locus-tag	class	description
NPD12_10	COG0193	aminoacyl-tRNA hydrolase activity
NPD12_100	COG1067	ATP-dependent peptidase activity
NPD12_100	COG0470	DNA polymerase III
NPD12_1000	COG1114	Component of the transport system for branched-chain amino acids
NPD12_1003	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NPD12_1004	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NPD12_1005	COG0406	alpha-ribazole phosphatase activity
NPD12_1006	COG2720	vancomycin resistance protein
NPD12_1013	COG0720	synthase
NPD12_1014	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NPD12_1016	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NPD12_1016	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NPD12_1017	COG0071	Belongs to the small heat shock protein (HSP20) family
NPD12_1018	COG2226	methyltransferase
NPD12_1019	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPD12_102	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NPD12_1022	COG1595	DNA-templated transcription, initiation
NPD12_1027	COG1131	(ABC) transporter
NPD12_1028	COG3620	sequence-specific DNA binding
NPD12_1031	COG2267	carboxylic ester hydrolase activity
NPD12_1036	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NPD12_1036	COG0456	acetyltransferase
NPD12_1039	COG1741	Belongs to the pirin family
NPD12_1040	COG1733	regulation of RNA biosynthetic process
NPD12_1041	COG0778	Nitroreductase
NPD12_1043	COG2140	Oxalate decarboxylase
NPD12_1044	COG1611	Belongs to the LOG family
NPD12_1046	COG0583	DNA-binding transcription factor activity
NPD12_1047	COG0519	Catalyzes the synthesis of GMP from XMP
NPD12_1049	COG2378	regulation of single-species biofilm formation
NPD12_1054	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_1056	COG0778	Nitroreductase
NPD12_1058	COG1733	regulation of RNA biosynthetic process
NPD12_1060	COG3711	transcriptional antiterminator
NPD12_1061	COG1263	PTS System
NPD12_1061	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_1061	COG2190	(PTS) system
NPD12_1062	COG2723	6-phospho-beta-galactosidase activity
NPD12_1069	COG2207	Transcriptional regulator
NPD12_107	COG0360	Binds together with S18 to 16S ribosomal RNA
NPD12_1077	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NPD12_1079	COG1376	ErfK ybiS ycfS ynhG family protein
NPD12_108	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NPD12_1086	COG0577	efflux transmembrane transporter activity
NPD12_1086	COG1136	(ABC) transporter
NPD12_1088	COG5002	protein histidine kinase activity
NPD12_1089	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPD12_1090	COG1268	BioY protein
NPD12_1094	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NPD12_1097	COG0789	Transcriptional regulator
NPD12_1099	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NPD12_11	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPD12_110	COG0668	transmembrane transport
NPD12_1100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NPD12_1108	COG0113	porphobilinogen synthase activity
NPD12_1115	COG0454	-acetyltransferase
NPD12_1117	COG3177	Filamentation induced by cAMP protein fic
NPD12_1118	COG0778	Nitroreductase
NPD12_113	COG0628	permease
NPD12_1132	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NPD12_1132	COG1648	precorrin-2 dehydrogenase activity
NPD12_1133	COG2875	Belongs to the precorrin methyltransferase family
NPD12_1140	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NPD12_1142	COG2116	formate transmembrane transporter activity
NPD12_1145	COG2221	Nitrite and sulphite reductase 4Fe-4S
NPD12_1151	COG0745	RESPONSE REGULATOR receiver
NPD12_1152	COG2205	protein histidine kinase activity
NPD12_1153	COG1120	ATPase activity
NPD12_1154	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_1155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPD12_1156	COG1011	Hydrolase
NPD12_1160	COG0583	DNA-binding transcription factor activity
NPD12_1164	COG2376	Dihydroxyacetone kinase
NPD12_1166	COG2207	Transcriptional regulator
NPD12_1166	COG0662	Cupin 2, conserved barrel domain protein
NPD12_1167	COG0454	-acetyltransferase
NPD12_117	COG1475	DNA binding
NPD12_1170	COG0656	L-ascorbic acid biosynthetic process
NPD12_1177	COG5002	protein histidine kinase activity
NPD12_1179	COG1876	peptidase activity
NPD12_118	COG1192	Involved in chromosome partitioning
NPD12_1185	COG0514	ATP-dependent DNA helicase (RecQ)
NPD12_1186	COG1592	Rubrerythrin
NPD12_1186	COG1773	rubredoxin
NPD12_1187	COG0622	Phosphoesterase
NPD12_1188	COG0745	RESPONSE REGULATOR receiver
NPD12_119	COG1475	DNA binding
NPD12_1192	COG0602	queuosine metabolic process
NPD12_1195	COG1620	l-lactate permease
NPD12_1196	COG3875	lactate racemase activity
NPD12_1197	COG2086	electron transfer activity
NPD12_1198	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NPD12_1199	COG0277	FAD linked oxidase domain protein
NPD12_12	COG5002	protein histidine kinase activity
NPD12_120	COG0357	Ribosomal RNA small subunit methyltransferase G
NPD12_1204	COG0436	Aminotransferase
NPD12_1206	COG1846	Transcriptional regulator
NPD12_1207	COG0789	Transcriptional regulator
NPD12_1207	COG4978	Transcriptional regulator
NPD12_1209	COG0017	Asparaginyl-tRNA synthetase
NPD12_1215	COG1011	Hydrolase
NPD12_1218	COG0583	DNA-binding transcription factor activity
NPD12_1219	COG0456	acetyltransferase
NPD12_1221	COG1918	ferrous iron import across plasma membrane
NPD12_1221	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NPD12_1225	COG1876	peptidase activity
NPD12_1228	COG5002	protein histidine kinase activity
NPD12_123	COG1847	R3H domain protein
NPD12_1230	COG2124	cytochrome p450
NPD12_1233	COG0745	RESPONSE REGULATOR receiver
NPD12_1234	COG5002	protein histidine kinase activity
NPD12_1237	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_1238	COG4605	iron ion homeostasis
NPD12_1239	COG4604	ABC transporter, ATP-binding protein
NPD12_1240	COG4607	ABC-type enterochelin transport system periplasmic component
NPD12_1242	COG1132	(ABC) transporter
NPD12_1243	COG1132	(ABC) transporter
NPD12_1245	COG3279	Response regulator of the LytR AlgR family
NPD12_125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NPD12_1251	COG1331	Highly conserved protein containing a thioredoxin domain
NPD12_1252	COG4129	membrane
NPD12_1258	COG0488	(ABC) transporter
NPD12_1263	COG0446	pyridine nucleotide-disulphide oxidoreductase
NPD12_1265	COG2271	Major facilitator Superfamily
NPD12_1266	COG0018	arginyl-trna synthetase
NPD12_1268	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NPD12_1269	COG2239	Acts as a magnesium transporter
NPD12_1275	COG3979	chitinase
NPD12_1278	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NPD12_1279	COG2011	ABC-type metal ion transport system permease component
NPD12_128	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NPD12_1280	COG1464	Belongs to the NlpA lipoprotein family
NPD12_1282	COG1464	Belongs to the NlpA lipoprotein family
NPD12_1283	COG1473	amidohydrolase
NPD12_1285	COG2186	Transcriptional regulator
NPD12_1286	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPD12_129	COG0592	DNA-directed DNA polymerase activity
NPD12_1290	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NPD12_1292	COG0617	tRNA 3'-terminal CCA addition
NPD12_1293	COG1012	belongs to the aldehyde dehydrogenase family
NPD12_1294	COG1115	amino acid carrier protein
NPD12_1295	COG1115	amino acid carrier protein
NPD12_1296	COG1846	Transcriptional regulator
NPD12_1297	COG0534	Mate efflux family protein
NPD12_13	COG0745	RESPONSE REGULATOR receiver
NPD12_1300	COG4134	Bacterial extracellular solute-binding protein
NPD12_1302	COG1176	ABC-type spermidine putrescine transport system, permease component I
NPD12_1305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPD12_1308	COG2431	L-lysine efflux transmembrane transporter activity
NPD12_1309	COG0110	maltose O-acetyltransferase activity
NPD12_1313	COG5002	protein histidine kinase activity
NPD12_1317	COG2239	Acts as a magnesium transporter
NPD12_1319	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPD12_1323	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NPD12_1326	COG1335	isochorismatase
NPD12_133	COG0187	DNA topoisomerase II activity
NPD12_1333	COG2897	thiosulfate sulfurtransferase activity
NPD12_1335	COG0628	permease
NPD12_134	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NPD12_1346	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NPD12_1346	COG0539	negative regulation of cytoplasmic translation
NPD12_1347	COG0824	Thioesterase
NPD12_1350	COG4120	Belongs to the binding-protein-dependent transport system permease family
NPD12_1351	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NPD12_1354	COG0697	spore germination
NPD12_1355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPD12_1357	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NPD12_1358	COG3404	Formiminotransferase-cyclodeaminase
NPD12_1359	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NPD12_1360	COG0561	phosphatase activity
NPD12_1365	COG1959	2 iron, 2 sulfur cluster binding
NPD12_1370	COG1606	tRNA processing
NPD12_1375	COG3290	protein histidine kinase activity
NPD12_1378	COG0584	glycerophosphoryl diester phosphodiesterase
NPD12_1382	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NPD12_1383	COG1231	oxidoreductase activity
NPD12_1387	COG1940	carbohydrate kinase activity
NPD12_1390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NPD12_1392	COG1131	(ABC) transporter
NPD12_1398	COG5001	Diguanylate cyclase
NPD12_1398	COG3300	MHYT domain
NPD12_1400	COG1760	l-serine dehydratase
NPD12_1403	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NPD12_1404	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NPD12_141	COG1827	regulation of RNA biosynthetic process
NPD12_1410	COG1136	(ABC) transporter
NPD12_1410	COG0577	efflux transmembrane transporter activity
NPD12_1412	COG1136	(ABC) transporter
NPD12_1413	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPD12_1414	COG0601	transmembrane transport
NPD12_1418	COG3546	catalase activity
NPD12_1419	COG4632	Exopolysaccharide biosynthesis protein
NPD12_1419	COG5434	Belongs to the glycosyl hydrolase 28 family
NPD12_142	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
NPD12_1423	COG0756	dUTP diphosphatase activity
NPD12_1430	COG1309	transcriptional regulator
NPD12_1432	COG1131	(ABC) transporter
NPD12_1436	COG1115	amino acid carrier protein
NPD12_1438	COG1395	domain, Protein
NPD12_1442	COG1012	belongs to the aldehyde dehydrogenase family
NPD12_1446	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPD12_1447	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPD12_1456	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NPD12_1457	COG0582	viral genome integration into host DNA
NPD12_1477	COG1694	Mazg nucleotide pyrophosphohydrolase
NPD12_1484	COG3728	DNA packaging
NPD12_15	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NPD12_1506	COG3299	homolog of phage Mu protein gp47
NPD12_1518	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NPD12_1520	COG0235	Class ii aldolase
NPD12_1521	COG1349	DNA-binding transcription factor activity
NPD12_1523	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NPD12_1524	COG2323	membrane
NPD12_153	COG0688	phosphatidylethanolamine metabolic process
NPD12_1534	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NPD12_1535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NPD12_1536	COG2080	2 iron, 2 sulfur cluster binding
NPD12_1537	COG0590	tRNA wobble adenosine to inosine editing
NPD12_1542	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NPD12_1543	COG1115	amino acid carrier protein
NPD12_1545	COG5298	Protein conserved in bacteria
NPD12_1546	COG1215	transferase activity, transferring glycosyl groups
NPD12_155	COG1131	(ABC) transporter
NPD12_1551	COG1937	Protein conserved in bacteria
NPD12_1552	COG2217	Heavy metal translocating P-type atpase
NPD12_1553	COG2608	mercury ion transmembrane transporter activity
NPD12_1554	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NPD12_1555	COG1132	(ABC) transporter
NPD12_1559	COG5002	protein histidine kinase activity
NPD12_1578	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NPD12_1580	COG0569	domain protein
NPD12_1582	COG0210	DNA helicase
NPD12_1582	COG0210	DNA helicase
NPD12_1584	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_1585	COG3773	Cell wall hydrolase
NPD12_1587	COG2385	sporulation resulting in formation of a cellular spore
NPD12_1587	COG2247	cell wall binding repeat
NPD12_1588	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_1588	COG2190	(PTS) system
NPD12_1588	COG1263	PTS System
NPD12_1589	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NPD12_159	COG0688	phosphatidylethanolamine metabolic process
NPD12_1592	COG1151	hydroxylamine reductase activity
NPD12_1594	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NPD12_1595	COG0745	RESPONSE REGULATOR receiver
NPD12_1597	COG0577	efflux transmembrane transporter activity
NPD12_1598	COG1136	(ABC) transporter
NPD12_1600	COG1132	(ABC) transporter
NPD12_1601	COG1132	(ABC) transporter
NPD12_1603	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NPD12_1605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPD12_1606	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_1607	COG1120	ATPase activity
NPD12_1609	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
NPD12_1610	COG1737	Transcriptional regulator
NPD12_1612	COG1263	PTS System
NPD12_1612	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_1620	COG0840	transmembrane signaling receptor activity
NPD12_1622	COG0601	transmembrane transport
NPD12_1623	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPD12_1624	COG0444	Belongs to the ABC transporter superfamily
NPD12_1625	COG4608	Belongs to the ABC transporter superfamily
NPD12_1627	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NPD12_1628	COG1121	(ABC) transporter
NPD12_1629	COG0803	Belongs to the bacterial solute-binding protein 9 family
NPD12_1632	COG3706	GGDEF domain
NPD12_1635	COG1116	anion transmembrane transporter activity
NPD12_1636	COG0735	belongs to the Fur family
NPD12_1639	COG1234	tRNA 3'-trailer cleavage
NPD12_164	COG0626	cystathionine gamma-synthase activity
NPD12_1640	COG0531	amino acid
NPD12_1642	COG4585	Histidine kinase
NPD12_1643	COG2197	response regulator
NPD12_1644	COG1131	(ABC) transporter
NPD12_1650	COG1278	Cold shock
NPD12_1651	COG2195	Cleaves the N-terminal amino acid of tripeptides
NPD12_1654	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NPD12_1655	COG1136	(ABC) transporter
NPD12_1656	COG0577	efflux transmembrane transporter activity
NPD12_1658	COG0745	RESPONSE REGULATOR receiver
NPD12_1659	COG2205	protein histidine kinase activity
NPD12_1660	COG1136	(ABC) transporter
NPD12_1664	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NPD12_1667	COG1126	abc transporter atp-binding protein
NPD12_1669	COG1686	Belongs to the peptidase S11 family
NPD12_167	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NPD12_1670	COG0494	nUDIX hydrolase
NPD12_1672	COG1979	alcohol dehydrogenase
NPD12_1674	COG1288	antiporter activity
NPD12_1675	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NPD12_1676	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPD12_1681	COG0849	cell division
NPD12_1682	COG1473	amidohydrolase
NPD12_1683	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPD12_1684	COG0564	pseudouridine synthase activity
NPD12_1685	COG2244	polysaccharide biosynthetic process
NPD12_1690	COG1067	ATP-dependent peptidase activity
NPD12_1695	COG3227	Zinc metalloprotease (Elastase)
NPD12_1697	COG0157	Belongs to the NadC ModD family
NPD12_17	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NPD12_1701	COG1272	protein, Hemolysin III
NPD12_1702	COG0012	GTP binding
NPD12_1703	COG2001	Belongs to the MraZ family
NPD12_1706	COG0768	penicillin binding
NPD12_1708	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NPD12_1710	COG0772	Belongs to the SEDS family
NPD12_1713	COG3856	small basic protein
NPD12_1715	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NPD12_1719	COG3599	regulation of cell shape
NPD12_1721	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NPD12_1722	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NPD12_1722	COG1605	Chorismate mutase
NPD12_1724	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NPD12_1725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NPD12_1726	COG0564	pseudouridine synthase activity
NPD12_1727	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NPD12_1728	COG2233	PERMEase
NPD12_1729	COG0708	Exodeoxyribonuclease III
NPD12_173	COG2816	NAD+ diphosphatase activity
NPD12_1730	COG0116	Belongs to the methyltransferase superfamily
NPD12_1732	COG0725	ABC transporter, periplasmic molybdate-binding protein
NPD12_1733	COG4149	molybdate abc transporter
NPD12_1734	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NPD12_1736	COG1752	Esterase of the alpha-beta hydrolase superfamily
NPD12_1738	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NPD12_1739	COG1757	Na H antiporter
NPD12_1741	COG0523	cobalamin synthesis protein
NPD12_1743	COG5012	cobalamin binding
NPD12_1744	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NPD12_1746	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NPD12_1747	COG2011	ABC-type metal ion transport system permease component
NPD12_1748	COG1464	Belongs to the NlpA lipoprotein family
NPD12_1750	COG0446	pyridine nucleotide-disulphide oxidoreductase
NPD12_1750	COG1902	pentaerythritol trinitrate reductase activity
NPD12_1752	COG0723	plastoquinol--plastocyanin reductase activity
NPD12_1752	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NPD12_1754	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NPD12_1755	COG0667	Aldo Keto reductase
NPD12_1756	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
NPD12_1758	COG3842	ATPase activity
NPD12_1760	COG0395	ABC-type sugar transport system, permease component
NPD12_1762	COG0039	L-malate dehydrogenase activity
NPD12_1763	COG2186	Transcriptional regulator
NPD12_1768	COG0840	transmembrane signaling receptor activity
NPD12_177	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NPD12_1771	COG1733	regulation of RNA biosynthetic process
NPD12_1773	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NPD12_1774	COG5564	TIM-barrel signal transduction protein
NPD12_1776	COG5564	TIM-barrel signal transduction protein
NPD12_1779	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NPD12_1783	COG1639	'signal transduction protein
NPD12_1784	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NPD12_1789	COG2197	response regulator
NPD12_179	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPD12_1791	COG2378	regulation of single-species biofilm formation
NPD12_1793	COG1924	4 iron, 4 sulfur cluster binding
NPD12_1794	COG0720	synthase
NPD12_1795	COG0602	queuosine metabolic process
NPD12_1796	COG0302	gtp cyclohydrolase
NPD12_18	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NPD12_1802	COG2390	Transcriptional regulator
NPD12_1803	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NPD12_1804	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPD12_1805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NPD12_1807	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NPD12_1808	COG0131	Imidazoleglycerol-phosphate dehydratase
NPD12_1809	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NPD12_1810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NPD12_1811	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NPD12_1813	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NPD12_1814	COG0140	phosphoribosyl-ATP diphosphatase activity
NPD12_1815	COG2391	methyltransferase activity
NPD12_1817	COG2391	methyltransferase activity
NPD12_1818	COG0583	DNA-binding transcription factor activity
NPD12_1820	COG0446	pyridine nucleotide-disulphide oxidoreductase
NPD12_1821	COG2391	methyltransferase activity
NPD12_1827	COG2235	arginine
NPD12_1832	COG3344	reverse transcriptase
NPD12_1840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPD12_1840	COG2207	Transcriptional regulator
NPD12_1841	COG1132	(ABC) transporter
NPD12_1842	COG1132	(ABC) transporter
NPD12_1843	COG1609	Transcriptional regulator
NPD12_1844	COG1940	carbohydrate kinase activity
NPD12_1845	COG0366	Alpha amylase catalytic
NPD12_1846	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_1846	COG2190	(PTS) system
NPD12_1846	COG1263	PTS System
NPD12_1849	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NPD12_1852	COG2205	protein histidine kinase activity
NPD12_1855	COG0561	phosphatase activity
NPD12_1856	COG1349	DNA-binding transcription factor activity
NPD12_1861	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NPD12_1863	COG1410	methionine synthase
NPD12_1863	COG0646	methionine synthase
NPD12_1869	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPD12_1870	COG0022	dehydrogenase e1 component
NPD12_1871	COG3199	ATP-NAD kinase
NPD12_1872	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPD12_1873	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPD12_1874	COG0095	Lipoate-protein ligase
NPD12_1875	COG0517	IMP dehydrogenase activity
NPD12_1875	COG1125	glycine betaine transport
NPD12_1877	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NPD12_1879	COG0527	aspartate kinase activity
NPD12_1880	COG0460	homoserine dehydrogenase
NPD12_1884	COG0493	'glutamate synthase
NPD12_1884	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NPD12_1887	COG5492	domain, Protein
NPD12_1899	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NPD12_1900	COG0840	transmembrane signaling receptor activity
NPD12_1903	COG1028	Short-chain dehydrogenase reductase Sdr
NPD12_1904	COG0840	transmembrane signaling receptor activity
NPD12_1907	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NPD12_1911	COG0601	transmembrane transport
NPD12_1914	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NPD12_1914	COG1199	ATP-dependent helicase activity
NPD12_1915	COG4086	secreted protein
NPD12_1917	COG1105	Belongs to the carbohydrate kinase PfkB family
NPD12_1918	COG3104	oligopeptide transport
NPD12_1923	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPD12_1924	COG2340	Cysteine-rich secretory protein family
NPD12_1926	COG0840	transmembrane signaling receptor activity
NPD12_1927	COG0488	(ABC) transporter
NPD12_1928	COG2221	Nitrite and sulphite reductase 4Fe-4S
NPD12_1929	COG0784	Response regulator, receiver
NPD12_1929	COG0835	chemotaxis
NPD12_1931	COG2996	Protein conserved in bacteria
NPD12_1935	COG1705	Flagellar rod assembly protein muramidase FlgJ
NPD12_1936	COG1528	Iron-storage protein
NPD12_1937	COG2201	protein-glutamate methylesterase activity
NPD12_1943	COG4974	Belongs to the 'phage' integrase family
NPD12_1946	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NPD12_1948	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NPD12_1949	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NPD12_1950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NPD12_1952	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_1954	COG0436	Aminotransferase
NPD12_1960	COG2081	HI0933 family
NPD12_1962	COG1737	Transcriptional regulator
NPD12_1963	COG1187	pseudouridine synthase activity
NPD12_1966	COG1215	transferase activity, transferring glycosyl groups
NPD12_1968	COG0840	transmembrane signaling receptor activity
NPD12_1969	COG4232	protein-disulfide reductase activity
NPD12_1971	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NPD12_1973	COG0475	glutathione-regulated potassium exporter activity
NPD12_1973	COG0569	domain protein
NPD12_1974	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NPD12_1977	COG0393	Putative heavy-metal-binding
NPD12_1979	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NPD12_1983	COG0309	Hydrogenase expression formation protein (HypE)
NPD12_1984	COG0409	Hydrogenase expression formation protein
NPD12_1985	COG0298	carbon dioxide binding
NPD12_1986	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
NPD12_1993	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NPD12_1999	COG0488	(ABC) transporter
NPD12_200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NPD12_2003	COG0589	response to stress
NPD12_2003	COG0475	glutathione-regulated potassium exporter activity
NPD12_2005	COG0628	permease
NPD12_2006	COG1686	Belongs to the peptidase S11 family
NPD12_2008	COG3874	Sporulation protein YtfJ
NPD12_2009	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NPD12_2010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NPD12_2012	COG1686	Belongs to the peptidase S11 family
NPD12_2016	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NPD12_2017	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NPD12_2018	COG4974	Belongs to the 'phage' integrase family
NPD12_2022	COG0531	amino acid
NPD12_2038	COG0745	RESPONSE REGULATOR receiver
NPD12_2039	COG0750	zinc metalloprotease
NPD12_204	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NPD12_2040	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NPD12_2041	COG0460	homoserine dehydrogenase
NPD12_2043	COG0497	DNA recombination
NPD12_2045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NPD12_2046	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NPD12_2050	COG1722	exodeoxyribonuclease VII activity
NPD12_206	COG1619	proteins homologs of microcin C7 resistance protein MccF
NPD12_2061	COG3854	ATPases associated with a variety of cellular activities
NPD12_2064	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NPD12_2073	COG2165	general secretion pathway protein
NPD12_2075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NPD12_2082	COG0076	glutamate decarboxylase activity
NPD12_2084	COG5278	phosphoserine phosphatase activity
NPD12_2084	COG0840	transmembrane signaling receptor activity
NPD12_2088	COG5002	protein histidine kinase activity
NPD12_2091	COG5002	protein histidine kinase activity
NPD12_2095	COG1131	(ABC) transporter
NPD12_2096	COG1132	(ABC) transporter
NPD12_2099	COG0456	acetyltransferase
NPD12_2102	COG2414	aldehyde ferredoxin oxidoreductase
NPD12_2105	COG0315	cyclic pyranopterin monophosphate synthase activity
NPD12_2107	COG1910	domain protein
NPD12_2108	COG0303	'Molybdopterin
NPD12_2109	COG0521	Mo-molybdopterin cofactor biosynthetic process
NPD12_211	COG1982	Orn Lys Arg decarboxylase major
NPD12_2113	COG0534	Mate efflux family protein
NPD12_2116	COG1136	(ABC) transporter
NPD12_2117	COG0577	efflux transmembrane transporter activity
NPD12_2119	COG2267	carboxylic ester hydrolase activity
NPD12_2120	COG1132	(ABC) transporter
NPD12_2122	COG4978	Transcriptional regulator
NPD12_2122	COG0789	Transcriptional regulator
NPD12_213	COG3870	Protein conserved in bacteria
NPD12_2130	COG5002	protein histidine kinase activity
NPD12_2131	COG0745	RESPONSE REGULATOR receiver
NPD12_2133	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NPD12_2134	COG4172	Belongs to the ABC transporter superfamily
NPD12_2135	COG4721	ABC-type cobalt transport system, permease component
NPD12_2136	COG3457	Alanine racemase
NPD12_2138	COG0697	spore germination
NPD12_2139	COG0814	amino acid
NPD12_214	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NPD12_2146	COG3263	regulation of cellular component size
NPD12_2147	COG0326	Molecular chaperone. Has ATPase activity
NPD12_2148	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NPD12_2149	COG1263	PTS System
NPD12_2149	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_215	COG1774	PSP1 C-terminal conserved region
NPD12_2150	COG0366	Alpha amylase catalytic
NPD12_2151	COG2188	Transcriptional regulator
NPD12_2152	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPD12_2152	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPD12_2152	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPD12_2153	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPD12_2153	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPD12_2153	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPD12_2154	COG1105	Belongs to the carbohydrate kinase PfkB family
NPD12_2161	COG0840	transmembrane signaling receptor activity
NPD12_2162	COG3457	Alanine racemase
NPD12_2164	COG0673	inositol 2-dehydrogenase activity
NPD12_2165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NPD12_2167	COG3706	GGDEF domain
NPD12_2171	COG2340	Cysteine-rich secretory protein family
NPD12_2172	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_2173	COG0697	spore germination
NPD12_2175	COG1126	abc transporter atp-binding protein
NPD12_2176	COG0765	amino acid transport
NPD12_2177	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPD12_2178	COG3875	lactate racemase activity
NPD12_2179	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NPD12_218	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NPD12_2187	COG3104	oligopeptide transport
NPD12_2188	COG3104	oligopeptide transport
NPD12_2189	COG0006	proline dipeptidase activity
NPD12_219	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NPD12_2191	COG0733	neurotransmitter:sodium symporter activity
NPD12_2195	COG2304	oxidoreductase activity
NPD12_2197	COG0714	Associated with various cellular activities
NPD12_2198	COG4716	Myosin-crossreactive antigen
NPD12_22	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NPD12_220	COG0791	NLP P60 protein
NPD12_2202	COG0840	transmembrane signaling receptor activity
NPD12_2206	COG1045	serine acetyltransferase
NPD12_221	COG2002	toxin-antitoxin pair type II binding
NPD12_2216	COG0402	S-adenosylhomocysteine deaminase activity
NPD12_2217	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NPD12_2225	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NPD12_2230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPD12_2231	COG1215	transferase activity, transferring glycosyl groups
NPD12_2232	COG1216	Glycosyl transferase, family 2
NPD12_224	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NPD12_2240	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NPD12_2241	COG4869	propanediol catabolic process
NPD12_2242	COG1012	belongs to the aldehyde dehydrogenase family
NPD12_2242	COG1454	alcohol dehydrogenase
NPD12_2243	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NPD12_2247	COG4820	ethanolamine utilization protein (EutJ)
NPD12_225	COG0726	polysaccharide deacetylase
NPD12_2250	COG4810	utilization protein
NPD12_2251	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NPD12_2252	COG1882	Formate acetyltransferase
NPD12_2253	COG1454	alcohol dehydrogenase
NPD12_2253	COG1012	belongs to the aldehyde dehydrogenase family
NPD12_2254	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NPD12_2255	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NPD12_2258	COG0789	Transcriptional regulator
NPD12_2261	COG2807	transmembrane transport
NPD12_2262	COG2186	Transcriptional regulator
NPD12_2266	COG3878	Protein conserved in bacteria
NPD12_2269	COG3764	Sortase (surface protein transpeptidase)
NPD12_227	COG2715	membrane protein required for spore maturation
NPD12_2272	COG0745	RESPONSE REGULATOR receiver
NPD12_2275	COG4555	ABC transporter
NPD12_2276	COG0577	efflux transmembrane transporter activity
NPD12_2278	COG3655	Transcriptional regulator
NPD12_228	COG0700	Nucleoside recognition
NPD12_2280	COG1063	alcohol dehydrogenase
NPD12_2283	COG0577	efflux transmembrane transporter activity
NPD12_2284	COG1136	(ABC) transporter
NPD12_2286	COG3711	transcriptional antiterminator
NPD12_2286	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPD12_2289	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPD12_229	COG0534	Mate efflux family protein
NPD12_2290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NPD12_2293	COG0110	maltose O-acetyltransferase activity
NPD12_2295	COG3104	oligopeptide transport
NPD12_2296	COG2226	methyltransferase
NPD12_2297	COG3708	Transcriptional regulator
NPD12_2297	COG2207	Transcriptional regulator
NPD12_230	COG1573	uracil-dna glycosylase
NPD12_2301	COG0384	phenazine biosynthesis protein PhzF
NPD12_2302	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_2306	COG1396	sequence-specific DNA binding
NPD12_2309	COG0531	amino acid
NPD12_2314	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NPD12_2315	COG2086	electron transfer activity
NPD12_2316	COG1960	acyl-CoA dehydrogenase activity
NPD12_232	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPD12_232	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPD12_2323	COG0840	transmembrane signaling receptor activity
NPD12_2326	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NPD12_2328	COG0346	lactoylglutathione lyase activity
NPD12_2329	COG2610	gluconate transmembrane transporter activity
NPD12_233	COG4399	Belongs to the UPF0754 family
NPD12_2331	COG3395	kinase activity
NPD12_2332	COG1349	DNA-binding transcription factor activity
NPD12_2339	COG5599	Phosphatase
NPD12_234	COG0084	hydrolase, TatD family'
NPD12_2340	COG1063	alcohol dehydrogenase
NPD12_2341	COG1151	hydroxylamine reductase activity
NPD12_2342	COG0375	protein maturation
NPD12_2343	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NPD12_2346	COG0489	protein tyrosine kinase activity
NPD12_2349	COG1360	Flagellar Motor Protein
NPD12_235	COG3584	3D domain protein
NPD12_235	COG3583	domain protein
NPD12_2350	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NPD12_2351	COG2247	cell wall binding repeat
NPD12_2351	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPD12_2354	COG1297	OPT oligopeptide transporter protein
NPD12_2355	COG2195	Cleaves the N-terminal amino acid of tripeptides
NPD12_2357	COG1929	Belongs to the glycerate kinase type-1 family
NPD12_2359	COG1028	Short-chain dehydrogenase reductase Sdr
NPD12_2360	COG1668	transmembrane transport
NPD12_2361	COG4555	ABC transporter
NPD12_2362	COG2153	protein acetylation
NPD12_2363	COG1846	Transcriptional regulator
NPD12_2365	COG2205	protein histidine kinase activity
NPD12_2368	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NPD12_2370	COG0531	amino acid
NPD12_2375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NPD12_2378	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPD12_2380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NPD12_2382	COG1268	BioY protein
NPD12_2384	COG0006	proline dipeptidase activity
NPD12_2385	COG3104	oligopeptide transport
NPD12_24	COG2045	Belongs to the ComB family
NPD12_2400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NPD12_2401	COG1132	(ABC) transporter
NPD12_2402	COG1132	(ABC) transporter
NPD12_2407	COG2205	protein histidine kinase activity
NPD12_2408	COG0745	RESPONSE REGULATOR receiver
NPD12_2412	COG0242	peptide deformylase activity
NPD12_2416	COG3344	reverse transcriptase
NPD12_2417	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NPD12_242	COG1136	(ABC) transporter
NPD12_243	COG0577	efflux transmembrane transporter activity
NPD12_2430	COG3344	reverse transcriptase
NPD12_2437	COG3850	Histidine kinase
NPD12_2437	COG5002	protein histidine kinase activity
NPD12_2438	COG0745	RESPONSE REGULATOR receiver
NPD12_2441	COG1484	DNA-dependent DNA replication
NPD12_2442	COG0445	tRNA wobble uridine modification
NPD12_2444	COG2155	Conserved Protein
NPD12_2445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPD12_2446	COG0436	Aminotransferase
NPD12_2447	COG2076	Multidrug Resistance protein
NPD12_2449	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NPD12_245	COG1141	Ferredoxin
NPD12_2450	COG2359	stage V sporulation protein S
NPD12_2453	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NPD12_2455	COG1674	ftsk spoiiie
NPD12_2456	COG0740	serine-type endopeptidase activity
NPD12_2457	COG0527	aspartate kinase activity
NPD12_2459	COG0612	Peptidase, M16
NPD12_2460	COG1185	polyribonucleotide nucleotidyltransferase activity
NPD12_2462	COG0196	riboflavin kinase activity
NPD12_2464	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NPD12_2467	COG1358	cellular component organization or biogenesis
NPD12_2468	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NPD12_2469	COG0195	Participates in both transcription termination and antitermination
NPD12_247	COG3706	GGDEF domain
NPD12_2472	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NPD12_2473	COG0750	zinc metalloprotease
NPD12_2474	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NPD12_2478	COG4589	Belongs to the CDS family
NPD12_248	COG1285	pathogenesis
NPD12_2485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NPD12_2486	COG0758	DNA mediated transformation
NPD12_249	COG1328	CTP reductase activity
NPD12_2490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NPD12_2491	COG0681	Belongs to the peptidase S26 family
NPD12_2495	COG1837	Belongs to the UPF0109 family
NPD12_2497	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NPD12_2499	COG0552	protein localization to endoplasmic reticulum
NPD12_25	COG1242	4 iron, 4 sulfur cluster binding
NPD12_2504	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPD12_2506	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NPD12_2507	COG1399	metal-binding, possibly nucleic acid-binding protein
NPD12_2508	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NPD12_2509	COG0280	phosphate acetyltransferase
NPD12_2511	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPD12_2512	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPD12_2514	COG5275	peptidyl-tyrosine sulfation
NPD12_2514	COG0252	asparaginase activity
NPD12_2517	COG0840	transmembrane signaling receptor activity
NPD12_2520	COG0531	amino acid
NPD12_2524	COG5275	peptidyl-tyrosine sulfation
NPD12_2524	COG0252	asparaginase activity
NPD12_2526	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPD12_2527	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPD12_2529	COG0252	asparaginase activity
NPD12_2529	COG5275	peptidyl-tyrosine sulfation
NPD12_253	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NPD12_2530	COG4656	Part of a membrane complex involved in electron transport
NPD12_2531	COG5275	peptidyl-tyrosine sulfation
NPD12_2531	COG0252	asparaginase activity
NPD12_2532	COG4656	Part of a membrane complex involved in electron transport
NPD12_2535	COG5275	peptidyl-tyrosine sulfation
NPD12_2535	COG0252	asparaginase activity
NPD12_2536	COG4656	Part of a membrane complex involved in electron transport
NPD12_2537	COG3829	transcription factor binding
NPD12_2537	COG3290	protein histidine kinase activity
NPD12_254	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NPD12_2542	COG0742	ribosomal rna small subunit methyltransferase
NPD12_2543	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NPD12_2544	COG1461	Dihydroxyacetone kinase
NPD12_2545	COG1302	Protein conserved in bacteria
NPD12_2549	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NPD12_2550	COG1162	GTPase activity
NPD12_2551	COG0515	serine threonine protein kinase
NPD12_2551	COG2815	serine threonine protein kinase
NPD12_2552	COG0631	protein serine/threonine phosphatase activity
NPD12_2554	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NPD12_2554	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NPD12_2555	COG2738	Putative neutral zinc metallopeptidase
NPD12_2557	COG0242	peptide deformylase activity
NPD12_2558	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NPD12_2559	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NPD12_256	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
NPD12_2561	COG0194	GDP metabolic process
NPD12_2563	COG1561	YicC-like family, N-terminal region
NPD12_2567	COG1160	GTP binding
NPD12_2569	COG0704	Plays a role in the regulation of phosphate uptake
NPD12_257	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
NPD12_257	COG0662	Cupin 2, conserved barrel domain protein
NPD12_2570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NPD12_2571	COG0581	inorganic phosphate transmembrane transporter activity
NPD12_2572	COG0573	inorganic phosphate transmembrane transporter activity
NPD12_2573	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NPD12_2574	COG5002	protein histidine kinase activity
NPD12_2575	COG0745	RESPONSE REGULATOR receiver
NPD12_2578	COG1873	PFAM PRC-barrel domain
NPD12_2579	COG1191	sigma factor activity
NPD12_258	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NPD12_2580	COG1191	sigma factor activity
NPD12_2582	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NPD12_2583	COG0849	cell division
NPD12_2584	COG1215	transferase activity, transferring glycosyl groups
NPD12_2588	COG1191	sigma factor activity
NPD12_259	COG1606	tRNA processing
NPD12_2593	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NPD12_2599	COG0768	penicillin binding
NPD12_260	COG1691	(AIR) carboxylase
NPD12_2603	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NPD12_2605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NPD12_2606	COG0735	belongs to the Fur family
NPD12_2611	COG0628	permease
NPD12_2613	COG0822	iron-sulfur transferase activity
NPD12_2615	COG1959	2 iron, 2 sulfur cluster binding
NPD12_2616	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NPD12_2617	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NPD12_262	COG1653	transport
NPD12_2622	COG1115	amino acid carrier protein
NPD12_2623	COG1115	amino acid carrier protein
NPD12_2626	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NPD12_2628	COG0574	Belongs to the PEP-utilizing enzyme family
NPD12_2628	COG3848	Pyruvate phosphate dikinase
NPD12_2631	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPD12_264	COG3642	lipopolysaccharide core region biosynthetic process
NPD12_2642	COG2966	Psort location CytoplasmicMembrane, score
NPD12_2644	COG1937	Protein conserved in bacteria
NPD12_2645	COG0561	phosphatase activity
NPD12_2647	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NPD12_2648	COG0039	L-malate dehydrogenase activity
NPD12_2650	COG0613	PHP domain protein
NPD12_2651	COG1362	aminopeptidase activity
NPD12_2652	COG0598	Magnesium transport protein CorA
NPD12_2653	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NPD12_2655	COG4224	UPF0291 protein
NPD12_2656	COG0398	Pfam SNARE associated Golgi protein
NPD12_2657	COG0398	Pfam SNARE associated Golgi protein
NPD12_2661	COG0463	Glycosyl transferase, family 2
NPD12_2662	COG2897	thiosulfate sulfurtransferase activity
NPD12_2663	COG1494	fructose-1,6-bisphosphatase
NPD12_2665	COG0426	domain, Protein
NPD12_2672	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
NPD12_2676	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
NPD12_2677	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NPD12_2678	COG1269	ATP hydrolysis coupled proton transport
NPD12_2684	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NPD12_2688	COG4786	Flagellar basal body rod
NPD12_2691	COG1191	sigma factor activity
NPD12_2693	COG0455	bacterial-type flagellum organization
NPD12_2694	COG1419	protein localization to endoplasmic reticulum
NPD12_2695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NPD12_2696	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NPD12_2698	COG1338	Plays a role in the flagellum-specific transport system
NPD12_27	COG3949	Membrane
NPD12_2703	COG1582	Flagellar protein (FlbD)
NPD12_2704	COG4786	Flagellar basal body rod
NPD12_2706	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NPD12_2709	COG1157	protein secretion by the type III secretion system
NPD12_271	COG4466	Protein conserved in bacteria
NPD12_2711	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPD12_2712	COG1766	The M ring may be actively involved in energy transduction
NPD12_2713	COG1677	Flagellar hook-basal body complex protein FliE
NPD12_2714	COG1558	bacterial-type flagellum-dependent cell motility
NPD12_2715	COG1815	bacterial-type flagellum-dependent cell motility
NPD12_2716	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPD12_2722	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPD12_2723	COG4129	membrane
NPD12_2728	COG2089	acid synthase
NPD12_2729	COG1083	cytidylyl-transferase
NPD12_273	COG4242	Belongs to the peptidase S51 family
NPD12_2733	COG0562	UDP-galactopyranose mutase
NPD12_2735	COG0489	protein tyrosine kinase activity
NPD12_2736	COG4464	protein tyrosine phosphatase activity
NPD12_2737	COG3944	biosynthesis protein
NPD12_274	COG0189	ligase activity
NPD12_274	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NPD12_2742	COG0840	transmembrane signaling receptor activity
NPD12_2743	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPD12_2752	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPD12_2753	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPD12_2754	COG0110	maltose O-acetyltransferase activity
NPD12_2757	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NPD12_2758	COG2089	acid synthase
NPD12_2760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NPD12_2761	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NPD12_2763	COG2604	Protein of unknown function DUF115
NPD12_2764	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPD12_2766	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NPD12_2767	COG1516	flagellar protein fliS
NPD12_277	COG0697	spore germination
NPD12_2773	COG1256	bacterial-type flagellum assembly
NPD12_2773	COG4786	Flagellar basal body rod
NPD12_2776	COG1776	CheC inhibitor of MCP methylation
NPD12_2776	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPD12_2777	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPD12_2778	COG0835	chemotaxis
NPD12_2779	COG2201	protein-glutamate methylesterase activity
NPD12_278	COG0531	amino acid
NPD12_2780	COG1776	CheC inhibitor of MCP methylation
NPD12_2781	COG0643	Histidine kinase
NPD12_2781	COG2198	Histidine kinase
NPD12_2782	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NPD12_2783	COG2201	protein-glutamate methylesterase activity
NPD12_2787	COG1263	PTS System
NPD12_2787	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_2787	COG2190	(PTS) system
NPD12_2788	COG3711	transcriptional antiterminator
NPD12_2796	COG5002	protein histidine kinase activity
NPD12_2797	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NPD12_2797	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NPD12_2803	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NPD12_2804	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NPD12_2805	COG0187	DNA topoisomerase II activity
NPD12_281	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NPD12_2812	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NPD12_2815	COG2207	Transcriptional regulator
NPD12_2816	COG1619	proteins homologs of microcin C7 resistance protein MccF
NPD12_2817	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NPD12_2818	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NPD12_282	COG2959	enzyme of heme biosynthesis
NPD12_2822	COG1131	(ABC) transporter
NPD12_2823	COG1725	Transcriptional regulator
NPD12_2825	COG1151	hydroxylamine reductase activity
NPD12_2829	COG0814	amino acid
NPD12_2830	COG0697	spore germination
NPD12_2833	COG0513	Belongs to the DEAD box helicase family
NPD12_2836	COG3290	protein histidine kinase activity
NPD12_2836	COG0840	transmembrane signaling receptor activity
NPD12_2839	COG2066	Belongs to the glutaminase family
NPD12_2840	COG1388	LysM domain
NPD12_2840	COG3584	3D domain protein
NPD12_2841	COG0840	transmembrane signaling receptor activity
NPD12_2843	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NPD12_2844	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NPD12_2847	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NPD12_2849	COG0493	'glutamate synthase
NPD12_2850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NPD12_2854	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NPD12_2856	COG0840	transmembrane signaling receptor activity
NPD12_2858	COG0735	belongs to the Fur family
NPD12_286	COG0504	CTP synthase activity
NPD12_2862	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NPD12_2864	COG3711	transcriptional antiterminator
NPD12_2865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_2865	COG1263	PTS System
NPD12_2865	COG2190	(PTS) system
NPD12_2866	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_2866	COG1263	PTS System
NPD12_2867	COG0534	Mate efflux family protein
NPD12_2868	COG0719	Fe-S assembly protein
NPD12_2869	COG3842	ATPase activity
NPD12_2871	COG0735	belongs to the Fur family
NPD12_2873	COG0426	domain, Protein
NPD12_2874	COG1960	acyl-CoA dehydrogenase activity
NPD12_2875	COG2801	Transposase and inactivated derivatives
NPD12_2879	COG3715	PTS system
NPD12_288	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NPD12_2880	COG3716	PTS system mannose fructose sorbose family IID component
NPD12_2882	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NPD12_2884	COG2068	MobA-Related Protein
NPD12_2885	COG2080	2 iron, 2 sulfur cluster binding
NPD12_2887	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NPD12_2888	COG2723	6-phospho-beta-galactosidase activity
NPD12_2889	COG2723	6-phospho-beta-galactosidase activity
NPD12_2890	COG0475	glutathione-regulated potassium exporter activity
NPD12_2898	COG0488	(ABC) transporter
NPD12_29	COG0840	transmembrane signaling receptor activity
NPD12_291	COG3872	metal-dependent enzyme
NPD12_2911	COG0535	radical SAM domain protein
NPD12_2913	COG1132	(ABC) transporter
NPD12_2916	COG1368	sulfuric ester hydrolase activity
NPD12_2917	COG0730	response to heat
NPD12_2919	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPD12_2919	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPD12_2922	COG2195	Cleaves the N-terminal amino acid of tripeptides
NPD12_2923	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPD12_2926	COG0151	Belongs to the GarS family
NPD12_2928	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NPD12_293	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NPD12_2930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NPD12_2932	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NPD12_2934	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPD12_2935	COG0402	S-adenosylhomocysteine deaminase activity
NPD12_2936	COG0493	'glutamate synthase
NPD12_2936	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NPD12_2937	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NPD12_2939	COG2233	PERMEase
NPD12_2942	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NPD12_2944	COG3608	succinylglutamate desuccinylase aspartoacylase
NPD12_2944	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NPD12_2948	COG1120	ATPase activity
NPD12_2954	COG2252	PERMEase
NPD12_2955	COG1115	amino acid carrier protein
NPD12_2956	COG3973	AAA domain
NPD12_2959	COG4187	Peptidase family M20/M25/M40
NPD12_296	COG0009	L-threonylcarbamoyladenylate synthase
NPD12_2960	COG1956	GAF domain-containing protein
NPD12_2961	COG1253	flavin adenine dinucleotide binding
NPD12_2964	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NPD12_2969	COG1725	Transcriptional regulator
NPD12_297	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPD12_2972	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NPD12_2973	COG3773	Cell wall hydrolase
NPD12_2977	COG0584	glycerophosphoryl diester phosphodiesterase
NPD12_298	COG0698	ribose 5-phosphate isomerase
NPD12_2980	COG1253	flavin adenine dinucleotide binding
NPD12_2983	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NPD12_2986	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NPD12_2987	COG0358	DNA primase activity
NPD12_2990	COG0574	Belongs to the PEP-utilizing enzyme family
NPD12_2990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NPD12_2991	COG0517	IMP dehydrogenase activity
NPD12_2992	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NPD12_2993	COG1381	Involved in DNA repair and RecF pathway recombination
NPD12_2997	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NPD12_2998	COG1480	7TM receptor with intracellular HD hydrolase
NPD12_3	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NPD12_3001	COG1610	YqeY-like protein
NPD12_3003	COG0537	adenosine 5'-monophosphoramidase activity
NPD12_3004	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NPD12_3005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NPD12_3007	COG0484	heat shock protein binding
NPD12_3011	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NPD12_302	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NPD12_303	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NPD12_3033	COG3299	homolog of phage Mu protein gp47
NPD12_305	COG0356	it plays a direct role in the translocation of protons across the membrane
NPD12_3055	COG3728	DNA packaging
NPD12_3065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPD12_3065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPD12_3078	COG0582	viral genome integration into host DNA
NPD12_308	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NPD12_3082	COG0709	Synthesizes selenophosphate from selenide and ATP
NPD12_3085	COG1686	Belongs to the peptidase S11 family
NPD12_3086	COG0564	pseudouridine synthase activity
NPD12_3087	COG0251	oxidation-reduction process
NPD12_3088	COG1316	TRANSCRIPTIONal
NPD12_3089	COG1713	HD superfamily hydrolase involved in NAD metabolism
NPD12_3090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NPD12_3091	COG1534	Rna-binding protein
NPD12_3096	COG1530	ribonuclease E activity
NPD12_310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NPD12_3100	COG0739	heme binding
NPD12_3101	COG0772	Belongs to the SEDS family
NPD12_3103	COG2894	cell division
NPD12_3104	COG0850	regulation of cytokinetic process
NPD12_3108	COG1077	Cell shape determining protein MreB Mrl
NPD12_3118	COG0237	dephospho-CoA kinase activity
NPD12_3119	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPD12_3119	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPD12_3148	COG1484	DNA-dependent DNA replication
NPD12_315	COG2385	sporulation resulting in formation of a cellular spore
NPD12_3165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NPD12_3166	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPD12_3167	COG1490	D-aminoacyl-tRNA deacylase activity
NPD12_3168	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NPD12_317	COG1609	Transcriptional regulator
NPD12_3171	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NPD12_3172	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NPD12_3176	COG1862	Preprotein translocase
NPD12_3180	COG0632	four-way junction helicase activity
NPD12_3182	COG0217	transcriptional regulatory protein
NPD12_3183	COG1739	Uncharacterized protein family UPF0029
NPD12_3185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_3188	COG1773	rubredoxin
NPD12_3189	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NPD12_3194	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPD12_32	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NPD12_320	COG0037	tRNA processing
NPD12_3201	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NPD12_3204	COG0728	peptidoglycan biosynthetic process
NPD12_3206	COG0438	transferase activity, transferring glycosyl groups
NPD12_3210	COG0438	transferase activity, transferring glycosyl groups
NPD12_3214	COG2244	polysaccharide biosynthetic process
NPD12_3218	COG1086	Polysaccharide biosynthesis protein
NPD12_3221	COG4193	domain, Protein
NPD12_3222	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NPD12_3224	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NPD12_3225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NPD12_3226	COG1982	Orn Lys Arg decarboxylase major
NPD12_3228	COG0280	phosphate acetyltransferase
NPD12_3230	COG1683	Conserved Protein
NPD12_3231	COG1193	negative regulation of DNA recombination
NPD12_3232	COG0826	peptidase U32
NPD12_3236	COG0463	Glycosyl transferase, family 2
NPD12_3236	COG0457	Tetratricopeptide repeat
NPD12_3240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NPD12_3241	COG0569	domain protein
NPD12_3242	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NPD12_3250	COG1131	(ABC) transporter
NPD12_3257	COG2226	methyltransferase
NPD12_3259	COG4608	Belongs to the ABC transporter superfamily
NPD12_326	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NPD12_3260	COG0444	Belongs to the ABC transporter superfamily
NPD12_3261	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPD12_3262	COG0601	transmembrane transport
NPD12_3264	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NPD12_3266	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NPD12_3267	COG0436	Aminotransferase
NPD12_327	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NPD12_3277	COG0456	acetyltransferase
NPD12_3278	COG1136	(ABC) transporter
NPD12_3280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NPD12_3282	COG1116	anion transmembrane transporter activity
NPD12_3283	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NPD12_3287	COG0612	Peptidase, M16
NPD12_3292	COG3123	guanosine phosphorylase activity
NPD12_3293	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPD12_3296	COG1396	sequence-specific DNA binding
NPD12_3300	COG0714	Associated with various cellular activities
NPD12_3306	COG1924	4 iron, 4 sulfur cluster binding
NPD12_3308	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NPD12_3309	COG2086	electron transfer activity
NPD12_3310	COG1960	acyl-CoA dehydrogenase activity
NPD12_3311	COG0183	Belongs to the thiolase family
NPD12_3312	COG1250	3-hydroxyacyl-CoA dehydrogenase
NPD12_3313	COG1024	Enoyl-CoA hydratase
NPD12_3316	COG2252	PERMEase
NPD12_3322	COG0584	glycerophosphoryl diester phosphodiesterase
NPD12_3323	COG0840	transmembrane signaling receptor activity
NPD12_3324	COG1773	rubredoxin
NPD12_3324	COG1592	Rubrerythrin
NPD12_3331	COG0735	belongs to the Fur family
NPD12_3334	COG2378	regulation of single-species biofilm formation
NPD12_3338	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NPD12_3339	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NPD12_334	COG2183	response to ionizing radiation
NPD12_3340	COG1067	ATP-dependent peptidase activity
NPD12_3340	COG0470	DNA polymerase III
NPD12_3343	COG0544	peptidyl-prolyl cis-trans isomerase activity
NPD12_3344	COG1082	Xylose isomerase domain protein TIM barrel
NPD12_3346	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NPD12_3347	COG0167	dihydroorotate dehydrogenase activity
NPD12_3348	COG0543	2 iron, 2 sulfur cluster binding
NPD12_335	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NPD12_3353	COG1924	4 iron, 4 sulfur cluster binding
NPD12_3355	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NPD12_3356	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
NPD12_3359	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NPD12_3390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NPD12_3393	COG0747	negative chemotaxis
NPD12_3394	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NPD12_3395	COG0154	amidase activity
NPD12_3399	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NPD12_34	COG0174	glutamine synthetase
NPD12_340	COG0446	pyridine nucleotide-disulphide oxidoreductase
NPD12_3400	COG0210	DNA helicase
NPD12_3401	COG4496	protein, YerC YecD
NPD12_3402	COG1187	pseudouridine synthase activity
NPD12_3403	COG0741	lytic transglycosylase activity
NPD12_3406	COG1671	Belongs to the UPF0178 family
NPD12_3409	COG1309	transcriptional regulator
NPD12_3411	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPD12_3414	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NPD12_3415	COG2086	electron transfer activity
NPD12_3416	COG1960	acyl-CoA dehydrogenase activity
NPD12_342	COG2357	RelA SpoT domain protein
NPD12_3421	COG0318	PFAM AMP-dependent synthetase and ligase
NPD12_3422	COG1114	Component of the transport system for branched-chain amino acids
NPD12_3424	COG0517	IMP dehydrogenase activity
NPD12_3424	COG0516	GMP reductase activity
NPD12_3428	COG0398	Pfam SNARE associated Golgi protein
NPD12_3435	COG0488	(ABC) transporter
NPD12_3436	COG3279	Response regulator of the LytR AlgR family
NPD12_3437	COG3275	phosphorelay sensor kinase activity
NPD12_3438	COG1966	Carbon starvation protein
NPD12_344	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NPD12_3440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NPD12_3443	COG0446	pyridine nucleotide-disulphide oxidoreductase
NPD12_3448	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NPD12_3449	COG0802	atpase or kinase
NPD12_3450	COG1214	PFAM Peptidase M22, glycoprotease
NPD12_3451	COG0456	acetyltransferase
NPD12_3452	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NPD12_3458	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NPD12_3459	COG0561	phosphatase activity
NPD12_3461	COG2033	superoxide reductase activity
NPD12_347	COG0484	heat shock protein binding
NPD12_3470	COG1131	(ABC) transporter
NPD12_3475	COG1132	(ABC) transporter
NPD12_3476	COG3459	Glycosyltransferase 36 associated
NPD12_3479	COG1362	aminopeptidase activity
NPD12_3480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NPD12_3482	COG3973	AAA domain
NPD12_3483	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NPD12_3484	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPD12_3485	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NPD12_3486	COG2827	Endonuclease containing a URI domain
NPD12_3489	COG1131	(ABC) transporter
NPD12_3491	COG1595	DNA-templated transcription, initiation
NPD12_3492	COG0659	secondary active sulfate transmembrane transporter activity
NPD12_3496	COG1131	(ABC) transporter
NPD12_3500	COG2971	BadF BadG BcrA BcrD
NPD12_3501	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPD12_3503	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NPD12_3503	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NPD12_3504	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPD12_3505	COG1486	melibiose metabolic process
NPD12_3506	COG3706	GGDEF domain
NPD12_3506	COG2203	Gaf domain
NPD12_3506	COG5001	Diguanylate cyclase
NPD12_3506	COG4251	negative regulation of phosphorylation
NPD12_3507	COG4974	Belongs to the 'phage' integrase family
NPD12_351	COG0191	fructose-bisphosphate aldolase activity
NPD12_3510	COG5566	PFAM Mor transcription activator
NPD12_3511	COG1733	regulation of RNA biosynthetic process
NPD12_3514	COG0656	L-ascorbic acid biosynthetic process
NPD12_3516	COG0789	Transcriptional regulator
NPD12_3517	COG0295	cytidine deaminase activity
NPD12_3519	COG3708	Transcriptional regulator
NPD12_3519	COG2207	Transcriptional regulator
NPD12_3520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NPD12_3522	COG1959	2 iron, 2 sulfur cluster binding
NPD12_3523	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NPD12_3527	COG0469	pyruvate kinase activity
NPD12_353	COG2323	membrane
NPD12_3531	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NPD12_3533	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NPD12_3535	COG0322	excinuclease ABC activity
NPD12_3536	COG1988	membrane-bound metal-dependent
NPD12_3538	COG0768	penicillin binding
NPD12_354	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NPD12_3540	COG1716	ATPase activity
NPD12_3543	COG0750	zinc metalloprotease
NPD12_3544	COG3409	Peptidoglycan-binding domain 1 protein
NPD12_3544	COG0793	Belongs to the peptidase S41A family
NPD12_3545	COG2177	Part of the ABC transporter FtsEX involved in
NPD12_3546	COG2884	Cell division ATP-binding protein ftsE
NPD12_3547	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPD12_3549	COG3958	Transketolase
NPD12_3550	COG3959	Transketolase, thiamine diphosphate binding domain
NPD12_3553	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NPD12_3555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NPD12_3555	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NPD12_3556	COG0736	holo-[acyl-carrier-protein] synthase activity
NPD12_3559	COG1295	ribonuclease BN
NPD12_356	COG1183	phosphatidylcholine synthase activity
NPD12_3564	COG0789	Transcriptional regulator
NPD12_3567	COG2032	superoxide dismutase activity
NPD12_3568	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NPD12_3569	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NPD12_357	COG0517	IMP dehydrogenase activity
NPD12_3570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NPD12_3571	COG1028	Short-chain dehydrogenase reductase Sdr
NPD12_3573	COG3732	PTS system glucitol sorbitol-specific
NPD12_3576	COG1063	alcohol dehydrogenase
NPD12_358	COG1597	lipid kinase activity
NPD12_3581	COG0674	pyruvate-flavodoxin oxidoreductase activity
NPD12_3581	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NPD12_3585	COG0280	phosphate acetyltransferase
NPD12_3586	COG3426	butyrate kinase activity
NPD12_3587	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
NPD12_3589	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NPD12_3590	COG3773	Cell wall hydrolase
NPD12_3591	COG0492	ferredoxin-NADP+ reductase activity
NPD12_3592	COG3118	belongs to the thioredoxin family
NPD12_3593	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NPD12_3596	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NPD12_3597	COG3829	transcription factor binding
NPD12_3597	COG3290	protein histidine kinase activity
NPD12_360	COG1032	radical SAM domain protein
NPD12_3600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NPD12_3600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NPD12_3601	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPD12_3602	COG1283	sodium-dependent phosphate transmembrane transporter activity
NPD12_3605	COG0101	tRNA pseudouridine synthase activity
NPD12_3606	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NPD12_3608	COG1122	ATPase activity
NPD12_3612	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NPD12_3614	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NPD12_362	COG3773	Cell wall hydrolase
NPD12_362	COG3409	Peptidoglycan-binding domain 1 protein
NPD12_363	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPD12_364	COG1045	serine acetyltransferase
NPD12_3645	COG1358	cellular component organization or biogenesis
NPD12_3647	COG0085	RNA polymerase activity
NPD12_365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NPD12_3652	COG0250	Participates in transcription elongation, termination and antitermination
NPD12_3660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NPD12_3664	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NPD12_3666	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NPD12_3667	COG4956	integral membrane protein (PIN domain superfamily)
NPD12_367	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NPD12_3670	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NPD12_3671	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NPD12_3672	COG0542	response to heat
NPD12_3674	COG3880	PFAM UvrB UvrC protein
NPD12_3677	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NPD12_368	COG0281	malic enzyme
NPD12_3689	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NPD12_369	COG1546	Belongs to the CinA family
NPD12_369	COG1058	Belongs to the CinA family
NPD12_3691	COG0423	glycine-tRNA ligase activity
NPD12_3693	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NPD12_3695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NPD12_3697	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NPD12_3698	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NPD12_37	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NPD12_370	COG1073	alpha beta
NPD12_3701	COG2208	phosphoserine phosphatase activity
NPD12_3709	COG1098	S1 RNA binding domain
NPD12_371	COG1363	Peptidase, m42
NPD12_3714	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
NPD12_372	COG2720	vancomycin resistance protein
NPD12_373	COG2720	vancomycin resistance protein
NPD12_374	COG1533	DNA photolyase activity
NPD12_375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NPD12_376	COG1307	EDD domain protein, DegV family
NPD12_381	COG0726	polysaccharide deacetylase
NPD12_3812	COG1609	Transcriptional regulator
NPD12_382	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NPD12_384	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NPD12_388	COG0148	phosphopyruvate hydratase activity
NPD12_39	COG0653	protein targeting
NPD12_390	COG0557	exoribonuclease II activity
NPD12_391	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NPD12_395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPD12_396	COG1486	melibiose metabolic process
NPD12_398	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPD12_40	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NPD12_404	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPD12_406	COG0745	RESPONSE REGULATOR receiver
NPD12_409	COG2205	protein histidine kinase activity
NPD12_41	COG2814	Major facilitator Superfamily
NPD12_410	COG0662	Cupin 2, conserved barrel domain protein
NPD12_412	COG0833	amino acid
NPD12_417	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NPD12_418	COG2176	DNA-directed DNA polymerase activity
NPD12_420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NPD12_424	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPD12_426	COG2323	membrane
NPD12_43	COG1309	transcriptional regulator
NPD12_430	COG0785	Cytochrome C biogenesis protein
NPD12_431	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPD12_433	COG2205	protein histidine kinase activity
NPD12_434	COG0277	FAD linked oxidase domain protein
NPD12_435	COG1486	melibiose metabolic process
NPD12_436	COG1263	PTS System
NPD12_436	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_439	COG2190	(PTS) system
NPD12_440	COG0745	RESPONSE REGULATOR receiver
NPD12_441	COG5002	protein histidine kinase activity
NPD12_442	COG1136	(ABC) transporter
NPD12_443	COG0577	efflux transmembrane transporter activity
NPD12_444	COG1263	PTS System
NPD12_444	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_445	COG1486	melibiose metabolic process
NPD12_446	COG2190	(PTS) system
NPD12_446	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_446	COG1263	PTS System
NPD12_448	COG1278	Cold shock
NPD12_45	COG0024	Methionine aminopeptidase
NPD12_450	COG1959	2 iron, 2 sulfur cluster binding
NPD12_451	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NPD12_452	COG2910	NAD(P)H-binding
NPD12_453	COG1737	Transcriptional regulator
NPD12_454	COG1263	PTS System
NPD12_454	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_456	COG1263	PTS System
NPD12_456	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_456	COG2190	(PTS) system
NPD12_457	COG0129	dihydroxy-acid dehydratase activity
NPD12_459	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPD12_46	COG0778	Nitroreductase
NPD12_461	COG0745	RESPONSE REGULATOR receiver
NPD12_462	COG2770	Histidine kinase
NPD12_462	COG2205	protein histidine kinase activity
NPD12_463	COG0463	Glycosyl transferase, family 2
NPD12_464	COG2246	polysaccharide biosynthetic process
NPD12_465	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NPD12_468	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_469	COG1120	ATPase activity
NPD12_47	COG1328	CTP reductase activity
NPD12_472	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPD12_473	COG1609	Transcriptional regulator
NPD12_473	COG2207	Transcriptional regulator
NPD12_474	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPD12_475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_476	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_477	COG1120	ATPase activity
NPD12_478	COG1132	(ABC) transporter
NPD12_48	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NPD12_482	COG0745	RESPONSE REGULATOR receiver
NPD12_483	COG2205	protein histidine kinase activity
NPD12_485	COG1136	(ABC) transporter
NPD12_486	COG0577	efflux transmembrane transporter activity
NPD12_489	COG1346	cytolysis
NPD12_492	COG4868	Belongs to the UPF0371 family
NPD12_497	COG4251	negative regulation of phosphorylation
NPD12_497	COG3706	GGDEF domain
NPD12_497	COG2203	Gaf domain
NPD12_497	COG5001	Diguanylate cyclase
NPD12_5	COG3956	TIGRFAM MazG family protein
NPD12_50	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NPD12_500	COG5002	protein histidine kinase activity
NPD12_504	COG5002	protein histidine kinase activity
NPD12_505	COG0037	tRNA processing
NPD12_506	COG3800	Transcriptional regulator
NPD12_506	COG1396	sequence-specific DNA binding
NPD12_507	COG0531	amino acid
NPD12_508	COG0006	proline dipeptidase activity
NPD12_514	COG0671	phosphoesterase, PA-phosphatase related
NPD12_516	COG0745	RESPONSE REGULATOR receiver
NPD12_517	COG5002	protein histidine kinase activity
NPD12_519	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NPD12_52	COG1160	GTP binding
NPD12_520	COG0398	Pfam SNARE associated Golgi protein
NPD12_526	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NPD12_530	COG5002	protein histidine kinase activity
NPD12_531	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPD12_532	COG4656	Part of a membrane complex involved in electron transport
NPD12_533	COG4658	electron transport chain
NPD12_534	COG4659	FMN binding
NPD12_535	COG4660	Part of a membrane complex involved in electron transport
NPD12_536	COG4657	Part of a membrane complex involved in electron transport
NPD12_537	COG1245	4Fe-4S binding domain
NPD12_537	COG2878	Part of a membrane complex involved in electron transport
NPD12_541	COG1477	protein flavinylation
NPD12_549	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NPD12_55	COG0438	transferase activity, transferring glycosyl groups
NPD12_550	COG0573	inorganic phosphate transmembrane transporter activity
NPD12_554	COG0531	amino acid
NPD12_558	COG0629	single-stranded DNA binding
NPD12_56	COG0613	PHP domain protein
NPD12_563	COG0457	Tetratricopeptide repeat
NPD12_563	COG0705	Rhomboid family
NPD12_565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NPD12_574	COG3442	glutamine amidotransferase
NPD12_575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NPD12_576	COG1482	cell wall glycoprotein biosynthetic process
NPD12_578	COG1968	undecaprenyl-diphosphatase activity
NPD12_585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NPD12_587	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NPD12_588	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NPD12_589	COG0473	3-isopropylmalate dehydrogenase activity
NPD12_59	COG0583	DNA-binding transcription factor activity
NPD12_590	COG1126	abc transporter atp-binding protein
NPD12_591	COG1757	Na H antiporter
NPD12_592	COG2155	Conserved Protein
NPD12_594	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NPD12_595	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NPD12_6	COG2244	polysaccharide biosynthetic process
NPD12_60	COG1404	Belongs to the peptidase S8 family
NPD12_603	COG0375	protein maturation
NPD12_606	COG1074	ATP-dependent DNA helicase activity
NPD12_607	COG0840	transmembrane signaling receptor activity
NPD12_609	COG1752	Esterase of the alpha-beta hydrolase superfamily
NPD12_61	COG0583	DNA-binding transcription factor activity
NPD12_614	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPD12_615	COG2226	methyltransferase
NPD12_616	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NPD12_617	COG0352	thiamine-phosphate diphosphorylase activity
NPD12_618	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NPD12_619	COG0352	thiamine-phosphate diphosphorylase activity
NPD12_619	COG0351	phosphomethylpyrimidine kinase
NPD12_622	COG0559	Belongs to the binding-protein-dependent transport system permease family
NPD12_625	COG0410	ABC transporter
NPD12_629	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_63	COG0825	malonyl-CoA metabolic process
NPD12_631	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NPD12_635	COG2226	methyltransferase
NPD12_636	COG3655	Transcriptional regulator
NPD12_638	COG0420	3'-5' exonuclease activity
NPD12_639	COG0419	ATPase involved in DNA repair
NPD12_64	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NPD12_641	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPD12_643	COG0640	Transcriptional regulator
NPD12_644	COG2217	Heavy metal translocating P-type atpase
NPD12_65	COG0439	Biotin carboxylase
NPD12_650	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NPD12_651	COG5434	Belongs to the glycosyl hydrolase 28 family
NPD12_651	COG4632	Exopolysaccharide biosynthesis protein
NPD12_659	COG1131	(ABC) transporter
NPD12_662	COG1994	Peptidase M50
NPD12_668	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NPD12_669	COG1028	Short-chain dehydrogenase reductase Sdr
NPD12_67	COG0511	ligase activity, forming carbon-carbon bonds
NPD12_672	COG2267	carboxylic ester hydrolase activity
NPD12_673	COG0745	RESPONSE REGULATOR receiver
NPD12_675	COG0840	transmembrane signaling receptor activity
NPD12_676	COG2204	response regulator
NPD12_677	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NPD12_678	COG1199	ATP-dependent helicase activity
NPD12_68	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NPD12_682	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NPD12_684	COG2703	oxygen carrier activity
NPD12_69	COG1028	Short-chain dehydrogenase reductase Sdr
NPD12_694	COG1132	(ABC) transporter
NPD12_697	COG1136	(ABC) transporter
NPD12_7	COG2002	toxin-antitoxin pair type II binding
NPD12_70	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NPD12_700	COG0531	amino acid
NPD12_701	COG1522	sequence-specific DNA binding
NPD12_703	COG0531	amino acid
NPD12_704	COG0531	amino acid
NPD12_705	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NPD12_706	COG2333	competence protein COMEC
NPD12_706	COG0658	competence protein
NPD12_708	COG2059	Chromate
NPD12_709	COG2059	Chromate
NPD12_710	COG2337	Toxic component of a toxin-antitoxin (TA) module
NPD12_712	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NPD12_712	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NPD12_715	COG0006	proline dipeptidase activity
NPD12_72	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPD12_720	COG1073	alpha beta
NPD12_722	COG1966	Carbon starvation protein
NPD12_725	COG0488	(ABC) transporter
NPD12_728	COG0653	protein targeting
NPD12_73	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPD12_730	COG1725	Transcriptional regulator
NPD12_731	COG1131	(ABC) transporter
NPD12_734	COG0840	transmembrane signaling receptor activity
NPD12_737	COG1176	ABC-type spermidine putrescine transport system, permease component I
NPD12_738	COG1177	transmembrane transport
NPD12_740	COG1301	dicarboxylic acid transport
NPD12_744	COG3409	Peptidoglycan-binding domain 1 protein
NPD12_749	COG1357	PFAM Pentapeptide repeats (8 copies)
NPD12_750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPD12_750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPD12_754	COG3279	Response regulator of the LytR AlgR family
NPD12_76	COG0739	heme binding
NPD12_762	COG1132	(ABC) transporter
NPD12_766	COG1136	(ABC) transporter
NPD12_770	COG1307	EDD domain protein, DegV family
NPD12_772	COG1368	sulfuric ester hydrolase activity
NPD12_774	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NPD12_780	COG2207	Transcriptional regulator
NPD12_780	COG3708	Transcriptional regulator
NPD12_784	COG0745	RESPONSE REGULATOR receiver
NPD12_785	COG2205	protein histidine kinase activity
NPD12_786	COG1876	peptidase activity
NPD12_788	COG5002	protein histidine kinase activity
NPD12_790	COG0784	Response regulator, receiver
NPD12_791	COG5002	protein histidine kinase activity
NPD12_792	COG0772	Belongs to the SEDS family
NPD12_793	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NPD12_795	COG1132	(ABC) transporter
NPD12_799	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPD12_8	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NPD12_800	COG2207	Transcriptional regulator
NPD12_801	COG1396	sequence-specific DNA binding
NPD12_803	COG3279	Response regulator of the LytR AlgR family
NPD12_807	COG0346	lactoylglutathione lyase activity
NPD12_808	COG1193	negative regulation of DNA recombination
NPD12_814	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPD12_816	COG0513	Belongs to the DEAD box helicase family
NPD12_821	COG0583	DNA-binding transcription factor activity
NPD12_825	COG2949	membrane
NPD12_827	COG0494	nUDIX hydrolase
NPD12_830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NPD12_832	COG3711	transcriptional antiterminator
NPD12_833	COG2190	(PTS) system
NPD12_833	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPD12_833	COG1263	PTS System
NPD12_834	COG0613	PHP domain protein
NPD12_835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NPD12_837	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
NPD12_844	COG4120	Belongs to the binding-protein-dependent transport system permease family
NPD12_845	COG1122	ATPase activity
NPD12_850	COG2112	serine threonine protein kinase
NPD12_853	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NPD12_854	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NPD12_859	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NPD12_863	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_864	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_865	COG1120	ATPase activity
NPD12_867	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NPD12_869	COG0840	transmembrane signaling receptor activity
NPD12_872	COG0509	glycine decarboxylation via glycine cleavage system
NPD12_873	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NPD12_874	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NPD12_875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPD12_876	COG0095	Lipoate-protein ligase
NPD12_880	COG3328	transposase activity
NPD12_881	COG0745	RESPONSE REGULATOR receiver
NPD12_882	COG5002	protein histidine kinase activity
NPD12_883	COG0577	efflux transmembrane transporter activity
NPD12_883	COG1136	(ABC) transporter
NPD12_885	COG1846	Transcriptional regulator
NPD12_890	COG4185	zeta toxin
NPD12_891	COG1476	TRANSCRIPTIONal
NPD12_894	COG0789	Transcriptional regulator
NPD12_898	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NPD12_899	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NPD12_9	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NPD12_900	COG3973	AAA domain
NPD12_903	COG3708	Transcriptional regulator
NPD12_903	COG2207	Transcriptional regulator
NPD12_904	COG0697	spore germination
NPD12_906	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPD12_907	COG0840	transmembrane signaling receptor activity
NPD12_909	COG0488	(ABC) transporter
NPD12_912	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPD12_914	COG0626	cystathionine gamma-synthase activity
NPD12_915	COG2226	methyltransferase
NPD12_917	COG2226	methyltransferase
NPD12_918	COG3708	Transcriptional regulator
NPD12_918	COG2207	Transcriptional regulator
NPD12_92	COG2081	HI0933 family
NPD12_923	COG1396	sequence-specific DNA binding
NPD12_940	COG0798	PFAM Bile acid sodium symporter
NPD12_942	COG2226	methyltransferase
NPD12_95	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NPD12_956	COG0352	thiamine-phosphate diphosphorylase activity
NPD12_956	COG0351	phosphomethylpyrimidine kinase
NPD12_959	COG1131	(ABC) transporter
NPD12_961	COG0745	RESPONSE REGULATOR receiver
NPD12_964	COG3708	Transcriptional regulator
NPD12_964	COG2207	Transcriptional regulator
NPD12_965	COG2205	protein histidine kinase activity
NPD12_968	COG1136	(ABC) transporter
NPD12_972	COG5002	protein histidine kinase activity
NPD12_972	COG3850	Histidine kinase
NPD12_974	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPD12_975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_976	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPD12_977	COG1120	ATPase activity
NPD12_98	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NPD12_980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NPD12_99	COG0305	Participates in initiation and elongation during chromosome replication