locus-tag	class	description
CLM_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLM_0002	COG0592	DNA-directed DNA polymerase activity
CLM_0006	COG0187	DNA topoisomerase II activity
CLM_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLM_0016	COG1827	regulation of RNA biosynthetic process
CLM_0017	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLM_0018	COG1615	UPF0182 protein
CLM_0022	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLM_0028	COG0688	phosphatidylethanolamine metabolic process
CLM_0033	COG0626	cystathionine gamma-synthase activity
CLM_0037	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLM_0043	COG2816	NAD+ diphosphatase activity
CLM_0047	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLM_0049	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLM_0074	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CLM_0083	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLM_0091	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLM_0096	COG1982	Orn Lys Arg decarboxylase major
CLM_0098	COG3870	Protein conserved in bacteria
CLM_0099	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLM_0100	COG1774	PSP1 C-terminal conserved region
CLM_0103	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLM_0104	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLM_0105	COG0791	NLP P60 protein
CLM_0110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLM_0112	COG0726	polysaccharide deacetylase
CLM_0114	COG2715	membrane protein required for spore maturation
CLM_0115	COG0700	Nucleoside recognition
CLM_0116	COG0534	Mate efflux family protein
CLM_0117	COG1573	uracil-dna glycosylase
CLM_0119	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM_0119	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM_0120	COG4399	Belongs to the UPF0754 family
CLM_0121	COG0084	hydrolase, TatD family'
CLM_0122	COG3584	3D domain protein
CLM_0122	COG3583	domain protein
CLM_0124	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLM_0129	COG1136	(ABC) transporter
CLM_0130	COG0577	efflux transmembrane transporter activity
CLM_0132	COG1141	Ferredoxin
CLM_0135	COG3706	GGDEF domain
CLM_0136	COG1285	pathogenesis
CLM_0137	COG1328	CTP reductase activity
CLM_0141	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLM_0142	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLM_0144	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CLM_0145	COG0662	Cupin 2, conserved barrel domain protein
CLM_0145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CLM_0146	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLM_0147	COG1606	tRNA processing
CLM_0148	COG1691	(AIR) carboxylase
CLM_0150	COG1653	transport
CLM_0152	COG3642	lipopolysaccharide core region biosynthetic process
CLM_0159	COG4466	Protein conserved in bacteria
CLM_0162	COG4242	Belongs to the peptidase S51 family
CLM_0163	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLM_0163	COG0189	ligase activity
CLM_0166	COG0697	spore germination
CLM_0167	COG0531	amino acid
CLM_0170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLM_0171	COG2959	enzyme of heme biosynthesis
CLM_0175	COG0504	CTP synthase activity
CLM_0177	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLM_0180	COG3872	metal-dependent enzyme
CLM_0182	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLM_0185	COG0009	L-threonylcarbamoyladenylate synthase
CLM_0186	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLM_0187	COG0698	ribose 5-phosphate isomerase
CLM_0191	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLM_0192	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLM_0194	COG0356	it plays a direct role in the translocation of protons across the membrane
CLM_0197	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLM_0199	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLM_0200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLM_0204	COG2385	sporulation resulting in formation of a cellular spore
CLM_0206	COG1609	Transcriptional regulator
CLM_0209	COG0037	tRNA processing
CLM_0216	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLM_0217	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLM_0221	COG0653	protein targeting
CLM_0224	COG2183	response to ionizing radiation
CLM_0226	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CLM_0231	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLM_0233	COG2357	RelA SpoT domain protein
CLM_0235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CLM_0238	COG0484	heat shock protein binding
CLM_0242	COG0191	fructose-bisphosphate aldolase activity
CLM_0244	COG2323	membrane
CLM_0245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLM_0247	COG1183	phosphatidylcholine synthase activity
CLM_0248	COG0517	IMP dehydrogenase activity
CLM_0249	COG1597	lipid kinase activity
CLM_0251	COG1032	radical SAM domain protein
CLM_0254	COG3773	Cell wall hydrolase
CLM_0254	COG3409	Peptidoglycan-binding domain 1 protein
CLM_0255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLM_0256	COG1045	serine acetyltransferase
CLM_0257	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLM_0259	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLM_0260	COG0281	malic enzyme
CLM_0261	COG1058	Belongs to the CinA family
CLM_0261	COG1546	Belongs to the CinA family
CLM_0262	COG1073	alpha beta
CLM_0263	COG1363	Peptidase, m42
CLM_0264	COG2720	vancomycin resistance protein
CLM_0265	COG2720	vancomycin resistance protein
CLM_0266	COG1533	DNA photolyase activity
CLM_0267	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLM_0268	COG1307	EDD domain protein, DegV family
CLM_0273	COG0726	polysaccharide deacetylase
CLM_0274	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLM_0276	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLM_0277	COG0126	phosphoglycerate kinase activity
CLM_0280	COG0148	phosphopyruvate hydratase activity
CLM_0282	COG0557	exoribonuclease II activity
CLM_0283	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLM_0287	COG0277	FAD linked oxidase domain protein
CLM_0288	COG2226	methyltransferase
CLM_0291	COG0076	glutamate decarboxylase activity
CLM_0295	COG0745	RESPONSE REGULATOR receiver
CLM_0298	COG2205	protein histidine kinase activity
CLM_0299	COG0662	Cupin 2, conserved barrel domain protein
CLM_0302	COG0833	amino acid
CLM_0307	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLM_0308	COG2176	DNA-directed DNA polymerase activity
CLM_0315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM_0317	COG2323	membrane
CLM_0321	COG0785	Cytochrome C biogenesis protein
CLM_0322	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM_0324	COG2205	protein histidine kinase activity
CLM_0325	COG0277	FAD linked oxidase domain protein
CLM_0326	COG1486	melibiose metabolic process
CLM_0327	COG1263	PTS System
CLM_0327	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_0330	COG2190	(PTS) system
CLM_0331	COG0745	RESPONSE REGULATOR receiver
CLM_0332	COG5002	protein histidine kinase activity
CLM_0333	COG1136	(ABC) transporter
CLM_0334	COG0577	efflux transmembrane transporter activity
CLM_0335	COG1263	PTS System
CLM_0335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_0336	COG1486	melibiose metabolic process
CLM_0337	COG2190	(PTS) system
CLM_0337	COG1263	PTS System
CLM_0337	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_0340	COG1278	Cold shock
CLM_0342	COG1959	2 iron, 2 sulfur cluster binding
CLM_0343	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CLM_0344	COG2910	NAD(P)H-binding
CLM_0345	COG1737	Transcriptional regulator
CLM_0346	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_0346	COG1263	PTS System
CLM_0348	COG1263	PTS System
CLM_0348	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_0348	COG2190	(PTS) system
CLM_0349	COG0129	dihydroxy-acid dehydratase activity
CLM_0351	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM_0353	COG0745	RESPONSE REGULATOR receiver
CLM_0354	COG2205	protein histidine kinase activity
CLM_0354	COG2770	Histidine kinase
CLM_0355	COG0463	Glycosyl transferase, family 2
CLM_0356	COG2246	polysaccharide biosynthetic process
CLM_0357	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLM_0362	COG1120	ATPase activity
CLM_0367	COG3279	Response regulator of the LytR AlgR family
CLM_0370	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLM_0378	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLM_0379	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM_0380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM_0381	COG1120	ATPase activity
CLM_0382	COG1132	(ABC) transporter
CLM_0386	COG0745	RESPONSE REGULATOR receiver
CLM_0387	COG2205	protein histidine kinase activity
CLM_0389	COG1136	(ABC) transporter
CLM_0390	COG0577	efflux transmembrane transporter activity
CLM_0393	COG1346	cytolysis
CLM_0396	COG4868	Belongs to the UPF0371 family
CLM_0401	COG2203	Gaf domain
CLM_0401	COG3706	GGDEF domain
CLM_0401	COG4251	negative regulation of phosphorylation
CLM_0401	COG5001	Diguanylate cyclase
CLM_0404	COG5002	protein histidine kinase activity
CLM_0408	COG5002	protein histidine kinase activity
CLM_0409	COG0037	tRNA processing
CLM_0410	COG1396	sequence-specific DNA binding
CLM_0410	COG3800	Transcriptional regulator
CLM_0411	COG0531	amino acid
CLM_0412	COG0006	proline dipeptidase activity
CLM_0418	COG0671	phosphoesterase, PA-phosphatase related
CLM_0420	COG0745	RESPONSE REGULATOR receiver
CLM_0421	COG3850	Histidine kinase
CLM_0421	COG5002	protein histidine kinase activity
CLM_0423	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CLM_0424	COG0398	Pfam SNARE associated Golgi protein
CLM_0430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLM_0434	COG5002	protein histidine kinase activity
CLM_0435	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLM_0436	COG4656	Part of a membrane complex involved in electron transport
CLM_0437	COG4658	electron transport chain
CLM_0438	COG4659	FMN binding
CLM_0439	COG4660	Part of a membrane complex involved in electron transport
CLM_0440	COG4657	Part of a membrane complex involved in electron transport
CLM_0441	COG2878	Part of a membrane complex involved in electron transport
CLM_0441	COG1245	4Fe-4S binding domain
CLM_0445	COG1477	protein flavinylation
CLM_0451	COG2385	sporulation resulting in formation of a cellular spore
CLM_0451	COG2247	cell wall binding repeat
CLM_0454	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLM_0455	COG0573	inorganic phosphate transmembrane transporter activity
CLM_0459	COG0531	amino acid
CLM_0463	COG0629	single-stranded DNA binding
CLM_0468	COG0457	Tetratricopeptide repeat
CLM_0468	COG0705	Rhomboid family
CLM_0470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLM_0481	COG3442	glutamine amidotransferase
CLM_0482	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLM_0483	COG1482	cell wall glycoprotein biosynthetic process
CLM_0485	COG1968	undecaprenyl-diphosphatase activity
CLM_0494	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLM_0496	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLM_0497	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLM_0498	COG0473	3-isopropylmalate dehydrogenase activity
CLM_0499	COG1126	abc transporter atp-binding protein
CLM_0501	COG1757	Na H antiporter
CLM_0502	COG2155	Conserved Protein
CLM_0504	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLM_0505	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLM_0513	COG0375	protein maturation
CLM_0518	COG1074	ATP-dependent DNA helicase activity
CLM_0519	COG3290	protein histidine kinase activity
CLM_0519	COG0840	transmembrane signaling receptor activity
CLM_0520	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLM_0521	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLM_0524	COG0456	acetyltransferase
CLM_0528	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLM_0529	COG2226	methyltransferase
CLM_0530	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CLM_0531	COG0352	thiamine-phosphate diphosphorylase activity
CLM_0532	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLM_0533	COG0352	thiamine-phosphate diphosphorylase activity
CLM_0533	COG0351	phosphomethylpyrimidine kinase
CLM_0537	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLM_0540	COG0410	ABC transporter
CLM_0544	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_0547	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CLM_0551	COG2226	methyltransferase
CLM_0552	COG3655	Transcriptional regulator
CLM_0555	COG0420	3'-5' exonuclease activity
CLM_0556	COG0419	ATPase involved in DNA repair
CLM_0558	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLM_0560	COG0640	Transcriptional regulator
CLM_0561	COG2217	Heavy metal translocating P-type atpase
CLM_0569	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CLM_0570	COG5434	Belongs to the glycosyl hydrolase 28 family
CLM_0570	COG4632	Exopolysaccharide biosynthesis protein
CLM_0578	COG1131	(ABC) transporter
CLM_0582	COG1994	Peptidase M50
CLM_0584	COG2197	response regulator
CLM_0585	COG1131	(ABC) transporter
CLM_0587	COG0842	Transport permease protein
CLM_0593	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLM_0594	COG1028	Short-chain dehydrogenase reductase Sdr
CLM_0597	COG2267	carboxylic ester hydrolase activity
CLM_0598	COG0745	RESPONSE REGULATOR receiver
CLM_0600	COG0840	transmembrane signaling receptor activity
CLM_0601	COG2204	response regulator
CLM_0602	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLM_0603	COG1199	ATP-dependent helicase activity
CLM_0607	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CLM_0609	COG2703	oxygen carrier activity
CLM_0619	COG1132	(ABC) transporter
CLM_0622	COG1136	(ABC) transporter
CLM_0625	COG0531	amino acid
CLM_0627	COG1522	sequence-specific DNA binding
CLM_0629	COG0531	amino acid
CLM_0630	COG0531	amino acid
CLM_0631	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CLM_0632	COG0658	competence protein
CLM_0632	COG2333	competence protein COMEC
CLM_0635	COG2059	Chromate
CLM_0636	COG2059	Chromate
CLM_0637	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLM_0639	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLM_0639	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLM_0643	COG0006	proline dipeptidase activity
CLM_0650	COG1073	alpha beta
CLM_0652	COG1966	Carbon starvation protein
CLM_0655	COG0488	(ABC) transporter
CLM_0660	COG0653	protein targeting
CLM_0661	COG1725	Transcriptional regulator
CLM_0662	COG1131	(ABC) transporter
CLM_0666	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLM_0667	COG1177	transmembrane transport
CLM_0670	COG1301	dicarboxylic acid transport
CLM_0674	COG3409	Peptidoglycan-binding domain 1 protein
CLM_0680	COG1357	PFAM Pentapeptide repeats (8 copies)
CLM_0686	COG3279	Response regulator of the LytR AlgR family
CLM_0694	COG1132	(ABC) transporter
CLM_0698	COG1136	(ABC) transporter
CLM_0700	COG1307	EDD domain protein, DegV family
CLM_0703	COG1368	sulfuric ester hydrolase activity
CLM_0705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLM_0709	COG2207	Transcriptional regulator
CLM_0709	COG3708	Transcriptional regulator
CLM_0714	COG0745	RESPONSE REGULATOR receiver
CLM_0715	COG2205	protein histidine kinase activity
CLM_0717	COG1876	peptidase activity
CLM_0719	COG5002	protein histidine kinase activity
CLM_0721	COG0784	Response regulator, receiver
CLM_0722	COG5002	protein histidine kinase activity
CLM_0723	COG0772	Belongs to the SEDS family
CLM_0724	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLM_0726	COG1132	(ABC) transporter
CLM_0730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLM_0731	COG2207	Transcriptional regulator
CLM_0732	COG1396	sequence-specific DNA binding
CLM_0734	COG3279	Response regulator of the LytR AlgR family
CLM_0738	COG0346	lactoylglutathione lyase activity
CLM_0739	COG1193	negative regulation of DNA recombination
CLM_0743	COG2832	Protein of unknown function (DUF454)
CLM_0747	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_0749	COG0513	Belongs to the DEAD box helicase family
CLM_0754	COG0583	DNA-binding transcription factor activity
CLM_0758	COG2949	membrane
CLM_0761	COG0494	nUDIX hydrolase
CLM_0764	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CLM_0767	COG3711	transcriptional antiterminator
CLM_0768	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_0768	COG1263	PTS System
CLM_0768	COG2190	(PTS) system
CLM_0769	COG0613	PHP domain protein
CLM_0771	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM_0773	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CLM_0776	COG0786	glutamate:sodium symporter activity
CLM_0781	COG4120	Belongs to the binding-protein-dependent transport system permease family
CLM_0782	COG1122	ATPase activity
CLM_0786	COG2112	serine threonine protein kinase
CLM_0789	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLM_0790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM_0795	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CLM_0797	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CLM_0798	COG2367	Beta-lactamase
CLM_0800	COG4219	Peptidase M56
CLM_0800	COG2602	Beta-lactamase
CLM_0804	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM_0805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM_0806	COG1120	ATPase activity
CLM_0808	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CLM_0810	COG0840	transmembrane signaling receptor activity
CLM_0815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CLM_0816	COG0509	glycine decarboxylation via glycine cleavage system
CLM_0817	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLM_0818	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CLM_0820	COG0095	Lipoate-protein ligase
CLM_0824	COG3328	transposase activity
CLM_0825	COG0745	RESPONSE REGULATOR receiver
CLM_0826	COG5002	protein histidine kinase activity
CLM_0827	COG1136	(ABC) transporter
CLM_0827	COG0577	efflux transmembrane transporter activity
CLM_0829	COG1846	Transcriptional regulator
CLM_0834	COG0789	Transcriptional regulator
CLM_0837	COG0697	spore germination
CLM_0838	COG1476	TRANSCRIPTIONal
CLM_0842	COG2207	Transcriptional regulator
CLM_0846	COG1476	TRANSCRIPTIONal
CLM_0849	COG0789	Transcriptional regulator
CLM_0852	COG3973	AAA domain
CLM_0854	COG2207	Transcriptional regulator
CLM_0854	COG3708	Transcriptional regulator
CLM_0856	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM_0857	COG0840	transmembrane signaling receptor activity
CLM_0860	COG0488	(ABC) transporter
CLM_0866	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLM_0868	COG0626	cystathionine gamma-synthase activity
CLM_0869	COG2226	methyltransferase
CLM_0872	COG2226	methyltransferase
CLM_0874	COG3708	Transcriptional regulator
CLM_0874	COG2207	Transcriptional regulator
CLM_0909	COG0798	PFAM Bile acid sodium symporter
CLM_0912	COG2226	methyltransferase
CLM_0915	COG1131	(ABC) transporter
CLM_0921	COG0352	thiamine-phosphate diphosphorylase activity
CLM_0921	COG0351	phosphomethylpyrimidine kinase
CLM_0924	COG1131	(ABC) transporter
CLM_0926	COG0745	RESPONSE REGULATOR receiver
CLM_0929	COG2207	Transcriptional regulator
CLM_0929	COG3708	Transcriptional regulator
CLM_0933	COG0577	efflux transmembrane transporter activity
CLM_0933	COG1136	(ABC) transporter
CLM_0936	COG0745	RESPONSE REGULATOR receiver
CLM_0937	COG5002	protein histidine kinase activity
CLM_0937	COG3850	Histidine kinase
CLM_0942	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLM_0949	COG4974	Belongs to the 'phage' integrase family
CLM_0950	COG0346	lactoylglutathione lyase activity
CLM_0954	COG1114	Component of the transport system for branched-chain amino acids
CLM_0955	COG1114	Component of the transport system for branched-chain amino acids
CLM_0958	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLM_0959	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLM_0961	COG0406	alpha-ribazole phosphatase activity
CLM_0962	COG2720	vancomycin resistance protein
CLM_0963	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLM_0969	COG0720	synthase
CLM_0970	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLM_0973	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLM_0973	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLM_0974	COG0071	Belongs to the small heat shock protein (HSP20) family
CLM_0975	COG0789	Transcriptional regulator
CLM_0976	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLM_0979	COG1595	DNA-templated transcription, initiation
CLM_0984	COG1131	(ABC) transporter
CLM_0986	COG3620	sequence-specific DNA binding
CLM_0988	COG2267	carboxylic ester hydrolase activity
CLM_0997	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CLM_0997	COG0456	acetyltransferase
CLM_0999	COG1741	Belongs to the pirin family
CLM_1000	COG1733	regulation of RNA biosynthetic process
CLM_1001	COG0778	Nitroreductase
CLM_1003	COG2140	Oxalate decarboxylase
CLM_1004	COG1611	Belongs to the LOG family
CLM_1006	COG0583	DNA-binding transcription factor activity
CLM_1007	COG0519	Catalyzes the synthesis of GMP from XMP
CLM_1011	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_1012	COG0778	Nitroreductase
CLM_1017	COG3708	Transcriptional regulator
CLM_1017	COG2207	Transcriptional regulator
CLM_1020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_1020	COG1263	PTS System
CLM_1020	COG2190	(PTS) system
CLM_1021	COG2723	6-phospho-beta-galactosidase activity
CLM_1029	COG2207	Transcriptional regulator
CLM_1038	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CLM_1040	COG1376	ErfK ybiS ycfS ynhG family protein
CLM_1048	COG1136	(ABC) transporter
CLM_1048	COG0577	efflux transmembrane transporter activity
CLM_1050	COG5002	protein histidine kinase activity
CLM_1051	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLM_1052	COG1268	BioY protein
CLM_1054	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLM_1055	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLM_1058	COG0789	Transcriptional regulator
CLM_1061	COG1492	cobalamin metabolic process
CLM_1062	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CLM_1063	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLM_1067	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLM_1067	COG1648	precorrin-2 dehydrogenase activity
CLM_1068	COG0181	hydroxymethylbilane synthase activity
CLM_1071	COG0113	porphobilinogen synthase activity
CLM_1077	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM_1079	COG0454	-acetyltransferase
CLM_1080	COG3177	Filamentation induced by cAMP protein fic
CLM_1081	COG0778	Nitroreductase
CLM_1085	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CLM_1085	COG0456	acetyltransferase
CLM_1086	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLM_1097	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLM_1097	COG1648	precorrin-2 dehydrogenase activity
CLM_1098	COG2875	Belongs to the precorrin methyltransferase family
CLM_1105	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLM_1107	COG2116	formate transmembrane transporter activity
CLM_1110	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLM_1116	COG0745	RESPONSE REGULATOR receiver
CLM_1117	COG2205	protein histidine kinase activity
CLM_1118	COG1120	ATPase activity
CLM_1119	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM_1120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLM_1123	COG1011	Hydrolase
CLM_1126	COG0583	DNA-binding transcription factor activity
CLM_1131	COG2376	Dihydroxyacetone kinase
CLM_1133	COG2207	Transcriptional regulator
CLM_1133	COG0662	Cupin 2, conserved barrel domain protein
CLM_1134	COG0454	-acetyltransferase
CLM_1138	COG0656	L-ascorbic acid biosynthetic process
CLM_1144	COG0791	NLP P60 protein
CLM_1145	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CLM_1150	COG0514	ATP-dependent DNA helicase (RecQ)
CLM_1151	COG1773	rubredoxin
CLM_1151	COG1592	Rubrerythrin
CLM_1152	COG0622	Phosphoesterase
CLM_1153	COG0745	RESPONSE REGULATOR receiver
CLM_1157	COG0602	queuosine metabolic process
CLM_1160	COG1620	l-lactate permease
CLM_1161	COG3875	lactate racemase activity
CLM_1162	COG2086	electron transfer activity
CLM_1163	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLM_1164	COG0277	FAD linked oxidase domain protein
CLM_1169	COG0436	Aminotransferase
CLM_1171	COG1846	Transcriptional regulator
CLM_1172	COG0789	Transcriptional regulator
CLM_1172	COG4978	Transcriptional regulator
CLM_1174	COG0017	Asparaginyl-tRNA synthetase
CLM_1179	COG1011	Hydrolase
CLM_1182	COG0583	DNA-binding transcription factor activity
CLM_1183	COG0456	acetyltransferase
CLM_1185	COG1918	ferrous iron import across plasma membrane
CLM_1185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLM_1189	COG1876	peptidase activity
CLM_1192	COG5002	protein histidine kinase activity
CLM_1194	COG2124	cytochrome p450
CLM_1197	COG0745	RESPONSE REGULATOR receiver
CLM_1198	COG5002	protein histidine kinase activity
CLM_1201	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM_1202	COG4605	iron ion homeostasis
CLM_1203	COG4604	ABC transporter, ATP-binding protein
CLM_1204	COG4607	ABC-type enterochelin transport system periplasmic component
CLM_1205	COG2207	Transcriptional regulator
CLM_1206	COG1132	(ABC) transporter
CLM_1207	COG1132	(ABC) transporter
CLM_1209	COG3279	Response regulator of the LytR AlgR family
CLM_1215	COG1331	Highly conserved protein containing a thioredoxin domain
CLM_1216	COG4129	membrane
CLM_1224	COG0488	(ABC) transporter
CLM_1229	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLM_1231	COG2271	Major facilitator Superfamily
CLM_1232	COG0018	arginyl-trna synthetase
CLM_1233	COG0436	Aminotransferase
CLM_1240	COG3979	chitinase
CLM_1243	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLM_1244	COG2011	ABC-type metal ion transport system permease component
CLM_1245	COG1464	Belongs to the NlpA lipoprotein family
CLM_1246	COG1464	Belongs to the NlpA lipoprotein family
CLM_1247	COG1473	amidohydrolase
CLM_1249	COG2186	Transcriptional regulator
CLM_1250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLM_1254	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CLM_1256	COG0617	tRNA 3'-terminal CCA addition
CLM_1257	COG1012	belongs to the aldehyde dehydrogenase family
CLM_1258	COG1115	amino acid carrier protein
CLM_1259	COG1115	amino acid carrier protein
CLM_1260	COG1846	Transcriptional regulator
CLM_1261	COG0534	Mate efflux family protein
CLM_1264	COG4134	Bacterial extracellular solute-binding protein
CLM_1267	COG1176	ABC-type spermidine putrescine transport system, permease component I
CLM_1270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLM_1273	COG2431	L-lysine efflux transmembrane transporter activity
CLM_1274	COG0110	maltose O-acetyltransferase activity
CLM_1278	COG5002	protein histidine kinase activity
CLM_1281	COG2239	Acts as a magnesium transporter
CLM_1283	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLM_1287	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CLM_1290	COG1335	isochorismatase
CLM_1297	COG2897	thiosulfate sulfurtransferase activity
CLM_1299	COG0628	permease
CLM_1310	COG0539	negative regulation of cytoplasmic translation
CLM_1310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLM_1311	COG0824	Thioesterase
CLM_1314	COG4120	Belongs to the binding-protein-dependent transport system permease family
CLM_1315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLM_1318	COG0697	spore germination
CLM_1319	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM_1321	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLM_1322	COG3404	Formiminotransferase-cyclodeaminase
CLM_1323	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLM_1324	COG0561	phosphatase activity
CLM_1329	COG1959	2 iron, 2 sulfur cluster binding
CLM_1334	COG1606	tRNA processing
CLM_1340	COG3290	protein histidine kinase activity
CLM_1343	COG0584	glycerophosphoryl diester phosphodiesterase
CLM_1348	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CLM_1349	COG1231	oxidoreductase activity
CLM_1354	COG1940	carbohydrate kinase activity
CLM_1358	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLM_1360	COG1131	(ABC) transporter
CLM_1368	COG3300	MHYT domain
CLM_1368	COG5001	Diguanylate cyclase
CLM_1370	COG1760	l-serine dehydratase
CLM_1375	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CLM_1378	COG0577	efflux transmembrane transporter activity
CLM_1378	COG1136	(ABC) transporter
CLM_1380	COG1136	(ABC) transporter
CLM_1381	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLM_1382	COG0601	transmembrane transport
CLM_1386	COG3546	catalase activity
CLM_1387	COG5434	Belongs to the glycosyl hydrolase 28 family
CLM_1387	COG4632	Exopolysaccharide biosynthesis protein
CLM_1391	COG0756	dUTP diphosphatase activity
CLM_1398	COG1309	transcriptional regulator
CLM_1400	COG1131	(ABC) transporter
CLM_1404	COG1115	amino acid carrier protein
CLM_1406	COG1395	domain, Protein
CLM_1411	COG1012	belongs to the aldehyde dehydrogenase family
CLM_1426	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CLM_1429	COG0235	Class ii aldolase
CLM_1430	COG1349	DNA-binding transcription factor activity
CLM_1432	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLM_1433	COG2323	membrane
CLM_1444	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLM_1445	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CLM_1446	COG2080	2 iron, 2 sulfur cluster binding
CLM_1447	COG0590	tRNA wobble adenosine to inosine editing
CLM_1453	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLM_1454	COG1115	amino acid carrier protein
CLM_1456	COG5298	Protein conserved in bacteria
CLM_1457	COG1215	transferase activity, transferring glycosyl groups
CLM_1462	COG1937	Protein conserved in bacteria
CLM_1463	COG2217	Heavy metal translocating P-type atpase
CLM_1464	COG2608	mercury ion transmembrane transporter activity
CLM_1465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLM_1466	COG1132	(ABC) transporter
CLM_1470	COG5002	protein histidine kinase activity
CLM_1491	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLM_1493	COG0569	domain protein
CLM_1495	COG0210	DNA helicase
CLM_1495	COG0210	DNA helicase
CLM_1497	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_1498	COG3773	Cell wall hydrolase
CLM_1498	COG3409	Peptidoglycan-binding domain 1 protein
CLM_1501	COG2247	cell wall binding repeat
CLM_1501	COG2385	sporulation resulting in formation of a cellular spore
CLM_1502	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_1502	COG2190	(PTS) system
CLM_1502	COG1263	PTS System
CLM_1503	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLM_1506	COG1151	hydroxylamine reductase activity
CLM_1508	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLM_1510	COG1132	(ABC) transporter
CLM_1512	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM_1514	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLM_1515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLM_1516	COG1120	ATPase activity
CLM_1518	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
CLM_1519	COG1737	Transcriptional regulator
CLM_1521	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_1521	COG1263	PTS System
CLM_1529	COG5278	phosphoserine phosphatase activity
CLM_1529	COG0840	transmembrane signaling receptor activity
CLM_1531	COG0601	transmembrane transport
CLM_1532	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLM_1533	COG0444	Belongs to the ABC transporter superfamily
CLM_1534	COG4608	Belongs to the ABC transporter superfamily
CLM_1536	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLM_1537	COG1121	(ABC) transporter
CLM_1538	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLM_1541	COG3706	GGDEF domain
CLM_1544	COG1116	anion transmembrane transporter activity
CLM_1545	COG0735	belongs to the Fur family
CLM_1549	COG1234	tRNA 3'-trailer cleavage
CLM_1550	COG0531	amino acid
CLM_1552	COG4585	Histidine kinase
CLM_1553	COG2197	response regulator
CLM_1554	COG1131	(ABC) transporter
CLM_1561	COG1278	Cold shock
CLM_1562	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLM_1565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLM_1566	COG1136	(ABC) transporter
CLM_1567	COG0577	efflux transmembrane transporter activity
CLM_1569	COG0745	RESPONSE REGULATOR receiver
CLM_1570	COG2205	protein histidine kinase activity
CLM_1571	COG1136	(ABC) transporter
CLM_1572	COG0577	efflux transmembrane transporter activity
CLM_1576	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLM_1579	COG1126	abc transporter atp-binding protein
CLM_1581	COG1686	Belongs to the peptidase S11 family
CLM_1582	COG0494	nUDIX hydrolase
CLM_1584	COG1979	alcohol dehydrogenase
CLM_1586	COG1288	antiporter activity
CLM_1587	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLM_1588	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLM_1593	COG0849	cell division
CLM_1594	COG1473	amidohydrolase
CLM_1595	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLM_1596	COG0564	pseudouridine synthase activity
CLM_1597	COG2244	polysaccharide biosynthetic process
CLM_1602	COG1067	ATP-dependent peptidase activity
CLM_1610	COG0157	Belongs to the NadC ModD family
CLM_1614	COG0582	viral genome integration into host DNA
CLM_1619	COG3645	SOS response
CLM_1619	COG3646	Phage regulatory protein
CLM_1658	COG0740	serine-type endopeptidase activity
CLM_1675	COG3299	homolog of phage Mu protein gp47
CLM_1688	COG1272	protein, Hemolysin III
CLM_1689	COG0012	GTP binding
CLM_1690	COG2001	Belongs to the MraZ family
CLM_1691	COG0275	rRNA processing
CLM_1693	COG0768	penicillin binding
CLM_1695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLM_1697	COG0772	Belongs to the SEDS family
CLM_1700	COG3856	small basic protein
CLM_1702	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLM_1706	COG3599	regulation of cell shape
CLM_1708	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLM_1709	COG1605	Chorismate mutase
CLM_1709	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLM_1711	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLM_1712	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLM_1713	COG0564	pseudouridine synthase activity
CLM_1715	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLM_1716	COG2233	PERMEase
CLM_1718	COG0708	Exodeoxyribonuclease III
CLM_1719	COG0116	Belongs to the methyltransferase superfamily
CLM_1721	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLM_1722	COG4149	molybdate abc transporter
CLM_1723	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLM_1725	COG1752	Esterase of the alpha-beta hydrolase superfamily
CLM_1727	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLM_1728	COG1757	Na H antiporter
CLM_1730	COG0523	cobalamin synthesis protein
CLM_1732	COG5012	cobalamin binding
CLM_1733	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLM_1735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLM_1736	COG2011	ABC-type metal ion transport system permease component
CLM_1737	COG1464	Belongs to the NlpA lipoprotein family
CLM_1739	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLM_1739	COG1902	pentaerythritol trinitrate reductase activity
CLM_1741	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLM_1741	COG0723	plastoquinol--plastocyanin reductase activity
CLM_1742	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLM_1742	COG0551	DNA topoisomerase type I activity
CLM_1743	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLM_1744	COG0667	Aldo Keto reductase
CLM_1745	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CLM_1748	COG1309	transcriptional regulator
CLM_1750	COG3842	ATPase activity
CLM_1752	COG0395	ABC-type sugar transport system, permease component
CLM_1754	COG0039	L-malate dehydrogenase activity
CLM_1755	COG2186	Transcriptional regulator
CLM_1761	COG0840	transmembrane signaling receptor activity
CLM_1764	COG1733	regulation of RNA biosynthetic process
CLM_1766	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLM_1767	COG5564	TIM-barrel signal transduction protein
CLM_1769	COG5564	TIM-barrel signal transduction protein
CLM_1773	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLM_1777	COG1639	'signal transduction protein
CLM_1780	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLM_1788	COG2197	response regulator
CLM_1791	COG2378	regulation of single-species biofilm formation
CLM_1794	COG1924	4 iron, 4 sulfur cluster binding
CLM_1795	COG0720	synthase
CLM_1796	COG0602	queuosine metabolic process
CLM_1797	COG0302	gtp cyclohydrolase
CLM_1798	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLM_1803	COG2390	Transcriptional regulator
CLM_1804	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLM_1805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM_1806	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CLM_1808	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLM_1809	COG0131	Imidazoleglycerol-phosphate dehydratase
CLM_1810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLM_1811	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLM_1812	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLM_1813	COG0107	imidazoleglycerol-phosphate synthase activity
CLM_1814	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLM_1815	COG0140	phosphoribosyl-ATP diphosphatase activity
CLM_1816	COG2391	methyltransferase activity
CLM_1818	COG2391	methyltransferase activity
CLM_1819	COG0583	DNA-binding transcription factor activity
CLM_1821	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLM_1822	COG2391	methyltransferase activity
CLM_1828	COG2235	arginine
CLM_1841	COG2207	Transcriptional regulator
CLM_1841	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLM_1842	COG1132	(ABC) transporter
CLM_1843	COG1132	(ABC) transporter
CLM_1844	COG1609	Transcriptional regulator
CLM_1845	COG1940	carbohydrate kinase activity
CLM_1846	COG0366	Alpha amylase catalytic
CLM_1847	COG1263	PTS System
CLM_1847	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_1847	COG2190	(PTS) system
CLM_1850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLM_1853	COG2205	protein histidine kinase activity
CLM_1857	COG0561	phosphatase activity
CLM_1858	COG1349	DNA-binding transcription factor activity
CLM_1863	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLM_1865	COG1410	methionine synthase
CLM_1865	COG0646	methionine synthase
CLM_1871	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CLM_1872	COG0022	dehydrogenase e1 component
CLM_1873	COG3199	ATP-NAD kinase
CLM_1874	COG0508	dehydrogenase complex catalyzes the overall conversion of
CLM_1875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CLM_1876	COG0095	Lipoate-protein ligase
CLM_1878	COG1174	glycine betaine transport
CLM_1879	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLM_1880	COG0083	homoserine kinase activity
CLM_1881	COG0527	aspartate kinase activity
CLM_1882	COG0460	homoserine dehydrogenase
CLM_1886	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLM_1886	COG0493	'glutamate synthase
CLM_1889	COG5492	domain, Protein
CLM_1900	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLM_1901	COG0840	transmembrane signaling receptor activity
CLM_1904	COG1028	Short-chain dehydrogenase reductase Sdr
CLM_1905	COG0840	transmembrane signaling receptor activity
CLM_1908	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLM_1913	COG0601	transmembrane transport
CLM_1916	COG1199	ATP-dependent helicase activity
CLM_1916	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLM_1917	COG4086	secreted protein
CLM_1919	COG0071	Belongs to the small heat shock protein (HSP20) family
CLM_1920	COG2814	Major facilitator Superfamily
CLM_1921	COG1309	transcriptional regulator
CLM_1923	COG1105	Belongs to the carbohydrate kinase PfkB family
CLM_1924	COG3104	oligopeptide transport
CLM_1929	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLM_1930	COG2340	Cysteine-rich secretory protein family
CLM_1933	COG0488	(ABC) transporter
CLM_1934	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLM_1935	COG0835	chemotaxis
CLM_1935	COG0784	Response regulator, receiver
CLM_1937	COG2996	Protein conserved in bacteria
CLM_1941	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLM_1942	COG1528	Iron-storage protein
CLM_1943	COG2201	protein-glutamate methylesterase activity
CLM_1950	COG4974	Belongs to the 'phage' integrase family
CLM_1953	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLM_1955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLM_1956	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLM_1957	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLM_1959	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_1961	COG0436	Aminotransferase
CLM_1967	COG2081	HI0933 family
CLM_1969	COG1737	Transcriptional regulator
CLM_1970	COG1187	pseudouridine synthase activity
CLM_1973	COG1215	transferase activity, transferring glycosyl groups
CLM_1975	COG0840	transmembrane signaling receptor activity
CLM_1976	COG4232	protein-disulfide reductase activity
CLM_1978	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLM_1980	COG0569	domain protein
CLM_1980	COG0475	glutathione-regulated potassium exporter activity
CLM_1981	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CLM_1984	COG0393	Putative heavy-metal-binding
CLM_1986	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CLM_1990	COG0309	Hydrogenase expression formation protein (HypE)
CLM_1991	COG0409	Hydrogenase expression formation protein
CLM_1992	COG0298	carbon dioxide binding
CLM_1993	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CLM_2001	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLM_2006	COG0488	(ABC) transporter
CLM_2010	COG0475	glutathione-regulated potassium exporter activity
CLM_2010	COG0589	response to stress
CLM_2012	COG0628	permease
CLM_2013	COG1686	Belongs to the peptidase S11 family
CLM_2015	COG3874	Sporulation protein YtfJ
CLM_2016	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLM_2017	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CLM_2020	COG1686	Belongs to the peptidase S11 family
CLM_2024	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CLM_2025	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CLM_2026	COG4974	Belongs to the 'phage' integrase family
CLM_2031	COG0531	amino acid
CLM_2087	COG4974	Belongs to the 'phage' integrase family
CLM_2088	COG0745	RESPONSE REGULATOR receiver
CLM_2089	COG0750	zinc metalloprotease
CLM_2090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLM_2091	COG0460	homoserine dehydrogenase
CLM_2094	COG0497	DNA recombination
CLM_2096	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLM_2097	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLM_2101	COG1722	exodeoxyribonuclease VII activity
CLM_2102	COG1570	exodeoxyribonuclease VII activity
CLM_2103	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLM_2112	COG3854	ATPases associated with a variety of cellular activities
CLM_2115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLM_2116	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLM_2124	COG2165	general secretion pathway protein
CLM_2126	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLM_2134	COG0076	glutamate decarboxylase activity
CLM_2136	COG0840	transmembrane signaling receptor activity
CLM_2140	COG5002	protein histidine kinase activity
CLM_2141	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CLM_2142	COG5002	protein histidine kinase activity
CLM_2146	COG1131	(ABC) transporter
CLM_2148	COG1132	(ABC) transporter
CLM_2153	COG2414	aldehyde ferredoxin oxidoreductase
CLM_2156	COG0315	cyclic pyranopterin monophosphate synthase activity
CLM_2158	COG0303	'Molybdopterin
CLM_2159	COG0303	'Molybdopterin
CLM_2160	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLM_2164	COG0534	Mate efflux family protein
CLM_2167	COG1136	(ABC) transporter
CLM_2168	COG0577	efflux transmembrane transporter activity
CLM_2170	COG1132	(ABC) transporter
CLM_2172	COG0789	Transcriptional regulator
CLM_2172	COG4978	Transcriptional regulator
CLM_2178	COG4545	Glutaredoxin-related protein
CLM_2179	COG0251	oxidation-reduction process
CLM_2180	COG1301	dicarboxylic acid transport
CLM_2181	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CLM_2185	COG5002	protein histidine kinase activity
CLM_2186	COG0745	RESPONSE REGULATOR receiver
CLM_2188	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLM_2189	COG4172	Belongs to the ABC transporter superfamily
CLM_2191	COG3457	Alanine racemase
CLM_2193	COG0697	spore germination
CLM_2194	COG0814	amino acid
CLM_2201	COG3263	regulation of cellular component size
CLM_2202	COG0326	Molecular chaperone. Has ATPase activity
CLM_2203	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLM_2204	COG1263	PTS System
CLM_2204	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_2205	COG0366	Alpha amylase catalytic
CLM_2206	COG2188	Transcriptional regulator
CLM_2207	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLM_2207	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLM_2207	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM_2208	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLM_2208	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLM_2208	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM_2209	COG1105	Belongs to the carbohydrate kinase PfkB family
CLM_2217	COG0840	transmembrane signaling receptor activity
CLM_2219	COG3457	Alanine racemase
CLM_2221	COG0673	inositol 2-dehydrogenase activity
CLM_2222	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLM_2225	COG3706	GGDEF domain
CLM_2229	COG2340	Cysteine-rich secretory protein family
CLM_2230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_2231	COG0697	spore germination
CLM_2232	COG0436	Aminotransferase
CLM_2233	COG1126	abc transporter atp-binding protein
CLM_2235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLM_2236	COG3875	lactate racemase activity
CLM_2237	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLM_2243	COG3104	oligopeptide transport
CLM_2244	COG3104	oligopeptide transport
CLM_2245	COG0006	proline dipeptidase activity
CLM_2248	COG0733	neurotransmitter:sodium symporter activity
CLM_2249	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_2254	COG2304	oxidoreductase activity
CLM_2256	COG0714	Associated with various cellular activities
CLM_2257	COG4716	Myosin-crossreactive antigen
CLM_2262	COG0840	transmembrane signaling receptor activity
CLM_2268	COG1045	serine acetyltransferase
CLM_2279	COG1819	glycosyl
CLM_2293	COG4443	Transcriptional Coactivator p15 (PC4)
CLM_2296	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CLM_2298	COG1204	response to ionizing radiation
CLM_2304	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLM_2305	COG1215	transferase activity, transferring glycosyl groups
CLM_2306	COG1216	Glycosyl transferase, family 2
CLM_2314	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLM_2315	COG4869	propanediol catabolic process
CLM_2316	COG1454	alcohol dehydrogenase
CLM_2316	COG1012	belongs to the aldehyde dehydrogenase family
CLM_2317	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLM_2321	COG4820	ethanolamine utilization protein (EutJ)
CLM_2324	COG4810	utilization protein
CLM_2325	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLM_2326	COG1882	Formate acetyltransferase
CLM_2327	COG1454	alcohol dehydrogenase
CLM_2327	COG1012	belongs to the aldehyde dehydrogenase family
CLM_2328	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLM_2329	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
CLM_2332	COG0789	Transcriptional regulator
CLM_2335	COG2807	transmembrane transport
CLM_2336	COG2186	Transcriptional regulator
CLM_2341	COG3878	Protein conserved in bacteria
CLM_2344	COG3764	Sortase (surface protein transpeptidase)
CLM_2347	COG0745	RESPONSE REGULATOR receiver
CLM_2351	COG0577	efflux transmembrane transporter activity
CLM_2353	COG3655	Transcriptional regulator
CLM_2355	COG1063	alcohol dehydrogenase
CLM_2358	COG0577	efflux transmembrane transporter activity
CLM_2359	COG1136	(ABC) transporter
CLM_2361	COG3711	transcriptional antiterminator
CLM_2361	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM_2364	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM_2365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLM_2369	COG0110	maltose O-acetyltransferase activity
CLM_2372	COG3104	oligopeptide transport
CLM_2373	COG2226	methyltransferase
CLM_2374	COG3708	Transcriptional regulator
CLM_2374	COG2207	Transcriptional regulator
CLM_2382	COG0384	phenazine biosynthesis protein PhzF
CLM_2383	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_2385	COG1396	sequence-specific DNA binding
CLM_2387	COG0402	S-adenosylhomocysteine deaminase activity
CLM_2388	COG2233	PERMEase
CLM_2391	COG0531	amino acid
CLM_2395	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLM_2396	COG2086	electron transfer activity
CLM_2397	COG1960	acyl-CoA dehydrogenase activity
CLM_2404	COG0840	transmembrane signaling receptor activity
CLM_2407	COG0346	lactoylglutathione lyase activity
CLM_2408	COG2610	gluconate transmembrane transporter activity
CLM_2410	COG3395	kinase activity
CLM_2411	COG1349	DNA-binding transcription factor activity
CLM_2419	COG5599	Phosphatase
CLM_2420	COG1063	alcohol dehydrogenase
CLM_2421	COG1151	hydroxylamine reductase activity
CLM_2424	COG0375	protein maturation
CLM_2425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CLM_2428	COG0489	protein tyrosine kinase activity
CLM_2431	COG1360	Flagellar Motor Protein
CLM_2432	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLM_2434	COG2247	cell wall binding repeat
CLM_2434	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLM_2437	COG1297	OPT oligopeptide transporter protein
CLM_2438	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLM_2440	COG1929	Belongs to the glycerate kinase type-1 family
CLM_2443	COG1028	Short-chain dehydrogenase reductase Sdr
CLM_2444	COG1668	transmembrane transport
CLM_2445	COG4555	ABC transporter
CLM_2446	COG2153	protein acetylation
CLM_2447	COG1846	Transcriptional regulator
CLM_2449	COG2205	protein histidine kinase activity
CLM_2451	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CLM_2453	COG0531	amino acid
CLM_2460	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLM_2465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM_2467	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CLM_2469	COG1268	BioY protein
CLM_2472	COG0006	proline dipeptidase activity
CLM_2473	COG3104	oligopeptide transport
CLM_2529	COG1783	phage Terminase large subunit
CLM_2530	COG5484	DNA packaging
CLM_2533	COG5492	domain, Protein
CLM_2540	COG4974	Belongs to the 'phage' integrase family
CLM_2558	COG2002	toxin-antitoxin pair type II binding
CLM_2562	COG1484	DNA-dependent DNA replication
CLM_2573	COG3561	AntA/AntB antirepressor
CLM_2576	COG2856	Zn peptidase
CLM_2584	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLM_2585	COG1132	(ABC) transporter
CLM_2586	COG1132	(ABC) transporter
CLM_2592	COG2205	protein histidine kinase activity
CLM_2593	COG0745	RESPONSE REGULATOR receiver
CLM_2597	COG0242	peptide deformylase activity
CLM_2602	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
CLM_2622	COG5002	protein histidine kinase activity
CLM_2622	COG3850	Histidine kinase
CLM_2623	COG0745	RESPONSE REGULATOR receiver
CLM_2626	COG1484	DNA-dependent DNA replication
CLM_2628	COG1396	sequence-specific DNA binding
CLM_2641	COG3299	homolog of phage Mu protein gp47
CLM_2664	COG3728	DNA packaging
CLM_2670	COG0194	GDP metabolic process
CLM_2687	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CLM_2689	COG2155	Conserved Protein
CLM_2690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLM_2691	COG0436	Aminotransferase
CLM_2692	COG2076	Multidrug Resistance protein
CLM_2694	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CLM_2695	COG2359	stage V sporulation protein S
CLM_2698	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLM_2700	COG1674	ftsk spoiiie
CLM_2701	COG0740	serine-type endopeptidase activity
CLM_2702	COG0527	aspartate kinase activity
CLM_2704	COG0612	Peptidase, M16
CLM_2705	COG1185	polyribonucleotide nucleotidyltransferase activity
CLM_2707	COG0196	riboflavin kinase activity
CLM_2709	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CLM_2711	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLM_2712	COG1358	cellular component organization or biogenesis
CLM_2713	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLM_2714	COG0195	Participates in both transcription termination and antitermination
CLM_2715	COG0779	Required for maturation of 30S ribosomal subunits
CLM_2717	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLM_2718	COG0750	zinc metalloprotease
CLM_2719	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLM_2723	COG4589	Belongs to the CDS family
CLM_2730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLM_2731	COG0758	DNA mediated transformation
CLM_2732	COG0606	chelatase, subunit chli
CLM_2733	COG0792	nuclease activity
CLM_2735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CLM_2736	COG0681	Belongs to the peptidase S26 family
CLM_2738	COG0336	Belongs to the RNA methyltransferase TrmD family
CLM_2740	COG1837	Belongs to the UPF0109 family
CLM_2741	COG0228	four-way junction DNA binding
CLM_2742	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLM_2744	COG0552	protein localization to endoplasmic reticulum
CLM_2749	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLM_2751	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLM_2752	COG1399	metal-binding, possibly nucleic acid-binding protein
CLM_2753	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLM_2754	COG0280	phosphate acetyltransferase
CLM_2759	COG5275	peptidyl-tyrosine sulfation
CLM_2759	COG0252	asparaginase activity
CLM_2763	COG0840	transmembrane signaling receptor activity
CLM_2768	COG0531	amino acid
CLM_2776	COG0252	asparaginase activity
CLM_2776	COG5275	peptidyl-tyrosine sulfation
CLM_2778	COG4656	Part of a membrane complex involved in electron transport
CLM_2779	COG5275	peptidyl-tyrosine sulfation
CLM_2779	COG0252	asparaginase activity
CLM_2780	COG4656	Part of a membrane complex involved in electron transport
CLM_2787	COG5275	peptidyl-tyrosine sulfation
CLM_2787	COG0252	asparaginase activity
CLM_2788	COG4656	Part of a membrane complex involved in electron transport
CLM_2789	COG3829	transcription factor binding
CLM_2789	COG3290	protein histidine kinase activity
CLM_2790	COG1323	Belongs to the UPF0348 family
CLM_2794	COG0742	ribosomal rna small subunit methyltransferase
CLM_2795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLM_2796	COG1461	Dihydroxyacetone kinase
CLM_2797	COG1302	Protein conserved in bacteria
CLM_2802	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLM_2803	COG1162	GTPase activity
CLM_2804	COG2815	serine threonine protein kinase
CLM_2804	COG0515	serine threonine protein kinase
CLM_2805	COG0631	protein serine/threonine phosphatase activity
CLM_2807	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLM_2807	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLM_2808	COG2738	Putative neutral zinc metallopeptidase
CLM_2810	COG0242	peptide deformylase activity
CLM_2811	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLM_2812	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLM_2814	COG0194	GDP metabolic process
CLM_2816	COG1561	YicC-like family, N-terminal region
CLM_2824	COG1160	GTP binding
CLM_2826	COG0704	Plays a role in the regulation of phosphate uptake
CLM_2827	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLM_2828	COG0581	inorganic phosphate transmembrane transporter activity
CLM_2829	COG0573	inorganic phosphate transmembrane transporter activity
CLM_2830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLM_2831	COG5002	protein histidine kinase activity
CLM_2832	COG0745	RESPONSE REGULATOR receiver
CLM_2835	COG1873	PFAM PRC-barrel domain
CLM_2836	COG1191	sigma factor activity
CLM_2837	COG1191	sigma factor activity
CLM_2839	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLM_2840	COG0849	cell division
CLM_2841	COG1215	transferase activity, transferring glycosyl groups
CLM_2845	COG1191	sigma factor activity
CLM_2850	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
CLM_2860	COG0768	penicillin binding
CLM_2861	COG0572	uridine kinase
CLM_2864	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLM_2866	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLM_2867	COG0735	belongs to the Fur family
CLM_2872	COG0628	permease
CLM_2874	COG0822	iron-sulfur transferase activity
CLM_2875	COG1104	cysteine desulfurase activity
CLM_2876	COG1959	2 iron, 2 sulfur cluster binding
CLM_2877	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLM_2878	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLM_2883	COG1115	amino acid carrier protein
CLM_2884	COG1115	amino acid carrier protein
CLM_2887	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLM_2889	COG0574	Belongs to the PEP-utilizing enzyme family
CLM_2889	COG3848	Pyruvate phosphate dikinase
CLM_2892	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM_2900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLM_2902	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLM_2903	COG2966	Psort location CytoplasmicMembrane, score
CLM_2905	COG1937	Protein conserved in bacteria
CLM_2906	COG0561	phosphatase activity
CLM_2909	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLM_2910	COG0039	L-malate dehydrogenase activity
CLM_2912	COG0613	PHP domain protein
CLM_2935	COG4626	Terminase
CLM_2935	COG1802	Transcriptional regulator
CLM_2966	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CLM_2967	COG1362	aminopeptidase activity
CLM_2968	COG0598	Magnesium transport protein CorA
CLM_2969	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLM_2971	COG4224	UPF0291 protein
CLM_2972	COG0398	Pfam SNARE associated Golgi protein
CLM_2973	COG0398	Pfam SNARE associated Golgi protein
CLM_2977	COG0463	Glycosyl transferase, family 2
CLM_2978	COG2897	thiosulfate sulfurtransferase activity
CLM_2979	COG1494	fructose-1,6-bisphosphatase
CLM_2982	COG0426	domain, Protein
CLM_2988	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CLM_2992	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CLM_2993	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLM_2994	COG1269	ATP hydrolysis coupled proton transport
CLM_3000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLM_3004	COG4786	Flagellar basal body rod
CLM_3007	COG1191	sigma factor activity
CLM_3009	COG0455	bacterial-type flagellum organization
CLM_3010	COG1419	protein localization to endoplasmic reticulum
CLM_3011	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLM_3012	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLM_3014	COG1338	Plays a role in the flagellum-specific transport system
CLM_3016	COG1580	Controls the rotational direction of flagella during chemotaxis
CLM_3019	COG1582	Flagellar protein (FlbD)
CLM_3020	COG4786	Flagellar basal body rod
CLM_3022	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLM_3025	COG1157	protein secretion by the type III secretion system
CLM_3027	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLM_3028	COG1766	The M ring may be actively involved in energy transduction
CLM_3029	COG1677	Flagellar hook-basal body complex protein FliE
CLM_3030	COG1558	bacterial-type flagellum-dependent cell motility
CLM_3031	COG1815	bacterial-type flagellum-dependent cell motility
CLM_3032	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM_3034	COG0165	Argininosuccinate lyase
CLM_3035	COG0137	argininosuccinate synthase activity
CLM_3038	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CLM_3039	COG4129	membrane
CLM_3044	COG2089	acid synthase
CLM_3045	COG1083	cytidylyl-transferase
CLM_3049	COG0562	UDP-galactopyranose mutase
CLM_3051	COG0489	protein tyrosine kinase activity
CLM_3052	COG4464	protein tyrosine phosphatase activity
CLM_3053	COG3944	biosynthesis protein
CLM_3059	COG0840	transmembrane signaling receptor activity
CLM_3060	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM_3064	COG3980	spore coat polysaccharide biosynthesis protein
CLM_3067	COG1216	Glycosyl transferase, family 2
CLM_3079	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CLM_3081	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLM_3084	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLM_3086	COG2089	acid synthase
CLM_3087	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLM_3089	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLM_3090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLM_3091	COG1086	Polysaccharide biosynthesis protein
CLM_3092	COG0463	Glycosyl transferase, family 2
CLM_3092	COG0457	Tetratricopeptide repeat
CLM_3096	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM_3097	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLM_3099	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLM_3100	COG1516	flagellar protein fliS
CLM_3106	COG1256	bacterial-type flagellum assembly
CLM_3106	COG4786	Flagellar basal body rod
CLM_3109	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLM_3109	COG1776	CheC inhibitor of MCP methylation
CLM_3110	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLM_3111	COG0835	chemotaxis
CLM_3112	COG2201	protein-glutamate methylesterase activity
CLM_3113	COG1776	CheC inhibitor of MCP methylation
CLM_3114	COG2198	Histidine kinase
CLM_3114	COG0643	Histidine kinase
CLM_3115	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLM_3116	COG2201	protein-glutamate methylesterase activity
CLM_3120	COG1263	PTS System
CLM_3120	COG2190	(PTS) system
CLM_3120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_3121	COG3711	transcriptional antiterminator
CLM_3127	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLM_3129	COG5002	protein histidine kinase activity
CLM_3130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLM_3130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLM_3132	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLM_3136	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CLM_3137	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLM_3138	COG0187	DNA topoisomerase II activity
CLM_3145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLM_3148	COG2207	Transcriptional regulator
CLM_3149	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLM_3150	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLM_3151	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLM_3155	COG1131	(ABC) transporter
CLM_3156	COG1725	Transcriptional regulator
CLM_3158	COG1151	hydroxylamine reductase activity
CLM_3162	COG0814	amino acid
CLM_3163	COG0697	spore germination
CLM_3166	COG0513	Belongs to the DEAD box helicase family
CLM_3169	COG3290	protein histidine kinase activity
CLM_3169	COG0840	transmembrane signaling receptor activity
CLM_3173	COG2066	Belongs to the glutaminase family
CLM_3174	COG1388	LysM domain
CLM_3174	COG3584	3D domain protein
CLM_3175	COG0840	transmembrane signaling receptor activity
CLM_3177	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLM_3178	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLM_3181	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLM_3183	COG0493	'glutamate synthase
CLM_3184	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLM_3189	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CLM_3191	COG0840	transmembrane signaling receptor activity
CLM_3194	COG0735	belongs to the Fur family
CLM_3198	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLM_3200	COG3711	transcriptional antiterminator
CLM_3202	COG1263	PTS System
CLM_3202	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLM_3203	COG0534	Mate efflux family protein
CLM_3204	COG0719	Fe-S assembly protein
CLM_3205	COG3842	ATPase activity
CLM_3207	COG0735	belongs to the Fur family
CLM_3208	COG0534	Mate efflux family protein
CLM_3209	COG1773	rubredoxin
CLM_3209	COG0426	domain, Protein
CLM_3210	COG1960	acyl-CoA dehydrogenase activity
CLM_3211	COG2801	Transposase and inactivated derivatives
CLM_3215	COG3715	PTS system
CLM_3216	COG3716	PTS system mannose fructose sorbose family IID component
CLM_3218	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CLM_3220	COG2068	MobA-Related Protein
CLM_3221	COG2080	2 iron, 2 sulfur cluster binding
CLM_3223	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLM_3227	COG0475	glutathione-regulated potassium exporter activity
CLM_3237	COG0488	(ABC) transporter
CLM_3239	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CLM_3240	COG1309	transcriptional regulator
CLM_3247	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLM_3254	COG1132	(ABC) transporter
CLM_3257	COG1368	sulfuric ester hydrolase activity
CLM_3258	COG0730	response to heat
CLM_3260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLM_3260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLM_3264	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLM_3265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM_3269	COG0151	Belongs to the GarS family
CLM_3270	COG0138	bifunctional purine biosynthesis protein purh
CLM_3271	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLM_3273	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLM_3275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLM_3278	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLM_3279	COG0402	S-adenosylhomocysteine deaminase activity
CLM_3280	COG0493	'glutamate synthase
CLM_3280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLM_3281	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLM_3283	COG2233	PERMEase
CLM_3286	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLM_3288	COG3608	succinylglutamate desuccinylase aspartoacylase
CLM_3288	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLM_3292	COG1120	ATPase activity
CLM_3297	COG2252	PERMEase
CLM_3299	COG1115	amino acid carrier protein
CLM_3300	COG3973	AAA domain
CLM_3303	COG4187	Peptidase family M20/M25/M40
CLM_3304	COG1956	GAF domain-containing protein
CLM_3305	COG1253	flavin adenine dinucleotide binding
CLM_3307	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLM_3308	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLM_3315	COG1725	Transcriptional regulator
CLM_3318	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLM_3319	COG3773	Cell wall hydrolase
CLM_3323	COG0584	glycerophosphoryl diester phosphodiesterase
CLM_3326	COG1253	flavin adenine dinucleotide binding
CLM_3329	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLM_3332	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLM_3333	COG0358	DNA primase activity
CLM_3336	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLM_3336	COG0574	Belongs to the PEP-utilizing enzyme family
CLM_3337	COG0517	IMP dehydrogenase activity
CLM_3338	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLM_3340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLM_3343	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLM_3344	COG1480	7TM receptor with intracellular HD hydrolase
CLM_3347	COG1610	YqeY-like protein
CLM_3349	COG0537	adenosine 5'-monophosphoramidase activity
CLM_3350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLM_3351	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLM_3353	COG0484	heat shock protein binding
CLM_3357	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLM_3358	COG0481	GTPase activity
CLM_3371	COG1921	L-seryl-tRNASec selenium transferase activity
CLM_3372	COG0709	Synthesizes selenophosphate from selenide and ATP
CLM_3374	COG1686	Belongs to the peptidase S11 family
CLM_3375	COG0564	pseudouridine synthase activity
CLM_3376	COG0251	oxidation-reduction process
CLM_3377	COG1316	TRANSCRIPTIONal
CLM_3378	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLM_3379	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLM_3380	COG1534	Rna-binding protein
CLM_3384	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLM_3386	COG1530	ribonuclease E activity
CLM_3390	COG0739	heme binding
CLM_3391	COG0772	Belongs to the SEDS family
CLM_3393	COG2894	cell division
CLM_3394	COG0850	regulation of cytokinetic process
CLM_3398	COG1077	Cell shape determining protein MreB Mrl
CLM_3400	COG0424	maF-like protein
CLM_3410	COG0237	dephospho-CoA kinase activity
CLM_3411	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLM_3411	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLM_3444	COG1484	DNA-dependent DNA replication
CLM_3459	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLM_3460	COG0124	histidyl-tRNA synthetase
CLM_3461	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLM_3462	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLM_3463	COG1490	D-aminoacyl-tRNA deacylase activity
CLM_3464	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLM_3467	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLM_3468	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLM_3472	COG1862	Preprotein translocase
CLM_3476	COG0632	four-way junction helicase activity
CLM_3478	COG0217	transcriptional regulatory protein
CLM_3479	COG1739	Uncharacterized protein family UPF0029
CLM_3481	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLM_3484	COG1773	rubredoxin
CLM_3485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLM_3490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM_3498	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLM_3501	COG0728	peptidoglycan biosynthetic process
CLM_3503	COG0438	transferase activity, transferring glycosyl groups
CLM_3507	COG0438	transferase activity, transferring glycosyl groups
CLM_3515	COG1086	Polysaccharide biosynthesis protein
CLM_3518	COG4193	domain, Protein
CLM_3519	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLM_3521	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLM_3522	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLM_3523	COG1982	Orn Lys Arg decarboxylase major
CLM_3525	COG0280	phosphate acetyltransferase
CLM_3527	COG1683	Conserved Protein
CLM_3528	COG1193	negative regulation of DNA recombination
CLM_3529	COG0826	peptidase U32
CLM_3535	COG0457	Tetratricopeptide repeat
CLM_3535	COG0463	Glycosyl transferase, family 2
CLM_3539	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLM_3540	COG0569	domain protein
CLM_3541	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CLM_3546	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLM_3550	COG1131	(ABC) transporter
CLM_3556	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLM_3557	COG2226	methyltransferase
CLM_3559	COG4608	Belongs to the ABC transporter superfamily
CLM_3560	COG0444	Belongs to the ABC transporter superfamily
CLM_3561	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLM_3562	COG0601	transmembrane transport
CLM_3564	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLM_3566	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLM_3567	COG0436	Aminotransferase
CLM_3571	COG0726	polysaccharide deacetylase
CLM_3577	COG0456	acetyltransferase
CLM_3578	COG1136	(ABC) transporter
CLM_3580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLM_3582	COG1116	anion transmembrane transporter activity
CLM_3583	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLM_3587	COG0612	Peptidase, M16
CLM_3593	COG3123	guanosine phosphorylase activity
CLM_3594	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLM_3597	COG1396	sequence-specific DNA binding
CLM_3601	COG0714	Associated with various cellular activities
CLM_3607	COG1924	4 iron, 4 sulfur cluster binding
CLM_3609	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLM_3610	COG2086	electron transfer activity
CLM_3611	COG1960	acyl-CoA dehydrogenase activity
CLM_3612	COG0183	Belongs to the thiolase family
CLM_3613	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLM_3614	COG1024	Enoyl-CoA hydratase
CLM_3617	COG2252	PERMEase
CLM_3623	COG0584	glycerophosphoryl diester phosphodiesterase
CLM_3624	COG0840	transmembrane signaling receptor activity
CLM_3625	COG1592	Rubrerythrin
CLM_3625	COG1773	rubredoxin
CLM_3631	COG0735	belongs to the Fur family
CLM_3634	COG2378	regulation of single-species biofilm formation
CLM_3639	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLM_3640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLM_3641	COG1067	ATP-dependent peptidase activity
CLM_3641	COG0470	DNA polymerase III
CLM_3644	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLM_3645	COG1082	Xylose isomerase domain protein TIM barrel
CLM_3647	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLM_3648	COG0167	dihydroorotate dehydrogenase activity
CLM_3649	COG0543	2 iron, 2 sulfur cluster binding
CLM_3650	COG0284	orotidine-5'-phosphate decarboxylase activity
CLM_3655	COG1924	4 iron, 4 sulfur cluster binding
CLM_3657	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLM_3658	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLM_3662	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLM_3695	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLM_3698	COG0747	negative chemotaxis
CLM_3699	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLM_3700	COG0154	amidase activity
CLM_3704	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLM_3705	COG0210	DNA helicase
CLM_3706	COG4496	protein, YerC YecD
CLM_3707	COG1187	pseudouridine synthase activity
CLM_3708	COG0741	lytic transglycosylase activity
CLM_3711	COG1671	Belongs to the UPF0178 family
CLM_3714	COG1309	transcriptional regulator
CLM_3716	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLM_3719	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLM_3720	COG2086	electron transfer activity
CLM_3721	COG1960	acyl-CoA dehydrogenase activity
CLM_3726	COG0318	PFAM AMP-dependent synthetase and ligase
CLM_3727	COG1114	Component of the transport system for branched-chain amino acids
CLM_3728	COG0519	Catalyzes the synthesis of GMP from XMP
CLM_3728	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CLM_3729	COG0516	GMP reductase activity
CLM_3729	COG0517	IMP dehydrogenase activity
CLM_3734	COG0398	Pfam SNARE associated Golgi protein
CLM_3741	COG0488	(ABC) transporter
CLM_3742	COG3279	Response regulator of the LytR AlgR family
CLM_3743	COG3275	phosphorelay sensor kinase activity
CLM_3744	COG1966	Carbon starvation protein
CLM_3746	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLM_3747	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLM_3750	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLM_3755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLM_3756	COG0802	atpase or kinase
CLM_3757	COG1214	PFAM Peptidase M22, glycoprotease
CLM_3758	COG0456	acetyltransferase
CLM_3759	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLM_3765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLM_3766	COG0561	phosphatase activity
CLM_3769	COG2033	superoxide reductase activity
CLM_3773	COG1131	(ABC) transporter
CLM_3778	COG1132	(ABC) transporter
CLM_3779	COG3459	Glycosyltransferase 36 associated
CLM_3783	COG1362	aminopeptidase activity
CLM_3784	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLM_3786	COG3973	AAA domain
CLM_3787	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLM_3788	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLM_3789	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLM_3790	COG2827	Endonuclease containing a URI domain
CLM_3792	COG1131	(ABC) transporter
CLM_3794	COG1595	DNA-templated transcription, initiation
CLM_3795	COG0659	secondary active sulfate transmembrane transporter activity
CLM_3799	COG1131	(ABC) transporter
CLM_3803	COG2971	BadF BadG BcrA BcrD
CLM_3804	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLM_3806	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLM_3806	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLM_3807	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLM_3808	COG1486	melibiose metabolic process
CLM_3809	COG2203	Gaf domain
CLM_3809	COG4251	negative regulation of phosphorylation
CLM_3809	COG5001	Diguanylate cyclase
CLM_3809	COG3706	GGDEF domain
CLM_3810	COG4974	Belongs to the 'phage' integrase family
CLM_3814	COG5566	PFAM Mor transcription activator
CLM_3817	COG0656	L-ascorbic acid biosynthetic process
CLM_3819	COG0789	Transcriptional regulator
CLM_3820	COG0295	cytidine deaminase activity
CLM_3822	COG2207	Transcriptional regulator
CLM_3822	COG3708	Transcriptional regulator
CLM_3823	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CLM_3827	COG1959	2 iron, 2 sulfur cluster binding
CLM_3828	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CLM_3834	COG0469	pyruvate kinase activity
CLM_3838	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLM_3840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLM_3842	COG0322	excinuclease ABC activity
CLM_3843	COG1988	membrane-bound metal-dependent
CLM_3845	COG0768	penicillin binding
CLM_3847	COG1716	ATPase activity
CLM_3849	COG0556	nucleotide-excision repair
CLM_3850	COG0750	zinc metalloprotease
CLM_3851	COG3409	Peptidoglycan-binding domain 1 protein
CLM_3851	COG0793	Belongs to the peptidase S41A family
CLM_3852	COG2177	Part of the ABC transporter FtsEX involved in
CLM_3853	COG2884	Cell division ATP-binding protein ftsE
CLM_3854	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLM_3856	COG3958	Transketolase
CLM_3857	COG3959	Transketolase, thiamine diphosphate binding domain
CLM_3859	COG0864	Transcriptional regulator
CLM_3860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLM_3862	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLM_3862	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLM_3863	COG0736	holo-[acyl-carrier-protein] synthase activity
CLM_3867	COG1295	ribonuclease BN
CLM_3872	COG4978	Transcriptional regulator
CLM_3872	COG0789	Transcriptional regulator
CLM_3874	COG2032	superoxide dismutase activity
CLM_3875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLM_3877	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CLM_3878	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLM_3879	COG1028	Short-chain dehydrogenase reductase Sdr
CLM_3881	COG3732	PTS system glucitol sorbitol-specific
CLM_3884	COG1063	alcohol dehydrogenase
CLM_3886	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLM_3889	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLM_3889	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLM_3893	COG0280	phosphate acetyltransferase
CLM_3894	COG3426	butyrate kinase activity
CLM_3895	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLM_3897	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLM_3899	COG3773	Cell wall hydrolase
CLM_3900	COG0492	ferredoxin-NADP+ reductase activity
CLM_3901	COG3118	belongs to the thioredoxin family
CLM_3902	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLM_3905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLM_3906	COG3290	protein histidine kinase activity
CLM_3906	COG3829	transcription factor binding
CLM_3909	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CLM_3909	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CLM_3910	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLM_3911	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLM_3914	COG0101	tRNA pseudouridine synthase activity
CLM_3915	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLM_3917	COG1122	ATPase activity
CLM_3921	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLM_3923	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLM_3948	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLM_3951	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLM_3954	COG1358	cellular component organization or biogenesis
CLM_3956	COG0085	RNA polymerase activity
CLM_3961	COG0250	Participates in transcription elongation, termination and antitermination
CLM_3969	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLM_3972	COG0215	cysteine-tRNA ligase activity
CLM_3973	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLM_3975	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLM_3976	COG4956	integral membrane protein (PIN domain superfamily)
CLM_3978	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CLM_3979	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLM_3980	COG0542	response to heat
CLM_3982	COG3880	PFAM UvrB UvrC protein
CLM_3985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLM_4002	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLM_4003	COG0423	glycine-tRNA ligase activity
CLM_4005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLM_4007	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLM_4009	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CLM_4010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLM_4013	COG2208	phosphoserine phosphatase activity
CLM_4021	COG1098	S1 RNA binding domain
CLM_4025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLM_4027	COG3956	TIGRFAM MazG family protein
CLM_4028	COG2244	polysaccharide biosynthetic process
CLM_4029	COG2002	toxin-antitoxin pair type II binding
CLM_4030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLM_4031	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLM_4032	COG0193	aminoacyl-tRNA hydrolase activity
CLM_4033	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLM_4034	COG5002	protein histidine kinase activity
CLM_4035	COG0745	RESPONSE REGULATOR receiver
CLM_4037	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLM_4039	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLM_4040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLM_4044	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLM_4046	COG2045	Belongs to the ComB family
CLM_4047	COG1242	4 iron, 4 sulfur cluster binding
CLM_4049	COG3949	Membrane
CLM_4051	COG0840	transmembrane signaling receptor activity
CLM_4054	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLM_4055	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLM_4056	COG0174	glutamine synthetase
CLM_4059	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLM_4061	COG0653	protein targeting
CLM_4062	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLM_4065	COG2814	Major facilitator Superfamily
CLM_4067	COG1309	transcriptional regulator
CLM_4069	COG0024	Methionine aminopeptidase
CLM_4070	COG0778	Nitroreductase
CLM_4071	COG1328	CTP reductase activity
CLM_4072	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLM_4074	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLM_4076	COG1160	GTP binding
CLM_4078	COG0438	transferase activity, transferring glycosyl groups
CLM_4079	COG0613	PHP domain protein
CLM_4082	COG0583	DNA-binding transcription factor activity
CLM_4083	COG1404	Belongs to the peptidase S8 family
CLM_4084	COG0583	DNA-binding transcription factor activity
CLM_4086	COG0825	malonyl-CoA metabolic process
CLM_4087	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLM_4088	COG0439	Biotin carboxylase
CLM_4090	COG0511	ligase activity, forming carbon-carbon bonds
CLM_4091	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLM_4092	COG1028	Short-chain dehydrogenase reductase Sdr
CLM_4093	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLM_4095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLM_4096	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLM_4099	COG0739	heme binding
CLM_4118	COG2081	HI0933 family
CLM_4121	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLM_4124	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLM_4125	COG0305	Participates in initiation and elongation during chromosome replication
CLM_4126	COG0470	DNA polymerase III
CLM_4126	COG1067	ATP-dependent peptidase activity
CLM_4128	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLM_4133	COG0360	Binds together with S18 to 16S ribosomal RNA
CLM_4134	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLM_4136	COG0668	transmembrane transport
CLM_4139	COG0628	permease
CLM_4143	COG1475	DNA binding
CLM_4144	COG1192	Involved in chromosome partitioning
CLM_4145	COG1475	DNA binding
CLM_4146	COG0357	Ribosomal RNA small subunit methyltransferase G
CLM_4149	COG1847	R3H domain protein
CLM_4151	COG0759	Could be involved in insertion of integral membrane proteins into the membrane