locus-tag class description CLM_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CLM_0006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CLM_0007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CLM_0016 ENOG4108Z3G 3H domain protein CLM_0033 ENOG4105C28 cystathionine CLM_0034 ENOG4108Z6B deaminase CLM_0037 ENOG4105C6E dna polymerase iii CLM_0043 ENOG4105E09 nadh pyrophosphatase CLM_0047 ENOG4105CUZ uba thif-type nad fad binding protein CLM_0049 ENOG4105D9U N-acetyltransferase CLM_0074 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CLM_0083 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CLM_0089 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CLM_0091 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CLM_0096 ENOG4105CXN decarboxylase CLM_0098 ENOG4105X0R protein from nitrogen regulatory protein P-II CLM_0099 ENOG4107XK4 dna polymerase iii subunits gamma and tau CLM_0100 ENOG4105MA4 psp1 domain protein CLM_0103 ENOG41060K3 Methyltransferase CLM_0104 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CLM_0105 ENOG4107SN7 NLP P60 protein CLM_0112 ENOG4107BJW polysaccharide deacetylase CLM_0114 ENOG4108JIC nucleoside recognition domain protein CLM_0116 ENOG4105UQX Mate efflux family protein CLM_0117 ENOG4108UN4 phage SPO1 DNA polymerase-related protein CLM_0119 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CLM_0120 ENOG4108UH6 UPF0754 membrane protein CLM_0121 ENOG4105F8V Hydrolase, tatD family CLM_0122 ENOG41069ER domain protein CLM_0129 ENOG4105C19 ABC transporter CLM_0130 ENOG4107RBB ABC transporter, permease CLM_0132 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein CLM_0135 ENOG4105BZU Histidine kinase CLM_0136 ENOG4105KT7 mgtC SapB transporter CLM_0137 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase CLM_0141 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein CLM_0142 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CLM_0145 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CLM_0146 ENOG4105C8M UPF0272 protein CLM_0148 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase CLM_0151 ENOG4108TJN glycosyl transferase group 1 CLM_0152 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) CLM_0156 ENOG4108TJN glycosyl transferase group 1 CLM_0158 ENOG4105XFA sporulation peptidase YabG CLM_0159 ENOG4105W42 Veg protein CLM_0162 ENOG4105DDG Cyanophycinase CLM_0167 ENOG4108Q8B Spore germination protein CLM_0169 ENOG4108ZXQ stage ii sporulation protein r CLM_0170 ENOG4108QBV Monogalactosyldiacylglycerol synthase CLM_0171 ENOG4105MSI germination protein ypeb CLM_0175 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CLM_0177 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CLM_0180 ENOG4105CBJ Metal-dependent enzyme CLM_0185 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CLM_0186 ENOG4107WAU Protein tyrosine phosphatase CLM_0187 ENOG4108YZG isomerase CLM_0191 ENOG4105ESV Glycosyl transferase, family 4 CLM_0192 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CLM_0194 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CLM_0203 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CLM_0206 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CLM_0208 ENOG4108ZDA Sporulation protein YyaC CLM_0209 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CLM_0217 ENOG4105C7H Helicase, RecD TraA family CLM_0226 ENOG4108SAX Membrane CLM_0231 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CLM_0235 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) CLM_0238 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CLM_0242 ENOG4105D2N Aldolase CLM_0244 ENOG4105H67 Protein of unknown function (DUF421) CLM_0245 ENOG4105C22 threonyL-tRNA synthetase CLM_0247 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CLM_0248 ENOG41080XP Cbs domain CLM_0249 ENOG4105CBD Diacylglycerol kinase CLM_0255 ENOG4105C6T cysteine synthase CLM_0256 ENOG4105D7W serine acetyltransferase CLM_0257 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CLM_0259 ENOG4105CSM endonuclease III CLM_0260 ENOG4105C6K Malic enzyme CLM_0263 ENOG4105DER m42 family CLM_0264 ENOG41073R8 VanW family CLM_0265 ENOG41073R8 VanW family CLM_0266 ENOG4105F6S Spore photoproduct lyase CLM_0267 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CLM_0268 ENOG4105EPR degv family CLM_0269 ENOG4105DIH basic membrane CLM_0270 ENOG4108JQ9 ABC transporter CLM_0271 ENOG4105UIB (ABC) transporter CLM_0273 ENOG4107VMI polysaccharide deacetylase CLM_0274 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_0282 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CLM_0287 ENOG4105DNP FAD linked oxidase domain protein CLM_0288 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CLM_0291 ENOG4105DY8 decarboxylase CLM_0295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CLM_0299 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CLM_0302 ENOG4108IQI permease CLM_0307 ENOG4105NAE bifunctional deaminase-reductase domain protein CLM_0308 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CLM_0315 ENOG4105CZ3 stage V sporulation protein ad CLM_0316 ENOG41090VF Stage v sporulation protein ac CLM_0317 ENOG4108QG2 Membrane CLM_0321 ENOG4107QIV Cytochrome c biogenesis protein CLM_0324 ENOG4105EB3 Histidine kinase CLM_0325 ENOG4105DNP FAD linked oxidase domain protein CLM_0326 ENOG4105F8D glycoside hydrolase family 4 CLM_0327 ENOG4105CI1 PTS System CLM_0328 ENOG4105HX0 Transcriptional regulator CLM_0330 ENOG4105C5Y PTS System CLM_0332 ENOG4105EWM Histidine kinase CLM_0333 ENOG4105C19 ABC transporter CLM_0335 ENOG4105CI1 PTS System CLM_0336 ENOG4105F8D glycoside hydrolase family 4 CLM_0340 ENOG4105VEQ Cold shock protein CLM_0342 ENOG4108Z40 Transcriptional regulator CLM_0343 ENOG4107ZXU DSBA oxidoreductase CLM_0344 ENOG4108RYK Nad-dependent epimerase dehydratase CLM_0345 ENOG4108Q3X Transcriptional regulator CLM_0346 ENOG4105CI1 PTS System CLM_0348 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane CLM_0349 ENOG4105C01 Dihydroxy-acid dehydratase CLM_0351 ENOG4105D7K pfkb domain protein CLM_0354 ENOG4105F3H Histidine kinase CLM_0355 ENOG4105CKK Glycosyl transferase, family 2 CLM_0357 ENOG4105EDW glycosyl transferase, family 39 CLM_0358 ENOG4105E7U AraC family transcriptional regulator CLM_0362 ENOG4105E0A ABC, transporter CLM_0367 ENOG4105DY9 regulatoR CLM_0370 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CLM_0372 ENOG4105IBP Cyclic peptide transporter CLM_0378 ENOG4108V5C ABC transporter CLM_0379 ENOG4105DQ5 transport system permease protein CLM_0380 ENOG4105EHG Permease protein CLM_0381 ENOG4105E0A ABC, transporter CLM_0382 ENOG4105BZ1 (ABC) transporter CLM_0388 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CLM_0393 ENOG41067MG lrgb family CLM_0404 ENOG4105BZU Histidine kinase CLM_0408 ENOG4105BZU Histidine kinase CLM_0409 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CLM_0410 ENOG4105CFF transcriptional regulator CLM_0411 ENOG4105E5D amino acid CLM_0412 ENOG4105DC7 peptidase M24 CLM_0420 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CLM_0421 ENOG4105BZU Histidine kinase CLM_0425 ENOG4105BZU Histidine kinase CLM_0430 ENOG4105C9B Cysteine desulfurase CLM_0431 ENOG4105HMI Membrane CLM_0434 ENOG4105BZU Histidine kinase CLM_0435 ENOG4107RUZ Sss sodium solute transporter superfamily CLM_0436 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CLM_0437 ENOG4105D6A Electron transport complex CLM_0438 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit CLM_0439 ENOG4105DZB Electron transport complex CLM_0440 ENOG4105DGN Electron transport complex CLM_0441 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit CLM_0445 ENOG4105CJ2 (LipO)protein CLM_0451 ENOG4105JFG SpoIID LytB domain protein CLM_0454 ENOG4105CVA phosphate CLM_0455 ENOG4105C8U phosphate abc transporter CLM_0457 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CLM_0459 ENOG4107QTZ amino acid CLM_0463 ENOG4108UUM single-stranded DNA-binding protein CLM_0467 ENOG4105CPI Metal Dependent Phosphohydrolase CLM_0468 ENOG4107ZXI Rhomboid family CLM_0470 ENOG4105IU0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CLM_0480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CLM_0481 ENOG4105F1K Glutamine amidotransferase CLM_0482 ENOG4105DMS mur ligase CLM_0483 ENOG4105DG6 mannose-6-phosphate isomerase CLM_0485 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CLM_0494 ENOG4105E8R UPF0173 metal-dependent hydrolase CLM_0496 ENOG4107SDT Homocitrate synthase CLM_0497 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CLM_0498 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CLM_0499 ENOG4105CDA abc transporter atp-binding protein CLM_0501 ENOG4107S6Z Na H antiporter CLM_0502 ENOG4105WG9 Conserved Protein CLM_0510 ENOG4108IG5 Transcriptional regulator CLM_0513 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CLM_0519 ENOG4105C8Q Methyl-accepting chemotaxis CLM_0524 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CLM_0527 ENOG4105E5Q amino acid AbC transporter CLM_0528 ENOG4105E89 ABC transporter CLM_0529 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CLM_0530 ENOG4105D58 Diguanylate phosphodiesterase CLM_0533 ENOG4105DWF phosphomethylpyrimidine kinase CLM_0536 ENOG4105CP9 extracellular ligand-binding receptor CLM_0537 ENOG4105C32 Amino acid ABC transporter (Permease) CLM_0538 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CLM_0539 ENOG4105C0Z ABC transporter CLM_0540 ENOG4108IV0 ABC, transporter CLM_0547 ENOG4105HA9 of methanol dehydrogenase type CLM_0551 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CLM_0552 ENOG4105VMP Transcriptional regulator CLM_0556 ENOG4105EYH Exonuclease CLM_0561 ENOG4105C59 p-type ATPase CLM_0569 ENOG4108IAB Phoh family CLM_0570 ENOG4108HQ0 Exopolysaccharide biosynthesis protein CLM_0578 ENOG4105CJ1 ABC, transporter CLM_0582 ENOG4108Z4T Peptidase M50 CLM_0584 ENOG4105WH1 Two component transcriptional regulator luxr family CLM_0585 ENOG4105CJ1 ABC, transporter CLM_0587 ENOG4108KYE ABC-2 type transporter CLM_0593 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CLM_0594 ENOG4105CHR reductase CLM_0597 ENOG4105E5G Alpha beta hydrolase fold CLM_0598 ENOG4105XJC Two component transcriptional regulator (Winged helix family CLM_0599 ENOG4105CPI Metal Dependent Phosphohydrolase CLM_0600 ENOG4105C8Q Methyl-accepting chemotaxis CLM_0601 ENOG410812K response regulator receiver protein CLM_0602 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CLM_0603 ENOG4105DVT helicase CLM_0609 ENOG410828M hemerythrin-like, metal-binding protein CLM_0619 ENOG4105BZ1 (ABC) transporter CLM_0622 ENOG4105C19 ABC transporter CLM_0625 ENOG4105C0X amino acid CLM_0627 ENOG4108VVK transcriptional Regulator, AsnC CLM_0629 ENOG4105D5Q Arginine ornithine antiporter CLM_0630 ENOG4105D5Q Arginine ornithine antiporter CLM_0631 ENOG4108Z0R Transferase CLM_0632 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 CLM_0635 ENOG4105CAH Chromate CLM_0636 ENOG4105FGV Chromate CLM_0637 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CLM_0639 ENOG4108DWA Nad synthetase CLM_0643 ENOG4107RAQ aminopeptidase CLM_0652 ENOG4105D22 carbon starvation protein CLM_0655 ENOG4105C5H ABC transporter CLM_0656 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CLM_0660 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CLM_0661 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CLM_0662 ENOG4105CZV ABC transporter CLM_0665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CLM_0666 ENOG4105F38 ABC transporter, permease CLM_0667 ENOG4105D38 putrescine abc transporter CLM_0670 ENOG4107QJT sodium dicarboxylate symporter CLM_0680 ENOG4105DDN Pentapeptide repeat-containing protein CLM_0686 ENOG4105DY9 regulatoR CLM_0694 ENOG4105BZ1 (ABC) transporter CLM_0698 ENOG4105C19 ABC transporter CLM_0700 ENOG4105EPR degv family CLM_0703 ENOG4105E0M Sulfatase CLM_0705 ENOG4105D9N nucleoside CLM_0709 ENOG41086D8 Transcriptional regulator CLM_0714 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_0715 ENOG4105C08 Histidine kinase CLM_0717 ENOG4108VXD carboxy-peptidase CLM_0719 ENOG4105BZU Histidine kinase CLM_0722 ENOG4105BZU Histidine kinase CLM_0723 ENOG4105CNI cell division protein FtsW CLM_0726 ENOG4105BZ1 (ABC) transporter CLM_0728 ENOG41062JF Transcriptional regulator CLM_0730 ENOG4108Z7R Chaperone CsaA CLM_0731 ENOG4105CF7 AraC family transcriptional regulator CLM_0732 ENOG4108IMY Transcriptional regulator CLM_0734 ENOG4105DY9 regulatoR CLM_0737 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CLM_0739 ENOG4105C98 muts2 protein CLM_0743 ENOG4105WD1 Membrane CLM_0747 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CLM_0749 ENOG4105C1J atp-dependent rna helicase CLM_0752 ENOG4105C0R drug resistance transporter emrb qaca subfamily CLM_0758 ENOG4108UB4 uncharacterized protein ygjQ CLM_0761 ENOG4105M6F mutator MutT protein CLM_0764 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CLM_0767 ENOG4105CID antiterminator CLM_0768 ENOG4105C5Y PTS System CLM_0769 ENOG4105DB7 PHP domain protein CLM_0771 ENOG4105IJJ transcriptional regulator, crp fnr family CLM_0773 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CLM_0776 ENOG4105D6U Sodium Glutamate Symporter CLM_0781 ENOG4105C7J ABC transporter, permease CLM_0782 ENOG4108JJB ABC transporter CLM_0789 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CLM_0790 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CLM_0795 ENOG4107SCJ type I restriction enzyme EcoKI subunit R CLM_0797 ENOG4105FTQ Dna gyrase CLM_0799 ENOG4105NA0 Transcriptional regulator CLM_0800 ENOG4105CCN Peptidase M56 CLM_0804 ENOG4105DQ5 transport system permease protein CLM_0805 ENOG4105EHG Permease protein CLM_0806 ENOG4105E0A ABC, transporter CLM_0808 ENOG4105D0B Nitrogenase protein alpha chain CLM_0810 ENOG4105C8Q Methyl-accepting chemotaxis CLM_0817 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CLM_0818 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CLM_0820 ENOG4105DF9 Lipoate-protein, ligase CLM_0825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_0826 ENOG4105BZU Histidine kinase CLM_0827 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CLM_0834 ENOG4105W1Y Transcriptional regulator CLM_0842 ENOG41075H3 AraC family transcriptional regulator CLM_0846 ENOG4105VZ8 Transcriptional regulator CLM_0849 ENOG4105W1Y Transcriptional regulator CLM_0852 ENOG4105EEM helicase CLM_0854 ENOG41086D8 Transcriptional regulator CLM_0856 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CLM_0857 ENOG4108N3W hemolysin secretion protein CLM_0860 ENOG4105C5H ABC transporter CLM_0867 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CLM_0868 ENOG4105C28 cystathionine CLM_0869 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CLM_0872 ENOG4108I0C methyltransferase CLM_0874 ENOG41086D8 Transcriptional regulator CLM_0909 ENOG4105D6J arsenicaL-resistance protein CLM_0912 ENOG41089UC methyltransferase, type 11 CLM_0915 ENOG4105CJ1 ABC, transporter CLM_0921 ENOG4105DWF phosphomethylpyrimidine kinase CLM_0924 ENOG4105CJ1 ABC, transporter CLM_0926 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CLM_0929 ENOG41086D8 Transcriptional regulator CLM_0933 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CLM_0936 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_0937 ENOG4105BZU Histidine kinase CLM_0942 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CLM_0943 ENOG4105KHC sulfurtransferase CLM_0949 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CLM_0950 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase CLM_0953 ENOG4105CI2 imidazolone-5-propionate hydrolase CLM_0956 ENOG4105C8Q Methyl-accepting chemotaxis CLM_0958 ENOG4105CE1 Ferrous iron transport protein b CLM_0959 ENOG4105CE1 Ferrous iron transport protein b CLM_0961 ENOG4105CVJ phosphoglycerate mutase CLM_0962 ENOG41073R8 VanW family CLM_0969 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CLM_0970 ENOG4105EEI dihydropteroate synthase CLM_0973 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CLM_0974 ENOG4107Y70 Heat shock protein CLM_0975 ENOG4107SWG transcriptional regulator MERR family CLM_0976 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CLM_0979 ENOG4105JVQ RNA Polymerase CLM_0984 ENOG4105CJ1 ABC, transporter CLM_0986 ENOG41067QW Transcriptional regulator CLM_0988 ENOG4107S9D Alpha beta hydrolase CLM_0997 ENOG4105RHY Pfam:UPF0157 CLM_1000 ENOG4105KVH Transcriptional regulator CLM_1001 ENOG4108TVJ Nitroreductase CLM_1003 ENOG4105F0F Oxalate decarboxylase CLM_1004 ENOG4108URH decarboxylase CLM_1007 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CLM_1011 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CLM_1012 ENOG4108TVJ Nitroreductase CLM_1013 ENOG4105KVH Transcriptional regulator CLM_1017 ENOG41086D8 Transcriptional regulator CLM_1020 ENOG4105C5Y PTS System CLM_1021 ENOG4105CS2 ec 3.2.1.21 CLM_1023 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CLM_1038 ENOG4105T2N Domain of unknown function (DUF2382) CLM_1039 ENOG4108MTT Glutamate-rich protein grpB CLM_1040 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CLM_1048 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CLM_1050 ENOG4105BZU Histidine kinase CLM_1051 ENOG4105CM2 brancheD-chain amino acid aminotransferase CLM_1052 ENOG4107ZYJ bioY protein CLM_1054 ENOG4108MK9 spermidine N(1)-acetyltransferase CLM_1055 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CLM_1058 ENOG4107TXC Transcriptional regulator CLM_1062 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CLM_1063 ENOG4105CIH Imidazole acetol-phosphate transaminase CLM_1064 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CLM_1067 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CLM_1071 ENOG4105D52 delta-aminolevulinic acid dehydratase CLM_1072 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CLM_1073 ENOG41081F0 Precorrin-8x methylmutase CLM_1077 ENOG4105C5X domain protein CLM_1079 ENOG4105VEV -acetyltransferase CLM_1081 ENOG4107Y03 Nitroreductase CLM_1085 ENOG4105RHY Pfam:UPF0157 CLM_1090 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase CLM_1097 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CLM_1098 ENOG4105CIA precorrin-4 C(11)-methyltransferase CLM_1099 ENOG4108P62 biosynthesis protein (CbiG) CLM_1100 ENOG4105E4R Precorrin-3B C17-methyltransferase CLM_1101 ENOG4108JTQ reductase CLM_1103 ENOG4107PPM cobalt chelatase CLM_1104 ENOG4105JZC GHMP kinase CLM_1105 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CLM_1107 ENOG4107V9H nitrite transporter CLM_1108 ENOG4105D5B Sulfite reductase, subunit A CLM_1109 ENOG4107SHJ sulfite reductase subunit b CLM_1110 ENOG410810Y Sulfite reductase CLM_1116 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CLM_1118 ENOG4105E0A ABC, transporter CLM_1119 ENOG4105EHG Permease protein CLM_1120 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CLM_1123 ENOG4105PAD Hydrolase CLM_1126 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CLM_1131 ENOG4105CMT Dihydroxyacetone kinase CLM_1133 ENOG4105FTV AraC Family Transcriptional Regulator CLM_1134 ENOG4108HYG acetyltransferase CLM_1144 ENOG4107SN7 NLP P60 protein CLM_1150 ENOG4105C9U ATP-dependent DNA helicase RecQ CLM_1151 ENOG4105KY8 Rubrerythrin CLM_1152 ENOG4108RE9 Phosphodiesterase CLM_1153 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_1157 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) CLM_1161 ENOG4105QUH Domain of unknown function (DUF2088) CLM_1162 ENOG4105BZJ Electron transfer flavoprotein CLM_1163 ENOG4105C10 Electron transfer flavoprotein CLM_1164 ENOG4105CQB FAD linked oxidase domain protein CLM_1169 ENOG4105CHM Aminotransferase CLM_1171 ENOG4108INS Transcriptional regulator CLM_1172 ENOG4108Z5V transcriptional regulator, merr family CLM_1174 ENOG4105C5S asparaginyl-tRNA synthetase CLM_1179 ENOG4105PAD Hydrolase CLM_1182 ENOG4107V2S Transcriptional regulator CLM_1183 ENOG4105EPI acetyltransferase, (GNAT) family CLM_1185 ENOG4105CE1 Ferrous iron transport protein b CLM_1189 ENOG4108VXD carboxy-peptidase CLM_1192 ENOG4105BZU Histidine kinase CLM_1194 ENOG4107E6A Cytochrome p-450 CLM_1197 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CLM_1198 ENOG4105BZU Histidine kinase CLM_1200 ENOG4105E7U AraC family transcriptional regulator CLM_1201 ENOG4105DHS permease protein CLM_1202 ENOG4105CM4 permease protein CLM_1203 ENOG4108IPW abc transporter atp-binding protein CLM_1205 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions CLM_1206 ENOG4105BZ1 (ABC) transporter CLM_1207 ENOG4105BZ1 (ABC) transporter CLM_1209 ENOG4105DY9 regulatoR CLM_1215 ENOG4105C7Z Conserved Protein CLM_1216 ENOG4108QEG Membrane CLM_1224 ENOG4105C5H ABC transporter CLM_1231 ENOG4105CXY transporter CLM_1233 ENOG4105CHM Aminotransferase CLM_1236 ENOG4105CE1 Ferrous iron transport protein b CLM_1240 ENOG4108NNZ chitinase CLM_1243 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CLM_1244 ENOG4108UMI ABC transporter, permease CLM_1245 ENOG4105D01 (LipO)protein CLM_1246 ENOG4105D01 (LipO)protein CLM_1249 ENOG4105JXH GntR family transcriptional regulator CLM_1254 ENOG4105CY0 Metallo-Beta-Lactamase CLM_1256 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CLM_1257 ENOG4105C26 Dehydrogenase CLM_1260 ENOG4108U05 Transcriptional regulator CLM_1261 ENOG4105C3S Mate efflux family protein CLM_1264 ENOG4105VNH ABC transporter solute-binding protein CLM_1267 ENOG4105F38 ABC transporter, permease CLM_1268 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CLM_1273 ENOG4105DWU Membrane CLM_1274 ENOG4108UW5 maltose o-acetyltransferase CLM_1278 ENOG4105BZU Histidine kinase CLM_1281 ENOG4105CJW magnesium transporter CLM_1283 ENOG4108JQ1 Dehydrogenase CLM_1285 ENOG4105CNW domain protein CLM_1287 ENOG4105C94 Transporter CLM_1290 ENOG4108RWI nicotinamidase CLM_1291 ENOG4105C72 UPF0176 protein CLM_1297 ENOG4107RM6 sulfurtransferase CLM_1299 ENOG4105C02 permease CLM_1306 ENOG4107RCV ABC transporter, permease CLM_1307 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CLM_1310 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CLM_1311 ENOG41082UD thioesterase Superfamily protein CLM_1314 ENOG4105C7J ABC transporter, permease CLM_1315 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CLM_1317 ENOG4105CEB Aspartate aminotransferase CLM_1318 ENOG4108IPJ Membrane CLM_1319 ENOG4105DD7 kinase (PfkB family CLM_1321 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CLM_1322 ENOG410908R Methenyltetrahydrofolate cyclohydrolase CLM_1324 ENOG4105DQF Hydrolase CLM_1330 ENOG4105C6T cysteine synthase CLM_1331 ENOG4105E5Q amino acid AbC transporter CLM_1332 ENOG4105EAB amino acid AbC transporter CLM_1338 ENOG4108WCX response regulator CLM_1343 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CLM_1354 ENOG4105DKQ ROK family CLM_1358 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CLM_1360 ENOG4105DVE abc transporter atp-binding protein CLM_1368 ENOG4105BZU Histidine kinase CLM_1370 ENOG4105EJQ L-serine dehydratase CLM_1375 ENOG4108U5J '-nucleotidase CLM_1376 ENOG4108IGT Dipeptidase CLM_1378 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CLM_1380 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CLM_1381 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CLM_1386 ENOG4105WEF catalase CLM_1387 ENOG4108HQ0 Exopolysaccharide biosynthesis protein CLM_1391 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CLM_1398 ENOG4108IG5 Transcriptional regulator CLM_1406 ENOG41067QW Transcriptional regulator CLM_1411 ENOG4105C26 Dehydrogenase CLM_1415 ENOG4105EZ5 reductase CLM_1426 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CLM_1429 ENOG4105FB2 class II Aldolase CLM_1430 ENOG4105E98 transcriptional regulator DeoR family CLM_1433 ENOG4108QY0 Membrane CLM_1444 ENOG4105C7W Xanthine dehydrogenase CLM_1445 ENOG4108HR6 Dehydrogenase CLM_1446 ENOG4108UTP (2Fe-2S)-binding domain protein CLM_1447 ENOG4107Y2X deaminase CLM_1448 ENOG4105C9U ATP-dependent DNA helicase RecQ CLM_1453 ENOG4105CN5 Metallo-Beta-Lactamase CLM_1454 ENOG4105BZG amino acid carrier protein CLM_1456 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CLM_1457 ENOG4107R8N Glycosyl transferase, family 2 CLM_1463 ENOG4105C59 p-type ATPase CLM_1465 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CLM_1466 ENOG4105BZ1 (ABC) transporter CLM_1470 ENOG4105BZU Histidine kinase CLM_1493 ENOG4105C1A potassium transporter peripheral membrane CLM_1494 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) CLM_1495 ENOG4105C4R Atp-dependent dna helicase CLM_1495 ENOG4105C4R Atp-dependent dna helicase CLM_1497 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CLM_1501 ENOG4105JFG SpoIID LytB domain protein CLM_1503 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CLM_1506 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit CLM_1510 ENOG4105BZ1 (ABC) transporter CLM_1511 ENOG4105VXR cytoplasmic protein CLM_1512 ENOG4108W3Y Transcriptional regulator, Crp Fnr family CLM_1515 ENOG4105EHG Permease protein CLM_1516 ENOG4105E0A ABC, transporter CLM_1518 ENOG4105WCA Ferredoxin CLM_1519 ENOG4106KNT transcriptional regulator CLM_1529 ENOG4105EC8 Methyl-accepting chemotaxis CLM_1532 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CLM_1533 ENOG4108RZA ABC transporter CLM_1534 ENOG4108JQ7 (ABC) transporter CLM_1536 ENOG4105FAV ABC, transporter CLM_1537 ENOG4105FDK ABC transporter CLM_1538 ENOG4105DSE periplasmic solute binding protein CLM_1541 ENOG4105BZU Histidine kinase CLM_1544 ENOG4105D7T ABC transporter CLM_1545 ENOG4105G5W regulator Fur family CLM_1549 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CLM_1550 ENOG4107R7I amino acid CLM_1551 ENOG4105KWG Pfam:DUF1696 CLM_1552 ENOG4105BZU Histidine kinase CLM_1553 ENOG4105WH1 Two component transcriptional regulator luxr family CLM_1554 ENOG4105CJ1 ABC, transporter CLM_1561 ENOG4105VEQ Cold shock protein CLM_1562 ENOG4105CIN aminoacyl-histidine dipeptidase CLM_1565 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CLM_1572 ENOG4108HVR ABC transporter, permease CLM_1576 ENOG4105C87 Aminotransferase class I and II CLM_1577 ENOG4105EAB amino acid AbC transporter CLM_1578 ENOG4105E5Q amino acid AbC transporter CLM_1581 ENOG4105DZ1 carboxypeptidase CLM_1582 ENOG4105M6F mutator MutT protein CLM_1584 ENOG4107QW4 alcohol dehydrogenase CLM_1586 ENOG4105CSX c4-dicarboxylate anaerobic carrier CLM_1587 ENOG4105DAP Nicotinate phosphoribosyltransferase CLM_1588 ENOG4105CT1 (ABC) transporter CLM_1589 ENOG4105E5Q amino acid AbC transporter CLM_1593 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CLM_1594 ENOG4105CH2 amidohydrolase CLM_1595 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CLM_1596 ENOG4105C34 Pseudouridine synthase CLM_1602 ENOG4105DAN ATP-dependent protease CLM_1607 ENOG4105D4Y metalloprotease CLM_1610 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CLM_1614 ENOG4107R08 Integrase CLM_1619 ENOG4108ZUE Phage regulatory protein rha CLM_1675 ENOG41066EA baseplate J family protein CLM_1688 ENOG4108UT2 hemolysin iii CLM_1689 ENOG4105C3G gtp-binding protein CLM_1690 ENOG4108V6E Cell division protein mraZ CLM_1693 ENOG4105CJN penicillin-binding protein CLM_1695 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CLM_1697 ENOG4105CNI cell division protein FtsW CLM_1700 ENOG4105K67 small basic protein CLM_1702 ENOG4105DFA alanine racemase domain protein CLM_1704 ENOG4108VIA integral membrane protein CLM_1706 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) CLM_1707 ENOG4105D49 3-dehydroquinate synthase CLM_1708 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CLM_1709 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CLM_1710 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CLM_1712 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CLM_1713 ENOG4105C34 Pseudouridine synthase CLM_1715 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CLM_1718 ENOG4105CGK Exodeoxyribonuclease III CLM_1719 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CLM_1721 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CLM_1722 ENOG4105E0C molybdate abc transporter CLM_1723 ENOG4108IJ6 ABC transporter CLM_1727 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CLM_1728 ENOG4105DFD Na H antiporter CLM_1730 ENOG4105CKI cobalamin synthesis protein CLM_1732 ENOG4108Q52 Methyltransferase cognate corrinoid protein CLM_1733 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CLM_1735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CLM_1736 ENOG4108UMI ABC transporter, permease CLM_1737 ENOG4105D01 (LipO)protein CLM_1739 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CLM_1740 ENOG4105CU9 asparagine synthetase A CLM_1742 ENOG4105C9U ATP-dependent DNA helicase RecQ CLM_1743 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CLM_1744 ENOG4105CPC Aldo Keto reductase CLM_1745 ENOG4108ZQX ybak prolyl-trna synthetase CLM_1748 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) CLM_1750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CLM_1752 ENOG4105DRS transport system, permease CLM_1755 ENOG4105JXH GntR family transcriptional regulator CLM_1759 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CLM_1761 ENOG4105C8Q Methyl-accepting chemotaxis CLM_1764 ENOG4105KVH Transcriptional regulator CLM_1766 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CLM_1768 ENOG4105EQN UPF0261 protein CLM_1777 ENOG4108HU6 Metal dependent phosphohydrolase CLM_1780 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CLM_1788 ENOG4105WH1 Two component transcriptional regulator luxr family CLM_1791 ENOG4105D29 Helix-turn-helix type 11 domain protein CLM_1794 ENOG4105CIZ coA-substrate-specific enzyme activase CLM_1795 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase CLM_1796 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CLM_1800 ENOG4107SDU Methyl-accepting chemotaxis CLM_1803 ENOG4107RHR regulatoR CLM_1805 ENOG4108RVA ribokinase CLM_1808 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CLM_1810 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CLM_1816 ENOG4105CUC YeeE YedE family protein CLM_1818 ENOG41066VF YeeE YedE family protein CLM_1819 ENOG4105DUM transcriptional regulator, lysR family CLM_1821 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CLM_1822 ENOG4105CUC YeeE YedE family protein CLM_1823 ENOG4105DA5 (ABC) transporter CLM_1828 ENOG4105CEU Arginine dihydrolase CLM_1830 ENOG4108UT2 hemolysin iii CLM_1841 ENOG410874W AraC family transcriptional regulator CLM_1842 ENOG4105BZ1 (ABC) transporter CLM_1843 ENOG4105BZ1 (ABC) transporter CLM_1844 ENOG4105FKQ transcriptional regulator CLM_1845 ENOG4105E2R ROK family CLM_1847 ENOG4105CI1 PTS System CLM_1850 ENOG4105EGD dinuclear metal center protein, YbgI family CLM_1857 ENOG410667J hydrolase CLM_1858 ENOG4105E98 transcriptional regulator DeoR family CLM_1863 ENOG4105SYT Methylenetetrahydrofolate reductase CLM_1871 ENOG4107RUY (E1 component), alpha subunit CLM_1873 ENOG4106Z86 ATP-nad acox kinase CLM_1874 ENOG4105C7S Dehydrogenase CLM_1876 ENOG4105DF9 Lipoate-protein, ligase CLM_1878 ENOG4105E90 ABC transporter CLM_1879 ENOG4107QID Threonine synthase CLM_1881 ENOG4105CFH Aspartokinase CLM_1882 ENOG4105D6E homoserine dehydrogenase CLM_1885 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein CLM_1886 ENOG4105BZ8 glutamate synthase CLM_1889 ENOG4108J53 cell adhesion domain-containing protein CLM_1897 ENOG4108JUA Transcriptional regulator CLM_1900 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CLM_1901 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CLM_1905 ENOG4105C8Q Methyl-accepting chemotaxis CLM_1912 ENOG4108J59 Extracellular solute-binding protein, family 5 CLM_1913 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CLM_1914 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CLM_1916 ENOG4105DVT helicase CLM_1917 ENOG4105PTM secreted protein CLM_1919 ENOG4107Y70 Heat shock protein CLM_1920 ENOG4107RDB Major Facilitator CLM_1921 ENOG4105KBX Transcriptional regulator, TetR family CLM_1923 ENOG4105DE4 1-phosphofructokinase CLM_1924 ENOG4105DUX Transporter CLM_1929 ENOG4105DD7 kinase (PfkB family CLM_1930 ENOG4105K4I Scp-like extracellular CLM_1933 ENOG4105C5H ABC transporter CLM_1934 ENOG410810Y Sulfite reductase CLM_1935 ENOG4107R88 Chemotaxis protein (CheV) CLM_1937 ENOG4105QNR S1 RNA binding domain protein CLM_1938 ENOG4105C1J atp-dependent rna helicase CLM_1941 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CLM_1942 ENOG41090A1 ferritin CLM_1943 ENOG4107YTP response regulator receiver protein CLM_1945 ENOG4105DWD nucleoside recognition domain protein CLM_1950 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CLM_1953 ENOG4105CXI aluminum resistance protein CLM_1959 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CLM_1961 ENOG4105CHM Aminotransferase CLM_1964 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CLM_1967 ENOG4105CBX hi0933 family CLM_1968 ENOG4105D82 Glutamate dehydrogenase CLM_1969 ENOG4106G6Q Transcriptional regulator CLM_1970 ENOG4105FE9 pseudouridine synthase CLM_1975 ENOG4105C8Q Methyl-accepting chemotaxis CLM_1976 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CLM_1984 ENOG4108115 UPF0145 protein CLM_1986 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD CLM_1990 ENOG4105C45 hydrogenase expression formation protein (HypE) CLM_1991 ENOG4105CQS hydrogenase expression formation protein HypD CLM_1992 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF CLM_1997 ENOG4105DPX Hydrogenase, large subunit CLM_1998 ENOG4105E3S small subunit CLM_2006 ENOG4105C5H ABC transporter CLM_2007 ENOG4107QHI -hydrogenase CLM_2008 ENOG4107QIZ NADH dehydrogenase CLM_2009 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit CLM_2013 ENOG4105DZ1 carboxypeptidase CLM_2015 ENOG4105KBJ sporulation protein ytfj CLM_2017 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CLM_2020 ENOG4105DZ1 carboxypeptidase CLM_2024 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CLM_2025 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CLM_2026 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CLM_2031 ENOG4107SC7 Inner membrane transporter yjeM CLM_2087 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CLM_2088 ENOG4107QQR Sporulation CLM_2089 ENOG4105S1Z Stage IV sporulation protein B CLM_2090 ENOG4105CVG Homoserine O-transsuccinylase CLM_2091 ENOG4105D6E homoserine dehydrogenase CLM_2094 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CLM_2097 ENOG4105DX0 Hemolysin A CLM_2109 ENOG4105KQ4 Stage iii sporulation protein ad CLM_2110 ENOG4108CQH stage III sporulation protein AC CLM_2112 ENOG4105CD2 stage iii sporulation protein aa CLM_2124 ENOG4108VAU general secretion pathway protein G CLM_2125 ENOG4105D7Q type ii secretion system CLM_2126 ENOG4107QHF type ii secretion system protein e CLM_2130 ENOG4105F23 Fibronectin-binding protein CLM_2134 ENOG4105CVK Glutamate decarboxylase CLM_2136 ENOG4105C8Q Methyl-accepting chemotaxis CLM_2140 ENOG4105BZU Histidine kinase CLM_2142 ENOG4105BZU Histidine kinase CLM_2146 ENOG4105CJ1 ABC, transporter CLM_2148 ENOG4105BZ1 (ABC) transporter CLM_2153 ENOG4105WE2 aldehyde ferredoxin oxidoreductase CLM_2156 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CLM_2158 ENOG4105CVM Molybdenum cofactor synthesis domain protein CLM_2159 ENOG4105CVM Molybdenum cofactor synthesis domain protein CLM_2160 ENOG4108RIR Molybdenum cofactor biosynthesis protein CLM_2164 ENOG4105UQX Mate efflux family protein CLM_2168 ENOG4107WD8 ABC transporter, permease CLM_2170 ENOG4105BZ1 (ABC) transporter CLM_2172 ENOG41090E6 transcriptional regulator MERR family CLM_2178 ENOG41063VX Inherit from COG: glutaredoxin-related protein CLM_2179 ENOG4105KME endoribonuclease L-psp CLM_2181 ENOG4105C87 Aminotransferase class I and II CLM_2185 ENOG4105BZU Histidine kinase CLM_2186 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_2188 ENOG4108W7F transporter, permease CLM_2189 ENOG4108JJB ABC transporter CLM_2191 ENOG4106M28 alanine racemase domain protein CLM_2192 ENOG4108B31 Spore germination protein CLM_2193 ENOG4105E1K spore germination protein CLM_2201 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CLM_2203 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CLM_2204 ENOG4105C5Y PTS System CLM_2205 ENOG4105CG3 alpha amylase, catalytic region CLM_2206 ENOG4107414 GntR family transcriptional regulator CLM_2207 ENOG4105DM4 PTS System CLM_2208 ENOG4105DM4 PTS System CLM_2209 ENOG4106VEM tagatose-6-phosphate kinase CLM_2210 ENOG4105D2N Aldolase CLM_2212 ENOG4105G7B Protein of unknown function (DUF2992) CLM_2217 ENOG4105C8Q Methyl-accepting chemotaxis CLM_2219 ENOG4106M28 alanine racemase domain protein CLM_2221 ENOG4105D9R oxidoreductase CLM_2222 ENOG4107QV3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CLM_2225 ENOG4105BZU Histidine kinase CLM_2227 ENOG4108JUB Transcriptional regulator CLM_2228 ENOG4105C1J atp-dependent rna helicase CLM_2229 ENOG4105K4I Scp-like extracellular CLM_2231 ENOG4105SX7 Transporter CLM_2232 ENOG4105CHM Aminotransferase CLM_2233 ENOG4105CDA abc transporter atp-binding protein CLM_2235 ENOG4108HW3 (ABC) transporter CLM_2236 ENOG4105QUH Domain of unknown function (DUF2088) CLM_2237 ENOG4105C5R Aminotransferase CLM_2243 ENOG4105DUX Transporter CLM_2244 ENOG4105DUX Transporter CLM_2245 ENOG4105DC7 peptidase M24 CLM_2248 ENOG4105C8J )-transporter CLM_2249 ENOG4107U9B transcriptional regulator CLM_2250 ENOG4105JAB phenazine biosynthesis protein, phzf family CLM_2257 ENOG4105CCI Myosin-Cross-Reactive Antigen CLM_2262 ENOG4108N3W hemolysin secretion protein CLM_2268 ENOG4105D7W serine acetyltransferase CLM_2271 ENOG4107V9E glucose-1-phosphate thymidylyltransferase CLM_2279 ENOG41087PP glycosyltransferase MGT family CLM_2290 ENOG4105XSJ toxin secretion phage lysis holin CLM_2293 ENOG4105VEM Conserved domain protein CLM_2296 ENOG4105CVR type I restriction-modification system CLM_2298 ENOG4107UNZ domain protein CLM_2304 ENOG4105C1B dTDP-glucose 4-6-dehydratase CLM_2306 ENOG4107S6X Glycosyl transferase, family 2 CLM_2314 ENOG4105KNY Microcompartments protein CLM_2315 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) CLM_2316 ENOG4108EKI Dehydrogenase CLM_2317 ENOG4105KNY Microcompartments protein CLM_2318 ENOG4105NDK ethanolamine utilization protein CLM_2321 ENOG4107RWI ethanolamine utilization protein eutJ CLM_2323 ENOG4105KTW ethanolamine utilization protein CLM_2324 ENOG4105M3W utilization protein CLM_2325 ENOG4105F1A Pyruvate formate-lyase CLM_2326 ENOG4105C6N Formate acetyltransferase CLM_2327 ENOG4108EKI Dehydrogenase CLM_2328 ENOG4105KNY Microcompartments protein CLM_2329 ENOG4105KNY Microcompartments protein CLM_2332 ENOG4107TXC Transcriptional regulator CLM_2335 ENOG4105DJ2 Major Facilitator Superfamily CLM_2336 ENOG41073TP transcriptional regulator CLM_2341 ENOG4108XI2 Domain of unknown function (DUF1963) CLM_2347 ENOG4105CJZ response regulator CLM_2353 ENOG4105VMP Transcriptional regulator CLM_2355 ENOG4105CPQ Dehydrogenase CLM_2359 ENOG4105C19 ABC transporter CLM_2364 ENOG4106ETB IIa component CLM_2365 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CLM_2369 ENOG4108UW5 maltose o-acetyltransferase CLM_2372 ENOG4105DUX Transporter CLM_2373 ENOG4108D32 Methyltransferase CLM_2374 ENOG41086D8 Transcriptional regulator CLM_2385 ENOG4108IMY Transcriptional regulator CLM_2387 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CLM_2391 ENOG4107R7I amino acid CLM_2393 ENOG4105CIZ coA-substrate-specific enzyme activase CLM_2395 ENOG4105C10 Electron transfer flavoprotein CLM_2396 ENOG4105BZJ Electron transfer flavoprotein CLM_2397 ENOG4105C1G acyl-Coa dehydrogenase CLM_2398 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase CLM_2399 ENOG4105CMH dehydratase CLM_2404 ENOG4105FKZ Methyl-accepting chemotaxis CLM_2407 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CLM_2408 ENOG4105C6Z Gluconate CLM_2410 ENOG4105G63 Type III effector Hrp-dependent CLM_2411 ENOG4105E98 transcriptional regulator DeoR family CLM_2412 ENOG4105KY5 gCN5-related N-acetyltransferase CLM_2415 ENOG4108IG5 Transcriptional regulator CLM_2419 ENOG41090FM Phosphatase CLM_2421 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit CLM_2425 ENOG4107RSS Hydrogenase accessory protein HypB CLM_2428 ENOG4105D1F ATP-binding protein CLM_2431 ENOG4105ER2 Ompa motb domain protein CLM_2432 ENOG4105E14 MotA TolQ exbB proton channel CLM_2434 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CLM_2437 ENOG4105EPD Oligopeptide transporter, Opt family CLM_2438 ENOG4105CIN aminoacyl-histidine dipeptidase CLM_2440 ENOG4105BZW Glycerate kinase CLM_2443 ENOG4105E1F short-chain dehydrogenase reductase CLM_2444 ENOG4108SDH ABC, transporter CLM_2445 ENOG4108IUW ABC transporter CLM_2446 ENOG4107YB6 acetyltransferase, (GNAT) family CLM_2447 ENOG4108U05 Transcriptional regulator CLM_2451 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A CLM_2453 ENOG4105E5D amino acid CLM_2454 ENOG4108UVJ appr-1-p processing domain protein CLM_2469 ENOG4105VKD bioY protein CLM_2472 ENOG4105DC7 peptidase M24 CLM_2473 ENOG4105DUX Transporter CLM_2514 ENOG4105MTC XkdN-like protein CLM_2529 ENOG4105IG6 Phage terminase, large subunit CLM_2533 ENOG4108J53 cell adhesion domain-containing protein CLM_2540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CLM_2558 ENOG4105KRN Transcriptional regulator, abrb family CLM_2573 ENOG4105XB7 anti-repressor protein CLM_2576 ENOG41068WC Domain of unknown function (DUF955) CLM_2578 ENOG4108C33 Resolvase CLM_2584 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CLM_2585 ENOG4105BZ1 (ABC) transporter CLM_2586 ENOG4105BZ1 (ABC) transporter CLM_2593 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CLM_2597 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CLM_2616 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CLM_2622 ENOG41062D9 Histidine kinase CLM_2623 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_2641 ENOG41066EA baseplate J family protein CLM_2650 ENOG4105FR7 XkdM protein, phage-like element PBSX CLM_2651 ENOG4105PQS phage protein CLM_2664 ENOG41061CV Terminase small subunit CLM_2670 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CLM_2680 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_2689 ENOG4105WG9 Conserved Protein CLM_2691 ENOG4105CHM Aminotransferase CLM_2692 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CLM_2694 ENOG4106YN8 Prenyltransferase CLM_2695 ENOG4105MCT stage V sporulation protein S CLM_2697 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CLM_2698 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CLM_2700 ENOG4105CNU cell division protein FtsK CLM_2701 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CLM_2704 ENOG4105C1V Peptidase, M16 CLM_2707 ENOG4105DTN riboflavin biosynthesis protein ribF CLM_2709 ENOG4105SFS phosphoesterase RecJ domain protein CLM_2712 ENOG4105VHM ribosomal protein CLM_2713 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CLM_2714 ENOG4105CHV Transcription elongation factor NusA CLM_2716 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CLM_2717 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CLM_2718 ENOG4105DZP Membrane-associated zinc metalloprotease CLM_2723 ENOG4105KNE Phosphatidate cytidylyltransferase CLM_2724 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CLM_2730 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CLM_2731 ENOG4105C79 DNA protecting protein DprA CLM_2732 ENOG4105C0P Mg chelatase subunit ChlI CLM_2735 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CLM_2740 ENOG4105VB6 UPF0109 protein CLM_2744 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CLM_2748 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CLM_2749 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CLM_2751 ENOG41067VY 50S ribosomal protein L32 CLM_2752 ENOG4105KNH Nucleic acid-binding protein CLM_2754 ENOG4108IJ2 phosphate acetyltransferase CLM_2759 ENOG41088D5 d-proline reductase CLM_2763 ENOG4105C8Q Methyl-accepting chemotaxis CLM_2768 ENOG4105E5D amino acid CLM_2770 ENOG4105CTU Proline racemase CLM_2776 ENOG41088D5 d-proline reductase CLM_2778 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CLM_2779 ENOG41088D5 d-proline reductase CLM_2780 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CLM_2787 ENOG41088D5 d-proline reductase CLM_2788 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) CLM_2789 ENOG4108JUB Transcriptional regulator CLM_2794 ENOG4106H78 methyltransferase CLM_2795 ENOG4105CB5 ATP-dependent DNA helicase recG CLM_2796 ENOG4105DP4 dak2 domain fusion protein ylov CLM_2797 ENOG4108ZAA Alkaline-shock protein CLM_2802 ENOG4105DJV ribulose-phosphate 3-epimerase CLM_2804 ENOG4105D9P serine threonine protein kinase CLM_2805 ENOG4108ZF3 Phosphatase CLM_2807 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CLM_2809 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CLM_2810 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CLM_2811 ENOG4105C25 Primosomal protein n' CLM_2812 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CLM_2814 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CLM_2816 ENOG4105DSJ YicC domain protein CLM_2817 ENOG4105HDK L-asparaginase CLM_2819 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CLM_2823 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CLM_2826 ENOG4108UTW Plays a role in the regulation of phosphate uptake CLM_2827 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CLM_2828 ENOG4105E2Z phosphate ABC transporter (Permease CLM_2829 ENOG4105C8U phosphate abc transporter CLM_2830 ENOG4105CVA phosphate CLM_2831 ENOG4105BZU Histidine kinase CLM_2832 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_2833 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CLM_2835 ENOG4108BIK prc-barrel domain-containing protein CLM_2836 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_2837 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_2838 ENOG4105FFI sigma-e processing peptidase spoiiga CLM_2839 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CLM_2840 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CLM_2843 ENOG4105CZX twitching motility protein CLM_2845 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_2850 ENOG4105T2N Domain of unknown function (DUF2382) CLM_2860 ENOG4105CJN penicillin-binding protein CLM_2862 ENOG4105CFP Peptidase U32 CLM_2863 ENOG4108VQJ O-methyltransferase CLM_2864 ENOG4105HHA aminodeoxychorismate lyase CLM_2865 ENOG4105CI3 gtp-binding protein typa CLM_2866 ENOG4105CN5 Metallo-Beta-Lactamase CLM_2867 ENOG4105I3K Ferric uptake regulator, Fur family CLM_2872 ENOG4105C02 permease CLM_2874 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) CLM_2877 ENOG4105D1H recombination factor protein RarA CLM_2878 ENOG4107RVV histidinol phosphate phosphatase, hisj family CLM_2883 ENOG4105BZG amino acid carrier protein CLM_2884 ENOG4105BZG amino acid carrier protein CLM_2887 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CLM_2889 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CLM_2892 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CLM_2903 ENOG4105DWK Membrane CLM_2905 ENOG4105VPX protein, conserved in bacteria CLM_2909 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CLM_2910 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CLM_2912 ENOG4105DB7 PHP domain protein CLM_2935 ENOG4105CAR Terminase, large subunit CLM_2966 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CLM_2967 ENOG4105DFM M18 family aminopeptidase CLM_2968 ENOG4105D7N magnesium and cobalt transport protein CorA CLM_2969 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CLM_2972 ENOG4108N5C SNARE associated Golgi protein-related protein CLM_2977 ENOG4105CKK Glycosyl transferase, family 2 CLM_2978 ENOG4105KHC sulfurtransferase CLM_2979 ENOG4105CBT Fructose-1,6-bisphosphatase CLM_2982 ENOG4105CNW domain protein CLM_3003 ENOG4105CGA flagellar basal-body rod protein FlgG CLM_3004 ENOG4105CGA flagellar basal-body rod protein FlgG CLM_3007 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_3010 ENOG4105FZW flagellar biosynthesis regulator FlhF CLM_3011 ENOG4105D7B Flagellar biosynthesis protein flha CLM_3012 ENOG4105D00 flagellar biosynthetic protein flhB CLM_3014 ENOG4105CN7 Flagellar biosynthetic protein FliP CLM_3016 ENOG4105X6C Flagellar basal body-associated protein FliL CLM_3017 ENOG4106VK6 Flagellar motor protein CLM_3018 ENOG4107R0U MotA TolQ exbB proton channel CLM_3019 ENOG41068WV flagellar FlbD family protein CLM_3020 ENOG4108JQA flagellar CLM_3022 ENOG410822I Flagellar hook capping protein CLM_3027 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CLM_3028 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CLM_3029 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CLM_3030 ENOG4108ZC9 flagellar basal-body rod protein flgc CLM_3031 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CLM_3032 ENOG4105I03 Flagellin CLM_3038 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CLM_3039 ENOG4108V3A UPF0421 protein CLM_3044 ENOG4105D2T synthase CLM_3045 ENOG4105F0R Cytidylyltransferase CLM_3049 ENOG4105D5D udp-galactopyranose mutase CLM_3050 ENOG4105D3Q Sugar transferase CLM_3051 ENOG4107YJ4 chain length determinant protein CLM_3052 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CLM_3053 ENOG4105HTX biosynthesis protein CLM_3054 ENOG4108KGH TRANSCRIPTIONal CLM_3059 ENOG4105FKZ Methyl-accepting chemotaxis CLM_3060 ENOG4105I03 Flagellin CLM_3064 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG CLM_3067 ENOG4105K64 Glycosyl transferase, family 2 CLM_3079 ENOG4108IJ1 Dehydrogenase CLM_3081 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CLM_3084 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CLM_3087 ENOG4107TY6 Acylneuraminate cytidylyltransferase CLM_3089 ENOG4105CPF Cell wall formation (By similarity) CLM_3091 ENOG4105C5E polysaccharide biosynthesis protein CLM_3092 ENOG4107TVC Glycosyl transferase, family 2 CLM_3095 ENOG4106WTF Glycosyl transferase, family 2 CLM_3096 ENOG4105I03 Flagellin CLM_3097 ENOG4105I03 Flagellin CLM_3099 ENOG4107RT6 flagellar hook-associated CLM_3100 ENOG4105MQ3 flagellar protein FliS CLM_3106 ENOG4105E1Q flagellar hook-associated protein CLM_3109 ENOG4105DD5 Flagellar motor switch protein CLM_3110 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CLM_3111 ENOG4108V3W Chemotaxis protein, CheW CLM_3112 ENOG4107YTP response regulator receiver protein CLM_3114 ENOG4105CBS Chea signal transduction histidine kinase CLM_3115 ENOG4105BZU Histidine kinase CLM_3116 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CLM_3118 ENOG4108V3W Chemotaxis protein, CheW CLM_3120 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane CLM_3129 ENOG4105BZU Histidine kinase CLM_3130 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CLM_3132 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CLM_3136 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CLM_3137 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CLM_3138 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CLM_3140 ENOG4105CKD glutathione-regulated potassium-efflux system protein CLM_3145 ENOG4105CMR udp-glucose 4-epimerase CLM_3146 ENOG4108Z29 Flavodoxin CLM_3148 ENOG41075H3 AraC family transcriptional regulator CLM_3149 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CLM_3151 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CLM_3152 ENOG4105K8R UPF0145 protein CLM_3155 ENOG4105DVE abc transporter atp-binding protein CLM_3156 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CLM_3163 ENOG4105E1K spore germination protein CLM_3166 ENOG4105C1J atp-dependent rna helicase CLM_3169 ENOG4105C8Q Methyl-accepting chemotaxis CLM_3172 ENOG4108AC1 4fe-4s ferredoxin, iron-sulfur binding CLM_3174 ENOG41069ER domain protein CLM_3175 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CLM_3177 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CLM_3178 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CLM_3181 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CLM_3182 ENOG4107SJI Dehydrogenase CLM_3183 ENOG4105BZ8 glutamate synthase CLM_3184 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CLM_3187 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CLM_3189 ENOG41081HM 2'-5' rna ligase CLM_3191 ENOG4105C8Q Methyl-accepting chemotaxis CLM_3194 ENOG4105I3K Ferric uptake regulator, Fur family CLM_3198 ENOG4105CE4 GlcNAc 6-P deacetylase CLM_3199 ENOG4105FDP GntR family transcriptional regulator CLM_3200 ENOG4105CID antiterminator CLM_3201 ENOG4105C5Y PTS System CLM_3203 ENOG4107R73 Mate efflux family protein CLM_3204 ENOG4105DIW FeS assembly protein SUFB CLM_3205 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CLM_3207 ENOG4105I3K Ferric uptake regulator, Fur family CLM_3208 ENOG4105C3S Mate efflux family protein CLM_3209 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center CLM_3210 ENOG4105C1G acyl-Coa dehydrogenase CLM_3211 ENOG4105DQ6 Transposase CLM_3215 ENOG4105ETZ PTS System CLM_3216 ENOG4105F3R pts system mannose fructose sorbose family iid CLM_3218 ENOG4107QP7 CoA-transferase subunit A CLM_3220 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase CLM_3221 ENOG4108XHQ (2Fe-2S)-binding domain protein CLM_3223 ENOG4105C7W Xanthine dehydrogenase CLM_3227 ENOG4107RWR Sodium hydrogen exchanger CLM_3237 ENOG4105C5H ABC transporter CLM_3239 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) CLM_3240 ENOG4105KBX Transcriptional regulator, TetR family CLM_3247 ENOG41068WN CLM_3254 ENOG4105BZ1 (ABC) transporter CLM_3255 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CLM_3257 ENOG4105E0M Sulfatase CLM_3258 ENOG4105EJ9 Membrane CLM_3260 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CLM_3261 ENOG4108R6K riboflavin synthase, subunit alpha CLM_3262 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CLM_3264 ENOG4105CIN aminoacyl-histidine dipeptidase CLM_3265 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CLM_3266 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CLM_3269 ENOG4105C12 Phosphoribosylglycinamide synthetase CLM_3271 ENOG4108V3E phosphoribosylglycinamide formyltransferase CLM_3275 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CLM_3278 ENOG4107S4Y M20 DapE family protein YgeY CLM_3279 ENOG4107UUR Chlorohydrolase aminohydrolase CLM_3280 ENOG4105BZ8 glutamate synthase CLM_3281 ENOG4105IW6 Carbamoyltransferase CLM_3283 ENOG4105C2W permease CLM_3284 ENOG4107RCH Diaminopropionate ammonia-lyase CLM_3285 ENOG4108JUB Transcriptional regulator CLM_3286 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC CLM_3287 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CLM_3288 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family CLM_3291 ENOG4105EHG Permease protein CLM_3292 ENOG4105E0A ABC, transporter CLM_3297 ENOG4105C7N Xanthine uracil vitamin C permease CLM_3299 ENOG4105BZG amino acid carrier protein CLM_3300 ENOG4105EEM helicase CLM_3304 ENOG4108ZGC gaf domain protein CLM_3305 ENOG4105C37 (CBS) domain CLM_3315 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CLM_3316 ENOG4105NBU tryptophan transport protein CLM_3318 ENOG4107V6Q Cyclic nucleotide-binding domain CLM_3323 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CLM_3329 ENOG4105EGD dinuclear metal center protein, YbgI family CLM_3332 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_3333 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CLM_3334 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CLM_3336 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CLM_3338 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CLM_3344 ENOG4105CTJ Metal Dependent Phosphohydrolase CLM_3347 ENOG4105KTH gatB Yqey CLM_3349 ENOG4107YU2 histidine triad (hIT) protein CLM_3350 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CLM_3351 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CLM_3353 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CLM_3355 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CLM_3356 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CLM_3357 ENOG4105CSA Coproporphyrinogen iii oxidase CLM_3361 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) CLM_3370 ENOG4105EM7 Selenocysteine-specific translation elongation factor CLM_3372 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) CLM_3374 ENOG4105DZ1 carboxypeptidase CLM_3375 ENOG4108YBP pseudouridine synthase CLM_3376 ENOG4105KME endoribonuclease L-psp CLM_3377 ENOG4108KGH TRANSCRIPTIONal CLM_3378 ENOG4108WF2 Metal Dependent Phosphohydrolase CLM_3380 ENOG410812S Rna-binding protein CLM_3386 ENOG4105C03 ribonuclease CLM_3390 ENOG4105DR5 peptidase CLM_3391 ENOG4105CNI cell division protein FtsW CLM_3393 ENOG4107QMS site-determining protein CLM_3394 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CLM_3395 ENOG4107RF6 penicillin-binding protein CLM_3398 ENOG4105DFF Rod shape-determining protein mreb CLM_3410 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CLM_3411 ENOG4105C2M dna polymerase I CLM_3412 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CLM_3451 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CLM_3461 ENOG4105D4P Coproporphyrinogen iii oxidase CLM_3462 ENOG4105C5X domain protein CLM_3464 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CLM_3467 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CLM_3468 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CLM_3472 ENOG4105VIE preprotein translocase, subunit YajC CLM_3479 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CLM_3484 ENOG4105VCQ rubredoxin CLM_3485 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CLM_3486 ENOG4108UGV hypoxanthine phosphoribosyltransferase CLM_3490 ENOG4105CZ3 stage V sporulation protein ad CLM_3491 ENOG41090VF Stage v sporulation protein ac CLM_3492 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CLM_3494 ENOG41082AN stage II sporulation protein CLM_3495 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CLM_3499 ENOG4105D3Q Sugar transferase CLM_3501 ENOG4105CJR Integral membrane protein (MviN CLM_3503 ENOG4105CPK Glycosyl transferase (Group 1 CLM_3506 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CLM_3507 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CLM_3514 ENOG4107QQG Dehydrogenase CLM_3519 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CLM_3522 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CLM_3523 ENOG4105CXN decarboxylase CLM_3525 ENOG4107RE7 phosphate butyryltransferase CLM_3527 ENOG4105EWC Purine nucleoside phosphorylase CLM_3529 ENOG4105CFP Peptidase U32 CLM_3535 ENOG4107TVC Glycosyl transferase, family 2 CLM_3537 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CLM_3539 ENOG4108RWN rrna methyltransferase CLM_3540 ENOG4107ZYR domain protein CLM_3541 ENOG4105CZN Potassium uptake protein CLM_3544 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CLM_3550 ENOG4105DA5 (ABC) transporter CLM_3557 ENOG4108D32 Methyltransferase CLM_3559 ENOG4108JQ7 (ABC) transporter CLM_3561 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CLM_3562 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CLM_3563 ENOG4107QSI ABC, transporter CLM_3564 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CLM_3565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CLM_3566 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CLM_3567 ENOG4105CHM Aminotransferase CLM_3576 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CLM_3577 ENOG41080E2 ribosomal-protein-alanine acetyltransferase CLM_3578 ENOG4105C19 ABC transporter CLM_3580 ENOG4105D2X ABC transporter substrate-binding protein CLM_3583 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CLM_3587 ENOG4108J6I peptidase, M16 CLM_3593 ENOG4105NBK UPF0345 protein CLM_3594 ENOG4105II7 pyrroline-5-carboxylate reductase CLM_3595 ENOG4105C6N Formate acetyltransferase CLM_3596 ENOG4105F1A Pyruvate formate-lyase CLM_3597 ENOG4105WBV Transcriptional regulator CLM_3601 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) CLM_3607 ENOG4105CIZ coA-substrate-specific enzyme activase CLM_3609 ENOG4105C10 Electron transfer flavoprotein CLM_3610 ENOG4105BZJ Electron transfer flavoprotein CLM_3611 ENOG4105C1G acyl-Coa dehydrogenase CLM_3612 ENOG4105CHU acetyl-coa acetyltransferase CLM_3613 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CLM_3614 ENOG4105E39 Enoyl-CoA hydratase CLM_3617 ENOG4105C7N Xanthine uracil vitamin C permease CLM_3618 ENOG4105EQI Metal Dependent Phosphohydrolase CLM_3623 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CLM_3624 ENOG4105C8Q Methyl-accepting chemotaxis CLM_3625 ENOG4105KY8 Rubrerythrin CLM_3629 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CLM_3631 ENOG4105G5W regulator Fur family CLM_3634 ENOG4105D29 Helix-turn-helix type 11 domain protein CLM_3639 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CLM_3640 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CLM_3641 ENOG4108IUQ atp-dependent protease CLM_3645 ENOG4107TRN Xylose isomerase domain protein TIM barrel CLM_3648 ENOG4107W93 Dihydroorotate dehydrogenase CLM_3649 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CLM_3655 ENOG4105CIZ coA-substrate-specific enzyme activase CLM_3657 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase CLM_3658 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase CLM_3662 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CLM_3695 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CLM_3698 ENOG4105DEF Extracellular solute-binding protein, family 5 CLM_3705 ENOG4105C4R Atp-dependent dna helicase CLM_3706 ENOG4105KGF protein, YerC YecD CLM_3708 ENOG4105E4C Lytic transglycosylase catalytic CLM_3711 ENOG4107XJU UPF0178 protein CLM_3716 ENOG4105C5I Dehydrogenase CLM_3719 ENOG4105C10 Electron transfer flavoprotein CLM_3720 ENOG4105BZJ Electron transfer flavoprotein CLM_3721 ENOG4105C1G acyl-Coa dehydrogenase CLM_3726 ENOG4105CEY Amp-dependent synthetase and ligase CLM_3729 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CLM_3731 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) CLM_3739 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein CLM_3741 ENOG4105C5H ABC transporter CLM_3742 ENOG4105DY9 regulatoR CLM_3743 ENOG4108HRK Histidine kinase CLM_3746 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CLM_3754 ENOG4105DSE periplasmic solute binding protein CLM_3755 ENOG4105DHT Metal Dependent Phosphohydrolase CLM_3756 ENOG4105K8N protein family UPF0079, ATPase CLM_3757 ENOG41072GX Peptidase M22 Glycoprotease CLM_3758 ENOG410801F ribosomal-protein-alanine acetyltransferase CLM_3765 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CLM_3766 ENOG410667J hydrolase CLM_3767 ENOG4105C31 Tryptophanyl-tRNA synthetase CLM_3769 ENOG4105MAX Superoxide reductase CLM_3773 ENOG4105CJ1 ABC, transporter CLM_3778 ENOG4105BZ1 (ABC) transporter CLM_3779 ENOG4105E2V Glycosyltransferase 36 CLM_3783 ENOG4105DFM M18 family aminopeptidase CLM_3786 ENOG4105EEM helicase CLM_3787 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CLM_3788 ENOG4107QSE Dipeptidase CLM_3790 ENOG4105VC4 domain protein CLM_3792 ENOG4105DA5 (ABC) transporter CLM_3794 ENOG4105JVQ RNA Polymerase CLM_3795 ENOG4105CHH sulfate transporter CLM_3799 ENOG4105CJ1 ABC, transporter CLM_3803 ENOG4105RD7 BadF BadG BcrA BcrD CLM_3804 ENOG4105VCP PTS System CLM_3806 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CLM_3807 ENOG4105CK1 PTS System CLM_3808 ENOG4105F8D glycoside hydrolase family 4 CLM_3810 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CLM_3814 ENOG4105X5K response regulator receiver protein CLM_3819 ENOG4105VUF Transcriptional regulator CLM_3820 ENOG4107ZT6 cytidine deaminase CLM_3822 ENOG4105UEI Transcriptional Regulator AraC Family CLM_3823 ENOG4105NAE bifunctional deaminase-reductase domain protein CLM_3827 ENOG41062ES Transcriptional regulator CLM_3828 ENOG4108Z1Z gCN5-related N-acetyltransferase CLM_3829 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CLM_3834 ENOG4105CA9 Pyruvate kinase CLM_3836 ENOG4105C0B DNA polymerase III (alpha subunit) CLM_3838 ENOG4105CHW UPF0052 protein CLM_3843 ENOG4107K5X Membrane-bound metal-dependent hydrolase CLM_3845 ENOG4105CJN penicillin-binding protein CLM_3847 ENOG4105TV9 FHA Domain-Containing protein CLM_3848 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CLM_3850 ENOG4105DZP Membrane-associated zinc metalloprotease CLM_3852 ENOG4105CRP Part of the ABC transporter FtsEX involved in CLM_3853 ENOG4105CAK Cell division ATP-binding protein ftsE CLM_3854 ENOG4108JYZ YitT family CLM_3857 ENOG4108HHA Transketolase CLM_3860 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CLM_3862 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CLM_3863 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CLM_3867 ENOG4107U9T Pfam:Ribonuclease_BN CLM_3872 ENOG4108Z5V transcriptional regulator, merr family CLM_3874 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CLM_3875 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CLM_3877 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CLM_3878 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 CLM_3879 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase CLM_3880 ENOG4105VI0 Pts system, glucitol sorbitol-specific CLM_3881 ENOG4105DZY Pts system, glucitol sorbitol-specific CLM_3882 ENOG410787A Pts system, glucitol sorbitol-specific CLM_3884 ENOG4107WTH Galactitol-1-phosphate dehydrogenase CLM_3885 ENOG4105DKT Transcriptional regulator CLM_3889 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CLM_3892 ENOG4105CKM Branched-chain carboxylic acid kinase CLM_3893 ENOG4107RE7 phosphate butyryltransferase CLM_3894 ENOG4105CKM Branched-chain carboxylic acid kinase CLM_3895 ENOG4105DZ0 fad dependent oxidoreductase CLM_3897 ENOG4105C8B TIGR00159 family CLM_3899 ENOG4105F0V Cell wall hydrolase CLM_3900 ENOG4105C3M thioredoxin reductase CLM_3901 ENOG4105K63 Thioredoxin CLM_3902 ENOG4105DYB Isoaspartyl dipeptidase CLM_3905 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CLM_3906 ENOG4108JUB Transcriptional regulator CLM_3909 ENOG4107GFK fumarate CLM_3910 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase CLM_3914 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CLM_3915 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CLM_3916 ENOG4108JJB ABC transporter CLM_3917 ENOG4108JJB ABC transporter CLM_3928 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CLM_3943 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CLM_3954 ENOG4105XPM ribosomal protein CLM_3958 ENOG4108VZM 50s ribosomal protein L10 CLM_3961 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CLM_3967 ENOG4105QIV RNA polymerase CLM_3969 ENOG4105C2N RNA methyltransferase TrmH family group 3 CLM_3970 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) CLM_3971 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CLM_3973 ENOG4105C7B Threonine dehydratase CLM_3974 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CLM_3976 ENOG4105CTP PilT protein domain protein CLM_3979 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CLM_3982 ENOG4108Z0C Uvrb UvrC protein CLM_3985 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CLM_4003 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CLM_4007 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CLM_4010 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CLM_4011 ENOG4108UGV hypoxanthine phosphoribosyltransferase CLM_4012 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CLM_4021 ENOG41060GV RNA binding s1 domain protein CLM_4025 ENOG41082I2 s4 domain protein CLM_4027 ENOG4108IY2 MazG family CLM_4028 ENOG4105CKP Polysaccharide Biosynthesis Protein CLM_4029 ENOG4108M14 stage v sporulation protein t CLM_4031 ENOG4108JA2 transcriptioN-repair coupling factor CLM_4033 ENOG4105C0H protease CLM_4034 ENOG4105BZU Histidine kinase CLM_4035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CLM_4036 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CLM_4039 ENOG4105DFT pur operon repressor CLM_4044 ENOG4107VXZ Hydrolase CLM_4047 ENOG4105N5T Radical SAM Protein CLM_4049 ENOG4108K88 Membrane CLM_4051 ENOG4105C8Q Methyl-accepting chemotaxis CLM_4054 ENOG4107ZE5 PPIases accelerate the folding of proteins CLM_4056 ENOG4105CFQ glutamine synthetase CLM_4059 ENOG4105Q2H domain protein CLM_4061 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CLM_4065 ENOG4105EQ0 Major Facilitator superfamily CLM_4067 ENOG4108JGH Tetr family transcriptional regulator CLM_4068 ENOG4105HFT AraC family transcriptional regulator CLM_4069 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CLM_4070 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase CLM_4071 ENOG4105G0K glycine radical enzyme YjjI family CLM_4072 ENOG41076CZ activating enzyme CLM_4074 ENOG4107QW8 radical SAM domain protein CLM_4076 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CLM_4078 ENOG4105CG5 Glycosyl transferase (Group 1 CLM_4079 ENOG4105DB7 PHP domain protein CLM_4082 ENOG4105DUM transcriptional regulator, lysR family CLM_4083 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin CLM_4086 ENOG4108FRU Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CLM_4088 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CLM_4091 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CLM_4092 ENOG4105CHR reductase CLM_4093 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CLM_4094 ENOG4105EA8 2-Nitropropane dioxygenase CLM_4099 ENOG4105DR5 peptidase CLM_4118 ENOG4105CBX hi0933 family CLM_4125 ENOG4105CDU Replicative dna helicase CLM_4126 ENOG4108IUQ atp-dependent protease CLM_4128 ENOG4105BZR domain protein CLM_4132 ENOG4108UUM single-stranded DNA-binding protein CLM_4134 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase CLM_4136 ENOG4105D8X mechanosensitive ion channel CLM_4138 ENOG4105C9B Cysteine desulfurase CLM_4139 ENOG4108REF Sporulation integral membrane protein ytvi CLM_4140 ENOG4108ZDA Sporulation protein YyaC CLM_4143 ENOG4105FA0 parb-like partition protein CLM_4144 ENOG4107QJE Chromosome Partitioning Protein CLM_4145 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) CLM_4150 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins