locus-tag	class	description
CPR_0002	COG0592	DNA-directed DNA polymerase activity
CPR_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CPR_0006	COG0187	DNA topoisomerase II activity
CPR_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPR_0010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CPR_0012	COG0579	oxidoreductase
CPR_0027	COG3481	metal-dependent phosphohydrolase, HD sub domain
CPR_0028	COG1376	ErfK ybiS ycfS ynhG family protein
CPR_0036	COG4536	flavin adenine dinucleotide binding
CPR_0037	COG0590	tRNA wobble adenosine to inosine editing
CPR_0042	COG0523	cobalamin synthesis protein
CPR_0044	COG0701	Predicted permease
CPR_0049	COG1114	Component of the transport system for branched-chain amino acids
CPR_0053	COG1131	(ABC) transporter
CPR_0054	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CPR_0055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CPR_0057	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CPR_0064	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CPR_0066	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CPR_0067	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CPR_0069	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CPR_0070	COG1428	Deoxynucleoside kinase
CPR_0072	COG1840	ABC-type Fe3 transport system, periplasmic component
CPR_0075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CPR_0079	COG0531	amino acid
CPR_0083	COG0058	SHG alpha-glucan phosphorylase activity
CPR_0087	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CPR_0089	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPR_0091	COG3711	transcriptional antiterminator
CPR_0092	COG2190	(PTS) system
CPR_0093	COG1263	PTS System
CPR_0093	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPR_0094	COG1309	transcriptional regulator
CPR_0096	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CPR_0098	COG1940	carbohydrate kinase activity
CPR_0099	COG1592	Rubrerythrin
CPR_0099	COG1773	rubredoxin
CPR_0100	COG0406	alpha-ribazole phosphatase activity
CPR_0108	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CPR_0110	COG4086	secreted protein
CPR_0113	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPR_0117	COG0745	RESPONSE REGULATOR receiver
CPR_0118	COG2205	protein histidine kinase activity
CPR_0119	COG1136	(ABC) transporter
CPR_0136	COG0488	(ABC) transporter
CPR_0137	COG1196	nuclear chromosome segregation
CPR_0140	COG0281	malic enzyme
CPR_0142	COG0583	DNA-binding transcription factor activity
CPR_0155	COG0531	amino acid
CPR_0156	COG1874	Beta-galactosidase
CPR_0165	COG0626	cystathionine gamma-synthase activity
CPR_0166	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPR_0172	COG1131	(ABC) transporter
CPR_0173	COG0778	Nitroreductase
CPR_0176	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CPR_0177	COG2731	YhcH YjgK YiaL family protein
CPR_0182	COG0310	cobalt ion transport
CPR_0184	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CPR_0188	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CPR_0189	COG0739	heme binding
CPR_0193	COG1937	Protein conserved in bacteria
CPR_0202	COG0668	transmembrane transport
CPR_0203	COG5398	heme oxygenase
CPR_0204	COG0420	3'-5' exonuclease activity
CPR_0205	COG0419	ATPase involved in DNA repair
CPR_0207	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CPR_0214	COG1120	ATPase activity
CPR_0215	COG4988	ABC transporter
CPR_0216	COG1132	(ABC) transporter
CPR_0217	COG2832	Protein of unknown function (DUF454)
CPR_0222	COG2271	Major facilitator Superfamily
CPR_0223	COG1840	ABC-type Fe3 transport system, periplasmic component
CPR_0225	COG5002	protein histidine kinase activity
CPR_0226	COG0745	RESPONSE REGULATOR receiver
CPR_0227	COG0475	glutathione-regulated potassium exporter activity
CPR_0235	COG2202	Pas domain
CPR_0235	COG2200	EAL domain
CPR_0235	COG2199	diguanylate cyclase activity
CPR_0236	COG0484	heat shock protein binding
CPR_0238	COG0443	Heat shock 70 kDa protein
CPR_0247	COG0668	transmembrane transport
CPR_0248	COG3142	Participates in the control of copper homeostasis
CPR_0251	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CPR_0253	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CPR_0256	COG0438	transferase activity, transferring glycosyl groups
CPR_0257	COG0438	transferase activity, transferring glycosyl groups
CPR_0266	COG2890	protein-(glutamine-N5) methyltransferase activity
CPR_0267	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CPR_0268	COG2002	toxin-antitoxin pair type II binding
CPR_0272	COG1295	ribonuclease BN
CPR_0273	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPR_0274	COG0629	single-stranded DNA binding
CPR_0275	COG0426	domain, Protein
CPR_0283	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CPR_0283	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CPR_0286	COG2337	Toxic component of a toxin-antitoxin (TA) module
CPR_0287	COG3959	Transketolase, thiamine diphosphate binding domain
CPR_0288	COG3958	Transketolase
CPR_0290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPR_0291	COG2884	Cell division ATP-binding protein ftsE
CPR_0292	COG2177	Part of the ABC transporter FtsEX involved in
CPR_0293	COG0793	Belongs to the peptidase S41A family
CPR_0293	COG3409	Peptidoglycan-binding domain 1 protein
CPR_0297	COG4555	ABC transporter
CPR_0299	COG2755	lipolytic protein G-D-S-L family
CPR_0299	COG0657	acetylesterase activity
CPR_0301	COG2186	Transcriptional regulator
CPR_0302	COG1620	l-lactate permease
CPR_0303	COG2086	electron transfer activity
CPR_0305	COG0277	FAD linked oxidase domain protein
CPR_0308	COG2205	protein histidine kinase activity
CPR_0311	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CPR_0313	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPR_0325	COG0312	modulator of DNA gyrase
CPR_0326	COG0312	modulator of DNA gyrase
CPR_0328	COG0514	ATP-dependent DNA helicase (RecQ)
CPR_0330	COG1716	ATPase activity
CPR_0332	COG0768	penicillin binding
CPR_0336	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CPR_0337	COG1481	regulation of sporulation
CPR_0340	COG0587	DNA-directed DNA polymerase activity
CPR_0342	COG0469	pyruvate kinase activity
CPR_0344	COG0300	oxidoreductase activity
CPR_0345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CPR_0347	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPR_0351	COG1002	Type II restriction enzyme, methylase subunits
CPR_0360	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CPR_0360	COG3408	Glycogen debranching enzyme
CPR_0362	COG4716	Myosin-crossreactive antigen
CPR_0364	COG1132	(ABC) transporter
CPR_0367	COG0726	polysaccharide deacetylase
CPR_0369	COG1802	Transcriptional regulator
CPR_0370	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CPR_0372	COG0531	amino acid
CPR_0378	COG0157	Belongs to the NadC ModD family
CPR_0382	COG1943	Transposase
CPR_0388	COG1114	Component of the transport system for branched-chain amino acids
CPR_0389	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPR_0391	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CPR_0392	COG1028	Short-chain dehydrogenase reductase Sdr
CPR_0395	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CPR_0396	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CPR_0397	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPR_0399	COG3716	PTS system mannose fructose sorbose family IID component
CPR_0403	COG1609	Transcriptional regulator
CPR_0404	COG0277	FAD linked oxidase domain protein
CPR_0410	COG0288	reversible hydration of carbon dioxide
CPR_0416	COG1609	Transcriptional regulator
CPR_0417	COG0366	Alpha amylase catalytic
CPR_0418	COG2190	(PTS) system
CPR_0418	COG1263	PTS System
CPR_0418	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPR_0420	COG0584	glycerophosphoryl diester phosphodiesterase
CPR_0433	COG1253	flavin adenine dinucleotide binding
CPR_0434	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CPR_0436	COG1725	Transcriptional regulator
CPR_0437	COG1131	(ABC) transporter
CPR_0440	COG0346	lactoylglutathione lyase activity
CPR_0442	COG1454	alcohol dehydrogenase
CPR_0444	COG0346	lactoylglutathione lyase activity
CPR_0445	COG0789	Transcriptional regulator
CPR_0449	COG5002	protein histidine kinase activity
CPR_0452	COG3944	biosynthesis protein
CPR_0453	COG0489	protein tyrosine kinase activity
CPR_0454	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CPR_0458	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CPR_0459	COG0438	transferase activity, transferring glycosyl groups
CPR_0463	COG3475	LICD family
CPR_0465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CPR_0468	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CPR_0469	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CPR_0474	COG2207	Transcriptional regulator
CPR_0477	COG1175	transmembrane transport
CPR_0478	COG0395	ABC-type sugar transport system, permease component
CPR_0479	COG4509	Sortase family
CPR_0486	COG3279	Response regulator of the LytR AlgR family
CPR_0489	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPR_0492	COG0561	phosphatase activity
CPR_0493	COG1846	Transcriptional regulator
CPR_0495	COG1132	(ABC) transporter
CPR_0499	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CPR_0500	COG3290	protein histidine kinase activity
CPR_0501	COG4565	transcriptional regulatory protein
CPR_0507	COG1454	alcohol dehydrogenase
CPR_0510	COG3104	oligopeptide transport
CPR_0512	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CPR_0514	COG1982	Orn Lys Arg decarboxylase major
CPR_0516	COG0010	Belongs to the arginase family
CPR_0517	COG3326	Membrane
CPR_0518	COG2217	Heavy metal translocating P-type atpase
CPR_0522	COG1174	glycine betaine transport
CPR_0523	COG1595	DNA-templated transcription, initiation
CPR_0525	COG1263	PTS System
CPR_0525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPR_0527	COG2188	Transcriptional regulator
CPR_0528	COG0768	penicillin binding
CPR_0532	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPR_0532	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CPR_0534	COG0432	Pfam Uncharacterised protein family UPF0047
CPR_0537	COG5426	von Willebrand factor, type A
CPR_0538	COG2972	Histidine kinase
CPR_0539	COG4753	response regulator
CPR_0539	COG2207	Transcriptional regulator
CPR_0541	COG1175	transmembrane transport
CPR_0543	COG0398	Pfam SNARE associated Golgi protein
CPR_0545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPR_0549	COG0306	phosphate transporter
CPR_0550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPR_0550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CPR_0550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPR_0551	COG1105	Belongs to the carbohydrate kinase PfkB family
CPR_0552	COG1349	DNA-binding transcription factor activity
CPR_0554	COG0628	permease
CPR_0556	COG0038	chloride channel
CPR_0558	COG1285	pathogenesis
CPR_0561	COG2816	NAD+ diphosphatase activity
CPR_0562	COG0019	diaminopimelate decarboxylase activity
CPR_0565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPR_0566	COG3973	AAA domain
CPR_0567	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPR_0568	COG0765	amino acid transport
CPR_0569	COG1126	abc transporter atp-binding protein
CPR_0570	COG1368	sulfuric ester hydrolase activity
CPR_0571	COG0463	Glycosyl transferase, family 2
CPR_0575	COG1368	sulfuric ester hydrolase activity
CPR_0577	COG1362	aminopeptidase activity
CPR_0579	COG0561	phosphatase activity
CPR_0580	COG1033	growth of symbiont in host cell
CPR_0580	COG2409	Drug exporters of the RND superfamily
CPR_0581	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CPR_0583	COG0561	phosphatase activity
CPR_0584	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CPR_0585	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CPR_0586	COG0438	transferase activity, transferring glycosyl groups
CPR_0589	COG3475	LICD family
CPR_0592	COG4193	domain, Protein
CPR_0592	COG5263	repeat protein
CPR_0596	COG4750	Nucleotidyl transferase
CPR_0599	COG1114	Component of the transport system for branched-chain amino acids
CPR_0602	COG0641	radical SAM
CPR_0603	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CPR_0604	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CPR_0605	COG0573	inorganic phosphate transmembrane transporter activity
CPR_0606	COG0581	inorganic phosphate transmembrane transporter activity
CPR_0607	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CPR_0608	COG0704	Plays a role in the regulation of phosphate uptake
CPR_0609	COG0745	RESPONSE REGULATOR receiver
CPR_0615	COG0697	spore germination
CPR_0621	COG2357	RelA SpoT domain protein
CPR_0623	COG1126	abc transporter atp-binding protein
CPR_0624	COG3864	Putative metallopeptidase domain
CPR_0630	COG3328	transposase activity
CPR_0636	COG1328	CTP reductase activity
CPR_0637	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CPR_0649	COG1695	Transcriptional regulator
CPR_0651	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CPR_0667	COG0756	dUTP diphosphatase activity
CPR_0669	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CPR_0670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CPR_0672	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CPR_0674	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CPR_0676	COG0151	Belongs to the GarS family
CPR_0682	COG1773	rubredoxin
CPR_0682	COG1592	Rubrerythrin
CPR_0687	COG3291	Pkd domain containing protein
CPR_0687	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CPR_0688	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CPR_0691	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CPR_0692	COG1605	Chorismate mutase
CPR_0692	COG0077	Prephenate dehydratase
CPR_0698	COG4152	abc transporter atp-binding protein
CPR_0699	COG1668	transmembrane transport
CPR_0700	COG1522	sequence-specific DNA binding
CPR_0701	COG0436	Aminotransferase
CPR_0706	COG1216	Glycosyl transferase, family 2
CPR_0707	COG0628	permease
CPR_0708	COG1349	DNA-binding transcription factor activity
CPR_0709	COG0561	phosphatase activity
CPR_0714	COG0583	DNA-binding transcription factor activity
CPR_0715	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPR_0719	COG5566	PFAM Mor transcription activator
CPR_0721	COG0785	Cytochrome C biogenesis protein
CPR_0725	COG1966	Carbon starvation protein
CPR_0727	COG1309	transcriptional regulator
CPR_0737	COG0402	S-adenosylhomocysteine deaminase activity
CPR_0739	COG0697	spore germination
CPR_0740	COG2508	Transcriptional regulator
CPR_0741	COG0242	peptide deformylase activity
CPR_0743	COG1011	Hydrolase
CPR_0748	COG2211	Major facilitator Superfamily
CPR_0749	COG2207	Transcriptional regulator
CPR_0750	COG3250	beta-galactosidase activity
CPR_0751	COG2610	gluconate transmembrane transporter activity
CPR_0753	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CPR_0754	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPR_0771	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CPR_0778	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPR_0779	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPR_0780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPR_0781	COG1120	ATPase activity
CPR_0782	COG0494	nUDIX hydrolase
CPR_0788	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CPR_0794	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPR_0795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPR_0796	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPR_0797	COG1120	ATPase activity
CPR_0803	COG0561	phosphatase activity
CPR_0805	COG3715	PTS system
CPR_0806	COG3716	PTS system mannose fructose sorbose family IID component
CPR_0816	COG2340	Cysteine-rich secretory protein family
CPR_0819	COG2409	Drug exporters of the RND superfamily
CPR_0822	COG2801	Transposase and inactivated derivatives
CPR_0827	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CPR_0828	COG0534	Mate efflux family protein
CPR_0829	COG0745	RESPONSE REGULATOR receiver
CPR_0831	COG5002	protein histidine kinase activity
CPR_0837	COG0577	efflux transmembrane transporter activity
CPR_0840	COG1592	Rubrerythrin
CPR_0842	COG1979	alcohol dehydrogenase
CPR_0844	COG3835	regulator
CPR_0845	COG2610	gluconate transmembrane transporter activity
CPR_0846	COG1929	Belongs to the glycerate kinase type-1 family
CPR_0848	COG0534	Mate efflux family protein
CPR_0850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CPR_0850	COG3291	Pkd domain containing protein
CPR_0854	COG0006	proline dipeptidase activity
CPR_0855	COG2309	aminopeptidase activity
CPR_0857	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPR_0858	COG3153	acetyltransferase
CPR_0866	COG0398	Pfam SNARE associated Golgi protein
CPR_0867	COG0386	Belongs to the glutathione peroxidase family
CPR_0868	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CPR_0870	COG0640	Transcriptional regulator
CPR_0871	COG5658	integral membrane protein
CPR_0879	COG1266	CAAX protease self-immunity
CPR_0886	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CPR_0898	COG0494	nUDIX hydrolase
CPR_0903	COG1609	Transcriptional regulator
CPR_0904	COG1653	transport
CPR_0905	COG1175	transmembrane transport
CPR_0906	COG0395	ABC-type sugar transport system, permease component
CPR_0907	COG3842	ATPase activity
CPR_0908	COG1621	beta-fructofuranosidase activity
CPR_0909	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPR_0917	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CPR_0927	COG1454	alcohol dehydrogenase
CPR_0931	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CPR_0934	COG3546	catalase activity
CPR_0935	COG1263	PTS System
CPR_0935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPR_0974	COG1151	hydroxylamine reductase activity
CPR_0983	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CPR_0984	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CPR_0986	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CPR_0987	COG1187	pseudouridine synthase activity
CPR_0991	COG1028	Short-chain dehydrogenase reductase Sdr
CPR_0994	COG0586	Pfam SNARE associated Golgi protein
CPR_0996	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CPR_0996	COG2199	diguanylate cyclase activity
CPR_0997	COG0778	Nitroreductase
CPR_1001	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPR_1002	COG3275	phosphorelay sensor kinase activity
CPR_1003	COG2197	response regulator
CPR_1012	COG0531	amino acid
CPR_1013	COG3976	FMN-binding domain protein
CPR_1013	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CPR_1019	COG1823	symporter activity
CPR_1020	COG0745	RESPONSE REGULATOR receiver
CPR_1023	COG5002	protein histidine kinase activity
CPR_1025	COG2081	HI0933 family
CPR_1029	COG1051	belongs to the nudix hydrolase family
CPR_1032	COG1846	Transcriptional regulator
CPR_1034	COG0531	amino acid
CPR_1035	COG2203	Gaf domain
CPR_1035	COG3706	GGDEF domain
CPR_1035	COG5001	Diguanylate cyclase
CPR_1035	COG4251	negative regulation of phosphorylation
CPR_1038	COG0569	domain protein
CPR_1038	COG0475	glutathione-regulated potassium exporter activity
CPR_1041	COG2706	6-phosphogluconolactonase activity
CPR_1053	COG0697	spore germination
CPR_1054	COG1288	antiporter activity
CPR_1055	COG2205	protein histidine kinase activity
CPR_1055	COG0784	Response regulator, receiver
CPR_1057	COG1760	l-serine dehydratase
CPR_1059	COG0037	tRNA processing
CPR_1061	COG2070	2-Nitropropane dioxygenase
CPR_1062	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CPR_1074	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CPR_1075	COG0598	Magnesium transport protein CorA
CPR_1076	COG1362	aminopeptidase activity
CPR_1089	COG0251	oxidation-reduction process
CPR_1091	COG0426	domain, Protein
CPR_1092	COG0613	PHP domain protein
CPR_1093	COG0512	Glutamine amidotransferase of anthranilate synthase
CPR_1093	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CPR_1095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPR_1098	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CPR_1099	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CPR_1099	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CPR_1102	COG0671	phosphoesterase, PA-phosphatase related
CPR_1105	COG0640	Transcriptional regulator
CPR_1106	COG1473	amidohydrolase
CPR_1108	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CPR_1114	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CPR_1115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CPR_1116	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CPR_1117	COG1120	ATPase activity
CPR_1120	COG1151	hydroxylamine reductase activity
CPR_1123	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CPR_1124	COG2897	thiosulfate sulfurtransferase activity
CPR_1128	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CPR_1130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CPR_1130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CPR_1135	COG1846	Transcriptional regulator
CPR_1137	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CPR_1138	COG1028	Short-chain dehydrogenase reductase Sdr
CPR_1139	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CPR_1140	COG0511	ligase activity, forming carbon-carbon bonds
CPR_1141	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CPR_1142	COG0439	Biotin carboxylase
CPR_1147	COG1187	pseudouridine synthase activity
CPR_1148	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CPR_1150	COG2081	HI0933 family
CPR_1161	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CPR_1162	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CPR_1167	COG0281	malic enzyme
CPR_1175	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CPR_1179	COG4974	Belongs to the 'phage' integrase family
CPR_1181	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CPR_1182	COG0833	amino acid
CPR_1183	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CPR_1185	COG2364	Membrane
CPR_1192	COG0708	Exodeoxyribonuclease III
CPR_1193	COG0456	acetyltransferase
CPR_1196	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CPR_1205	COG1482	cell wall glycoprotein biosynthetic process
CPR_1206	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CPR_1207	COG3442	glutamine amidotransferase
CPR_1212	COG0531	amino acid
CPR_1218	COG0534	Mate efflux family protein
CPR_1224	COG0564	pseudouridine synthase activity
CPR_1225	COG1473	amidohydrolase
CPR_1226	COG0210	DNA helicase
CPR_1227	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CPR_1230	COG0735	belongs to the Fur family
CPR_1231	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CPR_1232	COG2233	PERMEase
CPR_1236	COG2875	Belongs to the precorrin methyltransferase family
CPR_1243	COG3584	3D domain protein
CPR_1243	COG1388	LysM domain
CPR_1245	COG3103	Sh3 type 3 domain protein
CPR_1255	COG2239	Acts as a magnesium transporter
CPR_1258	COG0392	lysyltransferase activity
CPR_1258	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPR_1259	COG0392	lysyltransferase activity
CPR_1259	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPR_1263	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CPR_1263	COG0493	'glutamate synthase
CPR_1266	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPR_1266	COG4991	sh3 domain protein
CPR_1266	COG3103	Sh3 type 3 domain protein
CPR_1270	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPR_1281	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPR_1282	COG1289	transmembrane transporter activity
CPR_1283	COG1846	Transcriptional regulator
CPR_1287	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPR_1291	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CPR_1292	COG0557	exoribonuclease II activity
CPR_1295	COG0148	phosphopyruvate hydratase activity
CPR_1297	COG0531	amino acid
CPR_1299	COG0149	triose-phosphate isomerase activity
CPR_1301	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CPR_1302	COG2390	Transcriptional regulator
CPR_1303	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CPR_1306	COG1744	ABC transporter substrate-binding protein PnrA-like
CPR_1309	COG0561	phosphatase activity
CPR_1310	COG2720	vancomycin resistance protein
CPR_1318	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CPR_1320	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CPR_1321	COG1045	serine acetyltransferase
CPR_1322	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CPR_1323	COG2239	Acts as a magnesium transporter
CPR_1324	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CPR_1325	COG0765	amino acid transport
CPR_1328	COG1597	lipid kinase activity
CPR_1329	COG1183	phosphatidylcholine synthase activity
CPR_1332	COG2719	SpoVR family
CPR_1334	COG2766	serine protein kinase
CPR_1335	COG0514	ATP-dependent DNA helicase (RecQ)
CPR_1338	COG0351	phosphomethylpyrimidine kinase
CPR_1340	COG1609	Transcriptional regulator
CPR_1347	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CPR_1348	COG2323	membrane
CPR_1353	COG0791	NLP P60 protein
CPR_1353	COG0741	lytic transglycosylase activity
CPR_1356	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CPR_1365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CPR_1371	COG1876	peptidase activity
CPR_1375	COG0024	Methionine aminopeptidase
CPR_1382	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CPR_1383	COG0470	DNA polymerase III
CPR_1383	COG1067	ATP-dependent peptidase activity
CPR_1385	COG0740	serine-type endopeptidase activity
CPR_1403	COG1104	cysteine desulfurase activity
CPR_1405	COG0383	alpha-mannosidase activity
CPR_1406	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CPR_1406	COG0646	methionine synthase
CPR_1408	COG1115	amino acid carrier protein
CPR_1409	COG4684	Psort location CytoplasmicMembrane, score
CPR_1410	COG3191	aminopeptidase activity
CPR_1420	COG0113	porphobilinogen synthase activity
CPR_1425	COG2221	Nitrite and sulphite reductase 4Fe-4S
CPR_1432	COG2207	Transcriptional regulator
CPR_1432	COG1917	Cupin 2, conserved barrel domain protein
CPR_1438	COG0705	Rhomboid family
CPR_1438	COG0457	Tetratricopeptide repeat
CPR_1439	COG1164	Oligoendopeptidase f
CPR_1442	COG1121	(ABC) transporter
CPR_1443	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CPR_1446	COG0205	6-phosphofructokinase activity
CPR_1448	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CPR_1449	COG0488	(ABC) transporter
CPR_1450	COG0756	dUTP diphosphatase activity
CPR_1453	COG1272	protein, Hemolysin III
CPR_1454	COG0583	DNA-binding transcription factor activity
CPR_1456	COG0726	polysaccharide deacetylase
CPR_1459	COG0659	secondary active sulfate transmembrane transporter activity
CPR_1461	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CPR_1461	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CPR_1464	COG1116	anion transmembrane transporter activity
CPR_1475	COG0586	Pfam SNARE associated Golgi protein
CPR_1476	COG0586	Pfam SNARE associated Golgi protein
CPR_1477	COG0037	tRNA processing
CPR_1480	COG0658	competence protein
CPR_1480	COG2333	competence protein COMEC
CPR_1482	COG3279	Response regulator of the LytR AlgR family
CPR_1485	COG3583	domain protein
CPR_1485	COG3584	3D domain protein
CPR_1487	COG0488	(ABC) transporter
CPR_1499	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CPR_1501	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CPR_1508	COG5298	Protein conserved in bacteria
CPR_1510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPR_1511	COG1621	beta-fructofuranosidase activity
CPR_1512	COG1609	Transcriptional regulator
CPR_1516	COG4086	secreted protein
CPR_1517	COG0464	growth
CPR_1518	COG0243	molybdopterin cofactor binding
CPR_1519	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CPR_1522	COG1523	belongs to the glycosyl hydrolase 13 family
CPR_1527	COG4129	membrane
CPR_1528	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CPR_1530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CPR_1530	COG2199	diguanylate cyclase activity
CPR_1539	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CPR_1541	COG0561	phosphatase activity
CPR_1547	COG2252	PERMEase
CPR_1552	COG1744	ABC transporter substrate-binding protein PnrA-like
CPR_1557	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CPR_1558	COG1523	belongs to the glycosyl hydrolase 13 family
CPR_1564	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CPR_1564	COG0392	lysyltransferase activity
CPR_1569	COG0352	thiamine-phosphate diphosphorylase activity
CPR_1574	COG2814	Major facilitator Superfamily
CPR_1582	COG0726	polysaccharide deacetylase
CPR_1585	COG0398	Pfam SNARE associated Golgi protein
CPR_1587	COG0739	heme binding
CPR_1587	COG0741	lytic transglycosylase activity
CPR_1587	COG1196	nuclear chromosome segregation
CPR_1591	COG3973	AAA domain
CPR_1599	COG1879	ABC-type sugar transport system periplasmic component
CPR_1600	COG1172	Belongs to the binding-protein-dependent transport system permease family
CPR_1603	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CPR_1605	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CPR_1608	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CPR_1613	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CPR_1614	COG1269	ATP hydrolysis coupled proton transport
CPR_1619	COG2244	polysaccharide biosynthetic process
CPR_1625	COG1522	sequence-specific DNA binding
CPR_1626	COG2155	Conserved Protein
CPR_1636	COG1994	Peptidase M50
CPR_1637	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CPR_1641	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CPR_1643	COG2359	stage V sporulation protein S
CPR_1646	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CPR_1649	COG0740	serine-type endopeptidase activity
CPR_1650	COG0527	aspartate kinase activity
CPR_1653	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CPR_1654	COG0196	riboflavin kinase activity
CPR_1656	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CPR_1657	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CPR_1658	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CPR_1660	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CPR_1661	COG0195	Participates in both transcription termination and antitermination
CPR_1667	COG4589	Belongs to the CDS family
CPR_1669	COG0233	cytoplasmic translational termination
CPR_1672	COG0052	Belongs to the universal ribosomal protein uS2 family
CPR_1673	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CPR_1674	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CPR_1675	COG0758	DNA mediated transformation
CPR_1676	COG0606	chelatase, subunit chli
CPR_1679	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CPR_1680	COG0335	large ribosomal subunit rRNA binding
CPR_1684	COG0228	four-way junction DNA binding
CPR_1685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CPR_1687	COG0552	protein localization to endoplasmic reticulum
CPR_1691	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CPR_1693	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CPR_1696	COG0280	phosphate acetyltransferase
CPR_1701	COG0742	ribosomal rna small subunit methyltransferase
CPR_1702	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CPR_1703	COG1461	Dihydroxyacetone kinase
CPR_1707	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CPR_1710	COG0631	protein serine/threonine phosphatase activity
CPR_1712	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CPR_1712	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CPR_1713	COG2738	Putative neutral zinc metallopeptidase
CPR_1716	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CPR_1717	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CPR_1718	COG1758	RNA polymerase activity
CPR_1721	COG1561	YicC-like family, N-terminal region
CPR_1722	COG2252	PERMEase
CPR_1726	COG1160	GTP binding
CPR_1727	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPR_1728	COG5002	protein histidine kinase activity
CPR_1731	COG1873	PFAM PRC-barrel domain
CPR_1732	COG1191	sigma factor activity
CPR_1733	COG1191	sigma factor activity
CPR_1735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CPR_1738	COG1191	sigma factor activity
CPR_1743	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CPR_1745	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CPR_1746	COG0735	belongs to the Fur family
CPR_1748	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CPR_1751	COG0628	permease
CPR_1754	COG0822	iron-sulfur transferase activity
CPR_1756	COG1959	2 iron, 2 sulfur cluster binding
CPR_1757	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CPR_1758	COG3706	GGDEF domain
CPR_1758	COG0745	RESPONSE REGULATOR receiver
CPR_1763	COG0303	'Molybdopterin
CPR_1767	COG0243	molybdopterin cofactor binding
CPR_1768	COG2081	HI0933 family
CPR_1770	COG1686	Belongs to the peptidase S11 family
CPR_1772	COG3874	Sporulation protein YtfJ
CPR_1775	COG1686	Belongs to the peptidase S11 family
CPR_1776	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CPR_1777	COG4974	Belongs to the 'phage' integrase family
CPR_1779	COG0494	nUDIX hydrolase
CPR_1781	COG0745	RESPONSE REGULATOR receiver
CPR_1782	COG0750	zinc metalloprotease
CPR_1783	COG0497	DNA recombination
CPR_1786	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CPR_1788	COG0142	geranyltranstransferase activity
CPR_1789	COG1722	exodeoxyribonuclease VII activity
CPR_1793	COG1302	Protein conserved in bacteria
CPR_1801	COG3854	ATPases associated with a variety of cellular activities
CPR_1803	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CPR_1812	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CPR_1816	COG0116	Belongs to the methyltransferase superfamily
CPR_1817	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CPR_1818	COG0564	pseudouridine synthase activity
CPR_1819	COG3599	regulation of cell shape
CPR_1821	COG1799	cell septum assembly
CPR_1822	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CPR_1824	COG3856	small basic protein
CPR_1826	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CPR_1827	COG0772	Belongs to the SEDS family
CPR_1829	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CPR_1831	COG0768	penicillin binding
CPR_1833	COG0275	rRNA processing
CPR_1835	COG0012	GTP binding
CPR_1841	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CPR_1845	COG1683	Conserved Protein
CPR_1846	COG0768	penicillin binding
CPR_1848	COG0826	peptidase U32
CPR_1849	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CPR_1853	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPR_1854	COG0569	domain protein
CPR_1855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CPR_1856	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CPR_1857	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CPR_1862	COG0494	nUDIX hydrolase
CPR_1871	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CPR_1874	COG0436	Aminotransferase
CPR_1875	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CPR_1878	COG0726	polysaccharide deacetylase
CPR_1880	COG0628	permease
CPR_1881	COG1316	TRANSCRIPTIONal
CPR_1882	COG1272	protein, Hemolysin III
CPR_1884	COG0038	chloride channel
CPR_1885	COG0285	dihydrofolate synthase activity
CPR_1890	COG0612	Peptidase, M16
CPR_1891	COG0745	RESPONSE REGULATOR receiver
CPR_1892	COG5002	protein histidine kinase activity
CPR_1893	COG1028	Short-chain dehydrogenase reductase Sdr
CPR_1896	COG2966	Psort location CytoplasmicMembrane, score
CPR_1898	COG1937	Protein conserved in bacteria
CPR_1901	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPR_1902	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CPR_1903	COG1490	D-aminoacyl-tRNA deacylase activity
CPR_1904	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CPR_1905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPR_1907	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPR_1908	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CPR_1911	COG1862	Preprotein translocase
CPR_1912	COG0343	queuine tRNA-ribosyltransferase activity
CPR_1917	COG0737	Belongs to the 5'-nucleotidase family
CPR_1918	COG0737	Belongs to the 5'-nucleotidase family
CPR_1923	COG1739	Uncharacterized protein family UPF0029
CPR_1924	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CPR_1927	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CPR_1931	COG1115	amino acid carrier protein
CPR_1936	COG1176	ABC-type spermidine putrescine transport system, permease component I
CPR_1937	COG1177	transmembrane transport
CPR_1938	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CPR_1940	COG1254	Belongs to the acylphosphatase family
CPR_1943	COG1686	Belongs to the peptidase S11 family
CPR_1948	COG1346	cytolysis
CPR_1951	COG1228	amidohydrolase
CPR_1952	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
CPR_1953	COG5002	protein histidine kinase activity
CPR_1954	COG5002	protein histidine kinase activity
CPR_1956	COG2267	carboxylic ester hydrolase activity
CPR_1962	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPR_1962	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CPR_1967	COG5434	Belongs to the glycosyl hydrolase 28 family
CPR_1967	COG4632	Exopolysaccharide biosynthesis protein
CPR_1971	COG1957	nucleoside hydrolase
CPR_1973	COG2384	SAM-dependent methyltransferase
CPR_1975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CPR_1976	COG0358	DNA primase activity
CPR_1979	COG0577	efflux transmembrane transporter activity
CPR_1979	COG1136	(ABC) transporter
CPR_1983	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPR_1983	COG0574	Belongs to the PEP-utilizing enzyme family
CPR_1984	COG0517	IMP dehydrogenase activity
CPR_1989	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CPR_1991	COG1480	7TM receptor with intracellular HD hydrolase
CPR_1994	COG1610	YqeY-like protein
CPR_1995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CPR_1996	COG0537	adenosine 5'-monophosphoramidase activity
CPR_1997	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CPR_1998	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CPR_2000	COG1725	Transcriptional regulator
CPR_2003	COG1131	(ABC) transporter
CPR_2008	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CPR_2014	COG0268	Binds directly to 16S ribosomal RNA
CPR_2018	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CPR_2023	COG1067	ATP-dependent peptidase activity
CPR_2026	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CPR_2029	COG0076	glutamate decarboxylase activity
CPR_2031	COG0531	amino acid
CPR_2036	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CPR_2036	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CPR_2037	COG0612	Peptidase, M16
CPR_2039	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CPR_2040	COG0187	DNA topoisomerase II activity
CPR_2041	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CPR_2044	COG1971	Probably functions as a manganese efflux pump
CPR_2046	COG0531	amino acid
CPR_2049	COG0383	alpha-mannosidase activity
CPR_2050	COG0395	ABC-type sugar transport system, permease component
CPR_2051	COG4209	transmembrane transport
CPR_2053	COG4149	molybdate abc transporter
CPR_2054	COG0725	ABC transporter, periplasmic molybdate-binding protein
CPR_2055	COG0521	Mo-molybdopterin cofactor biosynthetic process
CPR_2056	COG2207	Transcriptional regulator
CPR_2056	COG4753	response regulator
CPR_2057	COG2972	Histidine kinase
CPR_2059	COG2348	transferase activity, transferring amino-acyl groups
CPR_2060	COG1695	Transcriptional regulator
CPR_2061	COG1126	abc transporter atp-binding protein
CPR_2065	COG1550	Protein conserved in bacteria
CPR_2067	COG2264	protein methyltransferase activity
CPR_2074	COG0697	spore germination
CPR_2076	COG5002	protein histidine kinase activity
CPR_2077	COG0745	RESPONSE REGULATOR receiver
CPR_2079	COG1136	(ABC) transporter
CPR_2080	COG0577	efflux transmembrane transporter activity
CPR_2087	COG1596	polysaccharide export
CPR_2087	COG1555	photosystem II stabilization
CPR_2088	COG1686	Belongs to the peptidase S11 family
CPR_2089	COG0564	pseudouridine synthase activity
CPR_2090	COG1316	TRANSCRIPTIONal
CPR_2091	COG1713	HD superfamily hydrolase involved in NAD metabolism
CPR_2093	COG1534	Rna-binding protein
CPR_2094	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CPR_2095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CPR_2097	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CPR_2098	COG1530	ribonuclease E activity
CPR_2101	COG1994	Peptidase M50
CPR_2103	COG0772	Belongs to the SEDS family
CPR_2105	COG2894	cell division
CPR_2106	COG0850	regulation of cytokinetic process
CPR_2110	COG1077	Cell shape determining protein MreB Mrl
CPR_2114	COG0613	PHP domain protein
CPR_2115	COG2195	Cleaves the N-terminal amino acid of tripeptides
CPR_2117	COG0539	negative regulation of cytoplasmic translation
CPR_2124	COG1263	PTS System
CPR_2124	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CPR_2124	COG2190	(PTS) system
CPR_2125	COG0803	Belongs to the bacterial solute-binding protein 9 family
CPR_2126	COG4717	serine-type aminopeptidase activity
CPR_2132	COG0802	atpase or kinase
CPR_2133	COG1214	PFAM Peptidase M22, glycoprotease
CPR_2134	COG0456	acetyltransferase
CPR_2136	COG2183	response to ionizing radiation
CPR_2137	COG2234	aminopeptidase activity
CPR_2143	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CPR_2145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CPR_2156	COG1609	Transcriptional regulator
CPR_2158	COG2385	sporulation resulting in formation of a cellular spore
CPR_2163	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CPR_2166	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CPR_2168	COG0356	it plays a direct role in the translocation of protons across the membrane
CPR_2170	COG0183	Belongs to the thiolase family
CPR_2171	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CPR_2173	COG0698	ribose 5-phosphate isomerase
CPR_2174	COG0009	L-threonylcarbamoyladenylate synthase
CPR_2176	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CPR_2178	COG1435	thymidine kinase activity
CPR_2179	COG0254	rRNA binding
CPR_2180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CPR_2181	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CPR_2182	COG0504	CTP synthase activity
CPR_2183	COG4506	Protein conserved in bacteria
CPR_2184	COG0482	sulfurtransferase activity
CPR_2188	COG4242	Belongs to the peptidase S51 family
CPR_2190	COG4466	Protein conserved in bacteria
CPR_2192	COG3642	lipopolysaccharide core region biosynthetic process
CPR_2193	COG0438	transferase activity, transferring glycosyl groups
CPR_2198	COG3192	ethanolamine utilization protein
CPR_2200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPR_2206	COG0425	Belongs to the sulfur carrier protein TusA family
CPR_2207	COG1368	sulfuric ester hydrolase activity
CPR_2209	COG5002	protein histidine kinase activity
CPR_2210	COG0745	RESPONSE REGULATOR receiver
CPR_2216	COG2195	Cleaves the N-terminal amino acid of tripeptides
CPR_2242	COG0747	negative chemotaxis
CPR_2249	COG1187	pseudouridine synthase activity
CPR_2254	COG4608	Belongs to the ABC transporter superfamily
CPR_2255	COG0444	Belongs to the ABC transporter superfamily
CPR_2257	COG0601	transmembrane transport
CPR_2261	COG0517	IMP dehydrogenase activity
CPR_2261	COG0516	GMP reductase activity
CPR_2271	COG1459	type II secretion system
CPR_2272	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CPR_2273	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CPR_2275	COG0459	protein refolding
CPR_2278	COG1403	HNH endonuclease
CPR_2281	COG0681	Belongs to the peptidase S26 family
CPR_2282	COG1132	(ABC) transporter
CPR_2283	COG1250	3-hydroxyacyl-CoA dehydrogenase
CPR_2285	COG2086	electron transfer activity
CPR_2286	COG1960	acyl-CoA dehydrogenase activity
CPR_2287	COG1024	Enoyl-CoA hydratase
CPR_2289	COG2217	Heavy metal translocating P-type atpase
CPR_2294	COG0662	Cupin 2, conserved barrel domain protein
CPR_2294	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CPR_2295	COG2723	6-phospho-beta-galactosidase activity
CPR_2296	COG1012	belongs to the aldehyde dehydrogenase family
CPR_2298	COG1073	alpha beta
CPR_2299	COG1187	pseudouridine synthase activity
CPR_2301	COG3764	Sortase (surface protein transpeptidase)
CPR_2303	COG1757	Na H antiporter
CPR_2319	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CPR_2326	COG5002	protein histidine kinase activity
CPR_2327	COG0745	RESPONSE REGULATOR receiver
CPR_2329	COG4496	protein, YerC YecD
CPR_2332	COG0058	SHG alpha-glucan phosphorylase activity
CPR_2336	COG3833	ABC-type maltose transport systems, permease component
CPR_2337	COG1175	transmembrane transport
CPR_2338	COG2182	Extracellular solute-binding protein
CPR_2339	COG3835	regulator
CPR_2340	COG3842	ATPase activity
CPR_2343	COG0280	phosphate acetyltransferase
CPR_2344	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CPR_2346	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CPR_2348	COG3409	Peptidoglycan-binding domain 1 protein
CPR_2348	COG3773	Cell wall hydrolase
CPR_2350	COG3118	belongs to the thioredoxin family
CPR_2351	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CPR_2352	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CPR_2353	COG3290	protein histidine kinase activity
CPR_2353	COG3829	transcription factor binding
CPR_2355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPR_2356	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CPR_2357	COG1393	Belongs to the ArsC family
CPR_2360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CPR_2361	COG0860	N-Acetylmuramoyl-L-alanine amidase
CPR_2362	COG1283	sodium-dependent phosphate transmembrane transporter activity
CPR_2363	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CPR_2366	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CPR_2369	COG0203	ribosomal protein L17
CPR_2370	COG0202	RNA polymerase activity
CPR_2372	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CPR_2373	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CPR_2375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CPR_2379	COG0201	protein transport
CPR_2380	COG0200	Binds to the 23S rRNA
CPR_2381	COG1841	ribosomal large subunit assembly
CPR_2382	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CPR_2383	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CPR_2384	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CPR_2385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CPR_2386	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CPR_2387	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CPR_2389	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CPR_2391	COG0255	Belongs to the universal ribosomal protein uL29 family
CPR_2392	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CPR_2393	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CPR_2394	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CPR_2395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CPR_2396	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CPR_2397	COG0089	rRNA binding
CPR_2400	COG0051	transcription antitermination factor activity, RNA binding
CPR_2402	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPR_2404	COG0049	tRNA binding
CPR_2405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CPR_2406	COG1358	cellular component organization or biogenesis
CPR_2407	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CPR_2409	COG0222	ribosome binding
CPR_2411	COG0081	regulation of translation
CPR_2412	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CPR_2413	COG0250	Participates in transcription elongation, termination and antitermination
CPR_2414	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CPR_2415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CPR_2416	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CPR_2420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CPR_2427	COG4956	integral membrane protein (PIN domain superfamily)
CPR_2430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CPR_2434	COG1012	belongs to the aldehyde dehydrogenase family
CPR_2437	COG0542	response to heat
CPR_2441	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CPR_2443	COG1774	PSP1 C-terminal conserved region
CPR_2444	COG0470	DNA polymerase III
CPR_2445	COG3870	Protein conserved in bacteria
CPR_2448	COG1982	Orn Lys Arg decarboxylase major
CPR_2453	COG1619	proteins homologs of microcin C7 resistance protein MccF
CPR_2462	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CPR_2464	COG1619	proteins homologs of microcin C7 resistance protein MccF
CPR_2468	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CPR_2469	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CPR_2470	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CPR_2472	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CPR_2474	COG0037	tRNA processing
CPR_2483	COG1098	S1 RNA binding domain
CPR_2487	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CPR_2489	COG3956	TIGRFAM MazG family protein
CPR_2490	COG2244	polysaccharide biosynthetic process
CPR_2491	COG2002	toxin-antitoxin pair type II binding
CPR_2493	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CPR_2495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CPR_2496	COG2205	protein histidine kinase activity
CPR_2497	COG0745	RESPONSE REGULATOR receiver
CPR_2501	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CPR_2505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CPR_2506	COG0006	proline dipeptidase activity
CPR_2514	COG0534	Mate efflux family protein
CPR_2516	COG1328	CTP reductase activity
CPR_2517	COG1470	cell adhesion involved in biofilm formation
CPR_2519	COG1695	Transcriptional regulator
CPR_2526	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CPR_2527	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CPR_2528	COG3583	domain protein
CPR_2528	COG3584	3D domain protein
CPR_2529	COG0084	hydrolase, TatD family'
CPR_2530	COG4399	Belongs to the UPF0754 family
CPR_2532	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CPR_2536	COG1757	Na H antiporter
CPR_2539	COG0006	proline dipeptidase activity
CPR_2541	COG0700	Nucleoside recognition
CPR_2542	COG2715	membrane protein required for spore maturation
CPR_2546	COG4232	protein-disulfide reductase activity
CPR_2553	COG0488	(ABC) transporter
CPR_2557	COG0446	pyridine nucleotide-disulphide oxidoreductase
CPR_2560	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CPR_2561	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CPR_2563	COG1242	4 iron, 4 sulfur cluster binding
CPR_2565	COG3949	Membrane
CPR_2567	COG1404	Belongs to the peptidase S8 family
CPR_2570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CPR_2573	COG0174	glutamine synthetase
CPR_2579	COG4624	Iron only hydrogenase large subunit, C-terminal domain
CPR_2579	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CPR_2581	COG1447	Phosphotransferase system cellobiose-specific component IIA
CPR_2584	COG1028	Short-chain dehydrogenase reductase Sdr
CPR_2585	COG0300	oxidoreductase activity
CPR_2590	COG0110	maltose O-acetyltransferase activity
CPR_2595	COG2824	Alkylphosphonate utilization operon protein PhnA
CPR_2600	COG1447	Phosphotransferase system cellobiose-specific component IIA
CPR_2601	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPR_2602	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CPR_2603	COG2723	6-phospho-beta-galactosidase activity
CPR_2605	COG1940	carbohydrate kinase activity
CPR_2613	COG0653	protein targeting
CPR_2615	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CPR_2620	COG1404	Belongs to the peptidase S8 family
CPR_2621	COG1196	nuclear chromosome segregation
CPR_2621	COG0741	lytic transglycosylase activity
CPR_2621	COG0739	heme binding
CPR_2635	COG2081	HI0933 family
CPR_2638	COG1773	rubredoxin
CPR_2638	COG1592	Rubrerythrin
CPR_2640	COG0494	nUDIX hydrolase
CPR_2642	COG1760	l-serine dehydratase
CPR_2643	COG1760	l-serine dehydratase
CPR_2644	COG2222	sugar isomerase
CPR_2645	COG0191	fructose-bisphosphate aldolase activity
CPR_2647	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CPR_2648	COG0305	Participates in initiation and elongation during chromosome replication
CPR_2649	COG0470	DNA polymerase III
CPR_2649	COG1067	ATP-dependent peptidase activity
CPR_2650	COG0359	binds to the 23S rRNA
CPR_2651	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CPR_2652	COG4241	membrane
CPR_2654	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CPR_2656	COG0360	Binds together with S18 to 16S ribosomal RNA
CPR_2658	COG0668	transmembrane transport
CPR_2661	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CPR_2665	COG1475	DNA binding
CPR_2666	COG1192	Involved in chromosome partitioning
CPR_2670	COG1847	R3H domain protein
CPR_2672	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CPR_2673	COG0594	ribonuclease P activity
CPR_2674	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CPR_A0010	COG1598	PFAM Uncharacterised protein family UPF0150
CPR_C0015	COG1802	Transcriptional regulator
CPR_C0015	COG4626	Terminase