locus-tag	class	description
HV243_00010	COG0592	DNA-directed DNA polymerase activity
HV243_00025	COG0561	phosphatase activity
HV243_00035	COG0823	Involved in the tonB-independent uptake of proteins
HV243_00040	COG5645	(Lipo)protein
HV243_00065	COG2188	Transcriptional regulator
HV243_00080	COG2207	Transcriptional regulator
HV243_00085	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV243_00090	COG3119	arylsulfatase activity
HV243_00095	COG2149	membrane
HV243_00105	COG0641	radical SAM
HV243_00115	COG2610	gluconate transmembrane transporter activity
HV243_00120	COG0583	DNA-binding transcription factor activity
HV243_00130	COG2814	Major facilitator Superfamily
HV243_00150	COG0028	Belongs to the TPP enzyme family
HV243_00155	COG0440	acetolactate synthase activity
HV243_00160	COG1349	DNA-binding transcription factor activity
HV243_00170	COG0738	Major facilitator superfamily
HV243_00180	COG2197	response regulator
HV243_00210	COG2723	6-phospho-beta-galactosidase activity
HV243_00225	COG1464	Belongs to the NlpA lipoprotein family
HV243_00230	COG0697	spore germination
HV243_00245	COG0583	DNA-binding transcription factor activity
HV243_00255	COG3539	Fimbrial protein
HV243_00275	COG2197	response regulator
HV243_00295	COG2771	luxR family
HV243_00335	COG2003	Belongs to the UPF0758 family
HV243_00405	COG2814	Major facilitator Superfamily
HV243_00420	COG3111	PFAM Bacterial OB fold (BOF) protein
HV243_00425	COG0464	growth
HV243_00430	COG1404	Belongs to the peptidase S8 family
HV243_00435	COG0582	viral genome integration into host DNA
HV243_00445	COG2211	Major facilitator Superfamily
HV243_00450	COG1501	Belongs to the glycosyl hydrolase 31 family
HV243_00455	COG3711	transcriptional antiterminator
HV243_00460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_00460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_00460	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_00465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_00470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_00470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_00480	COG0191	fructose-bisphosphate aldolase activity
HV243_00490	COG2982	Protein involved in outer membrane biogenesis
HV243_00495	COG2233	PERMEase
HV243_00500	COG0786	glutamate:sodium symporter activity
HV243_00505	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HV243_00510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV243_00515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV243_00535	COG2860	membrane
HV243_00540	COG1561	YicC-like family, N-terminal region
HV243_00565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HV243_00580	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HV243_00595	COG1519	Transferase
HV243_00600	COG0438	transferase activity, transferring glycosyl groups
HV243_00605	COG0515	serine threonine protein kinase
HV243_00610	COG1442	glycosyl transferase family 8
HV243_00615	COG1442	glycosyl transferase family 8
HV243_00625	COG0859	PFAM glycosyl transferase family 9
HV243_00630	COG1216	Glycosyl transferase, family 2
HV243_00630	COG1442	glycosyl transferase family 8
HV243_00635	COG3307	-O-antigen
HV243_00645	COG0859	PFAM glycosyl transferase family 9
HV243_00655	COG0156	8-amino-7-oxononanoate synthase activity
HV243_00665	COG1216	Glycosyl transferase, family 2
HV243_00670	COG2861	carbohydrate metabolic process
HV243_00675	COG4942	peptidase
HV243_00685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV243_00690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HV243_00710	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HV243_00715	COG2271	Major facilitator Superfamily
HV243_00725	COG2186	Transcriptional regulator
HV243_00755	COG3722	fumarate hydratase activity
HV243_00765	COG2213	PTS system mannitol-specific
HV243_00765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_00775	COG1566	PFAM secretion protein HlyD family protein
HV243_00780	COG0625	glutathione transferase activity
HV243_00790	COG3276	selenocysteine insertion sequence binding
HV243_00795	COG1454	alcohol dehydrogenase
HV243_00800	COG1012	belongs to the aldehyde dehydrogenase family
HV243_00810	COG1566	PFAM secretion protein HlyD family protein
HV243_00815	COG0583	DNA-binding transcription factor activity
HV243_00820	COG3713	MltA-interacting MipA family protein
HV243_00825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_00830	COG3977	Valine--pyruvate aminotransferase
HV243_00835	COG0366	Alpha amylase catalytic
HV243_00840	COG2992	FlgJ-related protein
HV243_00845	COG1609	Transcriptional regulator
HV243_00845	COG2207	Transcriptional regulator
HV243_00850	COG4214	carbohydrate transport
HV243_00860	COG4213	ABC transporter substrate-binding protein
HV243_00870	COG1070	Carbohydrate kinase
HV243_00875	COG4682	membrane
HV243_00880	COG4682	membrane
HV243_00885	COG3274	enterobacterial common antigen metabolic process
HV243_00910	COG1278	Cold shock
HV243_00915	COG2944	sequence-specific DNA binding
HV243_00930	COG2814	Major facilitator Superfamily
HV243_00935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_00945	COG1609	Transcriptional regulator
HV243_00950	COG2885	chlorophyll binding
HV243_00955	COG0243	molybdopterin cofactor binding
HV243_00960	COG0456	acetyltransferase
HV243_00965	COG2818	Glycosylase
HV243_00970	COG5571	outer membrane autotransporter
HV243_00975	COG2223	nitrite transmembrane transporter activity
HV243_00995	COG0747	negative chemotaxis
HV243_01000	COG0601	transmembrane transport
HV243_01005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV243_01010	COG0444	Belongs to the ABC transporter superfamily
HV243_01015	COG4608	Belongs to the ABC transporter superfamily
HV243_01020	COG2204	response regulator
HV243_01025	COG0814	amino acid
HV243_01030	COG0626	cystathionine gamma-synthase activity
HV243_01040	COG2199	diguanylate cyclase activity
HV243_01040	COG2200	EAL domain
HV243_01055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_01060	COG2200	EAL domain
HV243_01065	COG2982	Protein involved in outer membrane biogenesis
HV243_01070	COG0477	Major facilitator Superfamily
HV243_01075	COG1295	ribonuclease BN
HV243_01080	COG0583	DNA-binding transcription factor activity
HV243_01085	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_01090	COG2197	response regulator
HV243_01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV243_01115	COG1858	cytochrome C peroxidase
HV243_01125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV243_01130	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HV243_01135	COG0339	signal peptide processing
HV243_01150	COG1959	2 iron, 2 sulfur cluster binding
HV243_01160	COG0589	response to stress
HV243_01170	COG0306	phosphate transporter
HV243_01175	COG2081	HI0933 family
HV243_01180	COG2239	Acts as a magnesium transporter
HV243_01185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_01190	COG1129	ABC transporter
HV243_01190	COG0842	Transport permease protein
HV243_01195	COG0842	Transport permease protein
HV243_01210	COG3479	Phenolic acid decarboxylase
HV243_01215	COG2091	lysine biosynthetic process via aminoadipic acid
HV243_01220	COG0628	permease
HV243_01225	COG0477	Major facilitator Superfamily
HV243_01235	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HV243_01250	COG3714	YhhN family
HV243_01260	COG3776	membrane
HV243_01265	COG0742	ribosomal rna small subunit methyltransferase
HV243_01270	COG0552	protein localization to endoplasmic reticulum
HV243_01275	COG2884	Cell division ATP-binding protein ftsE
HV243_01280	COG2177	Part of the ABC transporter FtsEX involved in
HV243_01300	COG0683	leucine binding
HV243_01310	COG4177	L-phenylalanine transmembrane transporter activity
HV243_01315	COG0411	ABC transporter
HV243_01320	COG0410	ABC transporter
HV243_01350	COG0584	glycerophosphoryl diester phosphodiesterase
HV243_01360	COG0405	Gamma-glutamyltransferase
HV243_01370	COG1247	-acetyltransferase
HV243_01375	COG0673	inositol 2-dehydrogenase activity
HV243_01380	COG1741	Belongs to the pirin family
HV243_01385	COG1609	Transcriptional regulator
HV243_01390	COG3265	gluconokinase activity
HV243_01395	COG2610	gluconate transmembrane transporter activity
HV243_01405	COG2095	MarC family integral membrane protein
HV243_01410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV243_01435	COG0058	SHG alpha-glucan phosphorylase activity
HV243_01440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV243_01455	COG1349	DNA-binding transcription factor activity
HV243_01465	COG0058	SHG alpha-glucan phosphorylase activity
HV243_01470	COG1640	4-alpha-glucanotransferase
HV243_01475	COG2610	gluconate transmembrane transporter activity
HV243_01485	COG1040	competence protein
HV243_01495	COG5464	transposase or invertase
HV243_01510	COG1918	ferrous iron import across plasma membrane
HV243_01515	COG2183	response to ionizing radiation
HV243_01520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV243_01525	COG0745	RESPONSE REGULATOR receiver
HV243_01540	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HV243_01550	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HV243_01555	COG1011	Hydrolase
HV243_01565	COG0494	nUDIX hydrolase
HV243_01570	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HV243_01575	COG4972	Pilus assembly protein
HV243_01595	COG4796	Type ii and iii secretion system protein
HV243_01610	COG3266	domain, Protein
HV243_01615	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HV243_01620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HV243_01630	COG0180	Tryptophanyl-tRNA synthetase
HV243_01650	COG2146	nitrite reductase [NAD(P)H] activity
HV243_01655	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HV243_01680	COG0512	Glutamine amidotransferase of anthranilate synthase
HV243_01685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HV243_01690	COG1289	transmembrane transporter activity
HV243_01700	COG1765	OsmC-like protein
HV243_01705	COG3954	Phosphoribulokinase
HV243_01715	COG0429	hydrolase of the alpha beta-hydrolase fold
HV243_01720	COG0488	(ABC) transporter
HV243_01735	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HV243_01740	COG1047	Peptidyl-prolyl cis-trans
HV243_01750	COG0545	Peptidyl-prolyl cis-trans isomerase
HV243_01755	COG2964	Protein conserved in bacteria
HV243_01815	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HV243_01820	COG3156	type II secretion system protein K
HV243_01825	COG4795	General secretion pathway protein
HV243_01830	COG2165	general secretion pathway protein
HV243_01835	COG2165	general secretion pathway protein
HV243_01840	COG2165	general secretion pathway protein
HV243_01845	COG1459	type II secretion system
HV243_01850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV243_01855	COG1450	Type ii and iii secretion system protein
HV243_01875	COG0051	transcription antitermination factor activity, RNA binding
HV243_01885	COG0088	Forms part of the polypeptide exit tunnel
HV243_01900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HV243_01975	COG0200	Binds to the 23S rRNA
HV243_01980	COG0201	protein transport
HV243_01995	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HV243_02020	COG0789	Transcriptional regulator
HV243_02025	COG3036	rescue of stalled ribosome
HV243_02035	COG0569	domain protein
HV243_02055	COG0758	DNA mediated transformation
HV243_02065	COG0551	DNA topoisomerase type I activity
HV243_02085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV243_02125	COG1126	abc transporter atp-binding protein
HV243_02130	COG0765	amino acid transport
HV243_02135	COG4597	amino acid ABC transporter
HV243_02140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV243_02150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV243_02155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_02160	COG1309	transcriptional regulator
HV243_02170	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HV243_02195	COG4145	pantothenate transmembrane transporter activity
HV243_02200	COG3924	membrane
HV243_02205	COG0439	Biotin carboxylase
HV243_02210	COG0511	ligase activity, forming carbon-carbon bonds
HV243_02225	COG0604	alcohol dehydrogenase
HV243_02230	COG2200	EAL domain
HV243_02230	COG2199	diguanylate cyclase activity
HV243_02235	COG1077	Cell shape determining protein MreB Mrl
HV243_02240	COG1792	Involved in formation and maintenance of cell shape
HV243_02245	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HV243_02255	COG1530	ribonuclease E activity
HV243_02260	COG3164	Protein of unknown function
HV243_02265	COG0312	modulator of DNA gyrase
HV243_02270	COG0583	DNA-binding transcription factor activity
HV243_02290	COG2732	(Barnase) inhibitor
HV243_02310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV243_02315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HV243_02320	COG3105	Protein conserved in bacteria
HV243_02325	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HV243_02340	COG0625	glutathione transferase activity
HV243_02345	COG2969	positive regulation of protein catabolic process
HV243_02355	COG3069	C4-dicarboxylate transmembrane transporter activity
HV243_02385	COG2731	YhcH YjgK YiaL family protein
HV243_02390	COG0402	S-adenosylhomocysteine deaminase activity
HV243_02395	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HV243_02400	COG0493	'glutamate synthase
HV243_02405	COG0069	glutamate synthase activity
HV243_02405	COG0070	glutamate synthase
HV243_02405	COG0067	glutamate synthase
HV243_02410	COG1242	4 iron, 4 sulfur cluster binding
HV243_02415	COG0784	Response regulator, receiver
HV243_02415	COG2198	Histidine kinase
HV243_02415	COG5002	protein histidine kinase activity
HV243_02420	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HV243_02430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_02445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV243_02455	COG1137	ATPase activity
HV243_02460	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HV243_02465	COG3117	lipopolysaccharide transmembrane transporter activity
HV243_02470	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HV243_02475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV243_02475	COG0517	IMP dehydrogenase activity
HV243_02480	COG0530	calcium, potassium:sodium antiporter activity
HV243_02485	COG1127	ABC transporter
HV243_02490	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HV243_02495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV243_02500	COG2854	intermembrane phospholipid transfer
HV243_02505	COG3113	response to antibiotic
HV243_02510	COG5007	Belongs to the BolA IbaG family
HV243_02520	COG3423	Transcriptional regulator
HV243_02525	COG0142	geranyltranstransferase activity
HV243_02530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HV243_02535	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HV243_02540	COG0697	spore germination
HV243_02550	COG2027	D-alanyl-D-alanine carboxypeptidase
HV243_02560	COG1534	Rna-binding protein
HV243_02570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HV243_02575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HV243_02585	COG3069	C4-dicarboxylate transmembrane transporter activity
HV243_02590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV243_02595	COG0583	DNA-binding transcription factor activity
HV243_02600	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HV243_02625	COG0195	Participates in both transcription termination and antitermination
HV243_02635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HV243_02665	COG0513	Belongs to the DEAD box helicase family
HV243_02670	COG0814	amino acid
HV243_02675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV243_02680	COG0826	peptidase U32
HV243_02685	COG0826	peptidase U32
HV243_02690	COG3154	lipid carrier protein
HV243_02695	COG3153	acetyltransferase
HV243_02710	COG0702	epimerase
HV243_02715	COG2823	Periplasmic or secreted lipoprotein
HV243_02730	COG3107	peptidoglycan biosynthetic process
HV243_02735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HV243_02750	COG1063	alcohol dehydrogenase
HV243_02755	COG3775	system Galactitol-specific IIC component
HV243_02760	COG3414	Phosphotransferase system galactitol-specific IIB component
HV243_02765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_02780	COG2721	sulfolactate sulfo-lyase activity
HV243_02785	COG2271	Major facilitator Superfamily
HV243_02795	COG2084	Dehydrogenase
HV243_02800	COG1929	Belongs to the glycerate kinase type-1 family
HV243_02810	COG0583	DNA-binding transcription factor activity
HV243_02830	COG1882	Formate acetyltransferase
HV243_02835	COG0251	oxidation-reduction process
HV243_02840	COG1760	l-serine dehydratase
HV243_02845	COG0814	amino acid
HV243_02860	COG1741	Belongs to the pirin family
HV243_02865	COG0583	DNA-binding transcription factor activity
HV243_02870	COG3152	Membrane
HV243_02875	COG0435	Glutathione S-transferase
HV243_02880	COG2259	Doxx family
HV243_02890	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HV243_02895	COG4575	ribosome binding
HV243_02900	COG1422	Protein of unknown function (DUF1090)
HV243_02910	COG0586	Pfam SNARE associated Golgi protein
HV243_02915	COG2186	Transcriptional regulator
HV243_02920	COG2271	Major facilitator Superfamily
HV243_02930	COG2721	sulfolactate sulfo-lyase activity
HV243_02950	COG0673	inositol 2-dehydrogenase activity
HV243_02955	COG1451	nucleotide metabolic process
HV243_02965	COG0446	pyridine nucleotide-disulphide oxidoreductase
HV243_02965	COG1902	pentaerythritol trinitrate reductase activity
HV243_02980	COG1609	Transcriptional regulator
HV243_02990	COG1175	transmembrane transport
HV243_02995	COG0395	ABC-type sugar transport system, permease component
HV243_03000	COG0366	Alpha amylase catalytic
HV243_03005	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HV243_03010	COG0531	amino acid
HV243_03015	COG2731	YhcH YjgK YiaL family protein
HV243_03020	COG3250	beta-galactosidase activity
HV243_03025	COG1609	Transcriptional regulator
HV243_03030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HV243_03040	COG0840	transmembrane signaling receptor activity
HV243_03045	COG1695	Transcriptional regulator
HV243_03050	COG2375	cellular response to nickel ion
HV243_03060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV243_03140	COG0358	DNA primase activity
HV243_03145	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HV243_03150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HV243_03155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV243_03165	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HV243_03170	COG0804	urea catabolic process
HV243_03195	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_03200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_03215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV243_03230	COG4991	sh3 domain protein
HV243_03235	COG3025	triphosphatase activity
HV243_03290	COG3384	dioxygenase
HV243_03295	COG0754	glutathionylspermidine amidase activity
HV243_03310	COG0494	nUDIX hydrolase
HV243_03315	COG3151	Protein conserved in bacteria
HV243_03320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HV243_03325	COG3150	esterase
HV243_03330	COG0187	DNA topoisomerase II activity
HV243_03335	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HV243_03340	COG2249	NAD(P)H dehydrogenase (quinone) activity
HV243_03355	COG3111	PFAM Bacterial OB fold (BOF) protein
HV243_03375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HV243_03390	COG0656	L-ascorbic acid biosynthetic process
HV243_03395	COG1979	alcohol dehydrogenase
HV243_03400	COG2207	Transcriptional regulator
HV243_03405	COG0586	Pfam SNARE associated Golgi protein
HV243_03410	COG0626	cystathionine gamma-synthase activity
HV243_03420	COG0848	biopolymer transport protein
HV243_03440	COG0667	Aldo Keto reductase
HV243_03450	COG0840	transmembrane signaling receptor activity
HV243_03460	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HV243_03465	COG0437	4 iron, 4 sulfur cluster binding
HV243_03470	COG5557	Pfam Polysulphide reductase, NrfD
HV243_03475	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HV243_03480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV243_03485	COG1773	rubredoxin
HV243_03495	COG0298	carbon dioxide binding
HV243_03500	COG0625	glutathione transferase activity
HV243_03505	COG0243	molybdopterin cofactor binding
HV243_03510	COG0754	glutathionylspermidine amidase activity
HV243_03530	COG1846	Transcriptional regulator
HV243_03665	COG3188	usher protein
HV243_03670	COG3121	Chaperone
HV243_03725	COG1216	Glycosyl transferase, family 2
HV243_03730	COG1442	glycosyl transferase family 8
HV243_03735	COG1216	Glycosyl transferase, family 2
HV243_03740	COG1216	Glycosyl transferase, family 2
HV243_03845	COG2003	Belongs to the UPF0758 family
HV243_03880	COG3596	GTP binding
HV243_03940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HV243_03950	COG1136	(ABC) transporter
HV243_04005	COG2826	transposase and inactivated derivatives, IS30 family
HV243_04040	COG0437	4 iron, 4 sulfur cluster binding
HV243_04045	COG3302	dmso reductase anchor subunit
HV243_04050	COG3381	protein complex oligomerization
HV243_04055	COG2221	Nitrite and sulphite reductase 4Fe-4S
HV243_04055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_04080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV243_04110	COG0582	viral genome integration into host DNA
HV243_04120	COG1811	Na channel or pump
HV243_04125	COG1982	Orn Lys Arg decarboxylase major
HV243_04130	COG2211	Major facilitator Superfamily
HV243_04145	COG1194	a g-specific adenine glycosylase
HV243_04155	COG3171	Protein conserved in bacteria
HV243_04165	COG0252	asparaginase activity
HV243_04175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HV243_04175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HV243_04180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV243_04185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV243_04200	COG0762	integral membrane protein
HV243_04205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HV243_04210	COG2805	Type II/IV secretion system protein
HV243_04225	COG0189	ligase activity
HV243_04230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HV243_04235	COG2356	endonuclease I
HV243_04240	COG3091	SprT-like family
HV243_04245	COG2814	Major facilitator Superfamily
HV243_04265	COG1166	arginine decarboxylase activity
HV243_04275	COG0501	Belongs to the peptidase M48B family
HV243_04280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV243_04285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_04290	COG2213	PTS system mannitol-specific
HV243_04295	COG1063	alcohol dehydrogenase
HV243_04300	COG1494	fructose-1,6-bisphosphatase
HV243_04310	COG1072	(Pantothenic acid kinase))
HV243_04325	COG0191	fructose-bisphosphate aldolase activity
HV243_04330	COG0549	Belongs to the carbamate kinase family
HV243_04335	COG2271	Major facilitator Superfamily
HV243_04340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV243_04345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV243_04355	COG0583	DNA-binding transcription factor activity
HV243_04360	COG0668	transmembrane transport
HV243_04370	COG1279	arginine transmembrane transporter activity
HV243_04375	COG2968	Membrane
HV243_04380	COG0583	DNA-binding transcription factor activity
HV243_04385	COG0427	acetyl-CoA hydrolase
HV243_04390	COG1024	Enoyl-CoA hydratase
HV243_04395	COG1703	isobutyryl-CoA mutase activity
HV243_04400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV243_04400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV243_04415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HV243_04420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HV243_04440	COG0006	proline dipeptidase activity
HV243_04445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV243_04450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV243_04470	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_04475	COG2723	6-phospho-beta-galactosidase activity
HV243_04480	COG1737	Transcriptional regulator
HV243_04490	COG1272	protein, Hemolysin III
HV243_04500	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HV243_04525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HV243_04545	COG4942	peptidase
HV243_04560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV243_04565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV243_04570	COG0457	Tetratricopeptide repeat
HV243_04575	COG0438	transferase activity, transferring glycosyl groups
HV243_04580	COG1596	polysaccharide export
HV243_04585	COG1682	transport, permease protein
HV243_04595	COG3039	Transposase
HV243_04605	COG3524	carbohydrate:proton symporter activity
HV243_04610	COG4783	chaperone-mediated protein folding
HV243_04610	COG1560	Kdo2-lipid A biosynthetic process
HV243_04620	COG0457	Tetratricopeptide repeat
HV243_04625	COG1649	PFAM Uncharacterised BCR, COG1649
HV243_04625	COG0726	polysaccharide deacetylase
HV243_04630	COG1215	transferase activity, transferring glycosyl groups
HV243_04640	COG3592	Divergent 4Fe-4S mono-cluster
HV243_04645	COG2388	GCN5-related N-acetyl-transferase
HV243_04650	COG0583	DNA-binding transcription factor activity
HV243_04655	COG0666	response to abiotic stimulus
HV243_04665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV243_04670	COG1304	FMN binding
HV243_04680	COG0549	Belongs to the carbamate kinase family
HV243_04685	COG0402	S-adenosylhomocysteine deaminase activity
HV243_04700	COG0814	amino acid
HV243_04715	COG0183	Belongs to the thiolase family
HV243_04720	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HV243_04725	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_04735	COG1794	racemase activity, acting on amino acids and derivatives
HV243_04740	COG0583	DNA-binding transcription factor activity
HV243_04750	COG1609	Transcriptional regulator
HV243_04770	COG0667	Aldo Keto reductase
HV243_04780	COG0861	Integral membrane protein TerC family
HV243_04815	COG2165	general secretion pathway protein
HV243_04820	COG4795	General secretion pathway protein
HV243_04830	COG4967	type IV pilus modification protein PilV
HV243_04835	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HV243_04845	COG1074	ATP-dependent DNA helicase activity
HV243_04850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HV243_04855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HV243_04855	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HV243_04860	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV243_04880	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HV243_04885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HV243_04890	COG2166	iron-sulfur cluster assembly
HV243_04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HV243_04905	COG0583	DNA-binding transcription factor activity
HV243_04910	COG2363	Small membrane protein
HV243_04920	COG1349	DNA-binding transcription factor activity
HV243_04940	COG1129	ABC transporter
HV243_04945	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_04955	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV243_04965	COG0235	Class ii aldolase
HV243_04970	COG1454	alcohol dehydrogenase
HV243_04980	COG1760	l-serine dehydratase
HV243_04985	COG0814	amino acid
HV243_04990	COG1611	Belongs to the LOG family
HV243_05005	COG3098	single-species biofilm formation
HV243_05010	COG0564	pseudouridine synthase activity
HV243_05015	COG0716	FMN binding
HV243_05020	COG2271	Major facilitator Superfamily
HV243_05025	COG4948	Mandelate Racemase Muconate Lactonizing
HV243_05030	COG4948	Mandelate Racemase Muconate Lactonizing
HV243_05035	COG1929	Belongs to the glycerate kinase type-1 family
HV243_05040	COG4999	Histidine kinase
HV243_05040	COG3850	Histidine kinase
HV243_05040	COG2205	protein histidine kinase activity
HV243_05040	COG3437	response regulator, receiver
HV243_05050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HV243_05055	COG3956	TIGRFAM MazG family protein
HV243_05105	COG3121	Chaperone
HV243_05125	COG0602	queuosine metabolic process
HV243_05130	COG1070	Carbohydrate kinase
HV243_05135	COG2223	nitrite transmembrane transporter activity
HV243_05140	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_05145	COG0277	FAD linked oxidase domain protein
HV243_05150	COG0477	Major facilitator Superfamily
HV243_05155	COG2086	electron transfer activity
HV243_05160	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV243_05165	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HV243_05170	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV243_05175	COG0644	oxidoreductase
HV243_05180	COG0720	synthase
HV243_05200	COG2234	aminopeptidase activity
HV243_05255	COG1388	LysM domain
HV243_05255	COG4942	peptidase
HV243_05295	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HV243_05305	COG3188	usher protein
HV243_05335	COG2200	EAL domain
HV243_05340	COG3710	Transcriptional regulator
HV243_05365	COG2200	EAL domain
HV243_05370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV243_05375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV243_05380	COG1121	(ABC) transporter
HV243_05400	COG0309	Hydrogenase expression formation protein (HypE)
HV243_05405	COG0409	Hydrogenase expression formation protein
HV243_05410	COG0298	carbon dioxide binding
HV243_05415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HV243_05430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_05435	COG0651	ATP synthesis coupled electron transport
HV243_05440	COG0650	Formate hydrogenlyase subunit 4
HV243_05445	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HV243_05445	COG3261	NADH dehydrogenase
HV243_05450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV243_05455	COG3260	NADH ubiquinone oxidoreductase 20
HV243_05465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV243_05480	COG2723	6-phospho-beta-galactosidase activity
HV243_05485	COG1263	PTS System
HV243_05485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_05490	COG1609	Transcriptional regulator
HV243_05495	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_05500	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HV243_05520	COG0517	IMP dehydrogenase activity
HV243_05520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV243_05525	COG1349	DNA-binding transcription factor activity
HV243_05530	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_05535	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_05545	COG3732	PTS system glucitol sorbitol-specific
HV243_05550	COG3730	PTS system glucitol sorbitol-specific
HV243_05555	COG2951	lytic endotransglycosylase activity
HV243_05560	COG1546	Belongs to the CinA family
HV243_05580	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HV243_05610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV243_05615	COG1238	metal cluster binding
HV243_05630	COG2814	Major facilitator Superfamily
HV243_05635	COG1566	PFAM secretion protein HlyD family protein
HV243_05640	COG1846	Transcriptional regulator
HV243_05650	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV243_05655	COG2814	Major facilitator Superfamily
HV243_05665	COG4176	ABC-type proline glycine betaine transport system permease component
HV243_05680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HV243_05695	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV243_05725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV243_05730	COG0640	Transcriptional regulator
HV243_05735	COG0401	homolog of Blt101
HV243_05740	COG1652	LysM domain
HV243_05745	COG1802	Transcriptional regulator
HV243_05750	COG1113	amino acid transport
HV243_05755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV243_05760	COG1012	belongs to the aldehyde dehydrogenase family
HV243_05765	COG0579	oxidoreductase
HV243_05805	COG0642	Histidine kinase
HV243_05815	COG3188	usher protein
HV243_05820	COG3121	Chaperone
HV243_05865	COG0438	transferase activity, transferring glycosyl groups
HV243_05870	COG0297	glycogen (starch) synthase activity
HV243_05870	COG0438	transferase activity, transferring glycosyl groups
HV243_05900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV243_05905	COG1757	Na H antiporter
HV243_05910	COG2169	Transcriptional regulator
HV243_05920	COG2197	response regulator
HV243_05925	COG2198	Histidine kinase
HV243_05925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV243_05925	COG0784	Response regulator, receiver
HV243_05925	COG2205	protein histidine kinase activity
HV243_05945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV243_05950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_05955	COG3065	identical protein binding
HV243_06040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_06065	COG2867	negative regulation of translational initiation
HV243_06080	COG0497	DNA recombination
HV243_06095	COG4536	flavin adenine dinucleotide binding
HV243_06100	COG4137	Cytochrome C assembly protein
HV243_06105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HV243_06130	COG2885	chlorophyll binding
HV243_06135	COG2199	diguanylate cyclase activity
HV243_06150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV243_06155	COG1605	Chorismate mutase
HV243_06155	COG0287	Prephenate dehydrogenase
HV243_06160	COG1605	Chorismate mutase
HV243_06160	COG0077	Prephenate dehydratase
HV243_06170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HV243_06175	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV243_06190	COG0542	response to heat
HV243_06215	COG0477	Major facilitator Superfamily
HV243_06220	COG5544	Lipoprotein
HV243_06225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV243_06240	COG3118	belongs to the thioredoxin family
HV243_06245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV243_06260	COG0513	Belongs to the DEAD box helicase family
HV243_06270	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HV243_06280	COG1595	DNA-templated transcription, initiation
HV243_06290	COG3026	antisigma factor binding
HV243_06295	COG3086	response to oxidative stress
HV243_06305	COG0681	Belongs to the peptidase S26 family
HV243_06325	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HV243_06335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_06340	COG1737	Transcriptional regulator
HV243_06345	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HV243_06350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_06350	COG1263	PTS System
HV243_06355	COG0560	Phosphoserine phosphatase
HV243_06375	COG2205	protein histidine kinase activity
HV243_06380	COG3170	Tfp pilus assembly protein FimV
HV243_06385	COG2204	response regulator
HV243_06390	COG0347	Belongs to the P(II) protein family
HV243_06395	COG1017	nitric oxide dioxygenase activity
HV243_06395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV243_06425	COG4638	Rieske (2fe-2S)
HV243_06430	COG0583	DNA-binding transcription factor activity
HV243_06435	COG1940	carbohydrate kinase activity
HV243_06440	COG0457	Tetratricopeptide repeat
HV243_06445	COG2814	Major facilitator Superfamily
HV243_06445	COG0477	Major facilitator Superfamily
HV243_06455	COG2814	Major facilitator Superfamily
HV243_06460	COG3711	transcriptional antiterminator
HV243_06465	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV243_06465	COG0517	IMP dehydrogenase activity
HV243_06470	COG1069	ribulokinase activity
HV243_06480	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_06485	COG1129	ABC transporter
HV243_06495	COG3683	transport system, periplasmic component
HV243_06500	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HV243_06525	COG0822	iron-sulfur transferase activity
HV243_06545	COG0633	Ferredoxin
HV243_06550	COG2975	iron-sulfur cluster assembly
HV243_06565	COG2897	thiosulfate sulfurtransferase activity
HV243_06570	COG2373	Large extracellular alpha-helical protein
HV243_06575	COG4953	penicillin-binding protein 1C
HV243_06605	COG2976	Protein conserved in bacteria
HV243_06620	COG3104	oligopeptide transport
HV243_06630	COG1645	bacterial-type flagellum-dependent swarming motility
HV243_06635	COG1570	exodeoxyribonuclease VII activity
HV243_06640	COG0516	GMP reductase activity
HV243_06640	COG0517	IMP dehydrogenase activity
HV243_06655	COG2200	EAL domain
HV243_06670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HV243_06680	COG2723	6-phospho-beta-galactosidase activity
HV243_06690	COG2233	PERMEase
HV243_06700	COG1393	Belongs to the ArsC family
HV243_06705	COG4783	chaperone-mediated protein folding
HV243_06710	COG0628	permease
HV243_06715	COG3366	ferrous iron transmembrane transporter activity
HV243_06720	COG0700	Nucleoside recognition
HV243_06725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV243_06730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HV243_06735	COG2716	regulation of RNA biosynthetic process
HV243_06745	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HV243_06755	COG2321	neutral zinc metallopeptidase
HV243_06765	COG0400	carboxylic ester hydrolase activity
HV243_06780	COG1393	Belongs to the ArsC family
HV243_06790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV243_06795	COG3850	Histidine kinase
HV243_06800	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_06800	COG0493	'glutamate synthase
HV243_06810	COG5342	invasion associated locus B
HV243_06815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HV243_06835	COG4766	ethanolamine catabolic process
HV243_06840	COG4812	Cobalamin adenosyltransferase
HV243_06905	COG2207	Transcriptional regulator
HV243_06915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV243_06935	COG2837	iron assimilation
HV243_06940	COG0165	Argininosuccinate lyase
HV243_06945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV243_06950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV243_06955	COG2186	Transcriptional regulator
HV243_06965	COG4150	thiosulfate binding
HV243_06970	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HV243_06975	COG4208	sulfate ABC transporter
HV243_06980	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HV243_07045	COG3530	Putative quorum-sensing-regulated virulence factor
HV243_07050	COG0385	Bile acid
HV243_07055	COG0583	DNA-binding transcription factor activity
HV243_07085	COG3415	Transposase
HV243_07090	COG3415	Transposase
HV243_07105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV243_07120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV243_07125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV243_07130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_07130	COG1263	PTS System
HV243_07140	COG0667	Aldo Keto reductase
HV243_07145	COG3961	Belongs to the TPP enzyme family
HV243_07160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_07165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_07170	COG0006	proline dipeptidase activity
HV243_07175	COG1363	Peptidase, m42
HV243_07190	COG2207	Transcriptional regulator
HV243_07195	COG3279	Response regulator of the LytR AlgR family
HV243_07200	COG3275	phosphorelay sensor kinase activity
HV243_07205	COG0436	Aminotransferase
HV243_07220	COG1560	Kdo2-lipid A biosynthetic process
HV243_07250	COG3122	Protein conserved in bacteria
HV243_07255	COG0840	transmembrane signaling receptor activity
HV243_07300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV243_07325	COG4712	double-strand break repair protein
HV243_07410	COG0305	Participates in initiation and elongation during chromosome replication
HV243_07470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV243_07500	COG3772	lysozyme
HV243_07535	COG1783	phage Terminase large subunit
HV243_07655	COG0463	Glycosyl transferase, family 2
HV243_07665	COG0582	viral genome integration into host DNA
HV243_07675	COG2116	formate transmembrane transporter activity
HV243_07685	COG2067	long-chain fatty acid transport protein
HV243_07690	COG3691	Protein conserved in bacteria
HV243_07705	COG2062	phosphohistidine phosphatase, SixA
HV243_07730	COG0730	response to heat
HV243_07735	COG3101	peptidyl-lysine hydroxylation
HV243_07750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV243_07790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HV243_07800	COG0586	Pfam SNARE associated Golgi protein
HV243_07810	COG0285	dihydrofolate synthase activity
HV243_07815	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HV243_07820	COG1286	toxin biosynthetic process
HV243_07825	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HV243_07830	COG0163	prenyltransferase activity
HV243_07840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV243_07855	COG4598	ABC transporter
HV243_07860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV243_07865	COG1090	epimerase
HV243_07870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HV243_07875	COG0625	glutathione transferase activity
HV243_07880	COG0625	glutathione transferase activity
HV243_07885	COG0622	Phosphoesterase
HV243_07895	COG1288	antiporter activity
HV243_07920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV243_07925	COG0490	domain, Protein
HV243_07925	COG0471	metal ion transport
HV243_07935	COG0436	Aminotransferase
HV243_07940	COG0583	DNA-binding transcription factor activity
HV243_07960	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HV243_07985	COG0839	Belongs to the complex I subunit 6 family
HV243_07995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HV243_08000	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV243_08010	COG0835	chemotaxis
HV243_08010	COG0784	Response regulator, receiver
HV243_08020	COG2153	protein acetylation
HV243_08025	COG4575	ribosome binding
HV243_08030	COG1169	isochorismate synthase
HV243_08115	COG1414	Transcriptional regulator
HV243_08125	COG2271	Major facilitator Superfamily
HV243_08145	COG0247	lactate metabolic process
HV243_08155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HV243_08160	COG2271	Major facilitator Superfamily
HV243_08165	COG0584	glycerophosphoryl diester phosphodiesterase
HV243_08170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV243_08195	COG0183	Belongs to the thiolase family
HV243_08200	COG2031	fatty acid transporter
HV243_08205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV243_08210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV243_08215	COG2204	response regulator
HV243_08220	COG3852	Histidine kinase
HV243_08235	COG0642	Histidine kinase
HV243_08235	COG2198	Histidine kinase
HV243_08245	COG1477	protein flavinylation
HV243_08250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HV243_08250	COG2169	Transcriptional regulator
HV243_08255	COG3145	DNA-N1-methyladenine dioxygenase activity
HV243_08260	COG4615	Cyclic peptide transporter
HV243_08265	COG2239	Acts as a magnesium transporter
HV243_08270	COG0659	secondary active sulfate transmembrane transporter activity
HV243_08285	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_08285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HV243_08290	COG3062	negative regulation of establishment of protein localization
HV243_08300	COG0437	4 iron, 4 sulfur cluster binding
HV243_08305	COG0348	domain, Protein
HV243_08310	COG3043	anaerobic respiration
HV243_08315	COG3005	denitrification pathway
HV243_08320	COG4133	protoheme IX ABC transporter activity
HV243_08330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV243_08335	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HV243_08345	COG1138	Cytochrome C-type biogenesis protein
HV243_08350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV243_08355	COG3088	subunit of a heme lyase
HV243_08355	COG4235	cytochrome complex assembly
HV243_08360	COG2197	response regulator
HV243_08390	COG1061	Type III restriction enzyme res subunit
HV243_08395	COG1187	pseudouridine synthase activity
HV243_08400	COG2814	Major facilitator Superfamily
HV243_08410	COG4172	Belongs to the ABC transporter superfamily
HV243_08415	COG4239	(ABC) transporter, permease
HV243_08420	COG4174	ABC transporter (Permease)
HV243_08425	COG4166	transmembrane transport
HV243_08430	COG2200	EAL domain
HV243_08435	COG0791	NLP P60 protein
HV243_08440	COG0671	phosphoesterase, PA-phosphatase related
HV243_08445	COG0523	cobalamin synthesis protein
HV243_08450	COG0246	Mannitol dehydrogenase
HV243_08455	COG1312	Catalyzes the dehydration of D-mannonate
HV243_08460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV243_08465	COG3005	denitrification pathway
HV243_08475	COG3381	protein complex oligomerization
HV243_08500	COG1105	Belongs to the carbohydrate kinase PfkB family
HV243_08505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_08505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_08505	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HV243_08510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV243_08520	COG0583	DNA-binding transcription factor activity
HV243_08525	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_08530	COG2313	pseudouridylate synthase activity
HV243_08535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV243_08540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_08540	COG1522	sequence-specific DNA binding
HV243_08550	COG2855	membrane
HV243_08555	COG0583	DNA-binding transcription factor activity
HV243_08560	COG0833	amino acid
HV243_08565	COG4771	TonB-dependent receptor
HV243_08580	COG2311	Membrane
HV243_08595	COG1129	ABC transporter
HV243_08610	COG0493	'glutamate synthase
HV243_08620	COG2949	membrane
HV243_08630	COG1346	cytolysis
HV243_08645	COG2271	Major facilitator Superfamily
HV243_08660	COG0625	glutathione transferase activity
HV243_08665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV243_08670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV243_08685	COG0586	Pfam SNARE associated Golgi protein
HV243_08695	COG1686	Belongs to the peptidase S11 family
HV243_08700	COG0277	FAD linked oxidase domain protein
HV243_08705	COG1472	Belongs to the glycosyl hydrolase 3 family
HV243_08710	COG1732	Glycine betaine
HV243_08715	COG1174	glycine betaine transport
HV243_08720	COG1125	glycine betaine transport
HV243_08725	COG1174	glycine betaine transport
HV243_08735	COG0789	Transcriptional regulator
HV243_08740	COG3275	phosphorelay sensor kinase activity
HV243_08750	COG4807	Protein conserved in bacteria
HV243_08755	COG4808	Protein conserved in bacteria
HV243_08780	COG3121	Chaperone
HV243_08785	COG3188	usher protein
HV243_08795	COG5455	response to cobalt ion
HV243_08900	COG0351	phosphomethylpyrimidine kinase
HV243_08905	COG2188	Transcriptional regulator
HV243_08910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_08915	COG1397	ADP-ribosylglycohydrolase
HV243_08920	COG2211	Major facilitator Superfamily
HV243_08925	COG1830	Aldolase
HV243_08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV243_08940	COG4160	amino acid transport
HV243_08945	COG4215	(ABC) transporter
HV243_08950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV243_08955	COG1126	abc transporter atp-binding protein
HV243_08970	COG3023	N-Acetylmuramoyl-L-alanine amidase
HV243_08975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV243_08980	COG0702	epimerase
HV243_08985	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HV243_08990	COG0028	Belongs to the TPP enzyme family
HV243_09000	COG4529	Protein conserved in bacteria
HV243_09005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV243_09015	COG2431	L-lysine efflux transmembrane transporter activity
HV243_09025	COG3593	DNA synthesis involved in DNA repair
HV243_09030	COG2990	Protein conserved in bacteria
HV243_09035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_09045	COG1278	Cold shock
HV243_09055	COG0542	response to heat
HV243_09070	COG0745	RESPONSE REGULATOR receiver
HV243_09075	COG2205	protein histidine kinase activity
HV243_09105	COG0443	Heat shock 70 kDa protein
HV243_09110	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HV243_09115	COG5001	Diguanylate cyclase
HV243_09115	COG5002	protein histidine kinase activity
HV243_09115	COG3447	MASE1 domain protein
HV243_09130	COG2982	Protein involved in outer membrane biogenesis
HV243_09135	COG1253	flavin adenine dinucleotide binding
HV243_09155	COG0463	Glycosyl transferase, family 2
HV243_09160	COG1045	serine acetyltransferase
HV243_09165	COG0438	transferase activity, transferring glycosyl groups
HV243_09175	COG1216	Glycosyl transferase, family 2
HV243_09180	COG0110	maltose O-acetyltransferase activity
HV243_09185	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HV243_09190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV243_09195	COG1051	belongs to the nudix hydrolase family
HV243_09200	COG0297	glycogen (starch) synthase activity
HV243_09205	COG0662	Cupin 2, conserved barrel domain protein
HV243_09205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HV243_09210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HV243_09215	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HV243_09220	COG2244	polysaccharide biosynthetic process
HV243_09225	COG2327	Polysaccharide pyruvyl transferase
HV243_09240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV243_09250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV243_09280	COG0463	Glycosyl transferase, family 2
HV243_09280	COG1216	Glycosyl transferase, family 2
HV243_09290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HV243_09305	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV243_09325	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HV243_09355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HV243_09360	COG0583	DNA-binding transcription factor activity
HV243_09370	COG0531	amino acid
HV243_09375	COG2925	Exonuclease
HV243_09405	COG1289	transmembrane transporter activity
HV243_09440	COG4656	Part of a membrane complex involved in electron transport
HV243_09450	COG1012	belongs to the aldehyde dehydrogenase family
HV243_09630	COG1376	ErfK ybiS ycfS ynhG family protein
HV243_09635	COG3842	ATPase activity
HV243_09640	COG1178	ABC-type Fe3 transport system permease component
HV243_09645	COG1840	ABC-type Fe3 transport system, periplasmic component
HV243_09700	COG4227	nucleotidyltransferase activity
HV243_09720	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HV243_09730	COG3504	Conjugal transfer protein
HV243_09760	COG3451	type IV secretory pathway VirB4
HV243_09780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV243_09810	COG1566	PFAM secretion protein HlyD family protein
HV243_09815	COG2814	Major facilitator Superfamily
HV243_09820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV243_09825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV243_09830	COG1845	cytochrome c oxidase, subunit III
HV243_09835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV243_09845	COG3039	Transposase
HV243_09855	COG0582	viral genome integration into host DNA
HV243_09875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV243_09880	COG1418	mRNA catabolic process
HV243_09885	COG0270	DNA (cytosine-5-)-methyltransferase activity
HV243_09895	COG0697	spore germination
HV243_09900	COG2354	Protein conserved in bacteria
HV243_09905	COG5475	Uncharacterized small protein (DUF2158)
HV243_09965	COG2882	bacterial-type flagellum organization
HV243_09995	COG0425	Belongs to the sulfur carrier protein TusA family
HV243_10010	COG0366	Alpha amylase catalytic
HV243_10065	COG2197	response regulator
HV243_10075	COG2197	response regulator
HV243_10110	COG1278	Cold shock
HV243_10125	COG0431	NADPH-dependent FMN reductase
HV243_10130	COG0640	Transcriptional regulator
HV243_10160	COG1305	Transglutaminase-like
HV243_10170	COG2608	mercury ion transmembrane transporter activity
HV243_10175	COG3318	Belongs to the UPF0149 family
HV243_10175	COG3012	SEC-C Motif Domain Protein
HV243_10180	COG0814	amino acid
HV243_10190	COG1528	Iron-storage protein
HV243_10205	COG0477	Major facilitator Superfamily
HV243_10215	COG1528	Iron-storage protein
HV243_10225	COG1879	ABC-type sugar transport system periplasmic component
HV243_10230	COG1129	ABC transporter
HV243_10235	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_10280	COG0835	chemotaxis
HV243_10285	COG1301	dicarboxylic acid transport
HV243_10295	COG0840	transmembrane signaling receptor activity
HV243_10310	COG0745	RESPONSE REGULATOR receiver
HV243_10320	COG4977	sequence-specific DNA binding
HV243_10325	COG2814	Major facilitator Superfamily
HV243_10330	COG3250	beta-galactosidase activity
HV243_10355	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HV243_10370	COG3102	Protein conserved in bacteria
HV243_10390	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HV243_10395	COG1801	Protein of unknown function DUF72
HV243_10400	COG0582	viral genome integration into host DNA
HV243_10485	COG1484	DNA-dependent DNA replication
HV243_10510	COG3772	lysozyme
HV243_10545	COG1802	Transcriptional regulator
HV243_10545	COG4626	Terminase
HV243_10655	COG1335	isochorismatase
HV243_10665	COG0494	nUDIX hydrolase
HV243_10685	COG2255	four-way junction helicase activity
HV243_10690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HV243_10710	COG1187	pseudouridine synthase activity
HV243_10715	COG0538	isocitrate dehydrogenase activity
HV243_10720	COG2814	Major facilitator Superfamily
HV243_10725	COG1414	Transcriptional regulator
HV243_10755	COG0768	penicillin binding
HV243_10760	COG2226	methyltransferase
HV243_10775	COG3716	PTS system mannose fructose sorbose family IID component
HV243_10780	COG3715	PTS system
HV243_10785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_10785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_10790	COG1253	flavin adenine dinucleotide binding
HV243_10795	COG2200	EAL domain
HV243_10800	COG1760	l-serine dehydratase
HV243_10820	COG0251	oxidation-reduction process
HV243_10825	COG1199	ATP-dependent helicase activity
HV243_10830	COG1214	PFAM Peptidase M22, glycoprotease
HV243_10835	COG3065	identical protein binding
HV243_10840	COG0318	PFAM AMP-dependent synthetase and ligase
HV243_10845	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HV243_10850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HV243_10855	COG4638	Rieske (2fe-2S)
HV243_10860	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HV243_10865	COG0473	3-isopropylmalate dehydrogenase activity
HV243_10870	COG0583	DNA-binding transcription factor activity
HV243_10880	COG2894	cell division
HV243_10895	COG0179	Fumarylacetoacetate (FAA) hydrolase
HV243_10915	COG0463	Glycosyl transferase, family 2
HV243_10920	COG2246	polysaccharide biosynthetic process
HV243_10945	COG2719	SpoVR family
HV243_10955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HV243_10965	COG1619	proteins homologs of microcin C7 resistance protein MccF
HV243_10990	COG0157	Belongs to the NadC ModD family
HV243_10995	COG0500	methyltransferase
HV243_11000	COG1120	ATPase activity
HV243_11025	COG1461	Dihydroxyacetone kinase
HV243_11030	COG2376	Dihydroxyacetone kinase
HV243_11035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HV243_11060	COG0789	Transcriptional regulator
HV243_11065	COG2200	EAL domain
HV243_11095	COG0702	epimerase
HV243_11105	COG0667	Aldo Keto reductase
HV243_11110	COG0656	L-ascorbic acid biosynthetic process
HV243_11115	COG0641	radical SAM
HV243_11120	COG2190	(PTS) system
HV243_11120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_11120	COG1263	PTS System
HV243_11135	COG1737	Transcriptional regulator
HV243_11140	COG2149	membrane
HV243_11195	COG5002	protein histidine kinase activity
HV243_11210	COG0012	GTP binding
HV243_11225	COG0527	aspartate kinase activity
HV243_11230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV243_11235	COG0076	glutamate decarboxylase activity
HV243_11240	COG0659	secondary active sulfate transmembrane transporter activity
HV243_11270	COG2890	protein-(glutamine-N5) methyltransferase activity
HV243_11275	COG3094	Invasion gene expression up-regulator, SirB
HV243_11290	COG0387	Pfam Sodium calcium exchanger
HV243_11295	COG4572	Cation transport regulator
HV243_11300	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HV243_11310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HV243_11315	COG4932	domain protein
HV243_11320	COG2197	response regulator
HV243_11325	COG3850	Histidine kinase
HV243_11330	COG2223	nitrite transmembrane transporter activity
HV243_11335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV243_11340	COG1140	nitrate reductase beta subunit
HV243_11345	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV243_11350	COG2181	nitrate reductase activity
HV243_11380	COG0788	formyltetrahydrofolate deformylase activity
HV243_11390	COG1752	Esterase of the alpha-beta hydrolase superfamily
HV243_11395	COG0745	RESPONSE REGULATOR receiver
HV243_11400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HV243_11410	COG1435	thymidine kinase activity
HV243_11415	COG1012	belongs to the aldehyde dehydrogenase family
HV243_11415	COG1454	alcohol dehydrogenase
HV243_11420	COG2095	MarC family integral membrane protein
HV243_11440	COG0444	Belongs to the ABC transporter superfamily
HV243_11450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV243_11485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV243_11525	COG1484	DNA-dependent DNA replication
HV243_11595	COG3772	lysozyme
HV243_11735	COG1196	nuclear chromosome segregation
HV243_11775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV243_11815	COG2350	Protein conserved in bacteria
HV243_11840	COG3047	cAMP biosynthetic process
HV243_11850	COG3706	GGDEF domain
HV243_11885	COG0613	PHP domain protein
HV243_11890	COG0009	L-threonylcarbamoyladenylate synthase
HV243_11895	COG1187	pseudouridine synthase activity
HV243_11905	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_11910	COG0616	signal peptide processing
HV243_11925	COG0583	DNA-binding transcription factor activity
HV243_11940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HV243_11950	COG0671	phosphoesterase, PA-phosphatase related
HV243_11955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HV243_11960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HV243_11970	COG0023	Translation Initiation Factor
HV243_11980	COG1349	DNA-binding transcription factor activity
HV243_11990	COG5001	Diguanylate cyclase
HV243_12000	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV243_12000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV243_12005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HV243_12020	COG4172	Belongs to the ABC transporter superfamily
HV243_12025	COG4171	peptide transport system, permease
HV243_12050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HV243_12055	COG1842	Phage shock protein A
HV243_12065	COG1983	PspC domain protein
HV243_12075	COG0366	Alpha amylase catalytic
HV243_12080	COG1653	transport
HV243_12085	COG1175	transmembrane transport
HV243_12090	COG0395	ABC-type sugar transport system, permease component
HV243_12095	COG1063	alcohol dehydrogenase
HV243_12100	COG1082	Xylose isomerase domain protein TIM barrel
HV243_12105	COG0673	inositol 2-dehydrogenase activity
HV243_12110	COG1554	hydrolase, family 65, central catalytic
HV243_12115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV243_12130	COG1609	Transcriptional regulator
HV243_12135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HV243_12140	COG3106	COG3106 Predicted ATPase
HV243_12155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HV243_12160	COG4948	Mandelate Racemase Muconate Lactonizing
HV243_12165	COG2866	Carboxypeptidase
HV243_12170	COG4166	transmembrane transport
HV243_12175	COG1349	DNA-binding transcription factor activity
HV243_12180	COG0346	lactoylglutathione lyase activity
HV243_12190	COG0668	transmembrane transport
HV243_12195	COG3182	Iron-regulated membrane protein
HV243_12215	COG2840	Smr protein MutS2
HV243_12220	COG3706	GGDEF domain
HV243_12230	COG0840	transmembrane signaling receptor activity
HV243_12245	COG0513	Belongs to the DEAD box helicase family
HV243_12255	COG0589	response to stress
HV243_12265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV243_12270	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HV243_12270	COG1013	pyruvate-flavodoxin oxidoreductase activity
HV243_12270	COG0674	pyruvate-flavodoxin oxidoreductase activity
HV243_12270	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HV243_12275	COG3042	response to heat
HV243_12280	COG3187	Heat shock protein
HV243_12285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HV243_12290	COG2911	Protein conserved in bacteria
HV243_12300	COG3784	Protein of unknown function (DUF1318)
HV243_12315	COG1643	Atp-dependent helicase
HV243_12320	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV243_12325	COG1012	belongs to the aldehyde dehydrogenase family
HV243_12330	COG3038	cytochrome b561
HV243_12335	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HV243_12340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HV243_12360	COG0840	transmembrane signaling receptor activity
HV243_12365	COG0583	DNA-binding transcription factor activity
HV243_12370	COG1227	inorganic diphosphatase activity
HV243_12375	COG5383	Protein conserved in bacteria
HV243_12385	COG2841	Protein conserved in bacteria
HV243_12390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV243_12395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HV243_12400	COG1275	C4-dicarboxylate transporter malic acid transport protein
HV243_12405	COG0500	methyltransferase
HV243_12415	COG0697	spore germination
HV243_12425	COG3135	benzoate transporter
HV243_12430	COG1396	sequence-specific DNA binding
HV243_12435	COG0826	peptidase U32
HV243_12450	COG1294	oxidase, subunit
HV243_12455	COG1271	oxidase subunit
HV243_12460	COG1724	mRNA binding
HV243_12465	COG1598	PFAM Uncharacterised protein family UPF0150
HV243_12470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV243_12475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV243_12480	COG3842	ATPase activity
HV243_12485	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV243_12490	COG1177	transmembrane transport
HV243_12500	COG2814	Major facilitator Superfamily
HV243_12535	COG0747	negative chemotaxis
HV243_12545	COG3238	Protein conserved in bacteria
HV243_12550	COG1247	-acetyltransferase
HV243_12560	COG2130	NADP-dependent
HV243_12565	COG4772	TonB-dependent receptor
HV243_12605	COG0840	transmembrane signaling receptor activity
HV243_12610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV243_12615	COG1473	amidohydrolase
HV243_12620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HV243_12625	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HV243_12640	COG1126	abc transporter atp-binding protein
HV243_12645	COG0625	glutathione transferase activity
HV243_12650	COG2271	Major facilitator Superfamily
HV243_12660	COG1609	Transcriptional regulator
HV243_12670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HV243_12675	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HV243_12680	COG0384	phenazine biosynthesis protein PhzF
HV243_12685	COG2181	nitrate reductase activity
HV243_12690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HV243_12695	COG1140	nitrate reductase beta subunit
HV243_12700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HV243_12705	COG2223	nitrite transmembrane transporter activity
HV243_12740	COG0437	4 iron, 4 sulfur cluster binding
HV243_12745	COG2864	formate dehydrogenase
HV243_12750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HV243_12770	COG1764	response to oxidative stress
HV243_12775	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_12780	COG2610	gluconate transmembrane transporter activity
HV243_12785	COG0824	Thioesterase
HV243_12785	COG1250	3-hydroxyacyl-CoA dehydrogenase
HV243_12795	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HV243_12800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HV243_12810	COG4608	Belongs to the ABC transporter superfamily
HV243_12815	COG0444	Belongs to the ABC transporter superfamily
HV243_12820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV243_12825	COG0601	transmembrane transport
HV243_12830	COG0747	negative chemotaxis
HV243_12835	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HV243_12850	COG0840	transmembrane signaling receptor activity
HV243_12860	COG4628	conserved protein (DUF2132)
HV243_12880	COG3781	membrane
HV243_12905	COG1012	belongs to the aldehyde dehydrogenase family
HV243_12910	COG0583	DNA-binding transcription factor activity
HV243_12925	COG1846	Transcriptional regulator
HV243_12940	COG0697	spore germination
HV243_12945	COG2814	Major facilitator Superfamily
HV243_12955	COG1122	ATPase activity
HV243_12980	COG0339	signal peptide processing
HV243_12985	COG4221	oxidoreductase activity
HV243_12990	COG1802	Transcriptional regulator
HV243_13000	COG0246	Mannitol dehydrogenase
HV243_13005	COG0477	Major facilitator Superfamily
HV243_13010	COG1063	alcohol dehydrogenase
HV243_13015	COG4948	Mandelate Racemase Muconate Lactonizing
HV243_13030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV243_13045	COG0243	molybdopterin cofactor binding
HV243_13050	COG0437	4 iron, 4 sulfur cluster binding
HV243_13055	COG3302	dmso reductase anchor subunit
HV243_13060	COG3381	protein complex oligomerization
HV243_13070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV243_13075	COG1940	carbohydrate kinase activity
HV243_13080	COG0583	DNA-binding transcription factor activity
HV243_13085	COG2814	Major facilitator Superfamily
HV243_13095	COG5002	protein histidine kinase activity
HV243_13100	COG0745	RESPONSE REGULATOR receiver
HV243_13115	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HV243_13125	COG3591	Belongs to the peptidase S1B family
HV243_13140	COG0628	permease
HV243_13145	COG2814	Major facilitator Superfamily
HV243_13150	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HV243_13155	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HV243_13165	COG0531	amino acid
HV243_13175	COG3136	membrane protein required for alginate biosynthesis
HV243_13180	COG0745	RESPONSE REGULATOR receiver
HV243_13185	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HV243_13195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV243_13205	COG2205	protein histidine kinase activity
HV243_13220	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_13220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_13225	COG1482	cell wall glycoprotein biosynthetic process
HV243_13230	COG5339	Protein conserved in bacteria
HV243_13235	COG1609	Transcriptional regulator
HV243_13240	COG1263	PTS System
HV243_13240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_13245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HV243_13255	COG0673	inositol 2-dehydrogenase activity
HV243_13295	COG4659	FMN binding
HV243_13305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HV243_13315	COG0625	glutathione transferase activity
HV243_13320	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HV243_13335	COG3895	Periplasmic Protein
HV243_13360	COG1566	PFAM secretion protein HlyD family protein
HV243_13375	COG4989	oxidoreductase activity
HV243_13380	COG3313	Fe-S protein
HV243_13385	COG1309	transcriptional regulator
HV243_13390	COG1902	pentaerythritol trinitrate reductase activity
HV243_13395	COG0346	lactoylglutathione lyase activity
HV243_13405	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HV243_13410	COG0791	NLP P60 protein
HV243_13415	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HV243_13420	COG2814	Major facilitator Superfamily
HV243_13435	COG0583	DNA-binding transcription factor activity
HV243_13440	COG2814	Major facilitator Superfamily
HV243_13445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HV243_13450	COG0307	riboflavin synthase, alpha
HV243_13460	COG0564	pseudouridine synthase activity
HV243_13475	COG0251	oxidation-reduction process
HV243_13495	COG5001	Diguanylate cyclase
HV243_13495	COG3300	MHYT domain
HV243_13500	COG3272	Protein of unknown function (DUF1722)
HV243_13505	COG0628	permease
HV243_13525	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_13535	COG0583	DNA-binding transcription factor activity
HV243_13540	COG0477	Major facilitator Superfamily
HV243_13555	COG1942	4-Oxalocrotonate Tautomerase
HV243_13565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV243_13575	COG0251	oxidation-reduction process
HV243_13590	COG1114	Component of the transport system for branched-chain amino acids
HV243_13600	COG0583	DNA-binding transcription factor activity
HV243_13620	COG4977	sequence-specific DNA binding
HV243_13630	COG0386	Belongs to the glutathione peroxidase family
HV243_13665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HV243_13680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HV243_13690	COG1012	belongs to the aldehyde dehydrogenase family
HV243_13705	COG1113	amino acid transport
HV243_13715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV243_13725	COG0765	amino acid transport
HV243_13730	COG0765	amino acid transport
HV243_13740	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HV243_13745	COG0437	4 iron, 4 sulfur cluster binding
HV243_13755	COG2414	aldehyde ferredoxin oxidoreductase
HV243_13760	COG0437	4 iron, 4 sulfur cluster binding
HV243_13795	COG1464	Belongs to the NlpA lipoprotein family
HV243_13800	COG2011	ABC-type metal ion transport system permease component
HV243_13820	COG1376	ErfK ybiS ycfS ynhG family protein
HV243_13835	COG0719	Fe-S assembly protein
HV243_13840	COG0396	ATPase activity
HV243_13845	COG0719	Fe-S assembly protein
HV243_13850	COG0316	Belongs to the HesB IscA family
HV243_13875	COG2050	protein possibly involved in aromatic compounds catabolism
HV243_13880	COG0247	lactate metabolic process
HV243_13880	COG0277	FAD linked oxidase domain protein
HV243_13885	COG0628	permease
HV243_13900	COG0738	Major facilitator superfamily
HV243_13905	COG3039	Transposase
HV243_13910	COG2271	Major facilitator Superfamily
HV243_13925	COG4670	ketone body catabolic process
HV243_13930	COG1960	acyl-CoA dehydrogenase activity
HV243_13935	COG1917	Cupin 2, conserved barrel domain protein
HV243_13935	COG2207	Transcriptional regulator
HV243_13940	COG2086	electron transfer activity
HV243_13945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HV243_13950	COG0644	oxidoreductase
HV243_13955	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HV243_13960	COG0318	PFAM AMP-dependent synthetase and ligase
HV243_13965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV243_13965	COG0574	Belongs to the PEP-utilizing enzyme family
HV243_13975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV243_13980	COG4256	Hemin uptake protein
HV243_13985	COG4771	TonB-dependent receptor
HV243_13990	COG3720	iron ion transport
HV243_13995	COG4558	Periplasmic binding protein
HV243_14000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV243_14020	COG0791	NLP P60 protein
HV243_14030	COG0386	Belongs to the glutathione peroxidase family
HV243_14045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_14060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HV243_14090	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HV243_14105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HV243_14215	COG2369	cell adhesion
HV243_14225	COG1783	phage Terminase large subunit
HV243_14250	COG3772	lysozyme
HV243_14280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HV243_14475	COG3137	Salt-induced outer membrane protein
HV243_14480	COG1105	Belongs to the carbohydrate kinase PfkB family
HV243_14485	COG3001	Fructosamine kinase
HV243_14495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV243_14505	COG1988	membrane-bound metal-dependent
HV243_14520	COG0753	catalase activity
HV243_14530	COG1486	melibiose metabolic process
HV243_14535	COG1917	Cupin 2, conserved barrel domain protein
HV243_14535	COG2169	Transcriptional regulator
HV243_14540	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV243_14545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV243_14550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV243_14555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV243_14565	COG0322	excinuclease ABC activity
HV243_14575	COG3678	ATP-independent chaperone mediated protein folding
HV243_14605	COG0708	Exodeoxyribonuclease III
HV243_14610	COG0398	Pfam SNARE associated Golgi protein
HV243_14615	COG0398	Pfam SNARE associated Golgi protein
HV243_14620	COG4134	Bacterial extracellular solute-binding protein
HV243_14625	COG4135	transport system, permease component
HV243_14630	COG4136	ATPase activity
HV243_14635	COG2897	thiosulfate sulfurtransferase activity
HV243_14640	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HV243_14645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HV243_14650	COG0494	nUDIX hydrolase
HV243_14665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HV243_14675	COG0778	Nitroreductase
HV243_14680	COG0616	signal peptide processing
HV243_14685	COG0252	asparaginase activity
HV243_14690	COG1335	isochorismatase
HV243_14705	COG3139	Protein of unknown function (DUF1315)
HV243_14725	COG0656	L-ascorbic acid biosynthetic process
HV243_14740	COG3713	MltA-interacting MipA family protein
HV243_14745	COG2766	serine protein kinase
HV243_14755	COG0110	maltose O-acetyltransferase activity
HV243_14765	COG2226	methyltransferase
HV243_14770	COG2199	diguanylate cyclase activity
HV243_14775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV243_14785	COG2207	Transcriptional regulator
HV243_14790	COG2807	transmembrane transport
HV243_14795	COG0504	CTP synthase activity
HV243_14800	COG3189	MarR family transcriptional regulator
HV243_14805	COG3042	response to heat
HV243_14810	COG2199	diguanylate cyclase activity
HV243_14810	COG2203	Gaf domain
HV243_14825	COG2261	transglycosylase associated protein
HV243_14830	COG3383	formate dehydrogenase (NAD+) activity
HV243_14845	COG3615	Tellurite resistance protein tehB
HV243_14855	COG3443	Belongs to the bacterial solute-binding protein 9 family
HV243_14860	COG1124	(ABC) transporter
HV243_14870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HV243_14875	COG0601	transmembrane transport
HV243_14880	COG0747	negative chemotaxis
HV243_14885	COG4771	TonB-dependent receptor
HV243_14905	COG1956	GAF domain-containing protein
HV243_14910	COG2995	paraquat-inducible protein a
HV243_14915	COG3008	intermembrane lipid transfer
HV243_15050	COG3566	protein conserved in bacteria
HV243_15085	COG3772	lysozyme
HV243_15095	COG0484	heat shock protein binding
HV243_15150	COG1484	DNA-dependent DNA replication
HV243_15200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV243_15225	COG0582	viral genome integration into host DNA
HV243_15235	COG1276	copper resistance
HV243_15240	COG2372	response to copper ion
HV243_15250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV243_15255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV243_15260	COG1770	oligopeptidase
HV243_15265	COG2979	Protein of unknown function (DUF533)
HV243_15275	COG3141	response to X-ray
HV243_15285	COG0800	Aldolase
HV243_15290	COG0129	dihydroxy-acid dehydratase activity
HV243_15295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HV243_15300	COG1737	Transcriptional regulator
HV243_15310	COG1560	Kdo2-lipid A biosynthetic process
HV243_15315	COG0739	heme binding
HV243_15320	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HV243_15330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HV243_15355	COG2850	peptidyl-arginine hydroxylation
HV243_15380	COG3459	Glycosyltransferase 36 associated
HV243_15405	COG1289	transmembrane transporter activity
HV243_15420	COG1278	Cold shock
HV243_15435	COG1177	transmembrane transport
HV243_15445	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HV243_15455	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV243_15460	COG1136	(ABC) transporter
HV243_15465	COG4591	ABC-type transport system involved in lipoprotein release permease component
HV243_15470	COG4763	Acyl-transferase
HV243_15475	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HV243_15480	COG1376	ErfK ybiS ycfS ynhG family protein
HV243_15480	COG1388	LysM domain
HV243_15490	COG1309	transcriptional regulator
HV243_15500	COG3134	Outer membrane lipoprotein
HV243_15505	COG1252	NADH dehydrogenase
HV243_15535	COG5633	Lipoprotein
HV243_15540	COG0537	adenosine 5'-monophosphoramidase activity
HV243_15545	COG4773	Receptor
HV243_15555	COG0534	Mate efflux family protein
HV243_15565	COG0583	DNA-binding transcription factor activity
HV243_15585	COG0477	Major facilitator Superfamily
HV243_15590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HV243_15605	COG0084	hydrolase, TatD family'
HV243_15610	COG0470	DNA polymerase III
HV243_15620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HV243_15625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV243_15635	COG3121	Chaperone
HV243_15660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HV243_15695	COG1399	metal-binding, possibly nucleic acid-binding protein
HV243_15705	COG0564	pseudouridine synthase activity
HV243_15710	COG1530	ribonuclease E activity
HV243_15740	COG4786	Flagellar basal body rod
HV243_15745	COG4787	bacterial-type flagellum-dependent cell motility
HV243_15760	COG1558	bacterial-type flagellum-dependent cell motility
HV243_15800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HV243_15840	COG3038	cytochrome b561
HV243_15855	COG1560	Kdo2-lipid A biosynthetic process
HV243_15870	COG5645	(Lipo)protein
HV243_15890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV243_15945	COG3381	protein complex oligomerization
HV243_15970	COG1702	phosphate starvation-inducible protein PhoH
HV243_15995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HV243_16000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV243_16000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV243_16000	COG0506	proline dehydrogenase activity
HV243_16005	COG3755	Protein conserved in bacteria
HV243_16010	COG1309	transcriptional regulator
HV243_16020	COG3729	General stress protein
HV243_16040	COG0640	Transcriptional regulator
HV243_16050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HV243_16055	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HV243_16055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV243_16105	COG0813	purine-nucleoside phosphorylase activity
HV243_16110	COG2246	polysaccharide biosynthetic process
HV243_16130	COG4166	transmembrane transport
HV243_16135	COG0670	Belongs to the BI1 family
HV243_16175	COG2920	part of a sulfur-relay system
HV243_16195	COG1832	CoA-binding protein
HV243_16210	COG0210	DNA helicase
HV243_16215	COG3304	Inner membrane component domain
HV243_16220	COG1289	transmembrane transporter activity
HV243_16225	COG3070	regulator of competence-specific genes
HV243_16245	COG1067	ATP-dependent peptidase activity
HV243_16255	COG3130	regulation of translation
HV243_16260	COG3009	Protein conserved in bacteria
HV243_16265	COG3008	intermembrane lipid transfer
HV243_16265	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HV243_16270	COG2995	paraquat-inducible protein a
HV243_16275	COG0488	(ABC) transporter
HV243_16285	COG3217	Mosc domain protein beta barrel domain protein
HV243_16285	COG0633	Ferredoxin
HV243_16300	COG0431	NADPH-dependent FMN reductase
HV243_16305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HV243_16315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HV243_16325	COG0308	aminopeptidase N
HV243_16340	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV243_16345	COG1448	Aminotransferase
HV243_16350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HV243_16355	COG3108	Peptidase M15
HV243_16360	COG2989	Protein conserved in bacteria
HV243_16370	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HV243_16380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HV243_16385	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HV243_16390	COG3173	Aminoglycoside phosphotransferase
HV243_16405	COG3214	Protein conserved in bacteria
HV243_16420	COG2333	competence protein COMEC
HV243_16420	COG0658	competence protein
HV243_16425	COG0776	regulation of translation
HV243_16430	COG0539	negative regulation of cytoplasmic translation
HV243_16450	COG2323	membrane
HV243_16455	COG1944	ATP diphosphatase activity
HV243_16460	COG2116	formate transmembrane transporter activity
HV243_16465	COG1882	Formate acetyltransferase
HV243_16470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV243_16490	COG3959	Transketolase, thiamine diphosphate binding domain
HV243_16495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HV243_16500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_16510	COG1335	isochorismatase
HV243_16515	COG3302	dmso reductase anchor subunit
HV243_16520	COG0437	4 iron, 4 sulfur cluster binding
HV243_16525	COG0243	molybdopterin cofactor binding
HV243_16535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HV243_16545	COG1674	ftsk spoiiie
HV243_16545	COG1178	ABC-type Fe3 transport system permease component
HV243_16555	COG0492	ferredoxin-NADP+ reductase activity
HV243_16560	COG4988	ABC transporter
HV243_16565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HV243_16580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HV243_16585	COG0583	DNA-binding transcription factor activity
HV243_16595	COG1335	isochorismatase
HV243_16605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HV243_16615	COG1177	transmembrane transport
HV243_16620	COG1176	ABC-type spermidine putrescine transport system, permease component I
HV243_16625	COG3842	ATPase activity
HV243_16630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HV243_16670	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_16675	COG3226	Transcriptional regulator
HV243_16680	COG0738	Major facilitator superfamily
HV243_16685	COG0561	phosphatase activity
HV243_16695	COG2814	Major facilitator Superfamily
HV243_16700	COG0671	phosphoesterase, PA-phosphatase related
HV243_16705	COG1349	DNA-binding transcription factor activity
HV243_16710	COG1686	Belongs to the peptidase S11 family
HV243_16715	COG0625	glutathione transferase activity
HV243_16720	COG2133	pyrroloquinoline quinone binding
HV243_16755	COG1446	asparaginase
HV243_16765	COG0303	'Molybdopterin
HV243_16770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV243_16775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HV243_16780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV243_16785	COG1882	Formate acetyltransferase
HV243_16790	COG0561	phosphatase activity
HV243_16800	COG0488	(ABC) transporter
HV243_16805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HV243_16860	COG1376	ErfK ybiS ycfS ynhG family protein
HV243_16865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HV243_16880	COG2194	sulfuric ester hydrolase activity
HV243_16885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HV243_16900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HV243_16905	COG0765	amino acid transport
HV243_16910	COG1126	abc transporter atp-binding protein
HV243_16915	COG0668	transmembrane transport
HV243_16930	COG4774	siderophore transport
HV243_16940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HV243_16950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HV243_16955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HV243_16965	COG0513	Belongs to the DEAD box helicase family
HV243_16970	COG1309	transcriptional regulator
HV243_16980	COG1131	(ABC) transporter
HV243_16985	COG0842	Transport permease protein
HV243_16990	COG0842	Transport permease protein
HV243_17000	COG3568	Endonuclease Exonuclease Phosphatase
HV243_17005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HV243_17010	COG0392	lysyltransferase activity
HV243_17015	COG0670	Belongs to the BI1 family
HV243_17020	COG0314	molybdopterin synthase activity
HV243_17025	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HV243_17035	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV243_17060	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HV243_17100	COG1881	PFAM PEBP family protein
HV243_17130	COG4677	pectinesterase activity
HV243_17135	COG2165	general secretion pathway protein
HV243_17150	COG4796	Type ii and iii secretion system protein
HV243_17170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV243_17175	COG1459	type II secretion system
HV243_17185	COG0739	heme binding
HV243_17185	COG1196	nuclear chromosome segregation
HV243_17185	COG0741	lytic transglycosylase activity
HV243_17200	COG0561	phosphatase activity
HV243_17210	COG4149	molybdate abc transporter
HV243_17215	COG0725	ABC transporter, periplasmic molybdate-binding protein
HV243_17225	COG2005	Transcriptional regulator
HV243_17225	COG3585	molybdate ion transport
HV243_17230	COG1119	ATPase activity
HV243_17235	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HV243_17240	COG1085	galactose-1-phosphate uridylyltransferase
HV243_17250	COG2017	converts alpha-aldose to the beta-anomer
HV243_17260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HV243_17270	COG1230	cation diffusion facilitator family transporter
HV243_17275	COG3201	nicotinamide mononucleotide transporter
HV243_17310	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HV243_17315	COG2885	chlorophyll binding
HV243_17325	COG3064	Membrane
HV243_17330	COG0848	biopolymer transport protein
HV243_17335	COG0811	peptide transport
HV243_17340	COG0824	Thioesterase
HV243_17345	COG3790	cyd operon protein YbgE
HV243_17350	COG4890	Cyd operon protein YbgT
HV243_17355	COG1294	oxidase, subunit
HV243_17360	COG1271	oxidase subunit
HV243_17365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HV243_17375	COG4865	methylaspartate mutase activity
HV243_17380	COG3799	methylaspartate ammonia-lyase activity
HV243_17395	COG1301	dicarboxylic acid transport
HV243_17405	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_17405	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_17415	COG0583	DNA-binding transcription factor activity
HV243_17420	COG1648	precorrin-2 dehydrogenase activity
HV243_17420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HV243_17430	COG3395	kinase activity
HV243_17435	COG0235	Class ii aldolase
HV243_17440	COG1349	DNA-binding transcription factor activity
HV243_17445	COG3622	Belongs to the hyi family
HV243_17450	COG3246	L-lysine catabolic process to acetate
HV243_17470	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HV243_17480	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV243_17485	COG0567	Dehydrogenase, E1 component
HV243_17490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV243_17495	COG1053	succinate dehydrogenase
HV243_17500	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HV243_17505	COG2009	succinate dehydrogenase
HV243_17515	COG3180	Ammonia monooxygenase
HV243_17545	COG1984	allophanate hydrolase subunit 2
HV243_17550	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HV243_17565	COG5464	transposase or invertase
HV243_17600	COG2205	protein histidine kinase activity
HV243_17605	COG0745	RESPONSE REGULATOR receiver
HV243_17615	COG1982	Orn Lys Arg decarboxylase major
HV243_17620	COG0531	amino acid
HV243_17625	COG0033	Phosphoglucomutase
HV243_17630	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HV243_17635	COG0596	Alpha beta hydrolase
HV243_17645	COG0716	FMN binding
HV243_17655	COG0735	belongs to the Fur family
HV243_17660	COG0583	DNA-binding transcription factor activity
HV243_17665	COG1053	succinate dehydrogenase
HV243_17690	COG1609	Transcriptional regulator
HV243_17700	COG1653	transport
HV243_17710	COG1263	PTS System
HV243_17710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_17710	COG2190	(PTS) system
HV243_17720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HV243_17725	COG1846	Transcriptional regulator
HV243_17725	COG1940	carbohydrate kinase activity
HV243_17730	COG0647	UMP catabolic process
HV243_17735	COG0367	asparagine synthase
HV243_17775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HV243_17785	COG1702	phosphate starvation-inducible protein PhoH
HV243_17790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HV243_17810	COG0765	amino acid transport
HV243_17815	COG0765	amino acid transport
HV243_17820	COG1126	abc transporter atp-binding protein
HV243_17830	COG2888	peptidyl-tyrosine sulfation
HV243_17845	COG1466	dna polymerase III delta subunit
HV243_17865	COG0799	negative regulation of ribosome biogenesis
HV243_17875	COG0768	penicillin binding
HV243_17880	COG0772	Belongs to the SEDS family
HV243_17885	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV243_17890	COG1686	Belongs to the peptidase S11 family
HV243_17915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV243_17935	COG3069	C4-dicarboxylate transmembrane transporter activity
HV243_17940	COG4565	transcriptional regulatory protein
HV243_17945	COG3290	protein histidine kinase activity
HV243_17950	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HV243_17960	COG2301	Belongs to the HpcH HpaI aldolase family
HV243_17965	COG3051	citrate lyase alpha subunit
HV243_17980	COG0471	metal ion transport
HV243_17985	COG3719	Belongs to the RNase T2 family
HV243_18000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HV243_18030	COG3634	alkyl hydroperoxide reductase activity
HV243_18040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HV243_18045	COG0583	DNA-binding transcription factor activity
HV243_18050	COG3969	phosphoadenosine phosphosulfate
HV243_18055	COG1475	DNA binding
HV243_18060	COG0436	Aminotransferase
HV243_18065	COG0371	Dehydrogenase
HV243_18070	COG2879	small protein
HV243_18075	COG1966	Carbon starvation protein
HV243_18085	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_18090	COG3433	isochorismatase activity
HV243_18090	COG1535	isochorismatase
HV243_18095	COG1021	2,3-dihydroxybenzoate-AMP ligase
HV243_18100	COG1169	isochorismate synthase
HV243_18105	COG4592	Periplasmic binding protein
HV243_18115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV243_18120	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV243_18125	COG1120	ATPase activity
HV243_18130	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HV243_18135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HV243_18135	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HV243_18140	COG3251	PFAM MbtH domain protein
HV243_18145	COG2382	esterase
HV243_18150	COG4771	TonB-dependent receptor
HV243_18160	COG1879	ABC-type sugar transport system periplasmic component
HV243_18170	COG1129	ABC transporter
HV243_18175	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_18180	COG2390	Transcriptional regulator
HV243_18185	COG3959	Transketolase, thiamine diphosphate binding domain
HV243_18190	COG3958	Transketolase
HV243_18200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HV243_18235	COG2315	Protein conserved in bacteria
HV243_18245	COG0668	transmembrane transport
HV243_18265	COG2211	Major facilitator Superfamily
HV243_18270	COG1113	amino acid transport
HV243_18290	COG5001	Diguanylate cyclase
HV243_18290	COG3300	MHYT domain
HV243_18305	COG3059	membrane
HV243_18315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV243_18320	COG2207	Transcriptional regulator
HV243_18325	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV243_18330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_18335	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_18340	COG1538	Outer membrane efflux protein
HV243_18345	COG0745	RESPONSE REGULATOR receiver
HV243_18350	COG5002	protein histidine kinase activity
HV243_18370	COG0321	lipoyl(octanoyl) transferase activity
HV243_18370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV243_18375	COG0243	molybdopterin cofactor binding
HV243_18380	COG3005	denitrification pathway
HV243_18400	COG3005	denitrification pathway
HV243_18405	COG0745	RESPONSE REGULATOR receiver
HV243_18410	COG1879	ABC-type sugar transport system periplasmic component
HV243_18415	COG2205	protein histidine kinase activity
HV243_18415	COG0784	Response regulator, receiver
HV243_18415	COG2198	Histidine kinase
HV243_18480	COG2501	S4 domain
HV243_18485	COG1988	membrane-bound metal-dependent
HV243_18495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HV243_18505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HV243_18510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HV243_18520	COG2011	ABC-type metal ion transport system permease component
HV243_18530	COG1464	Belongs to the NlpA lipoprotein family
HV243_18540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HV243_18545	COG4181	ATPase activity
HV243_18550	COG2755	lipolytic protein G-D-S-L family
HV243_18555	COG0300	oxidoreductase activity
HV243_18560	COG3118	belongs to the thioredoxin family
HV243_18565	COG0390	transport system, permease component
HV243_18570	COG4619	ABC transporter
HV243_18575	COG0330	HflC and HflK could
HV243_18580	COG1585	Membrane protein implicated in regulation of membrane protease activity
HV243_18600	COG4771	TonB-dependent receptor
HV243_18605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV243_18615	COG3721	Heme iron utilization protein
HV243_18625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HV243_18640	COG3735	TraB family
HV243_18645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV243_18655	COG2223	nitrite transmembrane transporter activity
HV243_18660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HV243_18660	COG4651	solute:proton antiporter activity
HV243_18665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_18710	COG2832	Protein of unknown function (DUF454)
HV243_18715	COG3923	Primosomal replication protein n
HV243_18725	COG3264	Mechanosensitive ion channel
HV243_18725	COG1196	nuclear chromosome segregation
HV243_18730	COG1309	transcriptional regulator
HV243_18735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_18740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HV243_18755	COG0110	maltose O-acetyltransferase activity
HV243_18775	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV243_18780	COG5507	3-demethylubiquinone-9 3-methyltransferase
HV243_18785	COG2364	Membrane
HV243_18790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV243_18810	COG3695	enzyme binding
HV243_18815	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HV243_18820	COG1946	Acyl-CoA thioesterase
HV243_18825	COG0004	ammonium transporteR
HV243_18830	COG0347	Belongs to the P(II) protein family
HV243_18835	COG1132	(ABC) transporter
HV243_18840	COG1132	(ABC) transporter
HV243_18845	COG1522	sequence-specific DNA binding
HV243_18860	COG4533	DNA binding
HV243_18870	COG0824	Thioesterase
HV243_18875	COG1555	photosystem II stabilization
HV243_18880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV243_18885	COG0776	regulation of translation
HV243_18890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HV243_18910	COG0271	Belongs to the BolA IbaG family
HV243_18915	COG3056	Lipoprotein
HV243_18920	COG2223	nitrite transmembrane transporter activity
HV243_18925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HV243_18930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HV243_18935	COG1845	cytochrome c oxidase, subunit III
HV243_18940	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HV243_18965	COG2814	Major facilitator Superfamily
HV243_19000	COG0142	geranyltranstransferase activity
HV243_19010	COG0667	Aldo Keto reductase
HV243_19015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HV243_19020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HV243_19035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV243_19035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HV243_19045	COG4238	major outer membrane lipoprotein
HV243_19065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV243_19070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HV243_19075	COG1862	Preprotein translocase
HV243_19085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HV243_19095	COG0450	alkyl hydroperoxide reductase
HV243_19110	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HV243_19120	COG1335	isochorismatase
HV243_19125	COG0583	DNA-binding transcription factor activity
HV243_19130	COG0366	Alpha amylase catalytic
HV243_19145	COG5002	protein histidine kinase activity
HV243_19155	COG0420	3'-5' exonuclease activity
HV243_19160	COG0419	ATPase involved in DNA repair
HV243_19165	COG2814	Major facilitator Superfamily
HV243_19170	COG1940	carbohydrate kinase activity
HV243_19185	COG4126	flavin adenine dinucleotide binding
HV243_19205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HV243_19210	COG3706	GGDEF domain
HV243_19220	COG1785	Belongs to the alkaline phosphatase family
HV243_19235	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV243_19255	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HV243_19260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HV243_19265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV243_19275	COG0113	porphobilinogen synthase activity
HV243_19280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HV243_19285	COG1215	transferase activity, transferring glycosyl groups
HV243_19310	COG2271	Major facilitator Superfamily
HV243_19315	COG1840	ABC-type Fe3 transport system, periplasmic component
HV243_19325	COG3842	ATPase activity
HV243_19330	COG2040	homocysteine
HV243_19335	COG0833	amino acid
HV243_19340	COG2814	Major facilitator Superfamily
HV243_19375	COG1414	Transcriptional regulator
HV243_19400	COG1609	Transcriptional regulator
HV243_19425	COG2079	MmgE PrpD family protein
HV243_19430	COG0372	Belongs to the citrate synthase family
HV243_19440	COG3829	transcription factor binding
HV243_19450	COG1280	lysine exporter protein (LysE YggA)
HV243_19455	COG3706	GGDEF domain
HV243_19460	COG0348	domain, Protein
HV243_19480	COG0840	transmembrane signaling receptor activity
HV243_19495	COG3069	C4-dicarboxylate transmembrane transporter activity
HV243_19500	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV243_19510	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HV243_19515	COG0693	protein deglycase activity
HV243_19520	COG0531	amino acid
HV243_19525	COG0174	glutamine synthetase
HV243_19530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HV243_19535	COG1396	sequence-specific DNA binding
HV243_19535	COG1917	Cupin 2, conserved barrel domain protein
HV243_19540	COG1012	belongs to the aldehyde dehydrogenase family
HV243_19545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HV243_19560	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HV243_19565	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HV243_19570	COG1999	signal sequence binding
HV243_19575	COG1773	rubredoxin
HV243_19580	COG1271	oxidase subunit
HV243_19585	COG1294	oxidase, subunit
HV243_19605	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV243_19645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HV243_19655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HV243_19680	COG2195	Cleaves the N-terminal amino acid of tripeptides
HV243_19700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HV243_19705	COG1191	sigma factor activity
HV243_19730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HV243_19735	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV243_19755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HV243_19760	COG1256	bacterial-type flagellum assembly
HV243_19760	COG4786	Flagellar basal body rod
HV243_19780	COG4786	Flagellar basal body rod
HV243_19785	COG4787	bacterial-type flagellum-dependent cell motility
HV243_19800	COG1558	bacterial-type flagellum-dependent cell motility
HV243_19845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HV243_19865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HV243_19875	COG1677	Flagellar hook-basal body complex protein FliE
HV243_19900	COG1987	bacterial-type flagellum assembly
HV243_19905	COG1684	flagellar biosynthetic protein fliR
HV243_19920	COG0791	NLP P60 protein
HV243_19925	COG3034	peptidoglycan biosynthetic process
HV243_19930	COG0121	glutamine amidotransferase
HV243_19940	COG1960	acyl-CoA dehydrogenase activity
HV243_19945	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HV243_19955	COG2200	EAL domain
HV243_19970	COG3539	Fimbrial protein
HV243_19980	COG3121	Chaperone
HV243_19985	COG3188	usher protein
HV243_19995	COG3539	Fimbrial protein
HV243_20015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HV243_20025	COG2226	methyltransferase
HV243_20035	COG1388	LysM domain
HV243_20035	COG0741	lytic transglycosylase activity
HV243_20040	COG2226	methyltransferase
HV243_20050	COG2814	Major facilitator Superfamily
HV243_20055	COG0583	DNA-binding transcription factor activity
HV243_20090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HV243_20100	COG2011	ABC-type metal ion transport system permease component
HV243_20105	COG1464	Belongs to the NlpA lipoprotein family
HV243_20115	COG1720	tRNA m6t6A37 methyltransferase activity
HV243_20125	COG0791	NLP P60 protein
HV243_20130	COG3015	lipoprotein NlpE involved in copper resistance
HV243_20135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HV243_20150	COG4568	rho-dependent transcription termination
HV243_20160	COG0346	lactoylglutathione lyase activity
HV243_20200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HV243_20205	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HV243_20220	COG0575	Belongs to the CDS family
HV243_20230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HV243_20275	COG3835	regulator
HV243_20300	COG2860	membrane
HV243_20325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HV243_20330	COG1120	ATPase activity
HV243_20335	COG4774	siderophore transport
HV243_20340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HV243_20345	COG1643	Atp-dependent helicase
HV243_20350	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HV243_20370	COG0617	tRNA 3'-terminal CCA addition
HV243_20375	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HV243_20395	COG0726	polysaccharide deacetylase
HV243_20400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_20405	COG0842	Transport permease protein
HV243_20410	COG1131	(ABC) transporter
HV243_20415	COG0288	reversible hydration of carbon dioxide
HV243_20420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HV243_20425	COG4993	Dehydrogenase
HV243_20475	COG3064	Membrane
HV243_20495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HV243_20500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HV243_20505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HV243_20520	COG2211	Major facilitator Superfamily
HV243_20525	COG3940	Belongs to the glycosyl hydrolase 43 family
HV243_20530	COG3725	Membrane protein required for beta-lactamase induction
HV243_20545	COG4969	Belongs to the N-Me-Phe pilin family
HV243_20550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HV243_20555	COG1459	type II secretion system
HV243_20565	COG0237	dephospho-CoA kinase activity
HV243_20580	COG0494	nUDIX hydrolase
HV243_20600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HV243_20605	COG0849	cell division
HV243_20615	COG1181	Belongs to the D-alanine--D-alanine ligase family
HV243_20630	COG0772	Belongs to the SEDS family
HV243_20635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HV243_20645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HV243_20650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HV243_20655	COG0768	penicillin binding
HV243_20685	COG0028	Belongs to the TPP enzyme family
HV243_20720	COG2814	Major facilitator Superfamily
HV243_20740	COG1178	ABC-type Fe3 transport system permease component
HV243_20750	COG0586	Pfam SNARE associated Golgi protein
HV243_20770	COG0235	Class ii aldolase
HV243_20780	COG0417	DNA replication proofreading
HV243_20790	COG0564	pseudouridine synthase activity
HV243_20850	COG2271	Major facilitator Superfamily
HV243_20860	COG0644	oxidoreductase
HV243_20910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HV243_20915	COG0505	Belongs to the CarA family
HV243_20925	COG1609	Transcriptional regulator
HV243_20940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_20940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_20945	COG3715	PTS system
HV243_20950	COG3716	PTS system mannose fructose sorbose family IID component
HV243_20960	COG2140	Oxalate decarboxylase
HV243_20975	COG1047	Peptidyl-prolyl cis-trans
HV243_20990	COG0196	riboflavin kinase activity
HV243_21005	COG0583	DNA-binding transcription factor activity
HV243_21025	COG0641	radical SAM
HV243_21030	COG3119	arylsulfatase activity
HV243_21065	COG0443	Heat shock 70 kDa protein
HV243_21070	COG1584	GPR1 FUN34 yaaH family protein
HV243_21080	COG0521	Mo-molybdopterin cofactor biosynthetic process
HV243_21090	COG1115	amino acid carrier protein
HV243_21100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HV243_21110	COG0527	aspartate kinase activity
HV243_21110	COG0460	homoserine dehydrogenase
HV243_21120	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HV243_21130	COG0745	RESPONSE REGULATOR receiver
HV243_21135	COG4452	Inner membrane protein CreD
HV243_21140	COG2205	protein histidine kinase activity
HV243_21145	COG0745	RESPONSE REGULATOR receiver
HV243_21150	COG3045	CreA protein
HV243_21155	COG3708	Transcriptional regulator
HV243_21155	COG2207	Transcriptional regulator
HV243_21175	COG0741	lytic transglycosylase activity
HV243_21180	COG0488	(ABC) transporter
HV243_21195	COG0560	Phosphoserine phosphatase
HV243_21200	COG3726	membrane protein affecting hemolysin expression
HV243_21230	COG1328	CTP reductase activity
HV243_21235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV243_21240	COG0084	hydrolase, TatD family'
HV243_21245	COG4667	esterase of the alpha-beta hydrolase superfamily
HV243_21250	COG5487	UPF0391 membrane protein
HV243_21255	COG2823	Periplasmic or secreted lipoprotein
HV243_21265	COG1011	Hydrolase
HV243_21270	COG0456	acetyltransferase
HV243_21275	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HV243_21305	COG3706	GGDEF domain
HV243_21310	COG4114	ferric iron reductase
HV243_21315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV243_21320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HV243_21325	COG2197	response regulator
HV243_21330	COG2197	response regulator
HV243_21335	COG2966	Psort location CytoplasmicMembrane, score
HV243_21350	COG1484	DNA-dependent DNA replication
HV243_21370	COG1063	alcohol dehydrogenase
HV243_21375	COG1802	Transcriptional regulator
HV243_21380	COG2271	Major facilitator Superfamily
HV243_21390	COG0840	transmembrane signaling receptor activity
HV243_21400	COG1966	Carbon starvation protein
HV243_21405	COG2879	small protein
HV243_21410	COG0523	cobalamin synthesis protein
HV243_21430	COG1715	Restriction endonuclease
HV243_21445	COG0732	type I restriction modification DNA specificity domain
HV243_21460	COG5457	Domain of unknown function (DUF1127)
HV243_21465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HV243_21470	COG5464	transposase or invertase
HV243_21475	COG1917	Cupin 2, conserved barrel domain protein
HV243_21475	COG2207	Transcriptional regulator
HV243_21490	COG0626	cystathionine gamma-synthase activity
HV243_21495	COG1301	dicarboxylic acid transport
HV243_21500	COG0583	DNA-binding transcription factor activity
HV243_21505	COG2733	membrane
HV243_21510	COG0477	Major facilitator Superfamily
HV243_21520	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HV243_21530	COG2186	Transcriptional regulator
HV243_21535	COG0246	Mannitol dehydrogenase
HV243_21550	COG1556	Lactate utilization protein
HV243_21555	COG1139	Iron-sulfur cluster binding protein
HV243_21560	COG0247	lactate metabolic process
HV243_21565	COG1620	l-lactate permease
HV243_21625	COG2003	Belongs to the UPF0758 family
HV243_21655	COG3596	GTP binding
HV243_21660	COG2378	regulation of single-species biofilm formation
HV243_21690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV243_21695	COG1061	Type III restriction enzyme res subunit
HV243_21700	COG1002	Type II restriction enzyme, methylase subunits
HV243_21705	COG0582	viral genome integration into host DNA
HV243_21715	COG1064	alcohol dehydrogenase
HV243_21720	COG3265	gluconokinase activity
HV243_21725	COG1063	alcohol dehydrogenase
HV243_21730	COG1028	Short-chain dehydrogenase reductase Sdr
HV243_21735	COG2610	gluconate transmembrane transporter activity
HV243_21740	COG1609	Transcriptional regulator
HV243_21745	COG0433	COG0433 Predicted ATPase
HV243_21750	COG0795	lipopolysaccharide-transporting ATPase activity
HV243_21755	COG0795	lipopolysaccharide-transporting ATPase activity
HV243_21765	COG2927	DNA polymerase III (CHI subunit)
HV243_21770	COG0525	valine-tRNA ligase activity
HV243_21800	COG2731	YhcH YjgK YiaL family protein
HV243_21815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HV243_21820	COG1288	antiporter activity
HV243_21825	COG1438	arginine binding
HV243_21870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HV243_21885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HV243_21885	COG1263	PTS System
HV243_21890	COG0366	Alpha amylase catalytic
HV243_21905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_21905	COG3711	transcriptional antiterminator
HV243_21920	COG3964	amidohydrolase
HV243_21955	COG0312	modulator of DNA gyrase
HV243_21965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HV243_21975	COG1486	melibiose metabolic process
HV243_21980	COG0517	IMP dehydrogenase activity
HV243_21980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HV243_21985	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HV243_21995	COG0840	transmembrane signaling receptor activity
HV243_22000	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_22005	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_22010	COG1129	ABC transporter
HV243_22015	COG1879	ABC-type sugar transport system periplasmic component
HV243_22025	COG3391	amine dehydrogenase activity
HV243_22030	COG4771	TonB-dependent receptor
HV243_22035	COG2105	PFAM AIG2 family protein
HV243_22040	COG2911	Protein conserved in bacteria
HV243_22045	COG0729	surface antigen
HV243_22055	COG1253	flavin adenine dinucleotide binding
HV243_22065	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HV243_22070	COG1218	3'(2'),5'-bisphosphate nucleotidase
HV243_22080	COG1733	regulation of RNA biosynthetic process
HV243_22085	COG0702	epimerase
HV243_22095	COG0697	spore germination
HV243_22100	COG0840	transmembrane signaling receptor activity
HV243_22110	COG1113	amino acid transport
HV243_22115	COG0545	Peptidyl-prolyl cis-trans isomerase
HV243_22120	COG3061	Opacity-associated protein A
HV243_22135	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HV243_22150	COG0730	response to heat
HV243_22200	COG1073	alpha beta
HV243_22205	COG3650	response to hydrogen peroxide
HV243_22215	COG1960	acyl-CoA dehydrogenase activity
HV243_22220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HV243_22225	COG0557	exoribonuclease II activity
HV243_22240	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HV243_22245	COG0330	HflC and HflK could
HV243_22250	COG0330	HflC and HflK could
HV243_22255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HV243_22260	COG1923	regulation of RNA biosynthetic process
HV243_22275	COG0860	N-Acetylmuramoyl-L-alanine amidase
HV243_22280	COG0802	atpase or kinase
HV243_22285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HV243_22285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HV243_22290	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HV243_22325	COG1511	domain protein
HV243_22325	COG3264	Mechanosensitive ion channel
HV243_22340	COG1053	succinate dehydrogenase
HV243_22345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HV243_22400	COG1509	lysine 2,3-aminomutase activity
HV243_22425	COG0531	amino acid
HV243_22430	COG3030	protein affecting phage T7 exclusion by the F plasmid
HV243_22435	COG1027	Aspartate ammonia-lyase
HV243_22440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV243_22455	COG1309	transcriptional regulator
HV243_22500	COG1450	Type ii and iii secretion system protein
HV243_22570	COG3290	protein histidine kinase activity
HV243_22575	COG4565	transcriptional regulatory protein
HV243_22580	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HV243_22585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_22585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HV243_22590	COG3647	Membrane
HV243_22600	COG2211	Major facilitator Superfamily
HV243_22605	COG1486	melibiose metabolic process
HV243_22610	COG2169	Transcriptional regulator
HV243_22615	COG1982	Orn Lys Arg decarboxylase major
HV243_22620	COG2207	Transcriptional regulator
HV243_22625	COG0531	amino acid
HV243_22670	COG2824	Alkylphosphonate utilization operon protein PhnA
HV243_22675	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HV243_22680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HV243_22685	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HV243_22690	COG3639	organic phosphonate transmembrane transporter activity
HV243_22695	COG2188	Transcriptional regulator
HV243_22700	COG3624	Phosphonate C-P lyase system protein PhnG
HV243_22705	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HV243_22710	COG3626	phosphonate metabolism
HV243_22715	COG3627	carbon phosphorus lyase activity
HV243_22720	COG4107	phosphonate C-P lyase system protein PhnK
HV243_22725	COG4778	phosphonate C-P lyase system protein PhnL
HV243_22730	COG3454	Phosphonate metabolism
HV243_22735	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HV243_22740	COG0456	acetyltransferase
HV243_22745	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HV243_22760	COG1129	ABC transporter
HV243_22765	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_22790	COG0745	RESPONSE REGULATOR receiver
HV243_22800	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HV243_22805	COG1301	dicarboxylic acid transport
HV243_22810	COG4235	cytochrome complex assembly
HV243_22815	COG3088	subunit of a heme lyase
HV243_22820	COG1138	Cytochrome C-type biogenesis protein
HV243_22825	COG3301	Polysulphide reductase, NrfD
HV243_22830	COG0437	4 iron, 4 sulfur cluster binding
HV243_22835	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HV243_22850	COG3162	membrane
HV243_22865	COG0673	inositol 2-dehydrogenase activity
HV243_22870	COG1346	cytolysis
HV243_22875	COG1380	Effector of murein hydrolase LrgA
HV243_22880	COG0583	DNA-binding transcription factor activity
HV243_22885	COG0025	NhaP-type Na H and K H
HV243_22890	COG2252	PERMEase
HV243_22895	COG0789	Transcriptional regulator
HV243_22905	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HV243_22915	COG0629	single-stranded DNA binding
HV243_22920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HV243_22925	COG2315	Protein conserved in bacteria
HV243_22930	COG3700	Belongs to the class B bacterial acid phosphatase family
HV243_22935	COG1448	Aminotransferase
HV243_22945	COG0305	Participates in initiation and elongation during chromosome replication
HV243_22960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HV243_22970	COG0735	belongs to the Fur family
HV243_22975	COG3237	CsbD-like
HV243_22980	COG0534	Mate efflux family protein
HV243_22990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HV243_23005	COG3121	Chaperone
HV243_23010	COG3188	usher protein
HV243_23015	COG3539	Fimbrial protein
HV243_23045	COG2182	Extracellular solute-binding protein
HV243_23060	COG3223	Belongs to the PsiE family
HV243_23065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HV243_23070	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HV243_23095	COG0527	aspartate kinase activity
HV243_23110	COG1187	pseudouridine synthase activity
HV243_23115	COG4977	sequence-specific DNA binding
HV243_23135	COG1410	methionine synthase
HV243_23135	COG0646	methionine synthase
HV243_23155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HV243_23190	COG0151	Belongs to the GarS family
HV243_23200	COG4191	Histidine kinase
HV243_23255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HV243_23260	COG2104	thiamine diphosphate biosynthetic process
HV243_23275	COG1278	Cold shock
HV243_23285	COG1447	Phosphotransferase system cellobiose-specific component IIA
HV243_23320	COG0250	Participates in transcription elongation, termination and antitermination
HV243_23365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HV243_23425	COG0583	DNA-binding transcription factor activity
HV243_23430	COG3979	chitinase
HV243_23465	COG2207	Transcriptional regulator
HV243_23470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_23475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HV243_23480	COG1882	Formate acetyltransferase
HV243_23485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_23490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_23495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HV243_23495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_23495	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_23505	COG0371	Dehydrogenase
HV243_23515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HV243_23520	COG0583	DNA-binding transcription factor activity
HV243_23530	COG0737	Belongs to the 5'-nucleotidase family
HV243_23540	COG0460	homoserine dehydrogenase
HV243_23540	COG0527	aspartate kinase activity
HV243_23545	COG0626	cystathionine gamma-synthase activity
HV243_23555	COG2211	Major facilitator Superfamily
HV243_23570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HV243_23575	COG1609	Transcriptional regulator
HV243_23580	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HV243_23595	COG1575	Belongs to the MenA family. Type 1 subfamily
HV243_23605	COG3074	FtsZ-dependent cytokinesis
HV243_23610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HV243_23620	COG1494	fructose-1,6-bisphosphatase
HV243_23630	COG3152	Membrane
HV243_23655	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HV243_23670	COG3678	ATP-independent chaperone mediated protein folding
HV243_23675	COG0745	RESPONSE REGULATOR receiver
HV243_23680	COG2205	protein histidine kinase activity
HV243_23685	COG2271	Major facilitator Superfamily
HV243_23690	COG1082	Xylose isomerase domain protein TIM barrel
HV243_23695	COG2188	Transcriptional regulator
HV243_23700	COG2258	MOSC domain
HV243_23705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HV243_23760	COG1454	alcohol dehydrogenase
HV243_23780	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HV243_23790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_23795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_23795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HV243_23800	COG1363	Peptidase, m42
HV243_23805	COG3711	transcriptional antiterminator
HV243_23805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HV243_23825	COG0437	4 iron, 4 sulfur cluster binding
HV243_23830	COG2864	formate dehydrogenase
HV243_23845	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HV243_23855	COG4680	protein conserved in bacteria
HV243_23860	COG5499	transcription regulator containing HTH domain
HV243_23865	COG0456	acetyltransferase
HV243_23870	COG1490	D-aminoacyl-tRNA deacylase activity
HV243_23880	COG1011	Hydrolase
HV243_23890	COG0477	Major facilitator Superfamily
HV243_23900	COG1063	alcohol dehydrogenase
HV243_23905	COG3684	Belongs to the aldolase LacD family
HV243_23910	COG2084	Dehydrogenase
HV243_23915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_23920	COG1349	DNA-binding transcription factor activity
HV243_23935	COG3852	Histidine kinase
HV243_23940	COG2204	response regulator
HV243_23950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HV243_23975	COG0204	Acyl-transferase
HV243_23990	COG3084	Protein conserved in bacteria
HV243_23995	COG0746	molybdenum cofactor guanylyltransferase activity
HV243_24000	COG1763	Mo-molybdopterin cofactor biosynthetic process
HV243_24040	COG1739	Uncharacterized protein family UPF0029
HV243_24060	COG1609	Transcriptional regulator
HV243_24065	COG1940	carbohydrate kinase activity
HV243_24075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HV243_24090	COG0805	protein transport
HV243_24135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HV243_24140	COG0583	DNA-binding transcription factor activity
HV243_24145	COG0697	spore germination
HV243_24150	COG0561	phosphatase activity
HV243_24155	COG2267	carboxylic ester hydrolase activity
HV243_24160	COG1280	lysine exporter protein (LysE YggA)
HV243_24165	COG1280	lysine exporter protein (LysE YggA)
HV243_24200	COG1011	Hydrolase
HV243_24245	COG2959	enzyme of heme biosynthesis
HV243_24250	COG3071	HemY protein
HV243_24295	COG2244	polysaccharide biosynthetic process
HV243_24300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HV243_24305	COG0456	acetyltransferase
HV243_24310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HV243_24315	COG1088	dTDP-glucose 4,6-dehydratase activity
HV243_24320	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HV243_24335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HV243_24340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HV243_24350	COG3118	belongs to the thioredoxin family
HV243_24370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HV243_24390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HV243_24400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HV243_24405	COG3978	acetolactate synthase activity
HV243_24425	COG3085	chromosome segregation
HV243_24465	COG2186	Transcriptional regulator
HV243_24470	COG0477	Major facilitator Superfamily
HV243_24475	COG1609	Transcriptional regulator
HV243_24480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HV243_24485	COG1879	ABC-type sugar transport system periplasmic component
HV243_24490	COG1172	Belongs to the binding-protein-dependent transport system permease family
HV243_24500	COG1869	D-ribose catabolic process
HV243_24525	COG1522	sequence-specific DNA binding
HV243_24530	COG0716	FMN binding
HV243_24545	COG3312	ion transport
HV243_24570	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HV243_24580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HV243_24585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HV243_24600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HV243_24605	COG0573	inorganic phosphate transmembrane transporter activity
HV243_24610	COG0581	inorganic phosphate transmembrane transporter activity
HV243_24620	COG0704	Plays a role in the regulation of phosphate uptake
HV243_24625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HV243_24630	COG2252	PERMEase
HV243_24635	COG0431	NADPH-dependent FMN reductase
HV243_24640	COG2091	lysine biosynthetic process via aminoadipic acid
HV243_24675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HV243_24720	COG0431	NADPH-dependent FMN reductase
HV243_24730	COG0798	PFAM Bile acid sodium symporter
HV243_24750	COG1522	sequence-specific DNA binding
HV243_24760	COG0789	Transcriptional regulator
HV243_24780	COG1393	Belongs to the ArsC family
HV243_24840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HV243_24890	COG2205	protein histidine kinase activity
HV243_24895	COG0745	RESPONSE REGULATOR receiver
HV243_24900	COG1276	copper resistance
HV243_24905	COG2372	response to copper ion
HV243_24910	COG3667	copper resistance
HV243_24915	COG2132	Multicopper oxidase
HV243_24925	COG0739	heme binding
HV243_24955	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HV243_25135	COG1475	DNA binding