locus-tag	class	description
HV045_00010	COG0592	DNA-directed DNA polymerase activity
HV045_00025	COG0561	phosphatase activity
HV045_00035	COG0823	Involved in the tonB-independent uptake of proteins
HV045_00040	COG5645	(Lipo)protein
HV045_00065	COG2188	Transcriptional regulator
HV045_00080	COG2207	Transcriptional regulator
HV045_00085	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV045_00090	COG3119	arylsulfatase activity
HV045_00095	COG2149	membrane
HV045_00105	COG0641	radical SAM
HV045_00115	COG2610	gluconate transmembrane transporter activity
HV045_00120	COG0583	DNA-binding transcription factor activity
HV045_00130	COG2814	Major facilitator Superfamily
HV045_00150	COG0028	Belongs to the TPP enzyme family
HV045_00155	COG0440	acetolactate synthase activity
HV045_00160	COG1349	DNA-binding transcription factor activity
HV045_00170	COG0738	Major facilitator superfamily
HV045_00180	COG2197	response regulator
HV045_00200	COG2826	transposase and inactivated derivatives, IS30 family
HV045_00265	COG1136	(ABC) transporter
HV045_00275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HV045_00290	COG0582	viral genome integration into host DNA
HV045_00300	COG2211	Major facilitator Superfamily
HV045_00305	COG1501	Belongs to the glycosyl hydrolase 31 family
HV045_00310	COG3711	transcriptional antiterminator
HV045_00315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_00315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_00315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_00320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_00325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_00325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_00335	COG0191	fructose-bisphosphate aldolase activity
HV045_00345	COG2982	Protein involved in outer membrane biogenesis
HV045_00350	COG2233	PERMEase
HV045_00355	COG0786	glutamate:sodium symporter activity
HV045_00360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV045_00365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV045_00370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV045_00390	COG2860	membrane
HV045_00395	COG1561	YicC-like family, N-terminal region
HV045_00420	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV045_00435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV045_00450	COG1519	Transferase
HV045_00455	COG0859	PFAM glycosyl transferase family 9
HV045_00460	COG0438	transferase activity, transferring glycosyl groups
HV045_00465	COG0515	serine threonine protein kinase
HV045_00490	COG0859	PFAM glycosyl transferase family 9
HV045_00495	COG0859	PFAM glycosyl transferase family 9
HV045_00515	COG0156	8-amino-7-oxononanoate synthase activity
HV045_00540	COG1216	Glycosyl transferase, family 2
HV045_00545	COG2861	carbohydrate metabolic process
HV045_00550	COG4942	peptidase
HV045_00560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV045_00565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV045_00585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV045_00590	COG2271	Major facilitator Superfamily
HV045_00600	COG2186	Transcriptional regulator
HV045_00620	COG3722	fumarate hydratase activity
HV045_00630	COG2213	PTS system mannitol-specific
HV045_00630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_00640	COG1566	PFAM secretion protein HlyD family protein
HV045_00645	COG0625	glutathione transferase activity
HV045_00655	COG3276	selenocysteine insertion sequence binding
HV045_00660	COG1454	alcohol dehydrogenase
HV045_00665	COG1012	belongs to the aldehyde dehydrogenase family
HV045_00675	COG1566	PFAM secretion protein HlyD family protein
HV045_00680	COG0583	DNA-binding transcription factor activity
HV045_00685	COG3713	MltA-interacting MipA family protein
HV045_00695	COG0235	Class ii aldolase
HV045_00700	COG3623	hexulose-6-phosphate isomerase
HV045_00705	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HV045_00710	COG1070	Carbohydrate kinase
HV045_00715	COG2271	Major facilitator Superfamily
HV045_00725	COG2731	YhcH YjgK YiaL family protein
HV045_00735	COG1414	Transcriptional regulator
HV045_00740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV045_00745	COG3977	Valine--pyruvate aminotransferase
HV045_00750	COG0366	Alpha amylase catalytic
HV045_00755	COG2992	FlgJ-related protein
HV045_00760	COG2207	Transcriptional regulator
HV045_00760	COG1609	Transcriptional regulator
HV045_00765	COG4214	carbohydrate transport
HV045_00775	COG4213	ABC transporter substrate-binding protein
HV045_00785	COG1070	Carbohydrate kinase
HV045_00790	COG4682	membrane
HV045_00795	COG4682	membrane
HV045_00800	COG3274	enterobacterial common antigen metabolic process
HV045_00825	COG1278	Cold shock
HV045_00830	COG2944	sequence-specific DNA binding
HV045_00845	COG2814	Major facilitator Superfamily
HV045_00850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_00860	COG1609	Transcriptional regulator
HV045_00865	COG2885	chlorophyll binding
HV045_00870	COG0243	molybdopterin cofactor binding
HV045_00880	COG2818	Glycosylase
HV045_00885	COG5571	outer membrane autotransporter
HV045_00890	COG2223	nitrite transmembrane transporter activity
HV045_00915	COG0747	negative chemotaxis
HV045_00920	COG0601	transmembrane transport
HV045_00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV045_00930	COG0444	Belongs to the ABC transporter superfamily
HV045_00935	COG4608	Belongs to the ABC transporter superfamily
HV045_00940	COG2204	response regulator
HV045_00945	COG0814	amino acid
HV045_00950	COG0626	cystathionine gamma-synthase activity
HV045_00960	COG2199	diguanylate cyclase activity
HV045_00960	COG2200	EAL domain
HV045_00975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_00980	COG2200	EAL domain
HV045_00985	COG2982	Protein involved in outer membrane biogenesis
HV045_00990	COG0477	Major facilitator Superfamily
HV045_00995	COG1295	ribonuclease BN
HV045_01000	COG0583	DNA-binding transcription factor activity
HV045_01005	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_01010	COG2197	response regulator
HV045_01020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV045_01035	COG1858	cytochrome C peroxidase
HV045_01040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV045_01045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV045_01050	COG0339	signal peptide processing
HV045_01065	COG3039	Transposase
HV045_01070	COG0246	Mannitol dehydrogenase
HV045_01075	COG1349	DNA-binding transcription factor activity
HV045_01085	COG2213	PTS system mannitol-specific
HV045_01085	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_01100	COG1959	2 iron, 2 sulfur cluster binding
HV045_01110	COG0589	response to stress
HV045_01120	COG0306	phosphate transporter
HV045_01125	COG2081	HI0933 family
HV045_01145	COG5642	Protein of unknown function (DUF2384)
HV045_01160	COG3621	Patatin-like phospholipase
HV045_01205	COG2239	Acts as a magnesium transporter
HV045_01210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV045_01215	COG1129	ABC transporter
HV045_01215	COG0842	Transport permease protein
HV045_01220	COG0842	Transport permease protein
HV045_01235	COG3479	Phenolic acid decarboxylase
HV045_01240	COG2091	lysine biosynthetic process via aminoadipic acid
HV045_01245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV045_01250	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_01260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV045_01285	COG1216	Glycosyl transferase, family 2
HV045_01305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HV045_01335	COG0628	permease
HV045_01340	COG0477	Major facilitator Superfamily
HV045_01350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV045_01365	COG3714	YhhN family
HV045_01375	COG3776	membrane
HV045_01380	COG0742	ribosomal rna small subunit methyltransferase
HV045_01385	COG0552	protein localization to endoplasmic reticulum
HV045_01390	COG2884	Cell division ATP-binding protein ftsE
HV045_01395	COG2177	Part of the ABC transporter FtsEX involved in
HV045_01415	COG0683	leucine binding
HV045_01425	COG4177	L-phenylalanine transmembrane transporter activity
HV045_01430	COG0411	ABC transporter
HV045_01435	COG0410	ABC transporter
HV045_01465	COG0584	glycerophosphoryl diester phosphodiesterase
HV045_01475	COG0405	Gamma-glutamyltransferase
HV045_01485	COG1247	-acetyltransferase
HV045_01490	COG0673	inositol 2-dehydrogenase activity
HV045_01495	COG1741	Belongs to the pirin family
HV045_01500	COG1609	Transcriptional regulator
HV045_01505	COG3265	gluconokinase activity
HV045_01510	COG2610	gluconate transmembrane transporter activity
HV045_01520	COG2095	MarC family integral membrane protein
HV045_01525	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV045_01550	COG0058	SHG alpha-glucan phosphorylase activity
HV045_01555	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV045_01570	COG1349	DNA-binding transcription factor activity
HV045_01580	COG0058	SHG alpha-glucan phosphorylase activity
HV045_01585	COG1640	4-alpha-glucanotransferase
HV045_01590	COG2610	gluconate transmembrane transporter activity
HV045_01600	COG1040	competence protein
HV045_01610	COG5464	transposase or invertase
HV045_01625	COG1918	ferrous iron import across plasma membrane
HV045_01630	COG2183	response to ionizing radiation
HV045_01635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV045_01640	COG0745	RESPONSE REGULATOR receiver
HV045_01655	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV045_01665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV045_01670	COG1011	Hydrolase
HV045_01680	COG0494	nUDIX hydrolase
HV045_01685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV045_01690	COG4972	Pilus assembly protein
HV045_01710	COG4796	Type ii and iii secretion system protein
HV045_01725	COG3266	domain, Protein
HV045_01730	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV045_01735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV045_01745	COG0180	Tryptophanyl-tRNA synthetase
HV045_01765	COG2146	nitrite reductase [NAD(P)H] activity
HV045_01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV045_01795	COG0512	Glutamine amidotransferase of anthranilate synthase
HV045_01800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV045_01815	COG1765	OsmC-like protein
HV045_01820	COG3954	Phosphoribulokinase
HV045_01830	COG0429	hydrolase of the alpha beta-hydrolase fold
HV045_01835	COG0488	(ABC) transporter
HV045_01850	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV045_01855	COG1047	Peptidyl-prolyl cis-trans
HV045_01865	COG0545	Peptidyl-prolyl cis-trans isomerase
HV045_01870	COG2964	Protein conserved in bacteria
HV045_01930	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HV045_01935	COG3156	type II secretion system protein K
HV045_01940	COG4795	General secretion pathway protein
HV045_01945	COG2165	general secretion pathway protein
HV045_01950	COG2165	general secretion pathway protein
HV045_01955	COG2165	general secretion pathway protein
HV045_01960	COG1459	type II secretion system
HV045_01965	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV045_01970	COG1450	Type ii and iii secretion system protein
HV045_01990	COG0051	transcription antitermination factor activity, RNA binding
HV045_02000	COG0088	Forms part of the polypeptide exit tunnel
HV045_02015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV045_02090	COG0200	Binds to the 23S rRNA
HV045_02095	COG0201	protein transport
HV045_02110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV045_02135	COG0789	Transcriptional regulator
HV045_02140	COG3036	rescue of stalled ribosome
HV045_02150	COG0569	domain protein
HV045_02170	COG0758	DNA mediated transformation
HV045_02180	COG0551	DNA topoisomerase type I activity
HV045_02200	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV045_02240	COG1126	abc transporter atp-binding protein
HV045_02245	COG0765	amino acid transport
HV045_02250	COG4597	amino acid ABC transporter
HV045_02255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV045_02265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV045_02270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV045_02280	COG1309	transcriptional regulator
HV045_02290	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV045_02345	COG4145	pantothenate transmembrane transporter activity
HV045_02350	COG3924	membrane
HV045_02355	COG0439	Biotin carboxylase
HV045_02360	COG0511	ligase activity, forming carbon-carbon bonds
HV045_02375	COG0604	alcohol dehydrogenase
HV045_02380	COG2200	EAL domain
HV045_02380	COG2199	diguanylate cyclase activity
HV045_02385	COG1077	Cell shape determining protein MreB Mrl
HV045_02390	COG1792	Involved in formation and maintenance of cell shape
HV045_02395	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV045_02405	COG1530	ribonuclease E activity
HV045_02410	COG3164	Protein of unknown function
HV045_02415	COG0312	modulator of DNA gyrase
HV045_02420	COG0583	DNA-binding transcription factor activity
HV045_02440	COG2732	(Barnase) inhibitor
HV045_02460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV045_02465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV045_02470	COG3105	Protein conserved in bacteria
HV045_02475	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV045_02490	COG0625	glutathione transferase activity
HV045_02495	COG2969	positive regulation of protein catabolic process
HV045_02500	COG3069	C4-dicarboxylate transmembrane transporter activity
HV045_02530	COG2731	YhcH YjgK YiaL family protein
HV045_02535	COG0402	S-adenosylhomocysteine deaminase activity
HV045_02540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV045_02545	COG0493	'glutamate synthase
HV045_02550	COG0069	glutamate synthase activity
HV045_02550	COG0067	glutamate synthase
HV045_02550	COG0070	glutamate synthase
HV045_02555	COG1242	4 iron, 4 sulfur cluster binding
HV045_02560	COG0784	Response regulator, receiver
HV045_02560	COG2198	Histidine kinase
HV045_02560	COG5002	protein histidine kinase activity
HV045_02565	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV045_02575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_02590	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV045_02600	COG1137	ATPase activity
HV045_02605	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV045_02610	COG3117	lipopolysaccharide transmembrane transporter activity
HV045_02615	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV045_02620	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV045_02620	COG0517	IMP dehydrogenase activity
HV045_02625	COG0530	calcium, potassium:sodium antiporter activity
HV045_02630	COG1127	ABC transporter
HV045_02635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV045_02640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV045_02645	COG2854	intermembrane phospholipid transfer
HV045_02650	COG3113	response to antibiotic
HV045_02655	COG5007	Belongs to the BolA IbaG family
HV045_02665	COG3423	Transcriptional regulator
HV045_02670	COG0142	geranyltranstransferase activity
HV045_02675	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV045_02680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV045_02685	COG0697	spore germination
HV045_02695	COG2027	D-alanyl-D-alanine carboxypeptidase
HV045_02705	COG1534	Rna-binding protein
HV045_02715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV045_02720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV045_02730	COG3069	C4-dicarboxylate transmembrane transporter activity
HV045_02735	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV045_02740	COG0583	DNA-binding transcription factor activity
HV045_02745	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV045_02770	COG0195	Participates in both transcription termination and antitermination
HV045_02780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV045_02810	COG0513	Belongs to the DEAD box helicase family
HV045_02815	COG0814	amino acid
HV045_02820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV045_02825	COG0826	peptidase U32
HV045_02830	COG0826	peptidase U32
HV045_02835	COG3154	lipid carrier protein
HV045_02840	COG3153	acetyltransferase
HV045_02855	COG0702	epimerase
HV045_02860	COG2823	Periplasmic or secreted lipoprotein
HV045_02875	COG3107	peptidoglycan biosynthetic process
HV045_02880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV045_02895	COG1063	alcohol dehydrogenase
HV045_02900	COG3775	system Galactitol-specific IIC component
HV045_02905	COG3414	Phosphotransferase system galactitol-specific IIB component
HV045_02910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_02925	COG2721	sulfolactate sulfo-lyase activity
HV045_02930	COG2271	Major facilitator Superfamily
HV045_02940	COG2084	Dehydrogenase
HV045_02945	COG1929	Belongs to the glycerate kinase type-1 family
HV045_02965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV045_02980	COG2963	transposase activity
HV045_02985	COG2826	transposase and inactivated derivatives, IS30 family
HV045_02995	COG3344	reverse transcriptase
HV045_03005	COG0583	DNA-binding transcription factor activity
HV045_03025	COG1882	Formate acetyltransferase
HV045_03030	COG0251	oxidation-reduction process
HV045_03035	COG1760	l-serine dehydratase
HV045_03040	COG0814	amino acid
HV045_03055	COG1741	Belongs to the pirin family
HV045_03060	COG0583	DNA-binding transcription factor activity
HV045_03065	COG3152	Membrane
HV045_03070	COG0435	Glutathione S-transferase
HV045_03075	COG2259	Doxx family
HV045_03085	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV045_03090	COG4575	ribosome binding
HV045_03095	COG1422	Protein of unknown function (DUF1090)
HV045_03105	COG0586	Pfam SNARE associated Golgi protein
HV045_03110	COG2186	Transcriptional regulator
HV045_03115	COG2271	Major facilitator Superfamily
HV045_03125	COG2721	sulfolactate sulfo-lyase activity
HV045_03145	COG0673	inositol 2-dehydrogenase activity
HV045_03150	COG1451	nucleotide metabolic process
HV045_03160	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV045_03160	COG1902	pentaerythritol trinitrate reductase activity
HV045_03175	COG1609	Transcriptional regulator
HV045_03185	COG1175	transmembrane transport
HV045_03190	COG0395	ABC-type sugar transport system, permease component
HV045_03195	COG0366	Alpha amylase catalytic
HV045_03200	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HV045_03215	COG3250	beta-galactosidase activity
HV045_03220	COG1609	Transcriptional regulator
HV045_03225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV045_03235	COG0840	transmembrane signaling receptor activity
HV045_03240	COG1695	Transcriptional regulator
HV045_03245	COG2375	cellular response to nickel ion
HV045_03255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV045_03320	COG0582	viral genome integration into host DNA
HV045_03360	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV045_03405	COG4695	Portal protein
HV045_03580	COG4983	Phage plasmid primase, P4 family domain protein
HV045_03600	COG3039	Transposase
HV045_03605	COG3596	GTP binding
HV045_03615	COG2378	regulation of single-species biofilm formation
HV045_03620	COG3468	outer membrane autotransporter barrel domain protein
HV045_03630	COG2003	Belongs to the UPF0758 family
HV045_03680	COG0358	DNA primase activity
HV045_03685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV045_03690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV045_03695	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV045_03705	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV045_03735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_03740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_03755	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV045_03770	COG4991	sh3 domain protein
HV045_03775	COG3025	triphosphatase activity
HV045_03840	COG3384	dioxygenase
HV045_03845	COG0754	glutathionylspermidine amidase activity
HV045_03855	COG1538	Outer membrane efflux protein
HV045_03860	COG0494	nUDIX hydrolase
HV045_03865	COG3151	Protein conserved in bacteria
HV045_03870	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV045_03875	COG3150	esterase
HV045_03880	COG0187	DNA topoisomerase II activity
HV045_03885	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV045_03890	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV045_03905	COG3111	PFAM Bacterial OB fold (BOF) protein
HV045_03925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV045_03940	COG0656	L-ascorbic acid biosynthetic process
HV045_03945	COG1979	alcohol dehydrogenase
HV045_03950	COG2207	Transcriptional regulator
HV045_03955	COG0586	Pfam SNARE associated Golgi protein
HV045_03960	COG0626	cystathionine gamma-synthase activity
HV045_03970	COG0848	biopolymer transport protein
HV045_03990	COG0667	Aldo Keto reductase
HV045_04000	COG0840	transmembrane signaling receptor activity
HV045_04010	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV045_04015	COG0437	4 iron, 4 sulfur cluster binding
HV045_04020	COG5557	Pfam Polysulphide reductase, NrfD
HV045_04025	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV045_04030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV045_04035	COG1773	rubredoxin
HV045_04045	COG0298	carbon dioxide binding
HV045_04050	COG0625	glutathione transferase activity
HV045_04055	COG0243	molybdopterin cofactor binding
HV045_04060	COG0754	glutathionylspermidine amidase activity
HV045_04085	COG2885	chlorophyll binding
HV045_04125	COG3039	Transposase
HV045_04185	COG3039	Transposase
HV045_04200	COG0412	Dienelactone hydrolase
HV045_04205	COG0840	transmembrane signaling receptor activity
HV045_04240	COG0582	viral genome integration into host DNA
HV045_04260	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV045_04265	COG0640	Transcriptional regulator
HV045_04270	COG0783	Belongs to the Dps family
HV045_04285	COG1342	Belongs to the UPF0251 family
HV045_04300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV045_04315	COG1136	(ABC) transporter
HV045_04330	COG1309	transcriptional regulator
HV045_04350	COG3039	Transposase
HV045_04355	COG1528	Iron-storage protein
HV045_04420	COG0210	DNA helicase
HV045_04430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HV045_04440	COG1811	Na channel or pump
HV045_04445	COG1982	Orn Lys Arg decarboxylase major
HV045_04450	COG2211	Major facilitator Superfamily
HV045_04465	COG1194	a g-specific adenine glycosylase
HV045_04475	COG3171	Protein conserved in bacteria
HV045_04485	COG0252	asparaginase activity
HV045_04495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV045_04510	COG0762	integral membrane protein
HV045_04515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV045_04535	COG2805	Type II/IV secretion system protein
HV045_04550	COG0189	ligase activity
HV045_04555	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV045_04560	COG2356	endonuclease I
HV045_04565	COG3091	SprT-like family
HV045_04570	COG2814	Major facilitator Superfamily
HV045_04590	COG1166	arginine decarboxylase activity
HV045_04600	COG0501	Belongs to the peptidase M48B family
HV045_04605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV045_04615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_04620	COG2213	PTS system mannitol-specific
HV045_04625	COG1063	alcohol dehydrogenase
HV045_04630	COG1494	fructose-1,6-bisphosphatase
HV045_04640	COG1072	(Pantothenic acid kinase))
HV045_04655	COG0191	fructose-bisphosphate aldolase activity
HV045_04660	COG0549	Belongs to the carbamate kinase family
HV045_04665	COG2271	Major facilitator Superfamily
HV045_04670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV045_04675	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV045_04685	COG0583	DNA-binding transcription factor activity
HV045_04690	COG0668	transmembrane transport
HV045_04700	COG1279	arginine transmembrane transporter activity
HV045_04705	COG2968	Membrane
HV045_04710	COG0583	DNA-binding transcription factor activity
HV045_04715	COG0427	acetyl-CoA hydrolase
HV045_04720	COG1024	Enoyl-CoA hydratase
HV045_04725	COG1703	isobutyryl-CoA mutase activity
HV045_04730	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV045_04730	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV045_04745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV045_04750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV045_04770	COG0006	proline dipeptidase activity
HV045_04775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV045_04780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV045_04800	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_04805	COG2723	6-phospho-beta-galactosidase activity
HV045_04810	COG1737	Transcriptional regulator
HV045_04820	COG1272	protein, Hemolysin III
HV045_04830	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV045_04855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV045_04875	COG4942	peptidase
HV045_04885	COG0582	viral genome integration into host DNA
HV045_04920	COG0583	DNA-binding transcription factor activity
HV045_04930	COG0765	amino acid transport
HV045_04940	COG4598	ABC transporter
HV045_04955	COG4372	Transposase
HV045_05015	COG3539	Fimbrial protein
HV045_05070	COG3311	Transcriptional regulator
HV045_05080	COG4983	Phage plasmid primase, P4 family domain protein
HV045_05105	COG2003	Belongs to the UPF0758 family
HV045_05130	COG3039	Transposase
HV045_05140	COG4783	chaperone-mediated protein folding
HV045_05140	COG1560	Kdo2-lipid A biosynthetic process
HV045_05155	COG3039	Transposase
HV045_05165	COG1682	transport, permease protein
HV045_05170	COG1596	polysaccharide export
HV045_05175	COG0438	transferase activity, transferring glycosyl groups
HV045_05180	COG3039	Transposase
HV045_05190	COG1649	PFAM Uncharacterised BCR, COG1649
HV045_05190	COG0726	polysaccharide deacetylase
HV045_05195	COG1215	transferase activity, transferring glycosyl groups
HV045_05205	COG3592	Divergent 4Fe-4S mono-cluster
HV045_05210	COG2388	GCN5-related N-acetyl-transferase
HV045_05215	COG0583	DNA-binding transcription factor activity
HV045_05220	COG0666	response to abiotic stimulus
HV045_05230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV045_05235	COG1304	FMN binding
HV045_05245	COG0549	Belongs to the carbamate kinase family
HV045_05250	COG0402	S-adenosylhomocysteine deaminase activity
HV045_05265	COG0814	amino acid
HV045_05280	COG0183	Belongs to the thiolase family
HV045_05290	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_05300	COG1794	racemase activity, acting on amino acids and derivatives
HV045_05305	COG0583	DNA-binding transcription factor activity
HV045_05315	COG1609	Transcriptional regulator
HV045_05335	COG0667	Aldo Keto reductase
HV045_05345	COG0861	Integral membrane protein TerC family
HV045_05375	COG2165	general secretion pathway protein
HV045_05380	COG4795	General secretion pathway protein
HV045_05390	COG4967	type IV pilus modification protein PilV
HV045_05395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV045_05405	COG1074	ATP-dependent DNA helicase activity
HV045_05410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV045_05415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV045_05415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV045_05420	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV045_05440	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV045_05445	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV045_05450	COG2166	iron-sulfur cluster assembly
HV045_05455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV045_05465	COG0583	DNA-binding transcription factor activity
HV045_05470	COG2363	Small membrane protein
HV045_05480	COG1349	DNA-binding transcription factor activity
HV045_05490	COG1070	Carbohydrate kinase
HV045_05500	COG1129	ABC transporter
HV045_05505	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_05525	COG0235	Class ii aldolase
HV045_05530	COG1454	alcohol dehydrogenase
HV045_05535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HV045_05540	COG1760	l-serine dehydratase
HV045_05545	COG0814	amino acid
HV045_05550	COG1611	Belongs to the LOG family
HV045_05565	COG3098	single-species biofilm formation
HV045_05570	COG0564	pseudouridine synthase activity
HV045_05575	COG0716	FMN binding
HV045_05580	COG2271	Major facilitator Superfamily
HV045_05585	COG4948	Mandelate Racemase Muconate Lactonizing
HV045_05590	COG4948	Mandelate Racemase Muconate Lactonizing
HV045_05595	COG1929	Belongs to the glycerate kinase type-1 family
HV045_05600	COG2205	protein histidine kinase activity
HV045_05600	COG3437	response regulator, receiver
HV045_05600	COG4999	Histidine kinase
HV045_05600	COG3850	Histidine kinase
HV045_05610	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV045_05615	COG3956	TIGRFAM MazG family protein
HV045_05630	COG1737	Transcriptional regulator
HV045_05635	COG2190	(PTS) system
HV045_05635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_05635	COG1263	PTS System
HV045_05640	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HV045_05645	COG0602	queuosine metabolic process
HV045_05650	COG1070	Carbohydrate kinase
HV045_05655	COG2223	nitrite transmembrane transporter activity
HV045_05660	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_05665	COG0277	FAD linked oxidase domain protein
HV045_05670	COG0477	Major facilitator Superfamily
HV045_05675	COG2086	electron transfer activity
HV045_05680	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV045_05685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HV045_05690	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV045_05695	COG0644	oxidoreductase
HV045_05700	COG0720	synthase
HV045_05720	COG1203	CRISPR-associated helicase, Cas3
HV045_05735	COG1857	crispr-associated protein
HV045_05750	COG1518	maintenance of DNA repeat elements
HV045_05755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV045_05760	COG2234	aminopeptidase activity
HV045_05815	COG4942	peptidase
HV045_05815	COG1388	LysM domain
HV045_05855	COG2200	EAL domain
HV045_05860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV045_05865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV045_05870	COG1121	(ABC) transporter
HV045_05890	COG0309	Hydrogenase expression formation protein (HypE)
HV045_05895	COG0409	Hydrogenase expression formation protein
HV045_05900	COG0298	carbon dioxide binding
HV045_05905	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV045_05920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV045_05925	COG0651	ATP synthesis coupled electron transport
HV045_05930	COG0650	Formate hydrogenlyase subunit 4
HV045_05935	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV045_05935	COG3261	NADH dehydrogenase
HV045_05940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV045_05945	COG3260	NADH ubiquinone oxidoreductase 20
HV045_05955	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV045_05970	COG2723	6-phospho-beta-galactosidase activity
HV045_05975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_05975	COG1263	PTS System
HV045_05980	COG1609	Transcriptional regulator
HV045_05985	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV045_05990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV045_06010	COG0517	IMP dehydrogenase activity
HV045_06010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV045_06015	COG1349	DNA-binding transcription factor activity
HV045_06020	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_06025	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_06035	COG3732	PTS system glucitol sorbitol-specific
HV045_06040	COG3730	PTS system glucitol sorbitol-specific
HV045_06045	COG2951	lytic endotransglycosylase activity
HV045_06050	COG1546	Belongs to the CinA family
HV045_06070	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV045_06095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV045_06100	COG1238	metal cluster binding
HV045_06115	COG2814	Major facilitator Superfamily
HV045_06120	COG1566	PFAM secretion protein HlyD family protein
HV045_06125	COG1846	Transcriptional regulator
HV045_06135	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV045_06140	COG2814	Major facilitator Superfamily
HV045_06150	COG4176	ABC-type proline glycine betaine transport system permease component
HV045_06180	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV045_06210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV045_06215	COG0640	Transcriptional regulator
HV045_06220	COG0401	homolog of Blt101
HV045_06225	COG1652	LysM domain
HV045_06230	COG1802	Transcriptional regulator
HV045_06235	COG1113	amino acid transport
HV045_06240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV045_06245	COG1012	belongs to the aldehyde dehydrogenase family
HV045_06250	COG0579	oxidoreductase
HV045_06265	COG3039	Transposase
HV045_06320	COG0438	transferase activity, transferring glycosyl groups
HV045_06325	COG0438	transferase activity, transferring glycosyl groups
HV045_06325	COG0297	glycogen (starch) synthase activity
HV045_06355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV045_06370	COG0582	viral genome integration into host DNA
HV045_06380	COG2826	transposase and inactivated derivatives, IS30 family
HV045_06390	COG2826	transposase and inactivated derivatives, IS30 family
HV045_06470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HV045_06480	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HV045_06490	COG0582	viral genome integration into host DNA
HV045_06500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV045_06525	COG2867	negative regulation of translational initiation
HV045_06540	COG0497	DNA recombination
HV045_06555	COG4536	flavin adenine dinucleotide binding
HV045_06560	COG4137	Cytochrome C assembly protein
HV045_06565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV045_06590	COG2885	chlorophyll binding
HV045_06595	COG2199	diguanylate cyclase activity
HV045_06610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV045_06615	COG1605	Chorismate mutase
HV045_06615	COG0287	Prephenate dehydrogenase
HV045_06620	COG1605	Chorismate mutase
HV045_06620	COG0077	Prephenate dehydratase
HV045_06630	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV045_06635	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV045_06650	COG0542	response to heat
HV045_06680	COG0477	Major facilitator Superfamily
HV045_06685	COG5544	Lipoprotein
HV045_06690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV045_06705	COG3118	belongs to the thioredoxin family
HV045_06710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV045_06725	COG0513	Belongs to the DEAD box helicase family
HV045_06735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV045_06745	COG1595	DNA-templated transcription, initiation
HV045_06755	COG3026	antisigma factor binding
HV045_06760	COG3086	response to oxidative stress
HV045_06770	COG0681	Belongs to the peptidase S26 family
HV045_06790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV045_06800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV045_06880	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV045_06885	COG4197	protein conserved in bacteria, prophage-related
HV045_06935	COG3179	chitinase
HV045_07075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV045_07085	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV045_07090	COG1737	Transcriptional regulator
HV045_07095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV045_07100	COG1263	PTS System
HV045_07100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_07105	COG0560	Phosphoserine phosphatase
HV045_07125	COG2205	protein histidine kinase activity
HV045_07130	COG3170	Tfp pilus assembly protein FimV
HV045_07135	COG2204	response regulator
HV045_07140	COG0347	Belongs to the P(II) protein family
HV045_07145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV045_07145	COG1017	nitric oxide dioxygenase activity
HV045_07155	COG1940	carbohydrate kinase activity
HV045_07160	COG0457	Tetratricopeptide repeat
HV045_07165	COG1879	ABC-type sugar transport system periplasmic component
HV045_07170	COG1129	ABC transporter
HV045_07175	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_07180	COG1063	alcohol dehydrogenase
HV045_07185	COG2017	converts alpha-aldose to the beta-anomer
HV045_07210	COG4638	Rieske (2fe-2S)
HV045_07215	COG0583	DNA-binding transcription factor activity
HV045_07220	COG3539	Fimbrial protein
HV045_07225	COG3188	usher protein
HV045_07230	COG3121	Chaperone
HV045_07235	COG3539	Fimbrial protein
HV045_07240	COG2814	Major facilitator Superfamily
HV045_07245	COG3711	transcriptional antiterminator
HV045_07250	COG0517	IMP dehydrogenase activity
HV045_07250	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV045_07255	COG1069	ribulokinase activity
HV045_07265	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_07270	COG1129	ABC transporter
HV045_07280	COG3683	transport system, periplasmic component
HV045_07285	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV045_07310	COG0822	iron-sulfur transferase activity
HV045_07330	COG0633	Ferredoxin
HV045_07335	COG2975	iron-sulfur cluster assembly
HV045_07350	COG2897	thiosulfate sulfurtransferase activity
HV045_07355	COG2373	Large extracellular alpha-helical protein
HV045_07360	COG4953	penicillin-binding protein 1C
HV045_07390	COG2976	Protein conserved in bacteria
HV045_07405	COG3104	oligopeptide transport
HV045_07415	COG1645	bacterial-type flagellum-dependent swarming motility
HV045_07420	COG1570	exodeoxyribonuclease VII activity
HV045_07425	COG0516	GMP reductase activity
HV045_07425	COG0517	IMP dehydrogenase activity
HV045_07440	COG2200	EAL domain
HV045_07455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV045_07465	COG2723	6-phospho-beta-galactosidase activity
HV045_07475	COG2233	PERMEase
HV045_07485	COG1393	Belongs to the ArsC family
HV045_07490	COG4783	chaperone-mediated protein folding
HV045_07495	COG0628	permease
HV045_07500	COG3366	ferrous iron transmembrane transporter activity
HV045_07505	COG0700	Nucleoside recognition
HV045_07510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV045_07515	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV045_07520	COG2716	regulation of RNA biosynthetic process
HV045_07530	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV045_07540	COG2321	neutral zinc metallopeptidase
HV045_07550	COG0400	carboxylic ester hydrolase activity
HV045_07565	COG1393	Belongs to the ArsC family
HV045_07580	COG3850	Histidine kinase
HV045_07585	COG0493	'glutamate synthase
HV045_07585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV045_07595	COG5342	invasion associated locus B
HV045_07600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV045_07620	COG4766	ethanolamine catabolic process
HV045_07625	COG4812	Cobalamin adenosyltransferase
HV045_07690	COG2207	Transcriptional regulator
HV045_07700	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV045_07720	COG2837	iron assimilation
HV045_07725	COG0165	Argininosuccinate lyase
HV045_07735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV045_07740	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV045_07745	COG2186	Transcriptional regulator
HV045_07755	COG4150	thiosulfate binding
HV045_07760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV045_07765	COG4208	sulfate ABC transporter
HV045_07770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV045_07835	COG3530	Putative quorum-sensing-regulated virulence factor
HV045_07840	COG0385	Bile acid
HV045_07845	COG0583	DNA-binding transcription factor activity
HV045_07880	COG3415	Transposase
HV045_07885	COG3415	Transposase
HV045_07900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV045_07915	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV045_07920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV045_07925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_07925	COG1263	PTS System
HV045_07935	COG0667	Aldo Keto reductase
HV045_07940	COG3961	Belongs to the TPP enzyme family
HV045_07960	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_07965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_07970	COG0006	proline dipeptidase activity
HV045_07975	COG1363	Peptidase, m42
HV045_07990	COG2207	Transcriptional regulator
HV045_07995	COG3279	Response regulator of the LytR AlgR family
HV045_08000	COG3275	phosphorelay sensor kinase activity
HV045_08005	COG0436	Aminotransferase
HV045_08020	COG1560	Kdo2-lipid A biosynthetic process
HV045_08050	COG3122	Protein conserved in bacteria
HV045_08055	COG0840	transmembrane signaling receptor activity
HV045_08060	COG1446	asparaginase
HV045_08115	COG0582	viral genome integration into host DNA
HV045_08125	COG0582	viral genome integration into host DNA
HV045_08275	COG3179	chitinase
HV045_08305	COG4626	Terminase
HV045_08305	COG1802	Transcriptional regulator
HV045_08315	COG4695	Portal protein
HV045_08425	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV045_08440	COG2116	formate transmembrane transporter activity
HV045_08450	COG2067	long-chain fatty acid transport protein
HV045_08455	COG3691	Protein conserved in bacteria
HV045_08470	COG2062	phosphohistidine phosphatase, SixA
HV045_08495	COG0730	response to heat
HV045_08500	COG3101	peptidyl-lysine hydroxylation
HV045_08515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV045_08555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV045_08565	COG0586	Pfam SNARE associated Golgi protein
HV045_08575	COG0285	dihydrofolate synthase activity
HV045_08580	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV045_08585	COG1286	toxin biosynthetic process
HV045_08590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV045_08595	COG0163	prenyltransferase activity
HV045_08605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV045_08620	COG4598	ABC transporter
HV045_08625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV045_08630	COG1090	epimerase
HV045_08635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV045_08640	COG0625	glutathione transferase activity
HV045_08645	COG0625	glutathione transferase activity
HV045_08650	COG0622	Phosphoesterase
HV045_08660	COG1288	antiporter activity
HV045_08685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV045_08690	COG0490	domain, Protein
HV045_08690	COG0471	metal ion transport
HV045_08700	COG0436	Aminotransferase
HV045_08705	COG0583	DNA-binding transcription factor activity
HV045_08725	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV045_08750	COG0839	Belongs to the complex I subunit 6 family
HV045_08760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV045_08765	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV045_08775	COG0835	chemotaxis
HV045_08775	COG0784	Response regulator, receiver
HV045_08785	COG2153	protein acetylation
HV045_08790	COG4575	ribosome binding
HV045_08795	COG1169	isochorismate synthase
HV045_08805	COG2801	Transposase and inactivated derivatives
HV045_08890	COG1414	Transcriptional regulator
HV045_08900	COG2271	Major facilitator Superfamily
HV045_08920	COG0247	lactate metabolic process
HV045_08930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV045_08940	COG2826	transposase and inactivated derivatives, IS30 family
HV045_08950	COG0584	glycerophosphoryl diester phosphodiesterase
HV045_08955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV045_08980	COG0183	Belongs to the thiolase family
HV045_08985	COG2031	fatty acid transporter
HV045_08990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV045_08995	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV045_09000	COG2204	response regulator
HV045_09005	COG3852	Histidine kinase
HV045_09020	COG0642	Histidine kinase
HV045_09020	COG2198	Histidine kinase
HV045_09030	COG1477	protein flavinylation
HV045_09035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV045_09035	COG2169	Transcriptional regulator
HV045_09040	COG3145	DNA-N1-methyladenine dioxygenase activity
HV045_09045	COG4615	Cyclic peptide transporter
HV045_09050	COG2239	Acts as a magnesium transporter
HV045_09055	COG0659	secondary active sulfate transmembrane transporter activity
HV045_09070	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV045_09070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV045_09075	COG3062	negative regulation of establishment of protein localization
HV045_09085	COG0437	4 iron, 4 sulfur cluster binding
HV045_09090	COG0348	domain, Protein
HV045_09095	COG3043	anaerobic respiration
HV045_09100	COG3005	denitrification pathway
HV045_09105	COG4133	protoheme IX ABC transporter activity
HV045_09115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV045_09120	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV045_09130	COG1138	Cytochrome C-type biogenesis protein
HV045_09135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV045_09140	COG4235	cytochrome complex assembly
HV045_09140	COG3088	subunit of a heme lyase
HV045_09145	COG2197	response regulator
HV045_09175	COG1061	Type III restriction enzyme res subunit
HV045_09180	COG1187	pseudouridine synthase activity
HV045_09185	COG2814	Major facilitator Superfamily
HV045_09195	COG4172	Belongs to the ABC transporter superfamily
HV045_09200	COG4239	(ABC) transporter, permease
HV045_09205	COG4174	ABC transporter (Permease)
HV045_09210	COG4166	transmembrane transport
HV045_09215	COG2200	EAL domain
HV045_09220	COG0791	NLP P60 protein
HV045_09225	COG0671	phosphoesterase, PA-phosphatase related
HV045_09230	COG0523	cobalamin synthesis protein
HV045_09235	COG0246	Mannitol dehydrogenase
HV045_09240	COG1312	Catalyzes the dehydration of D-mannonate
HV045_09245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV045_09250	COG3005	denitrification pathway
HV045_09260	COG3381	protein complex oligomerization
HV045_09285	COG1105	Belongs to the carbohydrate kinase PfkB family
HV045_09290	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV045_09290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_09290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_09295	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV045_09305	COG0583	DNA-binding transcription factor activity
HV045_09310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_09315	COG2313	pseudouridylate synthase activity
HV045_09320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV045_09325	COG1522	sequence-specific DNA binding
HV045_09325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_09335	COG2855	membrane
HV045_09340	COG0583	DNA-binding transcription factor activity
HV045_09345	COG0833	amino acid
HV045_09350	COG4771	TonB-dependent receptor
HV045_09365	COG2311	Membrane
HV045_09380	COG1129	ABC transporter
HV045_09395	COG0493	'glutamate synthase
HV045_09405	COG2949	membrane
HV045_09415	COG1346	cytolysis
HV045_09430	COG2271	Major facilitator Superfamily
HV045_09445	COG0625	glutathione transferase activity
HV045_09450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV045_09455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV045_09460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV045_09470	COG0586	Pfam SNARE associated Golgi protein
HV045_09480	COG1686	Belongs to the peptidase S11 family
HV045_09485	COG0277	FAD linked oxidase domain protein
HV045_09490	COG1472	Belongs to the glycosyl hydrolase 3 family
HV045_09495	COG1732	Glycine betaine
HV045_09500	COG1174	glycine betaine transport
HV045_09505	COG1125	glycine betaine transport
HV045_09510	COG1174	glycine betaine transport
HV045_09520	COG0789	Transcriptional regulator
HV045_09525	COG3275	phosphorelay sensor kinase activity
HV045_09535	COG4807	Protein conserved in bacteria
HV045_09540	COG4808	Protein conserved in bacteria
HV045_09565	COG3121	Chaperone
HV045_09570	COG3188	usher protein
HV045_09580	COG5455	response to cobalt ion
HV045_09590	COG0351	phosphomethylpyrimidine kinase
HV045_09595	COG2188	Transcriptional regulator
HV045_09600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_09605	COG1397	ADP-ribosylglycohydrolase
HV045_09610	COG2211	Major facilitator Superfamily
HV045_09615	COG1830	Aldolase
HV045_09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV045_09630	COG4160	amino acid transport
HV045_09635	COG4215	(ABC) transporter
HV045_09640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV045_09645	COG1126	abc transporter atp-binding protein
HV045_09660	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV045_09665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV045_09670	COG0702	epimerase
HV045_09675	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV045_09680	COG0028	Belongs to the TPP enzyme family
HV045_09690	COG4529	Protein conserved in bacteria
HV045_09695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV045_09705	COG2431	L-lysine efflux transmembrane transporter activity
HV045_09715	COG3593	DNA synthesis involved in DNA repair
HV045_09720	COG2990	Protein conserved in bacteria
HV045_09725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV045_09735	COG1278	Cold shock
HV045_09745	COG0542	response to heat
HV045_09760	COG0745	RESPONSE REGULATOR receiver
HV045_09765	COG2205	protein histidine kinase activity
HV045_09795	COG0443	Heat shock 70 kDa protein
HV045_09800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV045_09805	COG3447	MASE1 domain protein
HV045_09805	COG5002	protein histidine kinase activity
HV045_09805	COG5001	Diguanylate cyclase
HV045_09820	COG2982	Protein involved in outer membrane biogenesis
HV045_09825	COG1253	flavin adenine dinucleotide binding
HV045_09845	COG0463	Glycosyl transferase, family 2
HV045_09850	COG1045	serine acetyltransferase
HV045_09855	COG0438	transferase activity, transferring glycosyl groups
HV045_09865	COG1216	Glycosyl transferase, family 2
HV045_09870	COG0110	maltose O-acetyltransferase activity
HV045_09875	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV045_09880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV045_09885	COG1051	belongs to the nudix hydrolase family
HV045_09890	COG0297	glycogen (starch) synthase activity
HV045_09895	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HV045_09895	COG0662	Cupin 2, conserved barrel domain protein
HV045_09900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV045_09905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV045_09910	COG2244	polysaccharide biosynthetic process
HV045_09915	COG2327	Polysaccharide pyruvyl transferase
HV045_10010	COG3344	reverse transcriptase
HV045_10025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV045_10045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV045_10075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV045_10080	COG0583	DNA-binding transcription factor activity
HV045_10090	COG0531	amino acid
HV045_10095	COG2925	Exonuclease
HV045_10125	COG1289	transmembrane transporter activity
HV045_10160	COG4656	Part of a membrane complex involved in electron transport
HV045_10350	COG1376	ErfK ybiS ycfS ynhG family protein
HV045_10360	COG1178	ABC-type Fe3 transport system permease component
HV045_10365	COG1840	ABC-type Fe3 transport system, periplasmic component
HV045_10480	COG0210	DNA helicase
HV045_10485	COG0582	viral genome integration into host DNA
HV045_10525	COG1418	mRNA catabolic process
HV045_10530	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV045_10535	COG3727	T/G mismatch-specific endonuclease activity
HV045_10540	COG0697	spore germination
HV045_10545	COG2354	Protein conserved in bacteria
HV045_10550	COG5475	Uncharacterized small protein (DUF2158)
HV045_10610	COG2882	bacterial-type flagellum organization
HV045_10640	COG0425	Belongs to the sulfur carrier protein TusA family
HV045_10655	COG0366	Alpha amylase catalytic
HV045_10700	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HV045_10715	COG2197	response regulator
HV045_10725	COG2197	response regulator
HV045_10790	COG3596	GTP binding
HV045_10840	COG3039	Transposase
HV045_10855	COG3344	reverse transcriptase
HV045_10870	COG1278	Cold shock
HV045_10890	COG0431	NADPH-dependent FMN reductase
HV045_10895	COG0640	Transcriptional regulator
HV045_10925	COG1305	Transglutaminase-like
HV045_10935	COG2608	mercury ion transmembrane transporter activity
HV045_10940	COG3012	SEC-C Motif Domain Protein
HV045_10940	COG3318	Belongs to the UPF0149 family
HV045_10945	COG0814	amino acid
HV045_10955	COG1528	Iron-storage protein
HV045_10970	COG0477	Major facilitator Superfamily
HV045_10980	COG1528	Iron-storage protein
HV045_10990	COG1879	ABC-type sugar transport system periplasmic component
HV045_10995	COG1129	ABC transporter
HV045_11000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_11045	COG0835	chemotaxis
HV045_11050	COG1301	dicarboxylic acid transport
HV045_11060	COG0840	transmembrane signaling receptor activity
HV045_11075	COG0745	RESPONSE REGULATOR receiver
HV045_11085	COG4977	sequence-specific DNA binding
HV045_11090	COG2814	Major facilitator Superfamily
HV045_11095	COG3250	beta-galactosidase activity
HV045_11120	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV045_11135	COG3102	Protein conserved in bacteria
HV045_11155	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV045_11160	COG1801	Protein of unknown function DUF72
HV045_11165	COG1335	isochorismatase
HV045_11175	COG0494	nUDIX hydrolase
HV045_11195	COG2255	four-way junction helicase activity
HV045_11200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV045_11220	COG1187	pseudouridine synthase activity
HV045_11225	COG0538	isocitrate dehydrogenase activity
HV045_11230	COG2814	Major facilitator Superfamily
HV045_11235	COG1414	Transcriptional regulator
HV045_11265	COG0768	penicillin binding
HV045_11270	COG2226	methyltransferase
HV045_11285	COG3716	PTS system mannose fructose sorbose family IID component
HV045_11290	COG3715	PTS system
HV045_11295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_11295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_11300	COG1253	flavin adenine dinucleotide binding
HV045_11305	COG2200	EAL domain
HV045_11310	COG1760	l-serine dehydratase
HV045_11330	COG0251	oxidation-reduction process
HV045_11335	COG1199	ATP-dependent helicase activity
HV045_11340	COG1214	PFAM Peptidase M22, glycoprotease
HV045_11345	COG3065	identical protein binding
HV045_11350	COG0318	PFAM AMP-dependent synthetase and ligase
HV045_11355	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV045_11360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV045_11365	COG4638	Rieske (2fe-2S)
HV045_11370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV045_11375	COG0473	3-isopropylmalate dehydrogenase activity
HV045_11380	COG0583	DNA-binding transcription factor activity
HV045_11390	COG2894	cell division
HV045_11405	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV045_11435	COG2719	SpoVR family
HV045_11445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV045_11455	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV045_11480	COG0157	Belongs to the NadC ModD family
HV045_11485	COG0500	methyltransferase
HV045_11490	COG1120	ATPase activity
HV045_11515	COG1461	Dihydroxyacetone kinase
HV045_11520	COG2376	Dihydroxyacetone kinase
HV045_11525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV045_11550	COG0789	Transcriptional regulator
HV045_11555	COG2200	EAL domain
HV045_11585	COG0702	epimerase
HV045_11595	COG0667	Aldo Keto reductase
HV045_11600	COG0656	L-ascorbic acid biosynthetic process
HV045_11605	COG0641	radical SAM
HV045_11610	COG2190	(PTS) system
HV045_11610	COG1263	PTS System
HV045_11610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_11625	COG1737	Transcriptional regulator
HV045_11630	COG2149	membrane
HV045_11670	COG5002	protein histidine kinase activity
HV045_11730	COG1396	sequence-specific DNA binding
HV045_11745	COG2003	Belongs to the UPF0758 family
HV045_11750	COG4974	Belongs to the 'phage' integrase family
HV045_11815	COG0582	viral genome integration into host DNA
HV045_11820	COG0012	GTP binding
HV045_11835	COG0527	aspartate kinase activity
HV045_11840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV045_11845	COG0076	glutamate decarboxylase activity
HV045_11850	COG0659	secondary active sulfate transmembrane transporter activity
HV045_11880	COG2890	protein-(glutamine-N5) methyltransferase activity
HV045_11900	COG0387	Pfam Sodium calcium exchanger
HV045_11905	COG4572	Cation transport regulator
HV045_11910	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV045_11920	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV045_11925	COG4932	domain protein
HV045_11930	COG2197	response regulator
HV045_11935	COG3850	Histidine kinase
HV045_11940	COG2223	nitrite transmembrane transporter activity
HV045_11945	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV045_11950	COG1140	nitrate reductase beta subunit
HV045_11955	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV045_11960	COG2181	nitrate reductase activity
HV045_11980	COG0788	formyltetrahydrofolate deformylase activity
HV045_11990	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV045_11995	COG0745	RESPONSE REGULATOR receiver
HV045_12000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV045_12010	COG1435	thymidine kinase activity
HV045_12015	COG1454	alcohol dehydrogenase
HV045_12015	COG1012	belongs to the aldehyde dehydrogenase family
HV045_12020	COG2095	MarC family integral membrane protein
HV045_12040	COG0444	Belongs to the ABC transporter superfamily
HV045_12050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV045_12070	COG2350	Protein conserved in bacteria
HV045_12095	COG3047	cAMP biosynthetic process
HV045_12105	COG3706	GGDEF domain
HV045_12140	COG0613	PHP domain protein
HV045_12145	COG0009	L-threonylcarbamoyladenylate synthase
HV045_12150	COG1187	pseudouridine synthase activity
HV045_12160	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_12165	COG0616	signal peptide processing
HV045_12180	COG0583	DNA-binding transcription factor activity
HV045_12195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV045_12205	COG0671	phosphoesterase, PA-phosphatase related
HV045_12210	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV045_12215	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV045_12225	COG0023	Translation Initiation Factor
HV045_12235	COG1349	DNA-binding transcription factor activity
HV045_12245	COG5001	Diguanylate cyclase
HV045_12255	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV045_12255	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV045_12260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV045_12280	COG4172	Belongs to the ABC transporter superfamily
HV045_12285	COG4171	peptide transport system, permease
HV045_12300	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_12305	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV045_12310	COG1842	Phage shock protein A
HV045_12320	COG1983	PspC domain protein
HV045_12330	COG0366	Alpha amylase catalytic
HV045_12335	COG1653	transport
HV045_12340	COG1175	transmembrane transport
HV045_12345	COG0395	ABC-type sugar transport system, permease component
HV045_12350	COG1063	alcohol dehydrogenase
HV045_12355	COG1082	Xylose isomerase domain protein TIM barrel
HV045_12360	COG0673	inositol 2-dehydrogenase activity
HV045_12365	COG1554	hydrolase, family 65, central catalytic
HV045_12370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV045_12385	COG1609	Transcriptional regulator
HV045_12390	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV045_12395	COG3106	COG3106 Predicted ATPase
HV045_12410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV045_12415	COG4948	Mandelate Racemase Muconate Lactonizing
HV045_12420	COG2866	Carboxypeptidase
HV045_12425	COG4166	transmembrane transport
HV045_12430	COG1349	DNA-binding transcription factor activity
HV045_12435	COG0346	lactoylglutathione lyase activity
HV045_12450	COG0668	transmembrane transport
HV045_12455	COG3182	Iron-regulated membrane protein
HV045_12475	COG2840	Smr protein MutS2
HV045_12480	COG3706	GGDEF domain
HV045_12490	COG0840	transmembrane signaling receptor activity
HV045_12505	COG0513	Belongs to the DEAD box helicase family
HV045_12515	COG0589	response to stress
HV045_12525	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV045_12530	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV045_12530	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV045_12530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV045_12530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV045_12535	COG3042	response to heat
HV045_12540	COG3187	Heat shock protein
HV045_12545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV045_12560	COG3784	Protein of unknown function (DUF1318)
HV045_12565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV045_12570	COG4589	Belongs to the CDS family
HV045_12580	COG2267	carboxylic ester hydrolase activity
HV045_12585	COG2453	phosphatase
HV045_12585	COG0671	phosphoesterase, PA-phosphatase related
HV045_12605	COG1643	Atp-dependent helicase
HV045_12610	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV045_12615	COG1012	belongs to the aldehyde dehydrogenase family
HV045_12620	COG3038	cytochrome b561
HV045_12625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV045_12630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV045_12650	COG0840	transmembrane signaling receptor activity
HV045_12655	COG0583	DNA-binding transcription factor activity
HV045_12665	COG5383	Protein conserved in bacteria
HV045_12675	COG2841	Protein conserved in bacteria
HV045_12680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV045_12685	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV045_12700	COG4644	lycopene metabolic process
HV045_12710	COG0500	methyltransferase
HV045_12720	COG0697	spore germination
HV045_12730	COG3135	benzoate transporter
HV045_12735	COG1396	sequence-specific DNA binding
HV045_12740	COG0826	peptidase U32
HV045_12755	COG1294	oxidase, subunit
HV045_12760	COG1271	oxidase subunit
HV045_12765	COG1724	mRNA binding
HV045_12770	COG1598	PFAM Uncharacterised protein family UPF0150
HV045_12775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV045_12780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV045_12785	COG3842	ATPase activity
HV045_12790	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV045_12795	COG1177	transmembrane transport
HV045_12805	COG2814	Major facilitator Superfamily
HV045_12840	COG0747	negative chemotaxis
HV045_12850	COG3238	Protein conserved in bacteria
HV045_12855	COG1247	-acetyltransferase
HV045_12865	COG2130	NADP-dependent
HV045_12870	COG4772	TonB-dependent receptor
HV045_12895	COG3039	Transposase
HV045_12900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV045_12905	COG1473	amidohydrolase
HV045_12910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV045_12915	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV045_12930	COG1126	abc transporter atp-binding protein
HV045_12935	COG0625	glutathione transferase activity
HV045_12940	COG2271	Major facilitator Superfamily
HV045_12950	COG1609	Transcriptional regulator
HV045_12960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV045_12965	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV045_12970	COG0384	phenazine biosynthesis protein PhzF
HV045_12975	COG2181	nitrate reductase activity
HV045_12980	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV045_12985	COG1140	nitrate reductase beta subunit
HV045_12990	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV045_12995	COG2223	nitrite transmembrane transporter activity
HV045_13030	COG0437	4 iron, 4 sulfur cluster binding
HV045_13035	COG2864	formate dehydrogenase
HV045_13070	COG1764	response to oxidative stress
HV045_13075	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_13080	COG2610	gluconate transmembrane transporter activity
HV045_13085	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV045_13085	COG0824	Thioesterase
HV045_13095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV045_13100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV045_13110	COG4608	Belongs to the ABC transporter superfamily
HV045_13115	COG0444	Belongs to the ABC transporter superfamily
HV045_13120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV045_13125	COG0601	transmembrane transport
HV045_13130	COG0747	negative chemotaxis
HV045_13135	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV045_13150	COG0840	transmembrane signaling receptor activity
HV045_13160	COG4628	conserved protein (DUF2132)
HV045_13175	COG2801	Transposase and inactivated derivatives
HV045_13190	COG3781	membrane
HV045_13215	COG1012	belongs to the aldehyde dehydrogenase family
HV045_13220	COG0583	DNA-binding transcription factor activity
HV045_13235	COG1846	Transcriptional regulator
HV045_13250	COG0697	spore germination
HV045_13255	COG2814	Major facilitator Superfamily
HV045_13260	COG0410	ABC transporter
HV045_13265	COG1129	ABC transporter
HV045_13290	COG0339	signal peptide processing
HV045_13295	COG4221	oxidoreductase activity
HV045_13300	COG1802	Transcriptional regulator
HV045_13310	COG0246	Mannitol dehydrogenase
HV045_13315	COG0477	Major facilitator Superfamily
HV045_13320	COG1063	alcohol dehydrogenase
HV045_13325	COG4948	Mandelate Racemase Muconate Lactonizing
HV045_13340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV045_13355	COG0243	molybdopterin cofactor binding
HV045_13360	COG0437	4 iron, 4 sulfur cluster binding
HV045_13365	COG3302	dmso reductase anchor subunit
HV045_13370	COG3381	protein complex oligomerization
HV045_13380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV045_13385	COG1940	carbohydrate kinase activity
HV045_13390	COG0583	DNA-binding transcription factor activity
HV045_13395	COG2814	Major facilitator Superfamily
HV045_13405	COG5002	protein histidine kinase activity
HV045_13410	COG0745	RESPONSE REGULATOR receiver
HV045_13425	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV045_13435	COG3591	Belongs to the peptidase S1B family
HV045_13450	COG0628	permease
HV045_13455	COG2814	Major facilitator Superfamily
HV045_13460	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV045_13465	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV045_13475	COG0531	amino acid
HV045_13485	COG3136	membrane protein required for alginate biosynthesis
HV045_13490	COG0745	RESPONSE REGULATOR receiver
HV045_13495	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV045_13505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV045_13515	COG2205	protein histidine kinase activity
HV045_13530	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_13530	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_13535	COG1482	cell wall glycoprotein biosynthetic process
HV045_13540	COG5339	Protein conserved in bacteria
HV045_13545	COG1609	Transcriptional regulator
HV045_13550	COG1263	PTS System
HV045_13550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_13555	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV045_13565	COG0673	inositol 2-dehydrogenase activity
HV045_13615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV045_13625	COG0625	glutathione transferase activity
HV045_13630	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV045_13645	COG3895	Periplasmic Protein
HV045_13670	COG1566	PFAM secretion protein HlyD family protein
HV045_13685	COG4989	oxidoreductase activity
HV045_13690	COG3313	Fe-S protein
HV045_13695	COG1309	transcriptional regulator
HV045_13700	COG1902	pentaerythritol trinitrate reductase activity
HV045_13705	COG0346	lactoylglutathione lyase activity
HV045_13715	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV045_13720	COG0791	NLP P60 protein
HV045_13725	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV045_13730	COG2814	Major facilitator Superfamily
HV045_13745	COG0583	DNA-binding transcription factor activity
HV045_13750	COG2814	Major facilitator Superfamily
HV045_13760	COG0307	riboflavin synthase, alpha
HV045_13770	COG0564	pseudouridine synthase activity
HV045_13785	COG0251	oxidation-reduction process
HV045_13805	COG3300	MHYT domain
HV045_13805	COG5001	Diguanylate cyclase
HV045_13810	COG3272	Protein of unknown function (DUF1722)
HV045_13815	COG0628	permease
HV045_13835	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_13845	COG0583	DNA-binding transcription factor activity
HV045_13850	COG0477	Major facilitator Superfamily
HV045_13865	COG1942	4-Oxalocrotonate Tautomerase
HV045_13875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV045_13915	COG4977	sequence-specific DNA binding
HV045_13925	COG0386	Belongs to the glutathione peroxidase family
HV045_13960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV045_13975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV045_13985	COG1012	belongs to the aldehyde dehydrogenase family
HV045_14000	COG1113	amino acid transport
HV045_14010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV045_14020	COG0765	amino acid transport
HV045_14025	COG0765	amino acid transport
HV045_14035	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV045_14040	COG0437	4 iron, 4 sulfur cluster binding
HV045_14050	COG2414	aldehyde ferredoxin oxidoreductase
HV045_14055	COG0437	4 iron, 4 sulfur cluster binding
HV045_14090	COG1464	Belongs to the NlpA lipoprotein family
HV045_14095	COG2011	ABC-type metal ion transport system permease component
HV045_14115	COG1376	ErfK ybiS ycfS ynhG family protein
HV045_14130	COG0719	Fe-S assembly protein
HV045_14135	COG0396	ATPase activity
HV045_14140	COG0719	Fe-S assembly protein
HV045_14145	COG0316	Belongs to the HesB IscA family
HV045_14175	COG2050	protein possibly involved in aromatic compounds catabolism
HV045_14180	COG0277	FAD linked oxidase domain protein
HV045_14180	COG0247	lactate metabolic process
HV045_14185	COG0628	permease
HV045_14200	COG0738	Major facilitator superfamily
HV045_14205	COG2271	Major facilitator Superfamily
HV045_14220	COG4670	ketone body catabolic process
HV045_14225	COG1960	acyl-CoA dehydrogenase activity
HV045_14230	COG1917	Cupin 2, conserved barrel domain protein
HV045_14230	COG2207	Transcriptional regulator
HV045_14235	COG2086	electron transfer activity
HV045_14240	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV045_14245	COG0644	oxidoreductase
HV045_14250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV045_14255	COG0318	PFAM AMP-dependent synthetase and ligase
HV045_14260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV045_14260	COG0574	Belongs to the PEP-utilizing enzyme family
HV045_14270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV045_14275	COG4256	Hemin uptake protein
HV045_14280	COG4771	TonB-dependent receptor
HV045_14285	COG3720	iron ion transport
HV045_14290	COG4558	Periplasmic binding protein
HV045_14295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV045_14315	COG0791	NLP P60 protein
HV045_14325	COG0386	Belongs to the glutathione peroxidase family
HV045_14340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_14355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV045_14385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV045_14405	COG3137	Salt-induced outer membrane protein
HV045_14410	COG1105	Belongs to the carbohydrate kinase PfkB family
HV045_14415	COG3001	Fructosamine kinase
HV045_14425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV045_14430	COG1988	membrane-bound metal-dependent
HV045_14445	COG0753	catalase activity
HV045_14455	COG1486	melibiose metabolic process
HV045_14460	COG2169	Transcriptional regulator
HV045_14460	COG1917	Cupin 2, conserved barrel domain protein
HV045_14465	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV045_14470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV045_14475	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV045_14480	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV045_14490	COG0322	excinuclease ABC activity
HV045_14500	COG3678	ATP-independent chaperone mediated protein folding
HV045_14530	COG0708	Exodeoxyribonuclease III
HV045_14535	COG0398	Pfam SNARE associated Golgi protein
HV045_14540	COG0398	Pfam SNARE associated Golgi protein
HV045_14545	COG4134	Bacterial extracellular solute-binding protein
HV045_14550	COG4135	transport system, permease component
HV045_14555	COG4136	ATPase activity
HV045_14560	COG2897	thiosulfate sulfurtransferase activity
HV045_14565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV045_14570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV045_14575	COG0494	nUDIX hydrolase
HV045_14590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV045_14600	COG0778	Nitroreductase
HV045_14605	COG0616	signal peptide processing
HV045_14610	COG0252	asparaginase activity
HV045_14615	COG1335	isochorismatase
HV045_14630	COG3139	Protein of unknown function (DUF1315)
HV045_14650	COG0656	L-ascorbic acid biosynthetic process
HV045_14665	COG3713	MltA-interacting MipA family protein
HV045_14670	COG2766	serine protein kinase
HV045_14680	COG0110	maltose O-acetyltransferase activity
HV045_14690	COG2226	methyltransferase
HV045_14695	COG2199	diguanylate cyclase activity
HV045_14700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV045_14710	COG2207	Transcriptional regulator
HV045_14715	COG2807	transmembrane transport
HV045_14720	COG0504	CTP synthase activity
HV045_14725	COG3189	MarR family transcriptional regulator
HV045_14730	COG3042	response to heat
HV045_14735	COG2199	diguanylate cyclase activity
HV045_14735	COG2203	Gaf domain
HV045_14750	COG2261	transglycosylase associated protein
HV045_14755	COG3383	formate dehydrogenase (NAD+) activity
HV045_14770	COG3615	Tellurite resistance protein tehB
HV045_14780	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV045_14795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV045_14800	COG0601	transmembrane transport
HV045_14805	COG0747	negative chemotaxis
HV045_14810	COG4771	TonB-dependent receptor
HV045_14830	COG1956	GAF domain-containing protein
HV045_14835	COG2995	paraquat-inducible protein a
HV045_14840	COG3008	intermembrane lipid transfer
HV045_14875	COG2135	peptidase activity
HV045_14880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV045_14955	COG1196	nuclear chromosome segregation
HV045_15140	COG1484	DNA-dependent DNA replication
HV045_15170	COG3039	Transposase
HV045_15210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV045_15240	COG0582	viral genome integration into host DNA
HV045_15250	COG1276	copper resistance
HV045_15255	COG2372	response to copper ion
HV045_15265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV045_15270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV045_15275	COG1770	oligopeptidase
HV045_15280	COG2979	Protein of unknown function (DUF533)
HV045_15290	COG3141	response to X-ray
HV045_15300	COG0800	Aldolase
HV045_15305	COG0129	dihydroxy-acid dehydratase activity
HV045_15310	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV045_15315	COG1737	Transcriptional regulator
HV045_15325	COG1560	Kdo2-lipid A biosynthetic process
HV045_15330	COG0739	heme binding
HV045_15335	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV045_15345	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV045_15355	COG2826	transposase and inactivated derivatives, IS30 family
HV045_15380	COG0582	viral genome integration into host DNA
HV045_15390	COG0582	viral genome integration into host DNA
HV045_15415	COG2850	peptidyl-arginine hydroxylation
HV045_15440	COG3459	Glycosyltransferase 36 associated
HV045_15475	COG1289	transmembrane transporter activity
HV045_15490	COG1278	Cold shock
HV045_15505	COG1177	transmembrane transport
HV045_15515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV045_15525	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV045_15530	COG1136	(ABC) transporter
HV045_15535	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV045_15540	COG4763	Acyl-transferase
HV045_15545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV045_15550	COG1376	ErfK ybiS ycfS ynhG family protein
HV045_15550	COG1388	LysM domain
HV045_15560	COG1309	transcriptional regulator
HV045_15570	COG3134	Outer membrane lipoprotein
HV045_15575	COG1252	NADH dehydrogenase
HV045_15600	COG5633	Lipoprotein
HV045_15605	COG0537	adenosine 5'-monophosphoramidase activity
HV045_15610	COG4773	Receptor
HV045_15620	COG0534	Mate efflux family protein
HV045_15630	COG0582	viral genome integration into host DNA
HV045_15655	COG3423	Transcriptional regulator
HV045_15665	COG3039	Transposase
HV045_15680	COG0583	DNA-binding transcription factor activity
HV045_15700	COG0477	Major facilitator Superfamily
HV045_15705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV045_15710	COG0006	proline dipeptidase activity
HV045_15720	COG0084	hydrolase, TatD family'
HV045_15725	COG0470	DNA polymerase III
HV045_15735	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV045_15740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV045_15745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV045_15780	COG1399	metal-binding, possibly nucleic acid-binding protein
HV045_15790	COG0564	pseudouridine synthase activity
HV045_15795	COG1530	ribonuclease E activity
HV045_15825	COG4786	Flagellar basal body rod
HV045_15830	COG4787	bacterial-type flagellum-dependent cell motility
HV045_15845	COG1558	bacterial-type flagellum-dependent cell motility
HV045_15885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV045_15925	COG3038	cytochrome b561
HV045_15940	COG1560	Kdo2-lipid A biosynthetic process
HV045_15955	COG5645	(Lipo)protein
HV045_15975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV045_15990	COG3039	Transposase
HV045_16035	COG3381	protein complex oligomerization
HV045_16060	COG1702	phosphate starvation-inducible protein PhoH
HV045_16085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV045_16090	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV045_16090	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV045_16090	COG0506	proline dehydrogenase activity
HV045_16095	COG3755	Protein conserved in bacteria
HV045_16100	COG1309	transcriptional regulator
HV045_16110	COG3729	General stress protein
HV045_16130	COG0640	Transcriptional regulator
HV045_16140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV045_16145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV045_16145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV045_16195	COG0813	purine-nucleoside phosphorylase activity
HV045_16215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV045_16220	COG1120	ATPase activity
HV045_16235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HV045_16235	COG2857	Cytochrome c1
HV045_16250	COG4166	transmembrane transport
HV045_16255	COG0670	Belongs to the BI1 family
HV045_16295	COG2920	part of a sulfur-relay system
HV045_16315	COG1832	CoA-binding protein
HV045_16330	COG0210	DNA helicase
HV045_16335	COG3304	Inner membrane component domain
HV045_16340	COG1289	transmembrane transporter activity
HV045_16345	COG3070	regulator of competence-specific genes
HV045_16365	COG1067	ATP-dependent peptidase activity
HV045_16375	COG3130	regulation of translation
HV045_16380	COG3009	Protein conserved in bacteria
HV045_16385	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV045_16385	COG3008	intermembrane lipid transfer
HV045_16390	COG2995	paraquat-inducible protein a
HV045_16395	COG0488	(ABC) transporter
HV045_16405	COG0633	Ferredoxin
HV045_16405	COG3217	Mosc domain protein beta barrel domain protein
HV045_16420	COG0431	NADPH-dependent FMN reductase
HV045_16425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV045_16435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV045_16445	COG0308	aminopeptidase N
HV045_16465	COG1448	Aminotransferase
HV045_16470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV045_16475	COG3108	Peptidase M15
HV045_16480	COG2989	Protein conserved in bacteria
HV045_16490	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV045_16500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV045_16505	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV045_16510	COG3173	Aminoglycoside phosphotransferase
HV045_16525	COG3214	Protein conserved in bacteria
HV045_16540	COG2333	competence protein COMEC
HV045_16540	COG0658	competence protein
HV045_16545	COG0776	regulation of translation
HV045_16550	COG0539	negative regulation of cytoplasmic translation
HV045_16570	COG2323	membrane
HV045_16575	COG1944	ATP diphosphatase activity
HV045_16580	COG2116	formate transmembrane transporter activity
HV045_16585	COG1882	Formate acetyltransferase
HV045_16590	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV045_16610	COG3959	Transketolase, thiamine diphosphate binding domain
HV045_16615	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV045_16620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_16630	COG1335	isochorismatase
HV045_16635	COG3302	dmso reductase anchor subunit
HV045_16640	COG0437	4 iron, 4 sulfur cluster binding
HV045_16645	COG0243	molybdopterin cofactor binding
HV045_16655	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV045_16665	COG1178	ABC-type Fe3 transport system permease component
HV045_16665	COG1674	ftsk spoiiie
HV045_16675	COG0492	ferredoxin-NADP+ reductase activity
HV045_16680	COG4988	ABC transporter
HV045_16685	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV045_16700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV045_16705	COG0583	DNA-binding transcription factor activity
HV045_16715	COG1335	isochorismatase
HV045_16730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV045_16740	COG1177	transmembrane transport
HV045_16745	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV045_16750	COG3842	ATPase activity
HV045_16755	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV045_16795	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_16800	COG3226	Transcriptional regulator
HV045_16805	COG0738	Major facilitator superfamily
HV045_16810	COG0561	phosphatase activity
HV045_16820	COG2814	Major facilitator Superfamily
HV045_16825	COG0671	phosphoesterase, PA-phosphatase related
HV045_16830	COG1349	DNA-binding transcription factor activity
HV045_16835	COG1686	Belongs to the peptidase S11 family
HV045_16840	COG0625	glutathione transferase activity
HV045_16845	COG2133	pyrroloquinoline quinone binding
HV045_16880	COG1446	asparaginase
HV045_16890	COG0303	'Molybdopterin
HV045_16895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV045_16900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV045_16905	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV045_16910	COG1882	Formate acetyltransferase
HV045_16915	COG0561	phosphatase activity
HV045_16925	COG0488	(ABC) transporter
HV045_16930	COG1376	ErfK ybiS ycfS ynhG family protein
HV045_16935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV045_16950	COG2194	sulfuric ester hydrolase activity
HV045_16955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV045_16970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV045_16975	COG0765	amino acid transport
HV045_16980	COG1126	abc transporter atp-binding protein
HV045_16985	COG0668	transmembrane transport
HV045_17000	COG4774	siderophore transport
HV045_17010	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV045_17020	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV045_17025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV045_17035	COG0513	Belongs to the DEAD box helicase family
HV045_17040	COG1309	transcriptional regulator
HV045_17050	COG1131	(ABC) transporter
HV045_17055	COG0842	Transport permease protein
HV045_17060	COG0842	Transport permease protein
HV045_17070	COG3568	Endonuclease Exonuclease Phosphatase
HV045_17075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV045_17080	COG0392	lysyltransferase activity
HV045_17085	COG0670	Belongs to the BI1 family
HV045_17090	COG0314	molybdopterin synthase activity
HV045_17095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV045_17105	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV045_17120	COG1757	Na H antiporter
HV045_17125	COG0626	cystathionine gamma-synthase activity
HV045_17140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV045_17180	COG1881	PFAM PEBP family protein
HV045_17210	COG4677	pectinesterase activity
HV045_17225	COG2826	transposase and inactivated derivatives, IS30 family
HV045_17235	COG4796	Type ii and iii secretion system protein
HV045_17255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV045_17260	COG1459	type II secretion system
HV045_17265	COG3039	Transposase
HV045_17280	COG1196	nuclear chromosome segregation
HV045_17280	COG0739	heme binding
HV045_17280	COG0741	lytic transglycosylase activity
HV045_17295	COG0561	phosphatase activity
HV045_17305	COG4149	molybdate abc transporter
HV045_17310	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV045_17320	COG3585	molybdate ion transport
HV045_17320	COG2005	Transcriptional regulator
HV045_17325	COG1119	ATPase activity
HV045_17330	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV045_17335	COG1085	galactose-1-phosphate uridylyltransferase
HV045_17345	COG2017	converts alpha-aldose to the beta-anomer
HV045_17355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV045_17365	COG1230	cation diffusion facilitator family transporter
HV045_17370	COG3201	nicotinamide mononucleotide transporter
HV045_17405	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV045_17410	COG2885	chlorophyll binding
HV045_17420	COG3064	Membrane
HV045_17425	COG0848	biopolymer transport protein
HV045_17430	COG0811	peptide transport
HV045_17435	COG0824	Thioesterase
HV045_17440	COG3790	cyd operon protein YbgE
HV045_17445	COG4890	Cyd operon protein YbgT
HV045_17450	COG1294	oxidase, subunit
HV045_17455	COG1271	oxidase subunit
HV045_17460	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV045_17470	COG4865	methylaspartate mutase activity
HV045_17475	COG3799	methylaspartate ammonia-lyase activity
HV045_17490	COG1301	dicarboxylic acid transport
HV045_17500	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_17500	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_17510	COG0583	DNA-binding transcription factor activity
HV045_17515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV045_17515	COG1648	precorrin-2 dehydrogenase activity
HV045_17535	COG3395	kinase activity
HV045_17540	COG0235	Class ii aldolase
HV045_17545	COG1349	DNA-binding transcription factor activity
HV045_17550	COG3622	Belongs to the hyi family
HV045_17555	COG3246	L-lysine catabolic process to acetate
HV045_17575	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV045_17585	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV045_17590	COG0567	Dehydrogenase, E1 component
HV045_17595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV045_17600	COG1053	succinate dehydrogenase
HV045_17605	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV045_17610	COG2009	succinate dehydrogenase
HV045_17620	COG3180	Ammonia monooxygenase
HV045_17650	COG1984	allophanate hydrolase subunit 2
HV045_17655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV045_17670	COG5464	transposase or invertase
HV045_17705	COG2205	protein histidine kinase activity
HV045_17710	COG0745	RESPONSE REGULATOR receiver
HV045_17720	COG1982	Orn Lys Arg decarboxylase major
HV045_17725	COG0531	amino acid
HV045_17730	COG0033	Phosphoglucomutase
HV045_17735	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV045_17740	COG0596	Alpha beta hydrolase
HV045_17750	COG0716	FMN binding
HV045_17760	COG0735	belongs to the Fur family
HV045_17765	COG0583	DNA-binding transcription factor activity
HV045_17770	COG1053	succinate dehydrogenase
HV045_17795	COG1609	Transcriptional regulator
HV045_17805	COG1653	transport
HV045_17815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_17815	COG1263	PTS System
HV045_17815	COG2190	(PTS) system
HV045_17825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV045_17830	COG1940	carbohydrate kinase activity
HV045_17830	COG1846	Transcriptional regulator
HV045_17835	COG0647	UMP catabolic process
HV045_17840	COG0367	asparagine synthase
HV045_17880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV045_17890	COG1702	phosphate starvation-inducible protein PhoH
HV045_17895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV045_17915	COG0765	amino acid transport
HV045_17920	COG0765	amino acid transport
HV045_17925	COG1126	abc transporter atp-binding protein
HV045_17935	COG3039	Transposase
HV045_17950	COG2888	peptidyl-tyrosine sulfation
HV045_17965	COG1466	dna polymerase III delta subunit
HV045_17985	COG0799	negative regulation of ribosome biogenesis
HV045_17995	COG0768	penicillin binding
HV045_18000	COG0772	Belongs to the SEDS family
HV045_18005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV045_18010	COG1686	Belongs to the peptidase S11 family
HV045_18035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV045_18055	COG3069	C4-dicarboxylate transmembrane transporter activity
HV045_18060	COG4565	transcriptional regulatory protein
HV045_18065	COG3290	protein histidine kinase activity
HV045_18070	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV045_18080	COG2301	Belongs to the HpcH HpaI aldolase family
HV045_18085	COG3051	citrate lyase alpha subunit
HV045_18100	COG0471	metal ion transport
HV045_18105	COG3719	Belongs to the RNase T2 family
HV045_18120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV045_18150	COG3634	alkyl hydroperoxide reductase activity
HV045_18160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV045_18165	COG0583	DNA-binding transcription factor activity
HV045_18170	COG3969	phosphoadenosine phosphosulfate
HV045_18175	COG1475	DNA binding
HV045_18180	COG0436	Aminotransferase
HV045_18185	COG0371	Dehydrogenase
HV045_18190	COG2879	small protein
HV045_18195	COG1966	Carbon starvation protein
HV045_18205	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_18210	COG3433	isochorismatase activity
HV045_18210	COG1535	isochorismatase
HV045_18215	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV045_18220	COG1169	isochorismate synthase
HV045_18225	COG4592	Periplasmic binding protein
HV045_18235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV045_18240	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV045_18245	COG1120	ATPase activity
HV045_18250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV045_18250	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV045_18255	COG3251	PFAM MbtH domain protein
HV045_18260	COG2382	esterase
HV045_18265	COG4771	TonB-dependent receptor
HV045_18275	COG1879	ABC-type sugar transport system periplasmic component
HV045_18285	COG1129	ABC transporter
HV045_18290	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_18295	COG2390	Transcriptional regulator
HV045_18300	COG3959	Transketolase, thiamine diphosphate binding domain
HV045_18305	COG3958	Transketolase
HV045_18315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV045_18345	COG3039	Transposase
HV045_18420	COG2501	S4 domain
HV045_18425	COG1988	membrane-bound metal-dependent
HV045_18435	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV045_18445	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV045_18450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV045_18460	COG2011	ABC-type metal ion transport system permease component
HV045_18470	COG1464	Belongs to the NlpA lipoprotein family
HV045_18480	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV045_18485	COG4181	ATPase activity
HV045_18490	COG2755	lipolytic protein G-D-S-L family
HV045_18495	COG0300	oxidoreductase activity
HV045_18500	COG3118	belongs to the thioredoxin family
HV045_18505	COG0390	transport system, permease component
HV045_18510	COG4619	ABC transporter
HV045_18515	COG0330	HflC and HflK could
HV045_18520	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV045_18540	COG4771	TonB-dependent receptor
HV045_18545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV045_18560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV045_18585	COG3778	Protein conserved in bacteria
HV045_18590	COG3299	homolog of phage Mu protein gp47
HV045_18620	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
HV045_18630	COG4386	tail sheath protein
HV045_18660	COG4397	Mu-like prophage major head subunit gpT
HV045_18680	COG4373	Mu-like prophage FluMu protein gp28
HV045_18740	COG5566	PFAM Mor transcription activator
HV045_18765	COG4396	Host-nuclease inhibitor protein Gam
HV045_18785	COG2842	Transposition protein
HV045_18790	COG2801	Transposase and inactivated derivatives
HV045_18815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV045_18830	COG3735	TraB family
HV045_18835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV045_18845	COG2223	nitrite transmembrane transporter activity
HV045_18850	COG4651	solute:proton antiporter activity
HV045_18850	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV045_18855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_18900	COG2832	Protein of unknown function (DUF454)
HV045_18905	COG3923	Primosomal replication protein n
HV045_18915	COG3264	Mechanosensitive ion channel
HV045_18915	COG1196	nuclear chromosome segregation
HV045_18920	COG1309	transcriptional regulator
HV045_18925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV045_18930	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV045_18945	COG0110	maltose O-acetyltransferase activity
HV045_18965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV045_18970	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV045_18975	COG2364	Membrane
HV045_18980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV045_19000	COG3695	enzyme binding
HV045_19005	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV045_19010	COG1946	Acyl-CoA thioesterase
HV045_19015	COG0004	ammonium transporteR
HV045_19020	COG0347	Belongs to the P(II) protein family
HV045_19025	COG1132	(ABC) transporter
HV045_19030	COG1132	(ABC) transporter
HV045_19035	COG1522	sequence-specific DNA binding
HV045_19050	COG4533	DNA binding
HV045_19060	COG0824	Thioesterase
HV045_19065	COG1555	photosystem II stabilization
HV045_19070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV045_19075	COG0776	regulation of translation
HV045_19080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV045_19100	COG0271	Belongs to the BolA IbaG family
HV045_19105	COG3056	Lipoprotein
HV045_19110	COG2223	nitrite transmembrane transporter activity
HV045_19115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV045_19120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV045_19125	COG1845	cytochrome c oxidase, subunit III
HV045_19130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV045_19155	COG2814	Major facilitator Superfamily
HV045_19190	COG0142	geranyltranstransferase activity
HV045_19200	COG0667	Aldo Keto reductase
HV045_19205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV045_19210	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV045_19225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV045_19225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV045_19235	COG4238	major outer membrane lipoprotein
HV045_19255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV045_19260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV045_19265	COG1862	Preprotein translocase
HV045_19275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV045_19285	COG0450	alkyl hydroperoxide reductase
HV045_19300	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV045_19310	COG1335	isochorismatase
HV045_19315	COG0583	DNA-binding transcription factor activity
HV045_19320	COG0366	Alpha amylase catalytic
HV045_19335	COG5002	protein histidine kinase activity
HV045_19345	COG0420	3'-5' exonuclease activity
HV045_19350	COG0419	ATPase involved in DNA repair
HV045_19355	COG2814	Major facilitator Superfamily
HV045_19360	COG1940	carbohydrate kinase activity
HV045_19375	COG4126	flavin adenine dinucleotide binding
HV045_19395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV045_19400	COG3706	GGDEF domain
HV045_19410	COG1785	Belongs to the alkaline phosphatase family
HV045_19425	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV045_19445	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV045_19450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV045_19455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV045_19460	COG3468	outer membrane autotransporter barrel domain protein
HV045_19465	COG0113	porphobilinogen synthase activity
HV045_19470	COG2175	clavaminate synthase activity
HV045_19475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV045_19480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HV045_19485	COG4521	taurine ABC transporter
HV045_19500	COG2271	Major facilitator Superfamily
HV045_19505	COG1840	ABC-type Fe3 transport system, periplasmic component
HV045_19515	COG3842	ATPase activity
HV045_19520	COG2040	homocysteine
HV045_19525	COG0833	amino acid
HV045_19530	COG2814	Major facilitator Superfamily
HV045_19565	COG1414	Transcriptional regulator
HV045_19600	COG3210	domain, Protein
HV045_19615	COG1609	Transcriptional regulator
HV045_19635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV045_19640	COG0693	protein deglycase activity
HV045_19645	COG0531	amino acid
HV045_19650	COG0174	glutamine synthetase
HV045_19655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV045_19660	COG1396	sequence-specific DNA binding
HV045_19660	COG1917	Cupin 2, conserved barrel domain protein
HV045_19665	COG1012	belongs to the aldehyde dehydrogenase family
HV045_19670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV045_19685	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HV045_19690	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV045_19695	COG1999	signal sequence binding
HV045_19700	COG1773	rubredoxin
HV045_19705	COG1271	oxidase subunit
HV045_19710	COG1294	oxidase, subunit
HV045_19720	COG0582	viral genome integration into host DNA
HV045_19725	COG3039	Transposase
HV045_19765	COG3344	reverse transcriptase
HV045_19775	COG2826	transposase and inactivated derivatives, IS30 family
HV045_19790	COG0840	transmembrane signaling receptor activity
HV045_19840	COG1294	oxidase, subunit
HV045_19865	COG3596	GTP binding
HV045_19875	COG2378	regulation of single-species biofilm formation
HV045_19885	COG2378	regulation of single-species biofilm formation
HV045_19905	COG2003	Belongs to the UPF0758 family
HV045_19935	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV045_19955	COG2826	transposase and inactivated derivatives, IS30 family
HV045_19985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV045_19995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV045_20020	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV045_20040	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HV045_20045	COG1191	sigma factor activity
HV045_20070	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV045_20095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV045_20100	COG1256	bacterial-type flagellum assembly
HV045_20100	COG4786	Flagellar basal body rod
HV045_20120	COG4786	Flagellar basal body rod
HV045_20125	COG4787	bacterial-type flagellum-dependent cell motility
HV045_20140	COG1558	bacterial-type flagellum-dependent cell motility
HV045_20175	COG3039	Transposase
HV045_20190	COG1987	bacterial-type flagellum assembly
HV045_20195	COG1684	flagellar biosynthetic protein fliR
HV045_20210	COG0791	NLP P60 protein
HV045_20215	COG3034	peptidoglycan biosynthetic process
HV045_20220	COG0121	glutamine amidotransferase
HV045_20230	COG1960	acyl-CoA dehydrogenase activity
HV045_20235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV045_20245	COG2200	EAL domain
HV045_20260	COG3539	Fimbrial protein
HV045_20265	COG3539	Fimbrial protein
HV045_20270	COG3121	Chaperone
HV045_20275	COG3188	usher protein
HV045_20285	COG3539	Fimbrial protein
HV045_20305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV045_20315	COG2226	methyltransferase
HV045_20325	COG1388	LysM domain
HV045_20325	COG0741	lytic transglycosylase activity
HV045_20330	COG2226	methyltransferase
HV045_20340	COG2814	Major facilitator Superfamily
HV045_20345	COG0583	DNA-binding transcription factor activity
HV045_20380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV045_20390	COG2011	ABC-type metal ion transport system permease component
HV045_20395	COG1464	Belongs to the NlpA lipoprotein family
HV045_20405	COG1720	tRNA m6t6A37 methyltransferase activity
HV045_20415	COG0791	NLP P60 protein
HV045_20420	COG3015	lipoprotein NlpE involved in copper resistance
HV045_20425	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV045_20440	COG4568	rho-dependent transcription termination
HV045_20450	COG0346	lactoylglutathione lyase activity
HV045_20490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV045_20495	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV045_20510	COG0575	Belongs to the CDS family
HV045_20520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV045_20565	COG3835	regulator
HV045_20590	COG2860	membrane
HV045_20615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV045_20620	COG1120	ATPase activity
HV045_20625	COG4774	siderophore transport
HV045_20630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV045_20635	COG1643	Atp-dependent helicase
HV045_20640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV045_20660	COG0617	tRNA 3'-terminal CCA addition
HV045_20665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV045_20685	COG0726	polysaccharide deacetylase
HV045_20690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_20695	COG0842	Transport permease protein
HV045_20700	COG1131	(ABC) transporter
HV045_20705	COG0288	reversible hydration of carbon dioxide
HV045_20710	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV045_20715	COG4993	Dehydrogenase
HV045_20750	COG3064	Membrane
HV045_20765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV045_20770	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV045_20775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV045_20790	COG2211	Major facilitator Superfamily
HV045_20795	COG3940	Belongs to the glycosyl hydrolase 43 family
HV045_20800	COG3725	Membrane protein required for beta-lactamase induction
HV045_20815	COG4969	Belongs to the N-Me-Phe pilin family
HV045_20820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV045_20825	COG1459	type II secretion system
HV045_20835	COG0237	dephospho-CoA kinase activity
HV045_20850	COG0494	nUDIX hydrolase
HV045_20870	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV045_20875	COG0849	cell division
HV045_20885	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV045_20900	COG0772	Belongs to the SEDS family
HV045_20905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV045_20915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV045_20920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV045_20925	COG0768	penicillin binding
HV045_20955	COG0028	Belongs to the TPP enzyme family
HV045_20990	COG2814	Major facilitator Superfamily
HV045_21010	COG1178	ABC-type Fe3 transport system permease component
HV045_21020	COG0586	Pfam SNARE associated Golgi protein
HV045_21040	COG0235	Class ii aldolase
HV045_21050	COG0417	DNA replication proofreading
HV045_21060	COG0564	pseudouridine synthase activity
HV045_21120	COG2271	Major facilitator Superfamily
HV045_21130	COG0644	oxidoreductase
HV045_21180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV045_21185	COG0505	Belongs to the CarA family
HV045_21195	COG1609	Transcriptional regulator
HV045_21210	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_21210	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_21215	COG3715	PTS system
HV045_21220	COG3716	PTS system mannose fructose sorbose family IID component
HV045_21230	COG2140	Oxalate decarboxylase
HV045_21245	COG1047	Peptidyl-prolyl cis-trans
HV045_21260	COG0196	riboflavin kinase activity
HV045_21285	COG0583	DNA-binding transcription factor activity
HV045_21300	COG0443	Heat shock 70 kDa protein
HV045_21305	COG1584	GPR1 FUN34 yaaH family protein
HV045_21315	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV045_21325	COG1115	amino acid carrier protein
HV045_21335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV045_21345	COG0460	homoserine dehydrogenase
HV045_21345	COG0527	aspartate kinase activity
HV045_21355	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV045_21365	COG0745	RESPONSE REGULATOR receiver
HV045_21370	COG4452	Inner membrane protein CreD
HV045_21375	COG2205	protein histidine kinase activity
HV045_21380	COG0745	RESPONSE REGULATOR receiver
HV045_21385	COG3045	CreA protein
HV045_21390	COG2207	Transcriptional regulator
HV045_21390	COG3708	Transcriptional regulator
HV045_21410	COG0741	lytic transglycosylase activity
HV045_21415	COG0488	(ABC) transporter
HV045_21430	COG0560	Phosphoserine phosphatase
HV045_21435	COG3726	membrane protein affecting hemolysin expression
HV045_21465	COG1328	CTP reductase activity
HV045_21470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV045_21475	COG0084	hydrolase, TatD family'
HV045_21480	COG4667	esterase of the alpha-beta hydrolase superfamily
HV045_21485	COG5487	UPF0391 membrane protein
HV045_21490	COG2823	Periplasmic or secreted lipoprotein
HV045_21500	COG1011	Hydrolase
HV045_21505	COG0456	acetyltransferase
HV045_21510	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV045_21540	COG3706	GGDEF domain
HV045_21545	COG4114	ferric iron reductase
HV045_21550	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV045_21555	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV045_21560	COG2197	response regulator
HV045_21565	COG2197	response regulator
HV045_21570	COG2966	Psort location CytoplasmicMembrane, score
HV045_21585	COG1484	DNA-dependent DNA replication
HV045_21605	COG1063	alcohol dehydrogenase
HV045_21610	COG1802	Transcriptional regulator
HV045_21615	COG2271	Major facilitator Superfamily
HV045_21625	COG0840	transmembrane signaling receptor activity
HV045_21630	COG1966	Carbon starvation protein
HV045_21635	COG2879	small protein
HV045_21640	COG0523	cobalamin synthesis protein
HV045_21670	COG1715	Restriction endonuclease
HV045_21705	COG1566	PFAM secretion protein HlyD family protein
HV045_21715	COG5457	Domain of unknown function (DUF1127)
HV045_21720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV045_21725	COG5464	transposase or invertase
HV045_21725	COG5464	transposase or invertase
HV045_21730	COG1917	Cupin 2, conserved barrel domain protein
HV045_21730	COG2207	Transcriptional regulator
HV045_21745	COG0626	cystathionine gamma-synthase activity
HV045_21750	COG1301	dicarboxylic acid transport
HV045_21755	COG0583	DNA-binding transcription factor activity
HV045_21760	COG2733	membrane
HV045_21765	COG0477	Major facilitator Superfamily
HV045_21775	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV045_21785	COG2186	Transcriptional regulator
HV045_21790	COG0246	Mannitol dehydrogenase
HV045_21800	COG2610	gluconate transmembrane transporter activity
HV045_21805	COG1556	Lactate utilization protein
HV045_21810	COG1139	Iron-sulfur cluster binding protein
HV045_21815	COG0247	lactate metabolic process
HV045_21820	COG1620	l-lactate permease
HV045_21905	COG1196	nuclear chromosome segregation
HV045_21910	COG0582	viral genome integration into host DNA
HV045_21920	COG1064	alcohol dehydrogenase
HV045_21925	COG3265	gluconokinase activity
HV045_21930	COG1063	alcohol dehydrogenase
HV045_21935	COG1028	Short-chain dehydrogenase reductase Sdr
HV045_21940	COG2610	gluconate transmembrane transporter activity
HV045_21945	COG1609	Transcriptional regulator
HV045_21950	COG0433	COG0433 Predicted ATPase
HV045_21955	COG0795	lipopolysaccharide-transporting ATPase activity
HV045_21960	COG0795	lipopolysaccharide-transporting ATPase activity
HV045_21970	COG2927	DNA polymerase III (CHI subunit)
HV045_21975	COG0525	valine-tRNA ligase activity
HV045_22010	COG2731	YhcH YjgK YiaL family protein
HV045_22045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV045_22050	COG1288	antiporter activity
HV045_22055	COG1438	arginine binding
HV045_22105	COG1263	PTS System
HV045_22105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV045_22110	COG0366	Alpha amylase catalytic
HV045_22130	COG3501	Rhs element vgr protein
HV045_22135	COG2026	Addiction module toxin, RelE StbE family
HV045_22215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_22215	COG3711	transcriptional antiterminator
HV045_22230	COG3964	amidohydrolase
HV045_22265	COG0312	modulator of DNA gyrase
HV045_22275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV045_22285	COG1486	melibiose metabolic process
HV045_22290	COG0517	IMP dehydrogenase activity
HV045_22290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV045_22295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV045_22305	COG0840	transmembrane signaling receptor activity
HV045_22310	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_22315	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_22320	COG1129	ABC transporter
HV045_22325	COG1879	ABC-type sugar transport system periplasmic component
HV045_22335	COG3391	amine dehydrogenase activity
HV045_22340	COG4771	TonB-dependent receptor
HV045_22345	COG2105	PFAM AIG2 family protein
HV045_22350	COG2911	Protein conserved in bacteria
HV045_22355	COG0729	surface antigen
HV045_22365	COG1253	flavin adenine dinucleotide binding
HV045_22375	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV045_22380	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV045_22405	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HV045_22515	COG2369	cell adhesion
HV045_22525	COG4373	Mu-like prophage FluMu protein gp28
HV045_22605	COG3409	Peptidoglycan-binding domain 1 protein
HV045_22605	COG3267	Type II secretory pathway component ExeA
HV045_22645	COG4382	Mu-like prophage protein Gp16
HV045_22660	COG1733	regulation of RNA biosynthetic process
HV045_22665	COG0702	epimerase
HV045_22675	COG0697	spore germination
HV045_22680	COG0840	transmembrane signaling receptor activity
HV045_22690	COG1113	amino acid transport
HV045_22695	COG0545	Peptidyl-prolyl cis-trans isomerase
HV045_22700	COG3061	Opacity-associated protein A
HV045_22715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV045_22730	COG0730	response to heat
HV045_22780	COG1073	alpha beta
HV045_22785	COG3650	response to hydrogen peroxide
HV045_22795	COG1960	acyl-CoA dehydrogenase activity
HV045_22800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV045_22805	COG0557	exoribonuclease II activity
HV045_22820	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV045_22825	COG0330	HflC and HflK could
HV045_22830	COG0330	HflC and HflK could
HV045_22835	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV045_22840	COG1923	regulation of RNA biosynthetic process
HV045_22855	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV045_22860	COG0802	atpase or kinase
HV045_22865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV045_22865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV045_22870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV045_22905	COG3264	Mechanosensitive ion channel
HV045_22905	COG1511	domain protein
HV045_22930	COG1053	succinate dehydrogenase
HV045_22935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV045_22990	COG1509	lysine 2,3-aminomutase activity
HV045_23015	COG0531	amino acid
HV045_23020	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV045_23025	COG1027	Aspartate ammonia-lyase
HV045_23030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV045_23045	COG1309	transcriptional regulator
HV045_23060	COG3039	Transposase
HV045_23080	COG4974	Belongs to the 'phage' integrase family
HV045_23125	COG3596	GTP binding
HV045_23195	COG3290	protein histidine kinase activity
HV045_23200	COG4565	transcriptional regulatory protein
HV045_23210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV045_23215	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_23215	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV045_23220	COG3647	Membrane
HV045_23230	COG2211	Major facilitator Superfamily
HV045_23235	COG1486	melibiose metabolic process
HV045_23240	COG2169	Transcriptional regulator
HV045_23245	COG1982	Orn Lys Arg decarboxylase major
HV045_23250	COG2207	Transcriptional regulator
HV045_23255	COG0531	amino acid
HV045_23300	COG2824	Alkylphosphonate utilization operon protein PhnA
HV045_23305	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV045_23310	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV045_23315	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV045_23320	COG3639	organic phosphonate transmembrane transporter activity
HV045_23325	COG2188	Transcriptional regulator
HV045_23330	COG3624	Phosphonate C-P lyase system protein PhnG
HV045_23335	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV045_23340	COG3626	phosphonate metabolism
HV045_23345	COG3627	carbon phosphorus lyase activity
HV045_23350	COG4107	phosphonate C-P lyase system protein PhnK
HV045_23355	COG4778	phosphonate C-P lyase system protein PhnL
HV045_23360	COG3454	Phosphonate metabolism
HV045_23365	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV045_23370	COG0456	acetyltransferase
HV045_23375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV045_23395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_23440	COG3162	membrane
HV045_23450	COG1346	cytolysis
HV045_23455	COG1380	Effector of murein hydrolase LrgA
HV045_23460	COG0583	DNA-binding transcription factor activity
HV045_23465	COG0025	NhaP-type Na H and K H
HV045_23470	COG2252	PERMEase
HV045_23475	COG0789	Transcriptional regulator
HV045_23490	COG3039	Transposase
HV045_23500	COG0629	single-stranded DNA binding
HV045_23505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV045_23510	COG2315	Protein conserved in bacteria
HV045_23515	COG3700	Belongs to the class B bacterial acid phosphatase family
HV045_23520	COG1448	Aminotransferase
HV045_23530	COG0305	Participates in initiation and elongation during chromosome replication
HV045_23545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV045_23555	COG0735	belongs to the Fur family
HV045_23560	COG3237	CsbD-like
HV045_23565	COG0534	Mate efflux family protein
HV045_23575	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV045_23610	COG2182	Extracellular solute-binding protein
HV045_23625	COG3223	Belongs to the PsiE family
HV045_23630	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV045_23635	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV045_23660	COG0527	aspartate kinase activity
HV045_23675	COG1187	pseudouridine synthase activity
HV045_23680	COG4977	sequence-specific DNA binding
HV045_23700	COG0646	methionine synthase
HV045_23700	COG1410	methionine synthase
HV045_23720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV045_23755	COG0151	Belongs to the GarS family
HV045_23765	COG4191	Histidine kinase
HV045_23820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV045_23825	COG2104	thiamine diphosphate biosynthetic process
HV045_23840	COG1278	Cold shock
HV045_23850	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV045_23885	COG0250	Participates in transcription elongation, termination and antitermination
HV045_23930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV045_23990	COG0583	DNA-binding transcription factor activity
HV045_23995	COG3979	chitinase
HV045_24030	COG2207	Transcriptional regulator
HV045_24035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_24040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV045_24045	COG1882	Formate acetyltransferase
HV045_24050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_24055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_24060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_24060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_24060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV045_24070	COG0371	Dehydrogenase
HV045_24080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV045_24085	COG0583	DNA-binding transcription factor activity
HV045_24095	COG0737	Belongs to the 5'-nucleotidase family
HV045_24105	COG0527	aspartate kinase activity
HV045_24105	COG0460	homoserine dehydrogenase
HV045_24110	COG0626	cystathionine gamma-synthase activity
HV045_24120	COG2211	Major facilitator Superfamily
HV045_24135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV045_24140	COG1609	Transcriptional regulator
HV045_24145	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV045_24160	COG1575	Belongs to the MenA family. Type 1 subfamily
HV045_24175	COG0582	viral genome integration into host DNA
HV045_24195	COG3074	FtsZ-dependent cytokinesis
HV045_24200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV045_24210	COG1494	fructose-1,6-bisphosphatase
HV045_24220	COG3152	Membrane
HV045_24245	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV045_24260	COG3678	ATP-independent chaperone mediated protein folding
HV045_24265	COG0745	RESPONSE REGULATOR receiver
HV045_24270	COG2205	protein histidine kinase activity
HV045_24280	COG3039	Transposase
HV045_24290	COG1082	Xylose isomerase domain protein TIM barrel
HV045_24295	COG2188	Transcriptional regulator
HV045_24300	COG2258	MOSC domain
HV045_24305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV045_24350	COG1454	alcohol dehydrogenase
HV045_24365	COG3039	Transposase
HV045_24375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV045_24385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_24390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_24390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV045_24395	COG1363	Peptidase, m42
HV045_24400	COG3711	transcriptional antiterminator
HV045_24400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV045_24420	COG0437	4 iron, 4 sulfur cluster binding
HV045_24425	COG2864	formate dehydrogenase
HV045_24440	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV045_24445	COG0657	acetylesterase activity
HV045_24450	COG3609	addiction module antidote protein, CC2985 family
HV045_24460	COG0456	acetyltransferase
HV045_24465	COG1490	D-aminoacyl-tRNA deacylase activity
HV045_24490	COG1349	DNA-binding transcription factor activity
HV045_24495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_24505	COG3684	Belongs to the aldolase LacD family
HV045_24515	COG2017	converts alpha-aldose to the beta-anomer
HV045_24520	COG1501	Belongs to the glycosyl hydrolase 31 family
HV045_24550	COG3852	Histidine kinase
HV045_24555	COG2204	response regulator
HV045_24565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV045_24590	COG0204	Acyl-transferase
HV045_24605	COG3084	Protein conserved in bacteria
HV045_24610	COG0746	molybdenum cofactor guanylyltransferase activity
HV045_24615	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV045_24655	COG1739	Uncharacterized protein family UPF0029
HV045_24675	COG1609	Transcriptional regulator
HV045_24680	COG1940	carbohydrate kinase activity
HV045_24690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV045_24705	COG0805	protein transport
HV045_24750	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV045_24755	COG0583	DNA-binding transcription factor activity
HV045_24760	COG0697	spore germination
HV045_24765	COG0561	phosphatase activity
HV045_24770	COG2267	carboxylic ester hydrolase activity
HV045_24775	COG1280	lysine exporter protein (LysE YggA)
HV045_24780	COG1280	lysine exporter protein (LysE YggA)
HV045_24815	COG1011	Hydrolase
HV045_24860	COG2959	enzyme of heme biosynthesis
HV045_24865	COG3071	HemY protein
HV045_24910	COG2244	polysaccharide biosynthetic process
HV045_24915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV045_24920	COG0456	acetyltransferase
HV045_24925	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV045_24930	COG1088	dTDP-glucose 4,6-dehydratase activity
HV045_24935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV045_24950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV045_24955	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV045_24965	COG3118	belongs to the thioredoxin family
HV045_24985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV045_25005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV045_25015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV045_25020	COG3978	acetolactate synthase activity
HV045_25040	COG3085	chromosome segregation
HV045_25080	COG2186	Transcriptional regulator
HV045_25085	COG0477	Major facilitator Superfamily
HV045_25090	COG1609	Transcriptional regulator
HV045_25095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV045_25100	COG1879	ABC-type sugar transport system periplasmic component
HV045_25105	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV045_25115	COG1869	D-ribose catabolic process
HV045_25140	COG1522	sequence-specific DNA binding
HV045_25145	COG0716	FMN binding
HV045_25160	COG3312	ion transport
HV045_25185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV045_25195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV045_25200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV045_25215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV045_25220	COG0573	inorganic phosphate transmembrane transporter activity
HV045_25225	COG0581	inorganic phosphate transmembrane transporter activity
HV045_25235	COG0704	Plays a role in the regulation of phosphate uptake
HV045_25240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV045_25245	COG2252	PERMEase
HV045_25250	COG0431	NADPH-dependent FMN reductase
HV045_25255	COG2091	lysine biosynthetic process via aminoadipic acid
HV045_25290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV045_25395	COG0058	SHG alpha-glucan phosphorylase activity
HV045_25400	COG0033	Phosphoglucomutase
HV045_25460	COG3039	Transposase
HV045_25470	COG1528	Iron-storage protein
HV045_25480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV045_25520	COG0789	Transcriptional regulator
HV045_25535	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV045_25545	COG0589	response to stress
HV045_25565	COG4644	lycopene metabolic process
HV045_25605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV045_25650	COG0625	glutathione transferase activity
HV045_25655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV045_25670	COG0583	DNA-binding transcription factor activity
HV045_25680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HV045_25695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HV045_25715	COG1846	Transcriptional regulator
HV045_25720	COG0583	DNA-binding transcription factor activity
HV045_25730	COG2948	multi-organism process
HV045_25790	COG0789	Transcriptional regulator
HV045_25800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HV045_25805	COG1522	sequence-specific DNA binding
HV045_25830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV045_25835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV045_25850	COG3423	Transcriptional regulator
HV045_26010	COG2974	May be involved in recombination
HV045_26065	COG1802	Transcriptional regulator
HV045_26120	COG2801	Transposase and inactivated derivatives
HV045_26130	COG2801	Transposase and inactivated derivatives
HV045_26140	COG2801	Transposase and inactivated derivatives
HV045_26165	COG2826	transposase and inactivated derivatives, IS30 family
HV045_26220	COG1127	ABC transporter
HV045_26225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV045_26310	COG0210	DNA helicase
HV045_26645	COG1199	ATP-dependent helicase activity
HV045_26785	COG5654	RES domain protein
HV045_26790	COG5642	Protein of unknown function (DUF2384)
HV045_26840	COG1192	Involved in chromosome partitioning
HV045_26890	COG4372	Transposase
HV045_26895	COG3436	PFAM IS66 Orf2 family protein
HV045_26920	COG4372	Transposase
HV045_26925	COG3436	PFAM IS66 Orf2 family protein
HV045_27100	COG1215	transferase activity, transferring glycosyl groups