K5P (LipO)protein HV045_04885 ENOG4105DFP Integrase HV045_04920 ENOG4105ETT transcriptional Regulator, LysR family HV045_04930 ENOG4105E5Q amino acid AbC transporter HV045_04935 ENOG4105E5Q amino acid AbC transporter HV045_04940 ENOG4108JEH abc transporter atp-binding protein HV045_05015 ENOG4105X0I Fimbrial HV045_05070 ENOG410679B prophage CP4-57 regulatory protein alpA HV045_05080 ENOG4108P8R HV045_05090 ENOG4106H6R UPF0380 protein HV045_05100 ENOG4106549 Antirestriction protein HV045_05105 ENOG4108XS9 dna repair protein HV045_05110 ENOG4105ZS6 Protein of unknown function (DUF987) HV045_05115 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV045_05130 ENOG4105F2I Transposase HV045_05140 ENOG4106PQC HV045_05155 ENOG4105F2I Transposase HV045_05165 ENOG41090SZ ABC-2 type transporter HV045_05170 ENOG4107U8J Export protein HV045_05175 ENOG4107TAE Glycosyl transferase (Group 1 HV045_05180 ENOG4105F2I Transposase HV045_05190 ENOG4107BJW polysaccharide deacetylase HV045_05195 ENOG4105CND Glycosyl transferase, family 2 HV045_05205 ENOG4105VR1 Pfam:DUF1271 HV045_05210 ENOG410830R acetyltransferase HV045_05215 ENOG4108NUU Transcriptional regulator HV045_05220 ENOG4107SNB ankyrin repeat protein YahD HV045_05225 ENOG4105N16 Protein of unknown function (DUF2877) HV045_05230 ENOG4107R1Q Membrane protein FdrA HV045_05235 ENOG4107REC cytoplasmic protein HV045_05245 ENOG4105C5B carbamate kinase HV045_05250 ENOG4105DZC cytosine deaminase HV045_05255 ENOG41061MD high-affinity nickel-transporter HV045_05265 ENOG4108MHD transport protein HV045_05275 ENOG4105C5Q Transcriptional regulator HV045_05280 ENOG4105CHU acetyl-coa acetyltransferase HV045_05290 ENOG4105CHR reductase HV045_05305 ENOG4105RQF LysR family Transcriptional regulator HV045_05315 ENOG4105DDV Transcriptional regulator (LacI family HV045_05330 ENOG4107S74 Lysophospholipid transporter LplT HV045_05335 ENOG4105CPC Aldo Keto reductase HV045_05340 ENOG4105SUV lipoprotein YgdR HV045_05345 ENOG4105EE5 Membrane protein terC HV045_05360 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV045_05375 ENOG4105IPU prepilin peptidase dependent protein A HV045_05380 ENOG4105JCS prepilin peptidase dependent protein HV045_05385 ENOG4105SEN Protein of unknown function (DUF2509) HV045_05390 ENOG4105RVB Prepilin peptidase dependent protein c HV045_05395 ENOG4105DSY exodeoxyribonuclease V, gamma HV045_05400 ENOG4107QXK peptidase HV045_05405 ENOG4107QKA exodeoxyribonuclease V beta HV045_05410 ENOG4107QYX exodeoxyribonuclease v alpha HV045_05415 ENOG4108EKC n-acetylglutamate synthase HV045_05420 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV045_05440 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV045_05445 ENOG4105CUZ uba thif-type nad fad binding protein HV045_05450 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV045_05455 ENOG4105C9B Cysteine desulfurase HV045_05460 ENOG4105M5B (LipO)protein HV045_05465 ENOG4105ETT transcriptional Regulator, LysR family HV045_05470 ENOG4105M08 Membrane HV045_05475 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HV045_05480 ENOG4107EDW L-fucose operon activator HV045_05490 ENOG4105CMG Carbohydrate kinase HV045_05495 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HV045_05500 ENOG4105C2J ABC transporter HV045_05505 ENOG4105CNN ABC, transporter HV045_05525 ENOG4107W7X Aldolase HV045_05530 ENOG4105C0A alcohol dehydrogenase HV045_05535 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease HV045_05540 ENOG4105EJQ L-serine dehydratase HV045_05545 ENOG4105C44 Serine transporter HV045_05550 ENOG4105EWT decarboxylase family HV045_05555 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HV045_05560 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) HV045_05565 ENOG4105WP7 tRNA pseudouridine synthase C HV045_05570 ENOG4105DR9 pseudouridine synthase HV045_05575 ENOG4105QDK Flavodoxin HV045_05580 ENOG4105DJB Major Facilitator Superfamily HV045_05585 ENOG4105EQX glucarate dehydratase HV045_05590 ENOG4105EQX glucarate dehydratase HV045_05595 ENOG4105BZW Glycerate kinase HV045_05600 ENOG4105BZU Histidine kinase HV045_05605 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HV045_05610 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV045_05615 ENOG4105DXN mazG family HV045_05630 ENOG4105QEK Transcriptional regulator HV045_05640 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HV045_05645 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV045_05650 ENOG4108CWB sugar kinase ygcE HV045_05655 ENOG4108ITV Inner membrane protein yqcE HV045_05660 ENOG4105CHR reductase HV045_05665 ENOG4107R3A FAD linked oxidase domain protein HV045_05670 ENOG4105C54 Major Facilitator superfamily HV045_05675 ENOG4106IKH Electron transfer flavoprotein HV045_05680 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HV045_05685 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HV045_05690 ENOG4105WQV ferredoxin-like protein HV045_05695 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV045_05700 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV045_05705 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HV045_05720 ENOG4105DTT CRISPR-associated helicase, cas3 HV045_05725 ENOG4105CYR Crispr-associated protein, cse1 family HV045_05735 ENOG41060M0 Crispr-associated protein, cse4 family HV045_05740 ENOG4108VWQ crispr-associated protein HV045_05750 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HV045_05755 ENOG4105PWE CRISPR-associated protein cas2 HV045_05760 ENOG4108MXK alkaline phosphatase isozyme conversion HV045_05770 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HV045_05780 ENOG4105N0Z inner membrane protein ygbE HV045_05785 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV045_05800 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HV045_05805 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HV045_05810 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HV045_05815 ENOG4108K5P (LipO)protein HV045_05855 ENOG4105BZU Histidine kinase HV045_05860 ENOG4105CC5 ABC transporter HV045_05865 ENOG4105CC5 ABC transporter HV045_05870 ENOG4105DIK (ABC) transporter HV045_05880 ENOG4105VXR cytoplasmic protein HV045_05890 ENOG4105C45 hydrogenase expression formation protein (HypE) HV045_05895 ENOG4105CQS hydrogenase expression formation protein HypD HV045_05900 ENOG41083WG hydrogenase assembly chaperone HV045_05905 ENOG4107RSS Hydrogenase accessory protein HypB HV045_05910 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV045_05915 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV045_05920 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV045_05925 ENOG4107R30 NADH dehydrogenase HV045_05930 ENOG4107TDF Formate hydrogenlyase subunit 4 HV045_05935 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV045_05940 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV045_05945 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV045_05950 ENOG4105I6X formate hydrogenlyase maturation HV045_05955 ENOG4108MG9 hydrogenase 3 maturation protease HV045_05970 ENOG4105CS2 ec 3.2.1.21 HV045_05975 ENOG4105C5Y PTS System HV045_05980 ENOG4105DDV Transcriptional regulator (LacI family HV045_05985 ENOG4108RC0 Electron transport protein HV045_05990 ENOG4105C8H hydrogenase maturation protein Hypf HV045_05995 ENOG4107QZF nitrite reductase NADPH large subunit HV045_06000 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HV045_06005 ENOG4108JUA Transcriptional regulator HV045_06010 ENOG4105C2X Arabinose 5-phosphate isomerase HV045_06015 ENOG410804X Transcriptional regulator HV045_06020 ENOG4105J92 DNA-binding transcriptional activator GutM HV045_06025 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HV045_06030 ENOG4105VI0 Pts system, glucitol sorbitol-specific HV045_06035 ENOG4105DZY Pts system, glucitol sorbitol-specific HV045_06040 ENOG410787A Pts system, glucitol sorbitol-specific HV045_06045 ENOG4105CVE Lytic murein transglycosylase HV045_06050 ENOG4107TH8 cina domain protein HV045_06055 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HV045_06065 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HV045_06070 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV045_06095 ENOG4107VXZ Hydrolase HV045_06100 ENOG4105W39 Membrane HV045_06110 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HV045_06115 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV045_06120 ENOG4105CW7 secretion protein, HlyD family HV045_06125 ENOG4105NTK Transcriptional repressor Mpra HV045_06130 ENOG4105ZED uncharacterized protein ygaH HV045_06135 ENOG4108UMN azlc family HV045_06145 ENOG4105GIJ Glycine betaine HV045_06150 ENOG4108HQS Glycine betaine HV045_06155 ENOG4108IJ7 Glycine betaine HV045_06160 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV045_06165 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV045_06170 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HV045_06175 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV045_06180 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV045_06190 ENOG4108WMJ Protein of unknown function (DUF2002) HV045_06195 ENOG4108RNS Exports L-alanine (By similarity) HV045_06200 ENOG4108X73 DNA- binding protein HV045_06210 ENOG4108V62 Rhodanese domain protein HV045_06215 ENOG41080HT Transcriptional regulator, arsr family HV045_06220 ENOG4105VPI YqaE family transport protein HV045_06225 ENOG4109066 lysm domain bon superfamily protein HV045_06230 ENOG4108PVQ transcriptional regulator HV045_06235 ENOG4105C85 amino acid HV045_06240 ENOG4108JPW Aminotransferase HV045_06245 ENOG4105C26 Dehydrogenase HV045_06250 ENOG4105D5U fad dependent oxidoreductase HV045_06265 ENOG4105F2I Transposase HV045_06320 ENOG41088YS Glycosyl transferase (Group 1 HV045_06325 ENOG4107RA4 Glycosyl transferase (Group 1 HV045_06340 ENOG4105CMR udp-glucose 4-epimerase HV045_06350 ENOG4107B2H carbonic anhydrase HV045_06355 ENOG4105C87 Aminotransferase class I and II HV045_06370 ENOG4105DFP Integrase HV045_06380 ENOG4105F9F transposase HV045_06390 ENOG4105F9F transposase HV045_06470 ENOG4105DZR Type I site-specific deoxyribonuclease HV045_06480 ENOG4105CVR type I restriction-modification system HV045_06490 ENOG4105DFP Integrase HV045_06525 ENOG4108Z1B Cyclase dehydrase HV045_06530 ENOG4105VDB UPF0125 protein HV045_06535 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV045_06540 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV045_06555 ENOG4108JU6 CBS domain protein HV045_06560 ENOG4106KVJ cytochrome C assembly protein HV045_06565 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV045_06570 ENOG4105K5M 30s ribosomal protein S16 HV045_06575 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HV045_06585 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HV045_06590 ENOG41090EK ompa motb domain protein HV045_06595 ENOG4108KHX Diguanylate cyclase HV045_06600 ENOG4108WS1 HV045_06605 ENOG4105QP9 Protein of unknown function (DUF2799) HV045_06610 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV045_06615 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV045_06620 ENOG4105CQC Prephenate dehydratase HV045_06630 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV045_06635 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV045_06640 ENOG4105C34 Pseudouridine synthase HV045_06645 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV045_06650 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV045_06680 ENOG4105CSH Transporter HV045_06685 ENOG4105T42 (LipO)protein HV045_06690 ENOG4105JIM Phosphatidylserine synthase HV045_06695 ENOG4105CD5 CoA-binding domain protein HV045_06700 ENOG4106IUH DTW domain containing protein HV045_06705 ENOG4105K63 Thioredoxin HV045_06710 ENOG4105EIB trna rrna methyltransferase HV045_06725 ENOG4105C1J atp-dependent rna helicase HV045_06735 ENOG4108IYU L-aspartate oxidase HV045_06745 ENOG4105EMN RNA polymerase sigma factor HV045_06755 ENOG4105VQK sigma E regulatory protein, MucB RseB HV045_06760 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV045_06770 ENOG4105C3F Signal peptidase i HV045_06780 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HV045_06790 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV045_06795 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HV045_06800 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV045_06880 ENOG4105RDA repressor HV045_06885 ENOG41078CG DNA-binding transcriptional regulator HV045_06890 ENOG4108S1U HV045_06920 ENOG4105HRS Antitermination protein HV045_06935 ENOG4105NVB glycoside hydrolase, family 19 HV045_07075 ENOG4108US3 tail fiber assembly HV045_07085 ENOG4108C33 Resolvase HV045_07090 ENOG4106G6Q Transcriptional regulator HV045_07095 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HV045_07105 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV045_07110 ENOG4108Z6B deaminase HV045_07115 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV045_07125 ENOG4107WP9 Histidine kinase HV045_07130 ENOG4108SKK alpha helix protein HV045_07135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV045_07140 ENOG4108YZA Nitrogen regulatory protein pii HV045_07145 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV045_07150 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HV045_07155 ENOG4108NZE NAGC-like transcriptional regulator HV045_07160 ENOG4107HQ7 repeat protein HV045_07165 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HV045_07170 ENOG4108F37 ATP-binding component of a transport system HV045_07175 ENOG4105CNN ABC, transporter HV045_07180 ENOG4105CPQ Dehydrogenase HV045_07185 ENOG4108ZKT aldose 1-epimerase HV045_07210 ENOG4105FUY alpha subunit HV045_07215 ENOG4108W5M transcriptional regulator HV045_07220 ENOG4105I74 Fimbrial protein HV045_07225 ENOG4105CW0 outer membrane usher protein HV045_07230 ENOG4108VCD Chaperone HV045_07235 ENOG4105Q10 Fimbrial-like protein HV045_07240 ENOG4105D8G Major Facilitator superfamily HV045_07245 ENOG4108MN2 Stationary phase inducible protein CsiE HV045_07250 ENOG4105C2X Arabinose 5-phosphate isomerase HV045_07255 ENOG4105EF1 ribulokinase HV045_07265 ENOG4105CNN ABC, transporter HV045_07270 ENOG4105C2J ABC transporter HV045_07280 ENOG41065CD Exported protein HV045_07285 ENOG4105D7X high-affinity nickel-transporter HV045_07290 ENOG4105ECY inositol monophosphatase HV045_07295 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HV045_07300 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HV045_07310 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV045_07315 ENOG4108Z4V iron-sulfur cluster assembly HV045_07330 ENOG4108ZIT Ferredoxin, 2FE-2S HV045_07335 ENOG4105WVQ Fe-S assembly protein IscX HV045_07340 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV045_07345 ENOG4105YYA enhanced serine sensitivity protein SseB HV045_07350 ENOG4105KHC sulfurtransferase HV045_07355 ENOG4105DN3 alpha-2-macroglobulin domain protein HV045_07360 ENOG4108JQB penicillin-binding protein 1C HV045_07370 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HV045_07375 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HV045_07380 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HV045_07390 ENOG4105N21 Membrane HV045_07395 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV045_07400 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HV045_07405 ENOG4105DUX Transporter HV045_07415 ENOG4105VPD cellular component movement HV045_07420 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HV045_07425 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV045_07435 ENOG41062G3 Protein of unknown function (DUF2633) HV045_07440 ENOG4105BZU Histidine kinase HV045_07445 ENOG4105C9X ppx gppa phosphatase HV045_07450 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HV045_07455 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV045_07465 ENOG4105CS2 ec 3.2.1.21 HV045_07470 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HV045_07475 ENOG4105C2W permease HV045_07480 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV045_07485 ENOG4105K89 arsenate reductase HV045_07490 ENOG4105ERG peptidase m48, ste24p HV045_07495 ENOG4105C02 permease HV045_07500 ENOG41074DU domain protein HV045_07505 ENOG4108P2H Inner membrane protein YjiG HV045_07510 ENOG4105DYB Isoaspartyl dipeptidase HV045_07515 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV045_07520 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV045_07530 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV045_07540 ENOG4105CGZ zinc metallopeptidase HV045_07545 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HV045_07550 ENOG4106KED esterase YpfH HV045_07560 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HV045_07565 ENOG4105KUZ arsenate reductase HV045_07580 ENOG4105BZU Histidine kinase HV045_07585 ENOG4105BZ8 glutamate synthase HV045_07595 ENOG4108PVD exported protein HV045_07600 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV045_07605 ENOG4105C6K Malic enzyme HV045_07610 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HV045_07615 ENOG4106S4J ethanolamine utilization protein EutP HV045_07620 ENOG4105NDK ethanolamine utilization protein HV045_07625 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HV045_07630 ENOG4108IJ2 phosphate acetyltransferase HV045_07635 ENOG4105KNY Microcompartments protein HV045_07640 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV045_07645 ENOG4108EKI Dehydrogenase HV045_07650 ENOG4107YMV ethanolamine utilization protein HV045_07655 ENOG4105C0A alcohol dehydrogenase HV045_07660 ENOG4105ENY Ethanolamine utilization protein eutH HV045_07665 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HV045_07670 ENOG4105CPD ethanolamine ammonia-lyase HV045_07680 ENOG4106D67 ethanolamine utilization protein HV045_07685 ENOG4108X49 Ethanolamine utilization protein EutK HV045_07690 ENOG4108K3Z AraC family transcriptional regulator HV045_07700 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV045_07705 ENOG4108R6G acetyltransferase HV045_07710 ENOG4105QZU Inner membrane protein YfeZ HV045_07715 ENOG4105E7K (LipO)protein HV045_07720 ENOG4105EZR dyp-type peroxidase family protein HV045_07725 ENOG4105CH7 arginosuccinase HV045_07735 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV045_07740 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV045_07745 ENOG4105JXH GntR family transcriptional regulator HV045_07750 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HV045_07755 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV045_07760 ENOG4108I5D sulfate abc transporter HV045_07765 ENOG4105ECW sulfate abc transporter HV045_07770 ENOG4108IJ6 ABC transporter HV045_07775 ENOG4105C6T cysteine synthase HV045_07780 ENOG41089BK Glutamine amido-transferase HV045_07785 ENOG4105CSW GntR family transcriptional regulator HV045_07790 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV045_07800 ENOG4105C5Y PTS System HV045_07805 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV045_07810 ENOG4105KZ7 phosphocarrier protein hpr HV045_07815 ENOG4105C6T cysteine synthase HV045_07830 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HV045_07835 ENOG4105VRT cytoplasmic protein HV045_07840 ENOG4105DHU Bile acid HV045_07845 ENOG4108M0I Transcriptional regulator HV045_07875 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HV045_07880 ENOG4105GXM Putative transcription regulator (DUF1323) HV045_07885 ENOG4105HZG regulatoR HV045_07900 ENOG4105D9N nucleoside HV045_07905 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HV045_07915 ENOG4105CE4 GlcNAc 6-P deacetylase HV045_07920 ENOG4105C83 adenylosuccinate lyase HV045_07925 ENOG4105CI1 PTS System HV045_07930 ENOG4109076 Conserved Protein HV045_07935 ENOG4105CPC Aldo Keto reductase HV045_07940 ENOG4107RA9 decarboxylase HV045_07955 ENOG4105CHC glucokinase (EC 2.7.1.2) HV045_07960 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV045_07965 ENOG410863U PTS System HV045_07970 ENOG4105DC7 peptidase M24 HV045_07975 ENOG4105CN9 Peptidase m42 family protein HV045_07980 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV045_07990 ENOG4108CIP transcriptional regulator HV045_07995 ENOG4105DY9 regulatoR HV045_08000 ENOG4108HRK Histidine kinase HV045_08005 ENOG4105CHM Aminotransferase HV045_08020 ENOG4105D1S lipid A biosynthesis HV045_08025 ENOG4105W9M Membrane HV045_08030 ENOG4105CXY transporter HV045_08035 ENOG4106JDA Phosphoglycerate transport regulatory protein PGTC HV045_08045 ENOG4107TXD phosphoglycerate transport system transcriptional regulatory protein pgta HV045_08050 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV045_08055 ENOG4105C8Q Methyl-accepting chemotaxis HV045_08060 ENOG4105D44 asparaginase HV045_08125 ENOG4105DFP Integrase HV045_08230 ENOG4108S1U HV045_08260 ENOG4105HRS Antitermination protein HV045_08275 ENOG4105NVB glycoside hydrolase, family 19 HV045_08305 ENOG4105CAR Terminase, large subunit HV045_08315 ENOG4105EFC phage portal protein HK97 family HV045_08425 ENOG4108C33 Resolvase HV045_08430 ENOG4105Y50 Virulence Protein HV045_08435 ENOG4105KT5 UmuD protein HV045_08440 ENOG4105S64 Formate nitrite transporter HV045_08445 ENOG410903C (LipO)protein HV045_08450 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV045_08455 ENOG4105KZW UPF0381 protein HV045_08460 ENOG4105CHU acetyl-coa acetyltransferase HV045_08465 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV045_08470 ENOG4108BY2 phosphohistidine phosphatase HV045_08475 ENOG4108DG9 Smr protein MutS2 HV045_08480 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HV045_08490 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HV045_08495 ENOG4105EJ9 Membrane HV045_08500 ENOG4108BPE -transporting atpase HV045_08505 ENOG4105MH2 YfcL protein HV045_08510 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV045_08515 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV045_08540 ENOG4105F9N Major Facilitator Superfamily HV045_08545 ENOG4106WZ1 flagella biosynthesis regulator HV045_08550 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HV045_08555 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV045_08565 ENOG4105DQR SNARE associated Golgi HV045_08575 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV045_08580 ENOG4108S3P Sporulation domain protein HV045_08585 ENOG4105E96 Colicin v production protein HV045_08590 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV045_08595 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV045_08600 ENOG4105E89 ABC transporter HV045_08605 ENOG4105E89 ABC transporter HV045_08610 ENOG4105DSP amino acid AbC transporter HV045_08615 ENOG4106YG3 ABC transporter HV045_08620 ENOG4108JEH abc transporter atp-binding protein HV045_08625 ENOG4105D9U N-acetyltransferase HV045_08630 ENOG4105ECP epimerase HV045_08635 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV045_08640 ENOG4105CYM Glutathione S-transferase HV045_08645 ENOG4108SHQ Glutathione S-transferase HV045_08650 ENOG4108RE9 Phosphodiesterase HV045_08655 ENOG4105PTV Nudix Hydrolase HV045_08660 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV045_08665 ENOG4105C6K Malic enzyme HV045_08670 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV045_08675 ENOG4105PQ6 UPF0208 membrane protein HV045_08685 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV045_08690 ENOG4107QWE )-transporter HV045_08695 ENOG4105DK2 UPF0207 protein HV045_08700 ENOG4105CHM Aminotransferase HV045_08705 ENOG4107NQ8 LysR family Transcriptional regulator HV045_08710 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HV045_08715 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV045_08720 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV045_08725 ENOG4105GKE subunit e HV045_08730 ENOG4107QIZ NADH dehydrogenase HV045_08735 ENOG4108IEH NADH dehydrogenase subunit g HV045_08740 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HV045_08750 ENOG4107UFS subunit j HV045_08760 ENOG4105D65 subunit l HV045_08765 ENOG4105C8S subunit m HV045_08770 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV045_08780 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HV045_08785 ENOG4107YB6 acetyltransferase, (GNAT) family HV045_08790 ENOG4105TNS Conserved Protein HV045_08795 ENOG4105E4F Isochorismate synthase HV045_08815 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HV045_08820 ENOG4108IPT Naphthoate synthase HV045_08830 ENOG4105CEY Amp-dependent synthetase and ligase HV045_08880 ENOG4108UII YfaZ family HV045_08885 ENOG4108EWA cinA-like protein HV045_08890 ENOG4107258 Transcriptional regulator HV045_08900 ENOG4105CSP Major Facilitator Superfamily HV045_08920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV045_08925 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HV045_08930 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV045_08940 ENOG4105F9F transposase HV045_08950 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV045_08955 ENOG4105XPH Ferredoxin HV045_08960 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV045_08965 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV045_08970 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HV045_08975 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV045_08980 ENOG4105CHU acetyl-coa acetyltransferase HV045_08985 ENOG4105CRW Short chain fatty acid transporter HV045_08990 ENOG4107QNJ CoA-transferase subunit B HV045_08995 ENOG4107QP7 CoA-transferase subunit A HV045_09000 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV045_09005 ENOG4105BZU Histidine kinase HV045_09010 ENOG4105BZU Histidine kinase HV045_09015 ENOG41068CG regulatoR HV045_09020 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV045_09025 ENOG4105FCK Membrane HV045_09030 ENOG4105CJ2 (LipO)protein HV045_09035 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV045_09040 ENOG4105CF1 Alkylated DNA repair protein HV045_09045 ENOG4105IBP Cyclic peptide transporter HV045_09050 ENOG4105CJW magnesium transporter HV045_09055 ENOG4105CHH sulfate transporter HV045_09060 ENOG4105DWT malate dehydrogenase (quinone) HV045_09070 ENOG4108ZNS ferredoxin-type protein NapF HV045_09075 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HV045_09085 ENOG4108BGM Quinol dehydrogenase periplasmic component HV045_09090 ENOG4105GXZ Ferredoxin-type protein NapH HV045_09095 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HV045_09100 ENOG4105CUW cytochrome C-TYPE protein HV045_09105 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HV045_09110 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HV045_09115 ENOG41060IM Heme exporter protein HV045_09120 ENOG4105X3C heme exporter protein HV045_09125 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HV045_09130 ENOG4105DA4 cytochrome c-type biogenesis protein HV045_09135 ENOG4107QX9 Thiol disulfide interChange protein HV045_09140 ENOG4105KWW Biogenesis protein HV045_09145 ENOG4105WH1 Two component transcriptional regulator luxr family HV045_09155 ENOG4105E68 Sulfatase HV045_09160 ENOG4105PAN UPF0352 protein HV045_09165 ENOG4106V8H Nucleoid-associated protein HV045_09170 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HV045_09175 ENOG4105CFI type iii restriction protein res subunit HV045_09180 ENOG4105I08 Pseudouridine synthase HV045_09185 ENOG4105C2C drug resistance transporter, Bcr CflA HV045_09190 ENOG4105HG6 HV045_09195 ENOG4108JQ5 ABC transporter HV045_09200 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV045_09205 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV045_09210 ENOG4105E43 Extracellular solute-binding protein, family 5 HV045_09215 ENOG4105CXC rtn protein HV045_09220 ENOG4107TT5 NLP P60 protein HV045_09225 ENOG41076MN Phosphoesterase, PA-phosphatase related HV045_09230 ENOG4105CKI cobalamin synthesis protein HV045_09235 ENOG4105DEI Mannitol dehydrogenase HV045_09240 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HV045_09245 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV045_09250 ENOG4105CUW cytochrome C-TYPE protein HV045_09255 ENOG4108EM1 reductase HV045_09260 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HV045_09265 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HV045_09270 ENOG4105KRS Proteinase inhibitor HV045_09275 ENOG4105S8Q sugar efflux transporter HV045_09280 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV045_09285 ENOG4105DE4 1-phosphofructokinase HV045_09290 ENOG4105DM4 PTS System HV045_09295 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV045_09305 ENOG4107YNJ LysR family Transcriptional regulator HV045_09310 ENOG4105DD7 kinase (PfkB family HV045_09315 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HV045_09320 ENOG4105D9N nucleoside HV045_09325 ENOG4105DD7 kinase (PfkB family HV045_09330 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HV045_09335 ENOG4105HMI Membrane HV045_09340 ENOG4105DUM transcriptional regulator, lysR family HV045_09345 ENOG4108IQI permease HV045_09350 ENOG4105D05 Receptor HV045_09360 ENOG4105EUJ GTP cyclohydrolase i HV045_09365 ENOG4105DHF Membrane HV045_09370 ENOG41060NJ transcriptional regulator HV045_09380 ENOG4105C2J ABC transporter HV045_09385 ENOG4107SDZ Galactoside transport system permease protein mglC HV045_09390 ENOG4107SJI Dehydrogenase HV045_09395 ENOG4105BZ8 glutamate synthase HV045_09400 ENOG4105Y9N Membrane HV045_09405 ENOG4107GZ4 SanA protein HV045_09410 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) HV045_09415 ENOG41067MG lrgb family HV045_09420 ENOG4105VAW lrga family HV045_09445 ENOG4108RXX maleylacetoacetate isomerase HV045_09450 ENOG4105MSY salicylate hydroxylase HV045_09455 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV045_09460 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HV045_09465 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV045_09470 ENOG4105KHU inner membrane protein YohD HV045_09475 ENOG41069YE inner membrane protein yohC HV045_09480 ENOG41061WM D-Alanyl-D-Alanine HV045_09485 ENOG4105CXG d-lactate dehydrogenase HV045_09490 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV045_09495 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV045_09500 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV045_09505 ENOG4108IJ8 ABC transporter HV045_09510 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV045_09520 ENOG4108XDN Transcriptional regulator HV045_09525 ENOG4108HRK Histidine kinase HV045_09530 ENOG4108NEV two component transcriptional regulator, LytTR family HV045_09535 ENOG4108W15 Protein of unknown function (DUF1456) HV045_09540 ENOG4108YCW (LipO)protein HV045_09550 ENOG4105D1F ATP-binding protein HV045_09565 ENOG4108MQF Chaperone HV045_09570 ENOG4105CW0 outer membrane usher protein HV045_09580 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV045_09585 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HV045_09590 ENOG4105DWF phosphomethylpyrimidine kinase HV045_09595 ENOG4105FDP GntR family transcriptional regulator HV045_09600 ENOG4108TFM Kinase, PfkB family HV045_09605 ENOG4108KD5 ADP-ribosylation crystallin J1 HV045_09610 ENOG4105EAA nucleoside HV045_09615 ENOG4105EIE fructose-bisphosphate aldolase HV045_09620 ENOG4107TE5 Lipid kinase HV045_09625 ENOG4106TNF Periplasmic binding protein HV045_09630 ENOG4105DMR ABC, transporter HV045_09635 ENOG4105GBT ABC transporter HV045_09640 ENOG4106PMH Extracellular solute-binding protein family 3 HV045_09645 ENOG4105E5Z arginine transporter ATP-binding subunit HV045_09650 ENOG41064MM (LipO)protein HV045_09660 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV045_09665 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV045_09670 ENOG4105CGD Nad-dependent epimerase dehydratase HV045_09675 ENOG4105C5W Aldolase HV045_09680 ENOG4105C7K acetolactate synthase HV045_09690 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV045_09695 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV045_09705 ENOG4105DWU Membrane HV045_09710 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV045_09715 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV045_09720 ENOG4108MJ5 VirK protein HV045_09725 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV045_09735 ENOG4105VEQ Cold shock protein HV045_09740 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HV045_09745 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV045_09750 ENOG4105CFP Peptidase U32 HV045_09755 ENOG4105KWI UPF0339 protein HV045_09760 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV045_09765 ENOG4105EB3 Histidine kinase HV045_09770 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV045_09775 ENOG4105BZS acriflavin resistance protein HV045_09780 ENOG4105BZS acriflavin resistance protein HV045_09795 ENOG4105R8A Heat shock protein HV045_09800 ENOG4105D03 DNA-3-methyladenine glycosylase II HV045_09805 ENOG4105BZU Histidine kinase HV045_09815 ENOG4105DHP deoxycytidine triphosphate deaminase HV045_09820 ENOG4108GAE asmA family HV045_09825 ENOG4105EE5 Membrane protein terC HV045_09830 ENOG4105DAY polysaccharide export protein HV045_09835 ENOG4105KJF protein tyrosine phosphatase HV045_09840 ENOG4105D75 Capsular exopolysaccharide family HV045_09845 ENOG41090RK glycosyl transferase HV045_09850 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HV045_09855 ENOG4107RXY Glycosyl transferase HV045_09860 ENOG4108NYJ Colanic acid HV045_09865 ENOG4105ECJ Glycosyl Transferase HV045_09870 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HV045_09875 ENOG4105C0K Gdp-mannose 4,6-dehydratase HV045_09880 ENOG4105C30 Nad-dependent epimerase dehydratase HV045_09885 ENOG4105FGF GDP-mannose mannosyl hydrolase HV045_09890 ENOG4106CD9 glycosyl transferase group 1 HV045_09895 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV045_09900 ENOG4107QKV phosphomannomutase HV045_09905 ENOG4105D3Q Sugar transferase HV045_09910 ENOG4105PSV Polysaccharide Biosynthesis Protein HV045_09915 ENOG4105C74 pyruvyl transferase HV045_09920 ENOG4107T8Q Glycosyl transferase (Group 1 HV045_09925 ENOG4105G1A colanic acid biosynthesis protein HV045_09930 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV045_09955 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV045_10010 ENOG4105EKQ RNA-directed DNA polymerase HV045_10025 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV045_10030 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HV045_10040 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HV045_10045 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV045_10050 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV045_10055 ENOG4105CIH Imidazole acetol-phosphate transaminase HV045_10060 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HV045_10075 ENOG4107SRH Nad-dependent epimerase dehydratase HV045_10080 ENOG4105EQ1 Transcriptional regulator HV045_10090 ENOG4105CUB amino acid HV045_10095 ENOG4105CJB Exodeoxyribonuclease I HV045_10100 ENOG4108J2R molybdopterin oxidoreductase HV045_10105 ENOG4105QAX Iron-sulfur HV045_10110 ENOG4108NWD Cytochrome HV045_10115 ENOG4105DZ1 carboxypeptidase HV045_10120 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) HV045_10125 ENOG4105DR8 Membrane HV045_10135 ENOG4105JZC GHMP kinase HV045_10140 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV045_10145 ENOG4105KTW ethanolamine utilization protein HV045_10150 ENOG4105M3W utilization protein HV045_10160 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HV045_10170 ENOG4108EKI Dehydrogenase HV045_10180 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV045_10190 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HV045_10200 ENOG4105KNY Microcompartments protein HV045_10210 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HV045_10215 ENOG4108ZFT Dehydratase small subunit HV045_10220 ENOG4105YCI dehydratase medium subunit HV045_10225 ENOG4105DMB glycerol dehydratase HV045_10230 ENOG4105EHR propanediol utilization protein pduB HV045_10235 ENOG4105KNY Microcompartments protein HV045_10240 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV045_10250 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV045_10255 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) HV045_10260 ENOG41081F0 Precorrin-8x methylmutase HV045_10265 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) HV045_10270 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase HV045_10275 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase HV045_10280 ENOG4105CIA precorrin-4 C(11)-methyltransferase HV045_10285 ENOG4108P62 biosynthesis protein (CbiG) HV045_10290 ENOG4105E4R Precorrin-3B C17-methyltransferase HV045_10295 ENOG4105QUC reductase HV045_10300 ENOG4107PPM cobalt chelatase HV045_10305 ENOG4105DVK Precorrin-2 c20-methyltransferase HV045_10310 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV045_10315 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) HV045_10320 ENOG4108V4M Cobalt abc transporter HV045_10330 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) HV045_10335 ENOG4108YZT Adenosylcobinamide kinase HV045_10340 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HV045_10345 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HV045_10350 ENOG4108PXI ErfK YbiS YcfS YnhG HV045_10360 ENOG4107RCV ABC transporter, permease HV045_10480 ENOG4105C4R Atp-dependent dna helicase HV045_10525 ENOG4105EST Metal Dependent Phosphohydrolase HV045_10530 ENOG4105DVF Cytosine-specific methyltransferase HV045_10535 ENOG41090BB DNA mismatch endonuclease (vsr) HV045_10540 ENOG4105FDR Membrane HV045_10545 ENOG4105CKW Inner membrane protein yedI HV045_10550 ENOG4105VNZ cytoplasmic protein HV045_10555 ENOG4105YX3 cellular response to acidity HV045_10560 ENOG4105VZF DsrB protein HV045_10565 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HV045_10570 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV045_10575 ENOG4105VS8 Flagellar biosynthetic protein fliq HV045_10580 ENOG4105CN7 Flagellar biosynthetic protein FliP HV045_10585 ENOG4105K0P flagellar biosynthesis protein HV045_10590 ENOG4105DD5 Flagellar motor switch protein HV045_10595 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV045_10600 ENOG4107ZI8 flagellar basal body-associated protein flil HV045_10605 ENOG4105WF4 Flagellar hook-length control protein HV045_10610 ENOG4105GSA Flagellar export protein flij HV045_10615 ENOG4108JIR Flagellum-specific ATP synthase HV045_10620 ENOG41090PJ Flagellar assembly protein HV045_10625 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV045_10630 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HV045_10645 ENOG41066VF YeeE YedE family protein HV045_10650 ENOG4105JCU Inherit from NOG: (Lipo)protein HV045_10655 ENOG4105E5K Alpha-amylase HV045_10665 ENOG4105MQ3 flagellar protein FliS HV045_10670 ENOG4105DTS flagellar hook-associated HV045_10685 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV045_10690 ENOG4108M9K flagella biosynthesis protein FliZ HV045_10695 ENOG4105EAB amino acid AbC transporter HV045_10700 ENOG4105K6H D-cysteine desulfhydrase HV045_10705 ENOG4105E5Q amino acid AbC transporter HV045_10710 ENOG4105CDA abc transporter atp-binding protein HV045_10715 ENOG4105VJY transcriptional regulator HV045_10720 ENOG4105XVG cytoplasmic protein HV045_10725 ENOG4105WH1 Two component transcriptional regulator luxr family HV045_10730 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HV045_10790 ENOG4108MXD gtp-binding protein HV045_10840 ENOG4105F2I Transposase HV045_10855 ENOG4105EKQ RNA-directed DNA polymerase HV045_10865 ENOG41060EU Cold shock-like protein HV045_10870 ENOG4105VEQ Cold shock protein HV045_10890 ENOG4105CAU Arsenical resistance protein, ArsH HV045_10895 ENOG4105KBH arsR family transcriptional regulator HV045_10925 ENOG4108KS2 transglutaminase domain protein HV045_10935 ENOG410681U heavy metal transport detoxification protein HV045_10940 ENOG4106RHG Yeca family HV045_10945 ENOG4105E0U tyrosine-specific transport protein HV045_10950 ENOG4105VVZ metal-binding protein HV045_10955 ENOG41090A1 ferritin HV045_10960 ENOG4105P23 (LipO)protein HV045_10970 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV045_10975 ENOG4105N4N Protein of unknown function (DUF2766) HV045_10980 ENOG4108UEC Ferritin-like protein HV045_10990 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV045_10995 ENOG4105C2J ABC transporter HV045_11000 ENOG4105CNN ABC, transporter HV045_11005 ENOG4108K4C ec 3.1.3.12 HV045_11010 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HV045_11015 ENOG4108VA4 Universal stress protein HV045_11025 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HV045_11030 ENOG4107RD7 Flagellar Motor Protein, MotA HV045_11035 ENOG4105ER2 Ompa motb domain protein HV045_11045 ENOG4108V3W Chemotaxis protein, CheW HV045_11050 ENOG4107QJT sodium dicarboxylate symporter HV045_11055 ENOG4105C8Q Methyl-accepting chemotaxis HV045_11060 ENOG4105C8Q Methyl-accepting chemotaxis HV045_11065 ENOG4105BZU Histidine kinase HV045_11070 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HV045_11075 ENOG4108VYJ response regulator receiver protein HV045_11080 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HV045_11085 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV045_11100 ENOG4105D00 flagellar biosynthetic protein flhB HV045_11105 ENOG4105D7B Flagellar biosynthesis protein flha HV045_11110 ENOG4105IRD Flagellar protein FlhE HV045_11115 ENOG4105CT4 transporter HV045_11120 ENOG4105F5H Glycosyl Hydrolase Family 88 HV045_11130 ENOG4105C75 arginyL-tRNA synthetase HV045_11135 ENOG4106ZCM YecM protein HV045_11140 ENOG4106N3A copper homeostasis protein cutc HV045_11145 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) HV045_11155 ENOG4105WJG Glutathione HV045_11160 ENOG41081XQ Conserved Protein HV045_11165 ENOG4105D3W isochorismatase HV045_11170 ENOG4105C9M aspartyl-trna synthetase HV045_11175 ENOG4108TIT dATP pyrophosphohydrolase HV045_11180 ENOG4105CDY transcriptional regulatory protein HV045_11185 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HV045_11195 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HV045_11200 ENOG4107QTF adenylosuccinate lyase HV045_11210 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HV045_11225 ENOG4108HMX isocitrate dehydrogenase (NADP) HV045_11230 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV045_11235 ENOG4105J4Q Transcriptional regulator HV045_11240 ENOG4105TIK HV045_11245 ENOG4107BVS HV045_11250 ENOG4105Q3Y exported protein HV045_11265 ENOG4105CJN penicillin-binding protein HV045_11270 ENOG4105DHI Methyltransferase HV045_11280 ENOG4108NK4 UPF0266 membrane protein HV045_11285 ENOG4105F3R pts system mannose fructose sorbose family iid HV045_11290 ENOG4105ETZ PTS System HV045_11295 ENOG4105DAS pts system HV045_11300 ENOG4105EE5 Membrane protein terC HV045_11305 ENOG4107XTP (EAL) domain protein HV045_11310 ENOG4105EJQ L-serine dehydratase HV045_11320 ENOG4105CRQ synthase (Component I) HV045_11325 ENOG4105X5C UPF0181 protein HV045_11330 ENOG4105M4H endoribonuclease L-psp HV045_11335 ENOG4105DVT helicase HV045_11340 ENOG41072GX Peptidase M22 Glycoprotease HV045_11345 ENOG4105Y4Z Outer Membrane Lipoprotein HV045_11350 ENOG4105CEY Amp-dependent synthetase and ligase HV045_11355 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV045_11360 ENOG4105E3J oxidoreductase HV045_11365 ENOG4105DVW rieske (2Fe-2S) HV045_11370 ENOG4105C94 Transporter HV045_11375 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV045_11380 ENOG4105EJC lysr family transcriptional regulator HV045_11390 ENOG4107QMS site-determining protein HV045_11400 ENOG4105VNG YcgL domain-containing protein HV045_11405 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV045_11410 ENOG4108ZZ3 UPF0260 protein HV045_11420 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV045_11435 ENOG4105ED1 spovr family HV045_11440 ENOG4105MWK D-amino acid dehydrogenase, small subunit HV045_11445 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV045_11455 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV045_11465 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HV045_11480 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV045_11485 ENOG4108BSC Methyltransferase HV045_11490 ENOG4105E0A ABC, transporter HV045_11495 ENOG4105EHG Permease protein HV045_11500 ENOG4105S10 periplasmic binding protein HV045_11505 ENOG4105E53 ec 3.2.1.28 HV045_11515 ENOG4108UTZ Dihydroxyacetone kinase HV045_11520 ENOG4105CMT Dihydroxyacetone kinase HV045_11525 ENOG4105D82 Glutamate dehydrogenase HV045_11550 ENOG4108XDN Transcriptional regulator HV045_11555 ENOG4105BZU Histidine kinase HV045_11560 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV045_11565 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HV045_11575 ENOG410738I uncharacterized protein ymgC HV045_11585 ENOG4105CGD Nad-dependent epimerase dehydratase HV045_11590 ENOG4105EQ2 LysR family Transcriptional regulator HV045_11595 ENOG4107SET aldo keto reductase HV045_11605 ENOG4105C4X radical SAM domain protein HV045_11625 ENOG4105QEK Transcriptional regulator HV045_11630 ENOG4105VG5 Membrane HV045_11670 ENOG4105GR3 Histidine kinase HV045_11680 ENOG4105ENX hydrolase HV045_11685 ENOG4105DVF Cytosine-specific methyltransferase HV045_11730 ENOG4105ZUU Transcriptional regulator HV045_11745 ENOG4108XS9 dna repair protein HV045_11750 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV045_11815 ENOG4105DFP Integrase HV045_11820 ENOG4105C3G gtp-binding protein HV045_11830 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV045_11835 ENOG4105CFH Aspartokinase HV045_11840 ENOG4108JPW Aminotransferase HV045_11845 ENOG4105DY8 decarboxylase HV045_11850 ENOG4105CHH sulfate transporter HV045_11855 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV045_11865 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HV045_11870 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HV045_11875 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HV045_11880 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HV045_11885 ENOG4108YY7 Invasion gene expression up-regulator SirB HV045_11890 ENOG41063JG Transcriptional regulator HV045_11900 ENOG4105EWV Sodium calcium exchanger membrane region HV045_11905 ENOG4105WS7 Cation transport regulator HV045_11910 ENOG4108NH8 Cation transport protein HV045_11920 ENOG41090EX DsrE family HV045_11925 ENOG4105ID0 Putative invasin HV045_11930 ENOG4105WH1 Two component transcriptional regulator luxr family HV045_11935 ENOG4105BZU Histidine kinase HV045_11940 ENOG4105DQQ Major facilitator superfamily MFS_1 HV045_11945 ENOG4105CRU nitrate reductase, alpha subunit HV045_11950 ENOG4108IUE nitrate reductase beta subunit HV045_11955 ENOG4105R3A Nitrate reductase HV045_11960 ENOG41076YT nitrate reductase, gamma subunit HV045_11980 ENOG4105CIY formyltetrahydrofolate deformylase HV045_11990 ENOG4105D78 K07001 NTE family protein HV045_11995 ENOG4105I93 response regulator HV045_12000 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV045_12010 ENOG4107104 thymidine kinase HV045_12015 ENOG4105C0A alcohol dehydrogenase HV045_12020 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV045_12025 ENOG4107QSI ABC, transporter HV045_12030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV045_12035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV045_12040 ENOG4105C3U ABC transporter HV045_12045 ENOG4108JQ7 (ABC) transporter HV045_12050 ENOG4105EYW Ion transport protein HV045_12060 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HV045_12070 ENOG4105K9H YciI-like protein HV045_12075 ENOG410822N TonB family HV045_12080 ENOG4105NAU thioesterase Superfamily protein HV045_12085 ENOG4107835 probably involved in intracellular septation (By similarity) HV045_12090 ENOG4108S3I UPF0259 membrane protein HV045_12095 ENOG4105EIF outer membrane protein W HV045_12105 ENOG4105BZU Histidine kinase HV045_12110 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HV045_12115 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HV045_12120 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV045_12125 ENOG4108EFP Anthranilate synthase component II HV045_12130 ENOG4105CRQ synthase (Component I) HV045_12140 ENOG4105DB7 PHP domain protein HV045_12145 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV045_12150 ENOG4105FE9 pseudouridine synthase HV045_12155 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV045_12160 ENOG4105UBK short-chain dehydrogenase reductase HV045_12165 ENOG4105ERU peptidase HV045_12170 ENOG4105RKX Protein of unknown function (DUF2498) HV045_12175 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV045_12180 ENOG4107R11 Transcriptional regulator HV045_12195 ENOG4107QM5 aconitate hydratase HV045_12205 ENOG4105EYK Phosphatidylglycerophosphatase B HV045_12210 ENOG4105Q4A inner membrane protein yciS HV045_12215 ENOG4105CFV Tetratricopeptide repeat protein HV045_12225 ENOG4108ZJT translation initiation factor, Sui1 HV045_12235 ENOG4105N2W Transcriptional regulator HV045_12240 ENOG4106BSC UPF0509 protein HV045_12245 ENOG4105BZU Histidine kinase HV045_12255 ENOG4105Q4T oxidoreductase HV045_12260 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV045_12275 ENOG4108JQ2 peptide transport system atp-binding protein HV045_12280 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV045_12285 ENOG4108EU3 peptide transport system, permease HV045_12290 ENOG4108EKA peptide transport system, permease HV045_12295 ENOG4108J59 Extracellular solute-binding protein, family 5 HV045_12300 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV045_12305 ENOG4105E51 psp operon transcriptional activator HV045_12310 ENOG41087YS Phage shock protein A HV045_12315 ENOG4105YYT phage shock protein B HV045_12320 ENOG4105FM1 phage shock protein C HV045_12325 ENOG4105NNG Peripheral inner membrane phage-shock protein HV045_12330 ENOG4107QW3 Sucrose phosphorylase HV045_12335 ENOG4105WEM extracellular solute-binding protein HV045_12340 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HV045_12345 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HV045_12350 ENOG4107RRD Dehydrogenase HV045_12355 ENOG4107TYA transient receptor potential locus HV045_12360 ENOG4105CK5 oxidoreductase HV045_12365 ENOG4105C71 hydrolase family 65, central catalytic HV045_12370 ENOG4107URF beta-phospho-glucomutase HV045_12380 ENOG4107EFV Outer membrane protein G HV045_12385 ENOG4105FKQ transcriptional regulator HV045_12390 ENOG4105K8Z Phage shock protein HV045_12395 ENOG4105CM6 amino acid regulated cytosolic protein HV045_12400 ENOG4106K28 UPF0283 membrane protein HV045_12410 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV045_12415 ENOG4107S8C mandelate racemase muconate lactonizing HV045_12420 ENOG4105KXI murein peptide amidase A HV045_12425 ENOG4107QSI ABC, transporter HV045_12430 ENOG4105MVE transcriptional regulator HV045_12435 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HV045_12450 ENOG4105D64 Mechanosensitive ion channel HV045_12455 ENOG4105S5I Membrane HV045_12460 ENOG4105Q9Y Universal stress protein HV045_12465 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV045_12470 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV045_12475 ENOG4108DG9 Smr protein MutS2 HV045_12480 ENOG4105BZU Histidine kinase HV045_12485 ENOG4105BZU Histidine kinase HV045_12490 ENOG4105C8Q Methyl-accepting chemotaxis HV045_12505 ENOG4105C1J atp-dependent rna helicase HV045_12510 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HV045_12515 ENOG4108RW8 Universal stress protein F HV045_12525 ENOG4105FCK Membrane HV045_12530 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV045_12535 ENOG4105IKK cytoplasmic protein HV045_12540 ENOG41090X5 Heat shock protein hslJ HV045_12545 ENOG4105C5I Dehydrogenase HV045_12555 ENOG410689M (LipO)protein HV045_12560 ENOG4105WXT Conserved Protein HV045_12565 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HV045_12570 ENOG4108HPI phosphatidate Cytidylyltransferase HV045_12580 ENOG4105E8V Alpha Beta Hydrolase Fold protein HV045_12585 ENOG41077RS Phosphatase HV045_12600 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HV045_12605 ENOG4105CQ7 ATP-dependent helicase HV045_12610 ENOG4107DB1 DUF218 domain HV045_12615 ENOG4105C26 Dehydrogenase HV045_12620 ENOG4105CPW cytochrome b561 HV045_12625 ENOG4105KT5 UmuD protein HV045_12630 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV045_12635 ENOG4105D6F Phosphatase HV045_12650 ENOG4105C8Q Methyl-accepting chemotaxis HV045_12655 ENOG4105DDW LysR family Transcriptional regulator HV045_12665 ENOG4105E32 cytoplasmic protein HV045_12675 ENOG4105Z2P Protein of unknown function (DUF465) HV045_12680 ENOG4108Z9I -acetyltransferase HV045_12685 ENOG4107WE3 acetyltransferase YdcK HV045_12710 ENOG41088CC tellurite resistance protein tehB HV045_12715 ENOG4108KKZ (LipO)protein HV045_12720 ENOG4105DWP Membrane HV045_12730 ENOG4105DKK Benzoate HV045_12735 ENOG4108JCI Transcriptional regulator HV045_12740 ENOG4105CFP Peptidase U32 HV045_12745 ENOG4105RR0 Protein of unknown function (DUF2554) HV045_12755 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV045_12760 ENOG4105C4M (Ubiquinol oxidase) subunit I HV045_12770 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HV045_12775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV045_12780 ENOG4107TYH extracellular solute-binding protein family 1 HV045_12785 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV045_12790 ENOG4105D81 ABC transporter, permease HV045_12795 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HV045_12800 ENOG4105C26 Dehydrogenase HV045_12805 ENOG4105C2C drug resistance transporter, Bcr CflA HV045_12820 ENOG410654E Membrane HV045_12840 ENOG4105DEF Extracellular solute-binding protein, family 5 HV045_12845 ENOG4105R71 cytoplasmic protein HV045_12850 ENOG4108T9Y Inner membrane protein ydcZ HV045_12855 ENOG4108Z7F N-acetyltransferase HV045_12865 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV045_12870 ENOG4105CHB tonB-dependent Receptor HV045_12875 ENOG4108NS2 receptor HV045_12880 ENOG4105SUV lipoprotein YgdR HV045_12885 ENOG4105C85 amino acid HV045_12895 ENOG4105F2I Transposase HV045_12900 ENOG4105DEN Luciferase family HV045_12915 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HV045_12930 ENOG4105CDA abc transporter atp-binding protein HV045_12935 ENOG4108N27 Glutathione S-transferase HV045_12940 ENOG4105DJB Major Facilitator Superfamily HV045_12945 ENOG4105DIA mandelate racemase muconate lactonizing HV045_12950 ENOG4105ETE Transcriptional regulator (LacI family HV045_12960 ENOG4108MEJ flavin reductase domain protein HV045_12965 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV045_12970 ENOG4105JAB phenazine biosynthesis protein, phzf family HV045_12975 ENOG4105D0D Nitrate reductase 2, gamma subunit HV045_12980 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HV045_12985 ENOG4108IUE nitrate reductase beta subunit HV045_12990 ENOG4105CRU nitrate reductase, alpha subunit HV045_12995 ENOG4107QND Nitrite extrusion protein HV045_13030 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV045_13035 ENOG4108MG3 formate dehydrogenase HV045_13060 ENOG4107R1I NAD-dependent malic enzyme HV045_13065 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HV045_13070 ENOG4108Z9K Osmotically inducible protein HV045_13075 ENOG4105DTD Dehydrogenase HV045_13080 ENOG4105CY2 Citrate transporter HV045_13090 ENOG4105CHU acetyl-coa acetyltransferase HV045_13095 ENOG4107QNJ CoA-transferase subunit B HV045_13100 ENOG4107QP7 CoA-transferase subunit A HV045_13105 ENOG4105DUM transcriptional regulator, lysR family HV045_13110 ENOG4107H6U ABC transporter HV045_13115 ENOG4105C3U ABC transporter HV045_13120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV045_13125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV045_13130 ENOG4105DEF Extracellular solute-binding protein, family 5 HV045_13135 ENOG4108UQS dipeptidase HV045_13145 ENOG4105XXV Acid-resistance protein HV045_13150 ENOG4105C8Q Methyl-accepting chemotaxis HV045_13155 ENOG4105F32 YngK protein HV045_13160 ENOG4105VYA Uncharacterized conserved protein (DUF2132) HV045_13190 ENOG4105FFC UPF0187 protein HV045_13205 ENOG4105M0C cytoplasmic protein HV045_13210 ENOG4105CSV Glutaminase HV045_13215 ENOG4105C26 Dehydrogenase HV045_13220 ENOG4105EGI Transcriptional regulator HV045_13225 ENOG4105F27 Major Facilitator HV045_13235 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV045_13240 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV045_13245 ENOG4106DNR multiple antibiotic resistance protein HV045_13250 ENOG4108594 Permease of the drug metabolite transporter HV045_13255 ENOG4105E5W Transporter HV045_13260 ENOG4108IV0 ABC, transporter HV045_13270 ENOG4105CNN ABC, transporter HV045_13275 ENOG4105C32 Amino acid ABC transporter (Permease) HV045_13290 ENOG4105DGW oligopeptidase A HV045_13295 ENOG4105EMU Dehydrogenase HV045_13300 ENOG4107XBN GntR Family Transcriptional Regulator HV045_13305 ENOG41061EV selenium-binding protein YdfZ HV045_13310 ENOG4105DEI Mannitol dehydrogenase HV045_13320 ENOG4105CPQ Dehydrogenase HV045_13325 ENOG4105CXK mandelate racemase muconate lactonizing HV045_13330 ENOG4105KK4 UPF0060 membrane protein HV045_13335 ENOG4105M5Q UPF0482 protein HV045_13340 ENOG4108MK9 spermidine N(1)-acetyltransferase HV045_13350 ENOG4105KBG Protein of unknown function (DUF1161) HV045_13355 ENOG4107QY8 reductase HV045_13360 ENOG4105QAX Iron-sulfur HV045_13365 ENOG4107KGK dmso reductase anchor subunit HV045_13370 ENOG4108NEM leader-binding protein dmsD HV045_13375 ENOG4105CMQ Chloride channel HV045_13380 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV045_13385 ENOG4105DAG ROK family HV045_13390 ENOG4106NZI LysR family Transcriptional regulator HV045_13395 ENOG4105D94 Major Facilitator Superfamily HV045_13405 ENOG4105ES5 Histidine kinase HV045_13410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV045_13420 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HV045_13425 ENOG4105CTD carboxy-peptidase HV045_13435 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV045_13445 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) HV045_13450 ENOG4105DSF transport protein HV045_13455 ENOG4105C2C drug resistance transporter, Bcr CflA HV045_13460 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV045_13465 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV045_13470 ENOG4105C5D exported protein HV045_13475 ENOG4105D5Q Arginine ornithine antiporter HV045_13480 ENOG410642E Short chain dehydrogenase HV045_13485 ENOG4105RA2 Membrane HV045_13490 ENOG4107EXC regulatoR HV045_13515 ENOG4105JJR Histidine kinase HV045_13520 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HV045_13525 ENOG4105C9Q fumarate hydratase class II HV045_13530 ENOG4107GFK fumarate HV045_13535 ENOG4105EIP mannose-6-phosphate isomerase HV045_13540 ENOG4106J39 exported protein HV045_13545 ENOG4107P2S Transcriptional regulator HV045_13550 ENOG4105CI1 PTS System HV045_13555 ENOG4105C87 Aminotransferase class I and II HV045_13565 ENOG4105D9R oxidoreductase HV045_13570 ENOG4106C6R beta-lactam resistance protein HV045_13575 ENOG4105QZ5 OriC-binding nucleoid-associated protein HV045_13580 ENOG4105M9B inner membrane protein ydgK HV045_13590 ENOG4108R3D Electron transport complex HV045_13600 ENOG4105D6A Electron transport complex HV045_13605 ENOG4108UQQ Electron transport complex HV045_13610 ENOG4105DZB Electron transport complex HV045_13615 ENOG4105CSM endonuclease III HV045_13620 ENOG4105DUX Transporter HV045_13625 ENOG4108K3A Glutathione S-transferase HV045_13630 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV045_13635 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HV045_13645 ENOG410642K Lysozyme inhibitor HV045_13655 ENOG4108XTF Outer Membrane Lipoprotein HV045_13670 ENOG4105Y49 secretion protein, HlyD family HV045_13675 ENOG4105DSW Fusaric acid resistance protein HV045_13680 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV045_13685 ENOG4107RGM aldo keto reductase HV045_13690 ENOG4105XZD Fe-S protein HV045_13695 ENOG4108WUH Transcriptional regulator, TetR family HV045_13700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV045_13705 ENOG4108UYE Lactoylglutathione lyase HV045_13710 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HV045_13715 ENOG4105M2J Glutaredoxin HV045_13720 ENOG4105K4H Nlp p60 protein HV045_13725 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV045_13730 ENOG4105F27 Major Facilitator HV045_13740 ENOG4105ETE Transcriptional regulator (LacI family HV045_13745 ENOG4105F52 Transcriptional regulator HV045_13750 ENOG4105CZQ inner membrane transport protein YdhC HV045_13760 ENOG4108R6K riboflavin synthase, subunit alpha HV045_13770 ENOG4105D3G Pseudouridine synthase HV045_13775 ENOG4105JAB phenazine biosynthesis protein, phzf family HV045_13780 ENOG4105N0V mono-oxygenase ydhR HV045_13785 ENOG4105KME endoribonuclease L-psp HV045_13805 ENOG4105BZU Histidine kinase HV045_13810 ENOG4107SEY Conserved Protein HV045_13815 ENOG4105F4G Membrane HV045_13835 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HV045_13850 ENOG4105CBP Major Facilitator HV045_13865 ENOG4105VSH 4-oxalocrotonate tautomerase HV045_13875 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV045_13895 ENOG4105EQ2 LysR family Transcriptional regulator HV045_13900 ENOG4105ENX hydrolase HV045_13905 ENOG4107RTG Major Facilitator superfamily HV045_13925 ENOG4108V06 Glutathione peroxidase HV045_13940 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein HV045_13945 ENOG4108W0P ABC transporter HV045_13950 ENOG4105EHG Permease protein HV045_13955 ENOG4105S10 periplasmic binding protein HV045_13960 ENOG4108JPW Aminotransferase HV045_13985 ENOG4105C26 Dehydrogenase HV045_14000 ENOG4105C85 amino acid HV045_14010 ENOG4105CT1 (ABC) transporter HV045_14020 ENOG4105E5Q amino acid AbC transporter HV045_14025 ENOG4105DRP amino acid AbC transporter HV045_14030 ENOG4108Y7C Conserved Protein HV045_14035 ENOG4108NWD Cytochrome HV045_14040 ENOG4108393 oxidoreductase Fe-S subunit HV045_14045 ENOG4105JVW HV045_14050 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HV045_14055 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HV045_14060 ENOG4105RFR Protein of unknown function (DUF2767) HV045_14065 ENOG4108ZXC Two component transcriptional regulator, luxr family HV045_14070 ENOG4106AFQ Histidine kinase HV045_14075 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV045_14080 ENOG4106WHD Tetrathionate reductase HV045_14085 ENOG4105DB1 molybdopterin oxidoreductase HV045_14090 ENOG4105D01 (LipO)protein HV045_14095 ENOG4108UMI ABC transporter, permease HV045_14105 ENOG4105CA9 Pyruvate kinase HV045_14115 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV045_14125 ENOG4105C9B Cysteine desulfurase HV045_14130 ENOG4105JRK feS assembly protein SufD HV045_14135 ENOG4105C3K feS assembly ATPase SufC HV045_14140 ENOG4105DIW FeS assembly protein SUFB HV045_14145 ENOG4108Z4V iron-sulfur cluster assembly HV045_14160 ENOG4105EXG Transcriptional regulator HV045_14170 ENOG410671Z uncharacterized protein ydiH HV045_14175 ENOG4105KA0 thioesterase Superfamily protein HV045_14180 ENOG4105CQB FAD linked oxidase domain protein HV045_14185 ENOG4105IPI Membrane HV045_14195 ENOG4105SUA Ydil protein HV045_14200 ENOG4105EMV Major Facilitator HV045_14205 ENOG4105EMV Major Facilitator HV045_14220 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HV045_14225 ENOG4105C1G acyl-Coa dehydrogenase HV045_14230 ENOG4105W4W Transcriptional regulator HV045_14235 ENOG4105CV7 Electron transfer flavoprotein HV045_14240 ENOG4105C10 Electron transfer flavoprotein HV045_14245 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV045_14250 ENOG41090P5 ferredoxin-like protein HV045_14255 ENOG4105CEY Amp-dependent synthetase and ligase HV045_14260 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV045_14270 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV045_14280 ENOG4107ENK receptor HV045_14285 ENOG4106QJH hemin transport protein HV045_14290 ENOG4107R4I Periplasmic binding protein HV045_14295 ENOG4105EHG Permease protein HV045_14300 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV045_14315 ENOG4108QBX (LipO)protein HV045_14320 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HV045_14325 ENOG4108V06 Glutathione peroxidase HV045_14340 ENOG4108RVA ribokinase HV045_14345 ENOG4108NFH Sugar hydrolase HV045_14355 ENOG4105D9N nucleoside HV045_14360 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV045_14385 ENOG41082NX 50s ribosomal protein l35 HV045_14390 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV045_14405 ENOG4108NE3 Salt-induced outer membrane protein HV045_14410 ENOG4105DE4 1-phosphofructokinase HV045_14420 ENOG4107PN8 YfeABCD locus regulator HV045_14425 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV045_14430 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV045_14435 ENOG4108ETY sodium dicarboxylate symporter HV045_14440 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HV045_14445 ENOG4105CH6 catalase HV045_14450 ENOG410901P UPF0249 protein HV045_14455 ENOG4105F8D glycoside hydrolase family 4 HV045_14460 ENOG4105EZV Transcriptional regulator HV045_14465 ENOG4105VCP PTS System HV045_14470 ENOG4105CK1 PTS System HV045_14475 ENOG4105VZJ PTS System HV045_14480 ENOG4105KKI DNA-binding transcriptional activator OsmE HV045_14485 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HV045_14490 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV045_14495 ENOG41090B9 response to stress HV045_14500 ENOG4108SPG Periplasmic Protein HV045_14515 ENOG4105C26 Dehydrogenase HV045_14525 ENOG4105C8Y Acetylornithine aminotransferase HV045_14530 ENOG4105CGK Exodeoxyribonuclease III HV045_14535 ENOG4108RSN SNARE associated Golgi HV045_14540 ENOG4108N5C SNARE associated Golgi protein-related protein HV045_14545 ENOG4105VNH ABC transporter solute-binding protein HV045_14550 ENOG4105CXZ ABC transporter, permease HV045_14555 ENOG4108VGW abc transporter atp-binding protein HV045_14560 ENOG4107RM6 sulfurtransferase HV045_14565 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV045_14570 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV045_14575 ENOG4105M6F mutator MutT protein HV045_14580 ENOG4105MTM Protein of unknown function (DUF1496) HV045_14585 ENOG4105D82 Glutamate dehydrogenase HV045_14590 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV045_14595 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HV045_14600 ENOG41069NU Nitroreductase HV045_14605 ENOG4105D07 Signal peptide peptidase, SppA HV045_14610 ENOG4105HDK L-asparaginase HV045_14615 ENOG4108RWI nicotinamidase HV045_14625 ENOG4105N1F Hnh endonuclease HV045_14630 ENOG4105VUT cytoplasmic protein HV045_14640 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV045_14645 ENOG4105DSB aldose 1-epimerase HV045_14650 ENOG4105CV8 reductase HV045_14665 ENOG4105GNX MltA-interacting MipA family protein HV045_14670 ENOG4105CYN Serine protein kinase HV045_14680 ENOG4105EQK -acetyltransferase HV045_14690 ENOG4105DVA methyltransferase HV045_14695 ENOG4108KHP Diguanylate cyclase HV045_14700 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV045_14710 ENOG4105R1U AraC Family Transcriptional Regulator HV045_14715 ENOG4105DJ2 Major Facilitator Superfamily HV045_14720 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HV045_14725 ENOG4105K78 MarR family Transcriptional regulator HV045_14730 ENOG4105UCG Domain of unknown function (DUF333) HV045_14735 ENOG410620I Diguanylate cyclase HV045_14740 ENOG4106G4W HV045_14750 ENOG4105Y3U Transglycosylase-associated protein HV045_14755 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HV045_14765 ENOG4105YP6 Domain of unknown function (DUF1869) HV045_14770 ENOG4108YS1 cytoplasmic protein HV045_14775 ENOG4108NIW Leucine export protein LeuE HV045_14780 ENOG4108MEK Metal-binding protein YodA HV045_14785 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV045_14795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV045_14805 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HV045_14810 ENOG4105D05 Receptor HV045_14815 ENOG4105D0M Protease HtpX homolog HV045_14820 ENOG4105CN1 protease HV045_14825 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HV045_14830 ENOG4108ZGC gaf domain protein HV045_14835 ENOG4105H2K paraquat-inducible protein a HV045_14840 ENOG4105DY2 Paraquat-inducible protein b HV045_14845 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HV045_14850 ENOG4105WT8 Protein of unknown function (DUF1480) HV045_14855 ENOG4105UVW uncharacterized protein yebW HV045_14860 ENOG4108R1E Serine threonine protein phosphatase 1 HV045_14875 ENOG4108RAV Conserved protein HV045_14880 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV045_14885 ENOG4105KT5 UmuD protein HV045_14890 ENOG4105Y50 Virulence Protein HV045_15100 ENOG4105MPK DNA polymerase III subunit theta HV045_15140 ENOG4105JBR DNA replication protein HV045_15170 ENOG4105F2I Transposase HV045_15210 ENOG41076J9 exonuclease VIII HV045_15235 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 HV045_15240 ENOG4108I1J Integrase HV045_15245 ENOG4105NKT exported protein HV045_15250 ENOG4108PNC copper resistance HV045_15255 ENOG4105FXM Copper resistance protein HV045_15260 ENOG4105MPK DNA polymerase III subunit theta HV045_15265 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV045_15270 ENOG4105UMD exodeoxyribonuclease X HV045_15275 ENOG4105CUG Oligopeptidase b HV045_15280 ENOG4108Q2J Inner membrane protein YebE HV045_15290 ENOG4105X2V dna damage-inducible protein HV045_15295 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HV045_15300 ENOG4108UHU Aldolase HV045_15305 ENOG4105C01 Dihydroxy-acid dehydratase HV045_15310 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV045_15315 ENOG4106KNT transcriptional regulator HV045_15320 ENOG4105CA9 Pyruvate kinase HV045_15325 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV045_15330 ENOG4105DR5 peptidase HV045_15335 ENOG4105NXV High-affinity zinc uptake system protein HV045_15345 ENOG4105FAV ABC, transporter HV045_15355 ENOG4105F9F transposase HV045_15380 ENOG4108W9T type 1 fimbriae regulatory protein HV045_15390 ENOG4108W9T type 1 fimbriae regulatory protein HV045_15405 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV045_15415 ENOG4105EZE Cupin 4 family protein HV045_15420 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HV045_15435 ENOG4105W3V DNA-binding, transcriptional regulator HV045_15440 ENOG4105E2V Glycosyltransferase 36 HV045_15450 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV045_15455 ENOG4106IAW HV045_15475 ENOG4105DR8 Membrane HV045_15490 ENOG4105VEQ Cold shock protein HV045_15505 ENOG4105D38 putrescine abc transporter HV045_15510 ENOG4108HM4 ABC transporter HV045_15515 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV045_15525 ENOG4105D60 lipoprotein releasing system transmembrane protein HV045_15530 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV045_15535 ENOG4105D60 lipoprotein releasing system transmembrane protein HV045_15540 ENOG4105IQC Inner membrane protein YcfT HV045_15545 ENOG4108JA2 transcriptioN-repair coupling factor HV045_15550 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV045_15555 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV045_15560 ENOG4108IND Tetr family transcriptional regulator HV045_15570 ENOG4107MBR 17 kDa surface antigen HV045_15575 ENOG4105CEP NADH dehydrogenase HV045_15590 ENOG4108RUM thiamine kinase HV045_15595 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV045_15600 ENOG41090DQ Lipoprotein HV045_15605 ENOG4105K59 histidine triad (HIT) protein HV045_15610 ENOG4105CNM Receptor HV045_15620 ENOG4105UQX Mate efflux family protein HV045_15655 ENOG4105HVQ Regulatory factor of maltose metabolism HV045_15665 ENOG4105F2I Transposase HV045_15680 ENOG4107R11 Transcriptional regulator HV045_15700 ENOG4105CSH Transporter HV045_15705 ENOG4105FYV Amp nucleosidase HV045_15710 ENOG4105DC7 peptidase M24 HV045_15715 ENOG4105CI1 PTS System HV045_15720 ENOG4105F8V Hydrolase, tatD family HV045_15725 ENOG4107QRG dna polymerase iii HV045_15730 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HV045_15735 ENOG4105HHA aminodeoxychorismate lyase HV045_15740 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV045_15745 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV045_15750 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV045_15755 ENOG4105CHR reductase HV045_15760 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV045_15765 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HV045_15770 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HV045_15775 ENOG4105VGS 50s ribosomal protein l32 HV045_15780 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV045_15790 ENOG4105EI2 Pseudouridine synthase HV045_15795 ENOG4107QQB Ribonuclease E HV045_15800 ENOG4105DTJ flagellar hook-associated protein HV045_15805 ENOG4105E1Q flagellar hook-associated protein HV045_15810 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV045_15815 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) HV045_15825 ENOG4105CGA flagellar basal-body rod protein FlgG HV045_15830 ENOG4108KPB Flagellar basal-body rod protein FlgF HV045_15835 ENOG4105BZE flagellar hook protein, FlgE HV045_15840 ENOG4105W00 Flagellar hook capping protein HV045_15845 ENOG4108ZC9 flagellar basal-body rod protein flgc HV045_15850 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HV045_15855 ENOG4105CKS Flagella basal body P-ring formation protein flgA HV045_15860 ENOG4105M9M anti-sigma28 factor FlgM HV045_15865 ENOG4105QVD Flagella synthesis protein FlgN HV045_15870 ENOG4105CJR Integral membrane protein (MviN HV045_15875 ENOG4105EP9 oxidoreductase HV045_15885 ENOG4105D9U N-acetyltransferase HV045_15890 ENOG4105EV4 Multidrug resistance protein mdtH HV045_15895 ENOG4105F3T (LipO)protein HV045_15900 ENOG4105EKE dihydroorotase HV045_15905 ENOG4105MEA DNA damage-inducible protein i HV045_15910 ENOG4105PVA Biofilm formation regulatory protein BssS HV045_15915 ENOG4105F76 Sarcosine oxidase HV045_15920 ENOG4106974 biofilm formation HV045_15925 ENOG4105DS1 cytochrome b561 HV045_15930 ENOG4108YYC ycei family HV045_15940 ENOG4105D1S lipid A biosynthesis HV045_15945 ENOG4105C6X Major Facilitator HV045_15950 ENOG4108W47 Acidic protein msyB HV045_15955 ENOG4105NAC (LipO)protein HV045_15960 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HV045_15975 ENOG4107RZC phospholipase d HV045_15980 ENOG4108UVJ appr-1-p processing domain protein HV045_15990 ENOG4105F2I Transposase HV045_15995 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HV045_16000 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HV045_16005 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HV045_16010 ENOG41086KC Transcriptional regulator HV045_16015 ENOG4108XDW curli assembly protein CsgE HV045_16020 ENOG4108WYR Curli production assembly transport component, CsgF HV045_16025 ENOG4105P8Q Curli production assembly transport component CsgG HV045_16030 ENOG4108UQ5 membrane protein YcdZ HV045_16035 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV045_16040 ENOG4107SSZ Phosphatase HV045_16045 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HV045_16060 ENOG4105D5M phosphate starvation-inducible protein HV045_16070 ENOG4105DBE peroxidase HV045_16085 ENOG4105CK7 Sodium proline symporter HV045_16090 ENOG4105C26 Dehydrogenase HV045_16095 ENOG4105VTN Protein of unknown function (DUF1311) HV045_16100 ENOG4108R86 Transcriptional regulator HV045_16110 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV045_16115 ENOG4105CS1 NAD(P)H quinone oxidoreductase HV045_16120 ENOG4105XH3 HV045_16125 ENOG4105D6F Phosphatase HV045_16130 ENOG4108ZHR arsR family transcriptional regulator HV045_16140 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV045_16145 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HV045_16160 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HV045_16170 ENOG4105DVC DnaJ domain protein HV045_16195 ENOG4108QW8 Purine nucleoside phosphorylase deoD-type HV045_16215 ENOG4105EHG Permease protein HV045_16220 ENOG4105E0A ABC, transporter HV045_16235 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HV045_16250 ENOG4108J59 Extracellular solute-binding protein, family 5 HV045_16255 ENOG4108MN8 Membrane HV045_16295 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HV045_16300 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV045_16315 ENOG4105K4P CoA-binding domain protein HV045_16320 ENOG4108Q67 UPF0319 protein HV045_16325 ENOG4108Z5K methylglyoxal synthase HV045_16330 ENOG41088T4 Helicase IV HV045_16335 ENOG410901E Membrane HV045_16340 ENOG4105EM2 membrane HV045_16345 ENOG4108RZ1 DNA transformation protein HV045_16355 ENOG4105UYK outer membrane protein a HV045_16360 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HV045_16365 ENOG4105DAN ATP-dependent protease HV045_16375 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV045_16380 ENOG4108Q2G (LipO)protein HV045_16385 ENOG4105DY2 Paraquat-inducible protein b HV045_16390 ENOG4105F1S paraquat-inducible protein a HV045_16395 ENOG4105C5H ABC transporter HV045_16400 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HV045_16405 ENOG4105QVC MOSC domain-containing protein HV045_16410 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV045_16420 ENOG4108UZX fmn reductase HV045_16425 ENOG4105GVF (ABC) transporter HV045_16430 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HV045_16435 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV045_16445 ENOG4105CD8 aminopeptidase N HV045_16450 ENOG4107RH7 Nicotinate phosphoribosyltransferase HV045_16465 ENOG4105CGF Aromatic amino acid aminotransferase HV045_16470 ENOG4105C5X domain protein HV045_16475 ENOG4105EAQ (twin-arginine translocation) pathway signal HV045_16480 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV045_16485 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HV045_16490 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV045_16500 ENOG4106371 Methyltransferase HV045_16505 ENOG4107S90 membrAne HV045_16510 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV045_16515 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HV045_16525 ENOG4105T0Z Conserved Protein HV045_16530 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HV045_16535 ENOG4105BZ1 (ABC) transporter HV045_16540 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV045_16545 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HV045_16550 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV045_16555 ENOG4105CAT Cytidine monophosphate kinase HV045_16560 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HV045_16565 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HV045_16570 ENOG4107VMU Membrane HV045_16575 ENOG4105DDY UPF0142 protein ycaO HV045_16580 ENOG4105TMB Formate nitrite transporter HV045_16585 ENOG4105C6N Formate acetyltransferase HV045_16590 ENOG4105F1A Pyruvate formate-lyase HV045_16610 ENOG4108HHA Transketolase HV045_16620 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV045_16625 ENOG4108ISG Major Facilitator HV045_16630 ENOG4105CHJ isochorismatase hydrolase HV045_16635 ENOG4107KGK dmso reductase anchor subunit HV045_16640 ENOG4105QAX Iron-sulfur HV045_16645 ENOG4107QY8 reductase HV045_16650 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HV045_16655 ENOG4105D1H recombination factor protein RarA HV045_16665 ENOG4105CNU cell division protein FtsK HV045_16670 ENOG4105EW9 transcriptional regulator AsnC family HV045_16675 ENOG4105C3M thioredoxin reductase HV045_16680 ENOG4108JJ9 ABC, transporter HV045_16685 ENOG4108JJ8 (ABC) transporter HV045_16690 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HV045_16705 ENOG4105CC0 LysR family Transcriptional regulator HV045_16710 ENOG4105EUB pirin domain protein HV045_16715 ENOG4105CHJ isochorismatase hydrolase HV045_16730 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HV045_16735 ENOG4105RBQ inner membrane protein ybjO HV045_16740 ENOG4105D38 putrescine abc transporter HV045_16745 ENOG4105F38 ABC transporter, permease HV045_16750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV045_16755 ENOG4107RUE extracellular solute-binding protein family 1 HV045_16760 ENOG4108RMJ sensory transduction regulator HV045_16765 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HV045_16770 ENOG4108DBC nitroreductase HV045_16775 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HV045_16780 ENOG41090BQ Glutaredoxin HV045_16785 ENOG4105GWF inner membrane protein YbjM HV045_16790 ENOG4105D0C transport protein HV045_16795 ENOG4105DMW Dehydrogenase reductase HV045_16800 ENOG4108RFG Tetr family transcriptional regulator HV045_16805 ENOG4106UW1 Major Facilitator superfamily HV045_16810 ENOG4108HCJ Hydrolase HV045_16820 ENOG4107QF7 multi-drug HV045_16825 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV045_16830 ENOG4107FB0 transcriptional regulator DeoR family HV045_16835 ENOG4105DZ1 carboxypeptidase HV045_16840 ENOG4108TGY Glutathione S-transferase HV045_16845 ENOG4105D8V Glucose sorbosone dehydrogenase HV045_16850 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV045_16865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV045_16870 ENOG4105DEF Extracellular solute-binding protein, family 5 HV045_16875 ENOG4108JQ6 ABC transporter HV045_16880 ENOG4105D44 asparaginase HV045_16890 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV045_16895 ENOG4105D06 uba thif-type nad fad binding protein HV045_16900 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV045_16905 ENOG4105F1A Pyruvate formate-lyase HV045_16915 ENOG4108HCJ Hydrolase HV045_16920 ENOG41072TH Protein of unknown function (DUF1479) HV045_16925 ENOG4105C5H ABC transporter HV045_16930 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV045_16935 ENOG4105F4P )-transporter HV045_16940 ENOG4105KST dependent repressor HV045_16950 ENOG4108I6E Sulfatase HV045_16955 ENOG4108T1M outer membrane protein x HV045_16965 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HV045_16970 ENOG4107R0W ABC transporter HV045_16975 ENOG4105E5Q amino acid AbC transporter HV045_16980 ENOG4105CDA abc transporter atp-binding protein HV045_16985 ENOG4105D8X mechanosensitive ion channel HV045_16990 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) HV045_16995 ENOG4105ZY9 UPF0379 protein ybiM HV045_17000 ENOG4108IU3 tonb-dependent siderophore receptor HV045_17010 ENOG4105KSC Transcriptional regulator, TraR DksA family HV045_17015 ENOG4105VR4 UPF0379 protein ybiJ HV045_17020 ENOG4105DG4 malate L-lactate dehydrogenase HV045_17025 ENOG4108MTB glycosyl transferase family HV045_17030 ENOG4105DVT helicase HV045_17035 ENOG4105C1J atp-dependent rna helicase HV045_17040 ENOG4107MVR Transcriptional regulator HV045_17045 ENOG4105D0S secretion protein (HlyD HV045_17050 ENOG4105CJ1 ABC, transporter HV045_17055 ENOG4107QWP ABC-2 type transporter HV045_17060 ENOG4107QWP ABC-2 type transporter HV045_17065 ENOG4105I9U inner membrane protein ybhQ HV045_17070 ENOG4105X23 Endonuclease Exonuclease phosphatase HV045_17075 ENOG4105DZQ phospholipase D Transphosphatidylase HV045_17080 ENOG4107UXM Membrane HV045_17085 ENOG4105HFZ Membrane HV045_17090 ENOG4108ZAF Molybdopterin HV045_17095 ENOG4105M00 molybdopterin converting factor, subunit 1 HV045_17100 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HV045_17105 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV045_17115 ENOG4105CHW UPF0052 protein HV045_17120 ENOG4105DFD Na H antiporter HV045_17130 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HV045_17135 ENOG4108IV0 ABC, transporter HV045_17140 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV045_17145 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV045_17150 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV045_17160 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV045_17180 ENOG4108V1U phospholipid-binding protein HV045_17185 ENOG4105C84 Histidine ammonia-lyase HV045_17190 ENOG4105CGP Urocanate hydratase HV045_17200 ENOG41088SP formiminoglutamate hydrolase HV045_17210 ENOG4105NBR Pectinesterase HV045_17215 ENOG4105XB6 Toxin coregulated pilin HV045_17225 ENOG4105F9F transposase HV045_17235 ENOG4105GRU toxin co-regulated pilus biosynthesis outer membrane protein C HV045_17255 ENOG4107QHF type ii secretion system protein e HV045_17260 ENOG4108VEY type ii secretion system HV045_17265 ENOG4105F2I Transposase HV045_17280 ENOG4105E4C Lytic transglycosylase catalytic HV045_17295 ENOG4108K4B hydrolase HV045_17305 ENOG4105E0C molybdate abc transporter HV045_17310 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV045_17320 ENOG4105F4R Transcriptional regulator mode HV045_17325 ENOG4105DKW ABC transporter HV045_17330 ENOG4105CMR udp-glucose 4-epimerase HV045_17335 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV045_17340 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HV045_17345 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV045_17350 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HV045_17355 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV045_17360 ENOG4105JND homeobox protein HV045_17365 ENOG4105PGM cation diffusion facilitator family transporter HV045_17370 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV045_17405 ENOG4105UFD tol-pal system protein YbgF HV045_17410 ENOG4105KCK Peptidoglycan-associated lipoprotein HV045_17420 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV045_17430 ENOG4105E02 MotA TolQ exbB proton channel HV045_17435 ENOG4107YD3 Thioesterase HV045_17440 ENOG4105KJB cyd operon protein YbgE HV045_17450 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV045_17455 ENOG4105C4M (Ubiquinol oxidase) subunit I HV045_17460 ENOG4107WFU Glutamate mutase subunit sigma HV045_17470 ENOG4105DJI Methylaspartate mutase, E subunit HV045_17495 ENOG4105CSV Glutaminase HV045_17500 ENOG4107GFK fumarate HV045_17505 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV045_17510 ENOG4105ETT transcriptional Regulator, LysR family HV045_17515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HV045_17535 ENOG4105G63 Type III effector Hrp-dependent HV045_17545 ENOG4105MVE transcriptional regulator HV045_17550 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HV045_17575 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV045_17580 ENOG4105CMV Succinyl-CoA synthetase subunit beta HV045_17585 ENOG4105C7S Dehydrogenase HV045_17590 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV045_17595 ENOG4105E33 succinate dehydrogenase HV045_17600 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV045_17605 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV045_17610 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV045_17615 ENOG4105BZN citrate synthase HV045_17620 ENOG4108KK1 membrane protein AbrB duplication HV045_17630 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HV045_17645 ENOG4105E7W lamb ycsf family protein HV045_17650 ENOG4107R7A Allophanate hydrolase subunit 2 HV045_17655 ENOG4105P4J Allophanate hydrolase, subunit 1 HV045_17660 ENOG4107QNR UPF0135 protein HV045_17670 ENOG4105DNE Transposase HV045_17675 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV045_17680 ENOG4105XIQ Protein of unknown function (DUF2517) HV045_17705 ENOG4105C08 Histidine kinase HV045_17710 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV045_17720 ENOG4105CXN decarboxylase HV045_17725 ENOG4105D5Q Arginine ornithine antiporter HV045_17730 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV045_17735 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV045_17740 ENOG4105EV9 Alpha Beta Hydrolase HV045_17745 ENOG4105NNH LexA regulated protein HV045_17750 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV045_17760 ENOG41090R7 Ferric uptake HV045_17765 ENOG4106P55 Transcriptional regulator HV045_17770 ENOG4107EFR Flavocytochrome c HV045_17785 ENOG4105GX6 (LipO)protein HV045_17790 ENOG4105J5J Outer membrane porin HV045_17795 ENOG4105ETE Transcriptional regulator (LacI family HV045_17805 ENOG4105WEM extracellular solute-binding protein HV045_17815 ENOG4105CI1 PTS System HV045_17825 ENOG4105CE4 GlcNAc 6-P deacetylase HV045_17830 ENOG4105E2R ROK family HV045_17835 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV045_17840 ENOG4105CAQ asparagine synthetase HV045_17880 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV045_17885 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HV045_17890 ENOG4105C9A Phoh family HV045_17895 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HV045_17900 ENOG4108JU5 Magnesium and cobalt efflux protein HV045_17905 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV045_17910 ENOG4107RP9 extracellular solute-binding protein, family 3 HV045_17915 ENOG4105EAD ABC transporter HV045_17920 ENOG4105DRP amino acid AbC transporter HV045_17925 ENOG4105CDA abc transporter atp-binding protein HV045_17935 ENOG4105F2I Transposase HV045_17950 ENOG4107PAI alpha helical protein HV045_17955 ENOG4105C8T Leucyl-tRNA synthetase HV045_17965 ENOG4105DJF DNA polymerase III, delta' subunit HV045_17970 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HV045_17975 ENOG4107QZB decarboxylase HV045_17980 ENOG4108TGR phosphatase HV045_17985 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV045_17990 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HV045_17995 ENOG4105CJN penicillin-binding protein HV045_18000 ENOG4105CNI cell division protein FtsW HV045_18005 ENOG4105K6T rare lipoprotein A HV045_18010 ENOG4105DZ1 carboxypeptidase HV045_18015 ENOG4108Z43 UPF0250 protein HV045_18020 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HV045_18050 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV045_18055 ENOG4105CEE C4-dicarboxylate transporter HV045_18060 ENOG4106YYS transcriptional regulatory protein HV045_18065 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV045_18070 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV045_18080 ENOG4105CI0 Citrate lyase HV045_18085 ENOG4105CHY citrate lyase, alpha HV045_18090 ENOG4105YGP holo-ACP synthase CitX HV045_18095 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HV045_18100 ENOG4107QPK )-transporter HV045_18105 ENOG4105KTS ribonuclease HV045_18120 ENOG4105NXH GreA GreB family elongation factor HV045_18125 ENOG4108U51 Universal stress protein HV045_18135 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV045_18140 ENOG4108J2R molybdopterin oxidoreductase HV045_18150 ENOG4108JU3 Alkyl hydroperoxide reductase HV045_18155 ENOG4105D3R alkyl hydroperoxide reductase HV045_18160 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV045_18165 ENOG4105DQS Transcriptional regulator HV045_18170 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV045_18175 ENOG4105GTN ParB Domain Protein Nuclease HV045_18180 ENOG4105CHM Aminotransferase HV045_18185 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV045_18190 ENOG4105VCD cytoplasmic protein HV045_18195 ENOG4105D22 carbon starvation protein HV045_18200 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HV045_18205 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV045_18210 ENOG4105WQI isochorismatase HV045_18215 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV045_18220 ENOG4105E4F Isochorismate synthase HV045_18225 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV045_18230 ENOG4105E8G Major facilitator Superfamily HV045_18235 ENOG4105DQ5 transport system permease protein HV045_18240 ENOG4105TVJ transport system, permease HV045_18245 ENOG4105E0A ABC, transporter HV045_18250 ENOG4105C0W non-ribosomal peptide synthetase HV045_18255 ENOG41085A6 mbth domain-containing protein HV045_18260 ENOG4105E93 esterase HV045_18265 ENOG4107RNH Outer membrane receptor FepA HV045_18270 ENOG4108TSE Transferase HV045_18275 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV045_18285 ENOG4105C2J ABC transporter HV045_18290 ENOG4105CNN ABC, transporter HV045_18295 ENOG4105DKT Transcriptional regulator HV045_18300 ENOG4108HHA Transketolase HV045_18305 ENOG4108IUS Transketolase HV045_18315 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV045_18325 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HV045_18330 ENOG4105WQ6 Membrane HV045_18335 ENOG4105HFT AraC family transcriptional regulator HV045_18345 ENOG4105F2I Transposase HV045_18365 ENOG4106KCD HTH_LUXR HV045_18370 ENOG4106721 fimbriae Y protein HV045_18375 ENOG4108Q9V regulatoR HV045_18385 ENOG4108ZI2 Fimbrial protein HV045_18390 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HV045_18395 ENOG4105CW0 outer membrane usher protein HV045_18400 ENOG4108AF8 Chaperone HV045_18410 ENOG4108WDE Fimbrial protein HV045_18415 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HV045_18420 ENOG4105WQ3 Rna-binding protein HV045_18425 ENOG4105S2T inner membrane protein YbcI HV045_18435 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV045_18445 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV045_18450 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV045_18460 ENOG4108UMI ABC transporter, permease HV045_18470 ENOG4105D01 (LipO)protein HV045_18480 ENOG4105CV6 ABC transporter, permease HV045_18485 ENOG4108I0Y (ABC) transporter HV045_18490 ENOG4108UJV acyl-CoA thioesterase i HV045_18495 ENOG4105E1F short-chain dehydrogenase reductase HV045_18500 ENOG4107QR8 Thioredoxin HV045_18505 ENOG4105C4B ABC transporter, permease HV045_18510 ENOG41083J0 (ABC) transporter HV045_18515 ENOG4107QX8 SPFH domain, Band 7 family protein HV045_18520 ENOG4105G5H Membrane HV045_18535 ENOG4108Z6Z Transcriptional regulator HV045_18545 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV045_18550 ENOG4105D4P Coproporphyrinogen iii oxidase HV045_18560 ENOG4108C33 Resolvase HV045_18570 ENOG4105UZW Tail fiber assembly protein HV045_18585 ENOG41061A0 Mu-like prophage Flumu protein HV045_18590 ENOG4108T86 baseplate J family protein HV045_18620 ENOG41062PQ Mu-like prophage FluMu protein gp41 HV045_18630 ENOG4105TKZ Tail Sheath HV045_18660 ENOG4105EFV Major head subunit HV045_18680 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HV045_18685 ENOG4108Z6H mu-like prophage Flumu protein gp27 HV045_18765 ENOG4105IKI host-nuclease inhibitor protein HV045_18785 ENOG4108WTW DNA transposition protein HV045_18790 ENOG4106YXT transposase HV045_18815 ENOG4105EHG Permease protein HV045_18820 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HV045_18825 ENOG4105C59 p-type ATPase HV045_18830 ENOG4105MBR gumn family HV045_18835 ENOG4108Z66 YbaK ebsC protein HV045_18840 ENOG4105CGH 5'-nucleotidase HV045_18845 ENOG4105EU0 Major facilitator Superfamily HV045_18850 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV045_18855 ENOG4107RE1 Inosine-guanosine kinase HV045_18870 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HV045_18875 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HV045_18880 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HV045_18885 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HV045_18890 ENOG4107QMP dna polymerase iii subunits gamma and tau HV045_18895 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HV045_18900 ENOG4105WD1 Membrane HV045_18905 ENOG4108URS primosomal replication protein n'' HV045_18910 ENOG4106428 Protein of unknown function (DUF2496) HV045_18915 ENOG4105EGS Mechanosensitive ion channel HV045_18920 ENOG4107XI7 Tetr family transcriptional regulator HV045_18925 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV045_18930 ENOG4105BZS acriflavin resistance protein HV045_18935 ENOG4108UKR Biofilm formation regulator YbaJ HV045_18945 ENOG4108UW5 maltose o-acetyltransferase HV045_18950 ENOG4105GSJ Inner membrane protein ylaC HV045_18960 ENOG4105NRA 50s ribosomal protein l31 type b HV045_18965 ENOG41066DG (EAL) domain protein HV045_18970 ENOG4105KCV RNA signal recognition particle 4.5S RNA HV045_18975 ENOG4108VW9 Membrane HV045_18980 ENOG4107U9B transcriptional regulator HV045_19000 ENOG41080UX Methyltransferase HV045_19005 ENOG4108MNP Glycoprotein polysaccharide metabolism HV045_19010 ENOG4105C29 acyl-CoA thioesterase HV045_19015 ENOG4105BZU Histidine kinase HV045_19020 ENOG4108YZA Nitrogen regulatory protein pii HV045_19025 ENOG4105BZ1 (ABC) transporter HV045_19030 ENOG4105BZ1 (ABC) transporter HV045_19035 ENOG4108XM1 transcriptional regulator AsnC family HV045_19045 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HV045_19050 ENOG4108NFA extracellular solute-binding protein HV045_19055 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HV045_19060 ENOG4108TGP Thioesterase superfamily protein HV045_19065 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV045_19070 ENOG4105EIN peptidylprolyl cis-trans isomerase HV045_19075 ENOG4105K70 DNA-binding protein HV045_19080 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV045_19085 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HV045_19100 ENOG4105M85 Bola protein HV045_19105 ENOG4105IEY (LipO)protein HV045_19110 ENOG4105EYM Major Facilitator superfamily HV045_19115 ENOG4105E2S oxidase) subunit II HV045_19120 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV045_19125 ENOG4105CCU oxidase (Subunit III) HV045_19130 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV045_19155 ENOG4107RDB Major Facilitator HV045_19160 ENOG4108VPT UPF0234 protein HV045_19165 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV045_19170 ENOG4107S0N DJ-1 family HV045_19190 ENOG4105CTB Polyprenyl synthetase HV045_19200 ENOG4105CPC Aldo Keto reductase HV045_19205 ENOG4108ZAI phosphatidylglycerophosphatase a HV045_19210 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV045_19215 ENOG4107YIM Involved in the transcription termination process (By similarity) HV045_19220 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV045_19225 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV045_19235 ENOG4108KIC (LipO)protein HV045_19240 ENOG4105DRB nucleoside-specific channel-forming protein HV045_19255 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV045_19260 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV045_19265 ENOG4105VIE preprotein translocase, subunit YajC HV045_19270 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HV045_19275 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HV045_19285 ENOG4105D3R alkyl hydroperoxide reductase HV045_19300 ENOG4105EFZ amidohydrolase HV045_19310 ENOG4105CHJ isochorismatase hydrolase HV045_19315 ENOG4105EQ1 Transcriptional regulator HV045_19320 ENOG4107R28 alpha amylase, catalytic region HV045_19325 ENOG4105C85 amino acid HV045_19330 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV045_19335 ENOG4105BZU Histidine kinase HV045_19345 ENOG4107RH8 nuclease SbcCD subunit D HV045_19350 ENOG4105EYH Exonuclease HV045_19355 ENOG4105F27 Major Facilitator HV045_19360 ENOG4105DKQ ROK family HV045_19370 ENOG4105NBK UPF0345 protein HV045_19375 ENOG4105HBA AroM protein HV045_19380 ENOG4105SS3 HV045_19390 ENOG4108UPT UPF0178 protein HV045_19395 ENOG4105II7 pyrroline-5-carboxylate reductase HV045_19400 ENOG4105BZU Histidine kinase HV045_19405 ENOG4105VIF phosphate starvation-inducible protein HV045_19410 ENOG4105G6Z alkaline phosphatase HV045_19425 ENOG4105CPF Cell wall formation (By similarity) HV045_19430 ENOG4105UNH Membrane HV045_19435 ENOG4105FR5 inner membrane protein YaiY HV045_19440 ENOG4107QS8 (LipO)protein HV045_19445 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV045_19450 ENOG4107R6D beta-lactam binding protein AmpH HV045_19455 ENOG4108PNB DNA-binding transcriptional regulator HV045_19465 ENOG4105D52 delta-aminolevulinic acid dehydratase HV045_19470 ENOG4105E2B Taurine dioxygenase HV045_19475 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV045_19480 ENOG4108ETV ABC transporter HV045_19485 ENOG4106FTQ Taurine ABC transporter, periplasmic HV045_19490 ENOG4108KX4 response regulator HV045_19495 ENOG4105BZU Histidine kinase HV045_19500 ENOG4105CXY transporter HV045_19505 ENOG4105C4Y ABC transporter HV045_19510 ENOG4107RCV ABC transporter, permease HV045_19515 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV045_19520 ENOG4107QK5 Homocysteine s-methyltransferase HV045_19525 ENOG4108IQI permease HV045_19530 ENOG4108SC4 )-transporter HV045_19565 ENOG4108K2P TRANSCRIPTIONal HV045_19580 ENOG4105N0E Protein of unknown function (DUF2543) HV045_19600 ENOG4105CKT filamentous hemagglutinin HV045_19605 ENOG4105D5K Hemolysin activator protein HV045_19615 ENOG4105ETE Transcriptional regulator (LacI family HV045_19620 ENOG4105CNT hydrolase family 2 HV045_19635 ENOG4105DTA methyltransferase HV045_19640 ENOG4107R7Y intracellular protease Pfpi family HV045_19645 ENOG4105CUB amino acid HV045_19650 ENOG4105CFQ glutamine synthetase HV045_19655 ENOG4108Z86 Glutamine amidotransferase HV045_19660 ENOG4107VRI Transcriptional regulator HV045_19665 ENOG4105C26 Dehydrogenase HV045_19670 ENOG4105CJP fad dependent oxidoreductase HV045_19685 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HV045_19690 ENOG4108USZ hydrogenase HV045_19695 ENOG4108VXY Hydrogenase-1 operon protein HyaE HV045_19700 ENOG4105MVP hydrogenase-1 operon protein HyaF HV045_19705 ENOG4105C4M (Ubiquinol oxidase) subunit I HV045_19710 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV045_19720 ENOG41067CV Integrase HV045_19725 ENOG4105F2I Transposase HV045_19740 ENOG4108M0B Sucrose porin HV045_19765 ENOG4105EKQ RNA-directed DNA polymerase HV045_19775 ENOG4105F9F transposase HV045_19790 ENOG4105C8Q Methyl-accepting chemotaxis HV045_19795 ENOG4108BUD transposase HV045_19805 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_19830 ENOG4105D6F Phosphatase HV045_19840 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV045_19865 ENOG4108MXD gtp-binding protein HV045_19870 ENOG4106H6R UPF0380 protein HV045_19875 ENOG4108KZE transcriptional regulator HV045_19890 ENOG4106J9S Prophage HV045_19895 ENOG4106ZN7 UPF0401 protein YkfF HV045_19900 ENOG4106549 Antirestriction protein HV045_19905 ENOG4108XS9 dna repair protein HV045_19910 ENOG4105ZS6 Protein of unknown function (DUF987) HV045_19920 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HV045_19935 ENOG4108M8H domain protein HV045_19955 ENOG4105F9F transposase HV045_19965 ENOG4106PYX Receptor HV045_19985 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV045_19990 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HV045_19995 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HV045_20005 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HV045_20010 ENOG4105V1F Fermentation respiration switch protein HV045_20020 ENOG4105CIN aminoacyl-histidine dipeptidase HV045_20025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV045_20040 ENOG4107RD7 Flagellar Motor Protein, MotA HV045_20070 ENOG410804A Flagellar hook-associated 2 domain-containing protein HV045_20075 ENOG4105I03 Flagellin HV045_20095 ENOG4105DTJ flagellar hook-associated protein HV045_20100 ENOG4105E1Q flagellar hook-associated protein HV045_20105 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV045_20120 ENOG4105CGA flagellar basal-body rod protein FlgG HV045_20125 ENOG4108KPB Flagellar basal-body rod protein FlgF HV045_20140 ENOG4108ZC9 flagellar basal-body rod protein flgc HV045_20175 ENOG4105F2I Transposase HV045_20180 ENOG4105DD5 Flagellar motor switch protein HV045_20190 ENOG4105VS8 Flagellar biosynthetic protein fliq HV045_20195 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV045_20200 ENOG4105D00 flagellar biosynthetic protein flhB HV045_20210 ENOG4108YS0 lipoprotein YafL HV045_20215 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV045_20220 ENOG4105E7A Glutamine amidotransferase HV045_20230 ENOG4107QPN acyl-Coa dehydrogenase HV045_20235 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV045_20245 ENOG4105CMB EAL domain-containing protein HV045_20260 ENOG4108MDY Fimbrial HV045_20265 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HV045_20270 ENOG4108FZ9 Chaperone HV045_20275 ENOG4106PG1 outer membrane usher protein HV045_20285 ENOG4108TH4 Major fimbrial subunit HV045_20305 ENOG4107RZZ dna polymerase iii epsilon subunit HV045_20310 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV045_20315 ENOG4105D1A Methyltransferase HV045_20320 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HV045_20325 ENOG4105E9H Lytic Murein transglycosylase HV045_20330 ENOG4105F2W methyltransferase HV045_20340 ENOG4105F27 Major Facilitator HV045_20345 ENOG4105HEI LysR family (Transcriptional regulator HV045_20350 ENOG4105CV8 reductase HV045_20380 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV045_20385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV045_20390 ENOG4108UMI ABC transporter, permease HV045_20395 ENOG4105D01 (LipO)protein HV045_20400 ENOG4108R8X outer membrane lipoprotein HV045_20405 ENOG4108R96 Methyltransferase, YaeB family HV045_20410 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HV045_20415 ENOG4108UY0 (LipO)protein HV045_20420 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV045_20425 ENOG4108YZN class I peptide chain release factor HV045_20430 ENOG4108VWS Yaeq family HV045_20440 ENOG4105M1T rho-binding antiterminator HV045_20445 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV045_20450 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV045_20455 ENOG4105CXN decarboxylase HV045_20460 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HV045_20465 ENOG4105C0B DNA polymerase III (alpha subunit) HV045_20470 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HV045_20475 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV045_20490 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV045_20495 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV045_20500 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV045_20510 ENOG4105KNE Phosphatidate cytidylyltransferase HV045_20520 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV045_20525 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HV045_20530 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HV045_20540 ENOG4105CE9 30S ribosomal protein S2 HV045_20545 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV045_20550 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HV045_20555 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HV045_20565 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV045_20570 ENOG4105C0H protease HV045_20575 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HV045_20580 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HV045_20585 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV045_20590 ENOG4105EN6 Membrane HV045_20595 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HV045_20600 ENOG4105CMQ Chloride channel HV045_20610 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV045_20615 ENOG4105J76 Periplasmic binding protein HV045_20620 ENOG4105E0A ABC, transporter HV045_20625 ENOG4105E0K tonB-dependent siderophore receptor HV045_20630 ENOG4105BZ4 penicillin-binding protein HV045_20635 ENOG4105CQ7 ATP-dependent helicase HV045_20640 ENOG4107XID 2'-5' rna ligase HV045_20645 ENOG4105PW4 Sugar fermentation stimulation protein homolog HV045_20650 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters HV045_20655 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HV045_20660 ENOG4105DJ0 Poly(A) Polymerase HV045_20665 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV045_20685 ENOG4107BJW polysaccharide deacetylase HV045_20690 ENOG4108YTN IIa component HV045_20695 ENOG4105E3A (ABC) transporter HV045_20700 ENOG4105DA5 (ABC) transporter HV045_20705 ENOG41077A9 carbonic anhydrase HV045_20710 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV045_20715 ENOG4105DZG Dehydrogenase HV045_20725 ENOG4105E3B Multicopper oxidase HV045_20730 ENOG4108ZRK uncharacterized protein yacC HV045_20745 ENOG4107QIJ Aconitate hydratase 2 HV045_20750 ENOG4108NST exported protein HV045_20765 ENOG4107QN2 dihydrolipoyl dehydrogenase HV045_20770 ENOG4107QSN dihydrolipoamide acetyltransferase HV045_20775 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV045_20785 ENOG4105C85 amino acid HV045_20790 ENOG4105CT4 transporter HV045_20795 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HV045_20800 ENOG4106A72 regulatory protein AmpE HV045_20810 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV045_20815 ENOG4108ZUW Major pilin subunit HV045_20820 ENOG4107QHF type ii secretion system protein e HV045_20825 ENOG4105D7Q type ii secretion system HV045_20830 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV045_20835 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV045_20840 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) HV045_20845 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HV045_20850 ENOG4105M6F mutator MutT protein HV045_20860 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HV045_20870 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV045_20875 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV045_20880 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV045_20885 ENOG4105CPF Cell wall formation (By similarity) HV045_20895 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HV045_20900 ENOG4105CNI cell division protein FtsW HV045_20905 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HV045_20910 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HV045_20915 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV045_20920 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV045_20925 ENOG4105CJN penicillin-binding protein HV045_20930 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV045_20940 ENOG4108V6E Cell division protein mraZ HV045_20945 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV045_20950 ENOG4108ZP8 Acetolactate synthase small subunit HV045_20955 ENOG4105C7K acetolactate synthase HV045_20960 ENOG41064T2 transcriptional regulator, lysR family HV045_20980 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV045_20985 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HV045_20990 ENOG4105S8Q sugar efflux transporter HV045_21010 ENOG4106SMU thiamine transporter membrane protein HV045_21020 ENOG4108KF1 Membrane HV045_21040 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV045_21050 ENOG4105CQ2 DNA polymerase HV045_21055 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HV045_21060 ENOG4105D3G Pseudouridine synthase HV045_21070 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HV045_21080 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HV045_21085 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HV045_21090 ENOG4105NWN ApaG protein HV045_21095 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HV045_21105 ENOG4105CKD glutathione-regulated potassium-efflux system protein HV045_21115 ENOG4105M5B (LipO)protein HV045_21120 ENOG4105C54 Major Facilitator superfamily HV045_21125 ENOG4105WQV ferredoxin-like protein HV045_21130 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV045_21175 ENOG4108XNW Transcriptional activatory protein CaiF HV045_21180 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV045_21185 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV045_21190 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HV045_21195 ENOG4107P2S Transcriptional regulator HV045_21210 ENOG4105DAS pts system HV045_21215 ENOG4105ETZ PTS System HV045_21220 ENOG4105F3R pts system mannose fructose sorbose family iid HV045_21230 ENOG4108Y83 glucose-6-phosphate isomerase HV045_21235 ENOG4105DU0 nucleoside hydrolase HV045_21240 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HV045_21245 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV045_21255 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HV045_21260 ENOG4105DTN riboflavin biosynthesis protein ribF HV045_21285 ENOG41063Z6 transcriptional regulator, lysR family HV045_21300 ENOG4105CFG Acts as a chaperone (By similarity) HV045_21305 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV045_21315 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV045_21320 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV045_21325 ENOG4105BZG amino acid carrier protein HV045_21330 ENOG4105D1Q UPF0246 protein HV045_21335 ENOG4105D98 threonine synthase HV045_21345 ENOG4105CFH Aspartokinase HV045_21355 ENOG4106FVC RNA methyltransferase HV045_21360 ENOG410759A HV045_21365 ENOG41065U4 response regulator HV045_21370 ENOG4105CT7 inner membrane cred family protein HV045_21375 ENOG4105EB3 Histidine kinase HV045_21380 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV045_21385 ENOG4108RH0 Crea protein HV045_21390 ENOG4105UEI Transcriptional Regulator AraC Family HV045_21395 ENOG4105CVJ phosphoglycerate mutase HV045_21400 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV045_21405 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HV045_21410 ENOG4107SC1 transglycosylase HV045_21415 ENOG4105C5H ABC transporter HV045_21420 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV045_21425 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV045_21430 ENOG4105EAC phosphoserine phosphatase HV045_21435 ENOG41062Z9 Membrane HV045_21465 ENOG4105G0K glycine radical enzyme YjjI family HV045_21470 ENOG41076CZ activating enzyme HV045_21475 ENOG4105EYA deoxyribonuclease HV045_21480 ENOG4108NRW Phospholipase, patatin family HV045_21490 ENOG4105K3G Periplasmic Protein HV045_21495 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HV045_21500 ENOG4105PAD Hydrolase HV045_21505 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV045_21510 ENOG4108WPU DNA polymerase III subunit psi HV045_21535 ENOG4105YBH Protein of unknown function (DUF1435) HV045_21540 ENOG4105BZU Histidine kinase HV045_21545 ENOG4108819 ferric iron reductase HV045_21550 ENOG4105CK1 PTS System HV045_21555 ENOG4108UIN ybak prolyl-trna synthetase associated region HV045_21560 ENOG4108T94 DNA-binding transcriptional activator BglJ HV045_21565 ENOG4108N8T regulatoR HV045_21570 ENOG4105DWK Membrane HV045_21575 ENOG4107XM3 UPF0442 protein HV045_21580 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HV045_21585 ENOG4106CVF DNA replication protein HV045_21590 ENOG4105RI1 glycoprotein receptor HV045_21605 ENOG4105CPQ Dehydrogenase HV045_21610 ENOG410617M Transcriptional regulator HV045_21615 ENOG4108I5G Major Facilitator superfamily HV045_21620 ENOG4105XYF acetyltransferase HV045_21625 ENOG4105C8Q Methyl-accepting chemotaxis HV045_21630 ENOG4105D22 carbon starvation protein HV045_21635 ENOG4105VCD cytoplasmic protein HV045_21640 ENOG4105CKI cobalamin synthesis protein HV045_21670 ENOG4106H3A restriction HV045_21705 ENOG4105EFX secretion protein, HlyD family HV045_21715 ENOG4106DIZ Domain of unknown function (DUF1127) HV045_21720 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV045_21725 ENOG4105DNE Transposase HV045_21725 ENOG4105DNE Transposase HV045_21730 ENOG4106AXJ AraC family transcriptional regulator HV045_21740 ENOG41083G8 Multidrug resistance protein MdtM HV045_21745 ENOG4105C28 cystathionine HV045_21750 ENOG4105CK2 sodium dicarboxylate symporter HV045_21755 ENOG410642W LysR family Transcriptional regulator HV045_21760 ENOG4106BRA Membrane HV045_21765 ENOG4105CBP Major Facilitator HV045_21775 ENOG4105FCK Membrane HV045_21785 ENOG4105C6F GntR Family Transcriptional Regulator HV045_21790 ENOG4105DEI Mannitol dehydrogenase HV045_21800 ENOG4107EFN gluconate transport system permease 3 HV045_21805 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HV045_21810 ENOG4107QR9 Iron-sulfur cluster binding protein HV045_21815 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV045_21895 ENOG4105ZTC transcriptional activator, Ogr delta HV045_21905 ENOG4105ESI atpase involved in dna repair HV045_21920 ENOG4105DQ4 alcohol dehydrogenase HV045_21925 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV045_21930 ENOG4105CPQ Dehydrogenase HV045_21935 ENOG4105CHR reductase HV045_21940 ENOG4105C6Z Gluconate HV045_21945 ENOG4105K2J Transcriptional regulator HV045_21950 ENOG4105D7A ATP-binding protein HV045_21955 ENOG4108K5H permease YjgP YjgQ family protein HV045_21960 ENOG4108M8S permease YjgP YjgQ family protein HV045_21965 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HV045_21970 ENOG4105MYG DNA polymerase iii, chi subunit HV045_21975 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV045_21980 ENOG4108M3P Membrane HV045_21985 ENOG4108MJ3 acetyltransferase HV045_21995 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HV045_22000 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV045_22010 ENOG4105XEP YhcH YjgK YiaL family protein HV045_22035 ENOG4105CEU Arginine dihydrolase HV045_22040 ENOG4105C5B carbamate kinase HV045_22045 ENOG4105DBV ornithine carbamoyltransferase HV045_22050 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV045_22055 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HV045_22065 ENOG4107C93 pyrBI operon leader peptide HV045_22075 ENOG4105CXT aspartate transcarbamylase HV045_22080 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) HV045_22085 ENOG4105KME endoribonuclease L-psp HV045_22090 ENOG4107EF2 surface-exposed virulence protein HV045_22100 ENOG4105D4X repressor HV045_22105 ENOG4105C5Y PTS System HV045_22110 ENOG4105CG3 alpha amylase, catalytic region HV045_22115 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV045_22120 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV045_22130 ENOG4105CS6 Rhs element vgr protein HV045_22135 ENOG4105K4U addiction module toxin, RelE StbE family HV045_22150 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV045_22215 ENOG4105EMD TRANSCRIPTIONal HV045_22230 ENOG41069H0 dihydroorotase EC 3.5.2.3 HV045_22260 ENOG4108XVM Cytochrome b(562) HV045_22265 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV045_22270 ENOG4105N42 UPF0307 protein HV045_22275 ENOG4105CK1 PTS System HV045_22280 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HV045_22285 ENOG4105F8D glycoside hydrolase family 4 HV045_22290 ENOG4105C2X Arabinose 5-phosphate isomerase HV045_22295 ENOG4105DFU Cell wall formation (By similarity) HV045_22300 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 HV045_22305 ENOG4105C8Q Methyl-accepting chemotaxis HV045_22310 ENOG41062B0 ABC transporter, permease HV045_22315 ENOG4107R9N ABC transporter HV045_22320 ENOG4105C2J ABC transporter HV045_22325 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV045_22330 ENOG4105F0N pyrophosphate phospho-hydrolase HV045_22335 ENOG4108NS2 receptor HV045_22340 ENOG4105D05 Receptor HV045_22345 ENOG4108ZHD aig2 family HV045_22350 ENOG4105MA0 exported protein HV045_22355 ENOG4105CFU surface antigen HV045_22365 ENOG4105C37 (CBS) domain HV045_22370 ENOG41061GZ Protein of unknown function (DUF1107) HV045_22375 ENOG4108UUE Transcriptional regulator HV045_22380 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV045_22390 ENOG4108C33 Resolvase HV045_22400 ENOG4105PTU response to oxidative stress HV045_22405 ENOG4108US3 tail fiber assembly HV045_22515 ENOG4108QUU Morphogenesis Protein HV045_22525 ENOG4105CF2 Mu-like prophage FluMu protein GP28 HV045_22645 ENOG4105ZIA Phage protein gp16 HV045_22660 ENOG4105KVH Transcriptional regulator HV045_22665 ENOG4105ECR NmrA family HV045_22675 ENOG4105DXC membrane HV045_22680 ENOG4105C8Q Methyl-accepting chemotaxis HV045_22685 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) HV045_22690 ENOG4105C85 amino acid HV045_22695 ENOG4108V1T peptidylprolyl cis-trans isomerase HV045_22700 ENOG4105FHY Opacity-associated protein A HV045_22710 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HV045_22715 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV045_22720 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HV045_22730 ENOG4105EJ9 Membrane HV045_22735 ENOG4105KIT UPF0379 protein yjfY HV045_22750 ENOG4105H6Q decarboxylase HV045_22775 ENOG4105DW5 Transcriptional regulator HV045_22780 ENOG4108MXZ Esterase HV045_22785 ENOG4105WSB biofilm stress and motility protein A HV045_22790 ENOG4105S17 UPF0379 protein yjfN HV045_22795 ENOG4105CSU acyl-Coa dehydrogenase HV045_22800 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV045_22805 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV045_22815 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HV045_22825 ENOG4105EPW hflc protein HV045_22830 ENOG4107QJR hflk protein HV045_22835 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV045_22840 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HV045_22850 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HV045_22855 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV045_22860 ENOG4105K8N protein family UPF0079, ATPase HV045_22865 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV045_22870 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV045_22900 ENOG4105DJ4 phosphatidylserine decarboxylase HV045_22905 ENOG4105EGS Mechanosensitive ion channel HV045_22910 ENOG4106CG8 Inner membrane protein YjeO HV045_22920 ENOG4107SC7 Inner membrane transporter yjeM HV045_22925 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HV045_22930 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV045_22935 ENOG4105E33 succinate dehydrogenase HV045_22945 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HV045_22990 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV045_22995 ENOG4105MTB Uncharacterized protein YjeJ HV045_23000 ENOG4108ZVF (LipO)protein HV045_23005 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HV045_23015 ENOG4105DVH amino acid HV045_23020 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV045_23025 ENOG4108IJ0 Aspartate ammonia-lyase HV045_23030 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV045_23040 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HV045_23045 ENOG4108SIC Transcriptional regulator HV045_23060 ENOG4105F2I Transposase HV045_23080 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV045_23125 ENOG4108MXD gtp-binding protein HV045_23195 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV045_23200 ENOG4108MRH transcriptional regulatory protein HV045_23210 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV045_23215 ENOG4107GFK fumarate HV045_23220 ENOG4108R5S membrane HV045_23225 ENOG4105W3H MtN3 and saliva related transmembrane protein HV045_23230 ENOG4105CT4 transporter HV045_23235 ENOG4105F8D glycoside hydrolase family 4 HV045_23240 ENOG4108K2B transcriptional regulator HV045_23245 ENOG4105CXN decarboxylase HV045_23250 ENOG4106ZGR Transcriptional regulator HV045_23255 ENOG4105D5Q Arginine ornithine antiporter HV045_23260 ENOG4105DIJ Phosphoethanolamine transferase HV045_23265 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV045_23270 ENOG4105ECM Sensor protein basS pmrB HV045_23280 ENOG4105CSH Transporter HV045_23285 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HV045_23290 ENOG4108YIV HV045_23295 ENOG4108F5E vimentin HV045_23300 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV045_23305 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV045_23310 ENOG4105D5T phosphonate abc transporter HV045_23315 ENOG4105EHI Phosphonate ABC transporter, periplasmic HV045_23325 ENOG4107RJJ Transcriptional regulator HV045_23330 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HV045_23335 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HV045_23340 ENOG4105EKV Phosphonate metabolism protein HV045_23345 ENOG4105FT8 Phosphonate metabolism HV045_23350 ENOG4105ENV phosphonate C-P lyase system protein PhnK HV045_23355 ENOG4105HRV phosphonate c-p lyase system protein phnl HV045_23360 ENOG4105FD8 phosphonate metabolism protein PhnM HV045_23365 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HV045_23370 ENOG410849A acetyltransferase, (GNAT) family HV045_23375 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HV045_23395 ENOG4105CNN ABC, transporter HV045_23400 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV045_23435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV045_23440 ENOG41062QD Membrane HV045_23445 ENOG4107QN1 sodium solute HV045_23450 ENOG41067MG lrgb family HV045_23460 ENOG4105CMU LysR family (Transcriptional regulator HV045_23465 ENOG4105EEQ Na H antiporter HV045_23470 ENOG4105C7N Xanthine uracil vitamin C permease HV045_23475 ENOG4108Z4X TRANSCRIPTIONal HV045_23480 ENOG4108W3Q Transcriptional regulator HV045_23490 ENOG4105F2I Transposase HV045_23495 ENOG4105PMV Membrane HV045_23500 ENOG4108UUM single-stranded DNA-binding protein HV045_23505 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV045_23510 ENOG4105MSB protein, conserved in bacteria HV045_23515 ENOG4105F0S class B acid phosphatase HV045_23520 ENOG4105CGF Aromatic amino acid aminotransferase HV045_23530 ENOG4105CDU Replicative dna helicase HV045_23535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV045_23540 ENOG4105P4Z Phage shock protein G HV045_23545 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV045_23555 ENOG4105MYN Zinc uptake regulation protein HV045_23560 ENOG4105VDW Csbd family HV045_23565 ENOG4107R73 Mate efflux family protein HV045_23575 ENOG41080IJ Diacylglycerol kinase HV045_23580 ENOG4105E55 glycerol-3-phosphate acyltransferase HV045_23585 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HV045_23590 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HV045_23595 ENOG4107W52 maltose operon periplasmic protein HV045_23605 ENOG4108IJ9 (ABC) transporter HV045_23610 ENOG4107FKK extracellular solute-binding protein family 1 HV045_23615 ENOG4105D56 permease protein HV045_23620 ENOG4105EG2 ABC transporter, permease HV045_23625 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HV045_23630 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV045_23635 ENOG4105E3R (LipO)protein HV045_23640 ENOG4108Q9C Periplasmic Protein HV045_23645 ENOG4108MDC (LipO)protein HV045_23660 ENOG4105CFH Aspartokinase HV045_23665 ENOG4105C09 Bile acid HV045_23670 ENOG4108ZR5 Conserved Protein HV045_23675 ENOG4105FE9 pseudouridine synthase HV045_23680 ENOG4105ECQ AraC Family Transcriptional Regulator HV045_23695 ENOG4105EAM Na Pi-cotransporter HV045_23700 ENOG4105C3R Methionine synthase HV045_23705 ENOG41069M3 Transcriptional regulator HV045_23710 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HV045_23715 ENOG4108I9X Isocitrate lyase HV045_23720 ENOG4107QP3 malate synthase g HV045_23725 ENOG4105CVG Homoserine O-transsuccinylase HV045_23755 ENOG4105C12 Phosphoribosylglycinamide synthetase HV045_23760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV045_23765 ENOG4105BZU Histidine kinase HV045_23775 ENOG4108T8B Protein of unknown function (DUF1481) HV045_23780 ENOG4105K70 DNA-binding protein HV045_23785 ENOG4105R2J Conserved Protein HV045_23795 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HV045_23805 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HV045_23820 ENOG4105D06 uba thif-type nad fad binding protein HV045_23825 ENOG4105WHD thiamine biosynthesis protein ThiS HV045_23835 ENOG4105D41 biosynthesis protein thiH HV045_23840 ENOG4105VEQ Cold shock protein HV045_23850 ENOG4105VCP PTS System HV045_23855 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV045_23860 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HV045_23865 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HV045_23870 ENOG4108VZM 50s ribosomal protein L10 HV045_23875 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HV045_23880 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HV045_23885 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV045_23890 ENOG4105PM1 preprotein translocase subunit SecE HV045_23925 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV045_23930 ENOG4105D4A Cell wall formation (By similarity) HV045_23975 ENOG4108Y73 Membrane HV045_23980 ENOG4105EJ2 Transcriptional regulator HV045_23990 ENOG4105C5Q Transcriptional regulator HV045_23995 ENOG4108NNZ chitinase HV045_24000 ENOG4105CH7 arginosuccinase HV045_24005 ENOG4105CAS nag kinase HV045_24015 ENOG4105CWC Acetylornithine deacetylase HV045_24020 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HV045_24025 ENOG4105DIJ Phosphoethanolamine transferase HV045_24030 ENOG4106R3P AraC family transcriptional regulator HV045_24035 ENOG4108XCZ PTS System HV045_24040 ENOG4108AHH pyruvate formate lyase II activase HV045_24050 ENOG4108YRF PTS System HV045_24055 ENOG4105DM4 PTS System HV045_24060 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV045_24070 ENOG4105DCT glycerol dehydrogenase HV045_24075 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) HV045_24080 ENOG4105SYT Methylenetetrahydrofolate reductase HV045_24085 ENOG4105CN8 Transcriptional regulator HV045_24095 ENOG4105CGH 5'-nucleotidase HV045_24105 ENOG4105CFH Aspartokinase HV045_24110 ENOG4105C28 cystathionine HV045_24115 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HV045_24120 ENOG4105CT4 transporter HV045_24125 ENOG4108QGT oligogalacturonate-specific porin HV045_24135 ENOG4105C25 Primosomal protein n' HV045_24140 ENOG4105ETE Transcriptional regulator (LacI family HV045_24145 ENOG41063M6 Cell Division Protein HV045_24155 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HV045_24160 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV045_24175 ENOG4105DFP Integrase HV045_24195 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) HV045_24200 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV045_24205 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HV045_24210 ENOG4105CBT Fructose-1,6-bisphosphatase HV045_24215 ENOG4105DP0 ferredoxin-NADP reductase HV045_24220 ENOG4108VTS Membrane HV045_24225 ENOG4105EBK exported protein HV045_24240 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HV045_24245 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV045_24250 ENOG4105CTQ phosphohexokinase HV045_24255 ENOG41076HS cation diffusion facilitator family transporter HV045_24260 ENOG4105FMW periplasmic HV045_24265 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV045_24270 ENOG4105E0F Histidine kinase HV045_24280 ENOG4105F2I Transposase HV045_24290 ENOG4108KHF Resistance protein HV045_24295 ENOG4108K85 Transcriptional regulator HV045_24300 ENOG4108RPX mosc domain containing protein HV045_24305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV045_24315 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV045_24320 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HV045_24325 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HV045_24330 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) HV045_24340 ENOG4105DKG l-rhamnose isomerase HV045_24350 ENOG4105C0A alcohol dehydrogenase HV045_24365 ENOG4105F2I Transposase HV045_24375 ENOG4108UMN azlc family HV045_24385 ENOG41064BA PTS system, fructose-specific, IIA component HV045_24390 ENOG4105DM4 PTS System HV045_24395 ENOG4105CN9 Peptidase m42 family protein HV045_24400 ENOG4106C3V frv operon regulatory protein HV045_24420 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV045_24425 ENOG4108MG3 formate dehydrogenase HV045_24430 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HV045_24440 ENOG41068KX affects formate dehydrogenase-N HV045_24450 ENOG4105X54 addiction module antidote protein HV045_24460 ENOG4105SUU thioesterase domain HV045_24465 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HV045_24470 ENOG4107S2Z UPF0761 membrane protein HV045_24490 ENOG4105E98 transcriptional regulator DeoR family HV045_24495 ENOG4108MGF sugar kinase HV045_24500 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV045_24505 ENOG4105D2M Aldolase HV045_24510 ENOG4107QKS N-acylglucosamine 2-epimerase HV045_24515 ENOG4107WI4 Aldose-1-epimerase HV045_24520 ENOG4105CJQ hydrolase, family 31 HV045_24530 ENOG4105CT4 transporter HV045_24535 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HV045_24540 ENOG4105CI3 gtp-binding protein typa HV045_24545 ENOG4105C5F glutamine synthetase HV045_24550 ENOG4105CUX Signal transduction histidine kinase HV045_24555 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV045_24560 ENOG4106FIY HV045_24565 ENOG4105D4P Coproporphyrinogen iii oxidase HV045_24585 ENOG4105C2M dna polymerase I HV045_24590 ENOG4106HNH Acyl-transferase HV045_24595 ENOG4108Z33 Thiol disulfide Interchange Protein HV045_24605 ENOG4105PC1 Conserved Protein HV045_24610 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV045_24615 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV045_24645 ENOG4108RR8 protoporphyrinogen oxidase HV045_24650 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV045_24655 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV045_24665 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV045_24675 ENOG4105ETE Transcriptional regulator (LacI family HV045_24680 ENOG4105DKQ ROK family HV045_24685 ENOG4107QK7 reductase HV045_24690 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV045_24695 ENOG4105MDZ Transcriptional activator rfaH HV045_24700 ENOG4105F8V Hydrolase, tatD family HV045_24705 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV045_24710 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV045_24715 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV045_24725 ENOG4105JC1 sterol-binding domain protein HV045_24735 ENOG4105CGY Dna recombination protein HV045_24740 ENOG4107SXA Phosphorylase HV045_24745 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV045_24750 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HV045_24755 ENOG4105DZ2 Transcriptional regulator HV045_24760 ENOG4105EMK carboxylate amino acid amine transporter HV045_24765 ENOG4105DQF Hydrolase HV045_24770 ENOG4108EUD Lysophospholipase HV045_24775 ENOG410829K Lysine exporter protein (Lyse ygga) HV045_24780 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV045_24785 ENOG4105C9U ATP-dependent DNA helicase RecQ HV045_24790 ENOG4105HDD phospholipase HV045_24795 ENOG4108VUY thioesterase Superfamily protein HV045_24800 ENOG4105FR1 rard protein HV045_24805 ENOG4107QUT magnesium and cobalt transport protein CorA HV045_24810 ENOG4105C4R Atp-dependent dna helicase HV045_24815 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV045_24820 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV045_24825 ENOG4105CT0 Protein of unknown function, DUF484 HV045_24835 ENOG4105S7Z (LipO)protein HV045_24845 ENOG4107T0K Adenylate cyclase HV045_24855 ENOG41076E6 Uroporphyrinogen-III Synthase HV045_24860 ENOG4105ECF c-methyltransferase HV045_24865 ENOG410601J HemY protein HV045_24890 ENOG4105C85 amino acid HV045_24895 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HV045_24900 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HV045_24905 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HV045_24910 ENOG4105EGZ biosynthesis protein HV045_24915 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV045_24920 ENOG4108WJ1 acetyltransferase HV045_24925 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HV045_24930 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV045_24935 ENOG4108IJ1 Dehydrogenase HV045_24940 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV045_24945 ENOG4105SFE lipopolysaccharide biosynthesis protein HV045_24950 ENOG4105ESV Glycosyl transferase, family 4 HV045_24955 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV045_24975 ENOG4105C9X ppx gppa phosphatase HV045_24980 ENOG4105C4R Atp-dependent dna helicase HV045_24985 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV045_24995 ENOG4105EMY transcriptional regulator HV045_25000 ENOG4105RKW reductase (By HV045_25005 ENOG4105C7B Threonine dehydratase HV045_25015 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV045_25020 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV045_25035 ENOG4105C0P Mg chelatase subunit ChlI HV045_25040 ENOG4108WFC UPF0438 protein yifE HV045_25080 ENOG4107EJG GntR family transcriptional regulator HV045_25085 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV045_25090 ENOG4105ETE Transcriptional regulator (LacI family HV045_25095 ENOG4108RVA ribokinase HV045_25100 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV045_25105 ENOG4105CNN ABC, transporter HV045_25115 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HV045_25130 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HV045_25140 ENOG4108VVK transcriptional Regulator, AsnC HV045_25145 ENOG4105QTB Flavodoxin HV045_25155 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HV045_25160 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV045_25165 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) HV045_25175 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV045_25180 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HV045_25185 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HV045_25190 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HV045_25195 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HV045_25200 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HV045_25205 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HV045_25210 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV045_25215 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV045_25220 ENOG4105C8U phosphate abc transporter HV045_25225 ENOG4105E2Z phosphate ABC transporter (Permease HV045_25230 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV045_25240 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV045_25245 ENOG4105C7N Xanthine uracil vitamin C permease HV045_25250 ENOG4108YYH Nadph-dependent fmn reductase HV045_25255 ENOG4105E8Q phosphopantetheinyl transferase HV045_25260 ENOG4105G2Y Transcriptional regulator HV045_25265 ENOG4105CNH Multidrug resistance protein MdtL HV045_25270 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HV045_25285 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) HV045_25290 ENOG4105VG0 50S ribosomal protein l34 HV045_25380 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HV045_25390 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HV045_25395 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV045_25400 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV045_25440 ENOG4105D13 transposase HV045_25445 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_25460 ENOG4105F2I Transposase HV045_25465 ENOG4108BUD transposase HV045_25470 ENOG4108UEC Ferritin-like protein HV045_25475 ENOG4108BUD transposase HV045_25495 ENOG4108X6F Transcriptional regulator MerD HV045_25510 ENOG4105XIV Mercuric transport protein, periplasmic component HV045_25535 ENOG4105BZS acriflavin resistance protein HV045_25540 ENOG4105ENT Efflux transporter rnd family, mfp subunit HV045_25545 ENOG4108U51 Universal stress protein HV045_25600 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_25605 ENOG4108C33 Resolvase HV045_25645 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_25650 ENOG4105CYM Glutathione S-transferase HV045_25655 ENOG4107RFB Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HV045_25670 ENOG4105F04 LysR family Transcriptional regulator HV045_25680 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HV045_25695 ENOG4105E66 phosphoriboisomerase A HV045_25715 ENOG41067TZ transcriptional regulator, MarR family HV045_25720 ENOG4105DUM transcriptional regulator, lysR family HV045_25750 ENOG4108BUD transposase HV045_25775 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_25790 ENOG4105W1Y Transcriptional regulator HV045_25800 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HV045_25805 ENOG4108XM1 transcriptional regulator AsnC family HV045_25810 ENOG4105DWP Membrane HV045_25820 ENOG4105EQR Transposase IS116 IS110 IS902 HV045_25830 ENOG4105KT5 UmuD protein HV045_25835 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV045_25850 ENOG4105HVQ Regulatory factor of maltose metabolism HV045_25995 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV045_26000 ENOG4105DFE Dna adenine methylase HV045_26010 ENOG4105DH7 May be involved in recombination (By similarity) HV045_26065 ENOG4108WYP Transcriptional regulator HV045_26165 ENOG4105F9F transposase HV045_26205 ENOG4105CEM UPF0597 protein HV045_26220 ENOG4105DHJ ABC, transporter HV045_26235 ENOG4108BUD transposase HV045_26265 ENOG4105C3F Signal peptidase i HV045_26310 ENOG4105C4R Atp-dependent dna helicase HV045_26585 ENOG4107712 HV045_26645 ENOG4105DVT helicase HV045_26840 ENOG4105C2U cobyrinic Acid a,c-diamide synthase HV045_26890 ENOG4105E5H Transposase HV045_26895 ENOG4108YXQ IS66 Orf2 family protein HV045_26920 ENOG4105E5H Transposase HV045_26925 ENOG4108YXQ IS66 Orf2 family protein HV045_27030 ENOG4106JVB Replication Protein HV045_27100 ENOG4107R8N Glycosyl transferase, family 2