locus-tag class description NPD12_100 ENOG4108IUQ atp-dependent protease NPD12_1001 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_1003 ENOG4105CE1 Ferrous iron transport protein b NPD12_1004 ENOG4105CE1 Ferrous iron transport protein b NPD12_1005 ENOG4105CVJ phosphoglycerate mutase NPD12_1006 ENOG41073R8 VanW family NPD12_1013 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase NPD12_1014 ENOG4105EEI dihydropteroate synthase NPD12_1016 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase NPD12_1017 ENOG4107Y70 Heat shock protein NPD12_1018 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NPD12_1019 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase NPD12_102 ENOG4105BZR domain protein NPD12_1022 ENOG4105JVQ RNA Polymerase NPD12_1027 ENOG4105CJ1 ABC, transporter NPD12_1028 ENOG41067QW Transcriptional regulator NPD12_1031 ENOG4107S9D Alpha beta hydrolase NPD12_1036 ENOG4105RHY Pfam:UPF0157 NPD12_1040 ENOG4105KVH Transcriptional regulator NPD12_1041 ENOG4108TVJ Nitroreductase NPD12_1043 ENOG4105F0F Oxalate decarboxylase NPD12_1044 ENOG4108URH decarboxylase NPD12_1047 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) NPD12_1049 ENOG4105D29 Helix-turn-helix type 11 domain protein NPD12_1053 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) NPD12_1054 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NPD12_1055 ENOG4105HFT AraC family transcriptional regulator NPD12_1056 ENOG4108TVJ Nitroreductase NPD12_1058 ENOG4107Z6X Transcriptional regulator NPD12_106 ENOG4108UUM single-stranded DNA-binding protein NPD12_1060 ENOG4105CID antiterminator NPD12_1061 ENOG4105C5Y PTS System NPD12_1062 ENOG4105CS2 ec 3.2.1.21 NPD12_1064 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) NPD12_1077 ENOG4105T2N Domain of unknown function (DUF2382) NPD12_1078 ENOG4108MTT Glutamate-rich protein grpB NPD12_1079 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein NPD12_108 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase NPD12_1086 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NPD12_1088 ENOG4105BZU Histidine kinase NPD12_1089 ENOG4105CM2 brancheD-chain amino acid aminotransferase NPD12_1090 ENOG4107ZYJ bioY protein NPD12_1094 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) NPD12_1097 ENOG4107TXC Transcriptional regulator NPD12_1099 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) NPD12_11 ENOG4105C0H protease NPD12_110 ENOG4105D8X mechanosensitive ion channel NPD12_1100 ENOG4105CIH Imidazole acetol-phosphate transaminase NPD12_1101 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) NPD12_1108 ENOG4105D52 delta-aminolevulinic acid dehydratase NPD12_1109 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) NPD12_1110 ENOG41081F0 Precorrin-8x methylmutase NPD12_1115 ENOG4105VEV -acetyltransferase NPD12_1118 ENOG4107Y03 Nitroreductase NPD12_112 ENOG4105C9B Cysteine desulfurase NPD12_1125 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase NPD12_113 ENOG4108REF Sporulation integral membrane protein ytvi NPD12_1132 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) NPD12_1133 ENOG4105CIA precorrin-4 C(11)-methyltransferase NPD12_1134 ENOG4108P62 biosynthesis protein (CbiG) NPD12_1135 ENOG4105E4R Precorrin-3B C17-methyltransferase NPD12_1136 ENOG4108JTQ reductase NPD12_1138 ENOG4107PPM cobalt chelatase NPD12_1139 ENOG4105JZC GHMP kinase NPD12_114 ENOG4108ZDA Sporulation protein YyaC NPD12_1140 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase NPD12_1142 ENOG4107V9H nitrite transporter NPD12_1143 ENOG4105D5B Sulfite reductase, subunit A NPD12_1144 ENOG4107SHJ sulfite reductase subunit b NPD12_1145 ENOG410810Y Sulfite reductase NPD12_1151 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NPD12_1153 ENOG4105E0A ABC, transporter NPD12_1154 ENOG4105EHG Permease protein NPD12_1155 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) NPD12_1156 ENOG4105PAD Hydrolase NPD12_1160 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) NPD12_1164 ENOG4105CMT Dihydroxyacetone kinase NPD12_1166 ENOG4105FTV AraC Family Transcriptional Regulator NPD12_1167 ENOG4108HYG acetyltransferase NPD12_117 ENOG4105FA0 parb-like partition protein NPD12_1177 ENOG4105BZU Histidine kinase NPD12_1179 ENOG4108UZE carboxy-peptidase NPD12_118 ENOG4107QJE Chromosome Partitioning Protein NPD12_1185 ENOG4105C9U ATP-dependent DNA helicase RecQ NPD12_1186 ENOG4105KY8 Rubrerythrin NPD12_1187 ENOG4108RE9 Phosphodiesterase NPD12_1188 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_119 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) NPD12_1192 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) NPD12_1196 ENOG4105QUH Domain of unknown function (DUF2088) NPD12_1197 ENOG4105BZJ Electron transfer flavoprotein NPD12_1198 ENOG4105C10 Electron transfer flavoprotein NPD12_1199 ENOG4105CQB FAD linked oxidase domain protein NPD12_12 ENOG4105BZU Histidine kinase NPD12_1204 ENOG4105CHM Aminotransferase NPD12_1206 ENOG4108INS Transcriptional regulator NPD12_1207 ENOG4108Z5V transcriptional regulator, merr family NPD12_1209 ENOG4105C5S asparaginyl-tRNA synthetase NPD12_1215 ENOG4105PAD Hydrolase NPD12_1218 ENOG4107V2S Transcriptional regulator NPD12_1219 ENOG4105EPI acetyltransferase, (GNAT) family NPD12_1221 ENOG4105CE1 Ferrous iron transport protein b NPD12_1225 ENOG4108VXD carboxy-peptidase NPD12_1228 ENOG4105BZU Histidine kinase NPD12_1230 ENOG4107E6A Cytochrome p-450 NPD12_1233 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_1234 ENOG4105BZU Histidine kinase NPD12_1236 ENOG4105E7U AraC family transcriptional regulator NPD12_1237 ENOG4105DHS permease protein NPD12_1238 ENOG4105CM4 permease protein NPD12_1239 ENOG4108IPW abc transporter atp-binding protein NPD12_124 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins NPD12_1242 ENOG4105BZ1 (ABC) transporter NPD12_1243 ENOG4105BZ1 (ABC) transporter NPD12_1245 ENOG4105DY9 regulatoR NPD12_1251 ENOG4105C7Z Conserved Protein NPD12_1252 ENOG4108QEG Membrane NPD12_1258 ENOG4105C5H ABC transporter NPD12_1265 ENOG4105CXY transporter NPD12_1268 ENOG4105CIH Imidazole acetol-phosphate transaminase NPD12_1269 ENOG4105CJW magnesium transporter NPD12_1271 ENOG4105CE1 Ferrous iron transport protein b NPD12_1275 ENOG4108NNZ chitinase NPD12_1278 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) NPD12_1279 ENOG4108UMI ABC transporter, permease NPD12_1280 ENOG4105D01 (LipO)protein NPD12_1282 ENOG4105D01 (LipO)protein NPD12_1285 ENOG4105JXH GntR family transcriptional regulator NPD12_129 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) NPD12_1290 ENOG4105CY0 Metallo-Beta-Lactamase NPD12_1292 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate NPD12_1293 ENOG4105C26 Dehydrogenase NPD12_1296 ENOG4108U05 Transcriptional regulator NPD12_1297 ENOG4105C3S Mate efflux family protein NPD12_13 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_1300 ENOG4105VNH ABC transporter solute-binding protein NPD12_1302 ENOG4105F38 ABC transporter, permease NPD12_1303 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NPD12_1308 ENOG4105DWU Membrane NPD12_1309 ENOG4108UW5 maltose o-acetyltransferase NPD12_1313 ENOG4105BZU Histidine kinase NPD12_1317 ENOG4105CJW magnesium transporter NPD12_1319 ENOG4108JQ1 Dehydrogenase NPD12_1321 ENOG4105CNW domain protein NPD12_1323 ENOG4105C94 Transporter NPD12_1326 ENOG4108RWI nicotinamidase NPD12_1327 ENOG4105C72 UPF0176 protein NPD12_133 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NPD12_1333 ENOG4107RM6 sulfurtransferase NPD12_1335 ENOG4105C02 permease NPD12_134 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NPD12_1342 ENOG4107RCV ABC transporter, permease NPD12_1343 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NPD12_1346 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) NPD12_1347 ENOG41082UD thioesterase Superfamily protein NPD12_1350 ENOG4105C7J ABC transporter, permease NPD12_1351 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) NPD12_1353 ENOG4105CEB Aspartate aminotransferase NPD12_1354 ENOG4108IPJ Membrane NPD12_1355 ENOG4105DD7 kinase (PfkB family NPD12_1357 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) NPD12_1358 ENOG410908R Methenyltetrahydrofolate cyclohydrolase NPD12_1360 ENOG4105DQF Hydrolase NPD12_1366 ENOG4105C6T cysteine synthase NPD12_1367 ENOG4105E5Q amino acid AbC transporter NPD12_1368 ENOG4105EAB amino acid AbC transporter NPD12_1374 ENOG4108WCX response regulator NPD12_1378 ENOG4108QXE glycerophosphoryl diester phosphodiesterase NPD12_1387 ENOG4105DKQ ROK family NPD12_1390 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) NPD12_1392 ENOG4105DVE abc transporter atp-binding protein NPD12_1398 ENOG4105BZU Histidine kinase NPD12_14 ENOG4105C5T Phosphoribosyl pyrophosphate synthase NPD12_1400 ENOG4105EJQ L-serine dehydratase NPD12_1403 ENOG4108U5J '-nucleotidase NPD12_1404 ENOG4105C42 Type I secretion membrane fusion protein (HlyD NPD12_1408 ENOG4108IGT Dipeptidase NPD12_141 ENOG4108Z3G 3H domain protein NPD12_1410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NPD12_1412 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NPD12_1413 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NPD12_1418 ENOG4105WEF catalase NPD12_1419 ENOG4108HQ0 Exopolysaccharide biosynthesis protein NPD12_1423 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) NPD12_1430 ENOG4108IG5 Transcriptional regulator NPD12_1438 ENOG41067QW Transcriptional regulator NPD12_1442 ENOG4105C26 Dehydrogenase NPD12_1445 ENOG4105EZ5 reductase NPD12_1446 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family NPD12_1447 ENOG4105CYT Selenoprotein B, glycine betaine sarcosine D-proline reductase family NPD12_1457 ENOG4108KU3 Integrase NPD12_1477 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain NPD12_1478 ENOG4106GRJ chromatin binding NPD12_1484 ENOG41061CV Terminase small subunit NPD12_1497 ENOG4105PQS phage protein NPD12_1498 ENOG4105FR7 XkdM protein, phage-like element PBSX NPD12_1506 ENOG41066EA baseplate J family protein NPD12_1518 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) NPD12_1520 ENOG4105FB2 class II Aldolase NPD12_1521 ENOG4105E98 transcriptional regulator DeoR family NPD12_1524 ENOG4108QY0 Membrane NPD12_1534 ENOG4105C7W Xanthine dehydrogenase NPD12_1535 ENOG4108HR6 Dehydrogenase NPD12_1536 ENOG4108UTP (2Fe-2S)-binding domain protein NPD12_1537 ENOG4107Y2X deaminase NPD12_1538 ENOG4105C9U ATP-dependent DNA helicase RecQ NPD12_1542 ENOG4105CN5 Metallo-Beta-Lactamase NPD12_1543 ENOG4105BZG amino acid carrier protein NPD12_1545 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) NPD12_1546 ENOG4107R8N Glycosyl transferase, family 2 NPD12_155 ENOG4108RDQ ABC transporter NPD12_1552 ENOG4105C59 p-type ATPase NPD12_1554 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic NPD12_1555 ENOG4105BZ1 (ABC) transporter NPD12_1559 ENOG4105BZU Histidine kinase NPD12_1580 ENOG4105C1A potassium transporter peripheral membrane NPD12_1581 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) NPD12_1582 ENOG4105C4R Atp-dependent dna helicase NPD12_1582 ENOG4105C4R Atp-dependent dna helicase NPD12_1584 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NPD12_1585 ENOG4105F0V Cell wall hydrolase NPD12_1587 ENOG4105JFG SpoIID LytB domain protein NPD12_1589 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) NPD12_1592 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit NPD12_1594 ENOG4107SJS nitrite reductase, (NAD(P)H) NPD12_1595 ENOG4105EFQ Two component transcriptional regulator (Winged helix family NPD12_1597 ENOG4107WD8 ABC transporter, permease NPD12_1600 ENOG4105BZ1 (ABC) transporter NPD12_1601 ENOG4105BZ1 (ABC) transporter NPD12_1602 ENOG4105VXR cytoplasmic protein NPD12_1603 ENOG4108W3Y Transcriptional regulator, Crp Fnr family NPD12_1606 ENOG4105EHG Permease protein NPD12_1607 ENOG4105E0A ABC, transporter NPD12_1609 ENOG4105WCA Ferredoxin NPD12_1610 ENOG4106KNT transcriptional regulator NPD12_1620 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_1623 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NPD12_1624 ENOG4108RZA ABC transporter NPD12_1625 ENOG4108JQ7 (ABC) transporter NPD12_1627 ENOG4105FAV ABC, transporter NPD12_1628 ENOG4105FDK ABC transporter NPD12_1629 ENOG4105DSE periplasmic solute binding protein NPD12_1632 ENOG4105BZU Histidine kinase NPD12_1635 ENOG4105D7T ABC transporter NPD12_1636 ENOG4105G5W regulator Fur family NPD12_1639 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) NPD12_164 ENOG4105C28 cystathionine NPD12_1640 ENOG4107R7I amino acid NPD12_1641 ENOG4105KWG Pfam:DUF1696 NPD12_1642 ENOG4105BZU Histidine kinase NPD12_1643 ENOG4105WH1 Two component transcriptional regulator luxr family NPD12_1644 ENOG4105CJ1 ABC, transporter NPD12_165 ENOG4108Z6B deaminase NPD12_1650 ENOG4105VEQ Cold shock protein NPD12_1651 ENOG4105CIN aminoacyl-histidine dipeptidase NPD12_1654 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) NPD12_1664 ENOG4105C87 Aminotransferase class I and II NPD12_1665 ENOG4105EAB amino acid AbC transporter NPD12_1666 ENOG4105E5Q amino acid AbC transporter NPD12_1669 ENOG4105DZ1 carboxypeptidase NPD12_167 ENOG4105C6E dna polymerase iii NPD12_1670 ENOG4105M6F mutator MutT protein NPD12_1672 ENOG4107QW4 alcohol dehydrogenase NPD12_1674 ENOG4105CSX c4-dicarboxylate anaerobic carrier NPD12_1675 ENOG4105DAP Nicotinate phosphoribosyltransferase NPD12_1676 ENOG4105CT1 (ABC) transporter NPD12_1677 ENOG4105E5Q amino acid AbC transporter NPD12_1681 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) NPD12_1682 ENOG4105CH2 amidohydrolase NPD12_1683 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase NPD12_1684 ENOG4105C34 Pseudouridine synthase NPD12_1690 ENOG4105DAN ATP-dependent protease NPD12_1691 ENOG4105D4Y metalloprotease NPD12_1697 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase NPD12_17 ENOG4105DFT pur operon repressor NPD12_1701 ENOG4108UT2 hemolysin iii NPD12_1702 ENOG4105C3G gtp-binding protein NPD12_1703 ENOG4108V6E Cell division protein mraZ NPD12_1706 ENOG4105CJN penicillin-binding protein NPD12_1708 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) NPD12_1710 ENOG4105CNI cell division protein FtsW NPD12_1713 ENOG4105K67 small basic protein NPD12_1715 ENOG4105DFA alanine racemase domain protein NPD12_1717 ENOG4108VIA integral membrane protein NPD12_1719 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) NPD12_1720 ENOG4105D49 3-dehydroquinate synthase NPD12_1721 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) NPD12_1722 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase NPD12_1723 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase NPD12_1725 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) NPD12_1726 ENOG4105C34 Pseudouridine synthase NPD12_1727 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) NPD12_1729 ENOG4105CGK Exodeoxyribonuclease III NPD12_173 ENOG4105E09 nadh pyrophosphatase NPD12_1730 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) NPD12_1732 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein NPD12_1733 ENOG4105E0C molybdate abc transporter NPD12_1734 ENOG4108IJ6 ABC transporter NPD12_1738 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) NPD12_1739 ENOG4105DFD Na H antiporter NPD12_1741 ENOG4105CKI cobalamin synthesis protein NPD12_1743 ENOG4108Q52 Methyltransferase cognate corrinoid protein NPD12_1744 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) NPD12_1745 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) NPD12_1746 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) NPD12_1747 ENOG4108UMI ABC transporter, permease NPD12_1748 ENOG4105D01 (LipO)protein NPD12_1750 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase NPD12_1751 ENOG4105CU9 asparagine synthetase A NPD12_1753 ENOG4105C9U ATP-dependent DNA helicase RecQ NPD12_1754 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) NPD12_1755 ENOG4105CPC Aldo Keto reductase NPD12_1756 ENOG4108ZQX ybak prolyl-trna synthetase NPD12_1758 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NPD12_1760 ENOG4105DRS transport system, permease NPD12_1763 ENOG4105JXH GntR family transcriptional regulator NPD12_1766 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase NPD12_1768 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_177 ENOG4105CUZ uba thif-type nad fad binding protein NPD12_1771 ENOG4105KVH Transcriptional regulator NPD12_1773 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) NPD12_1775 ENOG4105EQN UPF0261 protein NPD12_1783 ENOG4108HU6 Metal dependent phosphohydrolase NPD12_1784 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic NPD12_1789 ENOG4105WH1 Two component transcriptional regulator luxr family NPD12_179 ENOG4105D9U N-acetyltransferase NPD12_1791 ENOG4105D29 Helix-turn-helix type 11 domain protein NPD12_1793 ENOG4105CIZ coA-substrate-specific enzyme activase NPD12_1794 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase NPD12_1795 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) NPD12_1802 ENOG4107RHR regulatoR NPD12_1804 ENOG4108RVA ribokinase NPD12_1807 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) NPD12_1809 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) NPD12_1815 ENOG4105CUC YeeE YedE family protein NPD12_1817 ENOG41066VF YeeE YedE family protein NPD12_1818 ENOG4105DUM transcriptional regulator, lysR family NPD12_1820 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase NPD12_1821 ENOG4105CUC YeeE YedE family protein NPD12_1822 ENOG4105DA5 (ABC) transporter NPD12_1827 ENOG4105CEU Arginine dihydrolase NPD12_1829 ENOG4108UT2 hemolysin iii NPD12_1832 ENOG4105EKQ RNA-directed DNA polymerase NPD12_1840 ENOG410874W AraC family transcriptional regulator NPD12_1841 ENOG4105BZ1 (ABC) transporter NPD12_1842 ENOG4105BZ1 (ABC) transporter NPD12_1843 ENOG4105FKQ transcriptional regulator NPD12_1844 ENOG4105E2R ROK family NPD12_1846 ENOG4105CI1 PTS System NPD12_1849 ENOG4105EGD dinuclear metal center protein, YbgI family NPD12_1855 ENOG410667J hydrolase NPD12_1856 ENOG4105E98 transcriptional regulator DeoR family NPD12_1861 ENOG4105SYT Methylenetetrahydrofolate reductase NPD12_1863 ENOG4105C3R Methionine synthase NPD12_1869 ENOG4107RUY (E1 component), alpha subunit NPD12_1871 ENOG4106Z86 ATP-nad acox kinase NPD12_1872 ENOG4105C7S Dehydrogenase NPD12_1874 ENOG4105DF9 Lipoate-protein, ligase NPD12_1875 ENOG4108IJ8 ABC transporter NPD12_1877 ENOG4107QID Threonine synthase NPD12_1879 ENOG4105CFH Aspartokinase NPD12_1880 ENOG4105D6E homoserine dehydrogenase NPD12_1883 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein NPD12_1884 ENOG4105BZ8 glutamate synthase NPD12_1887 ENOG4108J53 cell adhesion domain-containing protein NPD12_1899 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) NPD12_1900 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer NPD12_1904 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_1908 ENOG4108R96 Methyltransferase, YaeB family NPD12_1910 ENOG4108J59 Extracellular solute-binding protein, family 5 NPD12_1911 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component NPD12_1912 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NPD12_1914 ENOG4105DVT helicase NPD12_1915 ENOG4105PTM secreted protein NPD12_1917 ENOG4105DE4 1-phosphofructokinase NPD12_1918 ENOG4105DUX Transporter NPD12_1923 ENOG4105DD7 kinase (PfkB family NPD12_1924 ENOG4105K4I Scp-like extracellular NPD12_1926 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer NPD12_1927 ENOG4105C5H ABC transporter NPD12_1928 ENOG410810Y Sulfite reductase NPD12_1929 ENOG4107R88 Chemotaxis protein (CheV) NPD12_1931 ENOG4105QNR S1 RNA binding domain protein NPD12_1932 ENOG4105C1J atp-dependent rna helicase NPD12_1935 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj NPD12_1936 ENOG41090A1 ferritin NPD12_1937 ENOG4107YTP response regulator receiver protein NPD12_1939 ENOG4105DWD nucleoside recognition domain protein NPD12_1943 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NPD12_1946 ENOG4105CXI aluminum resistance protein NPD12_1952 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NPD12_1954 ENOG4105CHM Aminotransferase NPD12_1957 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) NPD12_1960 ENOG4105CBX hi0933 family NPD12_1961 ENOG4105D82 Glutamate dehydrogenase NPD12_1962 ENOG4106G6Q Transcriptional regulator NPD12_1963 ENOG4105FE9 pseudouridine synthase NPD12_1968 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_1969 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) NPD12_1977 ENOG4108115 UPF0145 protein NPD12_1979 ENOG4105Y5S NADH ubiquinone oxidoreductase, 24 kD NPD12_1983 ENOG4105C45 hydrogenase expression formation protein (HypE) NPD12_1984 ENOG4105CQS hydrogenase expression formation protein HypD NPD12_1985 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF NPD12_1989 ENOG4105DPX Hydrogenase, large subunit NPD12_1990 ENOG4105E3S small subunit NPD12_1999 ENOG4105C5H ABC transporter NPD12_200 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) NPD12_2000 ENOG4107QHI -hydrogenase NPD12_2001 ENOG4107QIZ NADH dehydrogenase NPD12_2002 ENOG410902H NADH dehydrogenase (Ubiquinone), 24 kDa subunit NPD12_2006 ENOG4105DZ1 carboxypeptidase NPD12_2008 ENOG4105KBJ sporulation protein ytfj NPD12_2010 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) NPD12_2012 ENOG4105DZ1 carboxypeptidase NPD12_2016 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) NPD12_2017 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) NPD12_2018 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NPD12_2022 ENOG4107SC7 Inner membrane transporter yjeM NPD12_2038 ENOG4107QQR Sporulation NPD12_2039 ENOG4105S1Z Stage IV sporulation protein B NPD12_204 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) NPD12_2040 ENOG4105CVG Homoserine O-transsuccinylase NPD12_2041 ENOG4105D6E homoserine dehydrogenase NPD12_2043 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) NPD12_2046 ENOG4105DX0 Hemolysin A NPD12_2058 ENOG4105KQ4 Stage iii sporulation protein ad NPD12_2059 ENOG4108CQH stage III sporulation protein AC NPD12_206 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A NPD12_2061 ENOG4105CD2 stage iii sporulation protein aa NPD12_2073 ENOG4108VAU general secretion pathway protein G NPD12_2074 ENOG4105D7Q type ii secretion system NPD12_2075 ENOG4107QHF type ii secretion system protein e NPD12_2078 ENOG4105F23 Fibronectin-binding protein NPD12_2082 ENOG4105CVK Glutamate decarboxylase NPD12_2084 ENOG4105EC8 Methyl-accepting chemotaxis NPD12_2088 ENOG4105BZU Histidine kinase NPD12_2091 ENOG4105BZU Histidine kinase NPD12_2095 ENOG4105CJ1 ABC, transporter NPD12_2096 ENOG4105BZ1 (ABC) transporter NPD12_2102 ENOG4105WE2 aldehyde ferredoxin oxidoreductase NPD12_2105 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) NPD12_2107 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family NPD12_2108 ENOG4105CVM Molybdenum cofactor synthesis domain protein NPD12_2109 ENOG4108RIR Molybdenum cofactor biosynthesis protein NPD12_211 ENOG4105CXN decarboxylase NPD12_2113 ENOG4105UQX Mate efflux family protein NPD12_2117 ENOG4107WD8 ABC transporter, permease NPD12_2119 ENOG4107S9D Alpha beta hydrolase NPD12_2120 ENOG4105BZ1 (ABC) transporter NPD12_2122 ENOG41090E6 transcriptional regulator MERR family NPD12_213 ENOG4105X0R protein from nitrogen regulatory protein P-II NPD12_2130 ENOG4105BZU Histidine kinase NPD12_2131 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_2133 ENOG4108W7F transporter, permease NPD12_2134 ENOG4108JJB ABC transporter NPD12_2135 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein NPD12_2136 ENOG4106M28 alanine racemase domain protein NPD12_2137 ENOG4108B31 Spore germination protein NPD12_2138 ENOG4105E1K spore germination protein NPD12_214 ENOG4107XK4 dna polymerase iii subunits gamma and tau NPD12_2146 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) NPD12_2148 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) NPD12_2149 ENOG4105C5Y PTS System NPD12_215 ENOG4105MA4 psp1 domain protein NPD12_2150 ENOG4105CG3 alpha amylase, catalytic region NPD12_2151 ENOG4107414 GntR family transcriptional regulator NPD12_2152 ENOG4105DM4 PTS System NPD12_2153 ENOG4105DM4 PTS System NPD12_2154 ENOG4106VEM tagatose-6-phosphate kinase NPD12_2155 ENOG4105D2N Aldolase NPD12_2157 ENOG4105G7B Protein of unknown function (DUF2992) NPD12_2161 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_2162 ENOG4106M28 alanine racemase domain protein NPD12_2164 ENOG4105D9R oxidoreductase NPD12_2165 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) NPD12_2167 ENOG4105BZU Histidine kinase NPD12_2169 ENOG4108JUB Transcriptional regulator NPD12_2170 ENOG4105C1J atp-dependent rna helicase NPD12_2171 ENOG4105K4I Scp-like extracellular NPD12_2173 ENOG4105SX7 Transporter NPD12_2175 ENOG4105CDA abc transporter atp-binding protein NPD12_2176 ENOG4105E5Q amino acid AbC transporter NPD12_2177 ENOG4108HW3 (ABC) transporter NPD12_2178 ENOG4105QUH Domain of unknown function (DUF2088) NPD12_2179 ENOG4105C5R Aminotransferase NPD12_218 ENOG41060K3 Methyltransferase NPD12_2187 ENOG4105DUX Transporter NPD12_2188 ENOG4105DUX Transporter NPD12_2189 ENOG4105DC7 peptidase M24 NPD12_219 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) NPD12_2191 ENOG4105C8J )-transporter NPD12_2198 ENOG4105CCI Myosin-Cross-Reactive Antigen NPD12_22 ENOG4107VXZ Hydrolase NPD12_220 ENOG4107SN7 NLP P60 protein NPD12_2202 ENOG4108N3W hemolysin secretion protein NPD12_2206 ENOG4105D7W serine acetyltransferase NPD12_2209 ENOG4107V9E glucose-1-phosphate thymidylyltransferase NPD12_221 ENOG4105KRN Transcriptional regulator, abrb family NPD12_2216 ENOG4105DZC cytosine deaminase NPD12_2217 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin NPD12_2225 ENOG4105DZR Type I site-specific deoxyribonuclease NPD12_2230 ENOG4105C1B dTDP-glucose 4-6-dehydratase NPD12_2232 ENOG4107S6X Glycosyl transferase, family 2 NPD12_2240 ENOG4105KNY Microcompartments protein NPD12_2241 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) NPD12_2242 ENOG4108EKI Dehydrogenase NPD12_2243 ENOG4105KNY Microcompartments protein NPD12_2244 ENOG4105NDK ethanolamine utilization protein NPD12_2247 ENOG4107RWI ethanolamine utilization protein eutJ NPD12_2249 ENOG4105KTW ethanolamine utilization protein NPD12_225 ENOG4107BJW polysaccharide deacetylase NPD12_2250 ENOG4105M3W utilization protein NPD12_2251 ENOG4105F1A Pyruvate formate-lyase NPD12_2252 ENOG4105C6N Formate acetyltransferase NPD12_2253 ENOG4108EKI Dehydrogenase NPD12_2254 ENOG4105KNY Microcompartments protein NPD12_2255 ENOG4105KNY Microcompartments protein NPD12_2258 ENOG4107TXC Transcriptional regulator NPD12_2261 ENOG4105DJ2 Major Facilitator Superfamily NPD12_2262 ENOG41073TP transcriptional regulator NPD12_2266 ENOG4108XI2 Domain of unknown function (DUF1963) NPD12_227 ENOG4108JIC nucleoside recognition domain protein NPD12_2272 ENOG4105CJZ response regulator NPD12_2275 ENOG4108IUW ABC transporter NPD12_2278 ENOG4105VMP Transcriptional regulator NPD12_2280 ENOG4105CPQ Dehydrogenase NPD12_2284 ENOG4105C19 ABC transporter NPD12_2289 ENOG4106ETB IIa component NPD12_229 ENOG4105UQX Mate efflux family protein NPD12_2290 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) NPD12_2293 ENOG4108UW5 maltose o-acetyltransferase NPD12_2295 ENOG4105DUX Transporter NPD12_2296 ENOG4108D32 Methyltransferase NPD12_2297 ENOG41086D8 Transcriptional regulator NPD12_230 ENOG4108UN4 phage SPO1 DNA polymerase-related protein NPD12_2306 ENOG4108IMY Transcriptional regulator NPD12_2309 ENOG4107R7I amino acid NPD12_2312 ENOG4105CIZ coA-substrate-specific enzyme activase NPD12_2314 ENOG4105C10 Electron transfer flavoprotein NPD12_2315 ENOG4105BZJ Electron transfer flavoprotein NPD12_2316 ENOG4105C1G acyl-Coa dehydrogenase NPD12_2317 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase NPD12_2318 ENOG4105CMH dehydratase NPD12_232 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) NPD12_2323 ENOG4105FKZ Methyl-accepting chemotaxis NPD12_2326 ENOG4107QHE Choloylglycine hydrolase NPD12_2328 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) NPD12_2329 ENOG4105C6Z Gluconate NPD12_233 ENOG4108UH6 UPF0754 membrane protein NPD12_2331 ENOG4105G63 Type III effector Hrp-dependent NPD12_2332 ENOG4105E98 transcriptional regulator DeoR family NPD12_2333 ENOG4105KY5 gCN5-related N-acetyltransferase NPD12_2336 ENOG4108IG5 Transcriptional regulator NPD12_2339 ENOG41090FM Phosphatase NPD12_234 ENOG4105F8V Hydrolase, tatD family NPD12_2341 ENOG4105CJG carbon-monoxide dehydrogenase catalytic subunit NPD12_2343 ENOG4107RSS Hydrogenase accessory protein HypB NPD12_2346 ENOG4105D1F ATP-binding protein NPD12_2349 ENOG4105ER2 Ompa motb domain protein NPD12_235 ENOG41069ER domain protein NPD12_2350 ENOG4105E14 MotA TolQ exbB proton channel NPD12_2351 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase NPD12_2354 ENOG4105EPD Oligopeptide transporter, Opt family NPD12_2355 ENOG4105CIN aminoacyl-histidine dipeptidase NPD12_2357 ENOG4105BZW Glycerate kinase NPD12_2359 ENOG4105E1F short-chain dehydrogenase reductase NPD12_2360 ENOG4108SDH ABC, transporter NPD12_2361 ENOG4108IUW ABC transporter NPD12_2362 ENOG4107YB6 acetyltransferase, (GNAT) family NPD12_2363 ENOG4108U05 Transcriptional regulator NPD12_2368 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A NPD12_2370 ENOG4105E5D amino acid NPD12_2371 ENOG4108UVJ appr-1-p processing domain protein NPD12_2382 ENOG4105VKD bioY protein NPD12_2384 ENOG4105DC7 peptidase M24 NPD12_2385 ENOG4105DUX Transporter NPD12_2400 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NPD12_2401 ENOG4105BZ1 (ABC) transporter NPD12_2402 ENOG4105BZ1 (ABC) transporter NPD12_2408 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NPD12_2412 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) NPD12_2416 ENOG4105EKQ RNA-directed DNA polymerase NPD12_242 ENOG4105C19 ABC transporter NPD12_2429 ENOG4105EKQ RNA-directed DNA polymerase NPD12_243 ENOG4107RBB ABC transporter, permease NPD12_2430 ENOG4105EKQ RNA-directed DNA polymerase NPD12_2431 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate NPD12_2437 ENOG41062D9 Histidine kinase NPD12_2438 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_2442 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) NPD12_2444 ENOG4105WG9 Conserved Protein NPD12_2446 ENOG4105CHM Aminotransferase NPD12_2447 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) NPD12_2449 ENOG4106YN8 Prenyltransferase NPD12_245 ENOG41084T3 4fe-4S ferredoxin iron-sulfur binding domain-containing protein NPD12_2450 ENOG4105MCT stage V sporulation protein S NPD12_2452 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) NPD12_2453 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase NPD12_2455 ENOG4105CNU cell division protein FtsK NPD12_2456 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit NPD12_2459 ENOG4105C1V Peptidase, M16 NPD12_2462 ENOG4105DTN riboflavin biosynthesis protein ribF NPD12_2464 ENOG4105SFS phosphoesterase RecJ domain protein NPD12_2467 ENOG4105VHM ribosomal protein NPD12_2468 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination NPD12_2469 ENOG4105CHV Transcription elongation factor NusA NPD12_247 ENOG4105BZU Histidine kinase NPD12_2471 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) NPD12_2472 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) NPD12_2473 ENOG4105DZP Membrane-associated zinc metalloprotease NPD12_2478 ENOG4105KNE Phosphatidate cytidylyltransferase NPD12_2479 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) NPD12_248 ENOG4105KT7 mgtC SapB transporter NPD12_2485 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) NPD12_2486 ENOG4105C79 DNA protecting protein DprA NPD12_2487 ENOG4105C0P Mg chelatase subunit ChlI NPD12_249 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase NPD12_2490 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) NPD12_2495 ENOG4105VB6 UPF0109 protein NPD12_2499 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) NPD12_25 ENOG4105N5T Radical SAM Protein NPD12_2503 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) NPD12_2504 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) NPD12_2506 ENOG41067VY 50S ribosomal protein L32 NPD12_2507 ENOG4105KNH Nucleic acid-binding protein NPD12_2509 ENOG4108IJ2 phosphate acetyltransferase NPD12_2511 ENOG4107T4V d-proline reductase NPD12_2512 ENOG4107T4V d-proline reductase NPD12_2514 ENOG41088D5 d-proline reductase NPD12_2517 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_2520 ENOG4105E5D amino acid NPD12_2522 ENOG4105CTU Proline racemase NPD12_2524 ENOG41088D5 d-proline reductase NPD12_2526 ENOG4107T4V d-proline reductase NPD12_2527 ENOG4107T4V d-proline reductase NPD12_2529 ENOG41088D5 d-proline reductase NPD12_253 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein NPD12_2530 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) NPD12_2531 ENOG41088D5 d-proline reductase NPD12_2532 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) NPD12_2535 ENOG41088D5 d-proline reductase NPD12_2536 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) NPD12_2537 ENOG4108JUB Transcriptional regulator NPD12_254 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) NPD12_2542 ENOG4106H78 methyltransferase NPD12_2543 ENOG4105CB5 ATP-dependent DNA helicase recG NPD12_2544 ENOG4105DP4 dak2 domain fusion protein ylov NPD12_2545 ENOG4108ZAA Alkaline-shock protein NPD12_2549 ENOG4105DJV ribulose-phosphate 3-epimerase NPD12_2551 ENOG4105D9P serine threonine protein kinase NPD12_2552 ENOG4108ZF3 Phosphatase NPD12_2554 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B NPD12_2556 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) NPD12_2557 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) NPD12_2558 ENOG4105C25 Primosomal protein n' NPD12_2559 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase NPD12_2561 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) NPD12_2563 ENOG4105DSJ YicC domain protein NPD12_2564 ENOG4105HDK L-asparaginase NPD12_2565 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) NPD12_2566 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase NPD12_2569 ENOG4108UTW Plays a role in the regulation of phosphate uptake NPD12_257 ENOG4105CJT Mannose-1-phosphate guanylyltransferase NPD12_2570 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) NPD12_2571 ENOG4105E2Z phosphate ABC transporter (Permease NPD12_2572 ENOG4105C8U phosphate abc transporter NPD12_2573 ENOG4105CVA phosphate NPD12_2574 ENOG4105BZU Histidine kinase NPD12_2575 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_2576 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase NPD12_2578 ENOG4108BIK prc-barrel domain-containing protein NPD12_2579 ENOG4105E65 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NPD12_258 ENOG4105C8M UPF0272 protein NPD12_2580 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NPD12_2581 ENOG4105FFI sigma-e processing peptidase spoiiga NPD12_2582 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) NPD12_2583 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) NPD12_2586 ENOG4105CZX twitching motility protein NPD12_2588 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NPD12_2593 ENOG4105T2N Domain of unknown function (DUF2382) NPD12_2599 ENOG4105CJN penicillin-binding protein NPD12_260 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase NPD12_2601 ENOG4105CFP Peptidase U32 NPD12_2602 ENOG4108VQJ O-methyltransferase NPD12_2603 ENOG4105HHA aminodeoxychorismate lyase NPD12_2604 ENOG4105CI3 gtp-binding protein typa NPD12_2605 ENOG4105CN5 Metallo-Beta-Lactamase NPD12_2606 ENOG4105I3K Ferric uptake regulator, Fur family NPD12_2611 ENOG4105C02 permease NPD12_2613 ENOG4107RIU May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity) NPD12_2616 ENOG4105D1H recombination factor protein RarA NPD12_2617 ENOG4107RVV histidinol phosphate phosphatase, hisj family NPD12_2622 ENOG4105BZG amino acid carrier protein NPD12_2623 ENOG4105BZG amino acid carrier protein NPD12_2626 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii NPD12_2628 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) NPD12_263 ENOG4108TJN glycosyl transferase group 1 NPD12_2631 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) NPD12_264 ENOG4108W7E Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position (By similarity) NPD12_2642 ENOG4105DWK Membrane NPD12_2644 ENOG4105VPX protein, conserved in bacteria NPD12_2647 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) NPD12_2648 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) NPD12_2650 ENOG4105DB7 PHP domain protein NPD12_2651 ENOG4105DFM M18 family aminopeptidase NPD12_2652 ENOG4105D7N magnesium and cobalt transport protein CorA NPD12_2653 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase NPD12_2656 ENOG4108N5C SNARE associated Golgi protein-related protein NPD12_2661 ENOG4105CKK Glycosyl transferase, family 2 NPD12_2662 ENOG4105KHC sulfurtransferase NPD12_2663 ENOG4105CBT Fructose-1,6-bisphosphatase NPD12_2665 ENOG4105CNW domain protein NPD12_268 ENOG4108TJN glycosyl transferase group 1 NPD12_2687 ENOG4105CGA flagellar basal-body rod protein FlgG NPD12_2688 ENOG4105CGA flagellar basal-body rod protein FlgG NPD12_2691 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NPD12_2694 ENOG4105FZW flagellar biosynthesis regulator FlhF NPD12_2695 ENOG4105D7B Flagellar biosynthesis protein flha NPD12_2696 ENOG4105D00 flagellar biosynthetic protein flhB NPD12_2698 ENOG4105CN7 Flagellar biosynthetic protein FliP NPD12_27 ENOG4108K88 Membrane NPD12_270 ENOG4105XFA sporulation peptidase YabG NPD12_2701 ENOG4106VK6 Flagellar motor protein NPD12_2702 ENOG4107R0U MotA TolQ exbB proton channel NPD12_2703 ENOG41068WV flagellar FlbD family protein NPD12_2704 ENOG4108JQA flagellar NPD12_2706 ENOG410822I Flagellar hook capping protein NPD12_271 ENOG4105W42 Veg protein NPD12_2711 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) NPD12_2712 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) NPD12_2713 ENOG4105VQ0 flagellar hook-basal body complex protein fliE NPD12_2714 ENOG4108ZC9 flagellar basal-body rod protein flgc NPD12_2715 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) NPD12_2716 ENOG4105I03 Flagellin NPD12_2722 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) NPD12_2723 ENOG4108V3A UPF0421 protein NPD12_2728 ENOG4105D2T synthase NPD12_2729 ENOG4105F0R Cytidylyltransferase NPD12_273 ENOG4105DDG Cyanophycinase NPD12_2731 ENOG41066S7 Glycosyltransferase family 52 NPD12_2733 ENOG4105D5D udp-galactopyranose mutase NPD12_2734 ENOG4105D3Q Sugar transferase NPD12_2735 ENOG4107YJ4 chain length determinant protein NPD12_2736 ENOG4108RB3 Capsular polysaccharide biosynthesis protein NPD12_2737 ENOG4105HTX biosynthesis protein NPD12_2738 ENOG4108KGH TRANSCRIPTIONal NPD12_2742 ENOG4105FKZ Methyl-accepting chemotaxis NPD12_2743 ENOG4105I03 Flagellin NPD12_2752 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase NPD12_2753 ENOG4108IAJ Nad-dependent epimerase dehydratase NPD12_2754 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family NPD12_2757 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain NPD12_2758 ENOG4105D2T synthase NPD12_2760 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase NPD12_2761 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase NPD12_2763 ENOG41090QV Protein of unknown function DUF115 NPD12_2764 ENOG4105I03 Flagellin NPD12_2766 ENOG4107RT6 flagellar hook-associated NPD12_2767 ENOG4105MQ3 flagellar protein FliS NPD12_2773 ENOG4105E1Q flagellar hook-associated protein NPD12_2776 ENOG4105DD5 Flagellar motor switch protein NPD12_2777 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) NPD12_2778 ENOG4108V3W Chemotaxis protein, CheW NPD12_2779 ENOG4107YTP response regulator receiver protein NPD12_278 ENOG4108Q8B Spore germination protein NPD12_2781 ENOG4105CBS Chea signal transduction histidine kinase NPD12_2782 ENOG4105BZU Histidine kinase NPD12_2783 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) NPD12_2785 ENOG4108V3W Chemotaxis protein, CheW NPD12_2787 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane NPD12_2796 ENOG4105BZU Histidine kinase NPD12_2797 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) NPD12_280 ENOG4108ZXQ stage ii sporulation protein r NPD12_2803 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator NPD12_2804 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NPD12_2805 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) NPD12_2807 ENOG4105CKD glutathione-regulated potassium-efflux system protein NPD12_281 ENOG4108QBV Monogalactosyldiacylglycerol synthase NPD12_2812 ENOG4105CMR udp-glucose 4-epimerase NPD12_2813 ENOG4108Z29 Flavodoxin NPD12_2815 ENOG41075H3 AraC family transcriptional regulator NPD12_2816 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A NPD12_2818 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) NPD12_2819 ENOG4105K8R UPF0145 protein NPD12_282 ENOG4105MSI germination protein ypeb NPD12_2822 ENOG4105DVE abc transporter atp-binding protein NPD12_2823 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NPD12_2830 ENOG4105E1K spore germination protein NPD12_2833 ENOG4105C1J atp-dependent rna helicase NPD12_2836 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_2838 ENOG4108AC1 4fe-4s ferredoxin, iron-sulfur binding NPD12_2840 ENOG41069ER domain protein NPD12_2841 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer NPD12_2843 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NPD12_2844 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) NPD12_2847 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) NPD12_2848 ENOG4107SJI Dehydrogenase NPD12_2849 ENOG4105BZ8 glutamate synthase NPD12_2850 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) NPD12_2853 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) NPD12_2854 ENOG41081HM 2'-5' rna ligase NPD12_2856 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_2858 ENOG4105I3K Ferric uptake regulator, Fur family NPD12_286 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) NPD12_2862 ENOG4105CE4 GlcNAc 6-P deacetylase NPD12_2863 ENOG4105FDP GntR family transcriptional regulator NPD12_2864 ENOG4105CID antiterminator NPD12_2865 ENOG4105CI1 PTS System NPD12_2867 ENOG4107R73 Mate efflux family protein NPD12_2868 ENOG4105DIW FeS assembly protein SUFB NPD12_2869 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NPD12_2871 ENOG4105I3K Ferric uptake regulator, Fur family NPD12_2873 ENOG4105CNW domain protein NPD12_2874 ENOG4105C1G acyl-Coa dehydrogenase NPD12_2875 ENOG4105DQ6 Transposase NPD12_2879 ENOG4105ETZ PTS System NPD12_288 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) NPD12_2880 ENOG4105F3R pts system mannose fructose sorbose family iid NPD12_2882 ENOG4107QP7 CoA-transferase subunit A NPD12_2884 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase NPD12_2885 ENOG4108XHQ (2Fe-2S)-binding domain protein NPD12_2887 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding NPD12_2888 ENOG4105CS2 ec 3.2.1.21 NPD12_2889 ENOG4105CS2 ec 3.2.1.21 NPD12_2890 ENOG4107RWR Sodium hydrogen exchanger NPD12_2898 ENOG4105C5H ABC transporter NPD12_29 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_291 ENOG4105CBJ Metal-dependent enzyme NPD12_2911 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E NPD12_2913 ENOG4105BZ1 (ABC) transporter NPD12_2914 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) NPD12_2916 ENOG4105E0M Sulfatase NPD12_2917 ENOG4105EJ9 Membrane NPD12_2919 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) NPD12_2920 ENOG4108R6K riboflavin synthase, subunit alpha NPD12_2921 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) NPD12_2922 ENOG4105CIN aminoacyl-histidine dipeptidase NPD12_2923 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) NPD12_2924 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic NPD12_2926 ENOG4105C12 Phosphoribosylglycinamide synthetase NPD12_2928 ENOG4108V3E phosphoribosylglycinamide formyltransferase NPD12_2932 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) NPD12_2934 ENOG4107S4Y M20 DapE family protein YgeY NPD12_2935 ENOG4107UUR Chlorohydrolase aminohydrolase NPD12_2936 ENOG4105BZ8 glutamate synthase NPD12_2937 ENOG4105IW6 Carbamoyltransferase NPD12_2939 ENOG4105C2W permease NPD12_2940 ENOG4107RCH Diaminopropionate ammonia-lyase NPD12_2941 ENOG4108JUB Transcriptional regulator NPD12_2942 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC NPD12_2943 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) NPD12_2944 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family NPD12_2947 ENOG4105EHG Permease protein NPD12_2948 ENOG4105E0A ABC, transporter NPD12_2954 ENOG4105C7N Xanthine uracil vitamin C permease NPD12_2955 ENOG4105BZG amino acid carrier protein NPD12_2956 ENOG4105EEM helicase NPD12_296 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) NPD12_2960 ENOG4108ZGC gaf domain protein NPD12_2961 ENOG4105C37 (CBS) domain NPD12_2969 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NPD12_297 ENOG4107WAU Protein tyrosine phosphatase NPD12_2970 ENOG4105NBU tryptophan transport protein NPD12_2972 ENOG4107V6Q Cyclic nucleotide-binding domain NPD12_2977 ENOG4108QXE glycerophosphoryl diester phosphodiesterase NPD12_298 ENOG4108YZG isomerase NPD12_2980 ENOG4105C37 (CBS) domain NPD12_2983 ENOG4105EGD dinuclear metal center protein, YbgI family NPD12_2986 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NPD12_2987 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) NPD12_2988 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein NPD12_2990 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) NPD12_2992 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) NPD12_2993 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) NPD12_2998 ENOG4105CTJ Metal Dependent Phosphohydrolase NPD12_3 ENOG41082I2 s4 domain protein NPD12_3001 ENOG4105KTH gatB Yqey NPD12_3003 ENOG4107YU2 histidine triad (hIT) protein NPD12_3004 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) NPD12_3005 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) NPD12_3007 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) NPD12_3009 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ NPD12_3010 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) NPD12_3011 ENOG4105CSA Coproporphyrinogen iii oxidase NPD12_3015 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) NPD12_302 ENOG4105ESV Glycosyl transferase, family 4 NPD12_3027 ENOG4105XSJ toxin secretion phage lysis holin NPD12_303 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase NPD12_3033 ENOG41066EA baseplate J family protein NPD12_3041 ENOG4105FR7 XkdM protein, phage-like element PBSX NPD12_3042 ENOG4105PQS phage protein NPD12_305 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) NPD12_3055 ENOG41061CV Terminase small subunit NPD12_3065 ENOG4105C2M dna polymerase I NPD12_3078 ENOG4105VTR Integrase NPD12_3080 ENOG4105EM7 Selenocysteine-specific translation elongation factor NPD12_3082 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) NPD12_3085 ENOG4105DZ1 carboxypeptidase NPD12_3086 ENOG4108YBP pseudouridine synthase NPD12_3087 ENOG4105KME endoribonuclease L-psp NPD12_3088 ENOG4108KGH TRANSCRIPTIONal NPD12_3089 ENOG4108WF2 Metal Dependent Phosphohydrolase NPD12_3091 ENOG410812S Rna-binding protein NPD12_3096 ENOG4105C03 ribonuclease NPD12_3100 ENOG4105DR5 peptidase NPD12_3101 ENOG4105CNI cell division protein FtsW NPD12_3103 ENOG4107QMS site-determining protein NPD12_3104 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) NPD12_3105 ENOG4107RF6 penicillin-binding protein NPD12_3108 ENOG4105DFF Rod shape-determining protein mreb NPD12_3118 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) NPD12_3119 ENOG4105C2M dna polymerase I NPD12_3120 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase NPD12_314 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) NPD12_3155 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein NPD12_3165 ENOG4105D4P Coproporphyrinogen iii oxidase NPD12_3166 ENOG4105C5X domain protein NPD12_3168 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) NPD12_317 ENOG4105MT0 Sporulation transcriptional regulator spoiiid NPD12_3171 ENOG4107SBW Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) NPD12_3172 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) NPD12_3176 ENOG4105VIE preprotein translocase, subunit YajC NPD12_3183 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein NPD12_3188 ENOG4105VCQ rubredoxin NPD12_3189 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) NPD12_319 ENOG4108ZDA Sporulation protein YyaC NPD12_3190 ENOG4108UGV hypoxanthine phosphoribosyltransferase NPD12_3194 ENOG4105CZ3 stage V sporulation protein ad NPD12_3195 ENOG41090VF Stage v sporulation protein ac NPD12_3196 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NPD12_3198 ENOG41082AN stage II sporulation protein NPD12_32 ENOG4107ZE5 PPIases accelerate the folding of proteins NPD12_320 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) NPD12_3202 ENOG4105D3Q Sugar transferase NPD12_3204 ENOG4105CJR Integral membrane protein (MviN NPD12_3206 ENOG4105CPK Glycosyl transferase (Group 1 NPD12_3209 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase NPD12_3210 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) NPD12_3217 ENOG4107QQG Dehydrogenase NPD12_3222 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase NPD12_3225 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) NPD12_3226 ENOG4105CXN decarboxylase NPD12_3228 ENOG4107RE7 phosphate butyryltransferase NPD12_3230 ENOG4105EWC Purine nucleoside phosphorylase NPD12_3232 ENOG4105CFP Peptidase U32 NPD12_3236 ENOG4107TVC Glycosyl transferase, family 2 NPD12_3238 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) NPD12_3240 ENOG4108RWN rrna methyltransferase NPD12_3241 ENOG4107ZYR domain protein NPD12_3242 ENOG4105CZN Potassium uptake protein NPD12_3245 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) NPD12_3250 ENOG4105DA5 (ABC) transporter NPD12_3257 ENOG4108D32 Methyltransferase NPD12_3259 ENOG4108JQ7 (ABC) transporter NPD12_3261 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component NPD12_3262 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component NPD12_3263 ENOG4107QSI ABC, transporter NPD12_3264 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) NPD12_3265 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) NPD12_3266 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) NPD12_3267 ENOG4105CHM Aminotransferase NPD12_327 ENOG4105C7H Helicase, RecD TraA family NPD12_3277 ENOG41080E2 ribosomal-protein-alanine acetyltransferase NPD12_3278 ENOG4105C19 ABC transporter NPD12_3280 ENOG4105D2X ABC transporter substrate-binding protein NPD12_3283 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component NPD12_3287 ENOG4108J6I peptidase, M16 NPD12_3292 ENOG4105NBK UPF0345 protein NPD12_3293 ENOG4105II7 pyrroline-5-carboxylate reductase NPD12_3294 ENOG4105C6N Formate acetyltransferase NPD12_3295 ENOG4105F1A Pyruvate formate-lyase NPD12_3296 ENOG4105WBV Transcriptional regulator NPD12_3300 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) NPD12_3306 ENOG4105CIZ coA-substrate-specific enzyme activase NPD12_3308 ENOG4105C10 Electron transfer flavoprotein NPD12_3309 ENOG4105BZJ Electron transfer flavoprotein NPD12_3310 ENOG4105C1G acyl-Coa dehydrogenase NPD12_3311 ENOG4105CHU acetyl-coa acetyltransferase NPD12_3312 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase NPD12_3313 ENOG4105E39 Enoyl-CoA hydratase NPD12_3316 ENOG4105C7N Xanthine uracil vitamin C permease NPD12_3317 ENOG4105EQI Metal Dependent Phosphohydrolase NPD12_3322 ENOG4108QXE glycerophosphoryl diester phosphodiesterase NPD12_3323 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_3324 ENOG4105KY8 Rubrerythrin NPD12_3329 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) NPD12_3331 ENOG4105G5W regulator Fur family NPD12_3334 ENOG4105D29 Helix-turn-helix type 11 domain protein NPD12_3338 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) NPD12_3339 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) NPD12_3340 ENOG4108IUQ atp-dependent protease NPD12_3344 ENOG4107TRN Xylose isomerase domain protein TIM barrel NPD12_3347 ENOG4107W93 Dihydroorotate dehydrogenase NPD12_3348 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) NPD12_335 ENOG4108SAX Membrane NPD12_3353 ENOG4105CIZ coA-substrate-specific enzyme activase NPD12_3355 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase NPD12_3356 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase NPD12_3359 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component NPD12_3390 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) NPD12_3393 ENOG4105DEF Extracellular solute-binding protein, family 5 NPD12_34 ENOG4105CFQ glutamine synthetase NPD12_340 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase NPD12_3400 ENOG4105C4R Atp-dependent dna helicase NPD12_3401 ENOG4105KGF protein, YerC YecD NPD12_3403 ENOG4105E4C Lytic transglycosylase catalytic NPD12_3406 ENOG4107XJU UPF0178 protein NPD12_3411 ENOG4105C5I Dehydrogenase NPD12_3414 ENOG4105C10 Electron transfer flavoprotein NPD12_3415 ENOG4105BZJ Electron transfer flavoprotein NPD12_3416 ENOG4105C1G acyl-Coa dehydrogenase NPD12_3421 ENOG4105CEY Amp-dependent synthetase and ligase NPD12_3424 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) NPD12_3425 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) NPD12_3433 ENOG4105CDJ oxidoreductase FAD NAD(P)-binding domain protein NPD12_3435 ENOG4105C5H ABC transporter NPD12_3436 ENOG4105DY9 regulatoR NPD12_3437 ENOG4108HRK Histidine kinase NPD12_344 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) NPD12_3440 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) NPD12_3447 ENOG4105DSE periplasmic solute binding protein NPD12_3448 ENOG4105DHT Metal Dependent Phosphohydrolase NPD12_3449 ENOG4105K8N protein family UPF0079, ATPase NPD12_3450 ENOG41072GX Peptidase M22 Glycoprotease NPD12_3451 ENOG410801F ribosomal-protein-alanine acetyltransferase NPD12_3458 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) NPD12_3459 ENOG410667J hydrolase NPD12_3460 ENOG4105C31 Tryptophanyl-tRNA synthetase NPD12_3461 ENOG4105MAX Superoxide reductase NPD12_347 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) NPD12_3470 ENOG4105CJ1 ABC, transporter NPD12_3475 ENOG4105BZ1 (ABC) transporter NPD12_3476 ENOG4105E2V Glycosyltransferase 36 NPD12_3479 ENOG4105DFM M18 family aminopeptidase NPD12_3482 ENOG4105EEM helicase NPD12_3483 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) NPD12_3484 ENOG4107QSE Dipeptidase NPD12_3486 ENOG4105VC4 domain protein NPD12_3489 ENOG4105DA5 (ABC) transporter NPD12_3491 ENOG4105JVQ RNA Polymerase NPD12_3492 ENOG4105CHH sulfate transporter NPD12_3496 ENOG4105CJ1 ABC, transporter NPD12_3500 ENOG4105RD7 BadF BadG BcrA BcrD NPD12_3501 ENOG4105VCP PTS System NPD12_3503 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family NPD12_3504 ENOG4105CK1 PTS System NPD12_3505 ENOG4105F8D glycoside hydrolase family 4 NPD12_3507 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) NPD12_351 ENOG4105D2N Aldolase NPD12_3510 ENOG4105X5K response regulator receiver protein NPD12_3511 ENOG4105KVH Transcriptional regulator NPD12_3516 ENOG4105VUF Transcriptional regulator NPD12_3517 ENOG4107ZT6 cytidine deaminase NPD12_3519 ENOG4105UEI Transcriptional Regulator AraC Family NPD12_3520 ENOG4105NAE bifunctional deaminase-reductase domain protein NPD12_3522 ENOG41062ES Transcriptional regulator NPD12_3523 ENOG4108Z1Z gCN5-related N-acetyltransferase NPD12_3524 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) NPD12_3527 ENOG4105CA9 Pyruvate kinase NPD12_3529 ENOG4105C0B DNA polymerase III (alpha subunit) NPD12_353 ENOG4105H67 Protein of unknown function (DUF421) NPD12_3531 ENOG4105CHW UPF0052 protein NPD12_3536 ENOG4107K5X Membrane-bound metal-dependent hydrolase NPD12_3538 ENOG4105CJN penicillin-binding protein NPD12_354 ENOG4105C22 threonyL-tRNA synthetase NPD12_3540 ENOG4105TV9 FHA Domain-Containing protein NPD12_3541 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) NPD12_3543 ENOG4105DZP Membrane-associated zinc metalloprotease NPD12_3545 ENOG4105CRP Part of the ABC transporter FtsEX involved in NPD12_3546 ENOG4105CAK Cell division ATP-binding protein ftsE NPD12_3547 ENOG4108JYZ YitT family NPD12_3550 ENOG4108HHA Transketolase NPD12_3553 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) NPD12_3555 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) NPD12_3556 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) NPD12_3559 ENOG4107U9T Pfam:Ribonuclease_BN NPD12_356 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase NPD12_3564 ENOG4108Z6Z Transcriptional regulator NPD12_3567 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) NPD12_3568 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) NPD12_3569 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) NPD12_357 ENOG41080XP Cbs domain NPD12_3570 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 NPD12_3571 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase NPD12_3572 ENOG4105VI0 Pts system, glucitol sorbitol-specific NPD12_3573 ENOG4105DZY Pts system, glucitol sorbitol-specific NPD12_3574 ENOG410787A Pts system, glucitol sorbitol-specific NPD12_3576 ENOG4107WTH Galactitol-1-phosphate dehydrogenase NPD12_3577 ENOG4105DKT Transcriptional regulator NPD12_358 ENOG4105CBD Diacylglycerol kinase NPD12_3581 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein NPD12_3584 ENOG4105CKM Branched-chain carboxylic acid kinase NPD12_3585 ENOG4107RE7 phosphate butyryltransferase NPD12_3586 ENOG4105CKM Branched-chain carboxylic acid kinase NPD12_3587 ENOG4105DZ0 fad dependent oxidoreductase NPD12_3589 ENOG4105C8B TIGR00159 family NPD12_3590 ENOG4105F0V Cell wall hydrolase NPD12_3591 ENOG4105C3M thioredoxin reductase NPD12_3592 ENOG4105K63 Thioredoxin NPD12_3593 ENOG4105DYB Isoaspartyl dipeptidase NPD12_3596 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) NPD12_3597 ENOG4108JUB Transcriptional regulator NPD12_3600 ENOG4107GFK fumarate NPD12_3601 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase NPD12_3605 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) NPD12_3606 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) NPD12_3607 ENOG4108JJB ABC transporter NPD12_3608 ENOG4108JJB ABC transporter NPD12_3619 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) NPD12_363 ENOG4105C6T cysteine synthase NPD12_3634 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) NPD12_364 ENOG4105D7W serine acetyltransferase NPD12_3645 ENOG4105XPM ribosomal protein NPD12_3649 ENOG4108VZM 50s ribosomal protein L10 NPD12_365 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) NPD12_3652 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) NPD12_3658 ENOG4105QIV RNA polymerase NPD12_3660 ENOG4105C2N RNA methyltransferase TrmH family group 3 NPD12_3661 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) NPD12_3662 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) NPD12_3664 ENOG4105C7B Threonine dehydratase NPD12_3665 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) NPD12_3667 ENOG4105CTP PilT protein domain protein NPD12_367 ENOG4105CSM endonuclease III NPD12_3671 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) NPD12_3674 ENOG4108Z0C Uvrb UvrC protein NPD12_3677 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) NPD12_368 ENOG4105C6K Malic enzyme NPD12_3691 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) NPD12_3695 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) NPD12_3698 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) NPD12_3699 ENOG4108UGV hypoxanthine phosphoribosyltransferase NPD12_37 ENOG4105Q2H domain protein NPD12_3700 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) NPD12_3709 ENOG41060GV RNA binding s1 domain protein NPD12_371 ENOG4105DER m42 family NPD12_3714 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) NPD12_372 ENOG41073R8 VanW family NPD12_373 ENOG41073R8 VanW family NPD12_374 ENOG4105F6S Spore photoproduct lyase NPD12_375 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) NPD12_376 ENOG4105EPR degv family NPD12_377 ENOG4105DIH basic membrane NPD12_378 ENOG4108JQ9 ABC transporter NPD12_379 ENOG4105UIB (ABC) transporter NPD12_381 ENOG4107VMI polysaccharide deacetylase NPD12_3812 ENOG4105MT0 Sporulation transcriptional regulator spoiiid NPD12_382 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) NPD12_39 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving NPD12_390 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) NPD12_395 ENOG4105CK1 PTS System NPD12_396 ENOG4105F8D glycoside hydrolase family 4 NPD12_398 ENOG4105VCP PTS System NPD12_401 ENOG41063TF transcriptional regulator (AraC NPD12_404 ENOG4105I03 Flagellin NPD12_406 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NPD12_41 ENOG4105EQ0 Major Facilitator superfamily NPD12_410 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein NPD12_412 ENOG4108IQI permease NPD12_417 ENOG4105NAE bifunctional deaminase-reductase domain protein NPD12_418 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) NPD12_420 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding NPD12_424 ENOG4105CZ3 stage V sporulation protein ad NPD12_425 ENOG41090VF Stage v sporulation protein ac NPD12_426 ENOG4108QG2 Membrane NPD12_43 ENOG4108JGH Tetr family transcriptional regulator NPD12_430 ENOG4107QIV Cytochrome c biogenesis protein NPD12_433 ENOG4105EB3 Histidine kinase NPD12_434 ENOG4105DNP FAD linked oxidase domain protein NPD12_435 ENOG4105F8D glycoside hydrolase family 4 NPD12_436 ENOG4105CI1 PTS System NPD12_437 ENOG4105HX0 Transcriptional regulator NPD12_439 ENOG4105C5Y PTS System NPD12_44 ENOG4105HFT AraC family transcriptional regulator NPD12_441 ENOG4105EWM Histidine kinase NPD12_442 ENOG4105C19 ABC transporter NPD12_444 ENOG4105CI1 PTS System NPD12_445 ENOG4105F8D glycoside hydrolase family 4 NPD12_448 ENOG4105VEQ Cold shock protein NPD12_45 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) NPD12_450 ENOG4108Z40 Transcriptional regulator NPD12_451 ENOG4107ZXU DSBA oxidoreductase NPD12_452 ENOG4108RYK Nad-dependent epimerase dehydratase NPD12_453 ENOG4108Q3X Transcriptional regulator NPD12_454 ENOG4105CI1 PTS System NPD12_456 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane NPD12_457 ENOG4105C01 Dihydroxy-acid dehydratase NPD12_459 ENOG4105D7K pfkb domain protein NPD12_46 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase NPD12_462 ENOG4105F3H Histidine kinase NPD12_463 ENOG4105CKK Glycosyl transferase, family 2 NPD12_465 ENOG4105EDW glycosyl transferase, family 39 NPD12_466 ENOG4105E7U AraC family transcriptional regulator NPD12_468 ENOG4105EHG Permease protein NPD12_469 ENOG4105E0A ABC, transporter NPD12_47 ENOG4105G0K glycine radical enzyme YjjI family NPD12_472 ENOG4108V5C ABC transporter NPD12_473 ENOG4105T16 Transcriptional regulator (AraC family) NPD12_474 ENOG4108V5C ABC transporter NPD12_475 ENOG4105DQ5 transport system permease protein NPD12_476 ENOG4105EHG Permease protein NPD12_477 ENOG4105E0A ABC, transporter NPD12_478 ENOG4105BZ1 (ABC) transporter NPD12_48 ENOG41076CZ activating enzyme NPD12_484 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) NPD12_489 ENOG41067MG lrgb family NPD12_5 ENOG4108IY2 MazG family NPD12_50 ENOG4107QW8 radical SAM domain protein NPD12_500 ENOG4105BZU Histidine kinase NPD12_504 ENOG4105BZU Histidine kinase NPD12_505 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) NPD12_506 ENOG4105CFF transcriptional regulator NPD12_507 ENOG4105E5D amino acid NPD12_508 ENOG4105DC7 peptidase M24 NPD12_516 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NPD12_517 ENOG4105BZU Histidine kinase NPD12_52 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) NPD12_521 ENOG4105BZU Histidine kinase NPD12_526 ENOG4105C9B Cysteine desulfurase NPD12_527 ENOG4105HMI Membrane NPD12_530 ENOG4105BZU Histidine kinase NPD12_531 ENOG4107RUZ Sss sodium solute transporter superfamily NPD12_532 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) NPD12_533 ENOG4105D6A Electron transport complex NPD12_534 ENOG41080WF Electron transport complex, RnfABCDGE type, G subunit NPD12_535 ENOG4105DZB Electron transport complex NPD12_536 ENOG4105DGN Electron transport complex NPD12_537 ENOG4107SVV electron transport complex, RnfABCDGE type, B subunit NPD12_541 ENOG4105CJ2 (LipO)protein NPD12_549 ENOG4105CVA phosphate NPD12_55 ENOG4105CG5 Glycosyl transferase (Group 1 NPD12_550 ENOG4105C8U phosphate abc transporter NPD12_552 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) NPD12_554 ENOG4107QTZ amino acid NPD12_558 ENOG4108UUM single-stranded DNA-binding protein NPD12_56 ENOG4105DB7 PHP domain protein NPD12_562 ENOG4105CPI Metal Dependent Phosphohydrolase NPD12_563 ENOG4107ZXI Rhomboid family NPD12_565 ENOG4105IU0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) NPD12_573 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit NPD12_574 ENOG4105F1K Glutamine amidotransferase NPD12_575 ENOG4105DMS mur ligase NPD12_576 ENOG4105DG6 mannose-6-phosphate isomerase NPD12_578 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) NPD12_585 ENOG4105E8R UPF0173 metal-dependent hydrolase NPD12_587 ENOG4107SDT Homocitrate synthase NPD12_588 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) NPD12_589 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) NPD12_59 ENOG4105DUM transcriptional regulator, lysR family NPD12_590 ENOG4105CDA abc transporter atp-binding protein NPD12_591 ENOG4107S6Z Na H antiporter NPD12_592 ENOG4105WG9 Conserved Protein NPD12_6 ENOG4105CKP Polysaccharide Biosynthesis Protein NPD12_60 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin NPD12_600 ENOG4108IG5 Transcriptional regulator NPD12_603 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) NPD12_607 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_613 ENOG4105E5Q amino acid AbC transporter NPD12_614 ENOG4105E89 ABC transporter NPD12_615 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NPD12_616 ENOG4105D58 Diguanylate phosphodiesterase NPD12_619 ENOG4105DWF phosphomethylpyrimidine kinase NPD12_621 ENOG4105CP9 extracellular ligand-binding receptor NPD12_622 ENOG4105C32 Amino acid ABC transporter (Permease) NPD12_623 ENOG4105CF8 branched-chain amino acid ABC transporter, permease NPD12_624 ENOG4105C0Z ABC transporter NPD12_625 ENOG4108IV0 ABC, transporter NPD12_63 ENOG4108FRU Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) NPD12_631 ENOG4105HA9 of methanol dehydrogenase type NPD12_635 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NPD12_636 ENOG4105VMP Transcriptional regulator NPD12_639 ENOG4105EYH Exonuclease NPD12_644 ENOG4105C59 p-type ATPase NPD12_65 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase NPD12_650 ENOG4108IAB Phoh family NPD12_651 ENOG4108HQ0 Exopolysaccharide biosynthesis protein NPD12_659 ENOG4105CJ1 ABC, transporter NPD12_662 ENOG4108Z4T Peptidase M50 NPD12_668 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) NPD12_669 ENOG4105CHR reductase NPD12_672 ENOG4105E5G Alpha beta hydrolase fold NPD12_673 ENOG4105XJC Two component transcriptional regulator (Winged helix family NPD12_674 ENOG4105CPI Metal Dependent Phosphohydrolase NPD12_675 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_676 ENOG410812K response regulator receiver protein NPD12_677 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) NPD12_678 ENOG4105DVT helicase NPD12_68 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) NPD12_684 ENOG410828M hemerythrin-like, metal-binding protein NPD12_69 ENOG4105CHR reductase NPD12_694 ENOG4105BZ1 (ABC) transporter NPD12_697 ENOG4105C19 ABC transporter NPD12_7 ENOG4108M14 stage v sporulation protein t NPD12_70 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase NPD12_700 ENOG4105C0X amino acid NPD12_701 ENOG4108VVK transcriptional Regulator, AsnC NPD12_703 ENOG4105D5Q Arginine ornithine antiporter NPD12_704 ENOG4105D5Q Arginine ornithine antiporter NPD12_705 ENOG4108Z0R Transferase NPD12_706 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 NPD12_708 ENOG4105CAH Chromate NPD12_709 ENOG4105FGV Chromate NPD12_71 ENOG4105EA8 2-Nitropropane dioxygenase NPD12_710 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) NPD12_712 ENOG4108DWA Nad synthetase NPD12_715 ENOG4107RAQ aminopeptidase NPD12_722 ENOG4105D22 carbon starvation protein NPD12_725 ENOG4105C5H ABC transporter NPD12_726 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) NPD12_728 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving NPD12_730 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family NPD12_731 ENOG4105CZV ABC transporter NPD12_734 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_736 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) NPD12_737 ENOG4105F38 ABC transporter, permease NPD12_738 ENOG4105D38 putrescine abc transporter NPD12_740 ENOG4107QJT sodium dicarboxylate symporter NPD12_749 ENOG4105DDN Pentapeptide repeat-containing protein NPD12_750 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) NPD12_754 ENOG4105DY9 regulatoR NPD12_76 ENOG4105DR5 peptidase NPD12_762 ENOG4105BZ1 (ABC) transporter NPD12_766 ENOG4105C19 ABC transporter NPD12_770 ENOG4105EPR degv family NPD12_772 ENOG4105E0M Sulfatase NPD12_774 ENOG4105D9N nucleoside NPD12_780 ENOG41086D8 Transcriptional regulator NPD12_784 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_785 ENOG4105C08 Histidine kinase NPD12_786 ENOG4108VXD carboxy-peptidase NPD12_788 ENOG4105BZU Histidine kinase NPD12_791 ENOG4105BZU Histidine kinase NPD12_792 ENOG4105CNI cell division protein FtsW NPD12_793 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase NPD12_795 ENOG4105BZ1 (ABC) transporter NPD12_797 ENOG41062JF Transcriptional regulator NPD12_799 ENOG4108Z7R Chaperone CsaA NPD12_800 ENOG4105CF7 AraC family transcriptional regulator NPD12_801 ENOG4108IMY Transcriptional regulator NPD12_803 ENOG4105DY9 regulatoR NPD12_806 ENOG4105CE7 Amidase, hydantoinase carbamoylase family NPD12_808 ENOG4105C98 muts2 protein NPD12_814 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family NPD12_816 ENOG4105C1J atp-dependent rna helicase NPD12_819 ENOG4105C0R drug resistance transporter emrb qaca subfamily NPD12_825 ENOG4108UB4 uncharacterized protein ygjQ NPD12_826 ENOG4108F3G Type I restriction-modification system, R subunit NPD12_827 ENOG4105M6F mutator MutT protein NPD12_830 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) NPD12_832 ENOG4105CID antiterminator NPD12_833 ENOG4105C5Y PTS System NPD12_834 ENOG4105DB7 PHP domain protein NPD12_835 ENOG4105IJJ transcriptional regulator, crp fnr family NPD12_836 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center NPD12_837 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) NPD12_844 ENOG4105C7J ABC transporter, permease NPD12_845 ENOG4108JJB ABC transporter NPD12_853 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) NPD12_854 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) NPD12_859 ENOG4107SCJ type I restriction enzyme EcoKI subunit R NPD12_863 ENOG4105DQ5 transport system permease protein NPD12_864 ENOG4105EHG Permease protein NPD12_865 ENOG4105E0A ABC, transporter NPD12_867 ENOG4105D0B Nitrogenase protein alpha chain NPD12_869 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_873 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor NPD12_874 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor NPD12_876 ENOG4105DF9 Lipoate-protein, ligase NPD12_881 ENOG4105CK6 Two component transcriptional regulator (Winged helix family NPD12_882 ENOG4105BZU Histidine kinase NPD12_883 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NPD12_887 ENOG4108DMH HTH_ARAC NPD12_891 ENOG4105VZ8 Transcriptional regulator NPD12_894 ENOG4105W1Y Transcriptional regulator NPD12_898 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) NPD12_899 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) NPD12_9 ENOG4108JA2 transcriptioN-repair coupling factor NPD12_900 ENOG4105EEM helicase NPD12_903 ENOG41086D8 Transcriptional regulator NPD12_906 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) NPD12_907 ENOG4105C8Q Methyl-accepting chemotaxis NPD12_909 ENOG4105C5H ABC transporter NPD12_913 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) NPD12_914 ENOG4105C28 cystathionine NPD12_915 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) NPD12_917 ENOG4108I0C methyltransferase NPD12_918 ENOG41086D8 Transcriptional regulator NPD12_92 ENOG4105CBX hi0933 family NPD12_923 ENOG4108IMY Transcriptional regulator NPD12_940 ENOG4105D6J arsenicaL-resistance protein NPD12_942 ENOG41089UC methyltransferase, type 11 NPD12_956 ENOG4105DWF phosphomethylpyrimidine kinase NPD12_959 ENOG4105CJ1 ABC, transporter NPD12_961 ENOG4105DPZ Two component transcriptional regulator (Winged helix family NPD12_964 ENOG41086D8 Transcriptional regulator NPD12_968 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) NPD12_972 ENOG4105BZU Histidine kinase NPD12_974 ENOG4108MES Periplasmic binding protein NPD12_975 ENOG4105DQ5 transport system permease protein NPD12_976 ENOG4108IHU transport system permease protein NPD12_977 ENOG4105E0A ABC, transporter NPD12_980 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) NPD12_981 ENOG4105KHC sulfurtransferase NPD12_99 ENOG4105CDU Replicative dna helicase NPD12_999 ENOG4105CI2 imidazolone-5-propionate hydrolase